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Peter Kwong

Research Profile

Chemicals & Drugs

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HIV-1

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Genes & Molecular Sequences

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TOP 3
Ivelin S Georgiev; Young Do Kwon; Han R Altae-Tran; Robert T Bailer; Gwo-Yu Chuang; Mark Connors; Nicole A Doria-Rose; Mark K Louder; Malcolm A Martin; John R Mascola; Krisha McKee; Stephen A Migueles; Stephanie Moquin; Lynn Morris; Martha Nason; Yoshiaki Nishimura; Sijy O'Dell; Gilad Ofek; Marie Pancera; Stephen D Schmidt; Lawrence Shapiro; Sanjay Srivatsan; Ryan P Staupe; Tongqing Zhou; Peter D Kwong
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Jiang Zhu; S Munir Alam; Julie Blinn; Dennis R Burton; Joshua Eudailey; Barton F Haynes; Wayne C Koff; Krissey E Lloyd; Mark K Louder; Gabriel Lu; John R Mascola; Krisha McKee; James C Mullikin; Gilad Ofek; Marie Pancera; Robert Parks; Lawrence Shapiro; Melissa Simek; Jeff Skinner; Yongping Yang; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
Florian Klein; Peter D Kwong; Hugo Mouquet; Pamela J Bjorkman; Ron Diskin; Brooks Zhongzheng Fu; Christian Gaebler; Ivelin S Georgiev; Priyanthi N P Gnanapragasam; Reha-Baris Incesu; Thiago Y Oliveira; Marie Pancera; Johannes F Scheid; Michael S Seaman; Tongqing Zhou; Michel C Nussenzweig
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

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All Publications

2013: Ivelin S Georgiev; Young Do Kwon; Han R Altae-Tran; Robert T Bailer; Gwo-Yu Chuang; Mark Connors; Nicole A Doria-Rose; Mark K Louder; Malcolm A Martin; John R Mascola; Krisha McKee; Stephen A Migueles; Stephanie Moquin; Lynn Morris; Martha Nason; Yoshiaki Nishimura; Sijy O'Dell; Gilad Ofek; Marie Pancera; Stephen D Schmidt; Lawrence Shapiro; Sanjay Srivatsan; Ryan P Staupe; Tongqing Zhou; Peter D Kwong
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Science (New York, N.Y.) 2013;340(6133):751-6.
2013: Jiang Zhu; S Munir Alam; Julie Blinn; Dennis R Burton; Joshua Eudailey; Barton F Haynes; Wayne C Koff; Krissey E Lloyd; Mark K Louder; Gabriel Lu; John R Mascola; Krisha McKee; James C Mullikin; Gilad Ofek; Marie Pancera; Robert Parks; Lawrence Shapiro; Melissa Simek; Jeff Skinner; Yongping Yang; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6470-5.
2013: Florian Klein; Peter D Kwong; Hugo Mouquet; Pamela J Bjorkman; Ron Diskin; Brooks Zhongzheng Fu; Christian Gaebler; Ivelin S Georgiev; Priyanthi N P Gnanapragasam; Reha-Baris Incesu; Thiago Y Oliveira; Marie Pancera; Johannes F Scheid; Michael S Seaman; Tongqing Zhou; Michel C Nussenzweig
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell 2013;153(1):126-38.
2013: M Gordon Joyce; Masaru Kanekiyo; Peter D Kwong; John R Mascola; Stephanie Moquin; Christian Biertümpfel; Jeffrey C Boyington; Wei Shi; Xueling Wu; Ling Xu; Yongping Yang; Zhi-Yong Yang; Baoshan Zhang; Anqi Zheng; Tongqing Zhou; Jiang Zhu; Gary Nabel
Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04.
Journal of virology 2013;87(4):2294-306.
2013: Marie Pancera; Jonathan Stuckey; Yongping Yang; Jiang Zhu; Dennis R Burton; Jason Gorman; Wayne C Koff; Mark K Louder; Gabriel Lu; John R Mascola; Jason S McLellan; Peter D Kwong
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.
PloS one 2013;8(2):e55701.
2012: Jinghe Huang; Hiromi Imamichi; Peter D Kwong; Leo Laub; Nancy S Longo; Mark K Louder; John R Mascola; Stephen A Migueles; Gilad Ofek; Shailendra K Sharma; Tao Wang; Richard Wyatt; Yongping Yang; Baoshan Zhang; S Munir Alam; Robert T Bailer; Bimal Chakrabarti; Nicole A Doria-Rose; Barton F Haynes; Mark Connors
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Nature 2012;491(7424):406-12.
2012: Rui Kong; Peter D Kwong; Johannes P M Langedijk; George K Lewis; Hui Li; James E Robinson; Sarah L Rowland-Jones; Frederic Bibollet-Ruche; Anita Changela; Julie M Decker; Ivelin Georgiev; Yongjun Guan; Beatrice H Hahn; Assan Jaye; George M Shaw
Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies.
Journal of virology 2012;86(22):12115-28.
2012: Peter D Kwong; John R Mascola
Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.
Immunity 2012;37(3):412-25.
2012: Gwo-Yu Chuang; Jeffrey C Boyington; M Gordon Joyce; Peter D Kwong; Gary Nabel; Jiang Zhu; Ivelin Georgiev
Computational prediction of N-linked glycosylation incorporating structural properties and patterns.
Bioinformatics (Oxford, England) 2012;28(17):2249-55.
2012: Andrés Finzi; Alon Herschhorn; Peter D Kwong; Beatriz Pacheco; Marie Pancera; Liping Wang; Shi-Hua Xiang; Xing Zeng; Anik Desormeaux; Joseph Sodroski
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.
Journal of virology 2012;86(17):8974-86.
2012: Nicole A Doria-Rose; Ivelin Georgiev; Jason Gorman; Barton F Haynes; Wayne C Koff; Peter D Kwong; Jason S McLellan; Sijy O'Dell; Marie Pancera; Ryan P Staupe; Mattia Bonsignori; Dennis R Burton; Gwo-Yu Chuang; John R Mascola
A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
Journal of virology 2012;86(15):8319-23.
2012: Judith M LaLonde; Navid Madani; John R Mascola; Amy M Princiotto; Arne Schön; Joel R Courter; Ernesto Freire; David M Jones; Toyoharu Kobayashi; Young Do Kwon; Peter D Kwong; Joseph Sodroski; Takahiro Soeta; Alexander W Sun; Xueling Wu; Amos B Smith
Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.
Journal of medicinal chemistry 2012;55(9):4382-96.
2012: Cajetan Dogo-Isonagie; Elena Gustchina; Peter D Kwong; Son Lam; Syed Shahzad-ul-Hussan; Yongping Yang; Priyamvada Acharya; G Marius Clore; Carole A Bewley
Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.
The Journal of biological chemistry 2012;287(18):15076-86.
2012: Young Do Kwon; Carole A Bewley; Asim K Debnath; Cajetan Dogo-Isonagie; Andrés Finzi; Lawrence K Lee; John R Mascola; Lucas R Moore; Stephen D Schmidt; Lawrence Shapiro; Joseph G Sodroski; Jonathan Stuckey; David A Vicic; Xueling Wu; Yongping Yang; Tongqing Zhou; Jiang Zhu; Peter D Kwong
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5663-8.
2012: Mallika Sastry; Carole A Bewley; Peter D Kwong
Mammalian expression of isotopically labeled proteins for NMR spectroscopy.
Advances in experimental medicine and biology 2012;992():197-211.
2012: Jiang Zhu; Dennis R Burton; Wayne C Koff; John R Mascola; James C Mullikin; Sijy O'Dell; Gilad Ofek; Marie Pancera; Lawrence Shapiro; Melissa Simek; Xueling Wu; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics.
Frontiers in microbiology 2012;3():315.
2012: Peter D Kwong; John R Mascola; Gary Nabel
The changing face of HIV vaccine research.
Journal of the International AIDS Society 2012;15(2):17407.
2012: Katharine J Bar; Mattia Bonsignori; Xi Chen; Julie M Decker; William Fischer; Vitaly V Ganusov; Feng Gao; Ivelin Georgiev; Beatrice H Hahn; Barton F Haynes; Peter T Hraber; Kwan-Ki Hwang; Shilpa S Iyer; Brandon F Keele; Bette T Korber; Peter D Kwong; Hui Li; Hua-Xin Liao; Jason S McLellan; David C Montefiori; Jeffrey W Pavlicek; Alan S Perelson; Sarah Sterrett; Chun-yen Tsao; Shuyi Wang; Yongping Yang; George M Shaw
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.
PLoS pathogens 2012;8(5):e1002721.
2011: Priyamvada Acharya; Carole A Bewley; Asim K Debnath; Cajetan Dogo-Isonagie; Leah L Frye; Jeremy R Greenwood; James A Hoxie; Judith M LaLonde; Son N Lam; George J Leslie; Mark K Louder; Timothy S Luongo; Loic MARTIN; John R Mascola; K Shawn Watts; Peter D Kwong
Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry.
ACS chemical biology 2011;6(10):1069-77.
2011: Gary Nabel; Peter D Kwong; John R Mascola
Progress in the rational design of an AIDS vaccine.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2759-65.
2011: Jason S McLellan; Yongping Yang; Barney S Graham; Peter D Kwong
Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
Journal of virology 2011;85(15):7788-96.
2011: Mallika Sastry; Ling Xu; Carole A Bewley; Ivelin S Georgiev; Gary Nabel; Peter D Kwong
Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.
Journal of biomolecular NMR 2011;50(3):197-207.
2011: Jason S McLellan; Bruno E Correia; Man Chen; Yongping Yang; Barney S Graham; William R Schief; Peter D Kwong
Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.
Journal of molecular biology 2011;409(5):853-66.
2011: Xueling Wu; Anita Changela; Sijy O'Dell; Stephen D Schmidt; Marie Pancera; Yongping Yang; Baoshan Zhang; Miroslaw K Gorny; Sanjay Phogat; James E Robinson; Leonidas Stamatatos; Susan Zolla-Pazner; Peter D Kwong; John R Mascola
Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies.
Journal of virology 2011;85(9):4578-85.
2011: Anita Changela; Xueling Wu; Yongping Yang; Baoshan Zhang; Jiang Zhu; Glenn A Nardone; Sijy O'Dell; Marie Pancera; Miroslaw K Gorny; Sanjay Phogat; James E Robinson; Leonidas Stamatatos; Susan Zolla-Pazner; John R Mascola; Peter D Kwong
Crystal structure of human antibody 2909 reveals conserved features of quaternary structure-specific antibodies that potently neutralize HIV-1.
Journal of virology 2011;85(6):2524-35.
2011: Javier Guenaga; Pia Dosenovic; Gilad Ofek; David Baker; William R Schief; Peter D Kwong; Gunilla B Karlsson Hedestam; Richard Wyatt
Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.
PloS one 2011;6(1):e16074.
2011: Judith M Lalonde; Mark A Elban; Joel R Courter; Akihiro Sugawara; Takahiro Soeta; Navid Madani; Amy M Princiotto; Young Do Kwon; Peter D Kwong; Arne Schön; Ernesto Freire; Joseph Sodroski; Amos B Smith
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.
Bioorganic & medicinal chemistry 2011;19(1):91-101.
2010: Jason S McLellan; Man Chen; Jung-San Chang; Yongping Yang; Albert Kim; Barney S Graham; Peter D Kwong
Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F.
Journal of virology 2010;84(23):12236-44.
2010: Gilad Ofek; F Javier Guenaga; William R Schief; Jeff Skinner; David Baker; Richard Wyatt; Peter D Kwong
Elicitation of structure-specific antibodies by epitope scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):17880-7.
2010: Leopold Kong; Neil C Sheppard; Guillaume B E Stewart-Jones; Cynthia L Robson; Hongying Chen; Xiaodong Xu; George Krashias; Camille Bonomelli; Christopher N Scanlan; Peter D Kwong; Simon A Jeffs; Ian M Jones; Quentin J Sattentau
Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity.
Journal of molecular biology 2010;403(1):131-47.
2010: Leopold Kong; Chih-Chin Huang; Stephen J Coales; Kathleen S Molnar; Jeff Skinner; Yoshitomo Hamuro; Peter D Kwong
Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange.
Journal of virology 2010;84(19):10311-21.
2010: Andrés Finzi; Beatriz Pacheco; Xin Zeng; Young Do Kwon; Peter D Kwong; Joseph Sodroski
Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells.
Journal of virological methods 2010;168(1-2):155-61.
2010: Xueling Wu; Zhi-Yong Yang; Yuxing Li; Carl-Magnus Hogerkorp; William R Schief; Michael S Seaman; Tongqing Zhou; Stephen D Schmidt; Lan Wu; Ling Xu; Nancy S Longo; Krisha McKee; Sijy O'Dell; Mark K Louder; Diane L Wycuff; Yu Feng; Martha Nason; Nicole Doria-Rose; Mark Connors; Peter D Kwong; Mario Roederer; Richard Wyatt; Gary Nabel; John R Mascola
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
Science (New York, N.Y.) 2010;329(5993):856-61.
2010: Tongqing Zhou; Ivelin Georgiev; Xueling Wu; Zhi-Yong Yang; Kaifan Dai; Andrés Finzi; Young Do Kwon; Johannes F Scheid; Wei Shi; Ling Xu; Yongping Yang; Jiang Zhu; Michel C Nussenzweig; Joseph Sodroski; Lawrence Shapiro; Gary Nabel; John R Mascola; Peter D Kwong
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Science (New York, N.Y.) 2010;329(5993):811-7.
2010: Marie Pancera; Jason S McLellan; Xueling Wu; Jiang Zhu; Anita Changela; Stephen D Schmidt; Yongping Yang; Tongqing Zhou; Sanjay Phogat; John R Mascola; Peter D Kwong
Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
Journal of virology 2010;84(16):8098-110.
2010: Shi-Hua Xiang; Andrés Finzi; Beatriz Pacheco; Kevin Alexander; Wen Yuan; Carlo D Rizzuto; Chih-Chin Huang; Peter D Kwong; Joseph Sodroski
A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer.
Journal of virology 2010;84(7):3147-61.
2010: Andrés Finzi; Shi-Hua Xiang; Beatriz Pacheco; Liping Wang; Jessica Haight; Aemro Kassa; Brenda Danek; Marie Pancera; Peter D Kwong; Joseph Sodroski
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.
Molecular cell 2010;37(5):656-67.
2010: Chantelle Ahlenstiel; Jonathan Abraham; Jeffrey C Boyington; Kwanyee Leung; Peter D Kwong; Gary Nabel
Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity.
Journal of virology 2010;84(6):2972-82.
2010: Jason S McLellan; Man Chen; Albert Kim; Yongping Yang; Barney S Graham; Peter D Kwong
Structural basis of respiratory syncytial virus neutralization by motavizumab.
Nature structural & molecular biology 2010;17(2):248-50.
2010: Marie Pancera; Shahzad Majeed; Yih-En Andrew Ban; Lei Chen; Chih-chin Huang; Leopold Kong; Young Do Kwon; Jonathan Stuckey; Tongqing Zhou; James E Robinson; William R Schief; Joseph Sodroski; Richard Wyatt; Peter D Kwong
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(3):1166-71.
2009: Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science (New York, N.Y.) 2009;326(5956):1123-7.
2009: Xueling Wu; Tongqing Zhou; Sijy O'Dell; Richard Wyatt; Peter D Kwong; John R Mascola
Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment.
Journal of virology 2009;83(21):10892-907.
2009: Peter D Kwong; John R Mascola; Gary Nabel
Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.
Cell host & microbe 2009;6(4):292-4.
2009: Aemro Kassa; Navid Madani; Arne Schön; Hillel Haim; Andrés Finzi; Shi-Hua Xiang; Liping Wang; Amy Princiotto; Marie Pancera; Joel Courter; Amos B Smith; Ernesto Freire; Peter D Kwong; Joseph Sodroski
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.
Journal of virology 2009;83(17):8364-78.
2009: Peter D Kwong; Ian A Wilson
HIV-1 and influenza antibodies: seeing antigens in new ways.
Nature immunology 2009;10(6):573-8.
2009: Barna Dey; Krisha Svehla; Ling Xu; Dianne Wycuff; Tongqing Zhou; Gerald Voss; Adhuna Phogat; Bimal K Chakrabarti; Yuxing Li; George Shaw; Peter D Kwong; Gary Nabel; John R Mascola; Richard Wyatt
Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site.
PLoS pathogens 2009;5(5):e1000445.
2009: Lan Wu; Tongqing Zhou; Zhi-Yong Yang; Krisha Svehla; Sijy O'Dell; Mark K Louder; Ling Xu; John R Mascola; Dennis R Burton; James A Hoxie; Robert W Doms; Peter D Kwong; Gary Nabel
Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
Journal of virology 2009;83(10):5077-86.
2009: Katie L Davis; Frederic Bibollet-Ruche; Hui Li; Julie M Decker; Olaf Kutsch; Lynn Morris; Aidy Salomon; Abraham Pinter; James A Hoxie; Beatrice H Hahn; Peter D Kwong; George M Shaw
Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma.
Journal of virology 2009;83(3):1240-59.
2008: Son N Lam; Priyamvada Acharya; Richard Wyatt; Peter D Kwong; Carole A Bewley
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.
Bioorganic & medicinal chemistry 2008;16(23):10113-20.
2008: Navid Madani; Arne Schön; Amy M Princiotto; Judith M Lalonde; Joel R Courter; Takahiro Soeta; Danny Ng; Liping Wang; Evan T Brower; Shi-Hua Xiang; Young Do Kwon; Chih-Chin Huang; Richard Wyatt; Peter D Kwong; Ernesto Freire; Amos B Smith; Joseph Sodroski
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.
Structure (London, England : 1993) 2008;16(11):1689-701.
2008: François Stricher; Chih-chin Huang; Anne Descours; Sophie Duquesnoy; Olivier Combes; Julie M Decker; Young Do Kwon; Paolo Lusso; George M Shaw; Claudio Vita; Peter D Kwong; Loic MARTIN
Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.
Journal of molecular biology 2008;382(2):510-24.
2007: Hui Xie; Danny Ng; Sergey N Savinov; Barna Dey; Peter D Kwong; Richard Wyatt; Amos B Smith; Wayne A Hendrickson
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.
Journal of medicinal chemistry 2007;50(20):4898-908.
2007: Chih-Chin Huang; Son N Lam; Priyamvada Acharya; Min Tang; Shi-Hua Xiang; Syed Shahzad-Ul Hussan; Robyn L Stanfield; James Robinson; Joseph Sodroski; Ian A Wilson; Richard Wyatt; Carole A Bewley; Peter D Kwong
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
Science (New York, N.Y.) 2007;317(5846):1930-4.
2007: George Lin; Andrea Bertolotti-Ciarlet; Beth Haggarty; Josephine Romano; Katrina M Nolan; George J Leslie; Andrea P O Jordan; Chih-chin Huang; Peter D Kwong; Robert W Doms; James A Hoxie
Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
Journal of virology 2007;81(18):9956-66.
2007: Barna Dey; Marie Pancera; Krisha Svehla; Yuuei Shu; Shi-Hua Xiang; Jeffrey Vainshtein; Yuxing Li; Joseph Sodroski; Peter D Kwong; John R Mascola; Richard Wyatt
Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.
Journal of virology 2007;81(11):5579-93.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2005: Chih-chin Huang; Min Tang; Mei-Yun Zhang; Shahzad Majeed; Elizabeth Montabana; Robyn L Stanfield; Dimiter S Dimitrov; Bette Korber; Joseph Sodroski; Ian A Wilson; Richard Wyatt; Peter D Kwong
Structure of a V3-containing HIV-1 gp120 core.
Science (New York, N.Y.) 2005;310(5750):1025-8.
2005: Tongqing Zhou; Dean H Hamer; Wayne A Hendrickson; Quentin J Sattentau; Peter D Kwong
Interfacial metal and antibody recognition.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14575-80.
2005: Marie Pancera; Jacob Lebowitz; Arne Schön; Ping Zhu; Ernesto Freire; Peter D Kwong; Kenneth H Roux; Joseph Sodroski; Richard Wyatt
Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis.
Journal of virology 2005;79(15):9954-69.
2005: Julie M Decker; Frederic Bibollet-Ruche; Xiping Wei; shuyi wang; David N Levy; Wenquan Wang; Eric Delaporte; Martine Peeters; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Michael S Saag; James A Hoxie; Beatrice H Hahn; Peter D Kwong; James E Robinson; George M Shaw
Antigenic conservation and immunogenicity of the HIV coreceptor binding site.
The Journal of experimental medicine 2005;201(9):1407-19.
2005: Chih-chin Huang; François Stricher; Loic MARTIN; Julie M Decker; Shahzad Majeed; Philippe Barthe; Wayne A Hendrickson; James Robinson; Christian Roumestand; Joseph Sodroski; Richard Wyatt; George M Shaw; Claudio Vita; Peter D Kwong
Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure (London, England : 1993) 2005;13(5):755-68.
2004: Gilad Ofek; Min Tang; Anna Sambor; Hermann Katinger; John R Mascola; Richard Wyatt; Peter D Kwong
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope.
Journal of virology 2004;78(19):10724-37.
2004: Chih-chin Huang; Miro Venturi; Shahzad Majeed; Michael J Moore; Sanjay Phogat; Mei-Yun Zhang; Dimiter S Dimitrov; Wayne A Hendrickson; James Robinson; Joseph Sodroski; Richard Wyatt; Hyeryun Choe; Michael Farzan; Peter D Kwong
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2706-11.
2004: Dennis R Burton; Ronald C Desrosiers; Robert W Doms; Wayne C Koff; Peter D Kwong; John P Moore; Gary Nabel; Joseph Sodroski; Ian A Wilson; Richard Wyatt
HIV vaccine design and the neutralizing antibody problem.
Nature immunology 2004;5(3):233-6.
2003: Shi-Hua Xiang; Liping Wang; Mariam Abreu; Chih-Chin Huang; Peter D Kwong; Eric Rosenberg; James E Robinson; Joseph Sodroski
Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains.
Virology 2003;315(1):124-34.
2003: Aran F Labrijn; Pascal Poignard; Aarti Raja; Michael B Zwick; Karla Delgado; Michael Franti; James M Binley; Veronique Vivona; Christoph Grundner; Chih-Chin Huang; Miro Venturi; Christos J Petropoulos; Terri Wrin; Dimiter S Dimitrov; James Robinson; Peter D Kwong; Richard Wyatt; Joseph Sodroski; Dennis R Burton
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Journal of virology 2003;77(19):10557-65.
2003: Shahzad Majeed; Gilad Ofek; Adam Belachew; Chih-chin Huang; Tongqing Zhou; Peter D Kwong
Enhancing protein crystallization through precipitant synergy.
Structure (London, England : 1993) 2003;11(9):1061-70.
2003: Markus Koch; Marie Pancera; Peter D Kwong; Peter Kolchinsky; Christoph Grundner; Liping Wang; Wayne A Hendrickson; Joseph Sodroski; Richard Wyatt
Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.
Virology 2003;313(2):387-400.
2003: Hyeryun Choe; Wenhui Li; Paulette L Wright; Natalya Vasilieva; Miro Venturi; Chih-Chin Huang; Christoph Grundner; Tatyana Dorfman; Michael B Zwick; Liping Wang; Eric S Rosenberg; Peter D Kwong; Dennis R Burton; James E Robinson; Joseph Sodroski; Michael Farzan
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.
Cell 2003;114(2):161-70.
2003: Xiping Wei; Julie M Decker; shuyi wang; Huxiong Hui; John C Kappes; Xiaoyun Wu; Jesus F Salazar-Gonzalez; Maria G Salazar; J. Michael Kilby; Michael S Saag; Natalia L Komarova; Martin A Nowak; Beatrice H Hahn; Peter D Kwong; George M Shaw
Antibody neutralization and escape by HIV-1.
Nature 2003;422(6929):307-12.
2003: Aarti Raja; Miro Venturi; Peter D Kwong; Joseph Sodroski
CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5.
Journal of virology 2003;77(1):713-8.
2002: Peter D Kwong; Michael Doyle; David J Casper; Claudia Cicala; Stephanie A Leavitt; Shahzad Majeed; Tavis D Steenbeke; Miro Venturi; Irwin Chaiken; Michael Fung; Hermann Katinger; Paul W I H Parren; James Robinson; Donald Van Ryk; Liping Wang; Dennis R Burton; Ernesto Freire; Richard Wyatt; Joseph Sodroski; Wayne A Hendrickson; James Arthos
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature 2002;420(6916):678-82.
2002: Shi-Hua Xiang; Peter D Kwong; Rishi Gupta; Carlo D Rizzuto; David J Casper; Richard Wyatt; Liping Wang; Wayne A Hendrickson; Michael Doyle; Joseph Sodroski
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Journal of virology 2002;76(19):9888-99.
2002: Xinzhen Yang; Juliette Lee; Erin M Mahony; Peter D Kwong; Richard Wyatt; Joseph Sodroski
Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin.
Journal of virology 2002;76(9):4634-42.
2000: Peter D Kwong; Richard Wyatt; Shahzad Majeed; James Robinson; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Structure (London, England : 1993) 2000;8(12):1329-39.
2000: David G Myszka; Raymond W Sweet; Preston Hensley; Michael Brigham-Burke; Peter D Kwong; Wayne A Hendrickson; Richard Wyatt; Joseph Sodroski; Michael Doyle
Energetics of the HIV gp120-CD4 binding reaction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9026-31.
2000: Xinzhen Yang; L Florin; Michael Farzan; Peter Kolchinsky; Peter D Kwong; Joseph Sodroski; Richard Wyatt
Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution.
Journal of virology 2000;74(10):4746-54.
2000: Peter D Kwong; Richard Wyatt; Quentin J Sattentau; Joseph Sodroski; Wayne A Hendrickson
Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus.
Journal of virology 2000;74(4):1961-72.
2000: Maxime Moulard; Hugues Lortat-Jacob; I Mondor; G Roca; Richard Wyatt; Joseph Sodroski; L Zhao; W Olson; Peter D Kwong; Quentin J Sattentau
Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120.
Journal of virology 2000;74(4):1948-60.
1999: Wei Zhang; Gabriela Canziani; Carmela G Plugariu; Richard Wyatt; Joseph Sodroski; R Sweet; Peter D Kwong; Wayne A Hendrickson; Irwin Chaiken
Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.
Biochemistry 1999;38(29):9405-16.
1999: Peter D Kwong; Richard Wyatt; E Desjardins; James Robinson; J S Culp; B D Hellmig; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).
The Journal of biological chemistry 1999;274(7):4115-23.
1998: Carlo D Rizzuto; Richard Wyatt; N Hernández-Ramos; Ying Sun; Peter D Kwong; Wayne A Hendrickson; Joseph Sodroski
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.
Science (New York, N.Y.) 1998;280(5371):1949-53.
1998: Richard Wyatt; Peter D Kwong; E Desjardins; Raymond W Sweet; James Robinson; Wayne A Hendrickson; Joseph Sodroski
The antigenic structure of the HIV gp120 envelope glycoprotein.
Nature 1998;393(6686):705-11.
1998: Peter D Kwong; Richard Wyatt; James Robinson; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
Nature 1998;393(6686):648-59.
1998: James M Binley; Richard Wyatt; E Desjardins; Peter D Kwong; Wayne A Hendrickson; John P Moore; Joseph Sodroski
Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.
AIDS research and human retroviruses 1998;14(3):191-8.
1997: H Wu; Peter D Kwong; Wayne A Hendrickson
Dimeric association and segmental variability in the structure of human CD4.
Nature 1997;387(6632):527-30.
1995: Peter D Kwong; N Q McDonald; P B Sigler; Wayne A Hendrickson
Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action.
Structure (London, England : 1993) 1995;3(10):1109-19.
1995: L Shapiro; Peter D Kwong; A M Fannon; David R Colman; Wayne A Hendrickson
Considerations on the folding topology and evolutionary origin of cadherin domains.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6793-7.
1995: L Shapiro; A M Fannon; Peter D Kwong; A Thompson; M S Lehmann; G Grübel; J F Legrand; J Als-Nielsen; David R Colman; Wayne A Hendrickson
Structural basis of cell-cell adhesion by cadherins.
Nature 1995;374(6520):327-37.
1993: N Q McDonald; Peter D Kwong
Does noggin head a new class of Kunitz domain?
Trends in biochemical sciences 1993;18(6):208-9.
1992: Wayne A Hendrickson; Peter D Kwong; Daniel J Leahy; S E Ryu; H Yamaguchi; S Fleury; Rafick-Pierre Sékaly
Structural aspects of CD4 and CD8 involvement in the cellular immune response.
Cold Spring Harbor symposia on quantitative biology 1992;57():549-56.
1990: S E Ryu; Peter D Kwong; Alemseged Truneh; T G Porter; J Arthos; M Rosenberg; X P Dai; Nguyen-Huu Xuong; Richard Axel; Raymond W Sweet
Crystal structure of an HIV-binding recombinant fragment of human CD4.
Nature 1990;348(6300):419-26.
1990: Peter D Kwong; S E Ryu; Wayne A Hendrickson; Richard Axel; R M Sweet; Gail Folena-Wasserman; P Hensley; Raymond W Sweet
Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6423-7.
1989: Peter D Kwong; Wayne A Hendrickson; P B Sigler
Beta-bungarotoxin. Preparation and characterization of crystals suitable for structural analysis.
The Journal of biological chemistry 1989;264(32):19349-53.