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Suzanne Kyle

Research Profile

Chemicals & Drugs

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DNA Damage

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Publications

TOP 3
A Peasland; E Rowling; J Sarkaria; Lan-Zhen Wang; G Beale; T Chen; W A Cliby; R J Edmondson; A Hopkins; Suzanne Kyle; Nicola J Curtin
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.
Yvette Drew; Evan A Mulligan; Wan-Tse Vong; Huw D Thomas; Samra Kahn; Suzanne Kyle; Asima Mukhopadhyay; Gerrit Los; Zdenek Hostomsky; E Ruth Plummer; Richard J Edmondson; Nicola J Curtin
Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.
Suzanne Kyle; Huw D Thomas; J Mitchell; Nicola J Curtin
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.

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All Publications

2011: A Peasland; E Rowling; J Sarkaria; Lan-Zhen Wang; G Beale; T Chen; W A Cliby; R J Edmondson; A Hopkins; Suzanne Kyle; Nicola J Curtin
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.
British journal of cancer 2011;105(3):372-81.
2011: Yvette Drew; Evan A Mulligan; Wan-Tse Vong; Huw D Thomas; Samra Kahn; Suzanne Kyle; Asima Mukhopadhyay; Gerrit Los; Zdenek Hostomsky; E Ruth Plummer; Richard J Edmondson; Nicola J Curtin
Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.
Journal of the National Cancer Institute 2011;103(4):334-46.
2008: Suzanne Kyle; Huw D Thomas; J Mitchell; Nicola J Curtin
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
The British journal of radiology 2008;81 Spec No 1():S6-11.
2007: Huw D Thomas; Christopher R Calabrese; Michael A Batey; Stacie Canan; Zdenek Hostomsky; Suzanne Kyle; Karen A Maegley; David R Newell; Donald J Skalitzky; Lan-Zhen Wang; Stephen E Webber; Nicola J Curtin
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Molecular cancer therapeutics 2007;6(3):945-56.
2005: Helen E Bryant; Niklas Schultz; Huw D Thomas; Kayan M Parker; Dan Flower; Elena Lopez; Suzanne Kyle; Mark Meuth; Nicola J Curtin; Thomas Helleday
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Nature 2005;434(7035):913-7.
2004: Jayashree G Tikhe; Stephen E Webber; Zdenek Hostomsky; Karen A Maegley; Anne Ekkers; Jianke Li; Xiao-Hong Yu; Robert Almassy; Robert A Kumpf; Theodore J Boritzki; Cathy Zhang; Christopher R Calabrese; Nicola J Curtin; Suzanne Kyle; Huw D Thomas; Lan-Zhen Wang; A Hilary Calvert; Bernard T Golding; Roger J Griffin; David R Newell
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
Journal of medicinal chemistry 2004;47(22):5467-81.
2004: Alex W White; Nicola J Curtin; Brian W Eastman; Bernard T Golding; Zdenek Hostomsky; Suzanne Kyle; Jianke Li; Karen A Maegley; Donald J Skalitzky; Stephen E Webber; Xiao-Hong Yu; Roger J Griffin
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(10):2433-7.
2004: Nicola J Curtin; Lan-Zhen Wang; Anthie Yiakouvaki; Suzanne Kyle; Christine A Arris; Stacie S Canan Koch; Stephen E Webber; Barbara W Durkacz; Hilary Calvert; Zdenek Hostomsky; David R Newell
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):881-9.
2004: Christopher R Calabrese; Robert Almassy; Stephanie Barton; Michael A Batey; A Hilary Calvert; Stacie S Canan Koch; Barbara W Durkacz; Zdenek Hostomsky; Robert A Kumpf; Suzanne Kyle; Jianke Li; Karen A Maegley; David R Newell; Elena Notarianni; Ian J Stratford; Donald J Skalitzky; Huw D Thomas; Lan-Zhen Wang; Stephen E Webber; Kaye J Williams; Nicola J Curtin
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.
Journal of the National Cancer Institute 2004;96(1):56-67.
2003: Christopher R Calabrese; Michael A Batey; Huw D Thomas; Barbara W Durkacz; Lan-Zhen Wang; Suzanne Kyle; Donald J Skalitzky; Janke Li; Catherine Zhang; Theodore J Boritzki; Karen A Maegley; A Hilary Calvert; Zdenek Hostomsky; David R Newell; Nicola J Curtin
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2711-8.
2002: Stacie S Canan Koch; Lars H Thoresen; Jayashree G Tikhe; Karen A Maegley; Robert Almassy; Jianke Li; Xiao-Hong Yu; Scott E Zook; Robert A Kumpf; Cathy Zhang; Theodore J Boritzki; Rena N Mansour; Kanyin E Zhang; Anne Ekker; Christopher R Calabrese; Nicola J Curtin; Suzanne Kyle; Huw D Thomas; Lan-Zhen Wang; A Hilary Calvert; Bernard T Golding; Roger J Griffin; David R Newell; Stephen E Webber; Zdenek Hostomsky
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
Journal of medicinal chemistry 2002;45(23):4961-74.
2000: C A Delaney; Lan-Zhen Wang; Suzanne Kyle; Alex W White; A Hilary Calvert; Nicola J Curtin; Barbara W Durkacz; Zdenek Hostomsky; David R Newell
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2860-7.
2000: S Boulton; Suzanne Kyle; Barbara W Durkacz
Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin.
European journal of cancer (Oxford, England : 1990) 2000;36(4):535-41.
1999: S Boulton; Suzanne Kyle; Barbara W Durkacz
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage.
Carcinogenesis 1999;20(2):199-203.
1997: S Boulton; Suzanne Kyle; Barbara W Durkacz
Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repair.
British journal of cancer 1997;76(7):845-51.
1996: S Boulton; Suzanne Kyle; L Yalçintepe; Barbara W Durkacz
Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells.
Carcinogenesis 1996;17(11):2285-90.