FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Markku Laakso

Research Profile

Disorders

Geographic Areas

Finland

Chemicals & Drugs

Genes & Molecular Sequences

Devices

Glucose Clamp Technique

Co-author Network

Publications

TOP 3
J Wang; J Paananen; Pasi Soininen; A Stančáková; Mika Ala-Korpela; A J Kangas; J Kuusisto; Markku Laakso
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men.
Mikko Hiltunen; Susanna Kemppainen; Vinoth K M Khandelwal; Henna Koivisto; Marine Krzisch; Markku Laakso; Petra Mäkinen; Pasi Miettinen; Hilkka Soininen; Tea Tiilikainen; Maija Tusa; Saila Vepsäläinen; Nagendra Yaluri; Annakaisa Haapasalo; Heikki Tanila
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.
Taina Koponen; Leena Alhonen; Marc Cerrada-Gimenez; Sami Heikkinen; Esa Hohtola; Jussi Paananen; Eija Pirinen; Sini Pirnes-Karhu; Maija Tusa; Anne Uimari; Antti Virkamäki; Susanna Vuohelainen; Markku Laakso
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Markku Laakso (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: J Wang; J Paananen; Pasi Soininen; A Stančáková; Mika Ala-Korpela; A J Kangas; J Kuusisto; Markku Laakso
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men.
Journal of internal medicine 2012;272(6):562-72.
2012: Mikko Hiltunen; Susanna Kemppainen; Vinoth K M Khandelwal; Henna Koivisto; Marine Krzisch; Markku Laakso; Petra Mäkinen; Pasi Miettinen; Hilkka Soininen; Tea Tiilikainen; Maija Tusa; Saila Vepsäläinen; Nagendra Yaluri; Annakaisa Haapasalo; Heikki Tanila
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.
Journal of cellular and molecular medicine 2012;16(6):1206-22.
2012: Taina Koponen; Leena Alhonen; Marc Cerrada-Gimenez; Sami Heikkinen; Esa Hohtola; Jussi Paananen; Eija Pirinen; Sini Pirnes-Karhu; Maija Tusa; Anne Uimari; Antti Virkamäki; Susanna Vuohelainen; Markku Laakso
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.
Amino acids 2012;42(2-3):427-40.
2012: Blake E Haas; Steve Horvath; Jaakko Kaprio; Johanna Kuusisto; Markku Laakso; Elina Nikkola; Carlos A Aguilar-Salinas; Rita M Cantor; Mete Civelek; Ivette Cruz-Bautista; Kirsi H Pietiläinen; Laura Riba; Aila Rissanen; Teresa Tusie-Luna; Daphna Weissglas-Volkov; Päivi Pajukanta
Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes.
BMC medical genomics 2012;5():61.
2012: Johan G Eriksson; Jill Gelow; Eero Kajantie; Markku Laakso; Virpi Lindi; Clive Osmond; Kent L Thornburg; Matti Uusitupa; David J P Barker
Long-term effects of placental growth on overweight and body composition.
International journal of pediatrics 2012;2012():324185.
2011: Henna Cederberg; Jari Jokelainen; Sirkka Keinänen-Kiukaanniemi; Vesa-Matti Koivisto; Ulla Rajala; Heljä-Marja Surcel; Markku Laakso
Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention.
European journal of endocrinology / European Federation of Endocrine Societies 2011;165(2):243-8.
2011: Teemu Vepsäläinen; Minna Soinio; Auni Juutilainen; Markku Laakso; Seppo Lehto; Jukka Marniemi; Tapani Rönnemaa
Physical activity, high-sensitivity C-reactive protein, and total and cardiovascular disease mortality in type 2 diabetes.
Diabetes care 2011;34(7):1492-6.
2011: Henna Cederberg; Pirjo Härkönen; Tiina Ikäheimo; Jari Jokelainen; Markku Laakso; Mauri Laakso; Ilona Mikkola; Sirkka Keinänen-Kiukaanniemi
Exercise during military training improves cardiovascular risk factors in young men.
Atherosclerosis 2011;216(2):489-95.
2011: Blake E Haas; Daphna Weissglas-Volkov; Carlos Aguilar Salinas; Elina Nikkola; Laurent Vergnes; Ivette Cruz-Bautista; Laura Riba; Alena Stancakova; Johanna Kuusisto; Pasi Soininen; Antti J Kangas; Mika Ala-Korpela; Teresa Tusie-Luna; Markku Laakso; Päivi Pajukanta
Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1201-7.
2011: Suvi E Heinonen; Ivana Kholová; Markku Laakso; Elina Loponen; Petri I Mäkinen; Mari Merentie; Fatima Bosch; Marja Hedman; Seppo Ylä-Herttuala
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice.
Cardiovascular diabetology 2011;10():59.
2011: Kari Kaunisto; Marja Ojaniemi; Anna-Kaisa Juuti; Hanna Huopio; Markku Laakso; Riitta Veijola
[From injections to pills--neonatally diagnosed diabetes of mother and baby].
Duodecim; lääketieteellinen aikakauskirja 2011;127(6):559-62.
2010: Tuomas Kilpeläinen; David E Laaksonen; Timo A Lakka; Christian Herder; W Koenig; Jaana Lindström; Johan G Eriksson; Matti Uusitupa; H Kolb; Markku Laakso; Jaakko Tuomilehto
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2010;118(10):757-9.
2010: T Vepsäläinen; Minna Soinio; Seppo Lehto; A Juutilainen; Markku Laakso; Tapani Rönnemaa
Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes.
Diabetologia 2010;53(9):1886-9.
2010: Jianjun Wang; Alena Stancáková; Johanna Kuusisto; Markku Laakso
Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men.
The Journal of clinical endocrinology and metabolism 2010;95(8):3858-62.
2010: Helena Gylling; Merja Hallikainen; Jussi Pihlajamäki; PM Simonen; Johanna Kuusisto; Markku Laakso; Tatu A Miettinen
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study.
Journal of lipid research 2010;51(8):2422-7.
2010: A K Juuti; Esa Läärä; Ulla Rajala; Markku Laakso; Pirkko L Härkönen; Sirkka Keinänen-Kiukaanniemi; Liisa Hiltunen
Prevalence and associated factors of restless legs in a 57-year-old urban population in northern Finland.
Acta neurologica Scandinavica 2010;122(1):63-9.
2010: Eija Ruotsalainen; Alena Stancáková; Ilkka Vauhkonen; Urpu Salmenniemi; Jussi Pihlajamäki; Kari Punnonen; Markku Laakso
Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Atherosclerosis 2010;210(2):536-41.
2010: Jianjun Wang; Katriina Sarnola; Sanna Ruotsalainen; Leena Moilanen; Päivi Lepistö; Markku Laakso; Johanna Kuusisto
The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns.
Atherosclerosis 2010;210(1):237-42.
2010: Auni Juutilainen; Seppo Lehto; Matti Suhonen; Tapani Rönnemaa; Markku Laakso
Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects: 18-year follow-up study.
Diabetes care 2010;33(3):583-5.
2010: Markku Laakso
Cardiovascular disease in type 2 diabetes from population to man to mechanisms: the Kelly West Award Lecture 2008.
Diabetes care 2010;33(2):442-9.
2010: Eija Pirinen; Helena Gylling; Paula Itkonen; Nagendra Yaluri; Sami Heikkinen; Marko Pietilä; Teemu Kuulasmaa; Maija Tusa; Marc Cerrada-Gimenez; Jussi Pihlajamäki; Leena Alhonen; Juhani Jänne; Tatu A Miettinen; Markku Laakso
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.
Amino acids 2010;38(2):549-60.
2010: Peter Weyrich; Harald Staiger; Alena Stančáková; Fausto Machicao; Jürgen Machann; Fritz Schick; Norbert Stefan; Johanna Kuusisto; Markku Laakso; Silke Schäfer; Andreas Fritsche; Hans-Ulrich Häring
The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies.
PloS one 2010;5(11):e13980.
2010: Saila Laakso; Pauliina Utriainen; Markku Laakso; Raimo Voutilainen; Jarmo Jääskeläinen
Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children.
Hormone research in pædiatrics 2010;74(5):365-71.
2009: Markku Laakso
Lipid disorders in type 2 diabetes.
Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición 2009;56 Suppl 4():43-5.
2009: Steven J R Meex; Daphna Weissglas-Volkov; Carla J H van der Kallen; Donna J Thuerauf; Marleen M J van Greevenbroek; Casper G Schalkwijk; Coen D A Stehouwer; Edith J M Feskens; Lonneke Heldens; Torik A Ayoubi; Marten H Hofker; Bradly G Wouters; Robert Francois Vlietinck; Janet S Sinsheimer; Marja-Riitta Taskinen; Johanna Kuusisto; Markku Laakso; Tjerk W A de Bruin; Päivi Pajukanta; Christopher C Glembotski
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1322-7.
2009: Alena Stancáková; Tiina Kuulasmaa; Jussi Paananen; Anne U Jackson; Lori L Bonnycastle; Francis S Collins; Michael Boehnke; Johanna Kuusisto; Markku Laakso
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
Diabetes 2009;58(9):2129-36.
2009: Saila Lappalainen; Raimo Voutilainen; Pauliina Utriainen; Markku Laakso; Jarmo Jääskeläinen
Genetic variation of FTO and TCF7L2 in premature adrenarche.
Metabolism: clinical and experimental 2009;58(9):1263-9.
2009: Hana Koutnikova; Markku Laakso; Lu Lu; Roy Combe; Jussi Paananen; Teemu Kuulasmaa; Johanna Kuusisto; Hans-Ulrich Häring; Torben Hansen; Oluf Pedersen; Ulf Smith; Markolf Hanefeld; Robert Williams; Johan Auwerx
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
PLoS genetics 2009;5(8):e1000591.
2009: Bente K Kilhovd; Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Peter A Torjesen; Kristian F Hanssen; Markku Laakso
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women.
Atherosclerosis 2009;205(2):590-4.
2009: Helena Gylling; Merja Hallikainen; Olli T Raitakari; Markku Laakso; Erkki Vartiainen; Pia Salo; Vesa Korpelainen; Jouko Sundvall; Tatu A Miettinen
Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation.
The British journal of nutrition 2009;101(11):1688-95.
2009: Alena Stancáková; Martin Javorsky; Tiina Kuulasmaa; Steven M Haffner; Johanna Kuusisto; Markku Laakso
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men.
Diabetes 2009;58(5):1212-21.
2009: Miikka-Juhani Honka; Markku Vänttinen; Patricia Iozzo; Kirsi A Virtanen; Riikka Lautamäki; Kirsti Hällsten; Ronald J H Borra; Teemu Takala; Antti Viljanen; Jukka Kemppainen; Jussi Pihlajamäki; Juhani Knuuti; Pirjo Nuutila; Markku Laakso
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2009;58(4):541-6.
2009: Tiina J Lappalainen; Anna-Maija Tolppanen; Marjukka Kolehmainen; Ursula S Schwab; Jaana Lindström; Jaakko Tuomilehto; Leena Pulkkinen; Johan G Eriksson; Markku Laakso; Helena Gylling; Matti Uusitupa
The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.
Obesity (Silver Spring, Md.) 2009;17(4):832-6.
2009: Helena Gylling; Merja Hallikainen; Radhakrishnan A Rajaratnam; PM Simonen; Jussi Pihlajamäki; Markku Laakso; Tatu A Miettinen
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.
Metabolism: clinical and experimental 2009;58(3):401-7.
2009: Markku Laakso
Not for the eyes only: PAX6 and glucose metabolism.
Diabetologia 2009;52(3):381-4.
2009: Sami Heikkinen; Carmen Argmann; Jerome N Feige; Hana Koutnikova; Marie-France Champy; Nassim Dali-Youcef; Eric E Schadt; Markku Laakso; Johan Auwerx
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.
Cell metabolism 2009;9(1):88-98.
2009: Titta Salopuro; Leena Pulkkinen; Jaana Lindström; Marjukka Kolehmainen; Anna-Maija Tolppanen; Johan G Eriksson; Timo T Valle; Sirkka Aunola; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Markku Laakso; Matti Uusitupa
Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
BMC medical genetics 2009;10():94.
2009: Tiina Ahonen; Juha Saltevo; Markku Laakso; Hannu Kautiainen; Esko Kumpusalo; Mauno Vanhala
Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure.
Mediators of inflammation 2009;2009():959281.
2009: Peter Weyrich; Harald Staiger; Alena Stancáková; Silke A Schäfer; Kerstin Kirchhoff; Susanne Ullrich; Felicia Ranta; Baptist Gallwitz; Norbert Stefan; Fausto Machicao; Johanna Kuusisto; Markku Laakso; Andreas Fritsche; Hans-Ulrich Häring
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
BMC medical genetics 2009;10():77.
2008: Paola Ungaro; Raffaele Teperino; Paola Mirra; Angela Cassese; Francesca Fiory; Giuseppe Perruolo; Claudia Miele; Markku Laakso; Pietro Formisano; Francesco Beguinot
Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.
The Journal of biological chemistry 2008;283(45):30970-9.
2008: Markku Laakso
Diabetes as a 'cardiovascular disease equivalent': implications for treatment.
Nature clinical practice. Cardiovascular medicine 2008;5(11):682-3.
2008: Juha R Koikkalainen; Margareta Antila; Jyrki M P Lötjönen; Tiina Heliö; Kirsi Lauerma; Sari M Kivistö; Petri Sipola; Maija A Kaartinen; Satu T J Kärkkäinen; Eeva Reissell; Johanna Kuusisto; Markku Laakso; Matej Oresic; Markku S Nieminen; Keijo Peuhkurinen
Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data.
Radiology 2008;249(1):88-96.
2008: George Bakris; Michael Böhm; Gilles Dagenais; Hans-Christoph Diener; Toshiro Fujita; Philip B Gorelick; Sverre Erik Kjeldsen; Markku Laakso; Giuseppe Mancia; Bertram Pitt; Arya Sharma; Peter Sleight; Koon Teo; Thomas Unger; Michael Weber; Bryan Williams; Faiez Zannad
Cardiovascular protection for all individuals at high risk: evidence-based best practice.
Clinical research in cardiology : official journal of the German Cardiac Society 2008;97(10):713-25.
2008: Beverley Balkau; Leila Mhamdi; Jean-Michel Oppert; John Nolan; Alain Golay; Francesca Porcellati; Markku Laakso; Ele Ferrannini
Physical activity and insulin sensitivity: the RISC study.
Diabetes 2008;57(10):2613-8.
2008: Jenny C Lee; Daphna Weissglas-Volkov; Mira Kyttälä; Zari Dastani; Rita M Cantor; Eric M Sobel; Christopher Plaisier; James C Engert; Marleen M J van Greevenbroek; John P Kane; Mary J Malloy; Clive R Pullinger; Adriana Huertas-Vazquez; Carlos Aguilar Salinas; Teresa Tusie-Luna; Tjerk W A de Bruin; Bradley E Aouizerat; Carla C J van der Kallen; Carlo M Croce; Rami I Aqeilan; Michel Marcil; Jorma S A Viikari; Terho Lehtimäki; Olli T Raitakari; Johanna Kuusisto; Markku Laakso; Marja-Riitta Taskinen; Jacques Genest; Päivi Pajukanta
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
American journal of human genetics 2008;83(2):180-92.
2008: Juha Saltevo; Markku Laakso; J Jokelainen; Sirkka Keinänen-Kiukaanniemi; Esko Kumpusalo; Mauno Vanhala
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study.
Diabetes/metabolism research and reviews 2008;24(5):378-83.
2008: Juha Saltevo; Mauno Vanhala; Hannu Kautiainen; Esko Kumpusalo; Markku Laakso
Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(6):747-50.
2008: T W Boesgaard; J Zilinskaite; Markku Vänttinen; Markku Laakso; Per-Anders Jansson; Ann Hammarstedt; Ulf Smith; Norbert Stefan; A Fritsche; H Häring; M Hribal; Giorgio Sesti; D P Zobel; Oluf Pedersen; Torben Hansen
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.
Diabetologia 2008;51(5):816-20.
2008: Alena Stancáková; Jussi Pihlajamäki; Johanna Kuusisto; Norbert Stefan; Andreas Fritsche; Hans Häring; Francesco Andreozzi; Elena Succurro; Giorgio Sesti; Trine Welløv Boesgaard; Torben Hansen; Oluf Pedersen; Per-Anders Jansson; Ann Hammarstedt; Ulf Smith; Markku Laakso
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
The Journal of clinical endocrinology and metabolism 2008;93(5):1924-30.
2008: Xiao-Qing Liu; Andrew D Paterson; Ning He; Peter St George-Hyslop; Virpi Rauta; Carola Gronhagen-Riska; Markku Laakso; Lise Thibaudin; François Berthoux; Daniel C Cattran; York Pei
IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.
Journal of the American Society of Nephrology : JASN 2008;19(5):1025-33.
2008: Tomi Laitinen; Tiina Lyyra-Laitinen; Hanna Huopio; Ilkka Vauhkonen; Toivo Halonen; Juha Hartikainen; Leo Niskanen; Markku Laakso
Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2008;13(2):97-105.
2008: Kati H Miettinen; Johan Lassus; Veli-Pekka Harjola; Krista Siirilä-Waris; John Melin; Kari R Punnonen; Markku S Nieminen; Markku Laakso; Keijo Peuhkurinen
Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure.
European journal of heart failure 2008;10(4):396-403.
2008: Jianjun Wang; Sanna Ruotsalainen; Leena Moilanen; Päivi Lepistö; Markku Laakso; Johanna Kuusisto
The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.
Stroke; a journal of cerebral circulation 2008;39(4):1078-83.
2008: Claus Thamer; Jürgen Machann; Norbert Stefan; Silke A Schäfer; Fausto Machicao; Harald Staiger; Markku Laakso; Michael Böttcher; Claus Claussen; Fritz Schick; Andreas Fritsche; Hans-Ulrich Haring
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study.
The Journal of clinical endocrinology and metabolism 2008;93(4):1497-500.
2008: Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Kalevi Pyörälä; Markku Laakso
Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects.
Diabetes care 2008;31(4):714-9.
2008: Tuomas Kilpeläinen; Timo A Lakka; David E Laaksonen; Ursula Griebler; Titta Salopuro; Agata Kubaszek; Boryana Todorova; Olli Laukkanen; Jaana Lindström; Johan G Eriksson; Helena Hämäläinen; Sirkka Aunola; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaako Tuomilehto; Markku Laakso; Matti Uusitupa
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.
Metabolism: clinical and experimental 2008;57(3):428-36.
2008: Markku Laakso; J Zilinskaite; T Hansen; T Welløv Boesgaard; Markku Vänttinen; A Stancáková; Per-Anders Jansson; F Pellmé; Jens J Holst; Tiina Kuulasmaa; M L Hribal; Giorgio Sesti; Norbert Stefan; A Fritsche; H Häring; Oluf Pedersen; Ulf Smith
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Diabetologia 2008;51(3):502-11.
2008: Eija Ruotsalainen; Ilkka Vauhkonen; Urpu Salmenniemi; Jussi Pihlajamäki; Kari Punnonen; Sakari Kainulainen; Sirpa Jalkanen; Marko Salmi; Markku Laakso
Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects.
Atherosclerosis 2008;197(1):271-7.
2008: Virpi Lindi; Ursula S Schwab; Anne Louheranta; Bengt Vessby; Kjeld Hermansen; Linda Tapsell; Gabriele Riccardi; Angela A Rivellese; Markku Laakso; M I J Uusitupa
The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(2):88-95.
2008: Björn Friedrich; Peter Weyrich; Alena Stancáková; Jianjung Wang; Johanna Kuusisto; Markku Laakso; Giorgio Sesti; Elena Succurro; Ulf Smith; Torben Hansen; Oluf Pedersen; Fausto Machicao; Silke Schäfer; Florian Lang; Teut Risler; Susanne Ullrich; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.
PloS one 2008;3(11):e3506.
2008: Tuomas Kilpeläinen; Timo A Lakka; David E Laaksonen; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Virpi Lindi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
SNPs in PPARG associate with type 2 diabetes and interact with physical activity.
Medicine and science in sports and exercise 2008;40(1):25-33.
2007: Jarno Rutanen; Jussi Pihlajamäki; Markku Vänttinen; Urpu Salmenniemi; Eija Ruotsalainen; Tiina Kuulasmaa; Sakari Kainulainen; Johanna Kuusisto; Markku Laakso
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.
Obesity (Silver Spring, Md.) 2007;15(12):2902-7.
2007: Juha Saltevo; Mauno Vanhala; Hannu Kautiainen; Markku Laakso
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(4):328-31.
2007: Jianjun Wang; Sanna Ruotsalainen; Leena Moilanen; Päivi Lepistö; Markku Laakso; Johanna Kuusisto
Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns.
Diabetes care 2007;30(12):3099-104.
2007: Suvi E Heinonen; Pia Leppänen; Ivana Kholová; Henri Lumivuori; Sanna-Kaisa Häkkinen; Fatima Bosch; Markku Laakso; Seppo Ylä-Herttuala
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia.
Circulation research 2007;101(10):1058-67.
2007: Tuomas Kilpeläinen; Timo A Lakka; David E Laaksonen; Olli Laukkanen; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Sirkka Aunola; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes.
Physiological genomics 2007;31(2):264-72.
2007: Johanna Kuusisto; Laura Andrulionyte; Markku Laakso
Atherosclerosis and cardiovascular risk reduction with PPAR agonists.
Current atherosclerosis reports 2007;9(4):274-80.
2007: Chaiyasit Sittiwet; Helena Gylling; Merja Hallikainen; Jussi Pihlajamäki; Leena Moilanen; David E Laaksonen; Leo Niskanen; Jyrki J Agren; Markku Laakso; Tatu A Miettinen
Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control.
Atherosclerosis 2007;194(2):465-72.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Bente K Kilhovd; Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Peter A Torjesen; Kristian F Hanssen; Markku Laakso
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study.
Diabetologia 2007;50(7):1409-17.
2007: Helena Gylling; Merja Hallikainen; Marjukka Kolehmainen; Leena Toppinen; Jussi Pihlajamäki; Hannu M Mykkänen; Jyrki J Agren; Rainer Rauramaa; Markku Laakso; Tatu A Miettinen
Cholesterol synthesis prevails over absorption in metabolic syndrome.
Translational research : the journal of laboratory and clinical medicine 2007;149(6):310-6.
2007: Jianjun Wang; Johanna Kuusisto; Markku Vänttinen; Tiina Kuulasmaa; Jaana Lindström; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.
Diabetologia 2007;50(6):1192-200.
2007: Helena Tuunanen; Johanna Kuusisto; Jyri O Toikka; Pertti Jääskeläinen; Päivi Marjamäki; Keijo Peuhkurinen; Tapio Viljanen; Petri Sipola; Kira Q Stolen; Jarna C Hannukainen; Pirjo Nuutila; Markku Laakso; Juhani Knuuti
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3):354-65.
2007: Laura Andrulionyte; Tiina Kuulasmaa; Jean-Louis Chiasson; Markku Laakso
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2007;56(4):1181-6.
2007: Jianjun Wang; Sanna Ruotsalainen; Leena Moilanen; Päivi Lepistö; Markku Laakso; Johanna Kuusisto
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.
European heart journal 2007;28(7):857-64.
2007: Minna Soinio; Jukka Marniemi; Markku Laakso; Kalevi Pyörälä; Seppo Lehto; Tapani Rönnemaa
Serum zinc level and coronary heart disease events in patients with type 2 diabetes.
Diabetes care 2007;30(3):523-8.
2007: Jarno Rutanen; Jussi Pihlajamäki; Markku Vänttinen; Urpu Salmenniemi; Eija Ruotsalainen; Tiina Kuulasmaa; Sakari Kainulainen; Markku Laakso
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism 2007;92(3):1112-7.
2007: Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Kalevi Pyörälä; Markku Laakso
Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women.
Diabetes care 2007;30(2):292-9.
2007: Juha Saltevo; Mauno Vanhala; Hannu Kautiainen; Esko Kumpusalo; Markku Laakso
Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome.
Mediators of inflammation 2007;2007():93573.
2007: Markku Laakso; Matti Uusitupa
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(12):1439-47.
2007: Markku Laakso; Leif Groop
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(12):1427-9.
2006: Eija Ruotsalainen; Urpu Salmenniemi; Ilkka Vauhkonen; Jussi Pihlajamäki; Kari Punnonen; Sakari Kainulainen; Markku Laakso
Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.
Diabetes care 2006;29(12):2714-20.
2006: Hannele Karinen; Päivi Kärkkäinen; Jussi Pihlajamäki; Esko Janatuinen; Markku Heikkinen; Risto Julkunen; Veli-Matti Kosma; Anita Naukkarinen; Markku Laakso
HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease.
Scandinavian journal of gastroenterology 2006;41(11):1299-304.
2006: Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Markku Laakso; Sirkka Keinänen-Kiukaanniemi
The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.
Endocrine 2006;30(2):185-90.
2006: Kirsi Niiranen; Tuomo A Keinänen; Eija Pirinen; Sami Heikkinen; Maija Tusa; Szabolcs Fatrai; Suvikki Suppola; Marko Pietilä; Anne Uimari; Markku Laakso; Leena Alhonen; Juhani Jänne
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Ilze Kokina; Sanna Uotila; Tiia Ahtialansaari; Teemu Laitinen; Juhana Hakumaki; Markku Laakso; Karl-Heinz Herzig; Seppo Ylä-Herttuala
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2159-61.
2006: Matti Vanhanen; Keijo Koivisto; Leena Moilanen; Eeva-Liisa Helkala; Tuomo Hänninen; Hilkka Soininen; Kari Kervinen; Y Antero Kesäniemi; Markku Laakso; Johanna Kuusisto
Association of metabolic syndrome with Alzheimer disease: a population-based study.
Neurology 2006;67(5):843-7.
2006: Petri Sipola; Keijo Peuhkurinen; Kirsi Lauerma; Minna Husso; Pertti Jääskeläinen; Markku Laakso; Hannu J Aronen; J Risteli; Johanna Kuusisto
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: magnetic resonance imaging study.
Heart (British Cardiac Society) 2006;92(9):1321-2.
2006: Timo Saarela; Mikko Hiltunen; Seppo Helisalmi; Seppo Heinonen; Markku Laakso
Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia.
European journal of obstetrics, gynecology, and reproductive biology 2006;128(1-2):175-9.
2006: Laura Andrulionyte; Olli Laukkanen; Jean-Louis Chiasson; Markku Laakso
Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.
Journal of molecular medicine (Berlin, Germany) 2006;84(8):701-8.
2006: Niina Siitonen; Leena Pulkkinen; Ursula Griebler; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Markku Laakso; Matti Uusitupa
Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.
Diabetologia 2006;49(8):1795-805.
2006: Paula Peltola; Jussi Pihlajamäki; Hana Koutnikova; Eija Ruotsalainen; Urpu Salmenniemi; Ilkka Vauhkonen; Sakari Kainulainen; Helena Gylling; Tatu A Miettinen; Johan Auwerx; Markku Laakso
Visceral obesity is associated with high levels of serum squalene.
Obesity (Silver Spring, Md.) 2006;14(7):1155-63.
2006: Laura Andrulionyte; Paula Peltola; Jean-Louis Chiasson; Markku Laakso
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2006;55(7):2148-52.
2006: Jussi Pihlajamäki; Urpu Salmenniemi; Markku Vänttinen; Eija Ruotsalainen; Johanna Kuusisto; Ilkka Vauhkonen; Sakari Kainulainen; Maggie C Y Ng; N J Cox; G I Bell; Markku Laakso
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.
Diabetologia 2006;49(7):1560-6.
2006: Ursula Griebler; Virpi Lindi; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Markku Laakso; Leena Pulkkinen; Matti Uusitupa
Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(6):685-9.
2006: Satu Kärkkäinen; Eeva Reissell; Tiina Heliö; Maija Kaartinen; Petri Tuomainen; Lauri Toivonen; Johanna Kuusisto; M Kupari; Markku S Nieminen; Markku Laakso; Keijo Peuhkurinen
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy.
Heart (British Cardiac Society) 2006;92(4):524-6.
2006: Tuija Poutanen; Tero Tikanoja; Pertti Jääskeläinen; Eero Jokinen; Annuli Silvast; Markku Laakso; Johanna Kuusisto
Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes.
American heart journal 2006;151(3):725.e1-725.e9.
2006: Hannele Karinen; Päivi Kärkkäinen; Jussi Pihlajamäki; Esko Janatuinen; Markku Heikkinen; Risto Julkunen; Veli-Matti Kosma; Anita Naukkarinen; Markku Laakso
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.
Scandinavian journal of gastroenterology 2006;41(2):191-9.
2006: Minna Soinio; Jukka Marniemi; Markku Laakso; Seppo Lehto; Tapani Rönnemaa
High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study.
Diabetes care 2006;29(2):329-33.
2006: Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Sirkka Keinänen-Kiukaanniemi; Markku Laakso
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.
Molecular genetics and metabolism 2006;87(2):147-51.
2006: Markku Laakso
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(13):1563-4.
2006: Anne Maria Koivisto; Seppo Helisalmi; Jussi Pihlajamaki; Mikko Hiltunen; Keijo Koivisto; Leena Moilanen; Johanna Kuusisto; Eeva-Liisa Helkala; Tuomo Hanninen; Kari Kervinen; Y Antero Kesaniemi; Markku Laakso; Hilkka Soininen
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.
Dementia and geriatric cognitive disorders 2006;22(5-6):449-53.
2006: Timo Saarela; Mikko Hiltunen; Seppo Helisalmi; Seppo Heinonen; Markku Laakso
Adiponectin gene haplotype is associated with preeclampsia.
Genetic testing 2006;10(1):35-9.
2006: Anne Lumiaho; Markku Laakso
[Autosomal dominant polycystic kidney disease].
Duodecim; lääketieteellinen aikakauskirja 2006;122(2):200-7.
2006: Markku Laakso; Petri T Kovanen
Metabolic syndrome: to be or not to be?
Annals of medicine 2006;38(1):32-3.
2006: Timo Otonkoski; Kirsti Näntö-Salonen; Marko Seppänen; Riitta Veijola; Hanna Huopio; Khalid Hussain; Päivi Tapanainen; Olli Eskola; Riitta Parkkola; Klas Ekström; Yves Guiot; Jacques Rahier; Markku Laakso; Risto J Rintala; Pirjo Nuutila; Heikki Minn
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.
Diabetes 2006;55(1):13-8.
2006: Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Kalevi Pyörälä; Markku Laakso
Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women.
Diabetologia 2006;49(1):56-65.
2006: Timo Saarela; Mikko Hiltunen; Seppo Helisalmi; Seppo Heinonen; Markku Laakso
Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia.
Gynecologic and obstetric investigation 2006;61(3):124-7.
2006: José L González-Sánchez; María J Martínez-Calatrava; María T Martínez Larrad; Carina Zabena; Cristina Fernández Pérez; Markku Laakso; Manuel Serrano-Ríos
Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population.
Clinical chemistry 2006;52(1):97-103.
2005: Jukka S Luoma; Anu Kareinen; Outi Närvänen; Laura Viitanen; Markku Laakso; Seppo Ylä-Herttuala
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
Free radical biology & medicine 2005;39(12):1660-5.
2005: Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Kalevi Pyörälä; Markku Laakso
Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects.
Diabetes care 2005;28(12):2901-7.
2005: Markku Vänttinen; Pirjo Nuutila; Tiina Kuulasmaa; Jussi Pihlajamäki; Kirsti Hällsten; Kirsi A Virtanen; Riikka Lautamäki; Pauliina Peltoniemi; Teemu Takala; Antti Viljanen; Juhani Knuuti; Markku Laakso
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake.
Diabetes 2005;54(12):3587-91.
2005: Urpu Salmenniemi; Eija Ruotsalainen; Markku Vänttinen; Ilkka Vauhkonen; Jussi Pihlajamäki; Sakari Kainulainen; Kari Punnonen; Markku Laakso
High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients.
International journal of obesity (2005) 2005;29(12):1464-70.
2005: Titta Salopuro; Leena Pulkkinen; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Markku Laakso; Matti Uusitupa
Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study.
International journal of obesity (2005) 2005;29(10):1245-51.
2005: Petri Sipola; Kirsi Lauerma; Pertti Jääskeläinen; Markku Laakso; Keijo Peuhkurinen; Hannu Manninen; Hannu J Aronen; Johanna Kuusisto
Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene.
Radiology 2005;236(3):815-24.
2005: Anu Pätäri; P Karhapää; H Taipale; Urpu Salmenniemi; Eija Ruotsalainen; Paula Vanninen; Harry Holthöfer; Markku Laakso
A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients.
Diabetologia 2005;48(9):1844-50.
2005: Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Sirkka Keinänen-Kiukaanniemi; Markku Laakso
Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.
Endocrine 2005;27(3):307-9.
2005: Ilkka Vauhkonen; Leo Niskanen; Mikael Knip; Leena Moilanen Mykkänen; Steven M Haffner; Matti Uusitupa; Markku Laakso
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):265-73.
2005: Paula Peltola; Anne Lumiaho; Raija Miettinen; Jussi Pihlajamäki; Richard Sandford; Markku Laakso
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns.
Journal of molecular medicine (Berlin, Germany) 2005;83(8):638-46.
2005: Anne Maria Koivisto; Seppo Helisalmi; Jussi Pihlajamäki; Leena Moilanen; Johanna Kuusisto; Markku Laakso; Mikko Hiltunen; Koivisto Keijo; Tuomo Hänninen; Eeva-Liisa Helkala; Kari Kervinen; Y Antero Kesäniemi; Hilkka Soininen
Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Journal of neurogenetics 2005;19(3-4):155-61.
2005: Olli Laukkanen; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Diabetes 2005;54(7):2256-60.
2005: Jussi Pihlajamäki; M Kinnunen; Eija Ruotsalainen; Urpu Salmenniemi; Ilkka Vauhkonen; Tiina Kuulasmaa; Sakari Kainulainen; Markku Laakso
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.
Diabetologia 2005;48(7):1331-4.
2005: Urpu Salmenniemi; Jelena Zacharova; Eija Ruotsalainen; Ilkka Vauhkonen; Jussi Pihlajamäki; Sakari Kainulainen; Kari Punnonen; Markku Laakso
Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2005;90(7):4216-23.
2005: Markku Vänttinen; Pirjo Nuutila; Jussi Pihlajamäki; Kirsti Hällsten; Kirsi A Virtanen; Riikka Lautamäki; Pauliina Peltoniemi; Jukka Kemppainen; Teemu Takala; Antti Viljanen; Juhani Knuuti; Markku Laakso
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study.
The Journal of clinical endocrinology and metabolism 2005;90(7):4249-54.
2005: Timo Saarela; Mikko Hiltunen; Seppo Helisalmi; Seppo Heinonen; Markku Laakso
Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia.
Molecular human reproduction 2005;11(6):437-40.
2005: José L González-Sánchez; Carina Zabena; María T Martínez Larrad; Cristina Fernández Pérez; Milagros Pérez-Barba; Markku Laakso; Manuel Serrano-Ríos
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance.
Obesity research 2005;13(5):807-12.
2005: Markku Laakso
Prevention of type 2 diabetes.
Current molecular medicine 2005;5(3):365-74.
2005: Firoozeh Mousavinasab; Tuula Tähtinen; Jari Jokelainen; Pentti Koskela; Mauno Vanhala; Jorma Oikarinen; Sirkka Keinänen-Kiukaanniemi; Markku Laakso
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
Molecular genetics and metabolism 2005;84(4):344-8.
2005: Bente K Kilhovd; Auni Juutilainen; Seppo Lehto; Tapani Rönnemaa; Peter A Torjesen; Kåre I Birkeland; Tore J Berg; Kristian F Hanssen; Markku Laakso
High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):815-20.
2005: Jelena Zacharova; Jean-Louis Chiasson; Markku Laakso
Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance.
Obesity research 2005;13(3):501-6.
2005: Jelena Zacharova; Jean-Louis Chiasson; Markku Laakso
The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2005;54(3):893-9.
2005: Jelena Zacharova; B R Todorova; Jean-Louis Chiasson; Markku Laakso
The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Journal of internal medicine 2005;257(2):185-93.
2005: Markku Laakso
[New criteria and care for metabolic syndrome].
Duodecim; lääketieteellinen aikakauskirja 2005;121(14):1521-30.
2005: Hanna Huopio; Markku Laakso; Timo Otonkoski
[Congenital hyperinsulinism].
Duodecim; lääketieteellinen aikakauskirja 2005;121(11):1166-75.
2005: Ulla Rajala; Markku Laakso; Markku Päivänsalo; Ilkka Suramo; Sirkka Keinänen-Kiukaanniemi
Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance.
Journal of human hypertension 2005;19(1):85-91.
2004: Urpu Salmenniemi; Eija Ruotsalainen; Jussi Pihlajamäki; Ilkka Vauhkonen; Sakari Kainulainen; Kari Punnonen; Esko Vanninen; Markku Laakso
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome.
Circulation 2004;110(25):3842-8.
2004: L Andrulionytè; Jelena Zacharova; Jean-Louis Chiasson; Markku Laakso
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
Diabetologia 2004;47(12):2176-84.
2004: Olli Laukkanen; Jussi Pihlajamäki; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.
The Journal of clinical endocrinology and metabolism 2004;89(12):6286-90.
2004: Katariina Sivenius; Leo Niskanen; Raija Voutilainen-Kaunisto; Markku Laakso; Matti Uusitupa
Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1325-33.
2004: Auni Juutilainen; Saara Kortelainen; Seppo Lehto; Tapani Rönnemaa; Kalevi Pyörälä; Markku Laakso
Gender difference in the impact of type 2 diabetes on coronary heart disease risk.
Diabetes care 2004;27(12):2898-904.
2004: Satu Kärkkäinen; Tiina Heliö; Pertti Jääskeläinen; Raija Miettinen; Petri Tuomainen; Kari Ylitalo; Maija Kaartinen; Eeva Reissell; Lauri Toivonen; Markku S Nieminen; Johanna Kuusisto; Markku Laakso; Keijo Peuhkurinen
Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy.
European journal of heart failure 2004;6(7):861-8.
2004: John D Rioux; Hannele Karinen; Kerry Kocher; Sheila Guschwan McMahon; Päivi Kärkkäinen; Esko Janatuinen; Markku Heikkinen; Risto Julkunen; Jussi Pihlajamäki; Anita Naukkarinen; Veli-Matti Kosma; Mark J Daly; Eric S Lander; Markku Laakso
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
American journal of medical genetics. Part A 2004;130A(4):345-50.
2004: Titta Salopuro; J Lindström; J G Eriksson; T T Valle; H Hämäläinen; Pirjo Ilanne-Parikka; S Keinänen-Kiukaanniemi; J Tuomilehto; Markku Laakso; Matti Uusitupa
Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study.
Clinical genetics 2004;66(4):365-7.
2004: Theodora Temelkova-Kurktschiev; Markolf Hanefeld; Giulia Chinetti; Christophe Zawadzki; Stéphan Haulon; Agata Kubaszek; Carsta Koehler; Wolfgang Leonhardt; Bart Staels; Markku Laakso
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
The Journal of clinical endocrinology and metabolism 2004;89(9):4238-42.
2004: Helena Gylling; Merja Hallikainen; Jussi Pihlajamäki; Jyrki J Agren; Markku Laakso; Radhakrishnan A Rajaratnam; Rainer Rauramaa; Tatu A Miettinen
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity.
Journal of lipid research 2004;45(9):1660-5.
2004: Niina Siitonen; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Markku Laakso; Matti Uusitupa
Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.
Diabetologia 2004;47(8):1416-24.
2004: Katariina Sivenius; Jussi Pihlajamäki; Juhani Partanen; Leo Niskanen; Markku Laakso; Matti Uusitupa
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes.
Diabetes care 2004;27(8):2021-6.
2004: Antonio L Cuesta-Muñoz; Hanna Huopio; Timo Otonkoski; Juan M Gomez-Zumaquero; Kirsti Näntö-Salonen; Jacques Rahier; Soledad López-Enriquez; Maria A García-Gimeno; Pascual Sanz; Federico C Soriguer; Markku Laakso
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Diabetes 2004;53(8):2164-8.
2004: Jarno Rutanen; Jussi Pihlajamäki; Pauli Karhapää; Ilkka Vauhkonen; Johanna Kuusisto; Leena Moilanen Mykkänen; Markku Laakso
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.
Obesity research 2004;12(7):1060-6.
2004: Satu Kärkkäinen; Tiina Heliö; Raija Miettinen; Petri Tuomainen; Paula Peltola; Juha Rummukainen; Kari Ylitalo; Maija Kaartinen; Johanna Kuusisto; Lauri Toivonen; Markku S Nieminen; Markku Laakso; Keijo Peuhkurinen
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy.
European heart journal 2004;25(10):885-93.
2004: Olli Laukkanen; Jussi Pihlajamäki; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study.
Diabetologia 2004;47(5):871-7.
2004: Agata Kubaszek; Anu Markkanen; Johan G Eriksson; Forsen Tom; Clive Osmond; David J P Barker; Markku Laakso
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth.
The Journal of clinical endocrinology and metabolism 2004;89(5):2044-7.
2004: Boryana Todorova; Agata Kubaszek; Jussi Pihlajamäki; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study.
The Journal of clinical endocrinology and metabolism 2004;89(5):2019-23.
2004: Markku Laakso
Gene variants, insulin resistance, and dyslipidaemia.
Current opinion in lipidology 2004;15(2):115-20.
2004: Jussi Pihlajamäki; Helena Gylling; Tatu A Miettinen; Markku Laakso
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.
Journal of lipid research 2004;45(3):507-12.
2004: Jussi Pihlajamäki; Mauno Vanhala; Pasi Vanhala; Markku Laakso
The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood.
Obesity research 2004;12(2):187-90.
2004: Eija Pirinen; Sami Heikkinen; Mari Malkki; Samir S Deeb; Juhani Jänne; Markku Laakso
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.
Biochimica et biophysica acta 2004;1676(2):149-54.
2004: Minna Soinio; Jukka Marniemi; Markku Laakso; Seppo Lehto; Tapani Rönnemaa
Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus.
Annals of internal medicine 2004;140(2):94-100.
2004: Pertti Jääskeläinen; Raija Miettinen; Päivi Kärkkäinen; Lauri Toivonen; Markku Laakso; Johanna Kuusisto
Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes.
Annals of medicine 2004;36(1):23-32.
2004: Antti Hedman; Juha Hartikainen; Esko Vanninen; Tomi Laitinen; Pertti Jääskeläinen; Markku Laakso; Keijo Peuhkurinen; Johanna Kuusisto
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.
Journal of molecular and cellular cardiology 2004;36(1):91-9.
2003: Satu Kärkkäinen; Raija Miettinen; Petri Tuomainen; Päivi Kärkkäinen; Tiina Heliö; Eeva Reissell; Maija Kaartinen; Lauri Toivonen; Markku S Nieminen; Johanna Kuusisto; Markku Laakso; Keijo Peuhkurinen
A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) 2003;81(12):795-800.
2003: Ulla Rajala; Markku Päivänsalo; Markku Laakso; Outi Pelkonen; Ilkka Suramo; Sirkka Keinänen-Kiukaanniemi
Associations of blood pressure with carotid intima-media thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance.
Journal of human hypertension 2003;17(10):705-11.
2003: Tomi Laitinen; Hanna Huopio; Ilkka Vauhkonen; Cyril Camaro; Juha Hartikainen; Markku Laakso; Leo Niskanen
Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects.
Clinical science (London, England : 1979) 2003;105(3):315-22.
2003: Katariina Sivenius; Leo Niskanen; Markku Laakso; Matti Uusitupa
A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity.
Obesity research 2003;11(8):962-70.
2003: Johan G Eriksson; Clive Osmond; Virpi Lindi; Matti Uusitupa; Forsen Tom; Markku Laakso; David Barker
Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes.
Diabetes care 2003;26(8):2476-7.
2003: Jussi Pihlajamäki; Mari Ylinen; Pauli Karhapää; Ilkka Vauhkonen; Markku Laakso
The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.
Obesity research 2003;11(7):912-7.
2003: Agata Kubaszek; Jussi Pihlajamäki; Vladislav Komarovski; Virpi Lindi; Jaana Lindström; Johan Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Diabetes 2003;52(7):1872-6.
2003: Marja Hedman; Juha Hartikainen; Mikko Syvänne; Joachim Stjernvall; Antti Hedman; Antti Kivelä; Esko Vanninen; Hanna Mussalo; Esa Kauppila; Sakari Simula; Outi Närvänen; Arto Rantala; Keijo Peuhkurinen; Markku S Nieminen; Markku Laakso; Seppo Ylä-Herttuala
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
Circulation 2003;107(21):2677-83.
2003: Anne Lumiaho; Jussi Pihlajamäki; Juha Hartikainen; Risto Ikäheimo; Raija Miettinen; Lea Niemitukia; Erkki Lampainen; Markku Laakso
Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;41(6):1219-24.
2003: Virpi Lindi; Ursula S Schwab; Anne Louheranta; Markku Laakso; Bengt Vessby; Kjeld Hermansen; Len Storlien; Gabriele Riccardi; Angela A Rivellese
Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation.
Molecular genetics and metabolism 2003;79(1):52-60.
2003: Jussi Pihlajamäki; Pauli Karhapää; Ilkka Vauhkonen; Päivi Kekäläinen; Anu Kareinen; Laura Viitanen; Ullamari Pesonen; Jaana Kallio; Matti Uusitupa; Markku Laakso
The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism.
Metabolism: clinical and experimental 2003;52(5):643-6.
2003: José L González-Sánchez; María T Martínez Larrad; Cristina Fernández Pérez; Agata Kubaszek; Markku Laakso; Manuel Serrano-Ríos
K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.
Obesity research 2003;11(5):603-5.
2003: Marjukka Kolehmainen; M I J Uusitupa; Esko Alhava; Markku Laakso; Hubert Vidal
Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects.
The Journal of clinical endocrinology and metabolism 2003;88(4):1717-22.
2003: Petri Sipola; Esko Vanninen; Hannu J Aronen; Kirsi Lauerma; Sakari Simula; Pertti Jääskeläinen; Markku Laakso; Keijo Peuhkurinen; Johanna Kuusisto; Jyrki T Kuikka
Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(4):487-93.
2003: Minna Soinio; Markku Laakso; Seppo Lehto; Paula Hakala; Tapani Rönnemaa
Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes.
Diabetes care 2003;26(3):619-24.
2003: Frank Reimann; Hanna Huopio; Michael Dabrowski; Peter Proks; Fiona M Gribble; Markku Laakso; Timo Otonkoski; Frances M Ashcroft
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.
Diabetologia 2003;46(2):241-9.
2003: Leo Niskanen; Virpi Lindi; Arja T Erkkilä; Katariina Sivenius; Jukka S Luoma; Seppo Ylä-Herttuala; Markku Laakso; M I J Uusitupa
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects.
Metabolism: clinical and experimental 2003;52(2):213-7.
2003: Agata Kubaszek; Jussi Pihlajamäki; Pauli Karhapää; Ilkka Vauhkonen; Markku Laakso
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.
Diabetes care 2003;26(2):464-7.
2003: Agata Kubaszek; Jussi Pihlajamäki; Kari Punnonen; Pauli Karhapää; Ilkka Vauhkonen; Markku Laakso
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.
Diabetes 2003;52(2):558-61.
2003: Hanna Huopio; Timo Otonkoski; Ilkka Vauhkonen; Frank Reimann; Frances M Ashcroft; Markku Laakso
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
Lancet 2003;361(9354):301-7.
2003: Anne Lumiaho; Risto Ikäheimo; Jussi Pihlajamäki; Raija Miettinen; Lea Niemitukia; Ritva Vanninen; Erkki Lampainen; Markku Laakso
Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland.
Scandinavian journal of urology and nephrology 2003;37(4):352-8.
2003: Petri Sipola; Kirsi Lauerma; Minna Husso-Saastamoinen; Jyrki T Kuikka; Esko Vanninen; Tomi Laitinen; Hannu Manninen; Pekka Niemi; Keijo Peuhkurinen; Pertti Jääskeläinen; Markku Laakso; Johanna Kuusisto; Hannu J Aronen
First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene.
Radiology 2003;226(1):129-37.
2003: Maija Kossila; Jussi Pihlajamäki; Päivi Kärkkäinen; Raija Miettinen; Päivi Kekäläinen; Ilkka Vauhkonen; Seppo Ylä-Herttuala; Markku Laakso
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.
Diabetes care 2003;26(1):179-82.
2002: Hanna Mussalo; Esko Vanninen; Risto Ikäheimo; Tomi Laitinen; Markku Laakso; Esko Länsimies; Juha Hartikainen
Baroreflex sensitivity in essential and secondary hypertension.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2002;12(6):465-71.
2002: José L González-Sánchez; Manuel Serrano-Ríos; C Fernández Perez; Markku Laakso; María T Martínez Larrad
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(4):495-501.
2002: Hanna Huopio; Jarmo Jääskeläinen; Jorma Komulainen; Raija Miettinen; Päivi Kärkkäinen; Markku Laakso; Päivi Tapanainen; Raimo Voutilainen; Timo Otonkoski
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism.
The Journal of clinical endocrinology and metabolism 2002;87(10):4502-7.
2002: Juha Vakkilainen; Päivi Pajukanta; Rita M Cantor; Ilpo Nuotio; Sanni Lahdenperä; Kati Ylitalo; Jussi Pihlajamäki; Petri T Kovanen; Markku Laakso; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.
European journal of human genetics : EJHG 2002;10(9):547-52.
2002: Virpi Lindi; M I J Uusitupa; Jaana Lindström; Anne Louheranta; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Markku Laakso; Jaakko Tuomilehto
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.
Diabetes 2002;51(8):2581-6.
2002: Pia Pajunen; Mikko Syvänne; Markku S Nieminen; Anu Kareinen; Laura Viitanen; S Lehto; Markku Laakso
Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families.
European journal of clinical investigation 2002;32(7):472-8.
2002: Pertti Jääskeläinen; Johanna Kuusisto; Raija Miettinen; Päivi Kärkkäinen; Satu Kärkkäinen; Sami Heikkinen; Paula Peltola; Jussi Pihlajamäki; Ilkka Vauhkonen; Markku Laakso
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland.
Journal of molecular medicine (Berlin, Germany) 2002;80(7):412-22.
2002: Satu Kärkkäinen; Keijo Peuhkurinen; Pertti Jääskeläinen; Raija Miettinen; Päivi Kärkkäinen; Johanna Kuusisto; Markku Laakso
No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy.
American heart journal 2002;143(6):E6.
2002: Markku Laakso; Veikko Matilainen; Sirkka Keinänen-Kiukaanniemi
Association of neck circumference with insulin resistance-related factors.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(6):873-5.
2002: Arja T Erkkilä; Virpi Lindi; Seppo Lehto; K Pyörälä; Markku Laakso; M I J Uusitupa
Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2002;12(2):53-9.
2002: Seppo Lehto; Leo Niskanen; Matti Suhonen; Tapani Rönnemaa; Pekka Saikku; Markku Laakso
Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients.
Archives of internal medicine 2002;162(5):594-9.
2002: Arja T Erkkilä; Virpi Lindi; Seppo Lehto; Markku Laakso; M I J Uusitupa
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
Molecular genetics and metabolism 2002;75(3):260-4.
2002: Markku Laakso
Lipids in type 2 diabetes.
Seminars in vascular medicine 2002;2(1):59-66.
2002: Sakari Simula; Esko Vanninen; Laura Viitanen; Anu Kareinen; Seppo Lehto; Pia Pajunen; Mikko Syvänne; Jyrki Kuikka; Markku Laakso; Juha Hartikainen
Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(1):1-7.
2002: Hanna Huopio; Ilkka Vauhkonen; Jorma Komulainen; Leo Niskanen; Timo Otonkoski; Markku Laakso
Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion.
Diabetes care 2002;25(1):101-6.
2001: Laura Viitanen; Jussi Pihlajamäki; Raija Miettinen; Päivi Kärkkäinen; Ilkka Vauhkonen; P Halonen; Anu Kareinen; Seppo Lehto; Markku Laakso
Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease.
Journal of molecular medicine (Berlin, Germany) 2001;79(12):732-7.
2001: Anne Lumiaho; Risto Ikäheimo; Raija Miettinen; Lea Niemitukia; Tomi Laitinen; Arto Rantala; Erkki Lampainen; Markku Laakso; Juha Hartikainen
Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(6):1208-16.
2001: Katariina Sivenius; Virpi Lindi; Leo Niskanen; Markku Laakso; Matti Uusitupa
Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(11):1609-14.
2001: Jussi Pihlajamäki; M Austin; K Edwards; Markku Laakso
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia.
Diabetes 2001;50(10):2396-401.
2001: Hanna Mussalo; Esko Vanninen; Risto Ikäheimo; Tomi Laitinen; Markku Laakso; Esko Länsimies; Juha Hartikainen
Heart rate variability and its determinants in patients with severe or mild essential hypertension.
Clinical physiology (Oxford, England) 2001;21(5):594-604.
2001: Johanna Kuusisto; P Lempiäinen; Leena Mykkänen; Markku Laakso
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.
Diabetes care 2001;24(9):1629-33.
2001: Anu Kareinen; Laura Viitanen; P Halonen; Seppo Lehto; Markku Laakso
Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(8):1346-52.
2001: H Wang; J Rissanen; Raija Miettinen; Päivi Kärkkäinen; Päivi Kekäläinen; Johanna Kuusisto; Leena Mykkänen; Pauli Karhapää; Markku Laakso
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes 2001;50(8):1949-51.
2001: Virpi Lindi; Katariina Sivenius; Leo Niskanen; Markku Laakso; M I J Uusitupa
Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects.
Diabetologia 2001;44(7):925-6.
2001: Laura Viitanen; Jussi Pihlajamäki; P Halonen; Marko Lehtonen; Anu Kareinen; Seppo Lehto; Markku Laakso
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease.
Atherosclerosis 2001;157(1):57-64.
2001: Jussi Pihlajamäki; RH Valve; L Karjalainen; Pauli Karhapää; Ilkka Vauhkonen; Markku Laakso
The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance.
European journal of clinical investigation 2001;31(4):302-8.
2001: Arja T Erkkilä; Essi S Sarkkinen; Virpi Lindi; Seppo Lehto; Markku Laakso; M I J Uusitupa
APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose.
The American journal of clinical nutrition 2001;73(4):746-52.
2001: Matti Vanhanen; Miia Kivipelto; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; Kari Kervinen; Y Antero Kesäniemi; Mikko P Laakso; Hilkka Soininen; Markku Laakso
APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
Neurology 2001;56(5):655-9.
2001: Markku Laakso
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention.
Journal of internal medicine 2001;249(3):225-35.
2001: Jyrki J Agren; Helvi M Vidgren; R S Valve; Markku Laakso; M I J Uusitupa
Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene.
The American journal of clinical nutrition 2001;73(1):31-5.
2000: SM Mustanoja; T Hätönen; Aino Alila-Johansson; Markku Laakso
Evidence for central alpha(2)-adrenergic modulation of rat pineal melatonin synthesis.
Brain research 2000;887(1):174-7.
2000: Ulla Rajala; foxiao qiao; Markku Laakso; Sirkka Keinänen-Kiukaanniemi
Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance.
Diabetes research and clinical practice 2000;50(3):231-9.
2000: Niki Lindblom; T Hätönen; Markku Laakso; Aino Alila-Johansson; M Laipio; Ursula Turpeinen
Bright light exposure of a large skin area does not affect melatonin or bilirubin levels in humans.
Biological psychiatry 2000;48(11):1098-104.
2000: Päivi Pajukanta; M Cargill; Laura Viitanen; Ilpo Nuotio; Anu Kareinen; Markus Perola; Joseph D Terwilliger; E Kempas; Mark J Daly; Heidi E Lilja; JD Rioux; T Brettin; Jorma S A Viikari; T Rönnemaa; Markku Laakso; Eric S Lander; Leena Peltonen
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
American journal of human genetics 2000;67(6):1481-93.
2000: Anne Maria Koivisto; P Lempiäinen; Keijo Koivisto; Eeva-Liisa Helkala; Leena Mykkänen; Johanna Kuusisto; Kari Kervinen; Y Antero Kesäniemi; Markku Laakso; Hilkka Soininen
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
Neuroepidemiology 2000;19(6):327-32.
2000: Päivi Kekäläinen; H Sarlund; Markku Laakso
Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance.
Metabolism: clinical and experimental 2000;49(10):1247-54.
2000: J Rissanen; H Wang; Raija Miettinen; Päivi Kärkkäinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Pauli Karhapää; Leo Niskanen; Matti Uusitupa; Markku Laakso
Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes care 2000;23(10):1533-8.
2000: Hanna Huopio; Frank Reimann; R Ashfield; Jorma Komulainen; H L Lenko; Jacques Rahier; Ilkka Vauhkonen; Juha Kere; Markku Laakso; Frances M Ashcroft; Timo Otonkoski
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
The Journal of clinical investigation 2000;106(7):897-906.
2000: Maija Kossila; M Sinkovic; Päivi Kärkkäinen; Mikko O Laukkanen; Raija Miettinen; J Rissanen; Päivi Kekäläinen; Johanna Kuusisto; Seppo Ylä-Herttuala; Markku Laakso
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes 2000;49(10):1740-3.
2000: M Pyörälä; H Miettinen; Markku Laakso; Kalevi Pyörälä
Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study.
Diabetes care 2000;23(8):1097-102.
2000: Jussi Pihlajamäki; Raija Miettinen; RH Valve; L Karjalainen; Leena Mykkänen; Johanna Kuusisto; Samir S Deeb; Johan Auwerx; Markku Laakso
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.
Atherosclerosis 2000;151(2):567-74.
2000: Ilkka Vauhkonen; Leo Niskanen; Leena Mykkänen; Steven M Haffner; M I J Uusitupa; Markku Laakso
Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(2):251-60.
2000: Jussi Pihlajamäki; L Karjalainen; Pauli Karhapää; Ilkka Vauhkonen; M R Taskinen; Samir S Deeb; Markku Laakso
G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1789-95.
2000: Leo Niskanen; Matti K Karvonen; RH Valve; Markku Koulu; Ullamari Pesonen; M Mercuri; Rainer Rauramaa; Jari Töyry; Markku Laakso; M I J Uusitupa
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
The Journal of clinical endocrinology and metabolism 2000;85(6):2266-9.
2000: A Pulkkinen; Laura Viitanen; Anu Kareinen; Seppo Lehto; Markku Laakso
Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes.
Diabetes care 2000;23(6):864.
2000: A Pulkkinen; Laura Viitanen; Anu Kareinen; Seppo Lehto; Markku Laakso
MspI polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of HDL cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic patients with coronary heart disease.
Diabetes care 2000;23(6):791-5.
2000: Katariina Sivenius; RH Valve; Virpi Lindi; Leo Niskanen; Markku Laakso; Matti Uusitupa
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(4):514-9.
2000: Seppo Lehto; T Rönnemaa; Kalevi Pyörälä; Markku Laakso
Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes.
Diabetologia 2000;43(2):148-55.
2000: M Pyörälä; H Miettinen; P Halonen; Markku Laakso; Kalevi Pyörälä
Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):538-44.
2000: Sami Heikkinen; Suvikki Suppola; Mari Malkki; Samir S Deeb; Juhani Jänne; Markku Laakso
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):91-6.
2000: M Laitinen; Juha Hartikainen; Mikko O Hiltunen; Jaakko Eränen; M Kiviniemi; Outi Närvänen; Kimmo Mäkinen; Hannu Manninen; Mikko Syvänne; John F Martin; Markku Laakso; Seppo Ylä-Herttuala
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty.
Human gene therapy 2000;11(2):263-70.
2000: A Pulkkinen; Laura Viitanen; Anu Kareinen; Seppo Lehto; Ilkka Vauhkonen; Markku Laakso
Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease.
Journal of molecular medicine (Berlin, Germany) 2000;78(7):372-9.
2000: Leo Niskanen; Raija Voutilainen-Kaunisto; Markku Teräsvirta; Matti K Karvonen; RH Valve; Ullamari Pesonen; Markku Laakso; M I J Uusitupa; Markku Koulu
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2000;108(3):235-6.
2000: J Rissanen; Ari Markkanen; Päivi Kärkkäinen; Jussi Pihlajamäki; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Pauli Karhapää; Leo Niskanen; Markku Laakso
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.
Diabetes care 2000;23(1):70-3.
2000: Ilkka Vauhkonen; Leo Niskanen; Mikael Knip; J Ilonen; Esko Vanninen; Sakari Kainulainen; Matti Uusitupa; Markku Laakso
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults.
Diabetologia 2000;43(1):69-78.
2000: Jussi Pihlajamäki; L Karjalainen; Pauli Karhapää; Ilkka Vauhkonen; Markku Laakso
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):164-70.
1999: Pertti Jääskeläinen; Raija Miettinen; K Silvennoinen; Ilkka Vauhkonen; Markku Laakso; Johanna Kuusisto
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from eastern Finland.
Journal of molecular and cellular cardiology 1999;31(11):2031-6.
1999: RH Valve; Katariina Sivenius; Raija Miettinen; Jussi Pihlajamäki; Aila Rissanen; Samir S Deeb; Johan Auwerx; Matti Uusitupa; Markku Laakso
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.
The Journal of clinical endocrinology and metabolism 1999;84(10):3708-12.
1999: J Sivenius; L Cunha; H C Diener; C Forbes; Markku Laakso; A Lowenthal; P Smets; PJ Riekkinen
Antiplatelet treatment does not reduce the severity of subsequent stroke. European Stroke Prevention Study 2 Working Group.
Neurology 1999;53(4):825-9.
1999: Tero Tikanoja; Pertti Jääskeläinen; Markku Laakso; Johanna Kuusisto
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children.
The American journal of cardiology 1999;84(4):485-6.
1999: Sami Heikkinen; Marko Pietilä; Maria Halmekytö; Suvikki Suppola; Eija Pirinen; Samir S Deeb; Juhani Jänne; Markku Laakso
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
The Journal of biological chemistry 1999;274(32):22517-23.
1999: Hannele Laivuori; Markku Laakso; Matti J Tikkanen; Bruno Cacciatore; R O Ylikorkala; Risto Kaaja
Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia.
Journal of hypertension 1999;17(8):1189-94.
1999: P Lempiäinen; Leena Mykkänen; Kalevi Pyörälä; Markku Laakso; Johanna Kuusisto
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.
Circulation 1999;100(2):123-8.
1999: Risto Kaaja; Hannele Laivuori; Markku Laakso; Matti J Tikkanen; Olavi Ylikorkala
Evidence of a state of increased insulin resistance in preeclampsia.
Metabolism: clinical and experimental 1999;48(7):892-6.
1999: A Pulkkinen; Anu Kareinen; L Saarinen; Sami Heikkinen; Seppo Lehto; Markku Laakso
The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients.
Metabolism: clinical and experimental 1999;48(7):853-6.
1999: Petri Heinonen; Markku Koulu; Ullamari Pesonen; Matti K Karvonen; Aila Rissanen; Markku Laakso; RH Valve; Matti Uusitupa; Mika Scheinin
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.
The Journal of clinical endocrinology and metabolism 1999;84(7):2429-33.
1999: M Overmyer; Seppo Helisalmi; Hilkka Soininen; Markku Laakso; PJ Riekkinen; Irina Alafuzoff
Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.
Dementia and geriatric cognitive disorders 1999;10(4):252-7.
1999: J Kuusisto; Markku Laakso
Prandial glucose regulation and cardiovascular disease in type 2 diabetes.
European journal of clinical investigation 1999;29 Suppl 2():7-11.
1999: Tomi Laitinen; Ilkka Vauhkonen; Leo Niskanen; Juha E K Hartikainen; Esko Länsimies; M I J Uusitupa; Markku Laakso
Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects.
Diabetes 1999;48(6):1295-9.
1999: Markku Laakso
Hyperglycemia and cardiovascular disease in type 2 diabetes.
Diabetes 1999;48(5):937-42.
1999: Päivi Pajukanta; Joseph D Terwilliger; Markus Perola; Tero Hiekkalinna; Ilpo Nuotio; Pekka Ellonen; Maija Parkkonen; Jaana Hartiala; Kati Ylitalo; Jussi Pihlajamäki; Kimmo Porkka; Markku Laakso; Jorma Viikari; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
American journal of human genetics 1999;64(5):1453-63.
1999: M Overmyer; Seppo Helisalmi; Hilkka Soininen; Markku Laakso; PJ Riekkinen; Irina Alafuzoff
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
Acta neuropathologica 1999;97(4):383-92.
1999: Seppo Lehto; T Rönnemaa; Kalevi Pyörälä; Markku Laakso
Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):1014-9.
1999: Leo Niskanen; Matti Uusitupa; Markku Laakso
[Drug therapy of hyperglycemia and the prognosis of adult-onset diabetes mellitus].
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1122-4.
1999: Johanna Kuusisto; Pertti Jääskeläinen; Markku Laakso
[Sarcomere gene mutations--a cause of hypertrophic cardiomyopathy].
Duodecim; lääketieteellinen aikakauskirja 1999;115(9):997-8.
1999: Päivi Kekäläinen; H Sarlund; Kalevi Pyörälä; Markku Laakso
Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes.
Diabetes care 1999;22(1):86-92.
1998: Ilkka Vauhkonen; Leo Niskanen; Steven M Haffner; Sakari Kainulainen; Matti Uusitupa; Markku Laakso
Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(6):598-604.
1998: Pertti Jääskeläinen; M Soranta; Raija Miettinen; L Saarinen; Jussi Pihlajamäki; K Silvennoinen; Tero Tikanoja; Markku Laakso; Johanna Kuusisto
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.
Journal of the American College of Cardiology 1998;32(6):1709-16.
1998: Jussi Pihlajamäki; J Rissanen; RH Valve; Sami Heikkinen; L Karjalainen; Markku Laakso
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia.
Metabolism: clinical and experimental 1998;47(11):1397-402.
1998: Mari Malkki; Markku Laakso; Samir S Deeb
Functional consequences of naturally occurring variants of human hexokinase II.
Diabetologia 1998;41(10):1205-9.
1998: Ulla Rajala; Markku Laakso; foxiao qiao; Sirkka Keinänen-Kiukaanniemi
Prevalence of retinopathy in people with diabetes, impaired glucose tolerance, and normal glucose tolerance.
Diabetes care 1998;21(10):1664-9.
1998: Jyrki J Agren; RH Valve; Helvi M Vidgren; Markku Laakso; Matti Uusitupa
Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1606-10.
1998: L Karjalainen; Jussi Pihlajamäki; Pauli Karhapää; Markku Laakso
Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1548-53.
1998: Matti K Karvonen; Ullamari Pesonen; Petri Heinonen; Markku Laakso; Aila Rissanen; Hannu Naukkarinen; RH Valve; M I J Uusitupa; Markku Koulu
Identification of new sequence variants in the leptin gene.
The Journal of clinical endocrinology and metabolism 1998;83(9):3239-42.
1998: M Pyörälä; H Miettinen; Markku Laakso; Kalevi Pyörälä
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Stroke; a journal of cerebral circulation 1998;29(9):1860-6.
1998: M Pyörälä; H Miettinen; Markku Laakso; Kalevi Pyörälä
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Circulation 1998;98(5):398-404.
1998: M Laitinen; Kimmo Mäkinen; Hannu Manninen; Pekka J Matsi; Maija Kossila; RS Agrawal; Timo Pakkanen; Jukka S Luoma; Helena Viita; Juha Hartikainen; Esko Alhava; Markku Laakso; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia.
Human gene therapy 1998;9(10):1481-6.
1998: J Rissanen; L Saarinen; Sami Heikkinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; Samir S Deeb; Markku Laakso
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
Diabetes care 1998;21(7):1194-7.
1998: L Saarinen; A Pulkkinen; Anu Kareinen; Sami Heikkinen; Seppo Lehto; Markku Laakso
Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.
Diabetes care 1998;21(5):849-50.
1998: Markku Laakso; Seppo Lehto
Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance.
Atherosclerosis 1998;137 Suppl():S65-73.
1998: Markku Laakso
Hypertension and macrovascular disease--the killing fields of NIDDM.
Diabetes research and clinical practice 1998;39 Suppl():S27-33.
1998: Matti J Tikkanen; Markku Laakso; Maritta Ilmonen; E Helve; E Kaarsalo; E Kilkki; J Saltevo
Treatment of hypercholesterolemia and combined hyperlipidemia with simvastatin and gemfibrozil in patients with NIDDM. A multicenter comparison study.
Diabetes care 1998;21(4):477-81.
1998: Päivi Pajukanta; Ilpo Nuotio; Joseph D Terwilliger; Kimmo Porkka; Kati Ylitalo; Jussi Pihlajamäki; Anu Suomalainen; Ann-Christine Syvänen; T Lehtimäki; Jorma S A Viikari; Markku Laakso; Marja-Riitta Taskinen; Christian Ehnholm; Leena Peltonen
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Nature genetics 1998;18(4):369-73.
1998: RH Valve; Sami Heikkinen; Aila Rissanen; Markku Laakso; Matti Uusitupa
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns.
Diabetologia 1998;41(3):357-61.
1998: Matti Vanhanen; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; PJ Riekkinen; Hilkka Soininen; Markku Laakso
Cognitive function in an elderly population with persistent impaired glucose tolerance.
Diabetes care 1998;21(3):398-402.
1998: S Lehto; Leo Niskanen; T Rönnemaa; Markku Laakso
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus.
Stroke; a journal of cerebral circulation 1998;29(3):635-9.
1998: Mervi S Riekkinen; Hilkka Soininen; PJ Riekkinen; J Kuikka; Markku Laakso; Eeva-Liisa Helkala; J Partanen; P Riekkinen
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.
Neuroscience 1998;83(2):471-9.
1998: Ilkka Vauhkonen; Leo Niskanen; Esko Vanninen; Sakari Kainulainen; Matti Uusitupa; Markku Laakso
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands.
The Journal of clinical investigation 1998;101(1):86-96.
1997: J Rissanen; Jussi Pihlajamäki; Sami Heikkinen; Päivi Kekäläinen; Leena Mykkänen; Johanna Kuusisto; A Kolle; Markku Laakso
New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.
Diabetologia 1997;40(11):1313-9.
1997: Johanna Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Matti Vanhanen; Tuomo Hänninen; Kari Kervinen; Y Antero Kesäniemi; PJ Riekkinen; Markku Laakso
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.
BMJ (Clinical research ed.) 1997;315(7115):1045-9.
1997: M Laitinen; Ian Zachary; Georg Breier; Timo Pakkanen; Tomi P Häkkinen; Jukka S Luoma; H Abedi; Werner Risau; M Soma; Markku Laakso; John F Martin; Seppo Ylä-Herttuala
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries.
Human gene therapy 1997;8(15):1737-44.
1997: PJ Riekkinen; Ari Pääkkönen; Jari Karhu; J Partanen; Hilkka Soininen; Markku Laakso; P Riekkine
THA disrupts mismatch negativity in Alzheimer disease.
Psychopharmacology 1997;133(2):203-6.
1997: Leena Mykkänen; Steven M Haffner; Tapani Rönnemaa; R N Bergman; Markku Laakso
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.
American journal of epidemiology 1997;146(4):315-21.
1997: RH Sipiläinen; Matti Uusitupa; Sami Heikkinen; Aila Rissanen; Markku Laakso
Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects.
The Journal of clinical endocrinology and metabolism 1997;82(8):2629-32.
1997: J Rissanen; J Kuopusjärvi; Jussi Pihlajamäki; RH Sipiläinen; Sami Heikkinen; Mauno Vanhala; Päivi Kekäläinen; Johanna Kuusisto; Markku Laakso
The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome.
Diabetes care 1997;20(8):1319-23.
1997: S Lehto; T Rönnemaa; Steven M Haffner; K Pyörälä; V Kallio; Markku Laakso
Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM.
Diabetes 1997;46(8):1354-9.
1997: Pekka Jäkälä; Tuomo Hänninen; Markku Ryynänen; Markku Laakso; Kaarina Partanen; Arto Mannermaa; Hilkka Soininen
Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
The Journal of clinical investigation 1997;100(2):331-8.
1997: Jussi Pihlajamäki; J Rissanen; Sami Heikkinen; L Karjalainen; Markku Laakso
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(6):1039-44.
1997: PJ Riekkinen; Mervi S Riekkinen; Hilkka Soininen; J Kuikka; Markku Laakso; P Riekkinen
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease.
Neuroreport 1997;8(8):1845-9.
1997: Helvi M Vidgren; RH Sipiläinen; Sami Heikkinen; Markku Laakso; M I J Uusitupa
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects.
European journal of clinical investigation 1997;27(5):405-8.
1997: Matti Vanhanen; Keijo Koivisto; L Karjalainen; Eeva-Liisa Helkala; Markku Laakso; Hilkka Soininen; PJ Riekkinen
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function.
Neuroreport 1997;8(6):1527-30.
1997: J Rissanen; Jussi Pihlajamäki; Sami Heikkinen; Päivi Kekäläinen; Johanna Kuusisto; Markku Laakso
The Ala54Thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects.
Diabetes 1997;46(4):711-2.
1997: J Mustonen; M Uusitupa; M Mäntysaari; E Länsimies; K Pyörälä; Markku Laakso
Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease.
Journal of internal medicine 1997;241(3):227-35.
1997: RH Sipiläinen; Matti Uusitupa; Sami Heikkinen; Aila Rissanen; Markku Laakso
Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns.
Diabetes 1997;46(1):77-80.
1996: H Miettinen; Steven M Haffner; Seppo Lehto; T Rönnemaa; K Pyörälà; Markku Laakso
Retinopathy predicts coronary heart disease events in NIDDM patients.
Diabetes care 1996;19(12):1445-8.
1996: Matti Vanhanen; Jari Karhu; Keijo Koivisto; Ari Pääkkönen; Juhani Partanen; Markku Laakso; PJ Riekkinen
ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM.
Neuroreport 1996;7(15-17):2767-71.
1996: Tapani Rönnemaa; E M Rönnemaa; P Puukka; K Pyörälä; Markku Laakso
Smoking is independently associated with high plasma insulin levels in nondiabetic men.
Diabetes care 1996;19(11):1229-32.
1996: H Miettinen; Steven M Haffner; Seppo Lehto; T Rönnemaa; Kalevi Pyörälä; Markku Laakso
Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects.
Stroke; a journal of cerebral circulation 1996;27(11):2033-9.
1996: P Kekäläinen; H Sarlund; P Farin; E Kaukanen; Xiaoming Yang; Markku Laakso
Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance.
American journal of epidemiology 1996;144(8):742-8.
1996: Markku Laakso; Johanna Kuusisto
Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus.
Annals of medicine 1996;28(5):415-8.
1996: Markku Laakso; L Karjalainen; P Lempiäinen-Kuosa
Effects of losartan on insulin sensitivity in hypertensive subjects.
Hypertension 1996;28(3):392-6.
1996: Markku Laakso
Insulin resistance and coronary heart disease.
Current opinion in lipidology 1996;7(4):217-26.
1996: Markku Laakso
Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus.
Annals of medicine 1996;28(4):341-5.
1996: Seppo Lehto; Leo Niskanen; M Suhonen; T Rönnemaa; Markku Laakso
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):978-83.
1996: P Kekäläinen; H Sarlund; Kalevi Pyörälä; Markku Laakso
Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus.
Atherosclerosis 1996;123(1-2):203-13.
1996: Seppo Lehto; T Rönnemaa; Kalevi Pyörälä; Markku Laakso
Risk factors predicting lower extremity amputations in patients with NIDDM.
Diabetes care 1996;19(6):607-12.
1996: T Hanninen; Keijo Koivisto; K J Reinikainen; Eeva-Liisa Helkala; Hilkka Soininen; L Mykkänen; Markku Laakso; PJ Riekkinen
Prevalence of ageing-associated cognitive decline in an elderly population.
Age and ageing 1996;25(3):201-5.
1996: L Mykkanen; Steven M Haffner; T Ronnemaa; Richard Watanabe; Markku Laakso
Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity?
Journal of hypertension 1996;14(3):399-405.
1996: Eeva-Liisa Helkala; Keijo Koivisto; T Hanninen; Matti Vanhanen; K Kervinen; Johanna Kuusisto; L Mykkanen; Y A Kesaniemi; Markku Laakso; PJ Riekkinen
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study.
Neuroscience letters 1996;204(3):177-80.
1996: Leo Niskanen; Matti Uusitupa; H Sarlund; O Siitonen; L Paljärvi; Markku Laakso
The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(2):154-60.
1996: Seppo Lehto; T Rönnemaa; Kalevi Pyörälä; Markku Laakso
Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes.
Stroke; a journal of cerebral circulation 1996;27(1):63-8.
1995: Leena Mykkänen; Steven M Haffner; Johanna Kuusisto; Kalevi Pyörälä; C N Hales; Markku Laakso
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects.
Diabetologia 1995;38(10):1176-82.
1995: Melissa A Austin; L Mykkänen; Johanna Kuusisto; Karen L Edwards; C Nelson; Steven M Haffner; K Pyörälä; Markku Laakso
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women.
Circulation 1995;92(7):1770-8.
1995: Johanna Kuusisto; Leena Mykkänen; K Kervinen; Y A Kesäniemi; Markku Laakso
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(9):1280-6.
1995: Tuomo Hänninen; Merja Hallikainen; Keijo Koivisto; Eeva-Liisa Helkala; K J Reinikainen; Hilkka Soininen; L Mykkänen; Markku Laakso; Kalevi Pyörälä; PJ Riekkinen
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.
Journal of the American Geriatrics Society 1995;43(9):1007-15.
1995: Leo Niskanen; H Sarlund; Markku Laakso
Metabolic defects in persistent impaired glucose tolerance are related to the family history of non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1995;44(8):1099-104.
1995: PJ Riekkinen; Hilkka Soininen; Eeva-Liisa Helkala; Kaarina Partanen; Markku Laakso; Matti Vanhanen; P Riekkinen
Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease.
Neuroreport 1995;6(9):1297-300.
1995: Eeva-Liisa Helkala; Keijo Koivisto; Tuomo Hänninen; Matti Vanhanen; K Kervinen; Johanna Kuusisto; Leena Mykkänen; Y A Kesäniemi; Markku Laakso; PJ Riekkinen
The association of apolipoprotein E polymorphism with memory: a population based study.
Neuroscience letters 1995;191(3):141-4.
1995: Jukka Virtaniemi; Johanna Kuusisto; L Karjalainen; S Karjalainen; Markku Laakso
Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus.
American journal of otolaryngology 1995;16(3):172-6.
1995: Markku Laakso; Mari Malkki; Päivi Kekäläinen; Johanna Kuusisto; Samir S Deeb
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Diabetologia 1995;38(5):617-22.
1995: Markku Laakso; T Rönnemaa; Seppo Lehto; P Puukka; V Kallio; Kalevi Pyörälä
Does NIDDM increase the risk for coronary heart disease similarly in both low- and high-risk populations?
Diabetologia 1995;38(4):487-93.
1995: Keijo Koivisto; K J Reinikainen; Tuomo Hänninen; Matti Vanhanen; Eeva-Liisa Helkala; L Mykkänen; Markku Laakso; Kalevi Pyörälä; PJ Riekkinen
Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland.
Neurology 1995;45(4):741-7.
1995: Markku Laakso; Hilkka Soininen; Kaarina Partanen; Merja Hallikainen; Maarit Lehtovirta; Tuomo Hänninen; Pauli Vainio; PJ Riekkinen
The interuncal distance in Alzheimer disease and age-associated memory impairment.
AJNR. American journal of neuroradiology 1995;16(4):727-34.
1995: Markku Laakso; Mari Malkki; Samir S Deeb
Amino acid substitutions in hexokinase II among patients with NIDDM.
Diabetes 1995;44(3):330-4.
1995: Markku Laakso; Mari Malkki; Päivi Kekäläinen; Johanna Kuusisto; Leena Mykkänen; Samir S Deeb
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
Diabetes care 1995;18(3):398-400.
1995: Johanna Kuusisto; L Mykkänen; Kalevi Pyörälä; Markku Laakso
Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease.
Circulation 1995;91(3):831-7.
1995: Juhani Sivenius; PJ Riekkinen; Markku Laakso
Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes.
BMJ (Clinical research ed.) 1995;310(6971):25-6.
1994: L Mykkänen; Johanna Kuusisto; K Pyörälä; Markku Laakso; Steven M Haffner
Increased risk of non-insulin-dependent diabetes mellitus in elderly hypertensive subjects.
Journal of hypertension 1994;12(12):1425-32.
1994: Mari Malkki; Markku Laakso; Samir S Deeb
Structure of the human hexokinase II gene.
Biochemical and biophysical research communications 1994;205(1):490-6.
1994: Jukka Virtaniemi; Markku Laakso; Juhani Nuutinen; S Karjalainen; E Vartiainen
Hearing thresholds in insulin-dependent diabetic patients.
The Journal of laryngology and otology 1994;108(10):837-41.
1994: Pekka J Matsi; Hannu Manninen; Markku Laakso; P Jaakkola
Impact of risk factors on limb salvage after angioplasty in chronic critical lower limb ischemia. A prospective trial.
Angiology 1994;45(9):797-804.
1994: Markku Laakso; Mari Malkki; Päivi Kekäläinen; Johanna Kuusisto; Samir S Deeb
Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.
The Journal of clinical investigation 1994;94(3):1141-6.
1994: Leena Mykkänen; T Rönnemaa; J Marniemi; Steven M Haffner; R Bergman; Markku Laakso
Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1264-71.
1994: Johanna Kuusisto; L Mykkänen; K Pyörälä; Markku Laakso
NIDDM and its metabolic control predict coronary heart disease in elderly subjects.
Diabetes 1994;43(8):960-7.
1994: J N Mustonen; M I J Uusitupa; Markku Laakso; Esko Vanninen; Esko Länsimies; Jyrki T Kuikka; Kalevi Pyörälä
Left ventricular systolic function in middle-aged patients with diabetes mellitus.
The American journal of cardiology 1994;73(16):1202-8.
1994: Johanna Kuusisto; L Mykkänen; Kalevi Pyörälä; Markku Laakso
Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly subjects.
Stroke; a journal of cerebral circulation 1994;25(6):1157-64.
1994: Pekka J Matsi; Hannu Manninen; Ritva Vanninen; M T Suhonen; I Oksala; Markku Laakso; T Hakkarainen; Seppo Soimakallio
Femoropopliteal angioplasty in patients with claudication: primary and secondary patency in 140 limbs with 1-3-year follow-up.
Radiology 1994;191(3):727-33.
1994: L Mykkänen; Steven M Haffner; T Rönnemaa; R Bergman; A Leino; Markku Laakso
Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins?
Metabolism: clinical and experimental 1994;43(4):523-8.
1994: Leena Mykkänen; Johanna Kuusisto; Steven M Haffner; Kalevi Pyörälä; Markku Laakso
Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(4):518-26.
1994: L Mykkänen; Steven M Haffner; Johanna Kuusisto; K Pyorälä; Markku Laakso
Microalbuminuria precedes the development of NIDDM.
Diabetes 1994;43(4):552-7.
1994: P Karhapää; Mari Malkki; Markku Laakso
Isolated low HDL cholesterol. An insulin-resistant state.
Diabetes 1994;43(3):411-7.
1994: Jukka Virtaniemi; Markku Laakso; Juhani Nuutinen; S Karjalainen; E Vartiainen
Acoustic-reflex responses in patients with insulin-dependent diabetes mellitus.
American journal of otolaryngology 1994;15(2):109-13.
1994: Tuomo Hänninen; K J Reinikainen; Eeva-Liisa Helkala; Keijo Koivisto; L Mykkänen; Markku Laakso; Kalevi Pyörälä; PJ Riekkinen
Subjective memory complaints and personality traits in normal elderly subjects.
Journal of the American Geriatrics Society 1994;42(1):1-4.
1993: Leo Niskanen; Markku Laakso
Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus.
Metabolism: clinical and experimental 1993;42(12):1541-5.
1993: Samir S Deeb; Mari Malkki; Markku Laakso
Human hexokinase II: sequence and homology to other hexokinases.
Biochemical and biophysical research communications 1993;197(1):68-74.
1993: Jukka Virtaniemi; Markku Laakso; J Kärjä; Juhani Nuutinen; S Karjalainen
Auditory brainstem latencies in type I (insulin-dependent) diabetic patients.
American journal of otolaryngology 1993;14(6):413-8.
1993: Johanna Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Matti Vanhanen; Tuomo Hänninen; Kalevi Pyörälä; PJ Riekkinen; Markku Laakso
Essential hypertension and cognitive function. The role of hyperinsulinemia.
Hypertension 1993;22(5):771-9.
1993: Markku Laakso; Seppo Lehto; I Penttilä; Kalevi Pyörälä
Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes.
Circulation 1993;88(4 Pt 1):1421-30.
1993: P Karhapää; E Voutilainen; Mari Malkki; Markku Laakso
Obese men with type IIB hyperlipidemia are insulin resistant.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(10):1469-75.
1993: Juhani Sivenius; PJ Riekkinen; A Lowenthal; P Smets; Markku Laakso
Antiplatelet therapy is effective in primary prevention of myocardial infarction in patients with a previous cerebrovascular ischemic event.
Archives of neurology 1993;50(7):710-3.
1993: Ursula S Schwab; Matti Uusitupa; P Karhapää; Sari Mäkimattila; M Räsänen; E Mäkinen; Markku Laakso
Effects of two fat-modified diets on glucose and lipid metabolism in healthy subjects.
Annals of the New York Academy of Sciences 1993;683():279-80.
1993: Leena Mykkänen; Johanna Kuusisto; Kalevi Pyörälä; Markku Laakso
Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects.
Diabetologia 1993;36(6):553-9.
1993: Leena Mykkänen; Markku Laakso; Kalevi Pyörälä
High plasma insulin level associated with coronary heart disease in the elderly.
American journal of epidemiology 1993;137(11):1190-202.
1993: O Ukkola; K Kervinen; Pasi Salmela; K von Dickhoff; Markku Laakso; Y Antero Kesäniemi
Apolipoprotein E phenotype is related to macro- and microangiopathy in patients with non-insulin-dependent diabetes mellitus.
Atherosclerosis 1993;101(1):9-15.
1993: Markku Laakso
How good a marker is insulin level for insulin resistance?
American journal of epidemiology 1993;137(9):959-65.
1993: J Mustonen; Markku Laakso; T Hirvonen; O Mutru; M Pirnes; P Vainio; Jyrki T Kuikka; Pentti J Rautio; Esko Länsimies
Abnormalities in left ventricular diastolic function in male patients with rheumatoid arthritis without clinically evident cardiovascular disease.
European journal of clinical investigation 1993;23(4):246-53.
1993: Jukka Virtaniemi; Markku Laakso; Juhani Nuutinen; S Karjalainen; E Vartiainen
Voluntary eye movement tests in patients with insulin-dependent diabetes mellitus.
Acta oto-laryngologica 1993;113(2):123-7.
1993: Juhani Sivenius; PJ Riekkinen; Markku Laakso; P Smets; A Lowenthal
European Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderly.
Acta neurologica Scandinavica 1993;87(2):111-4.
1993: O I Siitonen; L K Niskanen; Markku Laakso; J T Siitonen; Kalevi Pyörälä
Lower-extremity amputations in diabetic and nondiabetic patients. A population-based study in eastern Finland.
Diabetes care 1993;16(1):16-20.
1993: P Karhapää; E Voutilainen; Petri Kovanen; Markku Laakso
Insulin resistance in familial and nonfamilial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):41-7.
1993: Jukka Virtaniemi; Markku Laakso; Juhani Nuutinen; S Karjalainen; E Vartiainen
Tympanometry in patients with insulin-dependent diabetes mellitus.
Scandinavian audiology 1993;22(4):217-22.
1992: Markku Laakso
Dyslipidaemias, insulin resistance and atherosclerosis.
Annals of medicine 1992;24(6):505-9.
1992: P Karhapää; Matti Uusitupa; E Voutilainen; Markku Laakso
Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia.
Clinical pharmacology and therapeutics 1992;52(6):620-6.
1992: L Mykkänen; Markku Laakso; K Pyörälä
Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1992;16(9):695-704.
1992: Leena Mykkänen; Markku Laakso; Kalevi Pyörälä
Asymptomatic hyperglycemia and atherosclerotic vascular disease in the elderly.
Diabetes care 1992;15(8):1020-30.
1992: Keijo Koivisto; Eeva-Liisa Helkala; K J Reinikainen; Tuomo Hänninen; L Mykkänen; Markku Laakso; Kalevi Pyörälä; PJ Riekkinen
Population-based dementia screening program in Kuopio: the effect of education, age, and sex on brief neuropsychological tests.
Journal of geriatric psychiatry and neurology 1992;5(3):162-71.
1992: M I J Uusitupa; L Mykkänen; O Siitonen; Markku Laakso; H Sarlund; P Kolehmainen; T Räsänen; J Kumpulainen; Kalevi Pyörälä
Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels.
The British journal of nutrition 1992;68(1):209-16.
1992: Juhani Sivenius; Markku Laakso; PJ Riekkinen; P Smets; A Lowenthal
European stroke prevention study: effectiveness of antiplatelet therapy in diabetic patients in secondary prevention of stroke.
Stroke; a journal of cerebral circulation 1992;23(6):851-4.
1992: H Sarlund; Kalevi Pyörälä; I Penttilä; Markku Laakso
Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(6):657-63.
1991: Markku Laakso; A Kesäniemi; K Kervinen; M Jauhiainen; Kalevi Pyörälä
Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes.
BMJ (Clinical research ed.) 1991;303(6811):1159-62.
1991: Juhani Sivenius; PJ Riekkinen; H Kilpeläinen; Markku Laakso; I Penttilä
Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European Stroke Prevention Study (ESPS).
Acta neurologica Scandinavica 1991;84(4):286-90.
1991: Juhani Sivenius; Markku Laakso; I M Penttilä; P Smets; A Lowenthal; PJ Riekkinen
The European Stroke Prevention Study: results according to sex.
Neurology 1991;41(8):1189-92.
1991: Markku Laakso; H Sarlund; Riitta Salonen; M Suhonen; Kalevi Pyörälä; Jukka T Salonen; P Karhapää
Asymptomatic atherosclerosis and insulin resistance.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):1068-76.
1991: L Mykkänen; Markku Laakso; I Penttilä; Kalevi Pyörälä
Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly.
Atherosclerosis 1991;88(2-3):153-61.
1991: Juhani Sivenius; PJ Riekkinen; P Smets; Markku Laakso; A Lowenthal
The European Stroke Prevention Study (ESPS): results by arterial distribution.
Annals of neurology 1991;29(6):596-600.
1991: Markku Laakso; A Reunanen; T Klaukka; Arpo Aromaa; J Maatela; Kalevi Pyörälä
Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987.
American journal of epidemiology 1991;133(9):850-7.
1991: H Sarlund; Markku Laakso; E Voutilainen; I Penttilä; Kalevi Pyörälä
Familial aggregation of non-insulin dependent diabetes and coronary heart disease are accompanied by different effects on serum lipids, lipoproteins and apolipoproteins.
Atherosclerosis 1991;86(1):17-29.
1991: Jyrki T Kuikka; J N Mustonen; M I J Uusitupa; Pentti J Rautio; Esko Vanninen; Markku Laakso; Esko Länsimies; Kalevi Pyörälä
Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid.
European journal of nuclear medicine 1991;18(7):475-81.
1990: Leena Mykkänen; Markku Laakso; Matti Uusitupa; Kalevi Pyörälä
Prevalence of diabetes and impaired glucose tolerance in elderly subjects and their association with obesity and family history of diabetes.
Diabetes care 1990;13(11):1099-105.
1990: M I J Uusitupa; Markku Laakso; H Sarlund; H Majander; Jukka Takala; I Penttilä
Effects of a very-low-calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics.
The American journal of clinical nutrition 1990;51(5):768-73.
1990: Markku Laakso; Kalevi Pyörälä
Plasma lipids and lipoproteins in diabetes: lessons from population-based studies.
The Journal of diabetic complications 1990;4(2):39-41.
1990: Markku Laakso; M Suhonen; Risto Julkunen; Kalevi Pyörälä
Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study.
Gut 1990;31(3):344-7.
1990: Markku Laakso; H Sarlund; L Mykkänen
Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance.
Arteriosclerosis (Dallas, Tex.) 1990;10(2):223-31.
1990: Markku Laakso; Kalevi Pyörälä
Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes.
Metabolism: clinical and experimental 1990;39(2):117-22.
1989: Markku Laakso; H Sarlund; L Mykkänen
Essential hypertension and insulin resistance in non-insulin-dependent diabetes.
European journal of clinical investigation 1989;19(6):518-26.
1989: Markku Laakso; T Rönnemaa; H Sarlund; Kalevi Pyörälä; V Kallio
Factors associated with fasting and postglucagon plasma C-peptide levels in middle-aged insulin-treated diabetic patients.
Diabetes care 1989;12(2):83-8.
1989: Matti Uusitupa; Markku Laakso; H Sarlund; H Majander; Jukka Takala; I Penttilä
Long term effects of a very low calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics.
International journal of obesity 1989;13 Suppl 2():163-4.
1988: J N Mustonen; M I J Uusitupa; Kari U O Tahvanainen; S Talwar; Markku Laakso; Esko Länsimies; Jyrki T Kuikka; Kalevi Pyörälä
Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease.
The American journal of cardiology 1988;62(17):1273-9.
1988: Matti Uusitupa; J Mustonen; Markku Laakso; P Vainio; Esko Länsimies; S Talwar; Kalevi Pyörälä
Impairment of diastolic function in middle-aged type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease.
Diabetologia 1988;31(11):783-91.
1988: Markku Laakso; Kalevi Pyörälä
Lipid and lipoprotein abnormalities in diabetic patients with peripheral vascular disease.
Atherosclerosis 1988;74(1-2):55-63.
1988: Markku Laakso; Matti Uusitupa; Jukka Takala; H Majander; T Reijonen; I Penttilä
Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects.
Metabolism: clinical and experimental 1988;37(11):1092-100.
1988: J Mustonen; Markku Laakso; Matti Uusitupa; H Sarlund; Kalevi Pyörälä; Pentti J Rautio; Jyrki Kuikka; Esko Länsimies
Improvement of left ventricular function after starting insulin treatment in patients with non-insulin-dependent diabetes.
Diabetes research (Edinburgh, Scotland) 1988;9(1):27-30.
1988: Markku Laakso; T Rönnemaa; Kalevi Pyörälä; V Kallio; P Puukka; I Penttilä
Atherosclerotic vascular disease and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects in Finland.
Diabetes care 1988;11(6):449-63.
1988: K J Reinikainen; Leo Paljärvi; M Huuskonen; Hilkka Soininen; Markku Laakso; PJ Riekkinen
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease.
Journal of the neurological sciences 1988;84(1):101-16.
1988: K J Reinikainen; PJ Riekkinen; Leo Paljärvi; Hilkka Soininen; Eeva-Liisa Helkala; Jukka Jolkkonen; Markku Laakso
Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data.
Neurochemical research 1988;13(2):135-46.
1988: Markku Laakso; H Sarlund; T Korhonen; E Voutilainen; H Majander; P Hakala; Matti Uusitupa; Kalevi Pyörälä
Stopping insulin treatment in middle-aged diabetic patients with high postglucagon plasma C-peptide. Effect on glycaemic control, serum lipids and lipoproteins.
Acta medica Scandinavica 1988;223(1):61-8.
1987: Markku Laakso; H Sarlund; C Ehnholm; E Voutilainen; A Aro; Kalevi Pyörälä
Relationship between postheparin plasma lipases and high-density lipoprotein cholesterol in different types of diabetes.
Diabetologia 1987;30(9):703-6.
1984: Markku Laakso; M Suhonen; M Helin
[Mediastinal lipomatosis simulating cardiomegaly].
Duodecim; lääketieteellinen aikakauskirja 1984;100(2):96-9.