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Markku Laakso

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Disorders

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Finland

Chemicals & Drugs

Genes & Molecular Sequences

Devices

Glucose Clamp Technique

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Publications

TOP 3
Meex Steven J R; Weissglas-Volkov Daphna; van der Kallen Carla J H; Thuerauf Donna J; van Greevenbroek Marleen M J; Schalkwijk Casper G; Stehouwer Coen D A; Feskens Edith J M; Heldens Lonneke; Ayoubi Torik A; Hofker Marten H; Wouters Bradly G; Vlietinck Robert; Sinsheimer Janet S; Taskinen Marja-Riitta; Kuusisto Johanna; Laakso Markku; de Bruin Tjerk W A; Pajukanta Päivi; Glembotski Christopher C
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Stancáková Alena; Kuulasmaa Teemu; Paananen Jussi; Jackson Anne U; Bonnycastle Lori L; Collins Francis S; Boehnke Michael; Kuusisto Johanna; Laakso Markku
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
Lappalainen Saila; Voutilainen Raimo; Utriainen Pauliina; Laakso Markku; Jääskeläinen Jarmo
Genetic variation of FTO and TCF7L2 in premature adrenarche.

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All Publications

2009: Meex Steven J R; Weissglas-Volkov Daphna; van der Kallen Carla J H; Thuerauf Donna J; van Greevenbroek Marleen M J; Schalkwijk Casper G; Stehouwer Coen D A; Feskens Edith J M; Heldens Lonneke; Ayoubi Torik A; Hofker Marten H; Wouters Bradly G; Vlietinck Robert; Sinsheimer Janet S; Taskinen Marja-Riitta; Kuusisto Johanna; Laakso Markku; de Bruin Tjerk W A; Pajukanta Päivi; Glembotski Christopher C
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1322-7.
2009: Stancáková Alena; Kuulasmaa Teemu; Paananen Jussi; Jackson Anne U; Bonnycastle Lori L; Collins Francis S; Boehnke Michael; Kuusisto Johanna; Laakso Markku
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
Diabetes 2009;58(9):2129-36.
2009: Lappalainen Saila; Voutilainen Raimo; Utriainen Pauliina; Laakso Markku; Jääskeläinen Jarmo
Genetic variation of FTO and TCF7L2 in premature adrenarche.
Metabolism: clinical and experimental 2009;58(9):1263-9.
2009: Koutnikova Hana; Laakso Markku; Lu Lu; Combe Roy; Paananen Jussi; Kuulasmaa Teemu; Kuusisto Johanna; Häring Hans-Ulrich; Hansen Torben; Pedersen Oluf; Smith Ulf; Hanefeld Markolf; Williams Robert W; Auwerx Johan
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
PLoS genetics 2009;5(8):e1000591.
2009: Kilhovd Bente K; Juutilainen Auni; Lehto Seppo; Rönnemaa Tapani; Torjesen Peter A; Hanssen Kristian F; Laakso Markku
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women.
Atherosclerosis 2009;205(2):590-4.
2009: Gylling Helena; Hallikainen Maarit; Raitakari Olli T; Laakso Markku; Vartiainen Erkki; Salo Pia; Korpelainen Vesa; Sundvall Jouko; Miettinen Tatu A
Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation.
The British journal of nutrition 2009;101(11):1688-95.
2009: Stancáková Alena; Javorský Martin; Kuulasmaa Teemu; Haffner Steven M; Kuusisto Johanna; Laakso Markku
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men.
Diabetes 2009;58(5):1212-21.
2009: Honka Miikka-Juhani; Vänttinen Markku; Iozzo Patricia; Virtanen Kirsi A; Lautamäki Riikka; Hällsten Kirsti; Borra Ronald J H; Takala Teemu; Viljanen Antti P M; Kemppainen Jukka; Pihlajamäki Jussi; Knuuti Juhani; Nuutila Pirjo; Laakso Markku
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2009;58(4):541-6.
2009: Lappalainen Tiina J; Tolppanen Anna-Maija; Kolehmainen Marjukka; Schwab Ursula; Lindström Jaana; Tuomilehto Jaakko; Pulkkinen Leena; Eriksson Johan G; Laakso Markku; Gylling Helena; Uusitupa Matti;
The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.
Obesity (Silver Spring, Md.) 2009;17(4):832-6.
2009: Gylling Helena; Hallikainen Maarit; Rajaratnam Radhakrishnan A; Simonen Piia; Pihlajamäki Jussi; Laakso Markku; Miettinen Tatu A
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.
Metabolism: clinical and experimental 2009;58(3):401-7.
2009: Laakso M
Not for the eyes only: PAX6 and glucose metabolism.
Diabetologia 2009;52(3):381-4.
2009: Heikkinen Sami; Argmann Carmen; Feige Jérôme N; Koutnikova Hana; Champy Marie-France; Dali-Youcef Nassim; Schadt Eric E; Laakso Markku; Auwerx Johan
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.
Cell metabolism 2009;9(1):88-98.
2009: Salopuro Titta; Pulkkinen Leena; Lindström Jaana; Kolehmainen Marjukka; Tolppanen Anna-Maija; Eriksson Johan G; Valle Timo T; Aunola Sirkka; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaakko; Laakso Markku; Uusitupa Matti
Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
BMC medical genetics 2009;10():94.
2009: Ahonen Tiina; Saltevo Juha; Laakso Markku; Kautiainen Hannu; Kumpusalo Esko; Vanhala Mauno
Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure.
Mediators of inflammation 2009;2009():959281.
2009: Weyrich Peter; Staiger Harald; Stancáková Alena; Schäfer Silke A; Kirchhoff Kerstin; Ullrich Susanne; Ranta Felicia; Gallwitz Baptist; Stefan Norbert; Machicao Fausto; Kuusisto Johanna; Laakso Markku; Fritsche Andreas; Häring Hans-Ulrich
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
BMC medical genetics 2009;10():77.
2008: Laakso Markku
Diabetes as a 'cardiovascular disease equivalent': implications for treatment.
Nature clinical practice. Cardiovascular medicine 2008;5(11):682-3.
2008: Ungaro Paola; Teperino Raffaele; Mirra Paola; Cassese Angela; Fiory Francesca; Perruolo Giuseppe; Miele Claudia; Laakso Markku; Formisano Pietro; Beguinot Francesco
Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.
The Journal of biological chemistry 2008;283(45):30970-9.
2008: Koikkalainen Juha R; Antila Margareta; Lötjönen Jyrki M P; Heliö Tiina; Lauerma Kirsi; Kivistö Sari M; Sipola Petri; Kaartinen Maija A; Kärkkäinen Satu T J; Reissell Eeva; Kuusisto Johanna; Laakso Markku; Oresic Matej; Nieminen Markku S; Peuhkurinen Keijo J
Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data.
Radiology 2008;249(1):88-96.
2008: Bakris George; Böhm Michael; Dagenais Gilles; Diener Hans-Christoph; Fujita Toshiro; Gorelick Philip; Kjeldsen Sverre Erik; Laakso Markku; Mancia Giuseppe; Pitt Bertram; Sharma Arya; Sleight Peter; Teo Koon; Unger Thomas; Weber Michael; Williams Bryan; Zannad Faiez
Cardiovascular protection for all individuals at high risk: evidence-based best practice.
Clinical research in cardiology : official journal of the German Cardiac Society 2008;97(10):713-25.
2008: Balkau Beverley; Mhamdi Leila; Oppert Jean-Michel; Nolan John; Golay Alain; Porcellati Francesca; Laakso Markku; Ferrannini Ele;
Physical activity and insulin sensitivity: the RISC study.
Diabetes 2008;57(10):2613-8.
2008: Lee Jenny C; Weissglas-Volkov Daphna; Kyttälä Mira; Dastani Zari; Cantor Rita M; Sobel Eric M; Plaisier Christopher L; Engert James C; van Greevenbroek Marleen M J; Kane John P; Malloy Mary J; Pullinger Clive R; Huertas-Vazquez Adriana; Aguilar-Salinas Carlos A; Tusie-Luna Teresa; de Bruin Tjerk W A; Aouizerat Bradley E; van der Kallen Carla C J; Croce Carlo M; Aqeilan Rami I; Marcil Michel; Viikari Jorma S A; Lehtimäki Terho; Raitakari Olli T; Kuusisto Johanna; Laakso Markku; Taskinen Marja-Riitta; Genest Jacques; Pajukanta Päivi
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
American journal of human genetics 2008;83(2):180-92.
2008: Saltevo J; Laakso M; Jokelainen J; Keinänen-Kiukaanniemi S; Kumpusalo E; Vanhala M
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study.
Diabetes/metabolism research and reviews 2008;24(5):378-83.
2008: Saltevo J; Vanhala M; Kautiainen H; Kumpusalo E; Laakso M
Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(6):747-50.
2008: Boesgaard T W; Zilinskaite J; Vänttinen M; Laakso M; Jansson P-A; Hammarstedt A; Smith U; Stefan N; Fritsche A; Häring H; Hribal M; Sesti G; Zobel D P; Pedersen O; Hansen T;
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.
Diabetologia 2008;51(5):816-20.
2008: Stancáková Alena; Pihlajamäki Jussi; Kuusisto Johanna; Stefan Norbert; Fritsche Andreas; Häring Hans; Andreozzi Francesco; Succurro Elena; Sesti Giorgio; Boesgaard Trine Welløv; Hansen Torben; Pedersen Oluf; Jansson Per Anders; Hammarstedt Ann; Smith Ulf; Laakso Markku;
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
The Journal of clinical endocrinology and metabolism 2008;93(5):1924-30.
2008: Liu Xiao-Qing; Paterson Andrew D; He Ning; St George-Hyslop Peter; Rauta Virpi; Gronhagen-Riska Carola; Laakso Markku; Thibaudin Lise; Berthoux Francois; Cattran Daniel; Pei York
IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.
Journal of the American Society of Nephrology : JASN 2008;19(5):1025-33.
2008: Laitinen Tomi; Lyyra-Laitinen Tiina; Huopio Hanna; Vauhkonen Ilkka; Halonen Toivo; Hartikainen Juha; Niskanen Leo; Laakso Markku
Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2008;13(2):97-105.
2008: Miettinen Kati H; Lassus Johan; Harjola Veli-Pekka; Siirilä-Waris Krista; Melin John; Punnonen Kari R; Nieminen Markku S; Laakso Markku; Peuhkurinen Keijo J
Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2008;10(4):396-403.
2008: Wang Jianjun; Ruotsalainen Sanna; Moilanen Leena; Lepistö Päivi; Laakso Markku; Kuusisto Johanna
The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.
Stroke; a journal of cerebral circulation 2008;39(4):1078-83.
2008: Thamer Claus; Machann Jürgen; Stefan Norbert; Schäfer Silke A; Machicao Fausto; Staiger Harald; Laakso Markku; Böttcher Michael; Claussen Claus; Schick Fritz; Fritsche Andreas; Haring Hans-Ulrich
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study.
The Journal of clinical endocrinology and metabolism 2008;93(4):1497-500.
2008: Juutilainen Auni; Lehto Seppo; Rönnemaa Tapani; Pyörälä Kalevi; Laakso Markku
Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects.
Diabetes care 2008;31(4):714-9.
2008: Kilpeläinen Tuomas O; Lakka Timo A; Laaksonen David E; Mager Ursula; Salopuro Titta; Kubaszek Agata; Todorova Boryana; Laukkanen Olli; Lindström Jaana; Eriksson Johan G; Hämäläinen Helena; Aunola Sirkka; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaako; Laakso Markku; Uusitupa Matti;
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.
Metabolism: clinical and experimental 2008;57(3):428-36.
2008: Laakso M; Zilinskaite J; Hansen T; Boesgaard T Welløv; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst J J; Kuulasmaa T; Hribal M L; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U;
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Diabetologia 2008;51(3):502-11.
2008: Ruotsalainen Eija; Vauhkonen Ilkka; Salmenniemi Urpu; Pihlajamäki Jussi; Punnonen Kari; Kainulainen Sakari; Jalkanen Sirpa; Salmi Marko; Laakso Markku
Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects.
Atherosclerosis 2008;197(1):271-7.
2008: Lindi Virpi; Schwab Ursula; Louheranta Anne; Vessby Bengt; Hermansen Kjeld; Tapsell Linda; Riccardi Gabriele; Rivellese Angela A; Laakso Markku; Uusitupa Matti I J;
The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(2):88-95.
2008: Kilpeläinen Tuomas O; Lakka Timo A; Laaksonen David E; Lindström Jaana; Eriksson Johan G; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Lindi Virpi; Tuomilehto Jaakko; Uusitupa Matti; Laakso Markku
SNPs in PPARG associate with type 2 diabetes and interact with physical activity.
Medicine and science in sports and exercise 2008;40(1):25-33.
2008: Friedrich Björn; Weyrich Peter; Stancáková Alena; Wang Jianjung; Kuusisto Johanna; Laakso Markku; Sesti Giorgio; Succurro Elena; Smith Ulf; Hansen Torben; Pedersen Oluf; Machicao Fausto; Schäfer Silke; Lang Florian; Risler Teut; Ullrich Susanne; Stefan Norbert; Fritsche Andreas; Häring Hans-Ulrich
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.
PloS one 2008;3(11):e3506.
2007: Rutanen Jarno; Pihlajamäki Jussi; Vänttinen Markku; Salmenniemi Urpu; Ruotsalainen Eija; Kuulasmaa Teemu; Kainulainen Sakari; Kuusisto Johanna; Laakso Markku
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.
Obesity (Silver Spring, Md.) 2007;15(12):2902-7.
2007: Saltevo Juha; Vanhala Mauno; Kautiainen Hannu; Laakso Markku
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(4):328-31.
2007: Wang Jianjun; Ruotsalainen Sanna; Moilanen Leena; Lepistö Päivi; Laakso Markku; Kuusisto Johanna
Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns.
Diabetes care 2007;30(12):3099-104.
2007: Heinonen Suvi E; Leppänen Pia; Kholová Ivana; Lumivuori Henri; Häkkinen Sanna-Kaisa; Bosch Fatima; Laakso Markku; Ylä-Herttuala Seppo
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia.
Circulation research 2007;101(10):1058-67.
2007: Kuusisto Johanna; Andrulionyte Laura; Laakso Markku
Atherosclerosis and cardiovascular risk reduction with PPAR agonists.
Current atherosclerosis reports 2007;9(4):274-80.
2007: Kilpeläinen T O; Lakka T A; Laaksonen D E; Laukkanen O; Lindström J; Eriksson J G; Valle T T; Hämäläinen H; Aunola S; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Uusitupa M; Laakso M;
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes.
Physiological genomics 2007;31(2):264-72.
2007: Sittiwet Chaiyasit; Gylling Helena; Hallikainen Maarit; Pihlajamäki Jussi; Moilanen Leena; Laaksonen David E; Niskanen Leo; Agren Jyrki J; Laakso Markku; Miettinen Tatu A
Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control.
Atherosclerosis 2007;194(2):465-72.
2007: Pirinen Eija; Kuulasmaa Teemu; Pietilä Marko; Heikkinen Sami; Tusa Maija; Itkonen Paula; Boman Susanna; Skommer Joanna; Virkamäki Antti; Hohtola Esa; Kettunen Mikko; Fatrai Szabolcs; Kansanen Emilia; Koota Suvi; Niiranen Kirsi; Parkkinen Jyrki; Levonen Anna-Liisa; Ylä-Herttuala Seppo; Hiltunen J Kalervo; Alhonen Leena; Smith Ulf; Jänne Juhani; Laakso Markku
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Kilhovd B K; Juutilainen A; Lehto S; Rönnemaa T; Torjesen P A; Hanssen K F; Laakso M
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study.
Diabetologia 2007;50(7):1409-17.
2007: Gylling Helena; Hallikainen Maarit; Kolehmainen Marjukka; Toppinen Leena; Pihlajamäki Jussi; Mykkänen Hannu; Agren Jyrki J; Rauramaa Rainer; Laakso Markku; Miettinen Tatu A
Cholesterol synthesis prevails over absorption in metabolic syndrome.
Translational research : the journal of laboratory and clinical medicine 2007;149(6):310-6.
2007: Wang J; Kuusisto J; Vänttinen M; Kuulasmaa T; Lindström J; Tuomilehto J; Uusitupa M; Laakso M
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.
Diabetologia 2007;50(6):1192-200.
2007: Tuunanen Helena; Kuusisto Johanna; Toikka Jyri; Jääskeläinen Pertti; Marjamäki Päivi; Peuhkurinen Keijo; Viljanen Tapio; Sipola Petri; Stolen Kira Q; Hannukainen Jarna; Nuutila Pirjo; Laakso Markku; Knuuti Juhani
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3):354-65.
2007: Andrulionyte Laura; Kuulasmaa Teemu; Chiasson Jean-Louis; Laakso Markku;
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2007;56(4):1181-6.
2007: Wang Jianjun; Ruotsalainen Sanna; Moilanen Leena; Lepistö Päivi; Laakso Markku; Kuusisto Johanna
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.
European heart journal 2007;28(7):857-64.
2007: Soinio Minna; Marniemi Jukka; Laakso Markku; Pyörälä Kalevi; Lehto Seppo; Rönnemaa Tapani
Serum zinc level and coronary heart disease events in patients with type 2 diabetes.
Diabetes care 2007;30(3):523-8.
2007: Rutanen Jarno; Pihlajamäki Jussi; Vänttinen Markku; Salmenniemi Urpu; Ruotsalainen Eija; Kuulasmaa Teemu; Kainulainen Sakari; Laakso Markku
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism 2007;92(3):1112-7.
2007: Juutilainen Auni; Lehto Seppo; Rönnemaa Tapani; Pyörälä Kalevi; Laakso Markku
Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women.
Diabetes care 2007;30(2):292-9.
2007: Saltevo Juha; Vanhala Mauno; Kautiainen Hannu; Kumpusalo Esko; Laakso Markku
Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome.
Mediators of inflammation 2007;2007():93573.
2007: Laakso Markku; Uusitupa Matti
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(12):1439-47.
2007: Laakso Markku; Groop Leif
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(12):1427-9.
2006: Ruotsalainen Eija; Salmenniemi Urpu; Vauhkonen Ilkka; Pihlajamäki Jussi; Punnonen Kari; Kainulainen Sakari; Laakso Markku
Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.
Diabetes care 2006;29(12):2714-20.
2006: Karinen Hannele; Kärkkäinen Päivi; Pihlajamäki Jussi; Janatuinen Esko; Heikkinen Markku; Julkunen Risto; Kosma Veli-Matti; Naukkarinen Anita; Laakso Markku
HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease.
Scandinavian journal of gastroenterology 2006;41(11):1299-304.
2006: Mousavinasab Firoozeh; Tähtinen Tuula; Jokelainen Jari; Koskela Pentti; Vanhala Mauno; Oikarinen Jorma; Laakso Markku; Keinänen-Kiukaanniemi Sirkka
The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.
Endocrine 2006;30(2):185-90.
2006: Niiranen Kirsi; Keinänen Tuomo A; Pirinen Eija; Heikkinen Sami; Tusa Maija; Fatrai Szabolcs; Suppola Suvikki; Pietilä Marko; Uimari Anne; Laakso Markku; Alhonen Leena; Jänne Juhani
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Roy Himadri; Bhardwaj Shalini; Babu Mohan; Kokina Ilze; Uotila Sanna; Ahtialansaari Tiia; Laitinen Teemu; Hakumaki Juhana; Laakso Markku; Herzig Karl-Heinz; Ylä-Herttuala Seppo
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2159-61.
2006: Vanhanen M; Koivisto K; Moilanen L; Helkala E L; Hänninen T; Soininen H; Kervinen K; Kesäniemi Y A; Laakso M; Kuusisto J
Association of metabolic syndrome with Alzheimer disease: a population-based study.
Neurology 2006;67(5):843-7.
2006: Sipola P; Peuhkurinen K; Lauerma K; Husso M; Jääskeläinen P; Laakso M; Aronen H J; Risteli J; Kuusisto J
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: magnetic resonance imaging study.
Heart (British Cardiac Society) 2006;92(9):1321-2.
2006: Saarela Tanja; Hiltunen Mikko; Helisalmi Seppo; Heinonen Seppo; Laakso Markku
Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia.
European journal of obstetrics, gynecology, and reproductive biology 2006;128(1-2):175-9.
2006: Andrulionyte Laura; Laukkanen Olli; Chiasson Jean-Louis; Laakso Markku;
Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.
Journal of molecular medicine (Berlin, Germany) 2006;84(8):701-8.
2006: Siitonen N; Pulkkinen L; Mager U; Lindström J; Eriksson J G; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Laakso M; Uusitupa M
Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.
Diabetologia 2006;49(8):1795-805.
2006: Peltola Paula; Pihlajamäki Jussi; Koutnikova Hana; Ruotsalainen Eija; Salmenniemi Urpu; Vauhkonen Ilkka; Kainulainen Sakari; Gylling Helena; Miettinen Tatu A; Auwerx Johan; Laakso Markku
Visceral obesity is associated with high levels of serum squalene.
Obesity (Silver Spring, Md.) 2006;14(7):1155-63.
2006: Andrulionyte Laura; Peltola Paula; Chiasson Jean-Louis; Laakso Markku;
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2006;55(7):2148-52.
2006: Pihlajamäki J; Salmenniemi U; Vänttinen M; Ruotsalainen E; Kuusisto J; Vauhkonen I; Kainulainen S; Ng M C Y; Cox N J; Bell G I; Laakso M
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.
Diabetologia 2006;49(7):1560-6.
2006: Mager U; Lindi V; Lindström J; Eriksson J G; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Laakso M; Pulkkinen L; Uusitupa M;
Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(6):685-9.
2006: Kärkkäinen S; Reissell E; Heliö T; Kaartinen M; Tuomainen P; Toivonen L; Kuusisto J; Kupari M; Nieminen M S; Laakso M; Peuhkurinen K
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy.
Heart (British Cardiac Society) 2006;92(4):524-6.
2006: Poutanen Tuija; Tikanoja Tero; Jääskeläinen Pertti; Jokinen Eero; Silvast Annuli; Laakso Markku; Kuusisto Johanna
Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes.
American heart journal 2006;151(3):725.e1-725.e9.
2006: Karinen Hannele; Kärkkäinen Päivi; Pihlajamäki Jussi; Janatuinen Esko; Heikkinen Markku; Julkunen Risto; Kosma Veli-Matti; Naukkarinen Anita; Laakso Markku
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.
Scandinavian journal of gastroenterology 2006;41(2):191-9.
2006: Soinio Minna; Marniemi Jukka; Laakso Markku; Lehto Seppo; Rönnemaa Tapani
High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study.
Diabetes care 2006;29(2):329-33.
2006: Mousavinasab Firoozeh; Tähtinen Tuula; Jokelainen Jari; Koskela Pentti; Vanhala Mauno; Oikarinen Jorma; Keinänen-Kiukaanniemi Sirkka; Laakso Markku
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.
Molecular genetics and metabolism 2006;87(2):147-51.
2006: Otonkoski Timo; Näntö-Salonen Kirsti; Seppänen Marko; Veijola Riitta; Huopio Hanna; Hussain Khalid; Tapanainen Päivi; Eskola Olli; Parkkola Riitta; Ekström Klas; Guiot Yves; Rahier Jacques; Laakso Markku; Rintala Risto; Nuutila Pirjo; Minn Heikki
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.
Diabetes 2006;55(1):13-8.
2006: Juutilainen A; Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women.
Diabetologia 2006;49(1):56-65.
2006: González-Sánchez José L; Martínez-Calatrava María J; Martínez-Larrad María T; Zabena Carina; Fernández-Pérez Cristina; Laakso Markku; Serrano-Ríos Manuel
Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population.
Clinical chemistry 2006;52(1):97-103.
2006: Laakso Markku
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2006;122(13):1563-4.
2006: Koivisto Anne M; Helisalmi Seppo; Pihlajamaki Jussi; Hiltunen Mikko; Koivisto Keijo; Moilanen Leena; Kuusisto Johanna; Helkala Eeva-Liisa; Hanninen Tuomo; Kervinen Kari; Kesaniemi Y Antero; Laakso Markku; Soininen Hilkka
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.
Dementia and geriatric cognitive disorders 2006;22(5-6):449-53.
2006: Saarela Tanja; Hiltunen Mikko; Helisalmi Seppo; Heinonen Seppo; Laakso Markku
Adiponectin gene haplotype is associated with preeclampsia.
Genetic testing 2006;10(1):35-9.
2006: Lumiaho Anne; Laakso Markku
[Autosomal dominant polycystic kidney disease]
Duodecim; lääketieteellinen aikakauskirja 2006;122(2):200-7.
2006: Laakso Markku; Kovanen Petri T
Metabolic syndrome: to be or not to be?
Annals of medicine 2006;38(1):32-3.
2006: Saarela Tanja; Hiltunen Mikko; Helisalmi Seppo; Heinonen Seppo; Laakso Markku
Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia.
Gynecologic and obstetric investigation 2006;61(3):124-7.
2005: Juutilainen Auni; Lehto Seppo; Rönnemaa Tapani; Pyörälä Kalevi; Laakso Markku
Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects.
Diabetes care 2005;28(12):2901-7.
2005: Vänttinen Markku; Nuutila Pirjo; Kuulasmaa Teemu; Pihlajamäki Jussi; Hällsten Kirsti; Virtanen Kirsi A; Lautamäki Riikka; Peltoniemi Pauliina; Takala Teemu; Viljanen Antti P M; Knuuti Juhani; Laakso Markku
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake.
Diabetes 2005;54(12):3587-91.
2005: Luoma Jukka S; Kareinen Anu; Närvänen Outi; Viitanen Laura; Laakso Markku; Ylä-Herttuala Seppo
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
Free radical biology & medicine 2005;39(12):1660-5.
2005: Salmenniemi U; Ruotsalainen E; Vänttinen M; Vauhkonen I; Pihlajamäki J; Kainulainen S; Punnonen K; Laakso M
High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients.
International journal of obesity (2005) 2005;29(12):1464-70.
2005: Salopuro T; Pulkkinen L; Lindström J; Eriksson J G; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Laakso M; Uusitupa M;
Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study.
International journal of obesity (2005) 2005;29(10):1245-51.
2005: Sipola Petri; Lauerma Kirsi; Jääskeläinen Pertti; Laakso Markku; Peuhkurinen Keijo; Manninen Hannu; Aronen Hannu J; Kuusisto Johanna
Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene.
Radiology 2005;236(3):815-24.
2005: Pätäri A; Karhapää P; Taipale H; Salmenniemi U; Ruotsalainen E; Vanninen P; Holthöfer H; Laakso M
A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients.
Diabetologia 2005;48(9):1844-50.
2005: Mousavinasab Firoozeh; Tähtinen Tuula; Jokelainen Jari; Koskela Pentti; Vanhala Mauno; Oikarinen Jorma; Keinänen-Kiukaanniemi Sirkka; Laakso Markku
Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.
Endocrine 2005;27(3):307-9.
2005: Vauhkonen Ilkka; Niskanen Leo; Knip Mikael; Mykkänen Leena Moilanen; Haffner Steven; Uusitupa Matti; Laakso Markku
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):265-73.
2005: Peltola Paula; Lumiaho Anne; Miettinen Raija; Pihlajamäki Jussi; Sandford Richard; Laakso Markku
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns.
Journal of molecular medicine (Berlin, Germany) 2005;83(8):638-46.
2005: Koivisto Anne M; Helisalmi Seppo; Pihlajamäki Jussi; Moilanen Leena; Kuusisto Johanna; Laakso Markku; Hiltunen Mikko; Keijo Koivisto; Hänninen Tuomo; Helkala Eeva-Liisa; Kervinen Kari; Kesäniemi Y Antero; Soininen Hilkka
Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Journal of neurogenetics 2005;19(3-4):155-61.
2005: Laukkanen Olli; Lindström Jaana; Eriksson Johan; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaakko; Uusitupa Matti; Laakso Markku;
Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Diabetes 2005;54(7):2256-60.
2005: Pihlajamäki J; Kinnunen M; Ruotsalainen E; Salmenniemi U; Vauhkonen I; Kuulasmaa T; Kainulainen S; Laakso M
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.
Diabetologia 2005;48(7):1331-4.
2005: Salmenniemi Urpu; Zacharova Jelena; Ruotsalainen Eija; Vauhkonen Ilkka; Pihlajamäki Jussi; Kainulainen Sakari; Punnonen Kari; Laakso Markku
Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2005;90(7):4216-23.
2005: Vänttinen Markku; Nuutila Pirjo; Pihlajamäki Jussi; Hällsten Kirsti; Virtanen Kirsi A; Lautamäki Riikka; Peltoniemi Pauliina; Kemppainen Jukka; Takala Teemu; Viljanen Antti P M; Knuuti Juhani; Laakso Markku
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study.
The Journal of clinical endocrinology and metabolism 2005;90(7):4249-54.
2005: Saarela Tanja; Hiltunen Mikko; Helisalmi Seppo; Heinonen Seppo; Laakso Markku
Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia.
Molecular human reproduction 2005;11(6):437-40.
2005: González-Sánchez José L; Zabena Carina A; Martínez-Larrad María T; Fernández-Pérez Cristina; Pérez-Barba Milagros; Laakso Markku; Serrano-Ríos Manuel
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance.
Obesity research 2005;13(5):807-12.
2005: Laakso M
Prevention of type 2 diabetes.
Current molecular medicine 2005;5(3):365-74.
2005: Mousavinasab Firoozeh; Tähtinen Tuula; Jokelainen Jari; Koskela Pentti; Vanhala Mauno; Oikarinen Jorma; Keinänen-Kiukaanniemi Sirkka; Laakso Markku
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
Molecular genetics and metabolism 2005;84(4):344-8.
2005: Kilhovd Bente K; Juutilainen Auni; Lehto Seppo; Rönnemaa Tapani; Torjesen Peter A; Birkeland Kåre I; Berg Tore J; Hanssen Kristian F; Laakso Markku
High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):815-20.
2005: Zacharova Jelena; Chiasson Jean-Louis; Laakso Markku
Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance.
Obesity research 2005;13(3):501-6.
2005: Zacharova Jelena; Chiasson Jean-Louis; Laakso Markku;
The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Diabetes 2005;54(3):893-9.
2005: Zacharova J; Todorova B R; Chiasson J-L; Laakso M;
The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
Journal of internal medicine 2005;257(2):185-93.
2005: Rajala U; Laakso M; Päivänsalo M; Suramo I; Keinänen-Kiukaanniemi S
Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance.
Journal of human hypertension 2005;19(1):85-91.
2005: Laakso Markku
[New criteria and care for metabolic syndrome]
Duodecim; lääketieteellinen aikakauskirja 2005;121(14):1521-30.
2005: Huopio Hanna; Laakso Markku; Otonkoski Timo
[Congenital hyperinsulinism]
Duodecim; lääketieteellinen aikakauskirja 2005;121(11):1166-75.
2004: Salmenniemi Urpu; Ruotsalainen Eija; Pihlajamäki Jussi; Vauhkonen Ilkka; Kainulainen Sakari; Punnonen Kari; Vanninen Esko; Laakso Markku
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome.
Circulation 2004;110(25):3842-8.
2004: Andrulionytè L; Zacharova J; Chiasson J-L; Laakso M;
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
Diabetologia 2004;47(12):2176-84.
2004: Laukkanen Olli; Pihlajamäki Jussi; Lindström Jaana; Eriksson Johan; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaakko; Uusitupa Matti; Laakso Markku;
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.
The Journal of clinical endocrinology and metabolism 2004;89(12):6286-90.
2004: Sivenius K; Niskanen L; Voutilainen-Kaunisto R; Laakso M; Uusitupa M
Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1325-33.
2004: Juutilainen Auni; Kortelainen Saara; Lehto Seppo; Rönnemaa Tapani; Pyörälä Kalevi; Laakso Markku
Gender difference in the impact of type 2 diabetes on coronary heart disease risk.
Diabetes care 2004;27(12):2898-904.
2004: Kärkkäinen Satu; Heliö Tiina; Jääskeläinen Pertti; Miettinen Raija; Tuomainen Petri; Ylitalo Kari; Kaartinen Maija; Reissell Eeva; Toivonen Lauri; Nieminen Markku S; Kuusisto Johanna; Laakso Markku; Peuhkurinen Keijo
Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2004;6(7):861-8.
2004: Rioux John D; Karinen Hannele; Kocher Kerry; McMahon Sheila Guschwan; Kärkkäinen Päivi; Janatuinen Esko; Heikkinen Markku; Julkunen Risto; Pihlajamäki Jussi; Naukkarinen Anita; Kosma Veli-Matti; Daly Mark J; Lander Eric S; Laakso Markku
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
American journal of medical genetics. Part A 2004;130A(4):345-50.
2004: Salopuro T; Lindström J; Eriksson J G; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Laakso M; Uusitupa M
Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study.
Clinical genetics 2004;66(4):365-7.
2004: Temelkova-Kurktschiev Theodora; Hanefeld Markolf; Chinetti Giulia; Zawadzki Christophe; Haulon Stephan; Kubaszek Agata; Koehler Carsta; Leonhardt Wolfgang; Staels Bart; Laakso Markku
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
The Journal of clinical endocrinology and metabolism 2004;89(9):4238-42.
2004: Gylling Helena; Hallikainen Maarit; Pihlajamäki Jussi; Agren Jyrki; Laakso Markku; Rajaratnam Radhakrishnan A; Rauramaa Rainer; Miettinen Tatu A
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity.
Journal of lipid research 2004;45(9):1660-5.
2004: Siitonen N; Lindström J; Eriksson J; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Laakso M; Uusitupa M
Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.
Diabetologia 2004;47(8):1416-24.
2004: Sivenius Katariina; Pihlajamäki Jussi; Partanen Juhani; Niskanen Leo; Laakso Markku; Uusitupa Matti
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes.
Diabetes care 2004;27(8):2021-6.
2004: Cuesta-Muñoz Antonio L; Huopio Hanna; Otonkoski Timo; Gomez-Zumaquero Juan M; Näntö-Salonen Kirsti; Rahier Jacques; López-Enriquez Soledad; García-Gimeno Maria A; Sanz Pascual; Soriguer Federico C; Laakso Markku
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Diabetes 2004;53(8):2164-8.
2004: Rutanen Jarno; Pihlajamäki Jussi; Karhapää Pauli; Vauhkonen Ilkka; Kuusisto Johanna; Moilanen Mykkänen Leena; Laakso Markku
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.
Obesity research 2004;12(7):1060-6.
2004: Kärkkäinen Satu; Heliö Tiina; Miettinen Raija; Tuomainen Petri; Peltola Paula; Rummukainen Juha; Ylitalo Kari; Kaartinen Maija; Kuusisto Johanna; Toivonen Lauri; Nieminen Markku S; Laakso Markku; Peuhkurinen Keijo
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy.
European heart journal 2004;25(10):885-93.
2004: Laukkanen O; Pihlajamäki J; Lindström J; Eriksson J; Valle T T; Hämäläinen H; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Tuomilehto J; Uusitupa M; Laakso M;
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study.
Diabetologia 2004;47(5):871-7.
2004: Kubaszek Agata; Markkanen Anu; Eriksson Johan G; Forsen Tom; Osmond Clive; Barker David J P; Laakso Markku
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth.
The Journal of clinical endocrinology and metabolism 2004;89(5):2044-7.
2004: Todorova Boryana; Kubaszek Agata; Pihlajamäki Jussi; Lindström Jaana; Eriksson Johan; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaakko; Uusitupa Matti; Laakso Markku;
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study.
The Journal of clinical endocrinology and metabolism 2004;89(5):2019-23.
2004: Laakso Markku
Gene variants, insulin resistance, and dyslipidaemia.
Current opinion in lipidology 2004;15(2):115-20.
2004: Pihlajamäki Jussi; Gylling Helena; Miettinen Tatu A; Laakso Markku
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.
Journal of lipid research 2004;45(3):507-12.
2004: Pihlajamäki Jussi; Vanhala Mauno; Vanhala Pasi; Laakso Markku
The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood.
Obesity research 2004;12(2):187-90.
2004: Pirinen Eija; Heikkinen Sami; Malkki Mari; Deeb Samir S; Jänne Juhani; Laakso Markku
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.
Biochimica et biophysica acta 2004;1676(2):149-54.
2004: Soinio Minna; Marniemi Jukka; Laakso Markku; Lehto Seppo; Rönnemaa Tapani
Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus.
Annals of internal medicine 2004;140(2):94-100.
2004: Hedman A; Hartikainen J; Vanninen E; Laitinen T; Jääskeläinen P; Laakso M; Peuhkurinen K; Kuusisto J
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.
Journal of molecular and cellular cardiology 2004;36(1):91-9.
2004: Jääskeläinen Pertti; Miettinen Raija; Kärkkäinen Päivi; Toivonen Lauri; Laakso Markku; Kuusisto Johanna
Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes.
Annals of medicine 2004;36(1):23-32.
2003: Kärkkäinen Satu; Miettinen Raija; Tuomainen Petri; Kärkkäinen Päivi; Heliö Tiina; Reissell Eeva; Kaartinen Maija; Toivonen Lauri; Nieminen Markku S; Kuusisto Johanna; Laakso Markku; Peuhkurinen Keijo
A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) 2003;81(12):795-800.
2003: Rajala U; Päivänsalo M; Laakso M; Pelkonen O; Suramo I; Keinänen-Kiukaanniemi S
Associations of blood pressure with carotid intima-media thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance.
Journal of human hypertension 2003;17(10):705-11.
2003: Laitinen Tomi; Huopio Hanna; Vauhkonen Ilkka; Camaro Cyril; Hartikainen Juha; Laakso Markku; Niskanen Leo
Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects.
Clinical science (London, England : 1979) 2003;105(3):315-22.
2003: Sivenius Katariina; Niskanen Leo; Laakso Markku; Uusitupa Matti
A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity.
Obesity research 2003;11(8):962-70.
2003: Eriksson Johan G; Osmond Clive; Lindi Virpi; Uusitupa Matti; Forsen Tom; Laakso Markku; Barker David
Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes.
Diabetes care 2003;26(8):2476-7.
2003: Pihlajamäki Jussi; Ylinen Mari; Karhapää Pauli; Vauhkonen Ilkka; Laakso Markku
The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.
Obesity research 2003;11(7):912-7.
2003: Kubaszek Agata; Pihlajamäki Jussi; Komarovski Vladislav; Lindi Virpi; Lindström Jaana; Eriksson Johan; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Tuomilehto Jaakko; Uusitupa Matti; Laakso Markku;
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
Diabetes 2003;52(7):1872-6.
2003: Lumiaho Anne; Pihlajamäki Jussi; Hartikainen Juha; Ikäheimo Risto; Miettinen Raija; Niemitukia Lea; Lampainen Erkki; Laakso Markku
Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;41(6):1219-24.
2003: Hedman Marja; Hartikainen Juha; Syvänne Mikko; Stjernvall Joachim; Hedman Antti; Kivelä Antti; Vanninen Esko; Mussalo Hanna; Kauppila Esa; Simula Sakari; Närvänen Outi; Rantala Arto; Peuhkurinen Keijo; Nieminen Markku S; Laakso Markku; Ylä-Herttuala Seppo
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
Circulation 2003;107(21):2677-83.
2003: Lindi Virpi; Schwab Ursula; Louheranta Anne; Laakso Markku; Vessby Bengt; Hermansen Kjeld; Storlien Len; Riccardi Gabriele; A Rivellese Angela;
Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation.
Molecular genetics and metabolism 2003;79(1):52-60.
2003: Pihlajamäki Jussi; Karhapää Pauli; Vauhkonen Ilkka; Kekäläinen Päivi; Kareinen Anu; Viitanen Laura; Pesonen Ullamari; Kallio Jaana; Uusitupa Matti; Laakso Markku
The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism.
Metabolism: clinical and experimental 2003;52(5):643-6.
2003: González-Sánchez José Luis; Martínez-Larrad María Teresa; Fernández-Pérez Cristina; Kubaszek Agata; Laakso Markku; Serrano-Ríos Manuel
K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.
Obesity research 2003;11(5):603-5.
2003: Kolehmainen M; Uusitupa M I J; Alhava E; Laakso M; Vidal H
Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects.
The Journal of clinical endocrinology and metabolism 2003;88(4):1717-22.
2003: Sipola Petri; Vanninen Esko; Aronen Hannu J; Lauerma Kirsi; Simula Sakari; Jääskeläinen Pertti; Laakso Markku; Peuhkurinen Keijo; Kuusisto Johanna; Kuikka Jyrki T
Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(4):487-93.
2003: Soinio Minna; Laakso Markku; Lehto Seppo; Hakala Paula; Rönnemaa Tapani
Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes.
Diabetes care 2003;26(3):619-24.
2003: Reimann F; Huopio H; Dabrowski M; Proks P; Gribble F M; Laakso M; Otonkoski T; Ashcroft F M
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.
Diabetologia 2003;46(2):241-9.
2003: Niskanen L; Lindi V; Erkkilä A; Sivenius K; Luoma J; Ylä-Herttuala S; Laakso M; Uusitupa M I j
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects.
Metabolism: clinical and experimental 2003;52(2):213-7.
2003: Kubaszek Agata; Pihlajamäki Jussi; Karhapää Pauli; Vauhkonen Ilkka; Laakso Markku
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.
Diabetes care 2003;26(2):464-7.
2003: Kubaszek Agata; Pihlajamäki Jussi; Punnonen Kari; Karhapää Pauli; Vauhkonen Ilkka; Laakso Markku
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.
Diabetes 2003;52(2):558-61.
2003: Huopio Hanna; Otonkoski Timo; Vauhkonen Ilkka; Reimann Frank; Ashcroft Frances M; Laakso Markku
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
Lancet 2003;361(9354):301-7.
2003: Sipola Petri; Lauerma Kirsi; Husso-Saastamoinen Minna; Kuikka Jyrki T; Vanninen Esko; Laitinen Tomi; Manninen Hannu; Niemi Pekka; Peuhkurinen Keijo; Jääskeläinen Pertti; Laakso Markku; Kuusisto Johanna; Aronen Hannu J
First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene.
Radiology 2003;226(1):129-37.
2003: Kossila Maija; Pihlajamäki Jussi; Kärkkäinen Päivi; Miettinen Raija; Kekäläinen Päivi; Vauhkonen Ilkka; Ylä-Herttuala Seppo; Laakso Markku
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.
Diabetes care 2003;26(1):179-82.
2003: Lumiaho Anne; Ikäheimo Risto; Pihlajamäki Jussi; Miettinen Raija; Niemitukia Lea; Vanninen Ritva; Lampainen Erkki; Laakso Markku
Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland.
Scandinavian journal of urology and nephrology 2003;37(4):352-8.
2002: Mussalo Hanna; Vanninen Esko; Ikäheimo Risto; Laitinen Tomi; Laakso Markku; Länsimies Esko; Hartikainen Juha
Baroreflex sensitivity in essential and secondary hypertension.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2002;12(6):465-71.
2002: González Sánchez J L; Serrano Ríos M; Fernández Perez C; Laakso M; Martínez Larrad M T
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(4):495-501.
2002: Huopio H; Jääskeläinen J; Komulainen J; Miettinen R; Kärkkäinen P; Laakso M; Tapanainen P; Voutilainen R; Otonkoski T
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism.
The Journal of clinical endocrinology and metabolism 2002;87(10):4502-7.
2002: Vakkilainen Juha; Pajukanta Päivi; Cantor Rita M; Nuotio Ilpo O; Lahdenperä Sanni; Ylitalo Kati; Pihlajamäki Jussi; Kovanen Petri T; Laakso Markku; Viikari Jorma S A; Peltonen Leena; Taskinen Marja-Riitta
Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.
European journal of human genetics : EJHG 2002;10(9):547-52.
2002: Lindi Virpi I; Uusitupa Matti I J; Lindström Jaana; Louheranta Anne; Eriksson Johan G; Valle Timo T; Hämäläinen Helena; Ilanne-Parikka Pirjo; Keinänen-Kiukaanniemi Sirkka; Laakso Markku; Tuomilehto Jaakko;
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.
Diabetes 2002;51(8):2581-6.
2002: Pajunen P; Syvänne M; Nieminen M S; Kareinen A; Viitanen L; Lehto S; Laakso M
Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families.
European journal of clinical investigation 2002;32(7):472-8.
2002: Jääskeläinen Pertti; Kuusisto Johanna; Miettinen Raija; Kärkkäinen Päivi; Kärkkäinen Satu; Heikkinen Sami; Peltola Paula; Pihlajamäki Jussi; Vauhkonen Ilkka; Laakso Markku
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland.
Journal of molecular medicine (Berlin, Germany) 2002;80(7):412-22.
2002: Kärkkäinen Satu; Peuhkurinen Keijo; Jääskeläinen Pertti; Miettinen Raija; Kärkkäinen Päivi; Kuusisto Johanna; Laakso Markku
No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy.
American heart journal 2002;143(6):E6.
2002: Laakso M; Matilainen V; Keinänen-Kiukaanniemi S
Association of neck circumference with insulin resistance-related factors.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(6):873-5.
2002: Erkkilä A T; Lindi V; Lehto S; Pyörälä K; Laakso M; Uusitupa M I J
Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2002;12(2):53-9.
2002: Erkkilä Arja T; Lindi Virpi; Lehto Seppo; Laakso Markku; Uusitupa Matti I J
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
Molecular genetics and metabolism 2002;75(3):260-4.
2002: Lehto Seppo; Niskanen Leo; Suhonen Matti; Rönnemaa Tapani; Saikku Pekka; Laakso Markku
Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients.
Archives of internal medicine 2002;162(5):594-9.
2002: Laakso Markku
Lipids in type 2 diabetes.
Seminars in vascular medicine 2002;2(1):59-66.
2002: Simula Sakari; Vanninen Esko; Viitanen Laura; Kareinen Anu; Lehto Seppo; Pajunen Pia; Syvänne Mikko; Kuikka Jyrki; Laakso Markku; Hartikainen Juha
Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(1):1-7.
2002: Huopio Hanna; Vauhkonen Ilkka; Komulainen Jorma; Niskanen Leo; Otonkoski Timo; Laakso Markku
Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion.
Diabetes care 2002;25(1):101-6.
2001: Viitanen L; Pihlajamäki J; Miettinen R; Kärkkäinen P; Vauhkonen I; Halonen P; Kareinen A; Lehto S; Laakso M
Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease.
Journal of molecular medicine (Berlin, Germany) 2001;79(12):732-7.
2001: Lumiaho A; Ikäheimo R; Miettinen R; Niemitukia L; Laitinen T; Rantala A; Lampainen E; Laakso M; Hartikainen J
Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(6):1208-16.
2001: Sivenius K; Lindi V; Niskanen L; Laakso M; Uusitupa M
Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(11):1609-14.
2001: Pihlajamäki J; Austin M; Edwards K; Laakso M
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia.
Diabetes 2001;50(10):2396-401.
2001: Mussalo H; Vanninen E; Ikäheimo R; Laitinen T; Laakso M; Länsimies E; Hartikainen J
Heart rate variability and its determinants in patients with severe or mild essential hypertension.
Clinical physiology (Oxford, England) 2001;21(5):594-604.
2001: Kuusisto J; Lempiäinen P; Mykkänen L; Laakso M
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.
Diabetes care 2001;24(9):1629-33.
2001: Kareinen A; Viitanen L; Halonen P; Lehto S; Laakso M
Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(8):1346-52.
2001: Wang H; Rissanen J; Miettinen R; Kärkkäinen P; Kekäläinen P; Kuusisto J; Mykkänen L; Karhapää P; Laakso M
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes 2001;50(8):1949-51.
2001: Lindi V; Sivenius K; Niskanen L; Laakso M; Uusitupa M I
Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects.
Diabetologia 2001;44(7):925-6.
2001: Viitanen L; Pihlajamäki J; Halonen P; Lehtonen M; Kareinen A; Lehto S; Laakso M
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease.
Atherosclerosis 2001;157(1):57-64.
2001: Pihlajamäki J; Valve R; Karjalainen L; Karhapää P; Vauhkonen I; Laakso M
The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance.
European journal of clinical investigation 2001;31(4):302-8.
2001: Erkkilä A T; Sarkkinen E S; Lindi V; Lehto S; Laakso M; Uusitupa M I
APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose.
The American journal of clinical nutrition 2001;73(4):746-52.
2001: Laakso M
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention.
Journal of internal medicine 2001;249(3):225-35.
2001: Vanhanen M; Kivipelto M; Koivisto K; Kuusisto J; Mykkänen L; Helkala E L; Hänninen T; Kervinen K; Kesäniemi Y A; Laakso M P; Soininen H; Laakso M
APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
Neurology 2001;56(5):655-9.
2001: Agren J J; Vidgren H M; Valve R S; Laakso M; Uusitupa M I
Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene.
The American journal of clinical nutrition 2001;73(1):31-5.
2000: Mustanoja S M; Hätönen T; Alila-Johansson A; Laakso M
Evidence for central alpha(2)-adrenergic modulation of rat pineal melatonin synthesis.
Brain research 2000;887(1):174-7.
2000: Rajala U; Qiao Q; Laakso M; Keinänen-Kiukaanniemi S
Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance.
Diabetes research and clinical practice 2000;50(3):231-9.
2000: Lindblom N; Hätönen T; Laakso M; Alila-Johansson A; Laipio M; Turpeinen U
Bright light exposure of a large skin area does not affect melatonin or bilirubin levels in humans.
Biological psychiatry 2000;48(11):1098-104.
2000: Pajukanta P; Cargill M; Viitanen L; Nuotio I; Kareinen A; Perola M; Terwilliger J D; Kempas E; Daly M; Lilja H; Rioux J D; Brettin T; Viikari J S; Rönnemaa T; Laakso M; Lander E S; Peltonen L
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
American journal of human genetics 2000;67(6):1481-93.
2000: Koivisto A M; Lempiäinen P; Koivisto K; Helkala E L; Mykkänen L; Kuusisto J; Kervinen K; Kesäniemi Y A; Laakso M; Soininen H
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
Neuroepidemiology 2000;19(6):327-32.
2000: Kekäläinen P; Sarlund H; Laakso M
Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance.
Metabolism: clinical and experimental 2000;49(10):1247-54.
2000: Rissanen J; Wang H; Miettinen R; Kärkkäinen P; Kekäläinen P; Mykkänen L; Kuusisto J; Karhapää P; Niskanen L; Uusitupa M; Laakso M
Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.
Diabetes care 2000;23(10):1533-8.
2000: Huopio H; Reimann F; Ashfield R; Komulainen J; Lenko H L; Rahier J; Vauhkonen I; Kere J; Laakso M; Ashcroft F; Otonkoski T
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
The Journal of clinical investigation 2000;106(7):897-906.
2000: Kossila M; Sinkovic M; Kärkkäinen P; Laukkanen M O; Miettinen R; Rissanen J; Kekäläinen P; Kuusisto J; Ylä-Herttuala S; Laakso M
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes 2000;49(10):1740-3.
2000: Pyörälä M; Miettinen H; Laakso M; Pyörälä K
Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study.
Diabetes care 2000;23(8):1097-102.
2000: Pihlajamäki J; Miettinen R; Valve R; Karjalainen L; Mykkänen L; Kuusisto J; Deeb S; Auwerx J; Laakso M
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.
Atherosclerosis 2000;151(2):567-74.
2000: Vauhkonen I K; Niskanen L K; Mykkänen L; Haffner S M; Uusitupa M I; Laakso M
Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(2):251-60.
2000: Pihlajamäki J; Karjalainen L; Karhapää P; Vauhkonen I; Taskinen M R; Deeb S S; Laakso M
G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1789-95.
2000: Niskanen L; Karvonen M K; Valve R; Koulu M; Pesonen U; Mercuri M; Rauramaa R; Töyry J; Laakso M; Uusitupa M I
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
The Journal of clinical endocrinology and metabolism 2000;85(6):2266-9.
2000: Pulkkinen A; Viitanen L; Kareinen A; Lehto S; Laakso M
Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes.
Diabetes care 2000;23(6):864.
2000: Pulkkinen A; Viitanen L; Kareinen A; Lehto S; Laakso M
MspI polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of HDL cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic patients with coronary heart disease.
Diabetes care 2000;23(6):791-5.
2000: Sivenius K; Valve R; Lindi V; Niskanen L; Laakso M; Uusitupa M
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(4):514-9.
2000: Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes.
Diabetologia 2000;43(2):148-55.
2000: Pyörälä M; Miettinen H; Halonen P; Laakso M; Pyörälä K
Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):538-44.
2000: Heikkinen S; Suppola S; Malkki M; Deeb S S; Jänne J; Laakso M
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):91-6.
2000: Rissanen J; Markkanen A; Kärkkäinen P; Pihlajamäki J; Kekäläinen P; Mykkänen L; Kuusisto J; Karhapää P; Niskanen L; Laakso M
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.
Diabetes care 2000;23(1):70-3.
2000: Laitinen M; Hartikainen J; Hiltunen M O; Eränen J; Kiviniemi M; Närvänen O; Mäkinen K; Manninen H; Syvänne M; Martin J F; Laakso M; Ylä-Herttuala S
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty.
Human gene therapy 2000;11(2):263-70.
2000: Vauhkonen I; Niskanen L; Knip M; Ilonen J; Vanninen E; Kainulainen S; Uusitupa M; Laakso M
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults.
Diabetologia 2000;43(1):69-78.
2000: Pihlajamäki J; Karjalainen L; Karhapää P; Vauhkonen I; Laakso M
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):164-70.
2000: Pulkkinen A; Viitanen L; Kareinen A; Lehto S; Vauhkonen I; Laakso M
Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease.
Journal of molecular medicine (Berlin, Germany) 2000;78(7):372-9.
2000: Niskanen L; Voutilainen-Kaunisto R; Teräsvirta M; Karvonen M K; Valve R; Pesonen U; Laakso M; Uusitupa M I; Koulu M
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2000;108(3):235-6.
1999: Jääskeläinen P; Miettinen R; Silvennoinen K; Vauhkonen I; Laakso M; Kuusisto J
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from eastern Finland.
Journal of molecular and cellular cardiology 1999;31(11):2031-6.
1999: Valve R; Sivenius K; Miettinen R; Pihlajamäki J; Rissanen A; Deeb S S; Auwerx J; Uusitupa M; Laakso M
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.
The Journal of clinical endocrinology and metabolism 1999;84(10):3708-12.
1999: Sivenius J; Cunha L; Diener H C; Forbes C; Laakso M; Lowenthal A; Smets P; Riekkinen P
Antiplatelet treatment does not reduce the severity of subsequent stroke. European Stroke Prevention Study 2 Working Group.
Neurology 1999;53(4):825-9.
1999: Tikanoja T; Jääskeläinen P; Laakso M; Kuusisto J
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children.
The American journal of cardiology 1999;84(4):485-6.
1999: Laivuori H M; Laakso M; Tikkanen M J; Cacciatore B; Ylikorkala R O; Kaaja R J
Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia.
Journal of hypertension 1999;17(8):1189-94.
1999: Heikkinen S; Pietilä M; Halmekytö M; Suppola S; Pirinen E; Deeb S S; Jänne J; Laakso M
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
The Journal of biological chemistry 1999;274(32):22517-23.
1999: Kaaja R; Laivuori H; Laakso M; Tikkanen M J; Ylikorkala O
Evidence of a state of increased insulin resistance in preeclampsia.
Metabolism: clinical and experimental 1999;48(7):892-6.
1999: Pulkkinen A; Kareinen A; Saarinen L; Heikkinen S; Lehto S; Laakso M
The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients.
Metabolism: clinical and experimental 1999;48(7):853-6.
1999: Heinonen P; Koulu M; Pesonen U; Karvonen M K; Rissanen A; Laakso M; Valve R; Uusitupa M; Scheinin M
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.
The Journal of clinical endocrinology and metabolism 1999;84(7):2429-33.
1999: Lempiäinen P; Mykkänen L; Pyörälä K; Laakso M; Kuusisto J
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.
Circulation 1999;100(2):123-8.
1999: Overmyer M; Helisalmi S; Soininen H; Laakso M; Riekkinen P; Alafuzoff I
Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.
Dementia and geriatric cognitive disorders 1999;10(4):252-7.
1999: Kuusisto J; Laakso M
Prandial glucose regulation and cardiovascular disease in type 2 diabetes.
European journal of clinical investigation 1999;29 Suppl 2():7-11.
1999: Laitinen T; Vauhkonen I K; Niskanen L K; Hartikainen J E; Länsimies E A; Uusitupa M I; Laakso M
Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects.
Diabetes 1999;48(6):1295-9.
1999: Laakso M
Hyperglycemia and cardiovascular disease in type 2 diabetes.
Diabetes 1999;48(5):937-42.
1999: Pajukanta P; Terwilliger J D; Perola M; Hiekkalinna T; Nuotio I; Ellonen P; Parkkonen M; Hartiala J; Ylitalo K; Pihlajamäki J; Porkka K; Laakso M; Viikari J; Ehnholm C; Taskinen M R; Peltonen L
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
American journal of human genetics 1999;64(5):1453-63.
1999: Overmyer M; Helisalmi S; Soininen H; Laakso M; Riekkinen P; Alafuzoff I
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
Acta neuropathologica 1999;97(4):383-92.
1999: Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):1014-9.
1999: Kekäläinen P; Sarlund H; Pyörälä K; Laakso M
Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes.
Diabetes care 1999;22(1):86-92.
1999: Niskanen L; Uusitupa M; Laakso M
[Drug therapy of hyperglycemia and the prognosis of adult-onset diabetes mellitus]
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1122-4.
1999: Kuusisto J; Jääskeläinen P; Laakso M
[Sarcomere gene mutations--a cause of hypertrophic cardiomyopathy]
Duodecim; lääketieteellinen aikakauskirja 1999;115(9):997-8.
1998: Vauhkonen I; Niskanen L; Haffner S; Kainulainen S; Uusitupa M; Laakso M
Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(6):598-604.
1998: Pihlajamäki J; Rissanen J; Valve R; Heikkinen S; Karjalainen L; Laakso M
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia.
Metabolism: clinical and experimental 1998;47(11):1397-402.
1998: Jääskeläinen P; Soranta M; Miettinen R; Saarinen L; Pihlajamäki J; Silvennoinen K; Tikanoja T; Laakso M; Kuusisto J
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.
Journal of the American College of Cardiology 1998;32(6):1709-16.
1998: Malkki M; Laakso M; Deeb S S
Functional consequences of naturally occurring variants of human hexokinase II.
Diabetologia 1998;41(10):1205-9.
1998: Rajala U; Laakso M; Qiao Q; Keinänen-Kiukaanniemi S
Prevalence of retinopathy in people with diabetes, impaired glucose tolerance, and normal glucose tolerance.
Diabetes care 1998;21(10):1664-9.
1998: Agren J J; Valve R; Vidgren H; Laakso M; Uusitupa M
Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1606-10.
1998: Karjalainen L; Pihlajamäki J; Karhapää P; Laakso M
Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1548-53.
1998: Karvonen M K; Pesonen U; Heinonen P; Laakso M; Rissanen A; Naukkarinen H; Valve R; Uusitupa M I; Koulu M
Identification of new sequence variants in the leptin gene.
The Journal of clinical endocrinology and metabolism 1998;83(9):3239-42.
1998: Pyörälä M; Miettinen H; Laakso M; Pyörälä K
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Stroke; a journal of cerebral circulation 1998;29(9):1860-6.
1998: Pyörälä M; Miettinen H; Laakso M; Pyörälä K
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.
Circulation 1998;98(5):398-404.
1998: Laitinen M; Mäkinen K; Manninen H; Matsi P; Kossila M; Agrawal R S; Pakkanen T; Luoma J S; Viita H; Hartikainen J; Alhava E; Laakso M; Ylä-Herttuala S
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia.
Human gene therapy 1998;9(10):1481-6.
1998: Rissanen J; Saarinen L; Heikkinen S; Kekäläinen P; Mykkänen L; Kuusisto J; Deeb S S; Laakso M
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
Diabetes care 1998;21(7):1194-7.
1998: Saarinen L; Pulkkinen A; Kareinen A; Heikkinen S; Lehto S; Laakso M
Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.
Diabetes care 1998;21(5):849-50.
1998: Laakso M; Lehto S
Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance.
Atherosclerosis 1998;137 Suppl():S65-73.
1998: Laakso M
Hypertension and macrovascular disease--the killing fields of NIDDM.
Diabetes research and clinical practice 1998;39 Suppl():S27-33.
1998: Tikkanen M J; Laakso M; Ilmonen M; Helve E; Kaarsalo E; Kilkki E; Saltevo J
Treatment of hypercholesterolemia and combined hyperlipidemia with simvastatin and gemfibrozil in patients with NIDDM. A multicenter comparison study.
Diabetes care 1998;21(4):477-81.
1998: Pajukanta P; Nuotio I; Terwilliger J D; Porkka K V; Ylitalo K; Pihlajamäki J; Suomalainen A J; Syvänen A C; Lehtimäki T; Viikari J S; Laakso M; Taskinen M R; Ehnholm C; Peltonen L
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Nature genetics 1998;18(4):369-73.
1998: Valve R; Heikkinen S; Rissanen A; Laakso M; Uusitupa M
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns.
Diabetologia 1998;41(3):357-61.
1998: Vanhanen M; Koivisto K; Kuusisto J; Mykkänen L; Helkala E L; Hänninen T; Riekkinen P; Soininen H; Laakso M
Cognitive function in an elderly population with persistent impaired glucose tolerance.
Diabetes care 1998;21(3):398-402.
1998: Lehto S; Niskanen L; Rönnemaa T; Laakso M
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus.
Stroke; a journal of cerebral circulation 1998;29(3):635-9.
1998: Riekkinen M; Soininen H; Riekkinen P; Kuikka J; Laakso M; Helkala E L; Partanen J; Riekkinen P
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.
Neuroscience 1998;83(2):471-9.
1998: Vauhkonen I; Niskanen L; Vanninen E; Kainulainen S; Uusitupa M; Laakso M
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands.
The Journal of clinical investigation 1998;101(1):86-96.
1997: Rissanen J; Pihlajamäki J; Heikkinen S; Kekäläinen P; Mykkänen L; Kuusisto J; Kolle A; Laakso M
New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.
Diabetologia 1997;40(11):1313-9.
1997: Kuusisto J; Koivisto K; Mykkänen L; Helkala E L; Vanhanen M; Hänninen T; Kervinen K; Kesäniemi Y A; Riekkinen P J; Laakso M
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.
BMJ (Clinical research ed.) 1997;315(7115):1045-9.
1997: Laitinen M; Zachary I; Breier G; Pakkanen T; Häkkinen T; Luoma J; Abedi H; Risau W; Soma M; Laakso M; Martin J F; Ylä-Herttuala S
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries.
Human gene therapy 1997;8(15):1737-44.
1997: Riekkinen P; Pääkkönen A; Karhu J; Partanen J; Soininen H; Laakso M; Riekkine P
THA disrupts mismatch negativity in Alzheimer disease.
Psychopharmacology 1997;133(2):203-6.
1997: Mykkänen L; Haffner S M; Rönnemaa T; Bergman R N; Laakso M
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.
American journal of epidemiology 1997;146(4):315-21.
1997: Sipiläinen R; Uusitupa M; Heikkinen S; Rissanen A; Laakso M
Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects.
The Journal of clinical endocrinology and metabolism 1997;82(8):2629-32.
1997: Rissanen J; Kuopusjärvi J; Pihlajamäki J; Sipiläinen R; Heikkinen S; Vanhala M; Kekäläinen P; Kuusisto J; Laakso M
The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome.
Diabetes care 1997;20(8):1319-23.
1997: Lehto S; Rönnemaa T; Haffner S M; Pyörälä K; Kallio V; Laakso M
Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM.
Diabetes 1997;46(8):1354-9.
1997: Jäkälä P; Hänninen T; Ryynänen M; Laakso M; Partanen K; Mannermaa A; Soininen H
Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
The Journal of clinical investigation 1997;100(2):331-8.
1997: Pihlajamäki J; Rissanen J; Heikkinen S; Karjalainen L; Laakso M
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(6):1039-44.
1997: Riekkinen P; Riekkinen M; Soininen H; Kuikka J; Laakso M; Riekkinen P
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease.
Neuroreport 1997;8(8):1845-9.
1997: Vidgren H M; Sipiläinen R H; Heikkinen S; Laakso M; Uusitupa M I
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects.
European journal of clinical investigation 1997;27(5):405-8.
1997: Vanhanen M; Koivisto K; Karjalainen L; Helkala E L; Laakso M; Soininen H; Riekkinen P
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function.
Neuroreport 1997;8(6):1527-30.
1997: Rissanen J; Pihlajamäki J; Heikkinen S; Kekäläinen P; Kuusisto J; Laakso M
The Ala54Thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects.
Diabetes 1997;46(4):711-2.
1997: Mustonen J; Uusitupa M; Mäntysaari M; Länsimies E; Pyörälä K; Laakso M
Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease.
Journal of internal medicine 1997;241(3):227-35.
1997: Sipiläinen R; Uusitupa M; Heikkinen S; Rissanen A; Laakso M
Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns.
Diabetes 1997;46(1):77-80.
1996: Miettinen H; Haffner S M; Lehto S; Rönnemaa T; Pyörälà K; Laakso M
Retinopathy predicts coronary heart disease events in NIDDM patients.
Diabetes care 1996;19(12):1445-8.
1996: Vanhanen M; Karhu J; Koivisto K; Pääkkönen A; Partanen J; Laakso M; Riekkinen P
ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM.
Neuroreport 1996;7(15-17):2767-71.
1996: Rönnemaa T; Rönnemaa E M; Puukka P; Pyörälä K; Laakso M
Smoking is independently associated with high plasma insulin levels in nondiabetic men.
Diabetes care 1996;19(11):1229-32.
1996: Miettinen H; Haffner S M; Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects.
Stroke; a journal of cerebral circulation 1996;27(11):2033-9.
1996: Laakso M; Kuusisto J
Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus.
Annals of medicine 1996;28(5):415-8.
1996: Kekäläinen P; Sarlund H; Farin P; Kaukanen E; Yang X; Laakso M
Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance.
American journal of epidemiology 1996;144(8):742-8.
1996: Laakso M; Karjalainen L; Lempiäinen-Kuosa P
Effects of losartan on insulin sensitivity in hypertensive subjects.
Hypertension 1996;28(3):392-6.
1996: Laakso M
Insulin resistance and coronary heart disease.
Current opinion in lipidology 1996;7(4):217-26.
1996: Laakso M
Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus.
Annals of medicine 1996;28(4):341-5.
1996: Lehto S; Niskanen L; Suhonen M; Rönnemaa T; Laakso M
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):978-83.
1996: Kekäläinen P; Sarlund H; Pyörälä K; Laakso M
Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus.
Atherosclerosis 1996;123(1-2):203-13.
1996: Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Risk factors predicting lower extremity amputations in patients with NIDDM.
Diabetes care 1996;19(6):607-12.
1996: Hanninen T; Koivisto K; Reinikainen K J; Helkala E L; Soininen H; Mykkänen L; Laakso M; Riekkinen P J
Prevalence of ageing-associated cognitive decline in an elderly population.
Age and ageing 1996;25(3):201-5.
1996: Mykkanen L; Haffner S M; Ronnemaa T; Watanabe R M; Laakso M
Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity?
Journal of hypertension 1996;14(3):399-405.
1996: Helkala E L; Koivisto K; Hanninen T; Vanhanen M; Kervinen K; Kuusisto J; Mykkanen L; Kesaniemi Y A; Laakso M; Riekkinen P
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study.
Neuroscience letters 1996;204(3):177-80.
1996: Niskanen L; Uusitupa M; Sarlund H; Siitonen O; Paljärvi L; Laakso M
The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(2):154-60.
1996: Lehto S; Rönnemaa T; Pyörälä K; Laakso M
Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes.
Stroke; a journal of cerebral circulation 1996;27(1):63-8.
1995: Mykkänen L; Haffner S M; Kuusisto J; Pyörälä K; Hales C N; Laakso M
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects.
Diabetologia 1995;38(10):1176-82.
1995: Austin M A; Mykkänen L; Kuusisto J; Edwards K L; Nelson C; Haffner S M; Pyörälä K; Laakso M
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women.
Circulation 1995;92(7):1770-8.
1995: Kuusisto J; Mykkänen L; Kervinen K; Kesäniemi Y A; Laakso M
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(9):1280-6.
1995: Hänninen T; Hallikainen M; Koivisto K; Helkala E L; Reinikainen K J; Soininen H; Mykkänen L; Laakso M; Pyörälä K; Riekkinen P J
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.
Journal of the American Geriatrics Society 1995;43(9):1007-15.
1995: Niskanen L; Sarlund H; Laakso M
Metabolic defects in persistent impaired glucose tolerance are related to the family history of non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1995;44(8):1099-104.
1995: Riekkinen P; Soininen H; Helkala E L; Partanen K; Laakso M; Vanhanen M; Riekkinen P
Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease.
Neuroreport 1995;6(9):1297-300.
1995: Virtaniemi J; Kuusisto J; Karjalainen L; Karjalainen S; Laakso M
Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus.
American journal of otolaryngology 1995;16(3):172-6.
1995: Helkala E L; Koivisto K; Hänninen T; Vanhanen M; Kervinen K; Kuusisto J; Mykkänen L; Kesäniemi Y A; Laakso M; Riekkinen P
The association of apolipoprotein E polymorphism with memory: a population based study.
Neuroscience letters 1995;191(3):141-4.
1995: Laakso M; Malkki M; Kekäläinen P; Kuusisto J; Deeb S S
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Diabetologia 1995;38(5):617-22.
1995: Laakso M; Rönnemaa T; Lehto S; Puukka P; Kallio V; Pyörälä K
Does NIDDM increase the risk for coronary heart disease similarly in both low- and high-risk populations?
Diabetologia 1995;38(4):487-93.
1995: Koivisto K; Reinikainen K J; Hänninen T; Vanhanen M; Helkala E L; Mykkänen L; Laakso M; Pyörälä K; Riekkinen P J
Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland.
Neurology 1995;45(4):741-7.
1995: Laakso M; Soininen H; Partanen K; Hallikainen M; Lehtovirta M; Hänninen T; Vainio P; Riekkinen P J
The interuncal distance in Alzheimer disease and age-associated memory impairment.
AJNR. American journal of neuroradiology 1995;16(4):727-34.
1995: Laakso M; Malkki M; Deeb S S
Amino acid substitutions in hexokinase II among patients with NIDDM.
Diabetes 1995;44(3):330-4.
1995: Laakso M; Malkki M; Kekäläinen P; Kuusisto J; Mykkänen L; Deeb S S
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
Diabetes care 1995;18(3):398-400.
1995: Kuusisto J; Mykkänen L; Pyörälä K; Laakso M
Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease.
Circulation 1995;91(3):831-7.
1995: Sivenius J; Riekkinen P J; Laakso M
Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes.
BMJ (Clinical research ed.) 1995;310(6971):25-6.
1994: Mykkänen L; Kuusisto J; Pyörälä K; Laakso M; Haffner S M
Increased risk of non-insulin-dependent diabetes mellitus in elderly hypertensive subjects.
Journal of hypertension 1994;12(12):1425-32.
1994: Malkki M; Laakso M; Deeb S S
Structure of the human hexokinase II gene.
Biochemical and biophysical research communications 1994;205(1):490-6.
1994: Virtaniemi J; Laakso M; Nuutinen J; Karjalainen S; Vartiainen E
Hearing thresholds in insulin-dependent diabetic patients.
The Journal of laryngology and otology 1994;108(10):837-41.
1994: Matsi P J; Manninen H I; Laakso M; Jaakkola P
Impact of risk factors on limb salvage after angioplasty in chronic critical lower limb ischemia. A prospective trial.
Angiology 1994;45(9):797-804.
1994: Laakso M; Malkki M; Kekäläinen P; Kuusisto J; Deeb S S
Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.
The Journal of clinical investigation 1994;94(3):1141-6.
1994: Mykkänen L; Rönnemaa T; Marniemi J; Haffner S M; Bergman R; Laakso M
Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1264-71.
1994: Kuusisto J; Mykkänen L; Pyörälä K; Laakso M
NIDDM and its metabolic control predict coronary heart disease in elderly subjects.
Diabetes 1994;43(8):960-7.
1994: Mustonen J N; Uusitupa M I; Laakso M; Vanninen E; Länsimies E; Kuikka J T; Pyörälä K
Left ventricular systolic function in middle-aged patients with diabetes mellitus.
The American journal of cardiology 1994;73(16):1202-8.
1994: Kuusisto J; Mykkänen L; Pyörälä K; Laakso M
Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly subjects.
Stroke; a journal of cerebral circulation 1994;25(6):1157-64.
1994: Matsi P J; Manninen H I; Vanninen R L; Suhonen M T; Oksala I; Laakso M; Hakkarainen T; Soimakallio S
Femoropopliteal angioplasty in patients with claudication: primary and secondary patency in 140 limbs with 1-3-year follow-up.
Radiology 1994;191(3):727-33.
1994: Mykkänen L; Haffner S M; Rönnemaa T; Bergman R; Leino A; Laakso M
Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins?
Metabolism: clinical and experimental 1994;43(4):523-8.
1994: Mykkänen L; Kuusisto J; Haffner S M; Pyörälä K; Laakso M
Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(4):518-26.
1994: Mykkänen L; Haffner S M; Kuusisto J; Pyorälä K; Laakso M
Microalbuminuria precedes the development of NIDDM.
Diabetes 1994;43(4):552-7.
1994: Karhapää P; Malkki M; Laakso M
Isolated low HDL cholesterol. An insulin-resistant state.
Diabetes 1994;43(3):411-7.
1994: Virtaniemi J; Laakso M; Nuutinen J; Karjalainen S; Vartiainen E
Acoustic-reflex responses in patients with insulin-dependent diabetes mellitus.
American journal of otolaryngology 1994;15(2):109-13.
1994: Hänninen T; Reinikainen K J; Helkala E L; Koivisto K; Mykkänen L; Laakso M; Pyörälä K; Riekkinen P J
Subjective memory complaints and personality traits in normal elderly subjects.
Journal of the American Geriatrics Society 1994;42(1):1-4.
1993: Niskanen L; Laakso M
Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus.
Metabolism: clinical and experimental 1993;42(12):1541-5.
1993: Virtaniemi J; Laakso M; Kärjä J; Nuutinen J; Karjalainen S
Auditory brainstem latencies in type I (insulin-dependent) diabetic patients.
American journal of otolaryngology 1993;14(6):413-8.
1993: Deeb S S; Malkki M; Laakso M
Human hexokinase II: sequence and homology to other hexokinases.
Biochemical and biophysical research communications 1993;197(1):68-74.
1993: Kuusisto J; Koivisto K; Mykkänen L; Helkala E L; Vanhanen M; Hänninen T; Pyörälä K; Riekkinen P; Laakso M
Essential hypertension and cognitive function. The role of hyperinsulinemia.
Hypertension 1993;22(5):771-9.
1993: Laakso M; Lehto S; Penttilä I; Pyörälä K
Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes.
Circulation 1993;88(4 Pt 1):1421-30.
1993: Karhapää P; Voutilainen E; Malkki M; Laakso M
Obese men with type IIB hyperlipidemia are insulin resistant.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(10):1469-75.
1993: Sivenius J; Riekkinen P J; Lowenthal A; Smets P; Laakso M
Antiplatelet therapy is effective in primary prevention of myocardial infarction in patients with a previous cerebrovascular ischemic event.
Archives of neurology 1993;50(7):710-3.
1993: Schwab U; Uusitupa M; Karhapää P; Mäkimattila S; Räsänen M; Mäkinen E; Laakso M
Effects of two fat-modified diets on glucose and lipid metabolism in healthy subjects.
Annals of the New York Academy of Sciences 1993;683():279-80.
1993: Mykkänen L; Kuusisto J; Pyörälä K; Laakso M
Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects.
Diabetologia 1993;36(6):553-9.
1993: Mykkänen L; Laakso M; Pyörälä K
High plasma insulin level associated with coronary heart disease in the elderly.
American journal of epidemiology 1993;137(11):1190-202.
1993: Ukkola O; Kervinen K; Salmela P I; von Dickhoff K; Laakso M; Kesäniemi Y A
Apolipoprotein E phenotype is related to macro- and microangiopathy in patients with non-insulin-dependent diabetes mellitus.
Atherosclerosis 1993;101(1):9-15.
1993: Laakso M
How good a marker is insulin level for insulin resistance?
American journal of epidemiology 1993;137(9):959-65.
1993: Mustonen J; Laakso M; Hirvonen T; Mutru O; Pirnes M; Vainio P; Kuikka J T; Rautio P; Länsimies E
Abnormalities in left ventricular diastolic function in male patients with rheumatoid arthritis without clinically evident cardiovascular disease.
European journal of clinical investigation 1993;23(4):246-53.
1993: Virtaniemi J; Laakso M; Nuutinen J; Karjalainen S; Vartiainen E
Voluntary eye movement tests in patients with insulin-dependent diabetes mellitus.
Acta oto-laryngologica 1993;113(2):123-7.
1993: Sivenius J; Riekkinen P J; Laakso M; Smets P; Lowenthal A
European Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderly.
Acta neurologica Scandinavica 1993;87(2):111-4.
1993: Siitonen O I; Niskanen L K; Laakso M; Siitonen J T; Pyörälä K
Lower-extremity amputations in diabetic and nondiabetic patients. A population-based study in eastern Finland.
Diabetes care 1993;16(1):16-20.
1993: Karhapää P; Voutilainen E; Kovanen P T; Laakso M
Insulin resistance in familial and nonfamilial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):41-7.
1993: Virtaniemi J; Laakso M; Nuutinen J; Karjalainen S; Vartiainen E
Tympanometry in patients with insulin-dependent diabetes mellitus.
Scandinavian audiology 1993;22(4):217-22.
1992: Laakso M
Dyslipidaemias, insulin resistance and atherosclerosis.
Annals of medicine 1992;24(6):505-9.
1992: Karhapää P; Uusitupa M; Voutilainen E; Laakso M
Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia.
Clinical pharmacology and therapeutics 1992;52(6):620-6.
1992: Mykkänen L; Laakso M; Pyörälä K
Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1992;16(9):695-704.
1992: Mykkänen L; Laakso M; Pyörälä K
Asymptomatic hyperglycemia and atherosclerotic vascular disease in the elderly.
Diabetes care 1992;15(8):1020-30.
1992: Koivisto K; Helkala E L; Reinikainen K J; Hänninen T; Mykkänen L; Laakso M; Pyörälä K; Riekkinen P J
Population-based dementia screening program in Kuopio: the effect of education, age, and sex on brief neuropsychological tests.
Journal of geriatric psychiatry and neurology 1992;5(3):162-71.
1992: Uusitupa M I; Mykkänen L; Siitonen O; Laakso M; Sarlund H; Kolehmainen P; Räsänen T; Kumpulainen J; Pyörälä K
Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels.
The British journal of nutrition 1992;68(1):209-16.
1992: Sivenius J; Laakso M; Riekkinen P; Smets P; Lowenthal A
European stroke prevention study: effectiveness of antiplatelet therapy in diabetic patients in secondary prevention of stroke.
Stroke; a journal of cerebral circulation 1992;23(6):851-4.
1992: Sarlund H; Pyörälä K; Penttilä I; Laakso M
Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(6):657-63.
1991: Laakso M; Kesäniemi A; Kervinen K; Jauhiainen M; Pyörälä K
Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes.
BMJ (Clinical research ed.) 1991;303(6811):1159-62.
1991: Sivenius J; Riekkinen P J; Kilpeläinen H; Laakso M; Penttilä I
Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European Stroke Prevention Study (ESPS).
Acta neurologica Scandinavica 1991;84(4):286-90.
1991: Sivenius J; Laakso M; Penttilä I M; Smets P; Lowenthal A; Riekkinen P J
The European Stroke Prevention Study: results according to sex.
Neurology 1991;41(8):1189-92.
1991: Laakso M; Sarlund H; Salonen R; Suhonen M; Pyörälä K; Salonen J T; Karhapää P
Asymptomatic atherosclerosis and insulin resistance.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):1068-76.
1991: Mykkänen L; Laakso M; Penttilä I; Pyörälä K
Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly.
Atherosclerosis 1991;88(2-3):153-61.
1991: Sivenius J; Riekkinen P J; Smets P; Laakso M; Lowenthal A
The European Stroke Prevention Study (ESPS): results by arterial distribution.
Annals of neurology 1991;29(6):596-600.
1991: Laakso M; Reunanen A; Klaukka T; Aromaa A; Maatela J; Pyörälä K
Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987.
American journal of epidemiology 1991;133(9):850-7.
1991: Sarlund H; Laakso M; Voutilainen E; Penttilä I; Pyörälä K
Familial aggregation of non-insulin dependent diabetes and coronary heart disease are accompanied by different effects on serum lipids, lipoproteins and apolipoproteins.
Atherosclerosis 1991;86(1):17-29.
1991: Kuikka J T; Mustonen J N; Uusitupa M I; Rautio P; Vanninen E; Laakso M; Länsimies E; Pyörälä K
Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid.
European journal of nuclear medicine 1991;18(7):475-81.
1990: Mykkänen L; Laakso M; Uusitupa M; Pyörälä K
Prevalence of diabetes and impaired glucose tolerance in elderly subjects and their association with obesity and family history of diabetes.
Diabetes care 1990;13(11):1099-105.
1990: Uusitupa M I; Laakso M; Sarlund H; Majander H; Takala J; Penttilä I
Effects of a very-low-calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics.
The American journal of clinical nutrition 1990;51(5):768-73.
1990: Laakso M; Pyörälä K
Plasma lipids and lipoproteins in diabetes: lessons from population-based studies.
The Journal of diabetic complications 1990;4(2):39-41.
1990: Laakso M; Suhonen M; Julkunen R; Pyörälä K
Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study.
Gut 1990;31(3):344-7.
1990: Laakso M; Sarlund H; Mykkänen L
Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance.
Arteriosclerosis (Dallas, Tex.) 1990;10(2):223-31.
1990: Laakso M; Pyörälä K
Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes.
Metabolism: clinical and experimental 1990;39(2):117-22.
1989: Laakso M; Sarlund H; Mykkänen L
Essential hypertension and insulin resistance in non-insulin-dependent diabetes.
European journal of clinical investigation 1989;19(6):518-26.
1989: Laakso M; Rönnemaa T; Sarlund H; Pyörälä K; Kallio V
Factors associated with fasting and postglucagon plasma C-peptide levels in middle-aged insulin-treated diabetic patients.
Diabetes care 1989;12(2):83-8.
1989: Uusitupa M; Laakso M; Sarlund H; Majander H; Takala J; Penttilä I
Long term effects of a very low calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics.
International journal of obesity 1989;13 Suppl 2():163-4.
1988: Mustonen J N; Uusitupa M I; Tahvanainen K; Talwar S; Laakso M; Länsimies E; Kuikka J T; Pyörälä K
Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease.
The American journal of cardiology 1988;62(17):1273-9.
1988: Uusitupa M; Mustonen J; Laakso M; Vainio P; Länsimies E; Talwar S; Pyörälä K
Impairment of diastolic function in middle-aged type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease.
Diabetologia 1988;31(11):783-91.
1988: Laakso M; Pyörälä K
Lipid and lipoprotein abnormalities in diabetic patients with peripheral vascular disease.
Atherosclerosis 1988;74(1-2):55-63.
1988: Laakso M; Uusitupa M; Takala J; Majander H; Reijonen T; Penttilä I
Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects.
Metabolism: clinical and experimental 1988;37(11):1092-100.
1988: Mustonen J; Laakso M; Uusitupa M; Sarlund H; Pyörälä K; Rautio P; Kuikka J; Länsimies E
Improvement of left ventricular function after starting insulin treatment in patients with non-insulin-dependent diabetes.
Diabetes research (Edinburgh, Scotland) 1988;9(1):27-30.
1988: Laakso M; Rönnemaa T; Pyörälä K; Kallio V; Puukka P; Penttilä I
Atherosclerotic vascular disease and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects in Finland.
Diabetes care 1988;11(6):449-63.
1988: Reinikainen K J; Paljärvi L; Huuskonen M; Soininen H; Laakso M; Riekkinen P J
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease.
Journal of the neurological sciences 1988;84(1):101-16.
1988: Reinikainen K J; Riekkinen P J; Paljärvi L; Soininen H; Helkala E L; Jolkkonen J; Laakso M
Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data.
Neurochemical research 1988;13(2):135-46.
1988: Laakso M; Sarlund H; Korhonen T; Voutilainen E; Majander H; Hakala P; Uusitupa M; Pyörälä K
Stopping insulin treatment in middle-aged diabetic patients with high postglucagon plasma C-peptide. Effect on glycaemic control, serum lipids and lipoproteins.
Acta medica Scandinavica 1988;223(1):61-8.
1987: Laakso M; Sarlund H; Ehnholm C; Voutilainen E; Aro A; Pyörälä K
Relationship between postheparin plasma lipases and high-density lipoprotein cholesterol in different types of diabetes.
Diabetologia 1987;30(9):703-6.
1984: Laakso M; Suhonen M; Helin M
[Mediastinal lipomatosis simulating cardiomegaly]
Duodecim; lääketieteellinen aikakauskirja 1984;100(2):96-9.

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