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Reino Laatikainen

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Magnetic Resonance Spectroscopy

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Pekka K Poutiainen; Ari E Hinkkanen; Reino Laatikainen; Jorma J Palvimo; Topi K Väisänen; Arto Valkonen; Juha Tapio Pulkkinen
Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.
Tuulia Tynkkynen; Tommi Hassinen; Pasi Soininen; Mika Tiainen; Reino Laatikainen
(1) H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments.
Peter Würtz; Markku J Savolainen; Pasi Soininen; Matti Tarkka; Russell Thomson; Tuulia Tynkkynen; Jorma S Viikari; Mika Ala-Korpela; Antti Jula; Markus Juonala; Mika Kähönen; Antti J Kangas; Pekka J Karhunen; Pekka Kuukasjärvi; Reino Laatikainen; Jari Laurikka; Terho Lehtimäki; Costan G Magnussen; Juho R Raiko; Olli T Raitakari
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis.

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All Publications

2013: Pekka K Poutiainen; Ari E Hinkkanen; Reino Laatikainen; Jorma J Palvimo; Topi K Väisänen; Arto Valkonen; Juha Tapio Pulkkinen
Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.
Journal of medicinal chemistry 2013;56(3):1064-73.
2012: Tuulia Tynkkynen; Tommi Hassinen; Pasi Soininen; Mika Tiainen; Reino Laatikainen
(1) H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments.
Magnetic resonance in chemistry : MRC 2012;50(9):598-607.
2012: Peter Würtz; Markku J Savolainen; Pasi Soininen; Matti Tarkka; Russell Thomson; Tuulia Tynkkynen; Jorma S Viikari; Mika Ala-Korpela; Antti Jula; Markus Juonala; Mika Kähönen; Antti J Kangas; Pekka J Karhunen; Pekka Kuukasjärvi; Reino Laatikainen; Jari Laurikka; Terho Lehtimäki; Costan G Magnussen; Juho R Raiko; Olli T Raitakari
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis.
European heart journal 2012;33(18):2307-16.
2012: Pekka K Poutiainen; Janne A Ihalainen; Reino Laatikainen; Tuomas Oravilahti; Jorma J Palvimo; Mikael Peräkylä; Juha Tapio Pulkkinen
Design, synthesis, and biological evaluation of nonsteroidal cycloalkane[d]isoxazole-containing androgen receptor modulators.
Journal of medicinal chemistry 2012;55(14):6316-27.
2012: Ville-Petteri Mäkinen; Tomi Peltola; Pasi Soininen; Lena M Thorn; Tuulia Tynkkynen; Mika Ala-Korpela; Carol Forsblom; Antti J Kangas; Kimmo Kaski; Reino Laatikainen; Per-Henrik Groop
Metabolic diversity of progressive kidney disease in 325 patients with type 1 diabetes (the FinnDiane Study).
Journal of proteome research 2012;11(3):1782-90.
2012: Juuso Lehtivarjo; Tommi Hassinen; Reino Laatikainen; Kari Tuppurainen; Mikael Peräkylä
Combining NMR ensembles and molecular dynamics simulations provides more realistic models of protein structures in solution and leads to better chemical shift prediction.
Journal of biomolecular NMR 2012;52(3):257-67.
2012: Johanna Jyrkkärinne; Jenni Küblbeck; Reino Laatikainen; Antti Poso; Juha Tapio Pulkkinen; Paavo Honkakoski; Tuomo Laitinen
Molecular dynamics simulations for human CAR inverse agonists.
Journal of chemical information and modeling 2012;52(2):457-64.
2010: Pekka K Poutiainen; Tuomas A Venäläinen; Mikael Peräkylä; Juha M Matilainen; Sami Väisänen; Paavo Honkakoski; Reino Laatikainen; Juha Tapio Pulkkinen
Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.
Bioorganic & medicinal chemistry 2010;18(10):3437-47.
2010: Mika Tiainen; Hannu Maaheimo; Pasi Soininen; Reino Laatikainen
13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids.
Magnetic resonance in chemistry : MRC 2010;48(2):117-22.
2010: Marko Toivanen; Sanna Huttunen; Jana Duricová; Pasi Soininen; Reino Laatikainen; Vuokko Loimaranta; Sauli Haataja; Jukka Finne; Seppo Lapinjoki; Carina Tikkanen-Kaukanen
Screening of binding activity of Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus suis to berries and juices.
Phytotherapy research : PTR 2010;24 Suppl 1():S95-101.
2009: Juuso Lehtivarjo; Tommi Hassinen; Samuli-Petrus Korhonen; Mikael Peräkylä; Reino Laatikainen
4D prediction of protein (1)H chemical shifts.
Journal of biomolecular NMR 2009;45(4):413-26.
2009: Pasi Soininen; Antti J Kangas; Peter Würtz; Taru Tukiainen; Tuulia Tynkkynen; Reino Laatikainen; Marjo-Riitta Järvelin; Mika Kähönen; Terho Lehtimäki; Jorma Viikari; Olli T Raitakari; Markku Savolainen; Mika Ala-Korpela
High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism.
The Analyst 2009;134(9):1781-5.
2009: Kati Hanhineva; Pasi Soininen; Mikko Anttonen; Harri I Kokko; Ilana Rogachev; Asaph Aharoni; Reino Laatikainen; Sirpa O Kärenlampi
NMR and UPLC-qTOF-MS/MS characterisation of novel phenylethanol derivatives of phenylpropanoid glucosides from the leaves of strawberry (Fragaria x ananassa cv. Jonsok).
Phytochemical analysis : PCA 2009;20(5):353-64.
2009: Tuulia Tynkkynen; Mika Tiainen; Pasi Soininen; Reino Laatikainen
From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions.
Analytica chimica acta 2009;648(1):105-12.
2008: Susanna Repo; Johanna Jyrkkärinne; Juha Tapio Pulkkinen; Reino Laatikainen; Paavo Honkakoski; Mark S Johnson
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
Journal of medicinal chemistry 2008;51(22):7119-31.
2008: Taru Tukiainen; Tuulia Tynkkynen; Ville-Petteri Mäkinen; Pasi Jylänki; Antti Kangas; Johanna Hokkanen; Aki Vehtari; Olli Gröhn; Merja Hallikainen; Hilkka Soininen; Miia Kivipelto; Per-Henrik Groop; Kimmo Kaski; Reino Laatikainen; Pasi Soininen; Tuula Pirttilä; Mika Ala-Korpela
A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.
Biochemical and biophysical research communications 2008;375(3):356-61.
2008: Juha Tapio Pulkkinen; Paavo Honkakoski; Mikael Peräkylä; Istvan Berczi; Reino Laatikainen
Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library.
Journal of medicinal chemistry 2008;51(12):3562-71.
2008: Mika Tiainen; Hannu Maaheimo; Matthias Niemitz; Pasi Soininen; Reino Laatikainen
Spectral analysis of 1H coupled 13C spectra of the amino acids: adaptive spectral library of amino acid 13C isotopomers and positional fractional 13C enrichments.
Magnetic resonance in chemistry : MRC 2008;46(2):125-37.
2007: Teemu Suna; Aino Salminen; Pasi Soininen; Reino Laatikainen; Petri Ingman; Sanna Mäkelä; Markku Savolainen; Minna L Hannuksela; Matti Jauhiainen; Marja-Riitta Taskinen; Kimmo Kaski; Mika Ala-Korpela
1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps.
NMR in biomedicine 2007;20(7):658-72.
2007: Matthias Niemitz; Reino Laatikainen; Shaonong Chen; Robert Kleps; Alan P Kozikowski; Guido F Pauli
Complete (1)H NMR spectral fingerprint of huperzine A.
Magnetic resonance in chemistry : MRC 2007;45(10):878-82.
2007: Pasi Soininen; Katariina Öörni; Hannu Maaheimo; Reino Laatikainen; Petri T Kovanen; Kimmo Kaski; Mika Ala-Korpela
1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins.
Biochemical and biophysical research communications 2007;360(1):290-4.
2007: Mika Ala-Korpela; Niko Lankinen; Aino Salminen; Teemu Suna; Pasi Soininen; Reino Laatikainen; Petri Ingman; Matti Jauhiainen; Marja-Riitta Taskinen; Károly Héberger; Kimmo Kaski
The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent.
Atherosclerosis 2007;190(2):352-8.
2006: Tarja M Malm; Michael Ort; Leena Tähtivaara; Niko Jukarainen; Gundars Goldsteins; Jukka Puoliväli; Antti Nurmi; Raimo Pussinen; Toni Ahtoniemi; Taina-Kaisa Miettinen; Katja Kanninen; Suvi Leskinen; Nina Vartiainen; Juha Yrjänheikki; Reino Laatikainen; Marni E Harris-White; Milla Koistinaho; Sally A Frautschy; Jan Bures; Jari Koistinaho
beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8852-7.
2005: Samuli-Petrus Korhonen; Kari Tuppurainen; Reino Laatikainen; Mikael Peräkylä
Improving the performance of SOMFA by use of standard multivariate methods.
SAR and QSAR in environmental research 2005;16(6):567-79.
2005: Samuli-Petrus Korhonen; Kari Tuppurainen; Reino Laatikainen; Mikael Peräkylä
Comparing the performance of FLUFF-BALL to SEAL-CoMFA with a large diverse estrogen data set: from relevant superpositions to solid predictions.
Journal of chemical information and modeling 2005;45(6):1874-83.
2005: Kaisa M Koistinen; Pasi Soininen; Tuomas A Venäläinen; Jukka Häyrinen; Reino Laatikainen; Mikael Peräkylä; Arja I Tervahauta; Sirpa O Kärenlampi
Birch PR-10c interacts with several biologically important ligands.
Phytochemistry 2005;66(21):2524-33.
2004: Kari Seppänen; Pasi Soininen; Jukka T Salonen; Simo Lötjönen; Reino Laatikainen
Does mercury promote lipid peroxidation? An in vitro study concerning mercury, copper, and iron in peroxidation of low-density lipoprotein.
Biological trace element research 2004;101(2):117-32.
2004: Kari Tuppurainen; Marja Viisas; Mikael Peräkylä; Reino Laatikainen
Ligand intramolecular motions in ligand-protein interaction: ALPHA, a novel dynamic descriptor and a QSAR study with extended steroid benchmark dataset.
Journal of computer-aided molecular design 2004;18(3):175-87.
2003: Samuli-Petrus Korhonen; Kari Tuppurainen; Reino Laatikainen; Mikael Peräkylä
FLUFF-BALL, a template-based grid-independent superposition and QSAR technique: validation using a benchmark steroid data set.
Journal of chemical information and computer sciences 2003;43(6):1780-93.
2002: Susanna M Nieminen; Riikka Kärki; Seppo Auriola; Mika Toivola; Hartmut Laatsch; Reino Laatikainen; Aapo Hyvärinen; Atte von Wright
Isolation and identification of Aspergillus fumigatus mycotoxins on growth medium and some building materials.
Applied and environmental microbiology 2002;68(10):4871-5.
2002: Lauri Kangas; Niina M Saarinen; Marja Mutanen; Markku Ahotupa; Riikka Hirsinummi; Mikko Unkila; Merja Perälä; Pasi Soininen; Reino Laatikainen; Helena Korte; Risto Santti
Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2002;11 Suppl 2():S48-57.
2002: Harri Santa; Markku Ylisirniö; Tommi Hassinen; Reino Laatikainen; Mikael Peräkylä
Stability and amino acid preferences of type VIII reverse turn: the most common turn in peptides?
Protein engineering 2002;15(8):651-7.
2002: Kari Tuppurainen; Marja Viisas; Reino Laatikainen; Mikael Peräkylä
Evaluation of a novel electronic eigenvalue (EEVA) molecular descriptor for QSAR/QSPR studies: validation using a benchmark steroid data set.
Journal of chemical information and computer sciences 2002;42(3):607-13.
2002: Janne T A Saarela; Kari Tuppurainen; Mikael Peräkylä; Harri Santa; Reino Laatikainen
Correlative motions and memory effects in molecular dynamics simulations of molecules: principal components and rescaled range analysis suggest that the motions of native BPTI are more correlated than those of its mutants.
Biophysical chemistry 2002;95(1):49-57.
2001: Helena Hujakka; J Ratilainen; Timo Korjamo; Hilkka Lankinen; Pentti Kuusela; Harri Santa; Reino Laatikainen; Ale Närvänen
Synthesis and antimicrobial activity of the symmetric dimeric form of Temporin A based on 3-N,N-di(3-aminopropyl)amino propanoic acid as the branching unit.
Bioorganic & medicinal chemistry 2001;9(6):1601-7.
2000: Tuula Tennilä; Elena Azhayeva; Jouko Vepsäläinen; Reino Laatikainen; Alex Azhayev; Igor Mikhailopulo
Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1861-84.
2000: Kari Seppänen; M Kantola; Reino Laatikainen; Kristiina Nyyssönen; Veli-Pekka Valkonen; V Kaarlöpp; Jukka T Salonen
Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2000;14(2):84-7.
1999: Harri Santa; Mikael Peräkylä; Reino Laatikainen
Folding of alpha(r)beta and epsilonbeta reverse turns; a nanosecond molecular dynamics simulation of the hexapeptide MSALNT and the octapeptide NMSALNTL in water.
Journal of biomolecular structure & dynamics 1999;16(5):1033-41.
1998: Kari Seppänen; Reino Laatikainen; Jukka T Salonen; M Kantola; S Lötjönen; Mikko Harri; L Nurminen; Jari Kaikkonen; Kristiina Nyyssönen
Mercury-binding capacity of organic and inorganic selenium in rat blood and liver.
Biological trace element research 1998;65(3):197-210.
1998: Willy J Malaisse; Laurence Ladrière; Hassan Jijakli; Reino Laatikainen; Matthias Niemitz; Ingrid Verbruggen; M Biesernans; Rudolph Willem
Metabolism of the dimethyl ester of [2,3-(13)C]succinic acid in rat hepatocytes.
Molecular and cellular biochemistry 1998;189(1-2):137-44.
1998: Harri Santa; Janne T A Saarela; Reino Laatikainen; J Rautianen; Tuomas Virtanen; M Rytkönen; Rauno Mäntyjärvi
A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins.
Journal of protein chemistry 1998;17(7):657-62.
1998: Reino Laatikainen; Janne T A Saarela; Kari Tuppurainen; T Hassinen
Internal motions of native lysozyme are more organized than those of mutants: a principal component analysis of molecular dynamics data.
Biophysical chemistry 1998;73(1-2):1-5.
1997: Elias Hakalehto; Harri Santa; Jouko Vepsäläinen; Reino Laatikainen; Jukka Finne
Identification of a common structural motif in the disordered N-terminal region of bacterial flagellins--evidence for a new class of fibril-forming peptides.
European journal of biochemistry / FEBS 1997;250(1):19-29.
1996: Reino Laatikainen; Matthias Niemitz; Willy J Malaisse; M Biesemans; Rudolph Willem
A computational strategy for the deconvolution of NMR spectra with multiplet structures and constraints: analysis of overlapping 13C-2H multiplets of 13C enriched metabolites from cell suspensions incubated in deuterated media.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;36(3):359-65.
1996: E Priha; Jyrki Liesivuori; Harri Santa; Reino Laatikainen
Reactions of hydrated formaldehyde in nasal mucus.
Chemosphere 1996;32(6):1077-82.
1992: Vesa Kaartinen; T Mononen; Reino Laatikainen; Ilkka Mononen
Substrate specificity and reaction mechanism of human glycoasparaginase. The N-glycosidic linkage of various glycoasparagines is cleaved through a reaction mechanism similar to L-asparaginase.
The Journal of biological chemistry 1992;267(10):6855-8.
1992: Kari Tuppurainen; S Lötjönen; Reino Laatikainen; Terttu Vartiainen
Structural and electronic properties of MX compounds related to TA100 mutagenicity. A semi-empirical molecular orbital QSAR study.
Mutation research 1992;266(2):181-8.
1991: Kari Tuppurainen; S Lötjönen; Reino Laatikainen; Terttu Vartiainen; U Maran; M Strandberg; T Tamm
About the mutagenicity of chlorine-substituted furanones and halopropenals. A QSAR study using molecular orbital indices.
Mutation research 1991;247(1):97-102.
1990: Markku Parviainen; E V Puhakainen; Reino Laatikainen; K Savolainen; J Herranen; R D Barlow
Nicotine metabolites in the urine of smokers.
Journal of chromatography 1990;525(1):193-202.