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Harald Labischinski

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Shasad Sharif; Jiawei Chen; Sung Joon Kim; Harald Labischinski; Jacob Schaefer
Uniformity of glycyl bridge lengths in the mature cell walls of fem mutants of methicillin-resistant Staphylococcus aureus.
William Stubbings; Goh Chee Yong; Pamela Leow; Rainer Endermann; Falicia Goh; Barbara Körber-Irrgang; Michael Kresken; Harald Labischinski
In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.
Heena Patel; Rolf Pokorny; Michael Seiberling; William Stubbings; Andreas Vente; Arne Andresen; Hans-Dietrich Heilmann; Luis Lopez-Lazaro; Harald Labischinski
Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, in healthy volunteers.

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All Publications

2013: Shasad Sharif; Jiawei Chen; Sung Joon Kim; Harald Labischinski; Jacob Schaefer
Uniformity of glycyl bridge lengths in the mature cell walls of fem mutants of methicillin-resistant Staphylococcus aureus.
Journal of bacteriology 2013;195(7):1421-7.
2011: William Stubbings; Goh Chee Yong; Pamela Leow; Rainer Endermann; Falicia Goh; Barbara Körber-Irrgang; Michael Kresken; Harald Labischinski
In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.
Antimicrobial agents and chemotherapy 2011;55(9):4394-7.
2011: Heena Patel; Rolf Pokorny; Michael Seiberling; William Stubbings; Andreas Vente; Arne Andresen; Hans-Dietrich Heilmann; Luis Lopez-Lazaro; Harald Labischinski
Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, in healthy volunteers.
Antimicrobial agents and chemotherapy 2011;55(9):4386-93.
2010: Nadine-C Emrich; Anke Heisig; William Stubbings; Harald Labischinski; Peter Heisig
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.
The Journal of antimicrobial chemotherapy 2010;65(12):2530-3.
2009: Shasad Sharif; Sung Joon Kim; Harald Labischinski; Jacob Schaefer
Characterization of peptidoglycan in fem-deletion mutants of methicillin-resistant Staphylococcus aureus by solid-state NMR.
Biochemistry 2009;48(14):3100-8.
2009: Tina Wecke; Daniela Zühlke; Ulrike Mäder; Sina Jordan; Birgit Voigt; Stefan Pelzer; Harald Labischinski; Georg Homuth; Michael Hecker; Thorsten Mascher
Daptomycin versus Friulimicin B: in-depth profiling of Bacillus subtilis cell envelope stress responses.
Antimicrobial agents and chemotherapy 2009;53(4):1619-23.
2009: William Stubbings; Harald Labischinski
New antibiotics for antibiotic-resistant bacteria.
F1000 biology reports 2009;1():40.
2008: Karin Streker; Tina Schäfer; Christoph Freiberg; Heike Brötz-Oesterhelt; Jörg Hacker; Harald Labischinski; Knut Ohlsen
In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2008;52(12):4470-4.
2008: Harald Labischinski; Helga Ruebsamen-Waigmann
Prospects and challenges in anti-infective research and development: new drugs and approaches.
Current opinion in pharmacology 2008;8(5):519-21.
2007: Kathleen Julian; Klaudia Kosowska-Shick; Cynthia Whitener; Martin Roos; Harald Labischinski; Aileen Rubio; Leslie Parent; Lois M Ednie; Laura M Koeth; Tatiana Bogdanovich; Peter C Appelbaum
Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis.
Antimicrobial agents and chemotherapy 2007;51(9):3445-8.
2006: Berthold Hinzen; Siegfried Raddatz; Holger Paulsen; Thomas Lampe; Andreas Schumacher; Dieter Häbich; Veronika Hellwig; Jordi Benet-Buchholz; Rainer Endermann; Harald Labischinski; Heike Brötz-Oesterhelt
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.
ChemMedChem 2006;1(7):689-93.
2005: Heike Brötz-Oesterhelt; Dieter Beyer; Hein-Peter Kroll; Rainer Endermann; Christoph Ladel; Werner Schroeder; Berthold Hinzen; Siegfried Raddatz; Holger Paulsen; Kerstin Henninger; Julia Elisabeth Bandow; Hans-Georg Sahl; Harald Labischinski
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Nature medicine 2005;11(10):1082-7.
2005: Heike Brötz-Oesterhelt; Julia Elisabeth Bandow; Harald Labischinski
Bacterial proteomics and its role in antibacterial drug discovery.
Mass spectrometry reviews 2005;24(4):549-65.
2005: Karin Streker; Christoph Freiberg; Harald Labischinski; Jörg Hacker; Knut Ohlsen
Staphylococcus aureus NfrA (SA0367) is a flavin mononucleotide-dependent NADPH oxidase involved in oxidative stress response.
Journal of bacteriology 2005;187(7):2249-56.
2004: Christoph Freiberg; Heike Brötz-Oesterhelt; Harald Labischinski
The impact of transcriptome and proteome analyses on antibiotic drug discovery.
Current opinion in microbiology 2004;7(5):451-9.
2004: Christopher J Thomson; Edward Power; Helga Ruebsamen-Waigmann; Harald Labischinski
Antibacterial research and development in the 21(st) Century--an industry perspective of the challenges.
Current opinion in microbiology 2004;7(5):445-50.
2004: Jennifer L Koehl; Arunachalam Muthaiyan; Radheshyam K Jayaswal; Kerstin Ehlert; Harald Labischinski; Brian J Wilkinson
Cell wall composition and decreased autolytic activity and lysostaphin susceptibility of glycopeptide-intermediate Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2004;48(10):3749-57.
2003: Heike Brötz-Oesterhelt; Igor Knezevic; Stephan Bartel; Thomas Lampe; Ute Warnecke-Eberz; Karl Ziegelbauer; Dieter Häbich; Harald Labischinski
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
The Journal of biological chemistry 2003;278(41):39435-42.
2003: Julia Elisabeth Bandow; Heike Brötz; Lars Ingo Ole Leichert; Harald Labischinski; Michael Hecker
Proteomic approach to understanding antibiotic action.
Antimicrobial agents and chemotherapy 2003;47(3):948-55.
2002: Junko Takahashi; Hitoshi Komatsuzawa; Sakuo Yamada; Tetsuya Nishida; Harald Labischinski; Tamaki Fujiwara; Masaru Ohara; Jun-ichi Yamagishi; Motoyuki Sugai
Molecular characterization of an atl null mutant of Staphylococcus aureus.
Microbiology and immunology 2002;46(9):601-12.
2002: Hitoshi Komatsuzawa; Kouji Ohta; Sakuo Yamada; Kerstin Ehlert; Harald Labischinski; Junko Kajimura; Tamaki Fujiwara; Motoyuki Sugai
Increased glycan chain length distribution and decreased susceptibility to moenomycin in a vancomycin-resistant Staphylococcus aureus mutant.
Antimicrobial agents and chemotherapy 2002;46(1):75-81.
2001: Hitoshi Komatsuzawa; Kouji Ohta; Tamaki Fujiwara; GH Choi; Harald Labischinski; Motoyuki Sugai
Cloning and sequencing of the gene, fmtC, which affects oxacillin resistance in methicillin-resistant Staphylococcus aureus.
FEMS microbiology letters 2001;203(1):49-54.
2001: Kyriacos C Nicolaou; Robert Hughes; S Y Cho; Nicolas Winssinger; Harald Labischinski; Rainer Endermann
Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3824-43.
2001: Kyriacos C Nicolaou; S Y Cho; Robert Hughes; Nicolas Winssinger; C Smethurst; Harald Labischinski; Rainer Endermann
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3798-823.
2001: Christoph Freiberg; Bernd Wieland; F Spaltmann; Kerstin Ehlert; Heike Brötz; Harald Labischinski
Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria.
Journal of molecular microbiology and biotechnology 2001;3(3):483-9.
2001: Susan Boyle-Vavra; Harald Labischinski; C C Ebert; Kerstin Ehlert; Robert S Daum
A spectrum of changes occurs in peptidoglycan composition of glycopeptide-intermediate clinical Staphylococcus aureus isolates.
Antimicrobial agents and chemotherapy 2001;45(1):280-7.
2000: B Weber; Kerstin Ehlert; A Diehl; Peter Reichmann; Harald Labischinski; Regine Hakenbeck
The fib locus in Streptococcus pneumoniae is required for peptidoglycan crosslinking and PBP-mediated beta-lactam resistance.
FEMS microbiology letters 2000;188(1):81-5.
1999: Hitoshi Komatsuzawa; Kouji Ohta; Harald Labischinski; Motoyuki Sugai; Hidekazu Suginaka
Characterization of fmtA, a gene that modulates the expression of methicillin resistance in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1999;43(9):2121-5.
1999: Susanne Rohrer; Kerstin Ehlert; M Tschierske; Harald Labischinski; Brigitte Berger-Bächi
The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9351-6.
1998: Hung Ton-That; Harald Labischinski; Brigitte Berger-Bächi; Olaf Schneewind
Anchor structure of staphylococcal surface proteins. III. Role of the FemA, FemB, and FemX factors in anchoring surface proteins to the bacterial cell wall.
The Journal of biological chemistry 1998;273(44):29143-9.
1998: H Hanaki; Harald Labischinski; Y Inaba; N Kondo; H Murakami; Keiichi Hiramatsu
Increase in glutamine-non-amidated muropeptides in the peptidoglycan of vancomycin-resistant Staphylococcus aureus strain Mu50.
The Journal of antimicrobial chemotherapy 1998;42(3):315-20.
1998: Harald Labischinski; Kerstin Ehlert; Bernd Wieland
Novel anti-staphylococcal targets and compounds.
Expert opinion on investigational drugs 1998;7(8):1245-56.
1998: H Hanaki; Kyoko Kuwahara-Arai; Susan Boyle-Vavra; Robert S Daum; Harald Labischinski; Keiichi Hiramatsu
Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50.
The Journal of antimicrobial chemotherapy 1998;42(2):199-209.
1998: Harald Labischinski; Kerstin Ehlert; Brigitte Berger-Bächi
The targeting of factors necessary for expression of methicillin resistance in staphylococci.
The Journal of antimicrobial chemotherapy 1998;41(6):581-4.
1998: H Hanaki; Harald Labischinski; Y Inaba; Keiichi Hiramatsu
[Increase of non-amidated muropeptides in the cell wall of vancomycin-resistant Staphylococcus aureus (VRSA) strain Mu50].
The Japanese journal of antibiotics 1998;51(4):272-80.
1998: H Hanaki; Harald Labischinski; K Sasaki; Kyoko Kuwahara-Arai; Y Inaba; Keiichi Hiramatsu
[Mechanism of vancomycin resistance in MRSA strain Mu50].
The Japanese journal of antibiotics 1998;51(3):237-47.
1997: Kerstin Ehlert; W Schröder; Harald Labischinski
Specificities of FemA and FemB for different glycine residues: FemB cannot substitute for FemA in staphylococcal peptidoglycan pentaglycine side chain formation.
Journal of bacteriology 1997;179(23):7573-6.
1997: E Vasilieva; Harald Labischinski; Brigitte Berger-Bächi
Identification and mapping of new chromosomal sites affecting response to beta-lactams in Staphylococcus aureus.
International journal of antimicrobial agents 1997;8(1):13-21.
1997: A M Strandén; Kerstin Ehlert; Harald Labischinski; Brigitte Berger-Bächi
Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus.
Journal of bacteriology 1997;179(1):9-16.
1996: U Kopp; M Roos; J Wecke; Harald Labischinski
Staphylococcal peptidoglycan interpeptide bridge biosynthesis: a novel antistaphylococcal target?
Microbial drug resistance (Larchmont, N.Y.) 1996;2(1):29-41.
1995: S Johnson; D Krüger; Harald Labischinski
FemA of Staphylococcus aureus: isolation and immunodetection.
FEMS microbiology letters 1995;132(3):221-8.
1993: Boudewijn L M De Jonge; T Sidow; Y S Chang; Harald Labischinski; B Berger-Bachi; Douglas A Gage; Alexander Tomasz
Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
Journal of bacteriology 1993;175(9):2779-82.
1993: Ulrich Seydel; Harald Labischinski; M Kastowsky; Klaus Brandenburg
Phase behavior, supramolecular structure, and molecular conformation of lipopolysaccharide.
Immunobiology 1993;187(3-5):191-211.
1993: U Henze; T Sidow; J Wecke; Harald Labischinski; Brigitte Berger-Bächi
Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus.
Journal of bacteriology 1993;175(6):1612-20.
1992: Harald Labischinski
Consequences of the interaction of beta-lactam antibiotics with penicillin binding proteins from sensitive and resistant Staphylococcus aureus strains.
Medical microbiology and immunology 1992;181(5):241-65.
1991: Harald Labischinski; Dieter Naumann; W Fischer
Small and medium-angle X-ray analysis of bacterial lipoteichoic acid phase structure.
European journal of biochemistry / FEBS 1991;202(3):1269-74.
1991: L Johannsen; Harald Labischinski; James M Krueger
Somnogenic activity of pseudomurein in rabbits.
Infection and immunity 1991;59(7):2502-4.
1991: Heinrich Maidhof; B Reinicke; P Blümel; Brigitte Berger-Bächi; Harald Labischinski
femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains.
Journal of bacteriology 1991;173(11):3507-13.
1991: Dieter Naumann; D Helm; Harald Labischinski
Microbiological characterizations by FT-IR spectroscopy.
Nature 1991;351(6321):81-2.
1991: Harald Labischinski; E W Goodell; A Goodell; M L Hochberg
Direct proof of a "more-than-single-layered" peptidoglycan architecture of Escherichia coli W7: a neutron small-angle scattering study.
Journal of bacteriology 1991;173(2):751-6.
1991: D Helm; Harald Labischinski; G Schallehn; Dieter Naumann
Classification and identification of bacteria by Fourier-transform infrared spectroscopy.
Journal of general microbiology 1991;137(1):69-79.
1990: Ferenc Rozgonyi; H Hahn; Harald Labischinski; P Giesbrecht
A novel labeling procedure of anteiso-fatty acid-containing lipids in staphylococci for investigating the effect of penicillin on lipid release.
FEMS microbiology letters 1990;59(1-2):11-5.
1990: Harald Labischinski; E Vorgel; W Uebach; R P May; H Bradaczek
Architecture of bacterial lipid A in solution. A neutron small-angle scattering study.
European journal of biochemistry / FEBS 1990;190(2):359-63.
1990: T Sidow; L Johannsen; Harald Labischinski
Penicillin-induced changes in the cell wall composition of Staphylococcus aureus before the onset of bacteriolysis.
Archives of microbiology 1990;154(1):73-81.
1989: Heinrich Maidhof; L Johannsen; Harald Labischinski; P Giesbrecht
Onset of penicillin-induced bacteriolysis in staphylococci is cell cycle dependent.
Journal of bacteriology 1989;171(4):2252-7.
1989: Harald Labischinski; Dieter Naumann; C Schultz; S Kusumoto; T Shiba; E T Rietschel; P Giesbrecht
Comparative X-ray and Fourier-transform-infrared investigations of conformational properties of bacterial and synthetic lipid A of Escherichia coli and Salmonella minnesota as well as partial structures and analogues thereof.
European journal of biochemistry / FEBS 1989;179(3):659-65.
1988: F Beise; Harald Labischinski; H Bradaczek
On the relationships between molecular conformation, affinity towards penicillin-binding proteins, and biological activity of penicillin G-sulfoxide.
Zeitschrift für Naturforschung. C, Journal of biosciences 1988;43(9-10):656-64.
1987: B Leps; Harald Labischinski; H Bradaczek
Conformational behavior of the polysaccharide backbone of murein.
Biopolymers 1987;26(8):1391-406.
1987: Dieter Naumann; Harald Labischinski; W Rönspeck; G Barnickel; H Bradaczek
Vibrational spectroscopic analysis of LD-sequential, bacterial cell wall peptides: an IR and Raman study.
Biopolymers 1987;26(6):795-817.
1987: Dieter Naumann; C Schultz; J Born; Harald Labischinski; Klaus Brandenburg; G von Busse; H Brade; Ulrich Seydel
Investigations into the polymorphism of lipid A from lipopolysaccharides of Escherichia coli and Salmonella minnesota by Fourier-transform infrared spectroscopy.
European journal of biochemistry / FEBS 1987;164(1):159-69.
1985: P Giesbrecht; Harald Labischinski; J Wecke
A special morphogenetic wall defect and the subsequent activity of "murosomes" as the very reason for penicillin-induced bacteriolysis in staphylococci.
Archives of microbiology 1985;141(4):315-24.
1985: B Reinicke; P Blümel; Harald Labischinski; P Giesbrecht
Neither an enhancement of autolytic wall degradation nor an inhibition of the incorporation of cell wall material are pre-requisites for penicillin-induced bacteriolysis in staphylococci.
Archives of microbiology 1985;141(4):309-14.
1985: Harald Labischinski; G Barnickel; H Bradaczek; Dieter Naumann; E T Rietschel; P Giesbrecht
High state of order of isolated bacterial lipopolysaccharide and its possible contribution to the permeation barrier property of the outer membrane.
Journal of bacteriology 1985;162(1):9-20.
1985: Harald Labischinski; G Barnickel; Dieter Naumann; P Keller
Conformational and topological aspects of the three-dimensional architecture of bacterial peptidoglycan.
Annales de l'Institut Pasteur. Microbiologie 1985;136A(1):45-50.
1984: B Leps; Harald Labischinski; G Barnickel; H Bradaczek; P Giesbrecht
A new proposal for the primary and secondary structure of the glycan moiety of pseudomurein. Conformational energy calculations on the glycan strands with talosaminuronic acid in 1C conformation and comparison with murein.
European journal of biochemistry / FEBS 1984;144(2):279-86.
1984: Harald Labischinski; P Giesbrecht; E Fischer; G Barnickel; H Bradaczek; J M Frère; C Houssier; Paulette Charlier; Otto Dideberg; J M Ghuysen
Study of the Zn-containing DD-carboxypeptidase of Streptomyces albus G by small-angle X-ray scattering in solution.
European journal of biochemistry / FEBS 1984;138(1):83-7.
1982: Dieter Naumann; G Barnickel; H Bradaczek; Harald Labischinski; P Giesbrecht
Infrared spectroscopy, a tool for probing bacterial peptidoglycan. Potentialities of infrared spectroscopy for cell wall analytical studies and rejection of models based on crystalline chitin.
European journal of biochemistry / FEBS 1982;125(3):505-15.