Fernand Labrie

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Lévesque Marie-Hélène; El-Alfy Mohamed; Cusan Leonello; Labrie Fernand
Androgen receptor as a potential sign of prostate cancer metastasis.
Luu-The Van; Duche Daniel; Ferraris Corinne; Meunier Jean-Roch; Leclaire Jacques; Labrie Fernand
Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin and full thickness model from Episkin.
Samson Mélanie; Labrie Fernand; Luu-The Van
Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line.

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All Publications

2009: Lévesque Marie-Hélène; El-Alfy Mohamed; Cusan Leonello; Labrie Fernand
Androgen receptor as a potential sign of prostate cancer metastasis.
The Prostate 2009;69(15):1704-11.
2009: Luu-The Van; Duche Daniel; Ferraris Corinne; Meunier Jean-Roch; Leclaire Jacques; Labrie Fernand
Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin and full thickness model from Episkin.
The Journal of steroid biochemistry and molecular biology 2009;116(3-5):178-86.
2009: Samson Mélanie; Labrie Fernand; Luu-The Van
Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line.
The Journal of steroid biochemistry and molecular biology 2009;116(3-5):154-9.
2009: Labrie Fernand; Archer David; Bouchard Céline; Fortier Michel; Cusan Leonello; Gomez José-Luis; Girard Ginette; Baron Mira; Ayotte Normand; Moreau Michèle; Dubé Robert; Côté Isabelle; Labrie Claude; Lavoie Lyne; Bérubé René; Bélanger Patrick; Berger Louise; Gilbert Lucy; Martel Céline; Balser John
Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration.
Menopause (New York, N.Y.) 2009;16(5):897-906.
2009: Labrie Fernand; Archer David; Bouchard Céline; Fortier Michel; Cusan Leonello; Gomez José-Luis; Girard Ginette; Baron Mira; Ayotte Normand; Moreau Michèle; Dubé Robert; Côté Isabelle; Labrie Claude; Lavoie Lyne; Berger Louise; Gilbert Lucy; Martel Céline; Balser John
Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy.
Menopause (New York, N.Y.) 2009;16(5):907-22.
2009: Labrie Fernand; Archer David; Bouchard Céline; Fortier Michel; Cusan Leonello; Gomez José-Luis; Girard Ginette; Baron Mira; Ayotte Normand; Moreau Michèle; Dubé Robert; Côté Isabelle; Labrie Claude; Lavoie Lyne; Berger Louise; Gilbert Lucy; Martel Céline; Balser John
Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women.
Menopause (New York, N.Y.) 2009;16(5):923-31.
2009: Tivesten Asa; Vandenput Liesbeth; Labrie Fernand; Karlsson Magnus K; Ljunggren Osten; Mellström Dan; Ohlsson Claes
Low serum testosterone and estradiol predict mortality in elderly men.
The Journal of clinical endocrinology and metabolism 2009;94(7):2482-8.
2009: Forsblad-d'Elia Helena; Carlsten Hans; Labrie Fernand; Konttinen Yrjö T; Ohlsson Claes
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations.
The Journal of clinical endocrinology and metabolism 2009;94(6):2044-51.
2009: Labrie Fernand; Martel Céline
Concurrent hormone and radiation therapy in patients with breast cancer: how does chemotherapy affect treatment?
The lancet oncology 2009;10(5):444-5; author reply 445-6.
2009: Li Zhuo; Luu-The Van; Poisson-Paré David; Ouellet Johanne; Li Songyun; Labrie Fernand; Pelletier Georges
Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization.
Histology and histopathology 2009;24(3):273-82.
2009: Eriksson Anna L; Lorentzon Mattias; Vandenput Liesbeth; Labrie Fernand; Lindersson Marie; Syvänen Ann-Christine; Orwoll Eric S; Cummings Steven R; Zmuda Joseph M; Ljunggren Osten; Karlsson Magnus K; Mellström Dan; Ohlsson Claes
Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men.
The Journal of clinical endocrinology and metabolism 2009;94(3):1033-41.
2009: Ivanga Mahinè; Labrie Yvan; Calvo Ezequiel; Belleau Pascal; Martel Céline; Pelletier Georges; Morissette Jean; Labrie Fernand; Durocher Francine
Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus.
Molecular reproduction and development 2009;76(3):278-88.
2009: Ma Ci; Yoshioka Mayumi; Boivin André; Gan Lin; Takase Yasukazu; Labrie Fernand; St-Amand Jonny
Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo.
The Prostate 2009;69(3):293-316.
2009: Bydal Patrick; Luu-The Van; Labrie Fernand; Poirier Donald
Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.
European journal of medicinal chemistry 2009;44(2):632-44.
2009: Labrie Fernand; Cusan Leonello; Gomez José Luis; Martel Céline; Bérubé René; Bélanger Patrick; Bélanger Alain; Vandenput Liesbeth; Mellström Dan; Ohlsson Claes
Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer.
The Journal of steroid biochemistry and molecular biology 2009;113(1-2):52-6.
2009: Labrie Fernand; Cusan Leonello; Gomez José-Luis; Côté Isabelle; Bérubé René; Bélanger Patrick; Martel Céline; Labrie Claude
Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women.
Menopause (New York, N.Y.) 2009;16(1):30-6.
2008: Zhang Yonghua; Calvo Ezequiel; Martel Céline; Luu-The Van; Labrie Fernand; Tchernof André
Response of the adipose tissue transcriptome to dihydrotestosterone in mice.
Physiological genomics 2008;35(3):254-61.
2008: Mellström Dan; Vandenput Liesbeth; Mallmin Hans; Holmberg Anna H; Lorentzon Mattias; Odén Anders; Johansson Helena; Orwoll Eric S; Labrie Fernand; Karlsson Magnus K; Ljunggren Osten; Ohlsson Claes
Older men with low serum estradiol and high serum SHBG have an increased risk of fractures.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(10):1552-60.
2008: Labrie Fernand; Cusan Leonello; Gomez José Luis; Côté Isabelle; Bérubé René; Bélanger Patrick; Martel Céline; Labrie Claude
Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women.
The Journal of steroid biochemistry and molecular biology 2008;111(3-5):178-94.
2008: Faucher Frédérick; Cantin Line; Luu-The Van; Labrie Fernand; Breton Rock
The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Biochemistry 2008;47(32):8261-70.
2008: Labrie Fernand; Cusan Leonello; Gomez Jose-Luis; Martel Céline; Bérubé René; Bélanger Patrick; Chaussade Véronique; Deloche Claire; Leclaire Jacques
Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA.
The Journal of steroid biochemistry and molecular biology 2008;110(1-2):1-9.
2008: Luu-The Van; Bélanger Alain; Labrie Fernand
Androgen biosynthetic pathways in the human prostate.
Best practice & research. Clinical endocrinology & metabolism 2008;22(2):207-21.
2008: Labrie Fernand
Endocrinology and the prostate. Preface.
Best practice & research. Clinical endocrinology & metabolism 2008;22(2):vii-ix.
2008: Berger Louise; El-Alfy Mohamed; Labrie Fernand
Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat.
The Journal of steroid biochemistry and molecular biology 2008;109(1-2):67-80.
2008: Labrie Fernand; Koutsilieris Michael
The 12th International Congress on Hormonal Steroids and Hormones & Cancer. Preface.
The Journal of steroid biochemistry and molecular biology 2008;108(3-5):179.
2008: Donet Eva; Bayo Pilar; Calvo Ezequiel; Labrie Fernand; Pérez Paloma
Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation.
The Journal of steroid biochemistry and molecular biology 2008;108(1-2):8-16.
2008: Pelletier G; Labrie C; Martel C; Labrie F
Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology.
The Journal of steroid biochemistry and molecular biology 2008;108(1-2):102-8.
2007: Swanson Charlotte; Mellström Dan; Lorentzon Mattias; Vandenput Liesbeth; Jakobsson Jenny; Rane Anders; Karlsson Magnus; Ljunggren Osten; Smith Ulf; Eriksson Anna-Lena; Bélanger Alain; Labrie Fernand; Ohlsson Claes
The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.
The Journal of clinical endocrinology and metabolism 2007;92(12):4878-82.
2007: Vandenput Liesbeth; Mellström Dan; Lorentzon Mattias; Swanson Charlotte; Karlsson Magnus K; Brandberg John; Lönn Lars; Orwoll Eric; Smith Ulf; Labrie Fernand; Ljunggren Osten; Tivesten Asa; Ohlsson Claes
Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men.
The Journal of clinical endocrinology and metabolism 2007;92(11):4130-7.
2007: Cantin Line; Faucher Frédérick; Couture Jean-François; de Jésus-Tran Karine Pereira; Legrand Pierre; Ciobanu Liviu C; Fréchette Yvon; Labrecque Richard; Singh Shankar Mohan; Labrie Fernand; Breton Rock
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
The Journal of biological chemistry 2007;282(42):30910-9.
2007: Luu-The Van; Ferraris Corinne; Duche Daniel; Bélanger Patrick; Leclaire Jacques; Labrie Fernand
Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis.
The Journal of steroid biochemistry and molecular biology 2007;107(1-2):30-6.
2007: Labrie F; Bélanger A; Labrie C; Candas B; Cusan L; Gomez J L
Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women.
The Journal of steroid biochemistry and molecular biology 2007;107(1-2):57-69.
2007: Swanson Charlotte; Lorentzon Mattias; Vandenput Liesbeth; Labrie Fernand; Rane Anders; Jakobsson Jenny; Chouinard Sarah; Bélanger Alain; Ohlsson Claes
Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).
The Journal of clinical endocrinology and metabolism 2007;92(9):3697-704.
2007: Labrie Fernand
Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy.
Nature clinical practice. Endocrinology & metabolism 2007;3(8):584-93.
2007: Labrie Fernand
Multiple intracrine hormonal targets in the prostate: opportunities and challenges.
BJU international 2007;100 Suppl 2():48-51.
2007: Faucher Frédérick; Cantin Line; Pereira de Jésus-Tran Karine; Lemieux Mélanie; Luu-The Van; Labrie Fernand; Breton Rock
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
Journal of molecular biology 2007;369(2):525-40.
2007: Pelletier G; Li S; Luu-The V; Labrie F
Oestrogenic regulation of pro-opiomelanocortin, neuropeptide Y and corticotrophin-releasing hormone mRNAs in mouse hypothalamus.
Journal of neuroendocrinology 2007;19(6):426-31.
2007: Akaza Hideyuki; Labrie Fernand; Namiki Mikio
[A way of thinking of a MAB therapy for local/locally advanced prostate cancer: the theory and recent evaluation]
Gan to kagaku ryoho. Cancer & chemotherapy 2007;34(4):657-69.
2007: Roy Jenny; Breton Rock; Martel Céline; Labrie Fernand; Poirier Donald
Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.
Bioorganic & medicinal chemistry 2007;15(8):3003-18.
2007: Liu Hong; Bellemare Véronique; Labrie Fernand; Luu-The Van
Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family.
The Journal of steroid biochemistry and molecular biology 2007;104(1-2):75-80.
2007: Ivanga Mahinè; Labrie Yvan; Calvo Ezequiel; Belleau Pascal; Martel Céline; Luu-The Van; Morissette Jean; Labrie Fernand; Durocher Francine
Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus.
Physiological genomics 2007;29(1):13-23.
2007: Pelletier G; Luu-The V; Li S; Bujold G; Labrie F
Localization and glucocorticoid regulation of 11beta-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain.
Neuroscience 2007;145(1):110-5.
2007: Takase Y; Luu-The V; Poisson-Paré D; Labrie F; Pelletier G
Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry.
The Prostate 2007;67(4):405-9.
2007: Qiu Wei; Zhou Ming; Mazumdar Mausumi; Azzi Arezki; Ghanmi Dalila; Luu-The Van; Labrie Fernand; Lin Sheng-Xiang
Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.
The Journal of biological chemistry 2007;282(11):8368-79.
2007: Labrie Fernand; Bélanger Alain; Bélanger Patrick; Bérubé René; Martel Céline; Cusan Leonello; Gomez José; Candas Bernard; Chaussade Véronique; Castiel Isabelle; Deloche Claire; Leclaire Jacques
Metabolism of DHEA in postmenopausal women following percutaneous administration.
The Journal of steroid biochemistry and molecular biology 2007;103(2):178-88.
2007: Vandenput Liesbeth; Labrie Fernand; Mellström Dan; Swanson Charlotte; Knutsson Thomas; Peeker Ralph; Ljunggren Osten; Orwoll Eric; Eriksson Anna L; Damber Jan-Erik; Ohlsson Claes
Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(2):220-7.
2007: Levesque Marie-Hélène; El-Alfy Mohamed; Berger Louise; Labrie Fernand; Labrie Claude
Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases.
Urology 2007;69(1):196-201.
2007: Liu Hong; Zheng Shufang; Bellemare Véronique; Pelletier Georges; Labrie Fernand; Luu-The Van
Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey.
BMC biochemistry 2007;8():2.
2006: Faucher Frédérick; Pereira de Jésus-Tran Karine; Cantin Line; Luu-The Van; Labrie Fernand; Breton Rock
Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.
Journal of molecular biology 2006;364(4):747-63.
2006: Eriksson A L; Lorentzon M; Mellström D; Vandenput L; Swanson C; Andersson N; Hammond G L; Jakobsson J; Rane A; Orwoll E S; Ljunggren O; Johnell O; Labrie F; Windahl S H; Ohlsson C
SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.
The Journal of clinical endocrinology and metabolism 2006;91(12):5029-37.
2006: Liby Karen; Rendi Mara; Suh Nanjoo; Royce Darlene B; Risingsong Renee; Williams Charlotte R; Lamph William; Labrie Fernand; Krajewski Stan; Xu Xiaochun; Kim Heetae; Brown Powel; Sporn Michael B
The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5902-9.
2006: Labrie Fernand
[Keyrole of endocrinology in the victory against prostate cancer]
Bulletin du cancer 2006;93(9):949-58.
2006: Takase Yasukazu; Lévesque Marie-Hélène; Luu-The Van; El-Alfy Mohamed; Labrie Fernand; Pelletier Georges
Expression of enzymes involved in estrogen metabolism in human prostate.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006;54(8):911-21.
2006: Labrie Fernand; Luu-The Van; Martel Céline; Chernomoretz Ariel; Calvo Ezequiel; Morissette Jean; Labrie Claude
Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG).
The Journal of steroid biochemistry and molecular biology 2006;100(1-3):52-8.
2006: Labrie F
Future perspectives of selective estrogen receptor modulators used alone and in combination with DHEA.
Endocrine-related cancer 2006;13(2):335-55.
2006: Labrie Fernand; Bélanger Alain; Bélanger Patrick; Bérubé René; Martel Céline; Cusan Leonello; Gomez José; Candas Bernard; Castiel Isabelle; Chaussade Véronique; Deloche Claire; Leclaire Jacques
Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women.
The Journal of steroid biochemistry and molecular biology 2006;99(4-5):182-8.
2006: Pereira de Jésus-Tran Karine; Côté Pierre-Luc; Cantin Line; Blanchet Jonathan; Labrie Fernand; Breton Rock
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein science : a publication of the Protein Society 2006;15(5):987-99.
2006: Lemieux Christian; Gélinas Yves; Lalonde Josée; Labrie Fernand; Richard Denis; Deshaies Yves
Hypocholesterolemic action of the selective estrogen receptor modulator acolbifene in intact and ovariectomized rats with diet-induced hypercholesterolemia.
Metabolism: clinical and experimental 2006;55(5):605-13.
2006: Yoshioka M; Boivin A; Ye P; Labrie F; St-Amand J
Effects of dihydrotestosterone on skeletal muscle transcriptome in mice measured by serial analysis of gene expression.
Journal of molecular endocrinology 2006;36(2):247-59.
2006: Labrie Fernand
Dehydroepiandrosterone, androgens and the mammary gland.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2006;22(3):118-30.
2006: Ngatcha Béatrice Tchédam; Laplante Yannick; Labrie Fernand; Luu-The Van; Poirier Donald
3Beta-alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines.
Molecular and cellular endocrinology 2006;248(1-2):225-32.
2006: Chouinard Sarah; Tessier Mélanie; Vernouillet Gabrielle; Gauthier Sylvain; Labrie Fernand; Barbier Olivier; Bélanger Alain
Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue.
Molecular pharmacology 2006;69(3):908-20.
2006: Candas Bernard; Labrie Fernand; Gomez José Luis; Cusan Leonello; Chevrette Eric; Lévesque Jacques; Brousseau Ghyslain
Relationship among initial serum prostate specific antigen, prostate specific antigen progression and prostate cancer detection at repeat screening visits.
The Journal of urology 2006;175(2):510-6; discussion 516-7.
2006: Luu-The Van; Tremblay Philippe; Labrie Fernand
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):437-43.
2006: Azzi L; El-Alfy M; Labrie F
Gender differences and effects of sex steroids and dehydroepiandrosterone on androgen and oestrogen alpha receptors in mouse sebaceous glands.
The British journal of dermatology 2006;154(1):21-7.
2006: Bellemare Véronique; Labrie Fernand; Luu-The Van
Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.
The Journal of steroid biochemistry and molecular biology 2006;98(1):18-24.
2005: Labrie F; Luu-The V; Bélanger A; Lin S-X; Simard J; Pelletier G; Labrie C
Is dehydroepiandrosterone a hormone?
The Journal of endocrinology 2005;187(2):169-96.
2005: Lemieux C; Phaneuf D; Labrie F; Giguère V; Richard D; Deshaies Y
Estrogen receptor alpha-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene.
International journal of obesity (2005) 2005;29(10):1236-44.
2005: Pelletier Georges; Luu-The Van; Li Songyun; Labrie Fernand
Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(10):1257-71.
2005: Lemieux Christian; Gélinas Yves; Lalonde Josée; Labrie Fernand; Richard Denis; Deshaies Yves
The selective estrogen receptor modulator acolbifene reduces cholesterolemia independently of its anorectic action in control and cholesterol-fed rats.
The Journal of nutrition 2005;135(9):2225-9.
2005: Tchédam Ngatcha Béatrice; Luu-The Van; Labrie Fernand; Poirier Donald
Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship.
Journal of medicinal chemistry 2005;48(16):5257-68.
2005: Berger L; El-Alfy M; Martel C; Labrie F
Effects of dehydroepiandrosterone, Premarin and Acolbifene on histomorphology and sex steroid receptors in the rat vagina.
The Journal of steroid biochemistry and molecular biology 2005;96(2):201-15.
2005: Couture Jean-François; de Jésus-Tran Karine Pereira; Roy Anne-Marie; Cantin Line; Côté Pierre-Luc; Legrand Pierre; Luu-The Van; Labrie Fernand; Breton Rock
Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
Protein science : a publication of the Protein Society 2005;14(6):1485-97.
2005: Pelletier G; Luu-The V; Li S; Labrie F
Localization of type 5 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization.
Cell and tissue research 2005;320(3):393-8.
2005: Lemieux Christian; Gélinas Yves; Lalonde Josée; Labrie Fernand; Cianflone Katherine; Deshaies Yves
Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors.
Journal of lipid research 2005;46(6):1285-94.
2005: Soucy Geneviève; Boivin Guy; Labrie Fernand; Rivest Serge
Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6391-8.
2005: Labrie Fernand; Bélanger Alain; Luu-The Van; Labrie Claude; Simard Jacques; Cusan Leonello; Gomez José; Candas Bernard
Gonadotropin-releasing hormone agonists in the treatment of prostate cancer.
Endocrine reviews 2005;26(3):361-79.
2005: Gauthier Sylvain; Cloutier Julie; Dory Yves L; Favre Alexandre; Mailhot Josée; Ouellet Carl; Schwerdtfeger Annette; Mérand Yves; Martel Céline; Simard Jacques; Labrie Fernand
Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.
Journal of enzyme inhibition and medicinal chemistry 2005;20(2):165-77.
2005: Samson Mélanie; Labrie Fernand; Luu-The Van
Inhibition of human-type 1 3beta-hydroxysteroid deshydrogenase/Delta(5)-Delta(4)-isomerase expression using siRNA.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):253-7.
2005: Luu-The Van; Pelletier Georges; Labrie Fernand
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.
The Journal of steroid biochemistry and molecular biology 2005;93(2-5):269-76.
2005: Labrie Fernand; Luu-The Van; Calvo Ezequiel; Martel Céline; Cloutier Julie; Gauthier Sylvain; Belleau Pascal; Morissette Jean; Lévesque Marie-Hélène; Labrie Claude
Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid.
The Journal of endocrinology 2005;184(2):427-33.
2005: Pelletier G; Luu-The V; Li S; Labrie F
Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies.
The Journal of steroid biochemistry and molecular biology 2005;93(1):49-57.
2005: Azzi Lamia; El-Alfy Mohamed; Martel Céline; Labrie Fernand
Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone.
The Journal of investigative dermatology 2005;124(1):22-7.
2005: Pelletier G; Lihrmann I; Dubessy C; Luu-The V; Vaudry H; Labrie F
Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord.
Neuroscience 2005;132(3):689-96.
2005: Maltais René; Mercier Caroline; Labrie Fernand; Poirier Donald
Solid-phase synthesis of model libraries of 3alpha,17beta-dihydroxy-16alpha-(aminoethyl-N-substituted)-5alpha-androstanes for the development of steroidal therapeutic agents.
Molecular diversity 2005;9(1-3):67-79.
2005: Dinel S; Bolduc C; Belleau P; Boivin A; Yoshioka M; Calvo E; Piedboeuf B; Snyder E E; Labrie F; St-Amand J
Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome.
Nucleic acids research 2005;33(3):e26.
2004: Labrie Fernand; Cusan Leonello; Gomez José; Luu-The Van; Candas Bernard; Bélanger Alain; Labrie Claude
Major impact of hormonal therapy in localized prostate cancer--death can already be an exception.
The Journal of steroid biochemistry and molecular biology 2004;92(5):327-44.
2004: Labrie Fernand
Adrenal androgens and intracrinology.
Seminars in reproductive medicine 2004;22(4):299-309.
2004: Pelletier G; Luu-The V; Li S; Ren L; Labrie F
Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues.
Journal of molecular endocrinology 2004;33(2):459-65.
2004: Bolduc C; Larose M; Yoshioka M; Ye P; Belleau P; Labrie C; Morissette J; Raymond V; Labrie F; St-Amand J
Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression.
Journal of molecular endocrinology 2004;33(2):429-44.
2004: Lépine Johanie; Bernard Olivier; Plante Marie; Têtu Bernard; Pelletier Georges; Labrie Fernand; Bélanger Alain; Guillemette Chantal
Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.
The Journal of clinical endocrinology and metabolism 2004;89(10):5222-32.
2004: Pelletier G; Luu-The V; Li S; Ouellet J; Labrie F
Cellular localization of mRNA expression of enzymes involved in the formation and inactivation of hormonal steroids in the mouse prostate.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(10):1351-6.
2004: Dumont Martine; Frank David; Moisan Anne-Marie; Tranchant Martine; Soucy Penny; Breton Rock; Labrie Fernand; Tavtigian Sean V; Simard Jacques
Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
Biochimica et biophysica acta 2004;1679(3):230-47.
2004: Tchernof André; Labrie Fernand
Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(1):1-14.
2004: Qiu Wei; Zhou Ming; Labrie Fernand; Lin Sheng-Xiang
Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1798-807.
2004: Pelletier G; Luu-The V; Li S; Labrie F
Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.
Brain research. Molecular brain research 2004;125(1-2):143-6.
2004: Larose M; St-Amand J; Yoshioka M; Belleau P; Morissette J; Labrie C; Raymond V; Labrie F
Transcriptome of mouse uterus by serial analysis of gene expression (SAGE): comparison with skeletal muscle.
Molecular reproduction and development 2004;68(2):142-8.
2004: Couture Jean-François; Legrand Pierre; Cantin Line; Labrie Fernand; Luu-The Van; Breton Rock
Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
Journal of molecular biology 2004;339(1):89-102.
2004: Labrie Fernand
Medical castration with LHRH agonists: 25 years later with major benefits achieved on survival in prostate cancer.
Journal of andrology 2004;25(3):305-13.
2004: Labrie Fernand; Candas Bernard; Cusan Lionel; Gomez Jose Luis; Bélanger Alain; Brousseau G; Chevrette Eric; Lévesque Jacques
Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial.
The Prostate 2004;59(3):311-8.
2004: Leblanc Mathias; Bélanger Marie-Claire; Julien Pierre; Tchernof André; Labrie Claude; Bélanger Alain; Labrie Fernand
Plasma lipoprotein profile in the male cynomolgus monkey under normal, hypogonadal, and combined androgen blockade conditions.
The Journal of clinical endocrinology and metabolism 2004;89(4):1849-57.
2004: Labrie Fernand; Champagne Pierre; Labrie Claude; Roy Jean; Laverdière Jacques; Provencher Louise; Potvin Martin; Drolet Yvan; Pollak Michael; Panasci Lawrence; L'Espérance Bernard; Dufresne Jean; Latreille Jean; Robert Jean; Samson Benoît; Jolivet Jacques; Yelle Louise; Cusan Lionel; Diamond Pierre; Candas Bernard
Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(5):864-71.
2004: Labrie Fernand
Current status of endocrine therapy in localized prostate cancer: cure has become a strong possibility.
International braz j urol : official journal of the Brazilian Society of Urology 2004;30(1):3-11.
2003: Akaza Hideyuki; Hirao Yoshihiko; Labrie Fernand; Soloway Mark S
[Future prospects for primary hormone therapy in localized and locally advanced prostate cancer]
Hinyokika kiyo. Acta urologica Japonica 2003;49(12):771-7.
2003: Bélanger Alain; Pelletier Georges; Labrie Fernand; Barbier Olivier; Chouinard Sarah
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans.
Trends in endocrinology and metabolism: TEM 2003;14(10):473-9.
2003: Sullivan David A; Bélanger Alain; Cermak Jennifer M; Bérubé René; Papas Athena S; Sullivan Rose M; Yamagami Hiroko; Dana M Reza; Labrie Fernand
Are women with Sjögren's syndrome androgen-deficient?
The Journal of rheumatology 2003;30(11):2413-9.
2003: Gingras Sébastien; Turgeon Carl; Brochu Nancy; Soucy Penny; Labrie Fernand; Simard Jacques
Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells.
The Journal of steroid biochemistry and molecular biology 2003;87(2-3):167-79.
2003: Pelletier G; Luu-The V; Li S; Ren L; Labrie F
Sex-related expression of 20alpha-hydroxysteroid dehydrogenase mRNA in the adult mouse.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(11):1425-36.
2003: Labrie Fernand; El-Alfy Mohamed; Berger Louise; Labrie Claude; Martel Céline; Bélanger Alain; Candas Bernard; Pelletier Georges
The combination of a novel selective estrogen receptor modulator with an estrogen protects the mammary gland and uterus in a rodent model: the future of postmenopausal women's health?
Endocrinology 2003;144(11):4700-6.
2003: Roy Jenny; Couillard Steeve; Gutman Mathieu; Labrie Fernand
A novel pure SERM achieves complete regression of the majority of human breast cancer tumors in nude mice.
Breast cancer research and treatment 2003;81(3):223-9.
2003: Labrie Fernand; Cusan Leonello; Gomez José Luis; Candas Bernard; Bélanger Alain; Luu-The Van; Labrie Claude; Simard Jacques
[From the gene to the clinic: prostate cancer death can now be an exception?]
Médecine sciences : M/S 2003;19(10):910-9.
2003: Ciobanu Liviu C; Luu-The Van; Martel Céline; Labrie Fernand; Poirier Donald
Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase.
Cancer research 2003;63(19):6442-6.
2003: Leblanc Mathias; Labrie Claude; Bélanger Alain; Candas Bernard; Labrie Fernand
Bioavailability and pharmacokinetics of dehydroepiandrosterone in the cynomolgus monkey.
The Journal of clinical endocrinology and metabolism 2003;88(9):4293-302.
2003: Couture Jean-François; Legrand Pierre; Cantin Line; Luu-The Van; Labrie Fernand; Breton Rock
Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
Journal of molecular biology 2003;331(3):593-604.
2003: Dimitrakakis Constantine; Zhou Jian; Wang Jie; Belanger Alain; LaBrie Fernand; Cheng Clara; Powell Douglas; Bondy Carolyn
A physiologic role for testosterone in limiting estrogenic stimulation of the breast.
Menopause (New York, N.Y.) 2003;10(4):292-8.
2003: Simard J; Dumont M; Labuda D; Sinnett D; Meloche C; El-Alfy M; Berger L; Lees E; Labrie F; Tavtigian S V
Prostate cancer susceptibility genes: lessons learned and challenges posed.
Endocrine-related cancer 2003;10(2):225-59.
2003: Pelletier Georges; Li Songyun; Phaneuf Daniel; Martel Céline; Labrie Fernand
Morphological studies of prolactin-secreting cells in estrogen receptor alpha and estrogen receptor beta knockout mice.
Neuroendocrinology 2003;77(5):324-33.
2003: Labrie F
Extragonadal synthesis of sex steroids: intracrinology.
Annales d'endocrinologie 2003;64(2):95-107.
2003: Labrie Fernand; Luu-The Van; Labrie Claude; Bélanger Alain; Simard Jacques; Lin Sheng-Xiang; Pelletier Georges
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
Endocrine reviews 2003;24(2):152-82.
2003: Jensen Janne; Kitlen Jason W; Briand Per; Labrie Fernand; Lykkesfeldt Anne E
Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium.
The Journal of steroid biochemistry and molecular biology 2003;84(4):469-78.
2003: Lemieux Christian; Picard Frédéric; Labrie Fernand; Richard Denis; Deshaies Yves
The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity.
Obesity research 2003;11(3):477-90.
2003: Tatchum-Talom Rabelais; Martel Céline; Labrie Fernand; Marette André
Acute vascular effects of the selective estrogen receptor modulator EM-652 (SCH 57068) in the rat mesenteric vascular bed.
Cardiovascular research 2003;57(2):535-43.
2003: Gutman Mathieu; Couillard Steeve; Labrie Fernand; Candas Bernard; Labrie Claude
Effect of treatment sequence with radiotherapy and the antiestrogen EM 800 on the growth of ZR 75 1 human mammary carcinoma in nude mice.
International journal of cancer. Journal international du cancer 2003;103(2):268-76.
2002: Labrie Fernand
Androgen blockade in prostate cancer in 2002: major benefits on survival in localized disease.
Molecular and cellular endocrinology 2002;198(1-2):77-87.
2002: Labrie Fernand; Candas Bernard
Interpreting the Quebec prostate cancer study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2002;167(4):340.
2002: Labrie Fernand; Candas Bernard; Gomez Jose-Luis; Cusan Leonello
Can combined androgen blockade provide long-term control or possible cure of localized prostate cancer?
Urology 2002;60(1):115-9.
2002: Leblanc Mathias; Labrie Claude; Bélanger Alain; Candas Bernard; Labrie Fernand
Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey.
The Journal of steroid biochemistry and molecular biology 2002;81(2):159-64.
2002: Simoncini Tommaso; Varone Gaetano; Fornari Letizia; Mannella Paolo; Luisi Michele; Labrie Fernand; Genazzani Andrea R
Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator.
Endocrinology 2002;143(6):2052-61.
2002: Simard Jacques; Dumont Martine; Soucy Penny; Labrie Fernand
Perspective: prostate cancer susceptibility genes.
Endocrinology 2002;143(6):2029-40.
2002: Bernardi Francesca; Stomati Massimo; Luisi Stefano; Pieri Matteo; Labrie Fernand; Riccardo Genazzani Andrea
Effects of the new generation selective estrogen receptor modulator EM-652 and oral administration of estradiol valerate on circulating, brain, and adrenal beta-endorphin and allopregnanolone levels in intact fertile and ovariectomized rats.
Fertility and sterility 2002;77(5):1018-27.
2002: Gutman Matthieu; Couillard Steeve; Roy Jenny; Labrie Fernand; Candas Bernard; Labrie Claude
Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice.
International journal of cancer. Journal international du cancer 2002;99(2):273-8.
2002: Couture Jean François; Cantin Line; Legrand Pierre; Luu-The Van; Labrie Fernand; Breton Rock
Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 1):135-9.
2001: Labrie F; Labrie C; Bélanger A; Simard J; Giguère V; Tremblay A; Tremblay G
EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):213-25.
2001: Pelletier G; El-Alfy M; Labrie C; Martel C; Labrie F
Effect of long-term treatment with the antiestrogen EM-652.HCl on pituitary estrogen receptor alpha and prolactin mRNA expression in intact, ovariectomized and gonadotropin-releasing hormone-treated female rats.
Neuroendocrinology 2001;74(6):367-74.
2001: Pelletier G; Li S; Luu-The V; Tremblay Y; Bélanger A; Labrie F
Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads.
The Journal of endocrinology 2001;171(2):373-83.
2001: Nahoum V; Gangloff A; Legrand P; Zhu D W; Cantin L; Zhorov B S; Luu-The V; Labrie F; Breton R; Lin S X
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
The Journal of biological chemistry 2001;276(45):42091-8.
2001: Pelletier G; Labrie C; Martel C; Li S; Labrie F
Role of extra-ovarian oestrogens in the regulation of gonadotropin releasing hormone mRNA expression in the rat brain.
Journal of neuroendocrinology 2001;13(8):678-82.
2001: Labrie F; Luu-The V; Labrie C; Simard J
DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology.
Frontiers in neuroendocrinology 2001;22(3):185-212.
2001: Zhu D W; Cantin L; Nahoum V; Rehse P; Luu-The V; Labrie F; Breton R; Lin S X
Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3 alpha-hydroxysteroid dehydrogenase at 1.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):589-91.
2001: Barbier O; Albert C; Martineau I; Vallée M; High K; Labrie F; Hum D W; Labrie C; Bélanger A
Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes.
Molecular pharmacology 2001;59(3):636-45.
2001: Pelletier G; Luu-The V; El-Alfy M; Li S; Labrie F
Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland.
Journal of molecular endocrinology 2001;26(1):11-9.
2001: Dufort I; Labrie F; Luu-The V
Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.
The Journal of clinical endocrinology and metabolism 2001;86(2):841-6.
2001: Luu-The V; Dufort I; Pelletier G; Labrie F
Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women.
Molecular and cellular endocrinology 2001;171(1-2):77-82.
2001: Labrie F; Labrie C; Bélanger A; Giguere V; Simard J; Mérand Y; Gauthier S; Luu-The V; Candas B; Martel C; Luo S
Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities.
Advances in protein chemistry 2001;56():293-368.
2000: Labrie F; Luu-The V; Lin S X; Simard J; Labrie C
Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues.
Trends in endocrinology and metabolism: TEM 2000;11(10):421-7.
2000: Boivin R P; Luu-The V; Lachance R; Labrie F; Poirier D
Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.
Journal of medicinal chemistry 2000;43(23):4465-78.
2000: Candas B; Cusan L; Gomez J L; Diamond P; Suburu R E; Lévesque J; Brousseau G; Bélanger A; Labrie F
Evaluation of prostatic specific antigen and digital rectal examination as screening tests for prostate cancer.
The Prostate 2000;45(1):19-35.
2000: Sourla A; Richard V; Labrie F; Labrie C
Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin.
The Journal of endocrinology 2000;166(2):455-62.
2000: Labrie F; Luu-The V; Lin S X; Simard J; Labrie C; El-Alfy M; Pelletier G; Bélanger A
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
Journal of molecular endocrinology 2000;25(1):1-16.
2000: Picard F; Deshaies Y; Lalonde J; Samson P; Labrie C; Bélanger A; Labrie F; Richard D
Effects of the estrogen antagonist EM-652.HCl on energy balance and lipid metabolism in ovariectomized rats.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(7):830-40.
2000: Pelletier G; Labrie C; Labrie F
Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs.
The Journal of endocrinology 2000;165(2):359-70.
2000: Labrie F
Screening and early hormonal treatment of prostate cancer are accumulating strong evidence and support.
The Prostate 2000;43(3):215-22.
2000: Couillard S; Labrie C; Gauthier S; Merand Y; Singh S M; Candas B; Labrie F
Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice.
International journal of cancer. Journal international du cancer 2000;85(3):424-9.
2000: Labrie F; Luu-The V; Labrie C; Pelletier G; El-Alfy M
Intracrinology and the skin.
Hormone research 2000;54(5-6):218-29.
1999: van der Kwast T H; Labrie F; Tetu B
Persistence of high-grade prostatic intra-epithelial neoplasia under combined androgen blockade therapy.
Human pathology 1999;30(12):1503-7.
1999: Boivin R P; Labrie F; Poirier D
17Alpha-alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity.
Steroids 1999;64(12):825-33.
1999: Hida N; Poulin R; Veilleux R; Labrie F
Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells.
The Journal of steroid biochemistry and molecular biology 1999;71(1-2):71-81.
1999: Pelletier G; Luu-The V; Charbonneau A; Labrie F
Cellular localization of estrogen receptor beta messenger ribonucleic acid in cynomolgus monkey reproductive organs.
Biology of reproduction 1999;61(5):1249-55.
1999: Gutman M; Couillard S; Labrie F; Candas B; Labrie C
Effects of the antiestrogen EM-800 (SCH 57050) and cyclophosphamide alone and in combination on growth of human ZR-75-1 breast cancer xenografts in nude mice.
Cancer research 1999;59(20):5176-80.
1999: Couillard S; Gutman M; Labrie F; Candas B; Labrie C
Effect of combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice.
Cancer research 1999;59(19):4857-63.
1999: Zhu D W; Campbell R; Labrie F; Lin S X
Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor.
The Journal of steroid biochemistry and molecular biology 1999;70(4-6):229-35.
1999: Tremblay M R; Luu-The V; Leblanc G; Noël P; Breton E; Labrie F; Poirier D
Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities.
Bioorganic & medicinal chemistry 1999;7(6):1013-23.
1999: Ciobanu L C; Boivin R P; Luu-The V; Labrie F; Poirier D
Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol.
Journal of medicinal chemistry 1999;42(12):2280-6.
1999: Labrie F; Labrie C; Bélanger A; Simard J; Gauthier S; Luu-The V; Mérand Y; Giguere V; Candas B; Luo S; Martel C; Singh S M; Fournier M; Coquet A; Richard V; Charbonneau R; Charpenet G; Tremblay A; Tremblay G; Cusan L; Veilleux R
EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):51-84.
1999: van der Kwast T H; Têtu B; Candas B; Gomez J L; Cusan L; Labrie F
Prolonged neoadjuvant combined androgen blockade leads to a further reduction of prostatic tumor volume: three versus six months of endocrine therapy.
Urology 1999;53(3):523-9.
1999: El-Alfy M; Luu-The V; Huang X F; Berger L; Labrie F; Pelletier G
Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry.
Endocrinology 1999;140(3):1481-91.
1999: Labrie F; Candas B; Dupont A; Cusan L; Gomez J L; Suburu R E; Diamond P; Lévesque J; Belanger A
Screening decreases prostate cancer death: first analysis of the 1988 Quebec prospective randomized controlled trial.
The Prostate 1999;38(2):83-91.
1998: van der Kwast T H; Têtu B; Suburu E R; Gomez J; Lemay M; Labrie F
Cycling activity of benign prostatic epithelial cells during long-term androgen blockade: evidence for self-renewal of luminal cells.
The Journal of pathology 1998;186(4):406-9.
1998: Coquet A; Boudreau N; Merand Y; Labrie F
Validated high-performance liquid chromatographic methods for quantitation of a novel nonsteroidal antiestrogen.
Journal of chromatography. A 1998;828(1-2):247-58.
1998: Chen C; Li X; Singh S M; Labrie F
Activity of 17beta-(N-alkyl/arylformamido) and 17beta-[(N-alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors in the hamster flank organ and ear.
The Journal of investigative dermatology 1998;111(2):273-8.
1998: Pelletier G; Luu-The V; Huang X F; Lapointe H; Labrie F
Localization by in situ hybridization of steroid 5alpha-reductase isozyme gene expression in the human prostate and preputial skin.
The Journal of urology 1998;160(2):577-82.
1998: Labrie F
DHEA as physiological replacement therapy at menopause.
Journal of endocrinological investigation 1998;21(6):399-401.
1998: Martel C; Sourla A; Pelletier G; Labrie C; Fournier M; Picard S; Li S; Stojanovic M; Labrie F
Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat.
The Journal of endocrinology 1998;157(3):433-42.
1998: Luo S; Labrie C; Bélanger A; Candas B; Labrie F
Prevention of development of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat by the new nonsteroidal antiestrogen EM-800 (SCH57050).
Breast cancer research and treatment 1998;49(1):1-11.
1998: Labrie F; Bélanger A; Luu-The V; Labrie C; Simard J; Cusan L; Gomez J L; Candas B
DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging.
Steroids 1998;63(5-6):322-8.
1998: Couillard S; Labrie C; Bélanger A; Candas B; Pouliot F; Labrie F
Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts.
Journal of the National Cancer Institute 1998;90(10):772-8.
1998: Luo S; Sourla A; Labrie C; Gauthier S; Merand Y; Belanger A; Labrie F
Effect of twenty-four-week treatment with the antiestrogen EM-800 on estrogen-sensitive parameters in intact and ovariectomized mice.
Endocrinology 1998;139(5):2645-56.
1998: Martel C; Labrie C; Bélanger A; Gauthier S; Mérand Y; Li X; Provencher L; Candas B; Labrie F
Comparison of the effects of the new orally active antiestrogen EM-800 with ICI 182 780 and toremifene on estrogen-sensitive parameters in the ovariectomized mouse.
Endocrinology 1998;139(5):2486-92.
1998: Turgeon C; Gingras S; Carrière M C; Blais Y; Labrie F; Simard J
Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):151-62.
1998: Martel C; Provencher L; Li X; St Pierre A; Leblanc G; Gauthier S; Mérand Y; Labrie F
Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors.
The Journal of steroid biochemistry and molecular biology 1998;64(3-4):199-205.
1998: Sourla A; Martel C; Labrie C; Labrie F
Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland.
Endocrinology 1998;139(2):753-64.
1998: Couillard S; Gutman M; Labrie C; Bélanger A; Candas B; Labrie F
Comparison of the effects of the antiestrogens EM-800 and tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice.
Cancer research 1998;58(1):60-4.
1998: Couture P; Vohl M C; Gagné C; Gaudet D; Torres A L; Lupien P J; Després J P; Labrie F; Simard J; Moorjani S
Identification of three mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians.
Human mutation 1998;Suppl 1():S226-31.
1997: Luo S; Martel C; Chen C; Labrie C; Candas B; Singh S M; Labrie F
Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity.
Urology 1997;50(6):913-9.
1997: Sourla A; Luo S; Labrie C; Bélanger A; Labrie F
Morphological changes induced by 6-month treatment of intact and ovariectomized mice with tamoxifen and the pure antiestrogen EM-800.
Endocrinology 1997;138(12):5605-17.
1997: Luo S; Martel C; Gauthier S; Mérand Y; Bélanger A; Labrie C; Labrie F
Long-term inhibitory effects of a novel anti-estrogen on the growth of ZR-75-1 and MCF-7 human breast cancer tumors in nude mice.
International journal of cancer. Journal international du cancer 1997;73(5):735-9.
1997: Luo S; Stojanovic M; Labrie C; Labrie F
Inhibitory effect of the novel anti-estrogen EM-800 and medroxyprogesterone acetate on estrone-stimulated growth of dimethylbenz[a]anthracene-induced mammary carcinoma in rats.
International journal of cancer. Journal international du cancer 1997;73(4):580-6.
1997: Luo S; Martel C; Sourla A; Gauthier S; Mérand Y; Belanger A; Labrie C; Labrie F
Comparative effects of 28-day treatment with the new anti-estrogen EM-800 and tamoxifen on estrogen-sensitive parameters in intact mice.
International journal of cancer. Journal international du cancer 1997;73(3):381-91.
1997: Labrie F; Diamond P; Cusan L; Gomez J L; Bélanger A; Candas B
Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women.
The Journal of clinical endocrinology and metabolism 1997;82(10):3498-505.
1997: Luo S; Sourla A; Labrie C; Bélanger A; Labrie F
Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat.
Endocrinology 1997;138(10):4435-44.
1997: Simard J; Labrie C; Bélanger A; Gauthier S; Singh S M; Mérand Y; Labrie F
Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro.
International journal of cancer. Journal international du cancer 1997;73(1):104-12.
1997: Tchernof A; Labrie F; Bélanger A; Prud'homme D; Bouchard C; Tremblay A; Nadeau A; Després J P
Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables.
Atherosclerosis 1997;133(2):235-44.
1997: Simard J; Sanchez R; Poirier D; Gauthier S; Singh S M; Merand Y; Belanger A; Labrie C; Labrie F
Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells.
Cancer research 1997;57(16):3494-7.
1997: Labrie F; Bélanger A; Cusan L; Candas B
Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.
The Journal of clinical endocrinology and metabolism 1997;82(8):2403-9.
1997: Labrie F; Bélanger A; Cusan L; Gomez J L; Candas B
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
The Journal of clinical endocrinology and metabolism 1997;82(8):2396-402.
1997: Luo S; Labrie C; Bélanger A; Labrie F
Effect of dehydroepiandrosterone on bone mass, serum lipids, and dimethylbenz(a)anthracene-induced mammary carcinoma in the rat.
Endocrinology 1997;138(8):3387-94.
1997: Gauthier S; Caron B; Cloutier J; Dory Y L; Favre A; Larouche D; Mailhot J; Ouellet C; Schwerdtfeger A; Leblanc G; Martel C; Simard J; Mérand Y; Bélanger A; Labrie C; Labrie F
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
Journal of medicinal chemistry 1997;40(14):2117-22.
1997: Simard J; Singh S M; Labrie F
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters.
Urology 1997;49(4):580-6; discussion 586-9.
1997: Labrie F; Cusan L; Gomez J L; Diamond P; Suburu R; Lemay M; Tetu B; Fradet Y; Bélanger A; Candas B
Neoadjuvant hormonal therapy: the Canadian experience.
Urology 1997;49(3A Suppl):56-64.
1997: Lourdusamy M; Côté J; Laplante S; Labrie F; Singh S M
Synthesis and in vitro study of 17 beta-[N-ureylene-N,N'-disubstituted]-4-methyl-4-aza-5 alpha-androstan-3-ones as selective inhibitors of type I 5 alpha-reductase.
Bioorganic & medicinal chemistry 1997;5(2):305-10.
1997: Laverdière J; Gomez J L; Cusan L; Suburu E R; Diamond P; Lemay M; Candas B; Fortin A; Labrie F
Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer.
International journal of radiation oncology, biology, physics 1997;37(2):247-52.
1997: Labrie F; Luu-The V; Lin S X; Labrie C; Simard J; Breton R; Bélanger A
The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology.
Steroids 1997;62(1):148-58.
1996: Dufort I; Soucy P; Labrie F; Luu-The V
Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids.
Biochemical and biophysical research communications 1996;228(2):474-9.
1996: Simard J; Durocher F; Mébarki F; Turgeon C; Sanchez R; Labrie Y; Couet J; Trudel C; Rhéaume E; Morel Y; Luu-The V; Labrie F
Molecular biology and genetics of the 3 beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family.
The Journal of endocrinology 1996;150 Suppl():S189-207.
1996: Diamond P; Cusan L; Gomez J L; Bélanger A; Labrie F
Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women.
The Journal of endocrinology 1996;150 Suppl():S43-50.
1996: Lin S X; Zhu D W; Azzi A; Campbell R L; Breton R; Labrie F; Ghosh D; Pletnev V; Duax W L; Pangborn W
Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.
The Journal of endocrinology 1996;150 Suppl():S13-20.
1996: Chen C; Poulin R; Labrie F
Large Shionogi tumors lose their responsiveness to flutamide treatment.
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):489-94.
1996: Blais Y; Zhao C; Huber M; Audette M; Labrie F; Poulin R
Growth-independent induction of spermidine transport by IL-4 and IL-13 in ZR-75-1 human breast cancer cells.
International journal of cancer. Journal international du cancer 1996;67(4):532-8.
1996: Azzi A; Rehse P H; Zhu D W; Campbell R L; Labrie F; Lin S X
Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.
Nature structural biology 1996;3(8):665-8.
1996: Blais Y; Gingras S; Haagensen D E; Labrie F; Simard J
Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells.
Molecular and cellular endocrinology 1996;121(1):11-8.
1996: Puy L A; Turgeon C; Gagné D; Labrie Y; Chen C; Pelletier G; Simard J; Labrie F
Localization and regulation of expression of the FAR-17A gene in the hamster flank organs.
The Journal of investigative dermatology 1996;107(1):44-50.
1996: Durocher F; Shattuck-Eidens D; McClure M; Labrie F; Skolnick M H; Goldgar D E; Simard J
Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations.
Human molecular genetics 1996;5(6):835-42.
1996: Tchernof A; Lamarche B; Prud'Homme D; Nadeau A; Moorjani S; Labrie F; Lupien P J; Després J P
The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men.
Diabetes care 1996;19(6):629-37.
1996: Dufort I; Tremblay Y; Bélanger A; Labrie F; Luu-The V
Isolation and characterization of a stereospecific 3beta-hydroxysteriod sulfotransferase (pregnenolone sulfotransferase) cDNA.
DNA and cell biology 1996;15(6):481-7.
1996: Chen C; Belanger A; Labrie F
Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears.
Endocrinology 1996;137(5):1752-7.
1996: Luu-The V; Bernier F; Dufort I; Labrie F
Molecular biology of steroid sulfotransferases.
Annals of the New York Academy of Sciences 1996;784():137-48.
1996: Van der Kwast T H; Têtu B; Fradet Y; Dupont A; Gomez J; Cusan L; Diamond P; Labrie F
Androgen receptor modulation in benign human prostatic tissue and prostatic adenocarcinoma during neoadjuvant endocrine combination therapy.
The Prostate 1996;28(4):227-31.
1996: Lopez-Solache I; Luu-The V; Séralini G E; Labrie F
Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone.
Biochimica et biophysica acta 1996;1305(3):139-44.
1996: Tavtigian S V; Simard J; Rommens J; Couch F; Shattuck-Eidens D; Neuhausen S; Merajver S; Thorlacius S; Offit K; Stoppa-Lyonnet D; Belanger C; Bell R; Berry S; Bogden R; Chen Q; Davis T; Dumont M; Frye C; Hattier T; Jammulapati S; Janecki T; Jiang P; Kehrer R; Leblanc J F; Mitchell J T; McArthur-Morrison J; Nguyen K; Peng Y; Samson C; Schroeder M; Snyder S C; Steele L; Stringfellow M; Stroup C; Swedlund B; Swense J; Teng D; Thomas A; Tran T; Tranchant M; Weaver-Feldhaus J; Wong A K; Shizuya H; Eyfjord J E; Cannon-Albright L; Tranchant M; Labrie F; Skolnick M H; Weber B; Kamb A; Goldgar D E
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Nature genetics 1996;12(3):333-7.
1996: Labrie F; Candas B; Cusan L; Gomez J L; Diamond P; Suburu R; Lemay M
Diagnosis of advanced or noncurable prostate cancer can be practically eliminated by prostate-specific antigen.
Urology 1996;47(2):212-7.
1996: Laflamme N; Leblanc J F; Mailloux J; Faure N; Labrie F; Simard J
Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients.
The Journal of clinical endocrinology and metabolism 1996;81(1):264-8.
1996: Vailancourt L; Ttu B; Fradet Y; Dupont A; Gomez J; Cusan L; Suburu E R; Diamond P; Candas B; Labrie F
Effect of neoadjuvant endocrine therapy (combined androgen blockade) on normal prostate and prostatic carcinoma. A randomized study.
The American journal of surgical pathology 1996;20(1):86-93.
1996: Morissette J; Durocher F; Leblanc J F; Normand T; Labrie F; Simard J
Genetic linkage mapping of the human steroid 5 alpha-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23-->p22.
Cytogenetics and cell genetics 1996;73(4):304-7.
1995: Pelletier G; Luu-The V; Labrie F
Immunocytochemical localization of type I 17 beta-hydroxysteroid dehydrogenase in the rat brain.
Brain research 1995;704(2):233-39.
1995: Labrie F; Bélanger A; Simard J; Van Luu-The; Labrie C
DHEA and peripheral androgen and estrogen formation: intracinology.
Annals of the New York Academy of Sciences 1995;774():16-28.
1995: Luu-The V; Zhang Y; Poirier D; Labrie F
Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition.
The Journal of steroid biochemistry and molecular biology 1995;55(5-6):581-7.
1995: Guérin S L; Leclerc S; Verreault H; Labrie F; Luu-The V
Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1583-97.
1995: Chen C; Puy L A; Simard J; Li X; Singh S M; Labrie F
Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.
The Journal of investigative dermatology 1995;105(5):678-82.
1995: Labrie Y; Durocher F; Lachance Y; Turgeon C; Simard J; Labrie C; Labrie F
The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species.
DNA and cell biology 1995;14(10):849-61.
1995: Bélanger A; van Halbeek H; Graves H C; Grandbois K; Stamey T A; Huang L; Poppe I; Labrie F
Molecular mass and carbohydrate structure of prostate specific antigen: studies for establishment of an international PSA standard.
The Prostate 1995;27(4):187-97.
1995: Blais Y; Sugimoto K; Carrière M C; Haagensen D E; Labrie F; Simard J
Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1 alpha on apolipoprotein D and GCDFP-15 expression in human breast cancer cells.
International journal of cancer. Journal international du cancer 1995;62(6):732-7.
1995: Mébarki F; Sanchez R; Rhéaume E; Laflamme N; Simard J; Forest M G; Bey-Omar F; David M; Labrie F; Morel Y
Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3 beta-hydroxysteroid dehydrogenase gene.
The Journal of clinical endocrinology and metabolism 1995;80(7):2127-34.
1995: Labrie F; Cusan L; Gomez J L; Diamond P; Candas B
Combination of screening and preoperative endocrine therapy: the potential for an important decrease in prostate cancer mortality.
The Journal of clinical endocrinology and metabolism 1995;80(7):2002-13.
1995: Auger S; Mérand Y; Pelletier J D; Poirier D; Labrie F
Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384.
The Journal of steroid biochemistry and molecular biology 1995;52(6):547-65.
1995: Simard J; Rheaume E; Mebarki F; Sanchez R; New M I; Morel Y; Labrie F
Molecular basis of human 3 beta-hydroxysteroid dehydrogenase deficiency.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):127-38.
1995: Ghosh D; Wawrzak Z; Pletnev V; Erman M; Duax W L; Pangborn W; Zhu D W; Labrie F; Lin S X
Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.
Annals of the New York Academy of Sciences 1995;761():341-3.
1995: Luu-The V; Dufort I; Paquet N; Reimnitz G; Labrie F
Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene.
DNA and cell biology 1995;14(6):511-8.
1995: Sugimoto Y; López-Solache I; Labrie F; Luu-The V
Cations inhibit specifically type I 5 alpha-reductase found in human skin.
The Journal of investigative dermatology 1995;104(5):775-8.
1995: Ghosh D; Pletnev V Z; Zhu D W; Wawrzak Z; Duax W L; Pangborn W; Labrie F; Lin S X
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.
Structure (London, England : 1993) 1995;3(5):503-13.
1995: Li S; Lévesque C; Geng C S; Yan X; Labrie F
Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (E1)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat.
Breast cancer research and treatment 1995;34(2):147-59.
1995: Li X; Singh S M; Côté J; Laplante S; Veilleux R; Labrie F
Synthesis and in vitro evaluation of 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17 beta-carboxamides as 5 alpha-reductase inhibitors and antiandrogens.
Journal of medicinal chemistry 1995;38(9):1456-61.
1995: Tchernof A; Després J P; Bélanger A; Dupont A; Prud'homme D; Moorjani S; Lupien P J; Labrie F
Reduced testosterone and adrenal C19 steroid levels in obese men.
Metabolism: clinical and experimental 1995;44(4):513-9.
1995: Labrie F
Endocrine therapy of prostate cancer: optimal form and timing.
The Journal of clinical endocrinology and metabolism 1995;80(4):1066-71.
1995: Rhéaume E; Sanchez R; Mébarki F; Gagnon E; Carel J C; Chaussain J L; Morel Y; Labrie F; Simard J
Identification and characterization of the G15D mutation found in a male patient with 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) deficiency: alteration of the putative NAD-binding domain of type II 3 beta-HSD.
Biochemistry 1995;34(9):2893-900.
1995: Labrie F; Li S; Labrie C; Lévesque C; Mérand Y
Inhibitory effect of a steroidal antiestrogen (EM-170) on estrone-stimulated growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat.
Breast cancer research and treatment 1995;33(3):237-44.
1995: Li X; Singh S M; Labrie F
Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor.
Journal of medicinal chemistry 1995;38(7):1158-73.
1995: Tchernof A; Després J P; Dupont A; Bélanger A; Nadeau A; Prud'homme D; Moorjani S; Lupien P J; Labrie F
Relation of steroid hormones to glucose tolerance and plasma insulin levels in men. Importance of visceral adipose tissue.
Diabetes care 1995;18(3):292-9.
1995: Shattuck-Eidens D; McClure M; Simard J; Labrie F; Narod S; Couch F; Hoskins K; Weber B; Castilla L; Erdos M
A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.
JAMA : the journal of the American Medical Association 1995;273(7):535-41.
1995: Durocher F; Morissette J; Labrie Y; Labrie F; Simard J
Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2.
Genomics 1995;25(3):724-6.
1995: Séralini G E; Luu-Thé V; Labrie F
Cloning and expression of human tyrosine aminotransferase cDNA.
Biochimica et biophysica acta 1995;1260(1):97-101.
1995: Vohl M C; Couture P; Moorjani S; Torres A L; Gagné C; Després J P; Lupien P J; Labrie F; Simard J
Rapid restriction fragment analysis for screening four point mutations of the low-density lipoprotein receptor gene in French Canadians.
Human mutation 1995;6(3):243-6.
1995: Morissette J; Rhéaume E; Leblanc J F; Luu-The V; Labrie F; Simard J
Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase close to D1S514 and the centromeric D1Z5 locus.
Cytogenetics and cell genetics 1995;69(1-2):59-62.
1995: Labrie F; Cusan L; Gomez J L; Diamond P; Suburu R; Lemay M; Têtu B; Fradet Y; Candas B
Downstaging by combination therapy with flutamide and an LHRH agonist before radical prostatectomy.
Cancer surveys 1995;23():149-56.
1994: Bernier F; Leblanc G; Labrie F; Luu-The V
Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene.
The Journal of biological chemistry 1994;269(45):28200-5.
1994: Blais Y; Sugimoto K; Carriere M C; Haagensen D E; Labrie F; Simard J
Potent stimulatory effect of interleukin-1 alpha on apolipoprotein D and gross cystic disease fluid protein-15 expression in human breast-cancer cells.
International journal of cancer. Journal international du cancer 1994;59(3):400-7.
1994: Sugimoto K; Simard J; Haagensen D E; Labrie F
Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells.
The Journal of steroid biochemistry and molecular biology 1994;51(3-4):167-74.
1994: Bélanger A; Candas B; Dupont A; Cusan L; Diamond P; Gomez J L; Labrie F
Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men.
The Journal of clinical endocrinology and metabolism 1994;79(4):1086-90.
1994: Rhéaume E; Sanchez R; Simard J; Chang Y T; Wang J; Pang S; Labrie F
Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 beta-hydroxysteroid dehydrogenase deficiency.
The Journal of clinical endocrinology and metabolism 1994;79(4):1012-8.
1994: Pelletier G; Luu-The V; Labrie F
Immunocytochemical localization of 5 alpha-reductase in rat brain.
Molecular and cellular neurosciences 1994;5(5):394-9.
1994: Breton R; Yang F; Jin J Z; Li B; Labrie F; Lin S X
Human 17 beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization.
The Journal of steroid biochemistry and molecular biology 1994;50(5-6):275-82.
1994: Pelletier J D; Labrie F; Poirier D
N-butyl, N-methyl, 11-[3',17' beta-(dihydroxy)-1',3',5'(10')-estratrien-16' alpha-yl]-9(R/S)-bromo undecanamide: synthesis and 17 beta-HSD inhibiting, estrogenic and antiestrogenic activities.
Steroids 1994;59(9):536-47.
1994: Simard J; Moorjani S; Vohl M C; Couture P; Torres A L; Gagné C; Després J P; Labrie F; Lupien P J
Detection of a novel mutation (stop 468) in exon 10 of the low-density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians.
Human molecular genetics 1994;3(9):1689-91.
1994: Sanchez R; Mébarki F; Rhéaume E; Laflamme N; Forest M G; Bey-Omard F; David M; Morel Y; Labrie F; Simard J
Functional characterization of the novel L108W and P186L mutations detected in the type II 3 beta-hydroxysteroid dehydrogenase gene of a male pseudohermaphrodite with congenital adrenal hyperplasia.
Human molecular genetics 1994;3(9):1639-45.
1994: Dionne P; Singh S M; Labrie F
1H and 13C nuclear magnetic resonance assignments and stereochemistry of N-n-butyl-N-methyl-11-(16'alpha-chloro-3',17'beta- and 17'alpha-dihydroxyestra-1',3',5'(10')-trien-7'alpha-yl) undecanamide.
Steroids 1994;59(8):493-7.
1994: Martel C; Melner M H; Gagné D; Simard J; Labrie F
Widespread tissue distribution of steroid sulfatase, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD 5 alpha-reductase and aromatase activities in the rhesus monkey.
Molecular and cellular endocrinology 1994;104(1):103-11.
1994: Zhu D W; Lee X; Labrie F; Lin S X
Crystal growth of human estrogenic 17beta-hydroxysteroid dehydrogenase.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):550-5.
1994: Couet J; Martel C; Labrie Y; Luo S; Simard J; Labrie F
Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin.
The Journal of investigative dermatology 1994;103(1):60-4.
1994: Sanchez R; de Launoit Y; Durocher F; Bélanger A; Labrie F; Simard J
Formation and degradation of dihydrotestosterone by recombinant members of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase family.
Molecular and cellular endocrinology 1994;103(1-2):29-38.
1994: Cusan L; Gomez J L; Dupont A; Diamond P; Lemay M; Moore S; Labrie F
Metastatic prostate cancer pulmonary nodules: beneficial effects of combination therapy and subsequent withdrawal of flutamide.
The Prostate 1994;24(5):257-61.
1994: Poirier D; Auger S; Mérand Y; Simard J; Labrie F
Synthesis and antiestrogenic activity of diaryl thioether derivatives.
Journal of medicinal chemistry 1994;37(8):1115-25.
1994: Dupont E; Simard J; Luu-The V; Labrie F; Pelletier G
Localization of 3 beta-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization.
Molecular and cellular neurosciences 1994;5(2):119-23.
1994: Sanchez R; Rhéaume E; Laflamme N; Rosenfield R L; Labrie F; Simard J
Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency.
The Journal of clinical endocrinology and metabolism 1994;78(3):561-7.
1994: Li S; Martel C; Dauvois S; Bélanger A; Labrie F
Effect of estrone on the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in the rat: a model of postmenopausal breast cancer.
Endocrinology 1994;134(3):1352-7.
1994: Koutsilieris M; Dupont A; Gomez J; Cusan L; Suburu R; Diamond P; Labrie F
Stratification of stage D2 prostate cancer patients by a disease aggressiveness score and its use in evaluating disease response and outcome to combination hormonal treatment (GnRH-A plus flutamide).
Anticancer research 1994;14(2B):627-34.
1994: Cusan L; Dupont A; Gomez J L; Tremblay R R; Labrie F
Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial.
Fertility and sterility 1994;61(2):281-7.
1994: Martel C; Gagné D; Couet J; Labrie Y; Simard J; Labrie F
Rapid modulation of ovarian 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat.
Molecular and cellular endocrinology 1994;99(1):63-71.
1994: Bernier F; Lopez Solache I; Labrie F; Luu-The V
Cloning and expression of cDNA encoding human placental estrogen sulfotransferase.
Molecular and cellular endocrinology 1994;99(1):R11-5.
1994: Luu-The V; Sugimoto Y; Puy L; Labrie Y; Lopez Solache I; Singh M; Labrie F
Characterization, expression, and immunohistochemical localization of 5 alpha-reductase in human skin.
The Journal of investigative dermatology 1994;102(2):221-6.
1994: Verreault H; Dufort I; Simard J; Labrie F; Luu-The V
Dinucleotide repeat polymorphisms in the HSD3B2 gene.
Human molecular genetics 1994;3(2):384.
1993: Labrie F
Mechanism of action and pure antiandrogenic properties of flutamide.
Cancer 1993;72(12 Suppl):3816-27.
1993: Labrie F; Dupont A; Cusan L; Gomez J; Diamond P; Koutsilieris M; Suburu R; Fradet Y; Lemay M; Têtu B
Downstaging of localized prostate cancer by neoadjuvant therapy with flutamide and lupron: the first controlled and randomized trial.
Clinical and investigative medicine. Médecine clinique et experimentale 1993;16(6):499-509.
1993: Labrie F; Dupont A; Cusan L; Gomez J L; Diamond P
Major advantages of "early" administration of endocrine combination therapy in advanced prostate cancer.
Clinical and investigative medicine. Médecine clinique et experimentale 1993;16(6):493-8.
1993: Labrie F; Bélanger A; Dupont A; Luu-The V; Simard J; Labrie C
Science behind total androgen blockade: from gene to combination therapy.
Clinical and investigative medicine. Médecine clinique et experimentale 1993;16(6):475-92.
1993: Labrie F; Dupont A; Suburu R; Cusan L; Gomez J L; Koutsilieris M; Diamond P; Emond J; Lemay M; Candas B
Optimized strategy for detection of early stage, curable prostate cancer: role of prescreening with prostate-specific antigen.
Clinical and investigative medicine. Médecine clinique et experimentale 1993;16(6):425-39.
1993: Bélanger A; Rong P M; Liu S; Lavoie L; Labrie F
Characterization and measurement of prostate-specific antigen using monoclonal antibodies.
Clinical and investigative medicine. Médecine clinique et experimentale 1993;16(6):409-14.
1993: Dupont A; Cusan L; Gomez J L; Koutsilieris M; Suburu R; Emond J; Labrie F
Combination therapy with flutamide and the LHRH agonist [D-Trp6, des-Gly-NH(2)10]LHRH ethylamide in stage C prostatic carcinoma.
British journal of urology 1993;72(5 Pt 1):629-34.
1993: Simard J; Couet J; Durocher F; Labrie Y; Sanchez R; Breton N; Turgeon C; Labrie F
Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin.
The Journal of biological chemistry 1993;268(26):19659-68.
1993: Dupont A; Gomez J L; Cusan L; Koutsilieris M; Labrie F
Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy.
The Journal of urology 1993;150(3):908-13.
1993: Dupont E; Labrie F; Luu-The V; Pelletier G
Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in rat testis as studied by immunocytochemistry.
Anatomy and embryology 1993;187(6):583-9.
1993: Normand T; Narod S; Labrie F; Simard J
Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21.
Human molecular genetics 1993;2(4):479-83.
1993: Martel C; Trudel C; Couet J; Labrie C; Bélanger A; Labrie F
Blockade of androstenedione-induced stimulation of androgen-sensitive parameters in the rat prostate by combination of Flutamide and 4-MA.
Molecular and cellular endocrinology 1993;91(1-2):43-9.
1993: Juneau C; Dupont E; Luu-The V; Labrie F; Pelletier G
Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization.
Biology of reproduction 1993;48(2):226-34.
1993: Labrie F; Belanger A; Simard J; Labrie C; Dupont A
Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy.
Cancer 1993;71(3 Suppl):1059-67.
1993: Couture P; Thériault C; Simard J; Labrie F
Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.
Endocrinology 1993;132(1):179-85.
1993: Labrie F; Dupont A; Simard J; Luu-The V; Bélanger A
Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer.
European urology 1993;24 Suppl 2():94-105.
1993: Labrie F; Li S; Bélanger A; Côté J; Mérand Y; Lepage M
Controlled release low dose medroxyprogesterone acetate (MPA) inhibits the development of mammary tumors induced by dimethyl-benz(a) anthracene in the rat.
Breast cancer research and treatment 1993;26(3):253-65.
1992: Couet J; Simard J; Martel C; Trudel C; Labrie Y; Labrie F
Regulation of 3-ketosteroid reductase messenger ribonucleic acid levels and 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase activity in rat liver by sex steroids and pituitary hormones.
Endocrinology 1992;131(6):3034-44.
1992: Dumont M; Luu-The V; Dupont E; Pelletier G; Labrie F
Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin.
The Journal of investigative dermatology 1992;99(4):415-21.
1992: Pelletier G; Dupont E; Simard J; Luu-The V; Bélanger A; Labrie F
Ontogeny and subcellular localization of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) in the human and rat adrenal, ovary and testis.
The Journal of steroid biochemistry and molecular biology 1992;43(5):451-67.
1992: Labrie F; Sugimoto Y; Luu-The V; Simard J; Lachance Y; Bachvarov D; Leblanc G; Durocher F; Paquet N
Structure of human type II 5 alpha-reductase gene.
Endocrinology 1992;131(3):1571-3.
1992: Lin S X; Yang F; Jin J Z; Breton R; Zhu D W; Luu-The V; Labrie F
Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.
The Journal of biological chemistry 1992;267(23):16182-7.
1992: Rhéaume E; Simard J; Morel Y; Mebarki F; Zachmann M; Forest M G; New M I; Labrie F
Congenital adrenal hyperplasia due to point mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene.
Nature genetics 1992;1(4):239-45.
1992: Dupont E; Labrie F; Luu-The V; Pelletier G
Immunocytochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human ovary.
The Journal of clinical endocrinology and metabolism 1992;74(5):994-8.
1992: Gomez J L; Dupont A; Cusan L; Tremblay M; Suburu R; Lemay M; Labrie F
Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients.
The American journal of medicine 1992;92(5):465-70.
1992: Roy R; Dauvois S; Labrie F; Belanger A
Estrogen-stimulated glucuronidation of dihydrotestosterone in MCF-7 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):579-82.
1992: Labrie F; Simard J; Luu-The V; Pelletier G; Bélanger A; Lachance Y; Zhao H F; Labrie C; Breton N; de Launoit Y
Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):421-35.
1992: Pinault S; Têtu B; Gagnon J; Monfette G; Dupont A; Labrie F
Transrectal ultrasound evaluation of local prostate cancer in patients treated with LHRH agonist and in combination with flutamide.
Urology 1992;39(3):254-61.
1992: de Launoit Y; Zhao H F; Bélanger A; Labrie F; Simard J
Expression of liver-specific member of the 3 beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity.
The Journal of biological chemistry 1992;267(7):4513-7.
1992: Simard J; de Launoit Y; Haagensen D E; Labrie F
Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cells.
Endocrinology 1992;130(3):1115-21.
1992: Labrie F; Dupont A; Suburu R; Cusan L; Tremblay M; Gomez J L; Emond J
Serum prostate specific antigen as pre-screening test for prostate cancer.
The Journal of urology 1992;147(3 Pt 2):846-51; discussion 851-2.
1992: Dumont M; Luu-The V; de Launoit Y; Labrie F
Expression of human 17 beta-hydroxysteroid dehydrogenase in mammalian cells.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):605-8.
1992: Martel C; Rhéaume E; Takahashi M; Trudel C; Couët J; Luu-The V; Simard J; Labrie F
Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):597-603.
1992: Lachance Y; Luu-The V; Labrie C; Simard J; Dumont M; de Launoit Y; Guérin S; Leblanc G; Labrie F
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.
The Journal of biological chemistry 1992;267(5):3551.
1992: Labrie C; Martel C; Dufour J M; Lévesque C; Mérand Y; Labrie F
Novel compounds inhibit estrogen formation and action.
Cancer research 1992;52(3):610-5.
1992: de Launoit Y; Simard J; Durocher F; Labrie F
Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase.
Endocrinology 1992;130(1):553-5.
1992: Dupont A; Labrie F; Cusan L; Gomez J L; Tremblay M; Lacourcière Y; Emond J; Monfette G
Combination therapy with flutamide and castration (orchiectomy or LH-RH agonist) in untreated patients with advanced prostate cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1992;124():43-54.
1992: Labrie F; Simard J; de Launoit Y; Poulin R; Thériault C; Dumont M; Dauvois S; Martel C; Li S M
Androgens and breast cancer.
Cancer detection and prevention 1992;16(1):31-8.
1991: Lachance Y; Luu-The V; Verreault H; Dumont M; Rhéaume E; Leblanc G; Labrie F
Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal and gonadal specificity.
DNA and cell biology 1991;10(10):701-11.
1991: Rhéaume E; Sirois I; Labrie F; Simard J
Codon 367 polymorphism of the human type I 3 beta-hydroxysteroid dehydrogenase/isomerase gene (HS5DB3).
Nucleic acids research 1991;19(21):6060.
1991: Dupont E; Rhéaume E; Simard J; Luu-The V; Labrie F; Pelletier G
Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization.
Endocrinology 1991;129(5):2687-92.
1991: Dupont E; Labrie F; Luu-The V; Pelletier G
Localization of 17 beta-hydroxysteroid dehydrogenase throughout gestation in human placenta.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(10):1403-7.
1991: Rhéaume E; Leblanc J F; Lachance Y; Labrie F; Simard J
Detection of frequent BglII polymorphism by polymerase chain reaction and TaqI restriction fragment length polymorphism for 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase at the human HSD beta 3 locus (1p11-p13).
Human genetics 1991;87(6):753-4.
1991: Trudel C; Couët J; Martel C; Labrie C; Labrie F
Regulation of adrenal 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase expression and activity by adrenocorticotropin and corticosterone in the rat.
Endocrinology 1991;129(4):2077-84.
1991: Luu-The V; Takahashi M; de Launoit Y; Dumont M; Lachance Y; Labrie F
Evidence for distinct dehydrogenase and isomerase sites within a single 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein.
Biochemistry 1991;30(36):8861-5.
1991: Labrie F; Simard J; Luu-The V; Trudel C; Martel C; Labrie C; Zhao H F; Rhéaume E; Couet J; Breton N
Expression of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) in adipose tissue.
International journal of obesity 1991;15 Suppl 2():91-9.
1991: Zorilla R; Simard J; Labrie F; Pelletier G
Variations of pre-prosomatostatin MRNA levels in the hypothalamic periventricular nucleus during the rat estrous cycle.
Molecular and cellular neurosciences 1991;2(4):294-8.
1991: Rhéaume E; Lachance Y; Zhao H F; Breton N; Dumont M; de Launoit Y; Trudel C; Luu-The V; Simard J; Labrie F
Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads.
Molecular endocrinology (Baltimore, Md.) 1991;5(8):1147-57.
1991: Simard J; Veilleux R; de Launoit Y; Haagensen D E; Labrie F
Stimulation of apolipoprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells.
Cancer research 1991;51(16):4336-41.
1991: Simard J; de Launoit Y; Labrie F
Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells.
The Journal of biological chemistry 1991;266(23):14842-5.
1991: Moorjani S; Dupont A; Labrie F; De Lignieres B; Cusan L; Dupont P; Mailloux J; Lupien P J
Changes in plasma lipoprotein and apolipoprotein composition in relation to oral versus percutaneous administration of estrogen alone or in cyclic association with utrogestan in menopausal women.
The Journal of clinical endocrinology and metabolism 1991;73(2):373-9.
1991: Labrie C; Trudel C; Li S; Martel C; Couêt J; Labrie F
Combination of an antiandrogen and a 5 alpha-reductase inhibitor: a further step towards total androgen blockade?
Endocrinology 1991;129(1):566-8.
1991: Labrie F
Intracrinology.
Molecular and cellular endocrinology 1991;78(3):C113-8.
1991: Poirier D; Labrie C; Mérand Y; Labrie F
Synthesis and biological activity of 17 alpha-alkynylamide derivatives of estradiol.
The Journal of steroid biochemistry and molecular biology 1991;38(6):759-74.
1991: Dauvois S; Geng C S; Lévesque C; Mérand Y; Labrie F
Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice.
Cancer research 1991;51(12):3131-5.
1991: de Launoit Y; Dauvois S; Dufour M; Simard J; Labrie F
Inhibition of cell cycle kinetics and proliferation by the androgen 5 alpha-dihydrotestosterone and antiestrogen N,n-butyl-N-methyl-11-[16' alpha-chloro-3',17 beta-dihydroxy-estra-1',3',5'-(10')triene-7' alpha-yl] undecanamide in human breast cancer ZR-75-1 cells.
Cancer research 1991;51(11):2797-802.
1991: Levesque C; Merand Y; Dufour J M; Labrie C; Labrie F
Synthesis and biological activity of new halo-steroidal antiestrogens.
Journal of medicinal chemistry 1991;34(5):1624-30.
1991: Dupont E; Luu-The V; Labrie F; Pelletier G
Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in human testis as studied by immunocytochemistry.
Journal of andrology 1991;12(3):161-4.
1991: Marchetti B; Spinola P G; Pelletier G; Labrie F
A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth.
The Journal of steroid biochemistry and molecular biology 1991;38(3):307-20.
1991: Simard J; Melner M H; Breton N; Low K G; Zhao H F; Periman L M; Labrie F
Characterization of macaque 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate.
Molecular and cellular endocrinology 1991;75(2):101-10.
1991: Thériault C; Labrie F
Multiple steroid metabolic pathways in ZR-75-1 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1991;38(2):155-64.
1991: Têtu B; Srigley J R; Boivin J C; Dupont A; Monfette G; Pinault S; Labrie F
Effect of combination endocrine therapy (LHRH agonist and flutamide) on normal prostate and prostatic adenocarcinoma. A histopathologic and immunohistochemical study.
The American journal of surgical pathology 1991;15(2):111-20.
1991: Poulin R; Baker D; Poirier D; Labrie F
Multiple actions of synthetic 'progestins' on the growth of ZR-75-1 human breast cancer cells: an in vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids.
Breast cancer research and treatment 1991;17(3):197-210.
1991: Bélanger A; Brochu M; Lacoste D; Noël C; Labrie F; Dupont A; Cusan L; Caron S; Couture J
Steroid glucuronides: human circulatory levels and formation by LNCaP cells.
The Journal of steroid biochemistry and molecular biology 1991;40(4-6):593-8.
1991: Luu-The V; Takahashi M; Labrie F
Differential inhibition of dehydrogenase and 5-ene----4-ene isomerase activities of purified 3 beta-hydroxysteroid dehydrogenase. Evidence for two distinct sites.
The Journal of steroid biochemistry and molecular biology 1991;40(4-6):545-8.
1990: Labrie F; Dupont A; Cusan L; Gomez J; Emond J; Monfette G
Combination therapy with flutamide and medical (LHRH agonist) or surgical castration in advanced prostate cancer: 7-year clinical experience.
The Journal of steroid biochemistry and molecular biology 1990;37(6):943-50.
1990: Zhao H F; Rheáume E; Trudel C; Couët J; Labrie F; Simard J
Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomerase.
Endocrinology 1990;127(6):3237-9.
1990: Dupont E; Luu-The V; Labrie F; Pelletier G
Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in human adrenal gland performed by immunocytochemistry.
Molecular and cellular endocrinology 1990;74(2):R7-10.
1990: Martel C; Labrie C; Dupont E; Couet J; Trudel C; Rheaume E; Simard J; Luu-The V; Pelletier G; Labrie F
Regulation of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase expression and activity in the hypophysectomized rat ovary: interactions between the stimulatory effect of human chorionic gonadotropin and the luteolytic effect of prolactin.
Endocrinology 1990;127(6):2726-37.
1990: Lachance Y; Luu-The V; Labrie C; Simard J; Dumont M; de Launoit Y; Guérin S; Leblanc G; Labrie F
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.
The Journal of biological chemistry 1990;265(33):20469-75.
1990: Couët J; Martel C; Dupont E; Luu-The V; Sirard M A; Zhao H F; Pelletier G; Labrie F
Changes in 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase messenger ribonucleic acid, activity and protein levels during the estrous cycle in the bovine ovary.
Endocrinology 1990;127(5):2141-8.
1990: Zorrilla R; Simard J; Rhéaume E; Labrie F; Pelletier G
Multihormonal control of pre-pro-somatostatin mRNA levels in the periventricular nucleus of the male and female rat hypothalamus.
Neuroendocrinology 1990;52(5):527-36.
1990: Labrie F; Dupont A; Bélanger A; Lacourcière Y; Béland L; Cusan L; Lachance R
Complete response to combination therapy with an LHRH agonist and flutamide in metastatic male breast cancer: a case report.
Clinical and investigative medicine. Médecine clinique et experimentale 1990;13(5):275-8.
1990: Dauvois S; Simard J; Dumont M; Haagensen D E; Labrie F
Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells.
Molecular and cellular endocrinology 1990;73(2-3):171-8.
1990: Takahashi M; Luu-The V; Labrie F
Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 beta-hydroxysteroid dehydrogenase/5----4-ene-isomerase activity.
The Journal of steroid biochemistry and molecular biology 1990;37(2):231-6.
1990: Dupont E; Zhao H F; Rhéaume E; Simard J; Luu-The V; Labrie F; Pelletier G
Localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in rat gonads and adrenal glands by immunocytochemistry and in situ hybridization.
Endocrinology 1990;127(3):1394-403.
1990: Cusan L; Dupont A; Bélanger A; Tremblay R R; Manhes G; Labrie F
Treatment of hirsutism with the pure antiandrogen flutamide.
Journal of the American Academy of Dermatology 1990;23(3 Pt 1):462-9.
1990: Martel C; Labrie C; Couët J; Dupont E; Trudel C; Luu-The V; Takahashi M; Pelletier G; Labrie F
Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) expression and activity in the rat ovary.
Molecular and cellular endocrinology 1990;72(2):R7-13.
1990: Poirier D; Labrie C; Mérand Y; Labrie F
Derivatives of ethynylestradiol with oxygenated 17 alpha-alkyl side chain: synthesis and biological activity.
Journal of steroid biochemistry 1990;36(1-2):133-42.
1990: Simard J; Dauvois S; Haagensen D E; Lévesque C; Mérand Y; Labrie F
Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer.
Endocrinology 1990;126(6):3223-31.
1990: Dupont E; Luu-The V; Labrie F; Pelletier G
Light microscopic immunocytochemical localization of 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase in the gonads and adrenal glands of the guinea pig.
Endocrinology 1990;126(6):2906-9.
1990: Tong Y; Zhao H F; Labrie F; Pelletier G
Regulation of proopiomelanocortin messenger ribonucleic acid content by sex steroids in the arcuate nucleus of the female rat brain.
Neuroscience letters 1990;112(1):104-8.
1990: Luu-The V; Labrie C; Simard J; Lachance Y; Zhao H F; Couët J; Leblanc G; Labrie F
Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.
Molecular endocrinology (Baltimore, Md.) 1990;4(2):268-75.
1990: Poulin R; Poirier D; Thériault C; Couture J; Bélanger A; Labrie F
Wide spectrum of steroids serving as substrates for the formation of lipoidal derivatives in ZR-75-1 human breast cancer cells.
Journal of steroid biochemistry 1990;35(2):237-47.
1990: Marchetti B; Labrie F
Hormonal regulation of beta-adrenergic receptors in the rat mammary gland during the estrous cycle and lactation: role of sex steroids and prolactin.
Endocrinology 1990;126(1):575-81.
1990: Marchetti B; Fortier M A; Poyet P; Folléa N; Pelletier G; Labrie F
Beta-adrenergic receptors in the rat mammary gland during pregnancy and lactation: characterization, distribution, and coupling to adenylate cyclase.
Endocrinology 1990;126(1):565-74.
1990: Labrie C; Simard J; Zhao H F; Pelletier G; Labrie F
Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate.
Molecular and cellular endocrinology 1990;68(2-3):169-79.
1990: Bélanger A; Labrie F; Angeli A
Unconjugated and glucuronide steroid levels in human breast cyst fluid.
Annals of the New York Academy of Sciences 1990;586():93-100.
1990: Labrie F; Simard J; Poulin R; Hatton A C; Labrie C; Dauvois S; Zhao H F; Petitclerc L; Couët J; Dumont M
Potent antagonism between estrogens and androgens on GCDFP-15 expression and cell growth in the ZR-75-1 human breast cancer cells.
Annals of the New York Academy of Sciences 1990;586():174-87.
1990: Dupont A; Boucher H; Cusan L; Lacourciere Y; Emond J; Labrie F
Octreotide and bromocriptine in patients with stage D2 prostate cancer who relapsed during treatment with flutamide and castration.
European journal of cancer (Oxford, England : 1990) 1990;26(6):770-1.
1990: Labrie F; Poulin R; Simard J; Zhao H F; Labrie C; Dauvois S; Dumont M; Hatton A C; Poirier D; Mérand Y
Interactions between estrogens, androgens, progestins, and glucocorticoids in ZR-75-1 human breast cancer cells.
Annals of the New York Academy of Sciences 1990;595():130-48.
1989: Lacoste D; Dubé D; Bélanger A; Labrie F
Effect of 2-week combination therapy with the luteinizing hormone-releasing hormone (LHRH) agonist [D-Trp6, des-Gly-NH2(10)]LHRH ethylamide and the antiandrogen flutamide on prostate structure and steroid levels in the dog.
Molecular and cellular endocrinology 1989;67(2-3):131-8.
1989: Zhao H F; Simard J; Labrie C; Breton N; Rhéaume E; Luu-The V; Labrie F
Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase.
FEBS letters 1989;259(1):153-7.
1989: Dauvois S; Li S M; Martel C; Labrie F
Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat.
Breast cancer research and treatment 1989;14(3):299-306.
1989: Lacoste D; Dubé D; Trudel C; Bélanger A; Labrie F
Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRh agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide.
Journal of andrology 1989;10(6):456-65.
1989: Lacoste D; Labrie F; Dubé D; Bélanger A; Tice T; Gilley R M; Pledger K L
Reversible inhibition of testicular androgen secretion by 3-, 5- and 6-month controlled-release microsphere formulations of the LH-RH agonist [D-Trp6, des-Gly-NH10(2)] LH-RH ethylamide in the dog.
Journal of steroid biochemistry 1989;33(5):1007-11.
1989: Tong Y A; Zhao H F; Labrie F; Pelletier G
Ontogeny of prolactin mRNA in the rat pituitary gland as evaluated by in situ hybridization.
Molecular and cellular endocrinology 1989;67(1):11-6.
1989: Toranzo D; Dupont E; Simard J; Labrie C; Couet J; Labrie F; Pelletier G
Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1748-56.
1989: Tong Y; Simard J; Labrie C; Zhao H F; Labrie F; Pelletier G
Inhibitory effect of androgen on estrogen-induced prolactin messenger ribonucleic acid accumulation in the male rat anterior pituitary gland.
Endocrinology 1989;125(4):1821-8.
1989: Labrie F; Dupont A; Cusan L; Manhès G; Bergeron N; Lacourcière Y; Pineault S; Bélanger A; Monfette G; Emond J
Combination therapy with castration and flutamide: today's treatment of choice for prostate cancer.
Journal of steroid biochemistry 1989;33(4B):817-21.
1989: Poulin R; Merand Y; Poirier D; Levesque C; Dufour J M; Labrie F
Antiestrogenic properties of keoxifene, trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells.
Breast cancer research and treatment 1989;14(1):65-76.
1989: Luu The V; Lachance Y; Labrie C; Leblanc G; Thomas J L; Strickler R C; Labrie F
Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1310-2.
1989: Lacoste D; Caron S; Bélanger A; Labrie F
Effect of 3-week treatment with [D-Trp6, des-Gly-NH10(2)]LHRH ethylamide, aminoglutethimide, ketoconazole or flutamide alone or in combination on testicular, serum, adrenal and prostatic steroid levels in the dog.
Journal of steroid biochemistry 1989;33(2):233-42.
1989: Poulin R; Dufour J M; Labrie F
Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: antagonism by insulin.
Breast cancer research and treatment 1989;13(3):265-76.
1989: Poulin R; Simard J; Labrie C; Petitclerc L; Dumont M; Lagace L; Labrie F
Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line.
Endocrinology 1989;125(1):392-9.
1989: Marchetti B; Spinola P G; Plante M; Poyet P; Folléa N; Pelletier G; Labrie F
Beta-adrenergic receptors in DMBA-induced rat mammary tumors: correlation with progesterone receptor and tumor growth.
Breast cancer research and treatment 1989;13(3):251-63.
1989: Labrie F; Dupont A; Bélanger A; Cusan L; Brochu M; Turina E; Pinault S; Lacourciere Y; Emond J
Anti-hormone treatment for prostate cancer relapsing after treatment with flutamide and castration. Addition of aminoglutethimide and low dose hydrocortisone to combination therapy.
British journal of urology 1989;63(6):634-8.
1989: Poulin R; Poirier D; Merand Y; Thériault C; Bélanger A; Labrie F
Extensive esterification of adrenal C19-delta 5-sex steroids to long-chain fatty acids in the ZR-75-1 human breast cancer cell line.
The Journal of biological chemistry 1989;264(16):9335-43.
1989: Labrie C; Simard J; Zhao H F; Belanger A; Pelletier G; Labrie F
Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate.
Endocrinology 1989;124(6):2745-54.
1989: Tong Y; Zhao H F; Simard J; Labrie F; Pelletier G
Electron microscopic autoradiographic localization of prolactin mRNA in rat pituitary.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(5):567-71.
1989: Bélanger B; Bélanger A; Labrie F; Dupont A; Cusan L; Monfette G
Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men.
Journal of steroid biochemistry 1989;32(5):695-8.
1989: Dauvois S; Spinola P G; Labrie F
Additive inhibitory effects of bromocryptine (CB-154) and medroxyprogesterone acetate (MPA) on dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the rat.
European journal of cancer & clinical oncology 1989;25(5):891-7.
1989: Simard J; Hatton A C; Labrie C; Dauvois S; Zhao H F; Haagensen D E; Labrie F
Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(4):694-702.
1989: Poulin R; Baker D; Poirier D; Labrie F
Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.
Breast cancer research and treatment 1989;13(2):161-72.
1989: Labrie F; Lacourcière Y; Bélanger A; Monfette G; Bergeron N; Dupont A; Pinault S; Emond J; Manhès G; Cusan L
[Total androgen blockade: an argument in favor]
L'unión médicale du Canada 1989;118(1):5.
1989: Dauvois S; Labrie F
Androstenedione and androst-5-ene-3 beta,17 beta-diol stimulate DMBA-induced rat mammary tumors--role of aromatase.
Breast cancer research and treatment 1989;13(1):61-9.
1989: Labrie F; Dupont A; Cusan L; Manhès G; Bergeron N; Lacourcière Y; Pineault S; Bélanger A; Monfette G; Emond J
Combination therapy with flutamide and castration: its benefits at various stages of prostate cancer.
Progress in clinical and biological research 1989;303():161-7.
1989: Bérubé D; Luu The V; Lachance Y; Gagné R; Labrie F
Assignment of the human 3 beta-hydroxysteroid dehydrogenase gene (HSDB3) to the p13 band of chromosome 1.
Cytogenetics and cell genetics 1989;52(3-4):199-200.
1989: Dumont M; Dauvois S; Simard J; Garcia T; Schachter B; Labrie F
Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone receptor expression in human breast cancer.
Journal of steroid biochemistry 1989;34(1-6):397-402.
1989: Labrie F; Luu-The V; Labrie C; Bérubé D; Couet J; Zhao H F; Gagné R; Simard J
Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17.
Journal of steroid biochemistry 1989;34(1-6):189-97.
1988: Labrie F; Dupont A; Giguere M; Cusan L; Bergeron N; Emond J; Monfette G; Lacourciere Y; Boucher H; Lachance R
Important prognostic value of standardized objective criteria of response in stage D2 prostatic carcinoma.
European journal of cancer & clinical oncology 1988;24(12):1869-78.
1988: Spinola P G; Marchetti B; Mérand Y; Bélanger A; Labrie F
Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat mammary tumors.
Breast cancer research and treatment 1988;12(3):287-96.
1988: Lacoste D; St-Arnaud R; Caron S; Belanger A; Labrie F
The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole.
Journal of steroid biochemistry 1988;31(6):963-70.
1988: Pelletier G; Labrie C; Simard J; Duval M; Martinoli M G; Zhao H; Labrie F
Effects of sex steroids on regulation of the levels of C1 peptide of rat prostatic steroid-binding protein mRNA evaluated by in-situ hybridization.
Journal of molecular endocrinology 1988;1(3):213-23.
1988: Luthy I A; Begin D J; Labrie F
Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture.
Journal of steroid biochemistry 1988;31(5):845-52.
1988: Poulin R; Baker D; Labrie F
Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line.
Breast cancer research and treatment 1988;12(2):213-25.
1988: Hubert J F; Thibault L; Turcotte R; Labrie F
Androgens exert selective effects on protein kinase C induced LH and FSH release in rat anterior pituitary cells in culture.
Neuroendocrinology 1988;48(4):360-6.
1988: Bélanger A; Labrie F; Dupont A; Brochu M; Cusan L
Endocrine effects of combined treatment with an LHRH agonist in association with flutamide in metastatic prostatic carcinoma.
Clinical and investigative medicine. Médecine clinique et experimentale 1988;11(5):321-6.
1988: Labrie F; Veilleux R; Fournier A
Low androgen levels induce the development of androgen-hypersensitive cell clones in Shionogi mouse mammary carcinoma cells in culture.
Journal of the National Cancer Institute 1988;80(14):1138-47.
1988: Luthy I A; Bégin D; Labrie F
Mediation by the androgen receptor of the stimulatory and antiandrogenic actions of 17 beta-estradiol on the growth of androgen-sensitive Shionogi mammary carcinoma cells in culture.
Endocrinology 1988;123(3):1418-24.
1988: Labrie C; Belanger A; Labrie F
Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate.
Endocrinology 1988;123(3):1412-7.
1988: Simard J; Labrie C; Hubert J F; Labrie F
Modulation by sex steroids and [D-Trp6, Des-Gly-NH2(10)]luteinizing hormone (LH)-releasing hormone ethylamide of alpha-subunit and LH beta messenger ribonucleic acid levels in the rat anterior pituitary gland.
Molecular endocrinology (Baltimore, Md.) 1988;2(9):775-84.
1988: Bégin D; Luthy I A; Labrie F
Adrenal precursor C19 steroids are potent stimulators of growth of androgen-sensitive mouse mammary carcinoma Shionogi cells in vitro.
Molecular and cellular endocrinology 1988;58(2-3):213-9.
1988: Labrie F; Veilleux R; Fournier A
Glucocorticoids stimulate the growth of mouse mammary carcinoma Shionogi cells in culture.
Molecular and cellular endocrinology 1988;58(2-3):207-11.
1988: Plante M; Lapointe S; Labrie F
Stimulatory effect of synthetic progestins currently used for the treatment of prostate cancer on growth of the androgen-sensitive Shionogi tumor in mice.
Journal of steroid biochemistry 1988;31(1):61-4.
1988: Marchetti B; Labrie F
Characteristics of flutamide action on prostatic and testicular functions in the rat.
Journal of steroid biochemistry 1988;29(6):691-8.
1988: Hubert J F; Simard J; Gagné B; Barden N; Labrie F
Effect of luteinizing hormone releasing hormone (LHRH) and [D-Trp6, des-Gly-NH2(10)]LHRH ethylamide on alpha-subunit and LH beta messenger ribonucleic acid levels in rat anterior pituitary cells in culture.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):521-7.
1988: Dupont A; Labrie F; Giguere M; Borsanyi J P; Lacourciere Y; Bergeron N; Cusan L; Belanger A; Emond J
Combination therapy with flutamide and [D-Trp6]LHRH ethylamide for stage C prostatic carcinoma.
European journal of cancer & clinical oncology 1988;24(4):659-66.
1988: Labrie F; Dupont A; Giguere M; Borsanyi J P; Lacourciere Y; Monfette G; Emond J; Bergeron N
Benefits of combination therapy with flutamide in patients relapsing after castration.
British journal of urology 1988;61(4):341-6.
1988: Lacoste D; St-Arnaud R; Bélanger A; Labrie F
A pure antiandrogen does not interfere with the LHRH agonist-induced blockade of testicular androgen secretion in the dog.
Molecular and cellular endocrinology 1988;56(1-2):141-7.
1988: Moorjani S; Dupont A; Labrie F; Lupien P J; Gagné C; Brun D; Giguère M; Bélanger A; Cusan L
Changes in plasma lipoproteins during various androgen suppression therapies in men with prostatic carcinoma: effects of orchiectomy, estrogen, and combination treatment with luteinizing hormone-releasing hormone agonist and flutamide.
The Journal of clinical endocrinology and metabolism 1988;66(2):314-22.
1988: Simard J; Vincent A; Duchesne R; Labrie F
Full oestrogenic activity of C19-delta 5 adrenal steroids in rat pituitary lactotrophs and somatotrophs.
Molecular and cellular endocrinology 1988;55(2-3):233-42.
1988: Labrie F; Dupont A; Cusan L; Giguere M; Bergeron N; Borsanyi J P; Lacourciere Y; Belanger A; Emond J; Monfette G
Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in previously untreated patients with clinical stage D2 prostate cancer: today's therapy of choice.
Journal of steroid biochemistry 1988;30(1-6):107-17.
1988: Labrie F; Dupont A; Cusan L; Bélanger A; Giguère M; Labrie C; Lacourcière Y; Monfette G; Emond J
Combination therapy with flutamide and [D-Trp6, des-Gly-NH2(10)]LHRH ethylamide in stage C and D prostate cancer: today's therapy of choice--rationale and 5-year clinical experience.
Progress in clinical and biological research 1988;262():11-63.
1988: Labrie F; Dupont A; Giguère M; Borsanyi J P; Lacourciere Y; Bélanger A; Lachance R; Emond J; Monfette G
Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients with advanced prostate cancer.
Progress in clinical and biological research 1988;260():41-62.
1987: Brochu M; Bélanger A; Dupont A; Cusan L; Labrie F
Effects of flutamide and aminoglutethimide on plasma 5 alpha-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate.
Journal of steroid biochemistry 1987;28(6):619-22.
1987: Labrie F; Dupont A; Belanger A; Lachance R
Flutamide eliminates the risk of disease flare in prostatic cancer patients treated with a luteinizing hormone-releasing hormone agonist.
The Journal of urology 1987;138(4):804-6.
1987: Labrie C; Cusan L; Plante M; Lapointe S; Labrie F
Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer.
Journal of steroid biochemistry 1987;28(4):379-84.
1987: Moorjani S; Dupont A; Labrie F; Lupien P J; Brun D; Gagné C; Giguère M; Bélanger A
Increase in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma.
Metabolism: clinical and experimental 1987;36(3):244-50.
1987: Labrie F; Dupont A; Bélanger A; Cusan L; Giguère M; Lacourcière Y; Luthy I; Bégin D; Labrie C; Simard J
Combination therapy in stage C and D prostatic cancer: rationale and five year clinical experience.
Cancer metastasis reviews 1987;6(4):615-36.
1987: Labrie F; Dupont A; Giguere M; Borsanyi J P; Lacourciere Y; Belanger A; Lachance R; Emond J; Monfette G
Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients.
Journal of steroid biochemistry 1987;27(1-3):525-32.
1987: Labrie F; Giguère V; Meunier H; Simard J; Gossard F; Raymond V
Multiple factors controlling ACTH secretion at the anterior pituitary level.
Annals of the New York Academy of Sciences 1987;512():97-114.
1987: St-Arnaud R; Lachance R; Labrie F
Characteristics of radioimmunoassays for the alpha- and beta-subunits of human luteinizing hormone.
Journal of immunoassay 1987;8(1):97-114.
1986: Labrie F; Dupont A; Giguere M; Borsanyi J P; Belanger A; Lacourciere Y; Emond J; Monfette G
Advantages of the combination therapy in previously untreated and treated patients with advanced prostate cancer.
Journal of steroid biochemistry 1986;25(5B):877-83.
1986: St-Arnaud R; Lachance R; Dupont A; Labrie F
Stimulation of the circulating levels of glycoprotein hormone alpha-subunit after combined administration of a luteinizing hormone-releasing hormone (LHRH) agonist and flutamide in patients with cancer of the prostate.
Clinical and investigative medicine. Médecine clinique et experimentale 1986;9(4):215-21.
1986: St Arnaud R; Lachance R; Dupont A; Labrie F
Serum luteinizing hormone (LH) biological activity in castrated patients with cancer of the prostate receiving a pure antiandrogen and in estrogen-pretreated patients treated with an LH-releasing hormone agonist and antiandrogen.
The Journal of clinical endocrinology and metabolism 1986;63(2):297-302.
1986: Lacourcière Y; Dupont A; Giguère M; Labrie F
[Use of bone scintigraphy in the evaluation of bone involvement by prostatic cancer treated with a LHRH-antiandrogen combination]
L'unión médicale du Canada 1986;115(4):229-34.
1986: Labrie F; Dupont A; Bélanger A; St-Arnaud R; Giguère M; Lacourcière Y; Emond J; Monfette G
Treatment of prostate cancer with gonadotropin-releasing hormone agonists.
Endocrine reviews 1986;7(1):67-74.
1986: St-Arnaud R; Lachance R; Kelly S J; Belanger A; Dupont A; Labrie F
Loss of luteinizing hormone bioactivity in patients with prostatic cancer treated with an LHRH agonist and a pure antiandrogen.
Clinical endocrinology 1986;24(1):21-30.
1986: Spinola P G; Marchetti B; Labrie F
Adrenal steroids stimulate growth and progesterone receptor levels in rat uterus and DMBA-induced mammary tumors.
Breast cancer research and treatment 1986;8(3):241-8.
1986: Labrie F; Dupont A; Bélanger A; Lacourcière Y; Monfette J E; Monfette G
[Combined anti-androgen treatment in adenocarcinoma of the prostate: first use of a new therapeutically efficacious principle in hormone-dependent cancer]
Annales d'urologie 1986;20(2):98-106.
1985: Labrie F; Dupont A; Belanger A; Giguere M; Lacoursiere Y; Emond J; Monfette G; Bergeron V
Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival.
Journal of steroid biochemistry 1985;23(5B):833-41.
1985: Labrie F; Dupont A; Belanger A; Lachance R; Giguere M
Long term treatment with luteinising hormone releasing hormone agonists and maintenance of serum testosterone to castration concentrations.
British medical journal (Clinical research ed.) 1985;291(6492):369-70.
1983: Labrie F; Dupont A; Belanger A; Lefebvre F A; Cusan L; Monfette G; Laberge J G; Emond J P; Raynaud J P; Husson J M; Fazekas A T
New hormonal treatment in cancer of the prostate: combined administration of an LHRH agonist and an antiandrogen.
Journal of steroid biochemistry 1983;19(1C):999-1007.
1983: Labrie F; Dupont A; Belanger A; Lacoursiere Y; Raynaud J P; Husson J M; Gareau J; Fazekas A T; Sandow J; Monfette G
New approach in the treatment of prostate cancer: complete instead of partial withdrawal of androgens.
The Prostate 1983;4(6):579-94.
1983: Labrie F; Dupont A; Belanger A; Lefebvre F A; Cusan L; Raynaud J P; Husson J M; Fazekas A T
New hormonal therapy in prostate cancer: combined use of a pure antiandrogen and an LHRH agonist.
Hormone research 1983;18(1-3):18-27.
1982: Di Paolo T; Gagné B; Poyet P; Labrie F
[3H]Apomorphine binding to a GTP-sensitive dopaminergic site in bovine anterior pituitary gland.
Canadian journal of biochemistry 1982;60(11):1043-9.
1982: Giguère V; Meunier H; Veilleux R; Labrie F
Direct effects of sex steroids on prolactin release at the anterior pituitary level: interactions with dopamine, thyrotropin-releasing hormone, and isobutylmethylxanthine.
Endocrinology 1982;111(3):857-62.
1982: Labrie F; Dupont A; Belanger A; Cusan L; Lacourciere Y; Monfette G; Laberge J G; Emond J P; Fazekas A T; Raynaud J P; Husson J M
New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen.
Clinical and investigative medicine. Médecine clinique et experimentale 1982;5(4):267-75.
1981: Raymond V; Lépine J; Lissitzky J C; Côté J; Labrie F
[Control of the parallel release of ACTH, beta-endorphin + beta-LPH and their fragments in cultured adenohypophyseal rat cells]
L'unión médicale du Canada 1981;110(7):635-9, 674.
1981: Raymond V; Lépine J; Giguère V; Lissitzky J C; Côté J; Labrie F
Parallel stimulation of ACTH, beta-LPH + beta-endorphin and alpha-MSH release by alpha-adrenergic agents in rat anterior pituitary cells in culture.
Molecular and cellular endocrinology 1981;22(3):295-303.

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