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John Ladbury
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13
O'Brien, Ronan
13
Williams, Mark
7
Prodromou, Chrisostomos
7
Sturtevant, Julian
7
Cliff, Matthew
6
Ababou, Abdessamad
6
Ahmed, Zamal
6
Pearl, Laurence
6
Renzoni, D
5
Roe, Mark
5
Piper, Peter
5
Driscoll, Paul
4
Haq, Ihtshamul
4
Henriques, DA
4
Lemmon, Mark
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All Publications
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2010: Ahmed Zamal; George Roger; Lin Chi-Chuan; Suen Kin Man; Levitt James A; Suhling Klaus; Ladbury John E
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.
Cellular signalling 2010;22(1):23-33.
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2009: Nilapwar Sanjay; Williams Eleanor; Fu Christopher; Prodromou Christosmos; Pearl Laurence H; Williams Mark A; Ladbury John E
Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.
Journal of molecular biology 2009;392(4):923-36.
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2009: Leonard Paul G; Ono Shusuke; Gor Jayesh; Perkins Stephen J; Ladbury John E
Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.
Molecular microbiology 2009;73(2):165-79.
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2009: Ababou Abdessamad; Pfuhl Mark; Ladbury John E
Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.
Journal of molecular biology 2009;387(5):1120-36.
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2009: George R; Chan H-L; Ahmed Z; Suen K M; Stevens C N; Levitt J A; Suhling K; Timms J; Ladbury J E
A complex of Shc and Ran-GTPase localises to the cell nucleus.
Cellular and molecular life sciences : CMLS 2009;66(4):711-20.
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2009: Zhou Lihong; Li Jiejin; George Roger; Ruchaud Sandrine; Zhou Hong-Gang; Ladbury John E; Earnshaw William C; Yuan Xuemei
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.
Biochemistry 2009;48(6):1156-61.
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2008: Olsson Tjelvar S G; Williams Mark A; Pitt William R; Ladbury John E
The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.
Journal of molecular biology 2008;384(4):1002-17.
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2008: Schüller Annika C; Ahmed Zamal; Levitt James A; Suen Kin M; Suhling Klaus; Ladbury John E
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).
The Biochemical journal 2008;416(2):189-99.
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2008: Taylor Jonathan D; Ababou Abdessamad; Fawaz Radwan R; Hobbs Christopher J; Williams Mark A; Ladbury John E
Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design.
Proteins 2008;73(4):929-40.
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2008: Ababou Abdessamad; Pfuhl Mark; Ladbury John E
The binding stoichiometry of CIN85 SH3 domain A and cbl-b.
Nature structural & molecular biology 2008;15(9):890-1; author reply 891-2.
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2008: Patel Seema; George Roger; Autore Flavia; Fraternali Franca; Ladbury John E; Nikolova Penka V
Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.
Nucleic acids research 2008;36(16):5139-51.
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2008: Ahmed Zamal; Schüller Annika C; Suhling Klaus; Tregidgo Carolyn; Ladbury John E
Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.
The Biochemical journal 2008;413(1):37-49.
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2008: George Roger; Schuller Annika C; Harris Richard; Ladbury John E
A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.
Journal of molecular biology 2008;377(3):740-7.
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2008: Schüller Annika C; Ahmed Zamal; Ladbury John E
Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation.
The Biochemical journal 2008;410(1):205-11.
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2007: Taylor Jonathan D; Gilbert Philip J; Williams Mark A; Pitt William R; Ladbury John E
Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.
Proteins 2007;67(4):981-90.
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2007: Impagliazzo Antonietta; Blok Anneloes J; Cliff Matthew J; Ladbury John E; Ubbink Marcellus
Redox-state-dependent complex formation between pseudoazurin and nitrite reductase.
Journal of the American Chemical Society 2007;129(1):226-33.
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2007: Ladbury John E
Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 1):26-31.
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2007: Ababou Adessamad; Ladbury John E
Survey of the year 2005: literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2007;20(1):4-14.
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2006: Evans Edward J; Castro Mónica A A; O'Brien Ronan; Kearney Alice; Walsh Heather; Sparks Lisa M; Tucknott Michael G; Davies Elizabeth A; Carmo Alexandre M; van der Merwe P Anton; Stuart David I; Jones E Yvonne; Ladbury John E; Ikemizu Shinji; Davis Simon J
Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
The Journal of biological chemistry 2006;281(39):29309-20.
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2006: Beuron Fabienne; Dreveny Ingrid; Yuan Xuemei; Pye Valerie E; McKeown Ciaran; Briggs Louise C; Cliff Matthew J; Kaneko Yayoi; Wallis Russell; Isaacson Rivka L; Ladbury John E; Matthews Steve J; Kondo Hisao; Zhang Xiaodong; Freemont Paul S
Conformational changes in the AAA ATPase p97-p47 adaptor complex.
The EMBO journal 2006;25(9):1967-76.
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2006: Cliff Matthew J; Harris Richard; Barford David; Ladbury John E; Williams Mark A
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
Structure (London, England : 1993) 2006;14(3):415-26.
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2006: Grunau Alex; Paine Mark J; Ladbury John E; Gutierrez Aldo
Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.
Biochemistry 2006;45(5):1421-34.
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2006: Ababou Abdessamad; Ladbury John E
Survey of the year 2004: literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2006;19(1):79-89.
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2006: Zavaleta Jose; Chinchilla Dinora B; Kaddis Catherine F; Martinez Karla; Brown Abby; Gomez Alvaro; Pao Amaris; Ramirez Alejandra; Nilapwar Sanjay; Ladbury John E; Gomez Frank A
Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.
Journal of capillary electrophoresis and microchip technology 2006;9(5-6):101-17.
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2005: Ahmed Zamal; Beeton Carolyn A; Williams Mark A; Clements Darran; Baldari Cosima T; Ladbury John E
Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.
Journal of molecular biology 2005;353(5):1001-10.
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2005: Ono Shusuke; Goldberg Martin D; Olsson Tjelvar; Esposito Diego; Hinton Jay C D; Ladbury John E
H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.
The Biochemical journal 2005;391(Pt 2):203-13.
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2005: Taylor Jonathan D; Fawaz Radwan R; Ababou Abdessamad; Williams Mark A; Ladbury John E
NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src.
Journal of biomolecular NMR 2005;32(4):339.
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2005: Cliff Matthew J; Williams Mark A; Brooke-Smith John; Barford David; Ladbury John E
Molecular recognition via coupled folding and binding in a TPR domain.
Journal of molecular biology 2005;346(3):717-32.
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2005: Yang Jing; Roe S Mark; Cliff Matthew J; Williams Mark A; Ladbury John E; Cohen Patricia T W; Barford David
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
The EMBO journal 2005;24(1):1-10.
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2004: Ladbury John E
Application of isothermal titration calorimetry in the biological sciences: things are heating up!
BioTechniques 2004;37(6):885-7.
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2004: Lachenmann Marcel J; Ladbury John E; Qian Xiuqi; Huang Kun; Singh Rupinder; Weiss Michael A
Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice.
Protein science : a publication of the Protein Society 2004;13(12):3115-26.
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2004: Lachenmann Marcel J; Ladbury John E; Dong Jian; Huang Kun; Carey Paul; Weiss Michael A
Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.
Biochemistry 2004;43(44):13910-25.
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2004: Cliff Matthew J; Gutierrez Aldo; Ladbury John E
A survey of the year 2003 literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2004;17(6):513-23.
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2004: Ladbury John E; Williams Mark A
The extended interface: measuring non-local effects in biomolecular interactions.
Current opinion in structural biology 2004;14(5):562-9.
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2004: Bergqvist Simon; Williams Mark A; O'Brien Ronan; Ladbury John E
Heat capacity effects of water molecules and ions at a protein-DNA interface.
Journal of molecular biology 2004;336(4):829-42.
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2003: Cliff Matthew J; Ladbury John E
A survey of the year 2002 literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2003;16(6):383-91.
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2003: Kowanetz Katarzyna; Szymkiewicz Iwona; Haglund Kaisa; Kowanetz Marcin; Husnjak Koraljka; Taylor Jonathan D; Soubeyran Philippe; Engstrom Ulla; Ladbury John E; Dikic Ivan
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.
The Journal of biological chemistry 2003;278(41):39735-46.
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2003: O'Rourke Lisa; Ladbury John E
Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling.
Accounts of chemical research 2003;36(6):410-6.
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2003: Bergqvist S; Williams M A; O'Brien R; Ladbury J E
Halophilic adaptation of protein-DNA interactions.
Biochemical Society transactions 2003;31(Pt 3):677-80.
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2002: Esposito Diego; Petrovic Arsen; Harris Richard; Ono Shusuke; Eccleston John F; Mbabaali Amina; Haq Ihtshamul; Higgins Christopher F; Hinton Jay C D; Driscoll Paul C; Ladbury John E
H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.
Journal of molecular biology 2002;324(4):841-50.
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2002: Salek Reza M; Williams Mark A; Prodromou Chrisostomos; Pearl Laurence H; Ladbury John E
Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone.
Journal of biomolecular NMR 2002;23(4):327-8.
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2002: Flatman Ruth; McLauchlan W Russell; Juge Nathalie; Furniss Caroline; Berrin Jean-Guy; Hughes Richard K; Manzanares Paloma; Ladbury John E; O'Brien Ronan; Williamson Gary
Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat.
The Biochemical journal 2002;365(Pt 3):773-81.
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2002: Low Lieh Yoon; Hernández Helena; Robinson Carol V; O'Brien Ronan; Grossmann J Günter; Ladbury John E; Luisi Ben
Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.
Journal of molecular biology 2002;319(1):87-106.
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2002: Bergqvist Simon; Williams Mark A; O'Brien Ronan; Ladbury John E
Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy.
Structure (London, England : 1993) 2002;10(5):629-37.
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2002: Lachenmann Marcel J; Ladbury John E; Phillips Nelson B; Narayana Narendra; Qian Xiuqi; Weiss Michael A
The hidden thermodynamics of a zinc finger.
Journal of molecular biology 2002;316(4):969-89.
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2001: Haq I; O'Brien R; Lagunavicius A; Siksnys V; Ladbury J E
Specific DNA recognition by the type II restriction endonuclease MunI: the effect of pH.
Biochemistry 2001;40(49):14960-7.
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2001: Henriques D A; Ladbury J E
Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.
Archives of biochemistry and biophysics 2001;390(2):158-68.
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2001: Lee L; Stollar E; Chang J; Grossmann J G; O'Brien R; Ladbury J; Carpenter B; Roberts S; Luisi B
Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator.
Biochemistry 2001;40(22):6580-8.
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2001: Arold S T; Ulmer T S; Mulhern T D; Werner J M; Ladbury J E; Campbell I D; Noble M E
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
The Journal of biological chemistry 2001;276(20):17199-205.
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2001: Renzoni D; Esposito D; Pfuhl M; Hinton J C; Higgins C F; Driscoll P C; Ladbury J E
Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS.
Journal of molecular biology 2001;306(5):1127-37.
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2001: Bergqvist S; O'Brien R; Ladbury J E
Site-specific cation binding mediates TATA binding protein-DNA interaction from a hyperthermophilic archaeon.
Biochemistry 2001;40(8):2419-25.
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2000: Henriques D A; Ladbury J E; Jackson R M
Comparison of binding energies of SrcSH2-phosphotyrosyl peptides with structure-based prediction using surface area based empirical parameterization.
Protein science : a publication of the Protein Society 2000;9(10):1975-85.
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2000: Prodromou C; Panaretou B; Chohan S; Siligardi G; O'Brien R; Ladbury J E; Roe S M; Piper P W; Pearl L H
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.
The EMBO journal 2000;19(16):4383-92.
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2000: Haq I; Ladbury J
Drug-DNA recognition: energetics and implications for design.
Journal of molecular recognition : JMR 2000;13(4):188-97.
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2000: Kahmann J D; O'Brien R; Werner J M; Heinegârd D; Ladbury J E; Campbell I D; Day A J
Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.
Structure (London, England : 1993) 2000;8(7):763-74.
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2000: Lundbäck T; Chang J F; Phillips K; Luisi B; Ladbury J E
Characterization of sequence-specific DNA binding by the transcription factor Oct-1.
Biochemistry 2000;39(25):7570-9.
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2000: Smyth C P; Lundbäck T; Renzoni D; Siligardi G; Beavil R; Layton M; Sidebotham J M; Hinton J C; Driscoll P C; Higgins C F; Ladbury J E
Oligomerization of the chromatin-structuring protein H-NS.
Molecular microbiology 2000;36(4):962-72.
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2000: O'Brien R; Rugman P; Renzoni D; Layton M; Handa R; Hilyard K; Waterfield M D; Driscoll P C; Ladbury J E
Alternative modes of binding of proteins with tandem SH2 domains.
Protein science : a publication of the Protein Society 2000;9(3):570-9.
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2000: Rostom A A; Tame J R; Ladbury J E; Robinson C V
Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry.
Journal of molecular biology 2000;296(1):269-79.
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1999: Chung E W; Henriques D A; Renzoni D; Morton C J; Mulhern T D; Pitkeathly M C; Ladbury J E; Robinson C V
Probing the nature of interactions in SH2 binding interfaces--evidence from electrospray ionization mass spectrometry.
Protein science : a publication of the Protein Society 1999;8(10):1962-70.
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1999: Sleigh S H; Seavers P R; Wilkinson A J; Ladbury J E; Tame J R
Crystallographic and calorimetric analysis of peptide binding to OppA protein.
Journal of molecular biology 1999;291(2):393-415.
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1999: Chang J F; Phillips K; Lundbäck T; Gstaiger M; Ladbury J E; Luisi B
Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding.
Journal of molecular biology 1999;288(5):941-52.
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1999: Prodromou C; Siligardi G; O'Brien R; Woolfson D N; Regan L; Panaretou B; Ladbury J E; Piper P W; Pearl L H
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.
The EMBO journal 1999;18(3):754-62.
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1999: Roe S M; Prodromou C; O'Brien R; Ladbury J E; Piper P W; Pearl L H
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Journal of medicinal chemistry 1999;42(2):260-6.
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1998: Chung E; Henriques D; Renzoni D; Zvelebil M; Bradshaw J M; Waksman G; Robinson C V; Ladbury J E
Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.
Structure (London, England : 1993) 1998;6(9):1141-51.
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1998: Panaretou B; Prodromou C; Roe S M; O'Brien R; Ladbury J E; Piper P W; Pearl L H
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.
The EMBO journal 1998;17(16):4829-36.
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1998: Bradshaw J M; Grucza R A; Ladbury J E; Waksman G
Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.
Biochemistry 1998;37(25):9083-90.
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1998: O'Brien R; DeDecker B; Fleming K G; Sigler P B; Ladbury J E
The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon.
Journal of molecular biology 1998;279(1):117-25.
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1997: Haq I; Ladbury J E; Chowdhry B Z; Jenkins T C; Chaires J B
Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies.
Journal of molecular biology 1997;271(2):244-57.
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1997: Prodromou C; Roe S M; O'Brien R; Ladbury J E; Piper P W; Pearl L H
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.
Cell 1997;90(1):65-75.
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1997: O'Brien R; Wynn R; Driscoll P C; Davis B; Plaxco K W; Sturtevant J M; Ladbury J E
The adaptability of Escherichia coli thioredoxin to non-conservative amino acid substitutions.
Protein science : a publication of the Protein Society 1997;6(6):1325-32.
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1997: Tsai F T; Singh O M; Skarzynski T; Wonacott A J; Weston S; Tucker A; Pauptit R A; Breeze A L; Poyser J P; O'Brien R; Ladbury J E; Wigley D B
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.
Proteins 1997;28(1):41-52.
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1996: Ladbury J E
Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.
Chemistry & biology 1996;3(12):973-80.
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1996: Renzoni D A; Pugh D J; Siligardi G; Das P; Morton C J; Rossi C; Waterfield M D; Campbell I D; Ladbury J E
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry 1996;35(49):15646-53.
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1996: Ladbury J E; Chowdhry B Z
Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.
Chemistry & biology 1996;3(10):791-801.
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1996: Morton C J; Ladbury J E
Water-mediated protein-DNA interactions: the relationship of thermodynamics to structural detail.
Protein science : a publication of the Protein Society 1996;5(10):2115-8.
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1996: Ladbury J E; Hensmann M; Panayotou G; Campbell I D
Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: implications for regulation of tyrosine kinase activity.
Biochemistry 1996;35(34):11062-9.
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1995: Ladbury J E
Counting the calories to stay in the groove.
Structure (London, England : 1993) 1995;3(7):635-9.
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1995: Ladbury J E; Lemmon M A; Zhou M; Green J; Botfield M C; Schlessinger J
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3199-203.
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1995: Ladbury J E; Wynn R; Thomson J A; Sturtevant J M
Substitution of charged residues into the hydrophobic core of Escherichia coli thioredoxin results in a change in heat capacity of the native protein.
Biochemistry 1995;34(7):2148-52.
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1994: Spivak-Kroizman T; Lemmon M A; Dikic I; Ladbury J E; Pinchasi D; Huang J; Jaye M; Crumley G; Schlessinger J; Lax I
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.
Cell 1994;79(6):1015-24.
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1994: Lemmon M A; Ladbury J E; Mandiyan V; Zhou M; Schlessinger J
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
The Journal of biological chemistry 1994;269(50):31653-8.
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1994: Ladbury J; Peters R
Turning up the heat on rational drug design.
Bio/technology (Nature Publishing Company) 1994;12(11):1083-5.
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1994: Ladbury J E; Sturtevant J M; Leontis N B
The thermodynamics of formation of a three-strand, DNA three-way junction complex.
Biochemistry 1994;33(22):6828-33.
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1994: Ladbury J E; Wright J G; Sturtevant J M; Sigler P B
A thermodynamic study of the trp repressor-operator interaction.
Journal of molecular biology 1994;238(5):669-81.
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1994: Lemmon M A; Ladbury J E
Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck.
Biochemistry 1994;33(17):5070-6.
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1994: Ladbury J E; Kishore N; Hellinga H W; Wynn R; Sturtevant J M
Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.
Biochemistry 1994;33(12):3688-92.
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1993: Ladbury J E; Wynn R; Hellinga H W; Sturtevant J M
Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.
Biochemistry 1993;32(29):7526-30.
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1992: Ladbury J E; Hu C Q; Sturtevant J M
A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme.
Biochemistry 1992;31(44):10699-702.
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