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John Ladbury

Research Profile

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Thermodynamics

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Indhu Kanakaraj; Katerina Kourentzi; John E Ladbury; Mohan Poongavanam; Loren J Stagg; Ulrich Strych; Wen-Hsiang Chen; Sagar Dhamane; Richard C Willson
Biophysical characterization of VEGF-aHt DNA aptamer interactions.
Kin Man Suen; Chi-Chuan Lin; Fernando A Melo; Zamal Ahmed; Stefan T Arold; Swathi Arur; Eleanor R Biggs; Melanie N Drake; Roger George; John E Ladbury
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
Xiaoxiao Cheng; Mark D Carr; Edward J Evans; Robert Griffin; Meryn Griffiths; Alistair J Henry; Jiandong Huo; Shinji Ikemizu; Andreas Jansson; John E Ladbury; Alasdair J Leslie; Sara H Morgan; Frederick W Muskett; Anand Radhakrishnan; Colin Stubberfield; Vaclav Veverka; Lorna C Waters; Chao Yu; Simon J Davis
Structure and interactions of the human programmed cell death 1 receptor.

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All Publications

2013: Indhu Kanakaraj; Katerina Kourentzi; John E Ladbury; Mohan Poongavanam; Loren J Stagg; Ulrich Strych; Wen-Hsiang Chen; Sagar Dhamane; Richard C Willson
Biophysical characterization of VEGF-aHt DNA aptamer interactions.
International journal of biological macromolecules 2013;57():69-75.
2013: Kin Man Suen; Chi-Chuan Lin; Fernando A Melo; Zamal Ahmed; Stefan T Arold; Swathi Arur; Eleanor R Biggs; Melanie N Drake; Roger George; John E Ladbury
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
Nature structural & molecular biology 2013;20(5):620-7.
2013: Xiaoxiao Cheng; Mark D Carr; Edward J Evans; Robert Griffin; Meryn Griffiths; Alistair J Henry; Jiandong Huo; Shinji Ikemizu; Andreas Jansson; John E Ladbury; Alasdair J Leslie; Sara H Morgan; Frederick W Muskett; Anand Radhakrishnan; Colin Stubberfield; Vaclav Veverka; Lorna C Waters; Chao Yu; Simon J Davis
Structure and interactions of the human programmed cell death 1 receptor.
The Journal of biological chemistry 2013;288(17):11771-85.
2013: Susanne A I Seidel; Anton Simeonov; Prakash Srinivasan; Geert van den Bogaart; Anthony Watts; Philipp Baaske; Dieter Braun; Patricia M Dijkman; Moran Jerabek-Willemsen; Jeremiah S Joseph; Ilia Katritch; John E Ladbury; Ana Lazic; Wendy A Lea; Fernando A Melo; Gideon Schreiber; Stefan Duhr
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions.
Methods (San Diego, Calif.) 2013;59(3):301-15.
2013: Zamal Ahmed; James A Levitt; Chi-Chuan Lin; Fernando A Melo; Kin M Suen; Klaus Suhling; John E Ladbury
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
The Journal of cell biology 2013;200(4):493-504.
2012: Chi-Chuan Lin; Fernando A Melo; Loren J Stagg; Kin M Suen; Zamal Ahmed; Stefan T Arold; Ragini Ghosh; John Kirkpatrick; John E Ladbury
Inhibition of basal FGF receptor signaling by dimeric Grb2.
Cell 2012;149(7):1514-24.
2012: Zhen Chen; Jane M Coughlin; John E Ladbury; Loren J Stagg; Farrukh Vohidov; Stefan T Arold; Zachary T Ball
Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.
Journal of the American Chemical Society 2012;134(24):10138-45.
2012: John E Ladbury; Stefan T Arold
Noise in cellular signaling pathways: causes and effects.
Trends in biochemical sciences 2012;37(5):173-8.
2012: Muthu Ramakrishnan; Fernando Alves De Melo; Berma M Kinsey; Thomas R Kosten; John E Ladbury; Frank M Orson
Probing cocaine-antibody interactions in buffer and human serum.
PloS one 2012;7(7):e40518.
2011: Martin Noble; John E Ladbury
Catalysis and regulation.
Current opinion in structural biology 2011;21(6):775-6.
2011: Tjelvar S G Olsson; William Pitt; John E Ladbury; Mark A Williams
Extent of enthalpy-entropy compensation in protein-ligand interactions.
Protein science : a publication of the Protein Society 2011;20(9):1607-18.
2011: D Philippe; Abdessamad Ababou; X Yang; R Ghosh; T Daviter; John E Ladbury; Mark Pfuhl
Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85.
Biochemistry 2011;50(18):3649-59.
2011: Chao Yu; Andreas F-P Sonnen; Roger George; Benoit H Dessailly; Loren J Stagg; Edward J Evans; Christine A Orengo; David I Stuart; John E Ladbury; Shinji Ikemizu; Robert J C Gilbert; Simon J Davis
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
The Journal of biological chemistry 2011;286(8):6685-96.
2011: John E Ladbury; Stefan T Arold
Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling.
Methods in enzymology 2011;488():147-83.
2010: Stefan T Arold; Paul G Leonard; Gary N Parkinson; John E Ladbury
H-NS forms a superhelical protein scaffold for DNA condensation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15728-32.
2010: John E Ladbury
Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design.
Biochemical Society transactions 2010;38(4):888-93.
2010: Claire N Stevens; Ann-Marie Simeone; Susan John; Zamal Ahmed; Orso M Lucherini; Cosima T Baldari; John E Ladbury
T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.
The Biochemical journal 2010;428(3):429-37.
2010: Paul G Leonard; Gary N Parkinson; Jayesh Gor; Stephen J Perkins; John E Ladbury
The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 4):421-5.
2010: John E Ladbury; Gerhard Klebe; Ernesto Freire
Adding calorimetric data to decision making in lead discovery: a hot tip.
Nature reviews. Drug discovery 2010;9(1):23-7.
2010: Zamal Ahmed; Roger George; Chi-Chuan Lin; Kin Man Suen; James A Levitt; Klaus Suhling; John E Ladbury
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.
Cellular signalling 2010;22(1):23-33.
2009: Sanjay Nilapwar; Eleanor Williams; Christopher Fu; Chrisostomos Prodromou; Laurence H Pearl; Mark A Williams; John E Ladbury
Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.
Journal of molecular biology 2009;392(4):923-36.
2009: Paul G Leonard; Shusuke Ono; Jayesh Gor; Stephen J Perkins; John E Ladbury
Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.
Molecular microbiology 2009;73(2):165-79.
2009: Abdessamad Ababou; Mark Pfuhl; John E Ladbury
Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.
Journal of molecular biology 2009;387(5):1120-36.
2009: Lihong Zhou; Jiejin Li; Roger George; Sandrine Ruchaud; Hong-Gang Zhou; John E Ladbury; William C Earnshaw; Xuemei Yuan
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.
Biochemistry 2009;48(6):1156-61.
2009: R George; H-L Chan; Zamal Ahmed; K M Suen; C N Stevens; J A Levitt; Klaus Suhling; J Timms; John E Ladbury
A complex of Shc and Ran-GTPase localises to the cell nucleus.
Cellular and molecular life sciences : CMLS 2009;66(4):711-20.
2008: Tjelvar S G Olsson; Mark A Williams; William Pitt; John E Ladbury
The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.
Journal of molecular biology 2008;384(4):1002-17.
2008: Annika C Schüller; Zamal Ahmed; James A Levitt; Kin M Suen; Klaus Suhling; John E Ladbury
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).
The Biochemical journal 2008;416(2):189-99.
2008: Jonathan David Taylor; Abdessamad Ababou; Radwan R Fawaz; Christopher J Hobbs; Mark A Williams; John E Ladbury
Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design.
Proteins 2008;73(4):929-40.
2008: Abdessamad Ababou; Mark Pfuhl; John E Ladbury
The binding stoichiometry of CIN85 SH3 domain A and cbl-b.
Nature structural & molecular biology 2008;15(9):890-1; author reply 891-2.
2008: Seema Patel; Roger George; Flavia Autore; Franca Fraternali; John E Ladbury; Penka V Nikolova
Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.
Nucleic acids research 2008;36(16):5139-51.
2008: Zamal Ahmed; Annika C Schüller; Klaus Suhling; Carolyn Tregidgo; John E Ladbury
Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.
The Biochemical journal 2008;413(1):37-49.
2008: Roger George; Annika C Schuller; Richard Harris; John E Ladbury
A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.
Journal of molecular biology 2008;377(3):740-7.
2008: Annika C Schüller; Zamal Ahmed; John E Ladbury
Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation.
The Biochemical journal 2008;410(1):205-11.
2007: Jonathan David Taylor; Philip J Gilbert; Mark A Williams; William Pitt; John E Ladbury
Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.
Proteins 2007;67(4):981-90.
2007: Antonietta Impagliazzo; Anneloes J Blok; Matthew J Cliff; John E Ladbury; Marcellus Ubbink
Redox-state-dependent complex formation between pseudoazurin and nitrite reductase.
Journal of the American Chemical Society 2007;129(1):226-33.
2007: John E Ladbury
Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 1):26-31.
2007: Abdessamad Ababou; John E Ladbury
Survey of the year 2005: literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2007;20(1):4-14.
2006: Edward J Evans; Mónica A A Castro; Ronan O'Brien; Alice Kearney; Heather Walsh; Lisa M Sparks; Michael G Tucknott; Elizabeth A Davies; Alexandre M Carmo; Philip van der Merwe; David I Stuart; E Yvonne Jones; John E Ladbury; Shinji Ikemizu; Simon J Davis
Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
The Journal of biological chemistry 2006;281(39):29309-20.
2006: Fabienne Beuron; Ingrid Dreveny; Xuemei Yuan; Valerie E Pye; Ciaran McKeown; Louise C Briggs; Matthew J Cliff; Yayoi Kaneko; Russell Wallis; Rivka L Isaacson; John E Ladbury; Steve J Matthews; Hisao Kondo; Xiaodong Zhang; Paul S Freemont
Conformational changes in the AAA ATPase p97-p47 adaptor complex.
The EMBO journal 2006;25(9):1967-76.
2006: Matthew J Cliff; Richard Harris; David Barford; John E Ladbury; Mark A Williams
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
Structure (London, England : 1993) 2006;14(3):415-26.
2006: Alex Grunau; Mark Paine; John E Ladbury; Aldo Gutierrez
Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.
Biochemistry 2006;45(5):1421-34.
2006: Jose Zavaleta; Dinora B Chinchilla; Catherine F Kaddis; Karla Martinez; Abby Brown; Alvaro Gomez; Amaris Pao; Alejandra Ramirez; Sanjay Nilapwar; John E Ladbury; Frank A Gomez
Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.
Journal of capillary electrophoresis and microchip technology 2006;9(5-6):101-17.
2006: Abdessamad Ababou; John E Ladbury
Survey of the year 2004: literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2006;19(1):79-89.
2005: Zamal Ahmed; Carolyn A Beeton; Mark A Williams; Darran Clements; Cosima T Baldari; John E Ladbury
Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.
Journal of molecular biology 2005;353(5):1001-10.
2005: Shusuke Ono; Martin D Goldberg; Tjelvar Olsson; Diego Esposito; Jay Hinton; John E Ladbury
H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.
The Biochemical journal 2005;391(Pt 2):203-13.
2005: Jonathan David Taylor; Radwan R Fawaz; Abdessamad Ababou; Mark A Williams; John E Ladbury
NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src.
Journal of biomolecular NMR 2005;32(4):339.
2005: Matthew J Cliff; Mark A Williams; John Brooke-Smith; David Barford; John E Ladbury
Molecular recognition via coupled folding and binding in a TPR domain.
Journal of molecular biology 2005;346(3):717-32.
2005: Jing Yang; S Mark Roe; Matthew J Cliff; Mark A Williams; John E Ladbury; Patricia T W Cohen; David Barford
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
The EMBO journal 2005;24(1):1-10.
2004: John E Ladbury
Application of isothermal titration calorimetry in the biological sciences: things are heating up!
BioTechniques 2004;37(6):885-7.
2004: Marcel J Lachenmann; John E Ladbury; Xiuqi Qian; Kun Huang; Rupinder Singh; Michael A Weiss
Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice.
Protein science : a publication of the Protein Society 2004;13(12):3115-26.
2004: Marcel J Lachenmann; John E Ladbury; Jian Dong; Kun Huang; Paul Carey; Michael A Weiss
Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.
Biochemistry 2004;43(44):13910-25.
2004: Matthew J Cliff; Aldo Gutierrez; John E Ladbury
A survey of the year 2003 literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2004;17(6):513-23.
2004: John E Ladbury; Mark A Williams
The extended interface: measuring non-local effects in biomolecular interactions.
Current opinion in structural biology 2004;14(5):562-9.
2004: Simon Bergqvist; Mark A Williams; Ronan O'Brien; John E Ladbury
Heat capacity effects of water molecules and ions at a protein-DNA interface.
Journal of molecular biology 2004;336(4):829-42.
2003: Matthew J Cliff; John E Ladbury
A survey of the year 2002 literature on applications of isothermal titration calorimetry.
Journal of molecular recognition : JMR 2003;16(6):383-91.
2003: Katarzyna Kowanetz; Iwona Pilecka; Kaisa Haglund; Marcin Kowanetz; Koraljka Husnjak; Jonathan David Taylor; Philippe Soubeyran; Ulla Engstrom; John E Ladbury; Ivan Dikic
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.
The Journal of biological chemistry 2003;278(41):39735-46.
2003: Lisa O'Rourke; John E Ladbury
Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling.
Accounts of chemical research 2003;36(6):410-6.
2003: Simon Bergqvist; Mark A Williams; Ronan O'Brien; John E Ladbury
Halophilic adaptation of protein-DNA interactions.
Biochemical Society transactions 2003;31(Pt 3):677-80.
2002: Diego Esposito; Arsen Petrovic; Richard Harris; Shusuke Ono; John F Eccleston; Amina Mbabaali; Ihtshamul Haq; Christopher F Higgins; Jay Hinton; Paul C Driscoll; John E Ladbury
H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.
Journal of molecular biology 2002;324(4):841-50.
2002: Reza M Salek; Mark A Williams; Chrisostomos Prodromou; Laurence H Pearl; John E Ladbury
Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone.
Journal of biomolecular NMR 2002;23(4):327-8.
2002: Ruth Flatman; W Russell McLauchlan; Nathalie Juge; Caroline Furniss; Jean-Guy Berrin; Richard K Hughes; Paloma Manzanares; John E Ladbury; Ronan O'Brien; Gary Williamson
Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat.
The Biochemical journal 2002;365(Pt 3):773-81.
2002: low lieh; Helena Hernández; Carol V Robinson; Ronan O'Brien; J Günter Grossmann; John E Ladbury; Ben F Luisi
Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.
Journal of molecular biology 2002;319(1):87-106.
2002: Simon Bergqvist; Mark A Williams; Ronan O'Brien; John E Ladbury
Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy.
Structure (London, England : 1993) 2002;10(5):629-37.
2002: Marcel J Lachenmann; John E Ladbury; Nelson B Phillips; Narendra Narayana; Xiuqi Qian; Michael A Weiss
The hidden thermodynamics of a zinc finger.
Journal of molecular biology 2002;316(4):969-89.
2001: Ihtshamul Haq; Ronan O'Brien; Arunas Lagunavicius; Virginijus Siksnys; John E Ladbury
Specific DNA recognition by the type II restriction endonuclease MunI: the effect of pH.
Biochemistry 2001;40(49):14960-7.
2001: DA Henriques; John E Ladbury
Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.
Archives of biochemistry and biophysics 2001;390(2):158-68.
2001: L Lee; E Stollar; J Chang; J Günter Grossmann; R O'Brien; John E Ladbury; B Carpenter; S Roberts; Ben F Luisi
Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator.
Biochemistry 2001;40(22):6580-8.
2001: Stefan T Arold; Tobias S Ulmer; TD Mulhern; Joern Werner; John E Ladbury; Iain D Campbell; Martin E M Noble
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
The Journal of biological chemistry 2001;276(20):17199-205.
2001: D Renzoni; Diego Esposito; Mark Pfuhl; Jay Hinton; Christopher F Higgins; Paul C Driscoll; John E Ladbury
Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS.
Journal of molecular biology 2001;306(5):1127-37.
2001: Simon Bergqvist; Ronan O'Brien; John E Ladbury
Site-specific cation binding mediates TATA binding protein-DNA interaction from a hyperthermophilic archaeon.
Biochemistry 2001;40(8):2419-25.
2000: DA Henriques; John E Ladbury; R M Jackson
Comparison of binding energies of SrcSH2-phosphotyrosyl peptides with structure-based prediction using surface area based empirical parameterization.
Protein science : a publication of the Protein Society 2000;9(10):1975-85.
2000: Chrisostomos Prodromou; Barry Panaretou; S Chohan; Giuliano Siligardi; Ronan O'Brien; John E Ladbury; S Mark Roe; Peter W Piper; Laurence H Pearl
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.
The EMBO journal 2000;19(16):4383-92.
2000: Jan D Kahmann; R O'Brien; Joern Werner; D Heinegârd; John E Ladbury; Iain D Campbell; Anthony J Day
Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.
Structure (London, England : 1993) 2000;8(7):763-74.
2000: Ihtshamul Haq; John E Ladbury
Drug-DNA recognition: energetics and implications for design.
Journal of molecular recognition : JMR 2000;13(4):188-97.
2000: T Lundbäck; Jui-Fen Chang; K Phillips; Ben F Luisi; John E Ladbury
Characterization of sequence-specific DNA binding by the transcription factor Oct-1.
Biochemistry 2000;39(25):7570-9.
2000: C P Smyth; T Lundbäck; D Renzoni; Giuliano Siligardi; R Beavil; M Layton; J M Sidebotham; Jay Hinton; Paul C Driscoll; Christopher F Higgins; John E Ladbury
Oligomerization of the chromatin-structuring protein H-NS.
Molecular microbiology 2000;36(4):962-72.
2000: Ronan O'Brien; P Rugman; D Renzoni; M Layton; R Handa; K Hilyard; M D Waterfield; Paul C Driscoll; John E Ladbury
Alternative modes of binding of proteins with tandem SH2 domains.
Protein science : a publication of the Protein Society 2000;9(3):570-9.
2000: A A Rostom; Jeremy R H Tame; John E Ladbury; Carol V Robinson
Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry.
Journal of molecular biology 2000;296(1):269-79.
1999: EW Chung; DA Henriques; D Renzoni; CJ Morton; TD Mulhern; MC Pitkeathly; John E Ladbury; Carol V Robinson
Probing the nature of interactions in SH2 binding interfaces--evidence from electrospray ionization mass spectrometry.
Protein science : a publication of the Protein Society 1999;8(10):1962-70.
1999: S H Sleigh; PR Seavers; Anthony J Wilkinson; John E Ladbury; Jeremy R H Tame
Crystallographic and calorimetric analysis of peptide binding to OppA protein.
Journal of molecular biology 1999;291(2):393-415.
1999: Jui-Fen Chang; K Phillips; T Lundbäck; Matthias Gstaiger; John E Ladbury; Ben F Luisi
Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding.
Journal of molecular biology 1999;288(5):941-52.
1999: Chrisostomos Prodromou; Giuliano Siligardi; Ronan O'Brien; Derek N Woolfson; L Regan; Barry Panaretou; John E Ladbury; Peter W Piper; Laurence H Pearl
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.
The EMBO journal 1999;18(3):754-62.
1999: S Mark Roe; Chrisostomos Prodromou; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Journal of medicinal chemistry 1999;42(2):260-6.
1998: E Chung; DA Henriques; D Renzoni; Marketa Zvelebil; J Michael Bradshaw; Gabriel Waksman; Carol V Robinson; John E Ladbury
Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.
Structure (London, England : 1993) 1998;6(9):1141-51.
1998: Barry Panaretou; Chrisostomos Prodromou; S Mark Roe; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.
The EMBO journal 1998;17(16):4829-36.
1998: J Michael Bradshaw; Richard A Grucza; John E Ladbury; Gabriel Waksman
Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.
Biochemistry 1998;37(25):9083-90.
1998: Ronan O'Brien; B DeDecker; Karen Fleming; Paul B Sigler; John E Ladbury
The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon.
Journal of molecular biology 1998;279(1):117-25.
1997: Ihtshamul Haq; John E Ladbury; Babur Z Chowdhry; Terence C Jenkins; JB Chaires
Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies.
Journal of molecular biology 1997;271(2):244-57.
1997: Chrisostomos Prodromou; S Mark Roe; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.
Cell 1997;90(1):65-75.
1997: Ronan O'Brien; R Wynn; Paul C Driscoll; Ben Davis; K W Plaxco; Julian M Sturtevant; John E Ladbury
The adaptability of Escherichia coli thioredoxin to non-conservative amino acid substitutions.
Protein science : a publication of the Protein Society 1997;6(6):1325-32.
1997: Francis T F Tsai; O M Singh; T Skarzynski; Alan J Wonacott; S Weston; A Tucker; Richard A Pauptit; Alexander L Breeze; J P Poyser; R O'Brien; John E Ladbury; D B Wigley
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.
Proteins 1997;28(1):41-52.
1996: D Renzoni; D J Pugh; Giuliano Siligardi; P Das; CJ Morton; C Rossi; Michael D Waterfield; Iain D Campbell; John E Ladbury
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry 1996;35(49):15646-53.
1996: John E Ladbury
Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.
Chemistry & biology 1996;3(12):973-80.
1996: John E Ladbury; Babur Z Chowdhry
Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.
Chemistry & biology 1996;3(10):791-801.
1996: CJ Morton; John E Ladbury
Water-mediated protein-DNA interactions: the relationship of thermodynamics to structural detail.
Protein science : a publication of the Protein Society 1996;5(10):2115-8.
1996: John E Ladbury; M Hensmann; George Panayotou; Iain D Campbell
Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: implications for regulation of tyrosine kinase activity.
Biochemistry 1996;35(34):11062-9.
1995: John E Ladbury
Counting the calories to stay in the groove.
Structure (London, England : 1993) 1995;3(7):635-9.
1995: John E Ladbury; Mark A Lemmon; M Zhou; jeremy green; M C Botfield; Joseph Schlessinger
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3199-203.
1995: John E Ladbury; R Wynn; J A Thomson; Julian M Sturtevant
Substitution of charged residues into the hydrophobic core of Escherichia coli thioredoxin results in a change in heat capacity of the native protein.
Biochemistry 1995;34(7):2148-52.
1994: T Spivak-Kroizman; Mark A Lemmon; Ivan Dikic; John E Ladbury; D Pinchasi; Jiaoti Huang; Michael Jaye; G Crumley; Joseph Schlessinger; Irit Lax
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.
Cell 1994;79(6):1015-24.
1994: Mark A Lemmon; John E Ladbury; Valsan Mandiyan; M Zhou; Joseph Schlessinger
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
The Journal of biological chemistry 1994;269(50):31653-8.
1994: John E Ladbury; R Peters
Turning up the heat on rational drug design.
Bio/technology (Nature Publishing Company) 1994;12(11):1083-5.
1994: John E Ladbury; Julian M Sturtevant; Neocles Leontis
The thermodynamics of formation of a three-strand, DNA three-way junction complex.
Biochemistry 1994;33(22):6828-33.
1994: John E Ladbury; J G Wright; Julian M Sturtevant; Paul B Sigler
A thermodynamic study of the trp repressor-operator interaction.
Journal of molecular biology 1994;238(5):669-81.
1994: Mark A Lemmon; John E Ladbury
Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck.
Biochemistry 1994;33(17):5070-6.
1994: John E Ladbury; N Kishore; H W Hellinga; R Wynn; Julian M Sturtevant
Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.
Biochemistry 1994;33(12):3688-92.
1993: John E Ladbury; R Wynn; H W Hellinga; Julian M Sturtevant
Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.
Biochemistry 1993;32(29):7526-30.
1992: John E Ladbury; C Q Hu; Julian M Sturtevant
A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme.
Biochemistry 1992;31(44):10699-702.