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Warren Ladiges

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Ruimao Zheng; Maria A Sikorski; Linghai Yang; Traci A Czyzyk; Linda C Enns; Warren C Ladiges; G Stanley McKnight
Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.
Sarah J Cullen; Soroosh Fatemie; Warren C Ladiges
Breast tumor cells primed by endoplasmic reticulum stress remodel macrophage phenotype.
Jorming Goh; Warren C Ladiges
A novel long term short interval physical activity regime improves body composition in mice.

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2013: Ruimao Zheng; Maria A Sikorski; Linghai Yang; Traci A Czyzyk; Linda C Enns; Warren C Ladiges; G Stanley McKnight
Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):E1631-40.
2013: Sarah J Cullen; Soroosh Fatemie; Warren C Ladiges
Breast tumor cells primed by endoplasmic reticulum stress remodel macrophage phenotype.
American journal of cancer research 2013;3(2):196-210.
2013: Jorming Goh; Warren C Ladiges
A novel long term short interval physical activity regime improves body composition in mice.
BMC research notes 2013;6():66.
2012: Linda C Enns; Warren C Ladiges
Mitochondrial redox signaling and cancer invasiveness.
Journal of bioenergetics and biomembranes 2012;44(6):635-8.
2012: Fresnida J Ramos; Katherine H Schreiber; Randy Strong; Elroy H An; Steven C Chen; Dao-Fu Dai; Michael G Garelick; Matt Kaeberlein; Warren C Ladiges; Chen-Yu Liao; Vivian L MacKay; Peter S Rabinovitch; Brian Kennedy
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Science translational medicine 2012;4(144):144ra103.
2012: Richard L Frock; Christina Brown; Steven C Chen; Dao-Fu Da; Ellie Frett; Warren C Ladiges; Carmen Lau; Antoine Muchir; Diana N Pak; Peter S Rabinovitch; Luis F Santana; Yuexia Wang; Howard J Worman; Brian Kennedy
Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.
PloS one 2012;7(8):e42918.
2012: Jorming Goh; Elizabeth A Kirk; Shu Xian Lee; Warren C Ladiges
Exercise, physical activity and breast cancer: the role of tumor-associated macrophages.
Exercise immunology review 2012;18():158-76.
2012: Christina Pettan-Brewer; Julia Sidorova; John Morton; Rebecca Coil; Sarah Cullen; Linda Enns; Jorming Goh; Keffy Rm Kehrli; Warren C Ladiges
Tumor growth is suppressed in mice expressing a truncated XRCC1 protein.
American journal of cancer research 2012;2(2):168-77.
2011: Daniel R McNeill; Marshall G Miller; Christina Pettan-Brewer; Paul J Pistell; RICHARD SPENCER; Nadja C de Souza-Pinto; Kenneth W Fishbein; Warren C Ladiges; Ping-Chang Lin; Yie Liu; David M Wilson
XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility.
Nucleic acids research 2011;39(18):7992-8004.
2011: Jesse C Wiley; Christina Pettan-Brewer; Warren C Ladiges
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.
Aging cell 2011;10(3):418-28.
2011: Jorming Goh; Heather Hopkins; Linda C Enns; Soroosh Fatemie; John Morton; Christina Pettan-Brewer; Warren C Ladiges
Mitochondrial targeted catalase suppresses invasive breast cancer in mice.
BMC cancer 2011;11():191.
2010: Linda C Enns; Warren C Ladiges
Protein kinase A signaling as an anti-aging target.
Ageing research reviews 2010;9(3):269-72.
2010: Kiranjit K Dhillon; Julia M Sidorova; Tina M Albertson; Judith B Anderson; Warren C Ladiges; Peter S Rabinovitch; Bradley D Preston; Raymond J Monnat
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.
DNA repair 2010;9(1):11-22.
2010: Linda C Enns; Kenneth L Bible; Mary J Emond; Warren C Ladiges
Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction.
BMC research notes 2010;3():307.
2010: Jesse C Wiley; James S Meabon; Harald Frankowski; Elise A Smith; Leslayann C Schecterson; Mark Bothwell; Warren C Ladiges
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.
PloS one 2010;5(2):e9135.
2009: Linda C Enns; John F Morton; Ruby Sue Mangalindan; G Stanley McKnight; Michael W Schwartz; Matt R Kaeberlein; Brian Kennedy; Peter S Rabinovitch; Warren C Ladiges
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(12):1221-31.
2009: Dao-Fu Dai; Luis F Santana; Marc Vermulst; Daniela M Tomazela; Mary J Emond; Michael J MacCoss; Katherine Gollahon; George M Martin; Lawrence A Loeb; Warren C Ladiges; Peter S Rabinovitch
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.
Circulation 2009;119(21):2789-97.
2009: Linda C Enns; John F Morton; piper meigs treuting; Mary J Emond; Norman S Wolf; Dao-Fu Dai; G S McKnight; Peter S Rabinovitch; Warren C Ladiges
Disruption of protein kinase A in mice enhances healthy aging.
PloS one 2009;4(6):e5963.
2008: piper meigs treuting; Nancy J Linford; Sue E Knoblaugh; M J Emond; John F Morton; George M Martin; Peter S Rabinovitch; Warren C Ladiges
Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(8):813-22.
2008: Gina Moore; Susan Knoblaugh; Katherine A Gollahon; Peter S Rabinovitch; Warren C Ladiges
Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet.
Mechanisms of ageing and development 2008;129(4):201-6.
2008: Linda C Enns; Jesse C Wiley; Warren C Ladiges
Clinical relevance of transgenic mouse models for aging research.
Critical reviews in eukaryotic gene expression 2008;18(1):81-91.
2007: Jesse C Wiley; Elise A Smith; Mark P Hudson; Warren C Ladiges; Mark Bothwell
Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
The Journal of biological chemistry 2007;282(46):33313-25.
2007: Ranga N Venkatesan; piper meigs treuting; Evan D Fuller; Robert E Goldsby; Thomas H Norwood; Theodore A Gooley; Warren C Ladiges; Bradley D Preston; Lawrence A Loeb
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis.
Molecular and cellular biology 2007;27(21):7669-82.
2007: Lisa A McConnachie; Isaac Mohar; Francesca N Hudson; Carol B Ware; Warren C Ladiges; Carolina Fernandez; Sam Chatterton-Kirchmeier; Collin C White; Robert H Pierce; Terrance J Kavanagh
Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):628-36.
2007: Marc Vermulst; Jason H Bielas; Gregory C Kujoth; Warren C Ladiges; Peter S Rabinovitch; Tomas A Prolla; Lawrence A Loeb
Mitochondrial point mutations do not limit the natural lifespan of mice.
Nature genetics 2007;39(4):540-3.
2006: Dianne Botta; Shengli Shi; Collin C White; Michael J Dabrowski; Cassie L Keener; Sengkeo L Srinouanprachanh; Federico M Farin; Carol B Ware; Warren C Ladiges; Robert H Pierce; Nelson Fausto; Terrance J Kavanagh
Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.
The Journal of biological chemistry 2006;281(39):28865-75.
2006: Jesse C Wiley; Manjula Prattipati; Ching-Ping Lin; Warren C Ladiges
Comparative Mouse Genomics Centers Consortium: the Mouse Genotype Database.
Mutation research 2006;595(1-2):137-44.
2006: Warren C Ladiges
Mouse models of XRCC1 DNA repair polymorphisms and cancer.
Oncogene 2006;25(11):1612-9.
2005: Samuel E Schriner; Nancy J Linford; George M Martin; piper meigs treuting; Charles E Ogburn; Mary J Emond; Pinar E Coskun; Warren C Ladiges; Norman Wolf; Holly Van Remmen; Douglas C Wallace; Peter S Rabinovitch
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Science (New York, N.Y.) 2005;308(5730):1909-11.
2005: Alasdair MacAuley; Warren C Ladiges
Approaches to determine clinical significance of genetic variants.
Mutation research 2005;573(1-2):205-20.
2005: Warren C Ladiges; Sue E Knoblaugh; John F Morton; Marcus J Korth; Bryce L Sopher; Carole R Baskin; Alasdair MacAuley; Alan G Goodman; Renee C LeBoeuf; Michael G Katze
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.
Diabetes 2005;54(4):1074-81.
2004: Warren C Ladiges; C Kemp; J Packenham; J Velazquez
Human gene variation: from SNPs to phenotypes.
Mutation research 2004;545(1-2):131-9.
2003: Carol B Ware; La' Akea N Siverts; Angelique M Nelson; John F Morton; Warren C Ladiges
Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.
Transgenic research 2003;12(6):743-6.
2003: Warren C Ladiges; Jesse C Wiley; Alasdair MacAuley
Polymorphisms in the DNA repair gene XRCC1 and age-related disease.
Mechanisms of ageing and development 2003;124(1):27-32.
2002: Sonja T Chou; Warren C Ladiges
Detection of transgene product in mouse peripheral blood lymphocytes: a minimally invasive microassay.
Comparative medicine 2002;52(6):543-7.
2002: Michelle L Chaisson; John T Brooling; Warren C Ladiges; Sophia Tsai; Nelson Fausto
Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy.
The Journal of clinical investigation 2002;110(2):193-202.
2002: Warren C Ladiges; John Morton; Heather Hopkins; Ruth Wilson; Gina Filley; Carol Ware; Michael Gale
Expression of human PKR protein kinase in transgenic mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(3):329-34.
2002: Warren C Ladiges
The new "mouseketeers".
Lab animal 2002;31(2):9.
2002: piper meigs treuting; H C Hopkins; C A Ware; P R Rabinovitch; Warren C Ladiges
Generation of genetically altered mouse models for aging studies.
Experimental and molecular pathology 2002;72(1):49-55.
2000: Samuel E Schriner; Charles E Ogburn; A C Smith; TG Newcomb; Warren C Ladiges; Martijn E T Dollé; Jan Vijg; Ken-Ichiro Fukuchi; George M Martin
Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei.
Free radical biology & medicine 2000;29(7):664-73.
2000: Warren C Ladiges; J Morton; Collin M Blakely; Michael Gale
Tissue specific expression of PKR protein kinase in aging B6D2F1 mice.
Mechanisms of ageing and development 2000;114(2):123-32.
2000: L Wang; Charles E Ogburn; Carol B Ware; Warren C Ladiges; H Youssoufian; George M Martin; Oshima Junko
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Genetics 2000;154(1):357-62.
1999: GE Osman; Mark Hannibal; J P Anderson; Stephen R Lasky; Warren C Ladiges; Leroy Hood
FVB/N (H2(q)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments.
Immunogenetics 1999;49(10):851-9.
1999: MI Perret-Gentil; L Murray; D J Bird; Warren C Ladiges
Evaluation of FVB/N mice as recipients for transgenic embryos.
Laboratory animal science 1999;49(4):427-8.
1999: GE Osman; Mark Hannibal; J P Anderson; S Cheunsuk; Stephen R Lasky; H Denny Liggitt; Warren C Ladiges; Leroy Hood
T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction.
Immunogenetics 1999;49(9):764-72.
1999: S Cheunsuk; E Gerken; GE Osman; Leroy Hood; Warren C Ladiges
Predictive parameters of joint disease in DBA/1 transgenic mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 1999;54(7):B271-5.
1998: Lee-Way Jin; M G Hearn; Charles E Ogburn; Nick Dang; David Nochlin; Warren C Ladiges; George M Martin
Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis.
The American journal of pathology 1998;153(6):1679-86.
1998: GE Osman; S Cheunsuk; S E Allen; E Chi; H Denny Liggitt; Leroy Hood; Warren C Ladiges
Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice.
International immunology 1998;10(11):1613-22.
1997: C K Varma; S W Li; Leroy Hood; Warren C Ladiges; GE Osman
Rapid detection of bovine type II collagen-specific T-cell hybridomas.
Hybridoma 1997;16(3):287-90.
1997: GE Osman; D P Jacobson; S W Li; Leroy Hood; H Denny Liggitt; Warren C Ladiges
SWR: an inbred strain suitable for generating transgenic mice.
Laboratory animal science 1997;47(2):167-71.
1996: A K Dattamajumdar; S W Li; D P Jacobson; Warren C Ladiges; Leroy Hood; GE Osman
Characterization of the mouse Tcra-V22 gene subfamily.
Immunogenetics 1996;44(6):432-40.
1992: Warren C Ladiges
Alternatives to the use of conventional research animals in neoplasia research.
Journal of the American Veterinary Medical Association 1992;200(5):674-6.
1991: H T Greinix; Warren C Ladiges; T C Graham; S Maslan; R F Raff; Brenda M Sandmaier; Frederick R Appelbaum; Friedrich Schuening; H Joachim Deeg; Rainer Storb
Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody.
Blood 1991;78(8):2131-8.
1990: T E Zimmerman; W E Giddens; R F DiGiacomo; Warren C Ladiges
Soft tissue mineralization in rabbits fed a diet containing excess vitamin D.
Laboratory animal science 1990;40(2):212-5.
1990: Warren C Ladiges; Rainer Storb; R F Raff; Frederick R Appelbaum; Brenda M Sandmaier; Friedrich Schuening; T Graham
Failure of anti-MHC antibodies to prevent GVHD in DLA mismatched unrelated canine marrow recipients.
Bone marrow transplantation 1990;5(1):43-6.
1988: Warren C Ladiges; E Severns; J M Pesando
Comparative reactivity of anti-Ia monoclonal antibodies in man and laboratory animals.
Hybridoma 1988;7(5):465-70.
1988: Warren C Ladiges; M Keast; Frederick R Appelbaum; Rainer Storb
Phenotypic characterization of canine lymphoma, using monoclonal antibodies and a microlymphocytotoxicity assay.
American journal of veterinary research 1988;49(6):870-2.
1988: Warren C Ladiges; J M Pesando; E Severns; Gary Longton; H Joachim Deeg; Rainer Storb
Selective inhibition of the canine mixed lymphocyte response by HLA-DR and DP-reactive monoclonal antibodies.
Transplantation 1988;45(2):484-8.
1988: Warren C Ladiges; H Joachim Deeg; J Pesando; Rainer Storb
Effect of anti-Ia monoclonal antibodies on in vitro immune responses of canine cells.
American journal of veterinary research 1988;49(2):147-51.
1987: H Joachim Deeg; Warren C Ladiges; J Aprile; Friedrich Schuening; R F Raff; Rainer Storb
Monoclonal antibodies to canine differentiation antigens.
Methods and findings in experimental and clinical pharmacology 1987;9(11):749-53.
1987: Warren C Ladiges; R F Raff; Rainer Storb
A DLA-associated polymorphic cell surface determinant defined by the murine monoclonal antibody W3G10.
Animal genetics 1987;18(2):149-58.
1986: H J Deeg; R F Raff; Hans Grosse-Wilde; A M Bijma; W A Buurman; Ilias Doxiadis; H J Kolb; K Krumbacher; Warren C Ladiges; K L Losslein
Joint report of the Third International Workshop on Canine Immunogenetics. I. Analysis of homozygous typing cells.
Transplantation 1986;41(1):111-7.
1985: R F Raff; R Storb; Warren C Ladiges; H J Deeg
Recognition of target cell determinants associated with DLA-D-locus-encoded antigens by canine cytotoxic lymphocytes.
Transplantation 1985;40(3):323-8.
1985: Warren C Ladiges; H J Deeg; R F Raff; R Storb
Immunogenetic aspects of a canine breeding colony.
Laboratory animal science 1985;35(1):58-62.
1984: Warren C Ladiges; R F Raff; S Brown; H J Deeg; R Storb
The canine major histocompatibility complex. Supertypic specificities defined by the primed lymphocyte test (PLT).
Immunogenetics 1984;19(4):359-65.
1982: Warren C Ladiges; R F DiGiacomo; R A Yamaguchi
Prevalence of Toxoplasma gondii antibodies and oocysts in pound-source cats.
Journal of the American Veterinary Medical Association 1982;180(11):1334-5.
1981: Warren C Ladiges; R F DiGiacomo; K J Wardrop; W D Hardy
Prevalence and sequelae of feline leukemia virus infection in laboratory cats.
Journal of the American Veterinary Medical Association 1981;179(11):1206-7.