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Sara Ladu

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Chunmei Wang; Diego F Calvisi; Antonio Cigliano; Salvatore Delogu; Frank Dombrowski; Matthias Evert; Bing Gui; Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Xin Chen
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
Matthias Evert; Gioia Gasparetti; Sara Ladu; Sandra Mattu; Silvia Ribback; Sara Thiel; Andrea Thiele; Antje Zimmermann; Diego F Calvisi; Valentina De Murtas; Salvatore Delogu; Giulia Destefanis; Katja Evert; Frank Dombrowski
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis.
Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Sandra Mattu; Chunmei Wang; Xin Chen; Salvatore Delogu; Giulia Destefanis; Frank Dombrowski; Matthias Evert; Lingling Fan; Julia Armbruster; Diego F Calvisi
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.

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All Publications

2012: Chunmei Wang; Diego F Calvisi; Antonio Cigliano; Salvatore Delogu; Frank Dombrowski; Matthias Evert; Bing Gui; Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Xin Chen
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
Journal of hepatology 2012;57(3):577-83.
2012: Matthias Evert; Gioia Gasparetti; Sara Ladu; Sandra Mattu; Silvia Ribback; Sara Thiel; Andrea Thiele; Antje Zimmermann; Diego F Calvisi; Valentina De Murtas; Salvatore Delogu; Giulia Destefanis; Katja Evert; Frank Dombrowski
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2012;55(5):1473-84.
2012: Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Sandra Mattu; Chunmei Wang; Xin Chen; Salvatore Delogu; Giulia Destefanis; Frank Dombrowski; Matthias Evert; Lingling Fan; Julia Armbruster; Diego F Calvisi
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
Hepatology (Baltimore, Md.) 2012;55(3):833-45.
2011: Maddalena Frau; Sara Ladu; Maria A Seddaiu; Maria M Simile; Maria L Tomasi; Piero Bonelli; Diego F Calvisi; Lucia Daino; Francesco Feo; Rosa M Pascale
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Journal of hepatology 2011;55(1):111-9.
2011: Diego F Calvisi; Maria M Simile; Sara Ladu; Maddalena Frau; Matthias Evert; Maria L Tomasi; Maria I Demartis; Lucia Daino; Maria A Seddaiu; Stefania Brozzetti; Francesco Feo; Rosa M Pascale
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
Hepatology (Baltimore, Md.) 2011;53(4):1226-36.
2011: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Daekwan Seo; Jer-Tsong Hsieh; Valentina M Factor; Snorri S Thorgeirsson
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.
Journal of hepatology 2011;54(2):311-9.
2010: Diego F Calvisi; Federico Pinna; Sara Ladu; Maria R Muroni; Maddalena Frau; Ilaria Demartis; Maria L Tomasi; Marcella Sini; Maria M Simile; Maria A Seddaiu; Francesco Feo; Rosa M Pascale
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
International journal of cancer. Journal international du cancer 2010;126(5):1275-81.
2009: Diego F Calvisi; Sara Ladu; Federico Pinna; Maddalena Frau; Maria L Tomasi; Marcella Sini; Maria M Simile; Piero Bonelli; Maria R Muroni; Maria A Seddaiu; Dae-Sik Lim; Francesco Feo; Rosa M Pascale
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Gastroenterology 2009;137(5):1816-26.e1-10.
2009: Diego F Calvisi; Federico Pinna; Sara Ladu; R Pellegrino; Maria M Simile; Maddalena Frau; Maria R De Miglio; M L Tomasi; Vanna Sanna; Maria R Muroni; Francesco Feo; Rosa M Pascale
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.
Gut 2009;58(5):679-87.
2008: Sara Ladu; Diego F Calvisi; Elizabeth A Conner; Miriam Farina; Valentina M Factor; Snorri S Thorgeirsson
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Gastroenterology 2008;135(4):1322-32.
2008: Diego F Calvisi; Federico Pinna; Sara Ladu; Rossella Pellegrino; Maria R Muroni; Maria M Simile; Maddalena Frau; Maria L Tomasi; Maria R De Miglio; Maria A Seddaiu; Lucia Daino; Valeria Sanna; Francesco Feo; Rosa M Pascale
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease.
Carcinogenesis 2008;29(8):1639-47.
2008: Diego F Calvisi; Federico Pinna; Floriana Meloni; Sara Ladu; Rossella Pellegrino; Marcella Sini; Lucia Daino; Maria M Simile; Maria R De Miglio; Patrizia Virdis; Maddalena Frau; Maria L Tomasi; Maria A Seddaiu; Maria R Muroni; Francesco Feo; Rosa M Pascale
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.
Cancer research 2008;68(11):4192-200.
2007: Diego F Calvisi; Maria M Simile; Sara Ladu; Rossella Pellegrino; Valentina De Murtas; Federico Pinna; Maria L Tomasi; Maddalena Frau; Patrizia Virdis; Maria R De Miglio; Maria R Muroni; Rosa M Pascale; Francesco Feo
Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis.
International journal of cancer. Journal international du cancer 2007;121(11):2410-20.
2007: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Ju Seog Lee; Elizabeth A Conner; Insa S Schroeder; Valentina M Factor; Snorri S Thorgeirsson
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.
The Journal of clinical investigation 2007;117(9):2713-22.
2006: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Elizabeth A Conner; Ju Seog Lee; Valentina M Factor; Snorri S Thorgeirsson
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.
Gastroenterology 2006;130(4):1117-28.
2005: Diego F Calvisi; Elizabeth A Conner; Sara Ladu; Eric R Lemmer; Valentina M Factor; Snorri S Thorgeirsson
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer.
Journal of hepatology 2005;42(6):842-9.
2004: Diego F Calvisi; Sara Ladu; Koji Hironaka; Valentina M Factor; Snorri S Thorgeirsson
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Journal of hepatology 2004;41(5):815-22.
2004: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Disregulation of E-cadherin in transgenic mouse models of liver cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(9):1137-47.
2004: Diego F Calvisi; Sara Ladu; Valentina M Factor; Snorri S Thorgeirsson
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
Carcinogenesis 2004;25(6):901-8.
2004: Diego F Calvisi; Valentina M Factor; Sara Ladu; Elizabeth A Conner; Snorri S Thorgeirsson
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
Gastroenterology 2004;126(5):1374-86.
2002: Maria R De Miglio; Rosa M Pascale; Maria M Simile; Maria R Muroni; Diego F Calvisi; Patrizia Virdis; Giovanni M Bosinco; Maddalena Frau; Maria A Seddaiu; Sara Ladu; Francesco Feo
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.
Cancer research 2002;62(15):4459-63.