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Frank LaFerla

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Michael P Walker; Frank M LaFerla; Salvador S Oddo; Gregory J Brewer
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.
Rodrigo Medeiros; Giselle F Passos; David Baglietto-Vargas; David Cheng; David H Cribbs; Masashi Kitazawa; Frank M LaFerla
Aspirin-triggered lipoxin a4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
Giselle F Passos; Vitaly Vasilevko; David Cheng; Frank M LaFerla; Rodrigo Medeiros; David H Cribbs
The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice.

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2013: Michael P Walker; Frank M LaFerla; Salvador S Oddo; Gregory J Brewer
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.
Age (Dordrecht, Netherlands) 2013;35(3):519-31.
2013: Rodrigo Medeiros; Giselle F Passos; David Baglietto-Vargas; David Cheng; David H Cribbs; Masashi Kitazawa; Frank M LaFerla
Aspirin-triggered lipoxin a4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
The American journal of pathology 2013;182(5):1780-9.
2013: Giselle F Passos; Vitaly Vasilevko; David Cheng; Frank M LaFerla; Rodrigo Medeiros; David H Cribbs
The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice.
The American journal of pathology 2013;182(5):1740-9.
2013: Simantini Ghosh; Stephanos Kyrkanides; Frank M LaFerla; John A Olschowka; Solomon S Shaftel; Michael D Wu; M Kerry O'Banion
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(11):5053-64.
2013: Rodrigo Medeiros; Frank M LaFerla
Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony.
Experimental neurology 2013;239():133-8.
2013: Santiago Solé-Domènech; Lars Terenius; Vladana Vukojevic; Frank M LaFerla; Abdul H Mohammed; K Peter R Nilsson; Sachin Salve; Martin Schalling; Peter Sjövall; Per-Olof Berggren; Nenad Bogdanovic; Alina Codita; Ruani Fernando; Lydia Giménez-Llort; Per Hammarström; Stefan Jacob; Björn Johansson
Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.
Acta neuropathologica 2013;125(1):145-57.
2013: Naoko Soejima; Takeshi Tabira; Ryo Yamasaki; Eri Himeno; Kyoko M Iinuma; Kazuhiro Irie; Toru Iwaki; Noriaki Kinoshita; Yutaka Kiyohara; Frank M LaFerla; Kazuma Murakami; Norimichi Nakamura; Yasumasa Ohyagi; Nobutaka Sakae; Jun-ichi Kira
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.
Current Alzheimer research 2013;10(1):11-20.
2013: Rodrigo Medeiros; Meredith A Chabrier; Frank M LaFerla
Elucidating the triggers, progression, and effects of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S195-210.
2012: Kara M Neely Kayala; Ken C Walls; George D Dickinson; Kim N Green; Anet Minassian; Frank M LaFerla
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
Brain research 2012;1489():8-16.
2012: Ayumi Takamura; Daisuke Watabe; Takeshi Kawarabayashi; Frank M LaFerla; Takashi Nakata; Salvatore Oddo; Yasuhide Okamoto; Yota Sato; Mikio Shoji; Etsuro Matsubara
Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways.
Life sciences 2012;91(23-24):1177-86.
2012: Meredith A Chabrier; Andranik A Agazaryan; Mathew Blurton-Jones; Hilda Martinez-Coria; Joy L Nerhus; Frank M LaFerla
Soluble aβ promotes wild-type tau pathology in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(48):17345-50.
2012: Frank M LaFerla; Kim N Green
Animal models of Alzheimer disease.
Cold Spring Harbor perspectives in medicine 2012;2(11):.
2012: Balu Chakravarthy; Ilaria Dal Prà; Chantal Gaudet; Shingo Ito; Frank M LaFerla; Michel Ménard; Ubaldo Armato; Trevor Atkinson; Leslie Brown; James Whitfield
Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau.
Biochemical and biophysical research communications 2012;427(1):218-22.
2012: Ken Carlson Walls; Nineli Zadourian; Suhail Rasool; Mathew Blurton-Jones; Pinar Coskun; Kristine Freude; Jose-Luis Gallegos-Perez; Kim N Green; Frank M LaFerla
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
The Journal of biological chemistry 2012;287(36):30317-27.
2012: Frank M LaFerla
Preclinical success against Alzheimer's disease with an old drug.
The New England journal of medicine 2012;367(6):570-2.
2012: Rodrigo Medeiros; Achim Moeller; David Baglietto-Vargas; Meredith A Chabrier; David Cheng; Kim N Green; Masashi Kitazawa; Andreas Kling; Frank M LaFerla
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology 2012;181(2):616-25.
2012: Tommaso Cassano; Silvia Cianci; Vincenzo Cuomo; Pasqua Dipasquale; Silvana Gaetani; Leonardo Laconca; Frank M LaFerla; Ferdinando Nicoletti; Iolanda Padalino; Adele Romano; Antonino Davide Romano; gaetano serviddio; Francesco Bellanti; Gianluigi Vendemiale
Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease.
Neurobiology of aging 2012;33(6):1121.e1-12.
2012: Eva Alonso; Haruhiko Fuwa; Lydia Giménez-Llort; Tomomi Goto; Yu Konno; Frank M LaFerla; Makoto Sasaki; Yuto Suga; Carmen Vale; Mercedes R Vieytes; Luis Botana
Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications.
Journal of the American Chemical Society 2012;134(17):7467-79.
2012: Yanxing Chen; Chun-Ling Dai; Inge Grundke-Iqbal; Khalid Iqbal; Frank M LaFerla; Moon H Lee; Zhihou Liang; Fei Liu; Shenggang Sun; Zhu Tian; Cheng-Xin Gong
Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease.
PloS one 2012;7(12):e51432.
2012: Xiao-Xin Yan; Gregory M Rose; Jarod Shelton; Huaibin Cai; Yan Cai; Si-Hao Deng; Frank M LaFerla; Xue-Gang Luo; Salvatore Oddo; Peter R Patrylo
Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice.
PloS one 2012;7(11):e48782.
2012: Kioko Guzmán-Ramos; Frank M LaFerla; Hilda Martínez-Coria; James L McGaugh; Perla Moreno-Castilla; Monica Castro-Cruz; Federico Bermúdez-Rattoni
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease.
Learning & memory (Cold Spring Harbor, N.Y.) 2012;19(10):453-60.
2012: Maya A Koike; Bernard Choi; Kim N Green; Alexander J Lin; Elaine Nguyen; Jonathan Pham; Rombod Rahimian; Bruce J Tromberg; James J Yeh; Frank M LaFerla
APP knockout mice experience acute mortality as the result of ischemia.
PloS one 2012;7(8):e42665.
2012: Nicholas A Castello; Kim N Green; Frank M LaFerla
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
PloS one 2012;7(8):e39566.
2012: M Teresa Girão da Cruz; Jessica Jordão; Frank M LaFerla; Joanne McLaurin; Ying-Qi Weng; Athéna Ypsilanti; Carlos A Ayala-Grosso; Kevin A DaSilva; Isabelle Aubert
Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice.
Journal of Alzheimer's disease : JAD 2012;32(2):267-72.
2012: Masashi Kitazawa; Rodrigo Medeiros; Frank M LaFerla
Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions.
Current pharmaceutical design 2012;18(8):1131-47.
2011: Eva Alonso; Lydia Giménez-Llort; Frank M LaFerla; Carmen Vale; Mercedes R Vieytes; Luis Botana
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Neurochemistry international 2011;59(7):1056-65.
2011: Tommaso Cassano; Concetta Stefania Cimmino; Roberto Colangeli; Vincenzo Cuomo; Frank M LaFerla; Teresa Macheda; Antonio Petrella; Adele Romano; Silvana Gaetani
Olfactory memory is impaired in a triple transgenic model of Alzheimer disease.
Behavioural brain research 2011;224(2):408-12.
2011: Rodrigo Medeiros; David Baglietto-Vargas; Frank M LaFerla
The role of tau in Alzheimer's disease and related disorders.
CNS neuroscience & therapeutics 2011;17(5):514-24.
2011: Junxia X Tang; Shannon L Bianchi; Breanna M Caltagarone; Roderic G Eckenhoff; Sean T Garrity; Olubusola Gomes; Frank M LaFerla; Rosie Q Li; Feras Mardini; Maryellen F Eckenhoff
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(5):521-531.e1.
2011: Kristine K Freude; Frank M LaFerla; Mahmud Penjwini; Joy L Davis; Mathew Blurton-Jones
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
The Journal of biological chemistry 2011;286(27):24264-74.
2011: Hien T Tran; David M Holtzman; Frank M LaFerla; David L Brody
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(26):9513-25.
2011: Michael Sy; Masashi Kitazawa; Rodrigo Medeiros; Lucia Whitman; David Cheng; Thomas E Lane; Frank M LaFerla
Inflammation induced by infection potentiates tau pathological features in transgenic mice.
The American journal of pathology 2011;178(6):2811-22.
2011: Kim N Green; Hasan Khashwji; Tatiana Estrada; Frank M LaFerla
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Annals of neurology 2011;69(5):831-44.
2011: Dominique Garin; Fatima Oukhatar; Andrew B Mahon; Andrew C Try; Michel Dubois-Dauphin; Frank M LaFerla; Martine Demeunynck; Marcelle Moulin Sallanon; Sabine Chierici
Proflavine derivatives as fluorescent imaging agents of amyloid deposits.
Bioorganic & medicinal chemistry letters 2011;21(8):2203-6.
2011: Alexander J Lin; Maya A Koike; Kim N Green; Jae G Kim; Amaan Mazhar; Tyler B Rice; Frank M LaFerla; Bruce J Tromberg
Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's disease.
Annals of biomedical engineering 2011;39(4):1349-57.
2011: Jose L Chou; Deepa V Shenoy; Nicy Thomas; Pankaj K Choudhary; Frank M LaFerla; Steven R Goodman; Gail A M Breen
Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease.
Journal of proteomics 2011;74(4):466-79.
2011: Kara M Neely; Kim N Green; Frank M LaFerla
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(8):2781-91.
2011: Federico T Bianchi; Enrica Boda; Ylenia Bosio; Paola Camera; Carlos G Dotti; Daniele Imperiale; Frank M LaFerla; antonio migheli; Salvatore Oddo; Stefano Taraglio; Filippo Tempia; Ugo Ala; Gaia Berto; Ferdinando Di Cunto
The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides.
PloS one 2011;6(7):e22370.
2011: Eva Alonso; Lydia Giménez-Llort; Frank M LaFerla; Carmen Vale; Mercedes R Vieytes; Luis Botana
The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(6):783-94.
2011: Yoelvis García-Mesa; Juan Carlos López-Ramos; Lydia Giménez-Llort; Susana Revilla; Rafa Guerra Narbona; Agnès Gruart; Frank M LaFerla; Rosa Cristòfol; José M Delgado-García; Coral Sanfeliu
Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.
Journal of Alzheimer's disease : JAD 2011;24(3):421-54.
2010: Alexander Shtifman; Christopher Ward; Derek R Laver; Mark L Bannister; Jose R Lopez; Masashi Kitazawa; Frank M LaFerla; Noriaki Ikemoto; Henry Querfurth
Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.
Neurobiology of aging 2010;31(12):2080-90.
2010: Julie Blanchard; Lukas Wanka; Yunn-Chyn Tung; María del Carmen Cárdenas-Aguayo; Frank M LaFerla; Khalid Iqbal; Inge Grundke-Iqbal
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Acta neuropathologica 2010;120(5):605-21.
2010: Roxanne Sterniczuk; Michael Antle; Frank M LaFerla; Richard H Dyck
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes.
Brain research 2010;1348():149-55.
2010: Roxanne Sterniczuk; Richard H Dyck; Frank M LaFerla; Michael Antle
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes.
Brain research 2010;1348():139-48.
2010: Rachel M Nicholson; Yael Kusne; Lee A Nowak; Frank M LaFerla; Eric Reiman; Jon Valla
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Brain research 2010;1347():179-85.
2010: Frank M LaFerla
Pathways linking Abeta and tau pathologies.
Biochemical Society transactions 2010;38(4):993-5.
2010: Maya A Koike; Kim N Green; Mathew Blurton-Jones; Frank M LaFerla
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology 2010;177(1):300-10.
2010: Lani K Clinton; Mathew Blurton-Jones; Kristoffer Myczek; John Q Trojanowski; Frank M LaFerla
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(21):7281-9.
2010: Judit España; Lydia Giménez-Llort; Jorge Valero; Alfredo Miñano; Alberto Rábano; José Rodriguez-Alvarez; Frank M LaFerla; Carlos A Saura
Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
Biological psychiatry 2010;67(6):513-21.
2010: Hilda Martinez-Coria; Kim N Green; Lauren M Billings; Masashi Kitazawa; Miriam Albrecht; Gerhard Rammes; Chris G Parsons; Sandeep Gupta; Pradeep Banerjee; Frank M LaFerla
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology 2010;176(2):870-80.
2010: Henry Querfurth; Frank M LaFerla
Alzheimer's disease.
The New England journal of medicine 2010;362(4):329-44.
2010: Tobias Bittner; Martin Fuhrmann; Steffen Burgold; Simon M Ochs; Nadine Hoffmann; Gerda Mitteregger; Hans A Kretzschmar; Frank M LaFerla; Jochen Herms
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
PloS one 2010;5(11):e15477.
2010: Anna Parachikova; Kim N Green; Curt Hendrix; Frank M LaFerla
Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
PloS one 2010;5(11):e14015.
2010: Anna Parachikova; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla; Kim N Green
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD 2010;21(2):527-42.
2009: Leslie Michels Thompson; Charity T Aiken; Linda S Kaltenbach; Namita Agrawal; Katalin Illes; Ali Khoshnan; Marta Martinez-Vincente; Montserrat Arrasate; Jacqueline Gire O'Rourke; Hasan Khashwji; Tamas Lukacsovich; Ya-Zhen Zhu; Alice L Lau; Ashish Massey; Michael R Hayden; Scott O Zeitlin; Steven Finkbeiner; Kim N Green; Frank M LaFerla; Gillian P Bates; Lan Huang; Paul H Patterson; Donald C Lo; Ana Maria Cuervo; J Lawrence Marsh; Joan S Steffan
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
The Journal of cell biology 2009;187(7):1083-99.
2009: Richard T Robertson; Janie Baratta; Jen Yu; Frank M LaFerla
Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.
Neuroscience 2009;164(3):1334-46.
2009: Melissa Ouellet; Vincent Emond; Chuck T Chen; Carl Julien; Fanchon Bourasset; Salvatore Oddo; Frank M LaFerla; Richard P Bazinet; Frederic Calon
Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.
Neurochemistry international 2009;55(7):476-82.
2009: Mathew Blurton-Jones; Masashi Kitazawa; Hilda Martinez-Coria; Nicholas A Castello; Franz-Josef Müller; Jeanne F Loring; Tritia R Yamasaki; Wayne W Poon; Kim N Green; Frank M LaFerla
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13594-9.
2009: Maria I Fonseca; Rahasson R Ager; Shu-Hui Chu; Ozkan Yazan; Sam D Sanderson; Frank M LaFerla; Stephen M Taylor; Trent M Woodruff; Andrea J Tenner
Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1375-83.
2009: Salvatore Oddo; Antonella Caccamo; David Cheng; Frank M LaFerla
Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology.
Brain pathology (Zurich, Switzerland) 2009;19(3):421-30.
2009: Masashi Kitazawa; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6132-41.
2009: Guan Hanjun; Yinxing Liu; Abigail Daily; Sara Police; Myung-Hee Kim; Salvatore Oddo; Frank M LaFerla; James R Pauly; Michael Murphy; Louis B Hersh
Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.
Journal of neuroscience research 2009;87(6):1462-73.
2009: Irene Knuesel; Myriel Nyffeler; Cecile Mormède; Mary Muhia; Urs Meyer; Susanna Pietropaolo; Benjamin Yee; Christopher R Pryce; Frank M LaFerla; Aline Marighetto; Joram Feldon
Age-related accumulation of Reelin in amyloid-like deposits.
Neurobiology of aging 2009;30(5):697-716.
2009: Antonella Caccamo; Abraham Fisher; Frank M LaFerla
M1 agonists as a potential disease-modifying therapy for Alzheimer's disease.
Current Alzheimer research 2009;6(2):112-7.
2009: Fiona E McAlpine; Jae-Kyung Lee; Ashley S Harms; Kelly A Ruhn; Mathew Blurton-Jones; John Hong; Pritam Das; todd golde; Frank M LaFerla; Salvatore Oddo; Armin Blesch; Malú G Tansey
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.
Neurobiology of disease 2009;34(1):163-77.
2009: Debbi A Morrissette; Anna Parachikova; Kim N Green; Frank M LaFerla
Relevance of transgenic mouse models to human Alzheimer disease.
The Journal of biological chemistry 2009;284(10):6033-7.
2009: Fanchon Bourasset; Cyntia Tremblay; Carl Julien; Tuan Minh Do; Salvatore Oddo; Frank M LaFerla; Mélissa Ouellet; Frederic Calon
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease.
Neuropharmacology 2009;56(4):808-13.
2009: Masashi Kitazawa; David Cheng; Frank M LaFerla
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD.
Journal of neurochemistry 2009;108(6):1550-60.
2009: Maria Gulinello; Michael Gertner; Guadalupe Mendoza; Brian P Schoenfeld; Salvatore Oddo; Frank M LaFerla; Catherine H Choi; Sean M J McBride; Donald S Faber
Validation of a 2-day water maze protocol in mice.
Behavioural brain research 2009;196(2):220-7.
2009: Joao P Lopes; Mathew Blurton-Jones; Tritia R Yamasaki; Paula M.G. Agostinho; Frank M LaFerla
Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.
Journal of Alzheimer's disease : JAD 2009;16(3):541-9.
2009: Paworn Nuntagij; Salvatore Oddo; Frank M LaFerla; Naiphinich Kotchabhakdi; Ole P Ottersen; Reidun Torp
Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines.
Journal of Alzheimer's disease : JAD 2009;16(2):315-23.
2008: Michelle C Janelsins; Michael A Mastrangelo; Keigan M Park; Kelly L Sudol; Wade C Narrow; Salvatore Oddo; Frank M LaFerla; Linda M Callahan; Howard Federoff; William J Bowers
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
The American journal of pathology 2008;173(6):1768-82.
2008: Salvatore Oddo; Antonella Caccamo; Bert Tseng; David Cheng; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12163-75.
2008: Kim N Green; Joan S Steffan; Hilda Martinez-Coria; Xuemin Sun; Steven S. Schreiber; Leslie Michels Thompson; Frank M LaFerla
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11500-10.
2008: Bertrand P Tseng; Kim N Green; Julie L Chan; Mathew Blurton-Jones; Frank M LaFerla
Abeta inhibits the proteasome and enhances amyloid and tau accumulation.
Neurobiology of aging 2008;29(11):1607-18.
2008: Kim N Green; Angelo Demuro; Yama Akbari; Brian D Hitt; Ian F Smith; Ian Parker; Frank M LaFerla
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
The Journal of general physiology 2008;132(2):i1.
2008: Kim N Green; Frank M LaFerla
Linking calcium to Abeta and Alzheimer's disease.
Neuron 2008;59(2):190-4.
2008: Masashi Kitazawa; Dan N Trinh; Frank M LaFerla
Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta.
Annals of neurology 2008;64(1):15-24.
2008: Kim N Green; Angelo Demuro; Yama Akbari; Brian D Hitt; Ian F Smith; Ian Parker; Frank M LaFerla
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
The Journal of cell biology 2008;181(7):1107-16.
2008: Chiho Hirata-Fukae; Hui-Fang Li; Hyang-Sook Hoe; Audrey J Gray; S Sakura Minami; Katsuyoshi Hamada; Takako Niikura; Fang Hua; Hiroe Tsukagoshi-Nagai; Yuko Horikoshi-Sakuraba; Mohamed Mughal; G. William Rebeck; Frank M LaFerla; Mark P Mattson; Nobuhisa Iwata; Takaomi C Saido; William L Klein; karen duff; Paul S Aisen; Yasuji Matsuoka
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Brain research 2008;1216():92-103.
2008: Ann McKee; Isabel Carreras; Lokman Hossain; Hoon Ryu; William L Klein; Salvatore Oddo; Frank M LaFerla; Bruce G Jenkins; Neil W Kowall; Alpaslan Dedeoglu
Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
Brain research 2008;1207():225-36.
2008: José R Lopez; Alvin Lyckman; Salvatore Oddo; Frank M LaFerla; Henry Querfurth; Alexander Shtifman
Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.
Journal of neurochemistry 2008;105(1):262-71.
2008: José J Rodríguez; Victoria C Jones; Masashi Tabuchi; Stuart M Allan; Elysse M Knight; Frank M LaFerla; Salvatore Oddo; Alexei Verkhratsky
Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease.
PloS one 2008;3(8):e2935.
2008: Izumi Maezawa; Hyun-Seok Hong; Ruiwu Liu; Chun-Yi Wu; R Holland Cheng; Mei-Ping Kung; Hank F Kung; Kit S Lam; Salvatore Oddo; Frank M LaFerla; Lee-Way Jin
Congo red and thioflavin-T analogs detect Abeta oligomers.
Journal of neurochemistry 2008;104(2):457-68.
2007: Jenna C Carroll; Emily R Rosario; Lilly Chang; Frank Z Stanczyk; Salvatore Oddo; Frank M LaFerla; Christian J Pike
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13357-65.
2007: Kazuyuki Takata; Chiho Hirata-Fukae; Amanda Becker; Saori Chishiro; Audrey J Gray; Kouhei Nishitomi; Andreas H Franz; Gaku Sakaguchi; Akira Kato; Mark P Mattson; Frank M LaFerla; Paul S Aisen; Yoshihisa Kitamura; Yasuji Matsuoka
Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.
The European journal of neuroscience 2007;26(9):2458-68.
2007: Adam R Cole; Wendy Noble; Lidy van Aalten; Florian Plattner; Rena Meimaridou; Dale Hogan; Margaret Taylor; John LaFrancois; Frank J Gunn-Moore; Alexei Verkhratsky; Salvatore Oddo; Frank M LaFerla; peter giese; Kelly T Dineley; karen duff; Jill C Richardson; Shi Du Yan; Diane P Hanger; Stuart M Allan; Calum Sutherland
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
Journal of neurochemistry 2007;103(3):1132-44.
2007: Tritia R Yamasaki; Mathew Blurton-Jones; Debbi A Morrissette; Masashi Kitazawa; Salvatore Oddo; Frank M LaFerla
Neural stem cells improve memory in an inducible mouse model of neuronal loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):11925-33.
2007: Lani K Clinton; Lauren M Billings; Kim N Green; Antonella Caccamo; Jerry Ngo; Salvatore Oddo; James L McGaugh; Frank M LaFerla
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice.
Neurobiology of disease 2007;28(1):76-82.
2007: Salvatore Oddo; Antonella Caccamo; David Cheng; Bahareh Jouleh; Reidun Torp; Frank M LaFerla
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Journal of neurochemistry 2007;102(4):1053-63.
2007: Frank M LaFerla; Kim N Green; Salvatore Oddo
Intracellular amyloid-beta in Alzheimer's disease.
Nature reviews. Neuroscience 2007;8(7):499-509.
2007: Antonella Caccamo; Salvatore Oddo; Lana X Tran; Frank M LaFerla
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
The American journal of pathology 2007;170(5):1669-75.
2007: Kim N Green; Hilda Martinez-Coria; Hasan Khashwji; Eileen B Hall; Karin A Yurko-Mauro; Lorie Ellis; Frank M LaFerla
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4385-95.
2007: Veerendra Kumar Madala Halagappa; Zhihong Guo; Michelle Pearson; Yasuji Matsuoka; Roy G Cutler; Frank M LaFerla; Mark P Mattson
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2007;26(1):212-20.
2007: Grace E Stutzmann; Ian Smith; Antonella Caccamo; Salvatore Oddo; Ian Parker; Frank M LaFerla
Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models.
Annals of the New York Academy of Sciences 2007;1097():265-77.
2007: Lauren M Billings; Kim N Green; James L McGaugh; Frank M LaFerla
Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):751-61.
2007: Kim N Green; Ian F Smith; Frank M LaFerla
Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models.
Sub-cellular biochemistry 2007;45():507-21.
2007: Yasuji Matsuoka; Audrey J Gray; Chiho Hirata-Fukae; S Sakura Minami; Emily Graeme Waterhouse; Mark P Mattson; Frank M LaFerla; Illana Gozes; Paul S Aisen
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.
Journal of molecular neuroscience : MN 2007;31(2):165-70.
2007: Lydia Giménez-Llort; G Blázquez; Toni Cañete; Björn Johansson; Salvatore Oddo; Adolf Tobeña; Frank M LaFerla; Alberto Fernández-Teruel
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid.
Neuroscience and biobehavioral reviews 2007;31(1):125-47.
2006: Salvatore Oddo; Vitaly Vasilevko; Antonella Caccamo; Masashi Kitazawa; David H Cribbs; Frank M LaFerla
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
The Journal of biological chemistry 2006;281(51):39413-23.
2006: Emily R Rosario; Jenna C Carroll; Salvatore Oddo; Frank M LaFerla; Christian J Pike
Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(51):13384-9.
2006: Mathew Blurton-Jones; Frank M LaFerla
Pathways by which Abeta facilitates tau pathology.
Current Alzheimer research 2006;3(5):437-48.
2006: Charbel E-H Moussa; Qinghao Fu; Pravir Kumar; Alexander Shtifman; Jose R Lopez; Paul D Allen; Frank M LaFerla; David Weinberg; Jordi Magrane; Tamar Aprahamian; Kenneth Walsh; Kenneth M Rosen; Henry Querfurth
Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2165-7.
2006: Kim N Green; Lauren M Billings; Benno Roozendaal; James L McGaugh; Frank M LaFerla
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(35):9047-56.
2006: Frank M LaFerla
An array of genes implicated in Alzheimer's disease.
Neurobiology of aging 2006;27(8):1078-80.
2006: Lorena Heredia; Pablo Helguera; Soledad De Olmos; Gabriela Kedikian; Francisco Solá Vigo; Frank M LaFerla; Matthias Staufenbiel; José de Olmos; Jorge Busciglio; Alfredo Cáceres; Alfredo Lorenzo
Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6533-42.
2006: Masashi Kitazawa; Kim N Green; Antonella Caccamo; Frank M LaFerla
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
The American journal of pathology 2006;168(6):1986-97.
2006: Grace E Stutzmann; Ian Smith; Antonella Caccamo; Salvatore Oddo; Frank M LaFerla; Ian Parker
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):5180-9.
2006: Antonella Caccamo; Salvatore Oddo; Lauren M Billings; Kim N Green; Hilda Martinez-Coria; Abraham Fisher; Frank M LaFerla
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Neuron 2006;49(5):671-82.
2006: Salvatore Oddo; Frank M LaFerla
The role of nicotinic acetylcholine receptors in Alzheimer's disease.
Journal of physiology, Paris 2006;99(2-3):172-9.
2006: Michael C Sugarman; Masashi Kitazawa; Michael Baker; Vincent J Caiozzo; Henry Querfurth; Frank M LaFerla
Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model.
Neurobiology of aging 2006;27(3):423-32.
2006: Salvatore Oddo; Antonella Caccamo; Levina Tran; Mary P Lambert; Charles G Glabe; William L Klein; Frank M LaFerla
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.
The Journal of biological chemistry 2006;281(3):1599-604.
2006: Salvatore Oddo; Antonella Caccamo; Ian F Smith; Kim N Green; Frank M LaFerla
A dynamic relationship between intracellular and extracellular pools of Abeta.
The American journal of pathology 2006;168(1):184-94.
2005: Frank M LaFerla; Masashi Kitazawa
Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad.
Neuron 2005;48(5):711-2.
2005: Michelle C Janelsins; Michael A Mastrangelo; Salvatore Oddo; Frank M LaFerla; Howard Federoff; William J Bowers
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.
Journal of neuroinflammation 2005;2():23.
2005: Masashi Kitazawa; Salvatore Oddo; Tritia R Yamasaki; Kim N Green; Frank M LaFerla
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(39):8843-53.
2005: Ian F Smith; Brian Hitt; Kim N Green; Salvatore Oddo; Frank M LaFerla
Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease.
Journal of neurochemistry 2005;94(6):1711-8.
2005: Ian F Smith; Kim N Green; Frank M LaFerla
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.
Cell calcium 2005;38(3-4):427-37.
2005: Antonella Caccamo; Salvatore Oddo; Michael C Sugarman; Yama Akbari; Frank M LaFerla
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.
Neurobiology of aging 2005;26(5):645-54.
2005: Frank M LaFerla; Salvatore Oddo
Alzheimer's disease: Abeta, tau and synaptic dysfunction.
Trends in molecular medicine 2005;11(4):170-6.
2005: Lauren M Billings; Salvatore Oddo; Kim N Green; James L McGaugh; Frank M LaFerla
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice.
Neuron 2005;45(5):675-88.
2005: Salvatore Oddo; Antonella Caccamo; Kim N Green; Kevin Liang; Levina Tran; Yiling Chen; Frances M Leslie; Frank M LaFerla
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3046-51.
2004: Masashi Kitazawa; Tritia R Yamasaki; Frank M LaFerla
Microglia as a potential bridge between the amyloid beta-peptide and tau.
Annals of the New York Academy of Sciences 2004;1035():85-103.
2004: Bertrand P Tseng; Masashi Kitazawa; Frank M LaFerla
Amyloid beta-peptide: the inside story.
Current Alzheimer research 2004;1(4):231-9.
2004: Yama Akbari; Brian D Hitt; Michael Murphy; Nabil N Dagher; Bertrand P Tseng; Kim N Green; todd golde; Frank M LaFerla
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
Biochemical and biophysical research communications 2004;322(4):1145-52.
2004: Salvatore Oddo; Lauren M Billings; J Patrick Kesslak; David H Cribbs; Frank M LaFerla
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.
Neuron 2004;43(3):321-32.
2004: Robert A Rissman; Wayne W Poon; Mathew Blurton-Jones; Salvatore Oddo; Reidun Torp; Michael P. Vitek; Frank M LaFerla; Troy T Rohn; Carl W Cotman
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
The Journal of clinical investigation 2004;114(1):121-30.
2004: Glenda Bishop; Paul D. Coleman; keith crutcher; Della David; June Kinoshita; Frank M LaFerla; Malcolm Leissring; Jason Shepherd; Stavros Therianos; Rong Wang; Andrea Wilson; Min Zhu
Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain.
Journal of Alzheimer's disease : JAD 2004;6(2):193-9.
2004: Vikram Shakkottai; Chin-hua Chou; Salvatore Oddo; Claudia A Sailer; Hans-Günther Knaus; George A Gutman; Michael E Barish; Frank M LaFerla; K George Chandy
Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.
The Journal of clinical investigation 2004;113(4):582-90.
2004: Grace E Stutzmann; Antonella Caccamo; Frank M LaFerla; Ian Parker
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(2):508-13.
2003: Salvatore Oddo; Antonella Caccamo; Masashi Kitazawa; Bertrand P Tseng; Frank M LaFerla
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.
Neurobiology of aging 2003;24(8):1063-70.
2003: Salvatore Oddo; Antonella Caccamo; Jason D Shepherd; Michael Murphy; todd golde; Rakez Kayed; Raju Metherate; Mark P Mattson; Yama Akbari; Frank M LaFerla
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
Neuron 2003;39(3):409-21.
2003: Grace E Stutzmann; Frank M LaFerla; Ian Parker
Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(3):758-65.
2002: Frank M LaFerla
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
Nature reviews. Neuroscience 2002;3(11):862-72.
2002: Michael C Sugarman; Tritia R Yamasaki; Salvatore Oddo; Julio C Echegoyen; Michael Murphy; todd golde; Mehrdad Jannatipour; Malcolm Leissring; Frank M LaFerla
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6334-9.
2002: Malcolm Leissring; Michael Murphy; Tonya R Mead; Yama Akbari; Michael C Sugarman; Mehrdad Jannatipour; Brigitte Anliker; Ulrike Müller; Paul Saftig; Bart De Strooper; Michael S Wolfe; todd golde; Frank M LaFerla
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2001: Jonathan Marchant; Grace E Stutzmann; Malcolm Leissring; Frank M LaFerla; Ian Parker
Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling.
Nature biotechnology 2001;19(7):645-9.
2001: Malcolm Leissring; Frank M LaFerla; N Callamaras; Ian Parker
Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling.
Neurobiology of disease 2001;8(3):469-78.
2000: Frank M LaFerla; Michael C Sugarman; T E Lane; Malcolm Leissring
Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma.
Journal of molecular neuroscience : MN 2000;15(1):45-59.
2000: Malcolm Leissring; T R Yamasaki; Wilma Wasco; Joseph Buxbaum; Ian Parker; Frank M LaFerla
Calsenilin reverses presenilin-mediated enhancement of calcium signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8590-3.
2000: David H Cribbs; BY Azizeh; Carl W Cotman; Frank M LaFerla
Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide.
Biochemistry 2000;39(20):5988-94.
2000: Malcolm Leissring; Yama Akbari; CM Fanger; Michael D Cahalan; Mark P Mattson; Frank M LaFerla
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.
The Journal of cell biology 2000;149(4):793-8.
2000: Mark P Mattson; Frank M LaFerla; S L Chan; Malcolm Leissring; P Nickolas Shepel; Jonathan D Geiger
Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders.
Trends in neurosciences 2000;23(5):222-9.
1999: Malcolm Leissring; Ian Parker; Frank M LaFerla
Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals.
The Journal of biological chemistry 1999;274(46):32535-8.
1999: Malcolm Leissring; B A Paul; Ian Parker; Carl W Cotman; Frank M LaFerla
Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes.
Journal of neurochemistry 1999;72(3):1061-8.
1998: Malcolm Leissring; Michael C Sugarman; Frank M LaFerla
Herpes simplex virus infections and Alzheimer's disease. Implications for drug treatment and immunotherapy.
Drugs & aging 1998;13(3):193-8.
1997: Frank M LaFerla; Juan C Troncoso; Dudley K Strickland; C H Kawas; G Jay
Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.
The Journal of clinical investigation 1997;100(2):310-20.
1997: L L Weber; Malcolm Leissring; Austin Yang; Charles G Glabe; David H Cribbs; Frank M LaFerla
Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques.
Experimental neurology 1997;143(1):37-44.
1996: Frank M LaFerla; C K Hall; L Ngo; G Jay
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.
The Journal of clinical investigation 1996;98(7):1626-32.
1996: David H Cribbs; L S Chen; Carl W Cotman; Frank M LaFerla
Injury induces presenilin-1 gene expression in mouse brain.
Neuroreport 1996;7(11):1773-6.
1996: David H Cribbs; L S Chen; S M Bende; Frank M LaFerla
Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.
The American journal of pathology 1996;148(6):1797-806.
1995: Frank M LaFerla; B T Tinkle; Charles J Bieberich; Christian Haudenschild; G Jay
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.
Nature genetics 1995;9(1):21-30.