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Sylvia Laffer

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Gernot Sellge; Sylvia Laffer; CT Mierke; Susanne Vrtala; M W Hoffmann; Jürgen Klempnauer; Michael P Manns; Rudolf Valenta; Stephan C Bischoff
Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reactions.
Ashok Purohit; Sylvia Laffer; Carine Metz-Favre; A Verot; F Kricek; Rudolf Valenta; Gabrielle Pauli
Poor association between allergen-specific serum immunoglobulin E levels, skin sensitivity and basophil degranulation: a study with recombinant birch pollen allergen Bet v 1 and an immunoglobulin E detection system measuring immunoglobulin E capable of binding to Fc epsilon RI.
Sylvia Laffer; Said Hamdi; Christian Lupinek; Wolfgang R Sperr; Peter Valent; Petra Verdino; Walter Keller; Monika Grote; Karin Hoffmann-Sommergruber; Otto Scheiner; Dietrich Kraft; Marc Rideau; Rudolf Valenta
Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family.

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All Publications

2005: Gernot Sellge; Sylvia Laffer; CT Mierke; Susanne Vrtala; M W Hoffmann; Jürgen Klempnauer; Michael P Manns; Rudolf Valenta; Stephan C Bischoff
Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(6):774-81.
2005: Ashok Purohit; Sylvia Laffer; Carine Metz-Favre; A Verot; F Kricek; Rudolf Valenta; Gabrielle Pauli
Poor association between allergen-specific serum immunoglobulin E levels, skin sensitivity and basophil degranulation: a study with recombinant birch pollen allergen Bet v 1 and an immunoglobulin E detection system measuring immunoglobulin E capable of binding to Fc epsilon RI.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(2):186-92.
2003: Sylvia Laffer; Said Hamdi; Christian Lupinek; Wolfgang R Sperr; Peter Valent; Petra Verdino; Walter Keller; Monika Grote; Karin Hoffmann-Sommergruber; Otto Scheiner; Dietrich Kraft; Marc Rideau; Rudolf Valenta
Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family.
The Biochemical journal 2003;373(Pt 1):261-9.
2003: Christian Harwanegg; Sylvia Laffer; Reinhard Hiller; Manfred Mueller; Dietrich Kraft; Susanne Spitzauer; Rudolf Valenta
Microarrayed recombinant allergens for diagnosis of allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(1):7-13.
2001: Sylvia Laffer; E Hogbom; K H Roux; Wolfgang R Sperr; Peter Valent; Hans C Bankl; Luca Vangelista; F Kricek; Dietrich Kraft; Hans Grönlund; Rudolf Valenta
A molecular model of type I allergy: identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FcepsilonRI interaction and reacts with receptor-bound IgE.
The Journal of allergy and clinical immunology 2001;108(3):409-16.
2001: Sylvia Laffer; Peter Steinberger; Dietrich Kraft; Rudolf Valenta
Promiscuous use of light chains by human IgE antibodies specific for three major grass pollen allergens.
International archives of allergy and immunology 2001;124(1-3):29-30.
2000: Sabine Flicker; Sylvia Laffer; Peter Steinberger; B Alhani; Y Zhu; ML Laukkanen; Kari Keinänen; Dietrich Kraft; Rudolf Valenta
Engineering, purification and applications of His-tagged recombinant antibody fragments with specificity for the major birch pollen allergen, bet v1.
Biological chemistry 2000;381(1):39-47.
1999: Luca Vangelista; Sylvia Laffer; R Turek; Hans Grönlund; Wolfgang R Sperr; Peter Valent; A Pastore; Rudolf Valenta
The immunoglobulin-like modules Cepsilon3 and alpha2 are the minimal units necessary for human IgE-FcepsilonRI interaction.
The Journal of clinical investigation 1999;103(11):1571-8.
1999: Verena Niederberger; Brigitte Hayek; Susanne Vrtala; Sylvia Laffer; Anna Twardosz; Luca Vangelista; Wolfgang R Sperr; Peter Valent; Helmut Rumpold; Dietrich Kraft; Klaus Ehrenberger; Rudolf Valenta; Susanne Spitzauer
Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):843-56.
1999: Sylvia Laffer; E Hogbom; J Adrianson; Hans Grönlund; Christian Sillaber; Peter Valent; Luca Vangelista; F Kricek; Dietrich Kraft; Rudolf Valenta
An in vitro model for the allergen-IgE-FcARI interaction.
International archives of allergy and immunology 1999;118(2-4):116-8.
1998: Rudolf Valenta; Steven C Almo; Tanja Ball; C Dolecek; Peter Steinberger; Sylvia Laffer; Petra Eibensteiner; Sabine Flicker; Susanne Vrtala; Susanne Spitzauer; Peter Valent; S Denepoux; Dietrich Kraft; Jacques Banchereau; Serge Lebecque
The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.
International archives of allergy and immunology 1998;116(3):167-76.
1998: Rudolf Valenta; Susanne Vrtala; Sylvia Laffer; Susanne Spitzauer; Dietrich Kraft
Recombinant allergens.
Allergy 1998;53(6):552-61.
1998: S Carpin; Sylvia Laffer; F Schoentgen; Rudolf Valenta; Jean-Claude Chénieux; Marc Rideau; Said Hamdi
Molecular characterization of a cytokinin-inducible periwinkle protein showing sequence homology with pathogenesis-related proteins and the Bet v 1 allergen family.
Plant molecular biology 1998;36(5):791-8.
1998: Verena Niederberger; Sylvia Laffer; R Fröschl; Dietrich Kraft; Helmut Rumpold; S Kapiotis; Rudolf Valenta; Susanne Spitzauer
IgE antibodies to recombinant pollen allergens (Phl p 1, Phl p 2, Phl p 5, and Bet v 2) account for a high percentage of grass pollen-specific IgE.
The Journal of allergy and clinical immunology 1998;101(2 Pt 1):258-64.
1997: Rudolf Valenta; Sabine Flicker; Petra Eibensteiner; Peter Steinberger; Sylvia Laffer; C Dolecek; Dietrich Kraft
Recombinant allergen-specific antibody fragments: tools for diagnosis, prevention and therapy of type I allergy.
Biological chemistry 1997;378(8):745-9.
1997: Sylvia Laffer; Luca Vangelista; Peter Steinberger; Dietrich Kraft; A Pastore; Rudolf Valenta
Bip 1, a monoclonal antibody with specificity for the major birch pollen allergen Bet v 1, modulates IgE binding to the allergen.
International archives of allergy and immunology 1997;113(1-3):260-1.
1997: Serge Lebecque; C Dolecek; Sylvia Laffer; V Visco; S Denépoux; Jean-Jacques Pin; Christiane Guret; G Boltz-Nitulescu; A Weyer; Rudolf Valenta
Immunologic characterization of monoclonal antibodies that modulate human IgE binding to the major birch pollen allergen Bet v 1.
The Journal of allergy and clinical immunology 1997;99(3):374-84.
1997: Rudolf Valenta; Peter Steinberger; Sylvia Laffer; C Dolecek; P Wiedemann; Sabine Flicker; Dietrich Kraft
Cloning allergen-specific antibody fragments (Fabs); tools for allergen standardization and therapy of type I allergy.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1997;(91):222-9.
1996: Sylvia Laffer; Luca Vangelista; Peter Steinberger; Dietrich Kraft; A Pastore; Rudolf Valenta
Molecular characterization of Bip 1, a monoclonal antibody that modulates IgE binding to birch pollen allergen, Bet v 1.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):4953-62.
1996: Sylvia Laffer; Susanne Spitzauer; M Susani; H Pairleitner; C Schweiger; Hans Grönlund; Günter Menz; Gabrielle Pauli; T Ishii; H Nolte; Christof Ebner; A H Sehon; Dietrich Kraft; Hans-Georg Eichler; Rudolf Valenta
Comparison of recombinant timothy grass pollen allergens with natural extract for diagnosis of grass pollen allergy in different populations.
The Journal of allergy and clinical immunology 1996;98(3):652-8.
1996: Sylvia Laffer; M Duchene; I Reimitzer; M Susani; C Mannhalter; Dietrich Kraft; Rudolf Valenta
Common IgE-epitopes of recombinant Phl p I, the major timothy grass pollen allergen and natural group I grass pollen isoallergens.
Molecular immunology 1996;33(4-5):417-26.
1996: Susanne Vrtala; M Susani; W R Sperr; Peter Valent; Sylvia Laffer; C Dolecek; Dietrich Kraft; Rudolf Valenta
Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phl p 1, Phl p2, Phl p 5).
The Journal of allergy and clinical immunology 1996;97(3):781-7.
1996: Rudolf Valenta; Sylvia Laffer; Susanne Vrtala; Hans Grönlund; Lena Elfman; W R Sperr; Peter Valent; Fatima Ferreira; P Mayer; E Liehl; S Heiss; R Steiner; Hans-Georg Eichler; M Susani; Dietrich Kraft
Recombinant allergens. Steps on the way to diagnosis and therapy of type I allergy.
Advances in experimental medicine and biology 1996;409():185-96.
1996: S Schenk; Heimo Breiteneder; M Susani; N Najafian; Sylvia Laffer; Michael Duchêne; Rudolf Valenta; G Fischer; Otto Scheiner; Dietrich Kraft; Christof Ebner
T cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense). Crossreactivity with group I allergens of different grasses.
Advances in experimental medicine and biology 1996;409():141-6.
1995: S Schenk; Heimo Breiteneder; M Susani; N Najafian; Sylvia Laffer; Michael Duchêne; Rudolf Valenta; G Fischer; Otto Scheiner; Dietrich Kraft
T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens.
The Journal of allergy and clinical immunology 1995;96(6 Pt 1):986-96.
1994: Sylvia Laffer; Rudolf Valenta; Susanne Vrtala; M Susani; R van Ree; Dietrich Kraft; Otto Scheiner; Michael Duchêne
Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species.
The Journal of allergy and clinical immunology 1994;94(4):689-98.
1994: Sylvia Laffer; Susanne Vrtala; Michael Duchêne; R van Ree; Dietrich Kraft; Otto Scheiner; Rudolf Valenta
IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens.
The Journal of allergy and clinical immunology 1994;94(1):88-94.
1994: Rudolf Valenta; Susanne Vrtala; Sylvia Laffer; Peter Steinberger; Tanja Ball; Fatima Ferreira; Otto Scheiner; Dietrich Kraft
B-cell epitopes of allergens determined by recombinant techniques; use for diagnosis and therapy of type I allergy.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1994;(87):235-46.
1993: C Dolecek; Susanne Vrtala; Sylvia Laffer; Peter Steinberger; Dietrich Kraft; Otto Scheiner; Rudolf Valenta
Molecular characterization of Phl p II, a major timothy grass (Phleum pratense) pollen allergen.
FEBS letters 1993;335(3):299-304.
1993: Susanne Vrtala; W R Sperr; I Reimitzer; R van Ree; Sylvia Laffer; WD Müller; Peter Valent; Klaus Lechner; Helmut Rumpold; Dietrich Kraft
cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl pV allergen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4773-81.
1993: Rudolf Valenta; Peter Steinberger; Susanne Vrtala; Monika Grote; Sylvia Laffer; W R Sperr; Peter Valent; Dietrich Kraft; Otto Scheiner
[New concepts in therapy of type I allergic diseases].
Wiener klinische Wochenschrift 1993;105(23):682-6.