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Bryan Laffitte

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Sarah Hummasti; Bryan A Laffitte; Michael A Watson; Cristin Galardi; Lily C Chao; Lakshman Ramamurthy; John T Moore; Peter Tontonoz
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.
Robert Walczak; Sean B Joseph; Bryan A Laffitte; Antonio Castrillo; Liming Pei; Peter Tontonoz
Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.
Bryan A Laffitte; Lily C Chao; Jing Li; Robert Walczak; Sarah Hummasti; Sean B Joseph; Antonio Castrillo; DAMIEN WILPITZ; David J Mangelsdorf; Jon L Collins; Enrique Saez; Peter Tontonoz
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.

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All Publications

2004: Sarah Hummasti; Bryan A Laffitte; Michael A Watson; Cristin Galardi; Lily C Chao; Lakshman Ramamurthy; John T Moore; Peter Tontonoz
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.
Journal of lipid research 2004;45(4):616-25.
2004: Robert Walczak; Sean B Joseph; Bryan A Laffitte; Antonio Castrillo; Liming Pei; Peter Tontonoz
Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.
The Journal of biological chemistry 2004;279(11):9905-11.
2003: Bryan A Laffitte; Lily C Chao; Jing Li; Robert Walczak; Sarah Hummasti; Sean B Joseph; Antonio Castrillo; DAMIEN WILPITZ; David J Mangelsdorf; Jon L Collins; Enrique Saez; Peter Tontonoz
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5419-24.
2003: Bryan A Laffitte; Sean B Joseph; Mingyi Chen; Antonio Castrillo; Joyce J Repa; DAMIEN WILPITZ; David Mangelsdorf; Peter Tontonoz
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Molecular and cellular biology 2003;23(6):2182-91.
2003: Sean B Joseph; Antonio Castrillo; Bryan A Laffitte; David J Mangelsdorf; Peter Tontonoz
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nature medicine 2003;9(2):213-9.
2002: Rajendra K Tangirala; Eric D Bischoff; Sean B Joseph; Brandee L Wagner; Robert Walczak; Bryan A Laffitte; Chris L Daige; Diane Thomas; Richard A Heyman; David J Mangelsdorf; Xuping Wang; Aldons J Lusis; Peter Tontonoz; Ira G Schulman
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
2002: Puiying A Mak; Bryan A Laffitte; Catherine Desrumaux; Sean B Joseph; Linda K Curtiss; David J Mangelsdorf; Peter Tontonoz; Peter A Edwards
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
2002: Sean B Joseph; Elaine McKilligin; Liming Pei; Michael A Watson; Alan R Collins; Bryan A Laffitte; Mingyi Chen; Grace Noh; Joanne Goodman; Graham N Hagger; Jonathan Tran; Timothy K Tippin; Xuping Wang; Aldons J Lusis; Willa A Hsueh; Ronald E Law; Jon L Collins; Timothy M Willson; Peter Tontonoz
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7604-9.
2002: Bryan A Laffitte; Peter Tontonoz
Orphan nuclear receptors find a home in the arterial wall.
Current atherosclerosis reports 2002;4(3):213-21.
2002: Sean B Joseph; Bryan A Laffitte; Parthive H Patel; Michael A Watson; Karen E Matsukuma; Robert Walczak; Jon L Collins; Timothy F Osborne; Peter Tontonoz
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.
The Journal of biological chemistry 2002;277(13):11019-25.
2001: Bryan A Laffitte; Sean B Joseph; Robert Walczak; Liming Pei; DAMIEN WILPITZ; Jon L Collins; Peter Tontonoz
Autoregulation of the human liver X receptor alpha promoter.
Molecular and cellular biology 2001;21(22):7558-68.
2001: Heidi R Kast; CM Nguyen; Christopher J Sinal; Stacey A Jones; Bryan A Laffitte; Karen Reue; F J Gonzalez; Timothy M Willson; Peter A Edwards
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.
Molecular endocrinology (Baltimore, Md.) 2001;15(10):1720-8.
2001: Bryan A Laffitte; Joyce J Repa; Sean B Joseph; DAMIEN WILPITZ; Heidi R Kast; David J Mangelsdorf; Peter Tontonoz
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):507-12.
2001: Ajay Chawla; William A Boisvert; C H Lee; Bryan A Laffitte; Y Barak; Sean B Joseph; Debbie Liao; L Nagy; Peter A Edwards; Linda K Curtiss; Ronald M Evans; Peter Tontonoz
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.
Molecular cell 2001;7(1):161-71.
2000: Hooman Allayee; Bryan A Laffitte; Aldons J Lusis
Biochemistry. An absorbing study of cholesterol.
Science (New York, N.Y.) 2000;290(5497):1709-11.
2000: A Venkateswaran; Bryan A Laffitte; Sean B Joseph; Puiying A Mak; DAMIEN WILPITZ; Peter A Edwards; Peter Tontonoz
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12097-102.
2000: Bryan A Laffitte; Heidi R Kast; CM Nguyen; Ann Marie Zavacki; David D Moore; Peter A Edwards
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.
The Journal of biological chemistry 2000;275(14):10638-47.