FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert Lafyatis

Research Profile

Disorders

Living Beings

Chemicals & Drugs

Anatomy

Physiology

Gene Expression Regulation

Procedures

Immunohistochemistry

Co-author Network

Publications

TOP 3
Stefania Lenna; Viktor Martyanov; Raffaella Scorza; Romy B Christmann; Harrison W Farber; Alessandra G Farina; Robert Lafyatis; Michael L Whitfield; Tammara A Wood; Maria Trojanowska
Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension.
Romy B Christmann; Alsya J Affandi; Andreea M Bujor; Allison Mathes; Banafsheh Nazari; Cristina Padilla; Giuseppina Stifano; Robert Lafyatis
Thymic Stromal Lymphopoietin Is Up-Regulated in the Skin of Patients With Systemic Sclerosis and Induces Profibrotic Genes and Intracellular Signaling That Overlap With Those Induced by Interleukin-13 and Transforming Growth Factor β.
Asish K Ghosh; Robert Lafyatis; Bayar Thimmapaya; Swati Bhattacharyya; Giuseppina Farina; Jun Wei; Jianxiu Yu; John Varga
p300 Is Elevated in Systemic Sclerosis and Its Expression Is Positively Regulated by TGF-β: Epigenetic Feed-Forward Amplification of Fibrosis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert Lafyatis (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Stefania Lenna; Viktor Martyanov; Raffaella Scorza; Romy B Christmann; Harrison W Farber; Alessandra G Farina; Robert Lafyatis; Michael L Whitfield; Tammara A Wood; Maria Trojanowska
Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension.
Arthritis and rheumatism 2013;65(5):1357-66.
2013: Romy B Christmann; Alsya J Affandi; Andreea M Bujor; Allison Mathes; Banafsheh Nazari; Cristina Padilla; Giuseppina Stifano; Robert Lafyatis
Thymic Stromal Lymphopoietin Is Up-Regulated in the Skin of Patients With Systemic Sclerosis and Induces Profibrotic Genes and Intracellular Signaling That Overlap With Those Induced by Interleukin-13 and Transforming Growth Factor β.
Arthritis and rheumatism 2013;65(5):1335-46.
2013: Asish K Ghosh; Robert Lafyatis; Bayar Thimmapaya; Swati Bhattacharyya; Giuseppina Farina; Jun Wei; Jianxiu Yu; John Varga
p300 Is Elevated in Systemic Sclerosis and Its Expression Is Positively Regulated by TGF-β: Epigenetic Feed-Forward Amplification of Fibrosis.
The Journal of investigative dermatology 2013;133(5):1302-10.
2013: Stefania Lenna; Fernando Rodriguez-Pascual; Raffaella Scorza; Izabela Chrobak; G Alessandra Farina; Robert Lafyatis; Santiago Lamas; Maria Trojanowska
HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.
PloS one 2013;8(2):e56123.
2013: Swati Bhattacharyya; G R Scott Budinger; Feng Fang; Carol Feghali-Bostwick; Gilbert Feng; Kathleen Kelley; Robert Lafyatis; Denisa S Melichian; Gökhan M Mutlu; Richard M Pope; Timothy Radstake; Yunyun Su; Zenshiro Tamaki; John Varga
Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
The American journal of pathology 2013;182(1):192-205.
2012: Andreea M Bujor; Romy B Christmann; Paul Haines; Monica Junie; Robert Lafyatis; Cristina Padilla; Percival D Sampaio-Barros; Maria Trojanowska
Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
International journal of molecular medicine 2012;30(6):1473-80.
2012: Glady Hazitha Samuel; Andreea M Bujor; Robert Lafyatis; Stefania Lenna; Maria Trojanowska
Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis.
Journal of dermatological science 2012;67(3):166-72.
2012: Paul Haines; Faye N Hant; Robert Lafyatis; Maria Trojanowska; Andreea M Bujor
Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.
Journal of cellular and molecular medicine 2012;16(9):2238-46.
2012: Robert Lafyatis
Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition.
Nature reviews. Rheumatology 2012;8(8):441-2.
2012: Sarah A Pendergrass; Ian P Francis; Robert Lafyatis; Raphael Lemaire; J Matthew Mahoney; Michael L Whitfield
Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies.
The Journal of investigative dermatology 2012;132(5):1363-73.
2012: Matthew B Greenblatt; Robert Lafyatis; Jennifer L Sargent; Kelly Tsang; Michael L Whitfield; Giuseppina Farina; Laurie H Glimcher; Antonios O Aliprantis
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.
The American journal of pathology 2012;180(3):1080-94.
2012: Michael Dimarzio; Giuseppina Farina; Robert Lafyatis
Modeling innate immunity in murine skin: utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease.
Methods in molecular biology (Clifton, N.J.) 2012;900():317-26.
2012: Robert Lafyatis; Alessandra Farina
New insights into the mechanisms of innate immune receptor signalling in fibrosis.
The open rheumatology journal 2012;6():72-9.
2011: Romy B Christmann; Everett Hayes; Sarah Pendergrass; Cristina Padilla; Giuseppina Farina; Alsya J Affandi; Michael L Whitfield; Harrison W Farber; Robert Lafyatis
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.
Arthritis and rheumatism 2011;63(6):1718-28.
2011: Jun Wei; Denisa Melichian; Kazuhiro Komura; Monique Hinchcliff; Anna P Lam; Robert Lafyatis; Cara J Gottardi; Ormond A MacDougald; John Varga
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
Arthritis and rheumatism 2011;63(6):1707-17.
2011: Andreea M Bujor; Yoshihide Asano; Paul Haines; Robert Lafyatis; Maria Trojanowska
The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts.
Arthritis and rheumatism 2011;63(6):1729-37.
2011: Allison L Mathes; Robert Lafyatis
Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury.
Muscle & nerve 2011;43(5):733-40.
2011: Giuseppina Farina; Michael York; Cindy Collins; Robert Lafyatis
dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts.
Annals of the rheumatic diseases 2011;70(3):544-50.
2010: Jasper C A Broen; Ingrid L M Wolvers-Tettero; Lenny Geurts-van Bon; Madelon C Vonk; Marieke Coenen; Robert Lafyatis; Timothy R D J Radstake; Anton W Langerak
Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis.
Annals of the rheumatic diseases 2010;69(12):2213-6.
2010: Giuseppina A Farina; Michael R York; Michael Di Marzio; Cindy A Collins; Stephan Meller; Bernhard Homey; Ian R Rifkin; Ann Marshak-Rothstein; Timothy R D J Radstake; Robert Lafyatis
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis.
The Journal of investigative dermatology 2010;130(11):2583-93.
2010: Aba Somers; Jyh-Chang Jean; Cesar A Sommer; Amel Omari; Christopher C Ford; Jason Adam Mills; Lei Ying; Andreia Gianotti Sommer; Jenny M Jean; Brenden W Smith; Robert Lafyatis; Marie-France Demierre; Daniel J Weiss; Deborah L French; Paul Gadue; George J Murphy; Gustavo Mostoslavsky; Darrell N Kotton
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.
Stem cells (Dayton, Ohio) 2010;28(10):1728-40.
2010: Harrison W Farber; Robert W Simms; Robert Lafyatis
Care of patients with scleroderma in the intensive care setting.
Journal of intensive care medicine 2010;25(5):247-58.
2010: L van Bon; Calin Popa; Richard Huijbens; M Vonk; M York; R Simms; R Hesselstrand; D M Wuttge; Robert Lafyatis; T R D J Radstake
Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis.
Annals of the rheumatic diseases 2010;69(8):1539-47.
2010: Raphael Lemaire; Giuseppina Farina; Julie Bayle; Michael Dimarzio; Sarah A Pendergrass; Ausra Milano; Bernard Perbal; Michael L Whitfield; Robert Lafyatis
Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome.
The Journal of investigative dermatology 2010;130(6):1514-23.
2010: G Farina; D Lafyatis; Raphael Lemaire; Robert Lafyatis
A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis.
Arthritis and rheumatism 2010;62(2):580-8.
2010: Robert W Simms; Robert Lafyatis
Rituximab: a potential therapeutic advance in scleroderma: what is the evidence?
Rheumatology (Oxford, England) 2010;49(2):201-2.
2010: Romy B Christmann; Robert Lafyatis
The cytokine language of monocytes and macrophages in systemic sclerosis.
Arthritis research & therapy 2010;12(5):146.
2010: Sarah A Pendergrass; Everett Hayes; Giuseppina Farina; Raphael Lemaire; Harrison W Farber; Michael L Whitfield; Robert Lafyatis
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.
PloS one 2010;5(8):e12106.
2009: Robert Lafyatis; Michael York
Innate immunity and inflammation in systemic sclerosis.
Current opinion in rheumatology 2009;21(6):617-22.
2009: G Farina; Raphael Lemaire; P Pancari; J Bayle; Russell L Widom; Robert Lafyatis
Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta.
Annals of the rheumatic diseases 2009;68(3):435-41.
2009: Robert Lafyatis; eugene kissin; Michael York; Giuseppina Farina; Kerry Viger; Marvin Fritzler; Peter A Merkel; Robert W Simms
B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis.
Arthritis and rheumatism 2009;60(2):578-83.
2009: Timothy R D J Radstake; Madelon C Vonk; Marieke Dekkers; Mascha M V A P Schijvenaars; William L Treppichio; Robert Lafyatis; Gabriela Riemekasten; Frank van den Hoogen; Marieke Coenen
The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients.
Human immunology 2009;70(2):130-3.
2009: Christophe Richez; Kei Yasuda; Amanda A Watkins; Shizuo Akira; Robert Lafyatis; Jean Maguire van Seventer; Ian R Rifkin
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):820-8.
2009: Timothy R D J Radstake; Lenny van Bon; Jasper Broen; Mark Wenink; Kim Santegoets; Yanhui Deng; Anila Hussaini; Robert Simms; William W Cruikshank; Robert Lafyatis
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.
PloS one 2009;4(6):e5981.
2009: Timothy R D J Radstake; Lenny van Bon; Jasper Broen; Anila Hussiani; Roger Hesselstrand; Dirk M Wuttge; Yanhui Deng; Robbert Simms; Erik Lubberts; Robert Lafyatis
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.
PloS one 2009;4(6):e5903.
2009: A W T van Lieshout; Madelon C Vonk; S J H Bredie; L B A Joosten; Mihai G Netea; P L C M van Riel; Robert Lafyatis; F H J van den Hoogen; T R D J Radstake
Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion.
Scandinavian journal of rheumatology 2009;38(4):282-90.
2008: Julie Bayle; Jennifer Fitch; Kimberly Jacobsen; Rajiv Kumar; Robert Lafyatis; Raphael Lemaire
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.
The Journal of investigative dermatology 2008;128(4):871-81.
2008: Jo N Fleming; Richard A Nash; D O McLeod; David F Fiorentino; Howard M Shulman; M Kari Connolly; Jerry A Molitor; Gretchen Henstorf; Robert Lafyatis; David K Pritchard; Lawrence D Adams; Daniel E Furst; Stephen M Schwartz
Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?
PloS one 2008;3(1):e1452.
2008: Gerald S Horan; Susan Wood; Victor Ona; Dan Jun Li; Matvey E Lukashev; Paul H Weinreb; Kenneth J Simon; Kyungmin Hahm; Normand E Allaire; Nicola J Rinaldi; Jaya Goyal; Carol A Feghali-Bostwick; Eric L Matteson; Carl O'Hara; Robert Lafyatis; Gerald S Davis; Xiaozhu Huang; Dean Sheppard; Shelia M Violette
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
American journal of respiratory and critical care medicine 2008;177(1):56-65.
2007: Robert Lafyatis; Carl O'Hara; Carol A Feghali-Bostwick; Eric Matteson
B cell infiltration in systemic sclerosis-associated interstitial lung disease.
Arthritis and rheumatism 2007;56(9):3167-8.
2007: Alyson J Mangini; Robert Lafyatis; Jean Maguire van Seventer
Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus.
Annals of the New York Academy of Sciences 2007;1108():11-23.
2007: Michael York; Taro Nagai; Alyson J Mangini; Raphael Lemaire; Jean Maguire van Seventer; Robert Lafyatis
A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.
Arthritis and rheumatism 2007;56(3):1010-20.
2007: Antonios O Aliprantis; Jingsong Wang; John W Fathman; Raphael Lemaire; David M Dorfman; Robert Lafyatis; Laurie H Glimcher
Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2827-30.
2007: Raphael Lemaire; Julie Bayle; Robert P Mecham; Robert Lafyatis
Microfibril-associated MAGP-2 stimulates elastic fiber assembly.
The Journal of biological chemistry 2007;282(1):800-8.
2007: Robert Lafyatis; Ann Marshak-Rothstein
Toll-like receptors and innate immune responses in systemic lupus erythematosus.
Arthritis research & therapy 2007;9(6):222.
2007: Thomas Krieg; David Abraham; Robert Lafyatis
Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions.
Arthritis research & therapy 2007;9 Suppl 2():S4.
2006: Robert Lafyatis
Targeting fibrosis in systemic sclerosis.
Endocrine, metabolic & immune disorders drug targets 2006;6(4):395-400.
2006: eugene kissin; Peter A Merkel; Robert Lafyatis
Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis.
Arthritis and rheumatism 2006;54(11):3655-60.
2006: Raphael Lemaire; Julie Bayle; Robert Lafyatis
Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis.
Current opinion in rheumatology 2006;18(6):582-7.
2006: Aruna K Behera; Ethan Hildebrand; Jon Szafranski; Han-Hwa Hung; Alan J Grodzinsky; Robert Lafyatis; Alisa E Koch; Robert Kalish; George Perides; Allen C Steere; Linden T Hu
Role of aggrecanase 1 in Lyme arthritis.
Arthritis and rheumatism 2006;54(10):3319-29.
2006: Robert Lafyatis; Michael York; Ann Marshak-Rothstein
Antimalarial agents: closing the gate on Toll-like receptors?
Arthritis and rheumatism 2006;54(10):3068-70.
2005: Raphael Lemaire; Joseph H Korn; J Michael Shipley; Robert Lafyatis
Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma.
Arthritis and rheumatism 2005;52(6):1812-23.
2005: Yingzi Wang; Junning Wang; Lei Gao; Robert Lafyatis; Stefan Stamm; Athena Andreadis
Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1.
The Journal of biological chemistry 2005;280(14):14230-9.
2004: Raphael Lemaire; Joseph H Korn; William P Schiemann; Robert Lafyatis
Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.
The Journal of investigative dermatology 2004;123(6):1063-9.
2004: Raphael Lemaire; Guiseppina Farina; eugene kissin; J Michael Shipley; Constantine Bona; Joseph H Korn; Robert Lafyatis
Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.
Arthritis and rheumatism 2004;50(3):915-26.
2004: Junning Wang; Qing-Sheng Gao; Yingzi Wang; Robert Lafyatis; Stefan Stamm; Athena Andreadis
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.
Journal of neurochemistry 2004;88(5):1078-90.
2003: Satoshi Jodo; John T Kung; Sheng Xiao; Derek V Chan; Seiichi Kobayashi; Masatoshi Tateno; Robert Lafyatis; Shyr-Te Ju
Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure.
The Journal of biological chemistry 2003;278(9):7553-7.
2002: eugene kissin; Raphael Lemaire; Joseph H Korn; Robert Lafyatis
Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation.
Arthritis and rheumatism 2002;46(11):3000-9.
2002: Meltem Cevik Arikan; John Memmott; Jennifer A Broderick; Robert Lafyatis; Gavin Screaton; Stefan Stamm; Athena Andreadis
Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3.
Brain research. Molecular brain research 2002;101(1-2):109-21.
2002: Raphael Lemaire; Jayendra Prasad; Tsuyoshi Kashima; Jennifer Gustafson; James L Manley; Robert Lafyatis
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins.
Genes & development 2002;16(5):594-607.
2000: Qing-Sheng Gao; John Memmott; Robert Lafyatis; Stefan Stamm; Gavin Screaton; Athena Andreadis
Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.
Journal of neurochemistry 2000;74(2):490-500.
1999: Raphael Lemaire; A Winne; M Sarkissian; Robert Lafyatis
SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation.
European journal of immunology 1999;29(3):823-37.
1999: M Sarkissian; Robert Lafyatis
Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1772-9.
1998: D Felson; Robert Lafyatis; Joseph H Korn
Rheumatology. Biological agents--is the promise realised?
Lancet 1998;352 Suppl 4():SIV25.
1998: M Sarkissian; Robert Lafyatis
Transforming growth factor-beta and platelet derived growth factor regulation of fibrillar fibronectin matrix formation by synovial fibroblasts.
The Journal of rheumatology 1998;25(4):613-22.
1997: Raphael Lemaire; René-Marc Flipo; H Migaud; C Fontaine; Guillemette Huet; E Dacquembronne; Robert Lafyatis
Alternative splicing of the 5' region of cathepsin B pre-messenger RNA in rheumatoid synovial tissue.
Arthritis and rheumatism 1997;40(8):1540-2.
1996: M Sarkissian; A Winne; Robert Lafyatis
The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS.
The Journal of biological chemistry 1996;271(49):31106-14.
1994: Raphael Lemaire; René-Marc Flipo; didier monte; T Dupressoir; Bernard Duquesnoy; Jean-Yves Cesbron; A Janin; André Capron; Robert Lafyatis
Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.
The Journal of rheumatology 1994;21(8):1409-19.
1994: Guillemette Huet; Farid Zerimech; M C Dieu; B Hemon; G Grard; Malika Balduyck; A Janin; Robert Lafyatis; Pierre Degand
The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
International journal of cancer. Journal international du cancer 1994;57(6):875-82.
1994: F Denhez; Robert Lafyatis
Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot.
The Journal of biological chemistry 1994;269(23):16170-9.
1993: A G Geiser; Klaus J Busam; Seong-Jin Kim; Robert Lafyatis; M A O'Reilly; R Webbink; Anita B Roberts; Michael B. Sporn
Regulation of the transforming growth factor-beta 1 and -beta 3 promoters by transcription factor Sp1.
Gene 1993;129(2):223-8.
1993: Guillemette Huet; René-Marc Flipo; C Colin; A Janin; B Hemon; M Collyn-d'Hooghe; Robert Lafyatis; Bernard Duquesnoy; Pierre Degand
Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1.
Arthritis and rheumatism 1993;36(6):772-80.
1992: Robert Lafyatis; René-Marc Flipo; Bernard Duquesnoy; André Capron
Antibodies in rheumatoid synovial fluids bind to a restricted series of protein antigens in rheumatoid synovial tissue.
Arthritis and rheumatism 1992;35(9):1016-27.
1991: Robert Lafyatis; F Denhez; T Williams; Michael B. Sporn; A Roberts
Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.
Nucleic acids research 1991;19(23):6419-25.
1991: Kathleen C Flanders; G Lüdecke; S Engels; D S Cissel; Anita B Roberts; P Kondaiah; Robert Lafyatis; Michael B. Sporn; Klaus Unsicker
Localization and actions of transforming growth factor-beta s in the embryonic nervous system.
Development (Cambridge, England) 1991;113(1):183-91.
1991: Robert Lafyatis; Robert J Lechleider; Anita B Roberts; Michael B. Sporn
Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
Molecular and cellular biology 1991;11(7):3795-803.
1991: Ronald L Wilder; J P Case; Leslie J Crofford; G K Kumkumian; Robert Lafyatis; Elaine F Remmers; H Sano; Esther M Sternberg; D E Yocum
Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats.
Journal of cellular biochemistry 1991;45(2):162-6.
1991: Haya Lorberboum-Galski; Robert Lafyatis; J P Case; D FitzGerald; Ronald L Wilder; Ira Pastan
Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion.
International journal of immunopharmacology 1991;13(2-3):305-15.
1991: Ronald L Wilder; Elaine F Remmers; H Sano; J P Case; Robert Lafyatis
The cytokine network in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 2():44-7.
1991: Anita B Roberts; Seong-Jin Kim; T Noma; A B Glick; Robert Lafyatis; Robert J Lechleider; S B Jakowlew; A Geiser; M A O'Reilly; David Danielpour
Multiple forms of TGF-beta: distinct promoters and differential expression.
Ciba Foundation symposium 1991;157():7-15; discussion 15-28.
1991: Klaus Unsicker; Kathleen C Flanders; D S Cissel; Robert Lafyatis; Michael B. Sporn
Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system.
Neuroscience 1991;44(3):613-25.
1991: Elaine F Remmers; H Sano; Robert Lafyatis; J P Case; G K Kumkumian; timothy hla; Thomas Maciag; Ronald L Wilder
Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1.
The Journal of rheumatology 1991;18(1):7-13.
1990: J P Case; Robert Lafyatis; G K Kumkumian; Elaine F Remmers; Ronald L Wilder
IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3755-61.
1990: Robert Lafyatis; Robert J Lechleider; Seong-Jin Kim; S Jakowlew; Anita B Roberts; Michael B. Sporn
Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.
The Journal of biological chemistry 1990;265(31):19128-36.
1990: Robert Lafyatis; Seong-Jin Kim; P Angel; Anita B Roberts; Michael B. Sporn; Michael Karin; Ronald L Wilder
Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site.
Molecular endocrinology (Baltimore, Md.) 1990;4(7):973-80.
1990: Seong-Jin Kim; P Angel; Robert Lafyatis; K Hattori; K Y Kim; Michael B. Sporn; Michael Karin; Anita B Roberts
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Molecular and cellular biology 1990;10(4):1492-7.
1990: Seong-Jin Kim; Robert Lafyatis; K Y Kim; P Angel; H Fujiki; Michael Karin; Michael B. Sporn; Anita B Roberts
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.
Cell regulation 1990;1(3):269-78.
1990: F Denhez; Robert Lafyatis; P Kondaiah; Anita B Roberts; Michael B. Sporn
Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3.
Growth factors (Chur, Switzerland) 1990;3(2):139-46.
1990: Elaine F Remmers; Robert Lafyatis; G K Kumkumian; J P Case; A B Roberts; Michael B. Sporn; Ronald L Wilder
Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis.
Growth factors (Chur, Switzerland) 1990;2(2-3):179-88.
1990: Ronald L Wilder; Robert Lafyatis; A B Roberts; J P Case; G K Kumkumian; H Sano; Michael B. Sporn; Elaine F Remmers
Transforming growth factor-beta in rheumatoid arthritis.
Annals of the New York Academy of Sciences 1990;593():197-207.
1989: J P Case; H Sano; Robert Lafyatis; Elaine F Remmers; G K Kumkumian; Ronald L Wilder
Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
The Journal of clinical investigation 1989;84(6):1731-40.
1989: J P Case; Robert Lafyatis; Elaine F Remmers; G K Kumkumian; Ronald L Wilder
Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.
The American journal of pathology 1989;135(6):1055-64.
1989: Ronald L Wilder; Robert Lafyatis; D E Yocum; J P Case; G K Kumkumian; Elaine F Remmers
Mechanisms of bone and cartilage destruction in rheumatoid arthritis: lessons from the streptococcal cell wall arthritis model in LEW/N rats.
Clinical and experimental rheumatology 1989;7 Suppl 3():S123-7.
1989: Robert Lafyatis; N L Thompson; Elaine F Remmers; K C Flanders; N S Roche; S J Kim; J P Case; Michael B. Sporn; A B Roberts; Ronald L Wilder
Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1142-8.
1989: G K Kumkumian; Robert Lafyatis; Elaine F Remmers; J P Case; S J Kim; Ronald L Wilder
Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):833-7.
1989: Robert Lafyatis; Elaine F Remmers; A B Roberts; D E Yocum; Michael B. Sporn; Ronald L Wilder
Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.
The Journal of clinical investigation 1989;83(4):1267-76.
1989: J P Case; Haya Lorberboum-Galski; Robert Lafyatis; D FitzGerald; Ronald L Wilder; Ira Pastan
Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):287-91.
1988: D E Yocum; Robert Lafyatis; Elaine F Remmers; H Ralph Schumacher; Ronald L Wilder
Hyperplastic synoviocytes from rats with streptococcal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable.
The American journal of pathology 1988;132(1):38-48.