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Reyes Laguna

Research Profile

Chemicals & Drugs

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Physiology

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Publications

TOP 3
Caroline Meyers; Matilde Yáñez; Abdelaziz Elmaatougi; Tom Verhelst; Alberto Coelho; Matilde Yañez; Guy Lemière; Xerardo García-Mera; Reyes Laguna; Ernesto Cano; Bert U W Maes; Eddy Sotelo
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
Alberto Coelho; Enrique Raviña; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Eddy Sotelo
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity.
Abel Crespo; Caroline Meyers; Alberto Coelho; Matilde Yáñez; Matilde Yañez; Eddy Sotelo; Bert U W Maes; Reyes Laguna; Ernesto Cano; Guy Lemière; Enrique Raviña
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.

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All Publications

2008: Caroline Meyers; Matilde Yáñez; Abdelaziz Elmaatougi; Tom Verhelst; Alberto Coelho; Matilde Yañez; Guy Lemière; Xerardo García-Mera; Reyes Laguna; Ernesto Cano; Bert U W Maes; Eddy Sotelo
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
Bioorganic & medicinal chemistry letters 2008;18(2):793-7.
2007: Alberto Coelho; Enrique Raviña; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Eddy Sotelo
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity.
Journal of medicinal chemistry 2007;50(26):6476-84.
2006: Abel Crespo; Caroline Meyers; Alberto Coelho; Matilde Yáñez; Matilde Yañez; Eddy Sotelo; Bert U W Maes; Reyes Laguna; Ernesto Cano; Guy Lemière; Enrique Raviña
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.
Bioorganic & medicinal chemistry letters 2006;16(4):1080-3.
2004: José Leiro; Ezequiel Alvarez; Juan A Arranz; Reyes Laguna; Eugenio Uriarte; Francisco Orallo
Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes.
Journal of leukocyte biology 2004;75(6):1156-65.
2004: Alberto Coelho; Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.
Bioorganic & medicinal chemistry letters 2004;14(2):321-4.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.
Chemical & pharmaceutical bulletin 2002;50(12):1574-7.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Vicente Terrades; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions.
Bioorganic & medicinal chemistry 2002;10(9):2873-82.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; José Brea; Enrique Raviña
Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(12):1575-7.
1999: A Montero-Lastres; Nuria Fraiz; Reyes Laguna; Ernesto Cano; I Estevez; Enrique Raviña
Pyridazines. XVIII. 6-Aryl-3(2H)-pyridazinones inhibit calcium influx in stimulated platelets.
Biological & pharmaceutical bulletin 1999;22(12):1376-9.
1999: Lourdes Santana; Marta Teijeira; Eugenio Uriarte; C Teran; B Liñares; R Villar; Reyes Laguna; Ernesto Cano
AM1 theoretical study, synthesis and biological evaluation of some benzofuran analogues of anti-inflammatory arylalkanoic acids.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;7(2):161-6.
1997: Reyes Laguna; B Rodriguez-Liñares; Ernesto Cano; I Estevez; Enrique Raviña; Eddy Sotelo
Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors.
Chemical & pharmaceutical bulletin 1997;45(7):1151-5.