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Josephine Lai

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Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Melinda A Mittelman-Smith; Hemalini Williams; Philippe Ciofi; Sally J Krajewski-Hall; Josephine Lai; Nathaniel T McMullen; Naomi E Rance
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.
Milena De Felice; G Dussor; Howard L Fields; Tamara King; Josephine Lai; Michael H Ossipov; Janice Oyarzo; Theodore Price; Raul Sanoja; Todd W Vanderah; Louis Vera-Portocarrero; Ruizhong Wang; Frank Porreca
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.

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All Publications

2013: Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorganic & medicinal chemistry letters 2013;23(11):3434-7.
2012: Melinda A Mittelman-Smith; Hemalini Williams; Philippe Ciofi; Sally J Krajewski-Hall; Josephine Lai; Nathaniel T McMullen; Naomi E Rance
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.
Endocrinology 2012;153(6):2800-12.
2011: Milena De Felice; G Dussor; Howard L Fields; Tamara King; Josephine Lai; Michael H Ossipov; Janice Oyarzo; Theodore Price; Raul Sanoja; Todd W Vanderah; Louis Vera-Portocarrero; Ruizhong Wang; Frank Porreca
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.
Pain 2011;152(12):2701-9.
2011: Ruben Vardanyan; Eva Varga; Peg Davis; Vlad K Kumirov; Josephine Lai; Erika Liktor-Busa; Gary S Nichol; Frank Porreca; David Rankin; Todd W Vanderah; Victor J Hruby
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Bioorganic & medicinal chemistry 2011;19(20):6135-42.
2011: Tamara King; Josephine Lai; Ramon Mercado; Alec Okun; Chaoling Qu; Jiyang Ren; Triza Brion; Frank Porreca
Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity.
Pain 2011;152(9):1997-2005.
2011: Chaoling Qu; Howard L Fields; Tamara King; Josephine Lai; Alec Okun; Frank Porreca
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
Pain 2011;152(7):1641-8.
2011: Katherine E Hanlon; Dave S Herman; Richard S Agnes; Tally M Largent-Milnes; Isuru R Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon-Sun Lee; Michael H Ossipov; Victor J Hruby; Josephine Lai; Frank Porreca; Todd W Vanderah
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.
Brain research 2011;1395():1-11.
2011: Louis P Vera-Portocarrero; Tamara King; Josephine Lai; Michael H Ossipov; Frank Porreca
Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats.
The journal of pain : official journal of the American Pain Society 2011;12(6):667-76.
2011: Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal of medicinal chemistry 2011;54(7):2029-38.
2011: Yeon Sun Lee; Shou-wu Ma; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Scott M Cowell; Peg Davis; Katherine E Hanlon; Vinod Kulkarani; Josephine Lai; Victor J Hruby
Development of potent μ and δ opioid agonists with high lipophilicity.
Journal of medicinal chemistry 2011;54(1):382-6.
2010: T M Largent-Milnes; T Yamamoto; P Nair; J W Moulton; V J Hruby; Josephine Lai; Frank Porreca; T W Vanderah
Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
British journal of pharmacology 2010;161(5):986-1001.
2010: Marina Vardanyan; Ohannes K Melemedjian; Theodore J Price; Michael H Ossipov; Josephine Lai; Ed Roberts; Terrence L Boos; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice; Frank Porreca
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist.
Pain 2010;151(2):257-65.
2010: Qingmin Chen; Louis P Vera-Portocarrero; Michael H Ossipov; Marina Vardanyan; Josephine Lai; Frank Porreca
Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.
Pancreas 2010;39(8):1220-5.
2010: Milena De Felice; Michael H Ossipov; Ruizhong Wang; G Dussor; Josephine Lai; Ian D Meng; Juliana Chichorro; John S Andrews; Suman Rakhit; Shawn Maddaford; David Dodick; Frank Porreca
Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.
Brain : a journal of neurology 2010;133(Pt 8):2475-88.
2010: Yeon Sun Lee; Steve Fernandes; Vinod Kulkarani; Alexander V Mayorov; Peg Davis; Shou-wu Ma; Kathy Brown; Robert J Gillies; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorganic & medicinal chemistry letters 2010;20(14):4080-4.
2010: Milena De Felice; Michael H Ossipov; Ruizhong Wang; Josephine Lai; Juliana Chichorro; Ian Meng; David W Dodick; Todd W Vanderah; G Dussor; Frank Porreca
Triptan-induced latent sensitization: a possible basis for medication overuse headache.
Annals of neurology 2010;67(3):325-37.
2009: Tamara King; Louis Vera-Portocarrero; Tannia Gutierrez; Todd W Vanderah; G Dussor; Josephine Lai; Howard Fields; Frank Porreca
Unmasking the tonic-aversive state in neuropathic pain.
Nature neuroscience 2009;12(11):1364-6.
2009: Takashi Yamamoto; Padma Nair; Shou-wu Ma; Peg Davis; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Josef Vagner; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2009;52(16):5164-75.
2009: Ruben Vardanyan; Gokhale Vijay; Gary S Nichol; Lu Liu; Isuru Kumarasinghe; Peg Davis; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorganic & medicinal chemistry 2009;17(14):5044-53.
2009: Wenjun Zhang; Shannon Gardell; Dongqin Zhang; Jennifer Y Xie; Richard S Agnes; Hamid Badghisi; Victor J Hruby; Naomi Rance; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.
Brain : a journal of neurology 2009;132(Pt 3):778-87.
2009: Anna Vardanyan; Ruizhong Wang; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; Tamara King
TRPV1 receptor in expression of opioid-induced hyperalgesia.
The journal of pain : official journal of the American Pain Society 2009;10(3):243-52.
2009: Rebecca Edelmayer; Todd W Vanderah; Lisa Majuta; En-Tan Zhang; Beatriz Fioravanti; Milena De Felice; Juliana G Chichorro; Michael H Ossipov; Tamara King; Josephine Lai; Shashi H Kori; Andrew C Nelsen; Keri E Cannon; Mary M Heinricher; Frank Porreca
Medullary pain facilitating neurons mediate allodynia in headache-related pain.
Annals of neurology 2009;65(2):184-93.
2009: Padma Nair; Takashi Yamamoto; Vinod Kulkarni; Sharif Moye; Edita Navratilova; Peg Davis; Tally Largent; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: YeonSun Lee; Ravil Petrov; Vinod Kulkarni; Byoung J Min; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd W Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2008: Miaw-Chyi Luo; Qingmin Chen; Michael H Ossipov; David R Rankin; Frank Porreca; Josephine Lai
Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia.
The journal of pain : official journal of the American Pain Society 2008;9(12):1096-105.
2008: Beatriz Fioravanti; Milena De Felice; Cheryl L Stucky; Karen A Medler; Miaw-Chyi Luo; Luis R Gardell; mukwaya Ibrahim; T Philip Malan; Henry I Yamamura; Michael H Ossipov; Tamara King; Josephine Lai; Frank Porreca; Todd W Vanderah
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11593-602.
2008: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Richard S Agnes; Jinfa Ying; Katalin E Kövér; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides 2008;29(8):1413-23.
2008: Josephine Lai; Miaw-chyi Luo; Qingmin Chen; Frank Porreca
Pronociceptive actions of dynorphin via bradykinin receptors.
Neuroscience letters 2008;437(3):175-9.
2008: Todd W Vanderah; Tally Largent-Milnes; Josephine Lai; Frank Porreca; Richard A Houghten; Frédérique Menzaghi; Kazimierz Wisniewski; Jacek Stalewski; Javier Sueiras-Diaz; Robert Galyean; Claudio D Schteingart; Jean-Louis Junien; Jerzy Trojnar; PJ Rivière
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
European journal of pharmacology 2008;583(1):62-72.
2008: Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Yeon Sun Lee; Richard S Agnes; James P Cain; Vinod Kulkarni; Minying Cai; Christine Salibay; Kathy Ciano; Ravil R Petrov; Alexander V Mayorov; Josef Vagner; Dev Trivedi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Biopolymers 2008;90(3):433-8.
2007: Yeon Sun Lee; Ravil R Petrov; chad park; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Journal of medicinal chemistry 2007;50(22):5528-32.
2007: Tamara King; Anna Vardanyan; Lisa Majuta; Ohannes Melemedjian; Raymond B Nagle; Anne E Cress; Todd W Vanderah; Josephine Lai; Frank Porreca
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer.
Pain 2007;132(1-2):154-68.
2007: Adriano Mollica; Giovanni Guardiani; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Luisa Mannina; Anatoli P Sobolev; Victor J Hruby
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Journal of medicinal chemistry 2007;50(13):3138-42.
2007: Takashi Yamamoto; Padma Nair; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Todd W Vanderah; Henry I Yamamura; Frank Porreca; Victor J Hruby
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: En-Tan Zhang; Michael H Ossipov; Dong-Qin Zhang; Josephine Lai; Frank Porreca
Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons.
Pain 2007;129(1-2):143-54.
2007: Louis P Vera-Portocarrero; En-Tan Zhang; Tamara King; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Pain 2007;129(1-2):35-45.
2007: Yeon Sun Lee; Joel Nyberg; Sharif Moye; Richard S Agnes; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(8):2161-5.
2007: Yeon Sun Lee; Richard S Agnes; Peg Davis; Shou-wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J Hruby
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Journal of medicinal chemistry 2007;50(1):165-8.
2006: Josephine Lai; Miaw-Chyi Luo; Qingmin Chen; Shouwu Ma; Luis R Gardell; Michael H Ossipov; Frank Porreca
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
Nature neuroscience 2006;9(12):1534-40.
2006: Louis P Vera-Portocarrero; En-Tan Zhang; Michael H Ossipov; Jennifer Y Xie; Tamara King; Josephine Lai; Frank Porreca
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.
Neuroscience 2006;140(4):1311-20.
2006: Richard S Agnes; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Journal of medicinal chemistry 2006;49(10):2868-75.
2006: Mohab M Ibrahim; Megan L Rude; Nicola J Stagg; Heriberto P Mata; Josephine Lai; Todd W Vanderah; Frank Porreca; Nancy E Buckley; Alexandros Makriyannis; T Philip Malan
CB2 cannabinoid receptor mediation of antinociception.
Pain 2006;122(1-2):36-42.
2006: Luis R Gardell; Tamara King; Michael H Ossipov; Kenner C Rice; Josephine Lai; Todd W Vanderah; Frank Porreca
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.
Neuroscience letters 2006;396(1):44-9.
2006: Yeon Sun Lee; Richard S Agnes; Hamid Badghisi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1773-80.
2006: Adriano Mollica; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and biological activity of the first cyclic biphalin analogues.
Bioorganic & medicinal chemistry letters 2006;16(2):367-72.
2006: Victor J Hruby; Frank Porreca; Henry I Yamamura; Gordon Tollin; Richard S Agnes; Yeon Sun Lee; Minying Cai; Isabel D Alves; Scott M Cowell; Eva Varga; Peg Davis; Zdzislaw Salamon; William R Roeske; Todd W Vanderah; Josephine Lai
New paradigms and tools in drug design for pain and addiction.
The AAPS journal 2006;8(3):E450-60.
2005: Ahmet Dogrul; Edward J Bilsky; Michael H Ossipov; Josephine Lai; Frank Porreca
Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance.
Anesthesia and analgesia 2005;101(6):1730-5.
2005: Tamara King; Luis R Gardell; Ruizhong Wang; Anna Vardanyan; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Stephen P Hunt; Victor J Hruby; Josephine Lai; Frank Porreca
Role of NK-1 neurotransmission in opioid-induced hyperalgesia.
Pain 2005;116(3):276-88.
2005: Adriano Mollica; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.
Bioorganic & medicinal chemistry letters 2005;15(10):2471-5.
2005: Mohab M Ibrahim; Frank Porreca; Josephine Lai; Phillip J Albrecht; Frank rice; Alla Khodorova; Gudarz Davar; Alexandros Makriyannis; Todd W Vanderah; Heriberto P Mata; T Philip Malan
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3093-8.
2005: Jennifer Y Xie; David Herman; Carl-Olav Stiller; Luis R Gardell; Michael H Ossipov; Josephine Lai; Frank Porreca; Todd W Vanderah
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):409-16.
2005: Tamara King; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?
Neuro-Signals 2005;14(4):194-205.
2005: Miaw-Chyi Luo; Dong-Qin Zhang; Shou-wu Ma; Yuan-Yuan Huang; Sam J Shuster; Frank Porreca; Josephine Lai
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Molecular pain 2005;1():29.
2005: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; Frank Porreca
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.
Biopolymers 2005;80(2-3):319-24.
2004: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; T Philip Malan; Victor J Hruby; Frank Porreca
Antinociceptive and nociceptive actions of opioids.
Journal of neurobiology 2004;61(1):126-48.
2004: Todd W Vanderah; Claudio D Schteingart; Jerzy Trojnar; Jean-Louis Junien; Josephine Lai; Pierre J-M Riviere
FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A peripheral efficacious kappa opioid agonist with unprecedented selectivity.
The Journal of pharmacology and experimental therapeutics 2004;310(1):326-33.
2004: Qingmin Chen; Tamara King; Todd W Vanderah; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics.
The journal of pain : official journal of the American Pain Society 2004;5(5):281-9.
2004: Aline Quartilho; Heriberto P Mata; Mohab M Ibrahim; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; T Philip Malan
Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists.
Anesthesiology 2004;100(6):1538-44.
2004: Josephine Lai; Frank Porreca; John C Hunter; Michael S Gold
Voltage-gated sodium channels and hyperalgesia.
Annual review of pharmacology and toxicology 2004;44():371-97.
2004: Luis R Gardell; mukwaya Ibrahim; Ruizhong Wang; Zaijie Jim Wang; Michael H Ossipov; T Philip Malan; Frank Porreca; Josephine Lai
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Neuroscience 2004;123(1):43-52.
2003: Luis R Gardell; Ruizhong Wang; Chris Ehrenfels; Michael H Ossipov; Anthony J Rossomando; Stephan Miller; Carolyn Buckley; Amber K Cai; Albert Tse; Susan F Foley; BangJian Gong; Lee Walus; Paul Carmillo; Dane Worley; Carol Huang; Thomas Engber; Blake Pepinsky; Richard L Cate; Todd W Vanderah; Josephine Lai; Dinah W Y Sah; Frank Porreca
Multiple actions of systemic artemin in experimental neuropathy.
Nature medicine 2003;9(11):1383-9.
2003: Luis R Gardell; Todd W Vanderah; S E Gardell; Ruizhong Wang; Michael H Ossipov; Josephine Lai; Frank Porreca
Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8370-9.
2003: Mohab M Ibrahim; Hongfeng Deng; Alexander Zvonok; Debra A Cockayne; Joyce Kwan; Heriberto P Mata; Todd W Vanderah; Josephine Lai; Frank Porreca; Alexandros Makriyannis; T Philip Malan
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10529-33.
2003: Michael H Ossipov; Josephine Lai; Todd W Vanderah; Frank Porreca
Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance.
Life sciences 2003;73(6):783-800.
2003: Victor J Hruby; Richard S Agnes; Peg Davis; Shou-wu Ma; Yeon Sun Lee; Todd W Vanderah; Josephine Lai; Frank Porreca
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.
2003: Josephine Lai; John C Hunter; Frank Porreca
The role of voltage-gated sodium channels in neuropathic pain.
Current opinion in neurobiology 2003;13(3):291-7.
2003: T Philip Malan; Mohab M Ibrahim; Josephine Lai; Todd W Vanderah; Alexandros Makriyannis; Frank Porreca
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?
Current opinion in pharmacology 2003;3(1):62-7.
2003: Ruizhong Wang; W Guo; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain.
Neuroscience 2003;121(3):815-24.
2002: Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Dynorphin-independent spinal cannabinoid antinociception.
Pain 2002;100(3):243-8.
2002: Michael H Ossipov; En-Tan Zhang; Cristina Carvajal; Luis R Gardell; Rémi Quirion; Yvan Dumont; Josephine Lai; Frank Porreca
Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(22):9858-67.
2002: Luis R Gardell; Ruizhong Wang; Shannon E Burgess; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Josephine Lai; Frank Porreca
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6747-55.
2002: Luis R Gardell; Shannon E Burgess; Ahmet Dogrul; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance.
Pain 2002;98(1-2):79-88.
2002: Shannon E Burgess; Luis R Gardell; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Josephine Lai; Frank Porreca
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):5129-36.
2002: Josephine Lai; Michael S Gold; Chang Sook Kim; Di Bian; Michael H Ossipov; John C Hunter; Frank Porreca
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.
Pain 2002;95(1-2):143-52.
2001: Josephine Lai; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Frank Porreca
Neuropathic pain: the paradox of dynorphin.
Molecular interventions 2001;1(3):160-7.
2001: Mohab M Ibrahim; Heriberto P Mata; M Chawla; Josephine Lai; Frank Porreca; T Philip Malan
Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: lack of correlation with dynorphin content.
The journal of pain : official journal of the American Pain Society 2001;2(4):241-9.
2001: Frank Porreca; Shannon E Burgess; Luis R Gardell; Todd W Vanderah; T Philip Malan; Michael H Ossipov; D A Lappi; Josephine Lai
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5281-8.
2001: Todd W Vanderah; Michael H Ossipov; Josephine Lai; T Philip Malan; Frank Porreca
Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin.
Pain 2001;92(1-2):5-9.
2001: Zaijie Jim Wang; Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Miles B Brennan; Ute Hochgeschwender; Victor J Hruby; T Philip Malan; Josephine Lai; Frank Porreca
Pronociceptive actions of dynorphin maintain chronic neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1779-86.
2001: H Sun; K Ren; C M Zhong; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections.
Pain 2001;90(1-2):105-11.
2001: Todd W Vanderah; N M Suenaga; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):279-86.
2000: Todd W Vanderah; Luis R Gardell; Shannon E Burgess; mukwaya Ibrahim; Ahmet Dogrul; C M Zhong; En-Tan Zhang; T Philip Malan; Michael H Ossipov; Josephine Lai; Frank Porreca
Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):7074-9.
2000: CJ Kovelowski; Michael H Ossipov; H Sun; Josephine Lai; T Philip Malan; Frank Porreca
Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat.
Pain 2000;87(3):265-73.
2000: Michael H Ossipov; T Hong Sun; P Malan; Josephine Lai; Frank Porreca
Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats.
Neuroscience letters 2000;290(2):129-32.
2000: Q Tang; Ronald M Lynch; Frank Porreca; Josephine Lai
Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism.
Journal of neurophysiology 2000;83(5):2610-5.
2000: T Philip Malan; Michael H Ossipov; Luis R Gardell; mukwaya Ibrahim; Di Bian; Josephine Lai; Frank Porreca
Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats.
Pain 2000;86(1-2):185-94.
2000: Yoshiaki Hosohata; Todd W Vanderah; TH Burkey; Michael H Ossipov; CJ Kovelowski; I Sora; George R. Uhl; X Zhang; Kenner C Rice; William R Roeske; Victor J Hruby; Henry I Yamamura; Josephine Lai; Frank Porreca
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
2000: Michael H Ossipov; Josephine Lai; T Philip Malan; Frank Porreca
Spinal and supraspinal mechanisms of neuropathic pain.
Annals of the New York Academy of Sciences 2000;909():12-24.
2000: Josephine Lai; John C Hunter; Michael H Ossipov; Frank Porreca
Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons.
Methods in enzymology 2000;314():201-13.
1999: Q Tang; R Gandhoke; A Burritt; Victor J Hruby; Frank Porreca; Josephine Lai
High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors.
The Journal of pharmacology and experimental therapeutics 1999;291(2):760-5.
1999: CJ Kovelowski; Di Bian; Victor J Hruby; Josephine Lai; Michael H Ossipov; Frank Porreca
Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat.
Brain research 1999;843(1-2):12-7.
1999: Frank Porreca; Josephine Lai; Di Bian; S Wegert; Michael H Ossipov; R M Eglen; LC Kassotakis; SD Novakovic; Douglas Rabert; L Sangameswaran; John C Hunter
A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7640-4.
1999: Di Bian; Michael H Ossipov; mukwaya Ibrahim; Robert Raffa; Ronald J Tallarida; T Philip Malan; Josephine Lai; Frank Porreca
Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum.
Brain research 1999;831(1-2):55-63.
1999: Michael H Ossipov; Di Bian; T Philip Malan; Josephine Lai; Frank Porreca
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
Pain 1999;79(2-3):127-33.
1998: Frank Porreca; Q B Tang; Di Bian; Maureen S Riedl; Robert Elde; Josephine Lai
Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury.
Brain research 1998;795(1-2):197-203.
1997: Paul S. St. John; C P Ludwig; Josephine Lai
Substance P receptor expression and cellular responses to substance P in prenatal rat spinal cord cells.
Journal of receptor and signal transduction research 1997;17(4):569-83.
1997: Josephine Lai; T J Crook; A Payne; Ronald M Lynch; Frank Porreca
Antisense targeting of delta opioid receptors in NG 108-15 cells: direct correlation between oligodeoxynucleotide uptake and receptor density.
The Journal of pharmacology and experimental therapeutics 1997;281(1):589-96.
1996: E J Bilsky; T Wang; Josephine Lai; F Porreca
Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide.
Neuroscience letters 1996;220(3):155-8.
1996: Josephine Lai; S W Ma; F Porreca; Robert Raffa
Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells.
European journal of pharmacology 1996;316(2-3):369-72.
1996: Josephine Lai; Maureen S Riedl; Laura S Stone; Ulf Arvidsson; E J Bilsky; George L Wilcox; Robert Elde; F Porreca
Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo.
Neuroscience letters 1996;213(3):205-8.
1996: Michael H Ossipov; CJ Kovelowski; H Wheeler-Aceto; Alan Cowan; John C Hunter; Josephine Lai; T Philip Malan; F Porreca
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
The Journal of pharmacology and experimental therapeutics 1996;277(2):784-8.
1996: E J Bilsky; R N Bernstein; Victor J Hruby; Richard B Rothman; Josephine Lai; F Porreca
Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo.
The Journal of pharmacology and experimental therapeutics 1996;277(1):491-501.
1996: P A Zaki; E J Bilsky; Todd W Vanderah; Josephine Lai; Christopher J Evans; F Porreca
Opioid receptor types and subtypes: the delta receptor as a model.
Annual review of pharmacology and toxicology 1996;36():379-401.
1995: ML Nichols; Di Bian; Michael H Ossipov; Josephine Lai; F Porreca
Regulation of morphine antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1339-45.
1995: Di Bian; ML Nichols; Michael H Ossipov; Josephine Lai; F Porreca
Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats.
Neuroreport 1995;6(15):1981-4.
1995: KP Mayfield; R Horvath; Josephine Lai; F Porreca
Increased expression of opioid delta receptors by deoxy conformation heme proteins in NG108-15 cells.
Brain research 1995;676(2):358-62.
1995: Paula Witt-Enderby; Henry I Yamamura; Marilyn Halonen; Josephine Lai; J D Palmer; John W Bloom
Regulation of airway muscarinic cholinergic receptor subtypes by chronic anticholinergic treatment.
Molecular pharmacology 1995;47(3):485-90.
1995: Josephine Lai; E J Bilsky; F Porreca
Treatment with antisense oligodeoxynucleotide to a conserved sequence of opioid receptors inhibits antinociceptive effects of delta subtype selective ligands.
Journal of receptor and signal transduction research 1995;15(1-4):643-50.
1994: Todd W Vanderah; Josephine Lai; Henry I Yamamura; F Porreca
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
Neuroreport 1994;5(18):2601-5.
1994: Josephine Lai; S W Ma; R H Zhu; Richard B Rothman; K U Lentes; F Porreca
Pharmacological characterization of the cloned kappa opioid receptor as a kappa 1b subtype.
Neuroreport 1994;5(16):2161-4.
1994: Josephine Lai; E J Bilsky; Richard B Rothman; F Porreca
Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta 2-agonist antinociception.
Neuroreport 1994;5(9):1049-52.
1994: E J Bilsky; R N Bernstein; Gavril W Pasternak; Victor J Hruby; D Patel; F Porreca; Josephine Lai
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor.
Life sciences 1994;55(2):PL37-43.
1992: Josephine Lai; Linda M Nunan; Sue Waite; S W Ma; John W Bloom; William R Roeske; Henry I Yamamura
Chimeric M1/M2 muscarinic receptors: correlation of ligand selectivity and functional coupling with structural modifications.
The Journal of pharmacology and experimental therapeutics 1992;262(1):173-80.
1992: H B Wei; William R Roeske; Josephine Lai; F Wanibuchi; K Hidaka; S Usuda; Henry I Yamamura
Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene.
Life sciences 1992;50(5):355-63.
1991: Josephine Lai; Sue Waite; John W Bloom; Henry I Yamamura; William R Roeske
The m2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins.
The Journal of pharmacology and experimental therapeutics 1991;258(3):938-44.
1991: Lin Mei; Josephine Lai; Henry I Yamamura; William R Roeske
Pharmacologic comparison of selected agonists for the M1 muscarinic receptor in transfected murine fibroblast cells (B82).
The Journal of pharmacology and experimental therapeutics 1991;256(2):689-94.
1991: Josephine Lai; T L Smith; Lin Mei; M Ikeda; Y Fujiwara; J Gomez; M Halonen; William R Roeske; Henry I Yamamura
The molecular properties of the M1 muscarinic receptor and its regulation of cytosolic calcium in a eukaryotic gene expression system.
Advances in experimental medicine and biology 1991;287():313-30.
1990: Josephine Lai; John W Bloom; Henry I Yamamura; William R Roeske
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Life sciences 1990;47(12):1001-13.
1989: Lin Mei; Josephine Lai; Henry I Yamamura; William R Roeske
The relationship between agonist states of the M1 muscarinic receptor and the hydrolysis of inositol lipids in transfected murine fibroblast cells (B82) expressing different receptor densities.
The Journal of pharmacology and experimental therapeutics 1989;251(1):90-7.
1989: Lin Mei; Josephine Lai; William R Roeske; Claire M Fraser-Liggett; J C Venter; Henry I Yamamura
Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.
The Journal of pharmacology and experimental therapeutics 1989;248(2):661-70.
1988: Josephine Lai; Lin Mei; W R Roeske; F Z Chung; Henry I Yamamura; J Craig Venter
The cloned murine M1 muscarinic receptor is associated with the hydrolysis of phosphatidylinositols in transfected murine B82 cells.
Life sciences 1988;42(24):2489-502.
1988: J Craig Venter; U di Porzio; D A Robinson; S M Shreeve; Josephine Lai; A R Kerlavage; S P Fracek; K U Lentes; Claire M Fraser-Liggett
Evolution of neurotransmitter receptor systems.
Progress in neurobiology 1988;30(2-3):105-69.
1987: J Gocayne; D A Robinson; M G FitzGerald; F Z Chung; A R Kerlavage; K U Lentes; Josephine Lai; C D Wang; Claire M Fraser-Liggett; J Craig Venter
Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8296-300.