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Marikki Laiho

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Henna M Moore; Karita Peltonen; Baoyan Bai; Laureen Colis; Olli Matilainen; Marikki Laiho
Proteasome activity influences UV-mediated subnuclear localization changes of NPM.
Lei Zhu; Taija M Af Hällström; Sari Jäämaa; Marikki Laiho; Stig Nordling; Anna Sankila; Ulf-Håkan Stenman; Hannu Koistinen
PSA forms complexes with α1-antichymotrypsin in prostate.
Baoyan Bai; Marikki Laiho
Efficient sequential recovery of nucleolar macromolecular components.

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All Publications

2013: Henna M Moore; Karita Peltonen; Baoyan Bai; Laureen Colis; Olli Matilainen; Marikki Laiho
Proteasome activity influences UV-mediated subnuclear localization changes of NPM.
PloS one 2013;8(3):e59096.
2013: Lei Zhu; Taija M Af Hällström; Sari Jäämaa; Marikki Laiho; Stig Nordling; Anna Sankila; Ulf-Håkan Stenman; Hannu Koistinen
PSA forms complexes with α1-antichymotrypsin in prostate.
The Prostate 2013;73(2):219-26.
2012: Baoyan Bai; Marikki Laiho
Efficient sequential recovery of nucleolar macromolecular components.
Proteomics 2012;12(19-20):3044-8.
2012: Sari Jäämaa; Marikki Laiho
Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst.
Molecular oncology 2012;6(5):473-83.
2012: Sari Jäämaa; Päivi M Järvinen; Taija M Af Hällström; Leif C Andersson; Karita Peltonen; Ville Rantanen; Mirja Ruutu; Anna Sankila; Kimmo Taari; Marikki Laiho
Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate.
The Prostate 2012;72(10):1060-70.
2012: Päivi M Järvinen; Katri Koli; Arja M Band; Leena Latonen; Outi Leppäranta; Hester Liu; Henna M Moore; Marjukka Myllärniemi; Kaisa Salmenkivi; Marikki Laiho
Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.
Journal of cellular physiology 2012;227(6):2605-12.
2012: Arja M Band; Marikki Laiho
SnoN oncoprotein enhances estrogen receptor-α transcriptional activity.
Cellular signalling 2012;24(4):922-30.
2012: Päivi M Järvinen; Marikki Laiho
LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation.
Cellular signalling 2012;24(4):819-25.
2011: Zhewei Zhang; Hester Liu; Laxmi G Pellakuru; Zhiming Yang; Taija M af Hällström; Angelo M DeMarzo; Tsuyoshi Iwata; Sari Jäämaa; Marikki Laiho
Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture.
Cell cycle (Georgetown, Tex.) 2011;10(20):3545-53.
2011: Henna M Moore; Rainer Pepperkok; Ville Rantanen; Jeremy C Simpson; Baoyan Bai; François-Michel Boisvert; Angus I Lamond; Leena Latonen; Marikki Laiho
Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.
Molecular & cellular proteomics : MCP 2011;10(10):M111.009241.
2011: Xiaohua Ni; YONGGANG ZHANG; Judit Ribas; Wasim H Chowdhury; Mark Castanares; Zhewei Zhang; Marikki Laiho; Theodore L DeWeese; Shawn E Lupold
Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts.
The Journal of clinical investigation 2011;121(6):2383-90.
2011: Arja M Band; Marikki Laiho
Crosstalk of TGF-β and estrogen receptor signaling in breast cancer.
Journal of mammary gland biology and neoplasia 2011;16(2):109-15.
2011: Leena Latonen; H M Moore; B Bai; Sari Jäämaa; Marikki Laiho
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Oncogene 2011;30(7):790-805.
2010: Sari Jäämaa; Taija M Af Hällström; Anna Sankila; Ville Rantanen; Hannu Koistinen; Ulf-Håkan Stenman; Zhewei Zhang; Zhiming Yang; Angelo M DeMarzo; Kimmo Taari; Mirja Ruutu; Leif C Andersson; Marikki Laiho
DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue.
Cancer research 2010;70(21):8630-41.
2010: Leena Latonen; Päivi M Järvinen; Sari Suomela; Henna M Moore; Ulpu Saarialho-Kere; Marikki Laiho
Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.
Photodermatology, photoimmunology & photomedicine 2010;26(2):70-7.
2010: Mia A Björklund; Kari Vaahtomeri; Karita Peltonen; Benoît Viollet; Tomi Mäkelä; Arja M Band; Marikki Laiho
Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways.
Experimental cell research 2010;316(5):762-74.
2010: Grzegorz Sarek; Annika Järviluoma; Henna M Moore; Sari Tojkander; Salla Vartia; Peter Biberfeld; Marikki Laiho; Päivi M Ojala
Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.
PLoS pathogens 2010;6(3):e1000818.
2010: Marilin Sulg; Anna Kirjavainen; Katri Pajusola; Hansruedi Bueler; Jukka Ylikoski; Marikki Laiho; Ulla Pirvola
Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.
Journal of neurochemistry 2010;112(6):1513-26.
2010: Karita Peltonen; Laureen Colis; Hester Liu; Sari Jäämaa; Henna M Moore; Juulia Enbäck; Pirjo Laakkonen; Anne Vaahtokari; Richard J Jones; Taija M af Hällström; Marikki Laiho
Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
PloS one 2010;5(9):e12996.
2009: Arja M Band; Mia Björklund; Marikki Laiho
The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.
The Journal of biological chemistry 2009;284(51):35441-9.
2008: Taija M Kiviharju-Af Hällström; Marikki Laiho
Genetic changes and DNA damage responses in the prostate.
The Prostate 2008;68(8):902-18.
2008: Leena Latonen; Päivi M Järvinen; Marikki Laiho
Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death.
Experimental cell research 2008;314(4):738-47.
2007: Sonja Koopal; Johanna H Furuhjelm; Annika Järviluoma; Sari Jäämaa; Pawan Pyakurel; Christel Pussinen; Maria Wirzenius; Peter Biberfeld; Kari Alitalo; Marikki Laiho; Päivi M Ojala
Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
PLoS pathogens 2007;3(9):1348-60.
2007: Taija M Kiviharju-af Hällström; Sari Jäämaa; Mia Mönkkönen; Karita Peltonen; Leif C Andersson; René H Medema; Donna M Peehl; Marikki Laiho
Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7211-6.
2007: Grzegorz Sarek; Sari Kurki; Juulia Enbäck; Guergana Iotzova; Juergen Haas; Pirjo Laakkonen; Marikki Laiho; Päivi M Ojala
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.
The Journal of clinical investigation 2007;117(4):1019-28.
2007: Heidi Laine; Angelika Doetzlhofer; Johanna Mantela; Jukka Ylikoski; Marikki Laiho; Martine F Roussel; Neil Segil; Ulla Pirvola
p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(6):1434-44.
2007: Marikki Laiho; Eero Saksela
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(13):1535-6.
2005: Leena Latonen; Marikki Laiho
Cellular UV damage responses--functions of tumor suppressor p53.
Biochimica et biophysica acta 2005;1755(2):71-89.
2005: Karita Peltonen; Taija M Kiviharju; Päivi M Järvinen; Runar Ra; Marikki Laiho
Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2005;18(3):196-202.
2005: Maria von Willebrand; Klaus Köhler; Tuomo Alanko; Marikki Laiho; Olli Saksela
FGF-2 blocks TGF-beta1-mediated suppression of Bcl-2 in normal melanocytes.
Experimental dermatology 2005;14(3):202-8.
2005: Jose P Vaqué; Joaquin Navascues; Yuzuru Shiio; Marikki Laiho; Nuria Ajenjo; Itsaso Mauleon; David Matallanas; Piero Crespo; Javier León
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.
The Journal of biological chemistry 2005;280(2):1112-22.
2004: Sari Kurki; Karita Peltonen; Marikki Laiho
Nucleophosmin, HDM2 and p53: players in UV damage incited nucleolar stress response.
Cell cycle (Georgetown, Tex.) 2004;3(8):976-9.
2004: Sari Kurki; Karita Peltonen; Leena Latonen; Taija M Kiviharju; Päivi M Ojala; David Meek; Marikki Laiho
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
Cancer cell 2004;5(5):465-75.
2004: Leena Latonen; Marikki Laiho
[Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway].
Duodecim; lääketieteellinen aikakauskirja 2004;120(24):2868-71.
2003: Fan Zhang; Marikki Laiho
On and off: proteasome and TGF-beta signaling.
Experimental cell research 2003;291(2):275-81.
2003: Sari Kurki; Leena Latonen; Marikki Laiho
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
Journal of cell science 2003;116(Pt 19):3917-25.
2003: Fan Zhang; Mikael Lundin; Ari Ristimäki; Päivi Heikkilä; Johan Lundin; Jorma Isola; Heikki Joensuu; Marikki Laiho
Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas.
Cancer research 2003;63(16):5005-10.
2003: Massimiliano Gentile; Leena Latonen; Marikki Laiho
Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses.
Nucleic acids research 2003;31(16):4779-90.
2003: Marikki Laiho; Leena Latonen
Cell cycle control, DNA damage checkpoints and cancer.
Annals of medicine 2003;35(6):391-7.
2003: Leena Latonen; Sari Kurki; Kimmo Pitkänen; Marikki Laiho
p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction.
Cellular signalling 2003;15(1):95-102.
2002: Fan Zhang; Mia Mönkkönen; Stina Roth; Marikki Laiho
TGF-beta induced G(1) cell cycle arrest requires the activity of the proteasome pathway. Transforming growth factor.
Experimental cell research 2002;281(2):190-6.
2002: Fan Zhang; Mia Mönkkönen; Stina Roth; Marikki Laiho
Proteasomal activity modulates TGF-ss signaling in a gene-specific manner.
FEBS letters 2002;527(1-3):58-62.
2002: Jiri Buzek; Leena Latonen; Sari Kurki; Karita Peltonen; Marikki Laiho
Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277.
Nucleic acids research 2002;30(11):2340-8.
2002: Marikki Laiho
[Understanding carcinogenesis].
Duodecim; lääketieteellinen aikakauskirja 2002;118(17):1751-8.
2001: Leena Latonen; Y Taya; Marikki Laiho
UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.
Oncogene 2001;20(46):6784-93.
2001: Fan Zhang; Mikko Taipale; A Heiskanen; Marikki Laiho
Ectopic expression of Cdk6 circumvents transforming growth factor-beta mediated growth inhibition.
Oncogene 2001;20(41):5888-96.
2000: Mikko Taipale; E Tiihonen; A Heiskanen; Marikki Laiho
Accumulation of a form of p27(Kip1) not associated with Cdk-cyclin complexes in transforming growth factor-beta-arrested Mv1Lu cells.
Experimental cell research 2000;259(1):107-16.
1999: L Kivinen; M Tsubari; T Haapajärvi; M B Datto; X F Wang; Marikki Laiho
Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
Oncogene 1999;18(46):6252-61.
1999: L Kivinen; Marikki Laiho
Ras- and mitogen-activated protein kinase kinase-dependent and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2, platelet-derived growth factor, and transforming growth factor-beta1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(9):621-8.
1999: M Tsubari; Jussi Taipale; E Tiihonen; Jorma Keski-Oja; Marikki Laiho
Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity.
Molecular and cellular biology 1999;19(5):3654-63.
1999: T Haapajärvi; L Kivinen; A Heiskanen; C des Bordes; M B Datto; X F Wang; Marikki Laiho
UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.
Experimental cell research 1999;248(1):272-9.
1999: T Haapajärvi; Kimmo Pitkänen; Marikki Laiho
Human melanoma cell line UV responses show independency of p53 function.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(3):163-71.
1998: Kimmo Pitkänen; T Haapajärvi; Marikki Laiho
U.V.C.-induction of p53 activation and accumulation is dependent on cell cycle and pathways involving protein synthesis and phosphorylation.
Oncogene 1998;16(4):459-69.
1997: M Tsubari; E Tiihonen; Marikki Laiho
Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor.
Cancer research 1997;57(14):2966-73.
1997: T Haapajärvi; Kimmo Pitkänen; M Tsubari; Marikki Laiho
p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle.
Molecular and cellular biology 1997;17(6):3074-80.
1997: Berndt Enholm; Kristian J Paavonen; Ari Ristimäki; V Kumar; Y Gunji; Juha Klefstrom; L Kivinen; Marikki Laiho; B Olofsson; V Joukov; Ulf Eriksson; Kari Alitalo
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia.
Oncogene 1997;14(20):2475-83.
1996: L Kivinen; E Tiihonen; T Haapajärvi; Marikki Laiho
p21ras-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanisms.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1705-12.
1995: T Haapajärvi; L Kivinen; Kimmo Pitkänen; Marikki Laiho
Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation.
Oncogene 1995;11(1):151-9.
1993: L Kivinen; Kimmo Pitkänen; Marikki Laiho
Human retinoblastoma gene product prevents c-Ha-ras oncogene mediated cellular transformation of mouse fibroblasts.
Oncogene 1993;8(10):2703-11.
1993: Kimmo Pitkänen; L Kivinen; James A DeCaprio; Marikki Laiho
Expression of the human retinoblastoma gene product in mouse fibroblasts: effects on cell proliferation and susceptibility to transformation.
Experimental cell research 1993;207(1):99-106.
1992: Jeffrey L Wrana; Liliana Attisano; J Cárcamo; A Zentella; J Doody; Marikki Laiho; X F Wang; Joan Massagué
TGF beta signals through a heteromeric protein kinase receptor complex.
Cell 1992;71(6):1003-14.
1992: Joan Massagué; S Cheifetz; Marikki Laiho; D A Ralph; F M Weis; A Zentella
Transforming growth factor-beta.
Cancer surveys 1992;12():81-103.
1992: Marikki Laiho; Jorma Keski-Oja
Transforming growth factors-beta as regulators of cellular growth and phenotype.
Critical reviews in oncogenesis 1992;3(1-2):1-26.
1991: A Zentella; F M Weis; D A Ralph; Marikki Laiho; Joan Massagué
Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.
Molecular and cellular biology 1991;11(10):4952-8.
1991: Jorma Keski-Oja; K Koli; Jouko Lohi; Marikki Laiho
Growth factors in the regulation of plasminogen-plasmin system in tumor cells.
Seminars in thrombosis and hemostasis 1991;17(3):231-9.
1991: Marikki Laiho; F M Weis; F T Boyd; R A Ignotz; Joan Massagué
Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.
The Journal of biological chemistry 1991;266(14):9108-12.
1991: Marikki Laiho; L Rönnstrand; J Heino; James A DeCaprio; J W Ludlow; David M Livingston; Joan Massagué
Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.
Molecular and cellular biology 1991;11(2):972-8.
1990: S Cheifetz; H Hernandez; Marikki Laiho; Peter ten Dijke; K K Iwata; Joan Massagué
Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.
The Journal of biological chemistry 1990;265(33):20533-8.
1990: Marikki Laiho; M B Weis; Joan Massagué
Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.
The Journal of biological chemistry 1990;265(30):18518-24.
1990: Marikki Laiho; James A DeCaprio; J W Ludlow; David M Livingston; Joan Massagué
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation.
Cell 1990;62(1):175-85.
1990: F T Boyd; S Cheifetz; J Andres; Marikki Laiho; Joan Massagué
Transforming growth factor-beta receptors and binding proteoglycans.
Journal of cell science. Supplement 1990;13():131-8.
1990: Olli Saksela; Marikki Laiho
[Growth factors and the extracellular matrix].
Duodecim; lääketieteellinen aikakauskirja 1990;106(3):297-306.
1989: Marikki Laiho; Jorma Keski-Oja
Growth factors in the regulation of pericellular proteolysis: a review.
Cancer research 1989;49(10):2533-53.
1988: Marikki Laiho
Modulation of extracellular proteolytic activity and anchorage-independent growth of cultured cells by sarcoma cell-derived factors: relationships to transforming growth factor-beta.
Experimental cell research 1988;176(2):297-308.
1987: Marikki Laiho; Olli Saksela; Jorma Keski-Oja
Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.
The Journal of biological chemistry 1987;262(36):17467-74.
1987: L R Lund; A Riccio; P A Andreasen; L S Nielsen; P Kristensen; Marikki Laiho; Olli Saksela; F Blasi; K Danø
Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.
The EMBO journal 1987;6(5):1281-6.
1986: Marikki Laiho; Olli Saksela; P A Andreasen; Jorma Keski-Oja
Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.
The Journal of cell biology 1986;103(6 Pt 1):2403-10.
1986: Marikki Laiho; Olli Saksela; Jorma Keski-Oja
Transforming growth factor beta alters plasminogen activator activity in human skin fibroblasts.
Experimental cell research 1986;164(2):399-407.
1985: Olli Saksela; Marikki Laiho; Jorma Keski-Oja
Regulation of plasminogen activator activity in human fibroblastic cells by fibrosarcoma cell-derived factors.
Cancer research 1985;45(5):2314-9.