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Philip Laipis

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Ileana Elder; Zoë Fisher; Philip J Laipis; Chingkuang Tu; Robert McKenna; David N Silverman
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
Anatoly E Martynyuk; Deniz A Ucar; Dawn D Yang; Wendy M Norman; Paul R Carney; Donn M Dennis; Philip J Laipis
Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.
Jennifer E Embury; Catherine E Charron; Anatoly E Martynyuk; Andreas G Zori; Bin Liu; Syed F Ali; Neil E Rowland; Philip J Laipis
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.

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All Publications

2007: Ileana Elder; Zoë Fisher; Philip J Laipis; Chingkuang Tu; Robert McKenna; David N Silverman
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
Proteins 2007;68(1):337-43.
2007: Anatoly E Martynyuk; Deniz A Ucar; Dawn D Yang; Wendy M Norman; Paul R Carney; Donn M Dennis; Philip J Laipis
Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.
Epilepsia 2007;48(6):1143-50.
2007: Jennifer E Embury; Catherine E Charron; Anatoly E Martynyuk; Andreas G Zori; Bin Liu; Syed F Ali; Neil E Rowland; Philip J Laipis
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.
Brain research 2007;1127(1):136-50.
2005: Anatoly E Martynyuk; Alexander Glushakov; Colin Sumners; Philip J Laipis; Donn M Dennis; Christoph N Seubert
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism 2005;86 Suppl 1():S34-42.
2005: David M Duda; Chingkuang Tu; S Zoë Fisher; Haiqian An; Craig Yoshioka; Lakshmanan Govindasamy; Philip J Laipis; Mavis Agbandje-McKenna; David N Silverman; Robert McKenna
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.
Biochemistry 2005;44(30):10046-53.
2005: Jennifer E Embury; Roger R Reep; Philip J Laipis
Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria.
Pediatric research 2005;58(2):283-7.
2005: Alexander Glushakov; Olena Y Glushakova; Manoj Varshney; Lakshmikant Bajpai; Colin Sumners; Philip J Laipis; Jennifer E Embury; SP Baker; DH Otero; Donn M Dennis; Christoph N Seubert; Anatoly E Martynyuk
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology 2005;128(Pt 2):300-7.
2004: Sung-Hae Lee Kang; Padraic P Levings; Felicie Andersen; Philip J Laipis; Kenneth I Berns; Roberto T Zori; Jörg Bungert
Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(11):1043-53.
2004: Anil Kumar; Yu-Ping Xiao; Philip J Laipis; Bradley S Fletcher; Susan C Frost
Glucose deprivation enhances targeting of GLUT1 to lipid rafts in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2004;286(4):E568-76.
2004: Ileana Elder; Shoufa Han; Chingkuang Tu; Heather A Steele; Philip J Laipis; Ronald E Viola; David N Silverman
Activation of carbonic anhydrase II by active-site incorporation of histidine analogs.
Archives of biochemistry and biophysics 2004;421(2):283-9.
2003: Joshua J Coon; Heather A Steele; Philip J Laipis; WW Harrison
Direct atmospheric pressure coupling of polyacrylamide gel electrophoresis to mass spectrometry for rapid protein sequence analysis.
Journal of proteome research 2003;2(6):610-7.
2003: Bjarne Knudsen; Michael M Miyamoto; Philip J Laipis; David N Silverman
Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases.
Genetics 2003;164(4):1261-9.
2002: Joshua J Coon; Heather A Steele; Philip J Laipis; WW Harrison
Laser desorption-atmospheric pressure chemical ionization: a novel ion source for the direct coupling of polyacrylamide gel electrophoresis to mass spectrometry.
Journal of mass spectrometry : JMS 2002;37(11):1163-7.
2002: Chingkuang Tu; Minzhang Qian; Haiqian An; Nina R Wadhwa; David M Duda; Craig Yoshioka; Yashash Pathak; Robert McKenna; Philip J Laipis; David N Silverman
Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
The Journal of biological chemistry 2002;277(41):38870-6.
2002: Haiqian An; Chingkuang Tu; Ke Ren; Philip J Laipis; David N Silverman
Proton transfer within the active-site cavity of carbonic anhydrase III.
Biochimica et biophysica acta 2002;1599(1-2):21-7.
2002: Haiqian An; Chingkuang Tu; David M Duda; Ileana Montanez-Clemente; Kristen Math; Philip J Laipis; Robert McKenna; David N Silverman
Chemical rescue in catalysis by human carbonic anhydrases II and III.
Biochemistry 2002;41(9):3235-42.
2002: Melissa McInerney; Geidy Serrano Rodriguez; Wojciech Pawlina; Christopher B Hurt; Bradley S Fletcher; Philip J Laipis; Susan C Frost
Glycogen phosphorylase is activated in response to glucose deprivation but is not responsible for enhanced glucose transport activity in 3T3-L1 adipocytes.
Biochimica et biophysica acta 2002;1570(1):53-62.
2001: T Wingo; Chingkuang Tu; Philip J Laipis; David N Silverman
The catalytic properties of human carbonic anhydrase IX.
Biochemical and biophysical research communications 2001;288(3):666-9.
2001: Sihong Song; Jennifer E Embury; Philip J Laipis; Kenneth I Berns; James M Crawford; Terence R Flotte
Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors.
Gene therapy 2001;8(17):1299-306.
2001: Sihong Song; Philip J Laipis; Kenneth I Berns; Terence R Flotte
Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4084-8.
2001: David M Duda; Chingkuang Tu; Minzhang Qian; Philip J Laipis; Mavis Agbandje-McKenna; David N Silverman; Robert McKenna
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry 2001;40(6):1741-8.
2001: Kenneth I Berns; Patricio Ignacio Meneses; Robert M Duvoisin; Philip J Laipis; William W Hauswirth
Use of recombinant angiostatin to prevent retinal neovascularization.
Transactions of the American Clinical and Climatological Association 2001;112():68-75; discussion 75-6.
1999: Minzhang Qian; Nicole Earnhardt; N R Wadhwa; Chingkuang Tu; Philip J Laipis; David N Silverman
Proton transfer to residues of basic pK(a) during catalysis by carbonic anhydrase.
Biochimica et biophysica acta 1999;1434(1):1-5.
1999: Nicole Earnhardt; S Kirk Wright; Minzhang Qian; Chingkuang Tu; Philip J Laipis; Ronald E Viola; David N Silverman
Introduction of histidine analogs leads to enhanced proton transfer in carbonic anhydrase V.
Archives of biochemistry and biophysics 1999;361(2):264-70.
1999: Michael C Trachtenberg; C K Tu; R A Landers; R C Willson; Martin L McGregor; Philip J Laipis; J F Kennedy; M Paterson; David N Silverman; D Thomas; R L Smith; F B Rudolph
Carbon dioxide transport by proteic and facilitated transport membranes.
Life support & biosphere science : international journal of earth space 1999;6(4):293-302.
1998: Nicole Earnhardt; Minzhang Qian; Chingkuang Tu; MM Lakkis; NC Bergenhem; Philip J Laipis; Richard E Tashian; David N Silverman
The catalytic properties of murine carbonic anhydrase VII.
Biochemistry 1998;37(30):10837-45.
1998: Chingkuang Tu; Minzhang Qian; Nicole Earnhardt; Philip J Laipis; David N Silverman
Properties of intramolecular proton transfer in carbonic anhydrase III.
Biophysical journal 1998;74(6):3182-9.
1998: Nicole Earnhardt; Minzhang Qian; Chingkuang Tu; Philip J Laipis; David N Silverman
Intramolecular proton transfer from multiple sites in catalysis by murine carbonic anhydrase V.
Biochemistry 1998;37(20):7649-55.
1998: T Stams; Y Chen; P A Boriack-Sjodin; JD Hurt; John Liao; Jesse A May; Tom R Dean; Philip J Laipis; David N Silverman; David W Christianson
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein science : a publication of the Protein Society 1998;7(3):556-63.
1998: JD Hurt; Chingkuang Tu; Philip J Laipis
Isolation and expression of murine carbonic anhydrase IV.
Protein expression and purification 1998;12(1):7-16.
1997: Minzhang Qian; Chingkuang Tu; Nicole Earnhardt; Philip J Laipis; David N Silverman
Glutamate and aspartate as proton shuttles in mutants of carbonic anhydrase.
Biochemistry 1997;36(50):15758-64.
1997: JD Hurt; Chingkuang Tu; Philip J Laipis; David N Silverman
Catalytic properties of murine carbonic anhydrase IV.
The Journal of biological chemistry 1997;272(21):13512-8.
1996: R W Heck; P A Boriack-Sjodin; Minzhang Qian; Chingkuang Tu; David W Christianson; Philip J Laipis; David N Silverman
Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V.
Biochemistry 1996;35(36):11605-11.
1996: Philip J Laipis
Construction of heteroplasmic mice containing two mitochondrial DNA genotypes by micromanipulation of single-cell embryos.
Methods in enzymology 1996;264():345-57.
1995: P A Boriack-Sjodin; R W Heck; Philip J Laipis; David N Silverman; David W Christianson
Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10949-53.
1995: S M Tanhauser; Philip J Laipis
Multiple deletions are detectable in mitochondrial DNA of aging mice.
The Journal of biological chemistry 1995;270(42):24769-75.
1995: X Ren; Chingkuang Tu; Philip J Laipis; David N Silverman
Proton transfer by histidine 67 in site-directed mutants of human carbonic anhydrase III.
Biochemistry 1995;34(26):8492-8.
1994: R W Heck; S M Tanhauser; R Manda; Chingkuang Tu; Philip J Laipis; David N Silverman
Catalytic properties of mouse carbonic anhydrase V.
The Journal of biological chemistry 1994;269(40):24742-6.
1994: Chingkuang Tu; X Chen; X Ren; P V LoGrasso; David Jewell; Philip J Laipis; David N Silverman
Interactions of active-site residues and catalytic activity of human carbonic anhydrase III.
The Journal of biological chemistry 1994;269(37):23002-6.
1994: Debopam Chakrabarti; GR Reddy; John B Dame; E C Almira; Philip J Laipis; Robert J Ferl; Thomas P Yang; Thomas C Rowe; Sheldon M Schuster
Analysis of expressed sequence tags from Plasmodium falciparum.
Molecular and biochemical parasitology 1994;66(1):97-104.
1993: S Rahman; A Oberdorf; M Montecino; S M Tanhauser; Jane B Lian; Gary S Stein; Philip J Laipis; Janet L Stein
Multiple copies of the bone-specific osteocalcin gene in mouse and rat.
Endocrinology 1993;133(6):3050-3.
1993: David N Silverman; Chingkuang Tu; X Chen; S M Tanhauser; A J Kresge; Philip J Laipis
Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III.
Biochemistry 1993;32(40):10757-62.
1993: X Chen; Chingkuang Tu; P V LoGrasso; Philip J Laipis; David N Silverman
Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III.
Biochemistry 1993;32(31):7861-5.
1993: S C Ghivizzani; S L Mackay; C S Madsen; Philip J Laipis; William W Hauswirth
Transcribed heteroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region.
Journal of molecular evolution 1993;37(1):36-7.
1993: P V LoGrasso; Chingkuang Tu; X Chen; S Taoka; Philip J Laipis; David N Silverman
Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III.
Biochemistry 1993;32(22):5786-91.
1992: S M Tanhauser; David Jewell; C K Tu; David N Silverman; Philip J Laipis
A T7 expression vector optimized for site-directed mutagenesis using oligodeoxyribonucleotide cassettes.
Gene 1992;117(1):113-7.
1992: F Kraus; L Jarecki; M M Miyamoto; S M Tanhauser; Philip J Laipis
Mispairing and compensational changes during the evolution of mitochondrial ribosomal RNA.
Molecular biology and evolution 1992;9(4):770-4.
1991: R O Laine; Philip J Laipis; Neil F Shay; Michael S Kilberg
Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22.
The Journal of biological chemistry 1991;266(26):16969-72.
1991: P V LoGrasso; C K Tu; David Jewell; G C Wynns; Philip J Laipis; David N Silverman
Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine.
Biochemistry 1991;30(34):8463-70.
1991: David Jewell; C K Tu; S R Paranawithana; S M Tanhauser; P V LoGrasso; Philip J Laipis; David N Silverman
Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis.
Biochemistry 1991;30(6):1484-90.
1990: S R Paranawithana; C K Tu; Philip J Laipis; David N Silverman
Enhancement of the catalytic activity of carbonic anhydrase III by phosphates.
The Journal of biological chemistry 1990;265(36):22270-4.
1990: C K Tu; S R Paranawithana; David Jewell; S M Tanhauser; P V LoGrasso; G C Wynns; Philip J Laipis; David N Silverman
Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III.
Biochemistry 1990;29(27):6400-5.
1989: Mary Virginia Ashley; Philip J Laipis; William W Hauswirth
Rapid segregation of heteroplasmic bovine mitochondria.
Nucleic acids research 1989;17(18):7325-31.
1988: Philip J Laipis; M J Van de Walle; William W Hauswirth
Unequal partitioning of bovine mitochondrial genotypes among siblings.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8107-10.
1988: L R Eversole; Philip J Laipis
Oral squamous papillomas: detection of HPV DNA by in situ hybridization.
Oral surgery, oral medicine, and oral pathology 1988;65(5):545-50.
1987: L R Eversole; Philip J Laipis; T L Green
Human papillomavirus type 2 DNA in oral and labial verruca vulgaris.
Journal of cutaneous pathology 1987;14(6):319-25.
1987: L R Eversole; Philip J Laipis; P Merrell; E Choi
Demonstration of human papillomavirus DNA in oral condyloma acuminatum.
Journal of oral pathology 1987;16(5):266-72.
1986: G H Doran; D N Dickel; W E Ballinger; O F Agee; Philip J Laipis; William W Hauswirth
Anatomical, cellular and molecular analysis of 8,000-yr-old human brain tissue from the Windover archaeological site.
Nature 1986;323(6091):803-6.
1986: S L MacKay; Paul David Olivo; Philip J Laipis; William W Hauswirth
Template-directed arrest of mammalian mitochondrial DNA synthesis.
Molecular and cellular biology 1986;6(4):1261-7.
1986: S M Tanhauser; William W Hauswirth; Philip J Laipis
Conserved restriction sites within the ribosomal RNA genes of vertebrates.
Biochimica et biophysica acta 1986;866(1):19-25.
1984: William W Hauswirth; M J Van de Walle; Philip J Laipis; Paul David Olivo
Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue.
Cell 1984;37(3):1001-7.
1983: Paul David Olivo; M J Van de Walle; Philip J Laipis; William W Hauswirth
Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop.
Nature 1983;306(5941):400-2.
1982: G S Michaels; William W Hauswirth; Philip J Laipis
Mitochondrial DNA copy number in bovine oocytes and somatic cells.
Developmental biology 1982;94(1):246-51.
1982: William W Hauswirth; Philip J Laipis
Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4686-90.
1980: William W Hauswirth; Philip J Laipis; M E Gilman; Thomas W O'Brien; G S Michaels; M A Rayfield
Genetic mapping of bovine mitochondrial DNA from a single animal.
Gene 1980;8(2):193-209.