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Ellen Laird

Research Profile

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Procedures

X Ray Crystallography

Chemicals & Drugs

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Drug Design

Genes & Molecular Sequences

Molecular Structure

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Publications

TOP 3
Steve Wenglowsky; Susan L Gloor; Ellen R Laird; David Moreno; Li Ren; Tyler Risom; Joachim Rudolph; Hillary L Sturgis; Walter C Voegtli
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.
Li Ren; Tyler Risom; Hillary L Sturgis; Walter C Voegtli; Steve Wenglowsky; David Moreno; Bradley Newhouse; Sumeet Rana; Kevin Rasor; Kateri A Ahrendt; Alex J Buckmelter; Victoria Dinkel; Susan L Gloor; Jonas Grina; Joshua D Hansen; Gregg Hastings; Ellen R Laird; Simon Mathieu
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.
Simon Mathieu; David Moreno; Rebecca Pulk; Yingqing Ran; Li Ren; Walter C Voegtli; Zhaoyang Wen; Steve Wenglowsky; Guiling Zhao; Ignacio Aliagas; Bruno Alicke; Jason W Boggs; Alex J Buckmelter; Edna F Choo; Victoria Dinkel; Susan L Gloor; Stephen E Gould; Stefan N Gradl; Jonas Grina; Janet Gunzner-Toste; Joshua D Hansen; Gregg Hastings; Georgia Hatzivassiliou; Ellen R Laird; Wendy Lee; Joachim Rudolph
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.

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All Publications

2012: Steve Wenglowsky; Susan L Gloor; Ellen R Laird; David Moreno; Li Ren; Tyler Risom; Joachim Rudolph; Hillary L Sturgis; Walter C Voegtli
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(19):6237-41.
2012: Li Ren; Tyler Risom; Hillary L Sturgis; Walter C Voegtli; Steve Wenglowsky; David Moreno; Bradley Newhouse; Sumeet Rana; Kevin Rasor; Kateri A Ahrendt; Alex J Buckmelter; Victoria Dinkel; Susan L Gloor; Jonas Grina; Joshua D Hansen; Gregg Hastings; Ellen R Laird; Simon Mathieu
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.
Bioorganic & medicinal chemistry letters 2012;22(10):3387-91.
2012: Simon Mathieu; David Moreno; Rebecca Pulk; Yingqing Ran; Li Ren; Walter C Voegtli; Zhaoyang Wen; Steve Wenglowsky; Guiling Zhao; Ignacio Aliagas; Bruno Alicke; Jason W Boggs; Alex J Buckmelter; Edna F Choo; Victoria Dinkel; Susan L Gloor; Stephen E Gould; Stefan N Gradl; Jonas Grina; Janet Gunzner-Toste; Joshua D Hansen; Gregg Hastings; Georgia Hatzivassiliou; Ellen R Laird; Wendy Lee; Joachim Rudolph
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.
Journal of medicinal chemistry 2012;55(6):2869-81.
2011: Steve Wenglowsky; Kateri A Ahrendt; Alex J Buckmelter; Bainian Feng; Susan L Gloor; Stefan Gradl; Jonas Grina; Joshua D Hansen; Ellen R Laird; Paul Lunghofer; Simon Mathieu; David Moreno; Bradley Newhouse; Li Ren; Tyler Risom; Joachim Rudolph; Jeongbeob Seo; Hillary L Sturgis; Walter C Voegtli; Zhaoyang Wen
Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.
Bioorganic & medicinal chemistry letters 2011;21(18):5533-7.
2011: Bradley Newhouse; Joshua D Hansen; Jonas Grina; Mike Welch; George Topalov; Nicole Littman; Michele Callejo; Matthew Martinson; Sarah Galbraith; Ellen R Laird; Barbara J Brandhuber; Guy Vigers; Tony Morales; Rich Woessner; Nikole Randolph; Joseph Lyssikatos; Alan Olivero
Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bioorganic & medicinal chemistry letters 2011;21(11):3488-92.
2011: Li Ren; Steve Wenglowsky; Greg Miknis; Bryson Rast; Alex J Buckmelter; Robert J Ely; Stephen Schlachter; Ellen R Laird; Nikole Randolph; Michele Callejo; Matthew Martinson; Sarah Galbraith; Barbara J Brandhuber; Guy Vigers; Tony Morales; Walter C Voegtli; Joseph Lyssikatos
Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorganic & medicinal chemistry letters 2011;21(4):1243-7.
2011: Alex J Buckmelter; Li Ren; Ellen R Laird; Bryson Rast; Greg Miknis; Steve Wenglowsky; Stephen Schlachter; Mike Welch; Eugene Tarlton; Jonas Grina; Joseph Lyssikatos; Barbara J Brandhuber; Tony Morales; Nikole Randolph; Guy Vigers; Matthew Martinson; Michele Callejo
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(4):1248-52.
2009: Ralph P Robinson; Leonard Buckbinder; Amber I Haugeto; Patricia A McNiff; Michele L Millham; Matthew R Reese; Jean F Schaefer; Yuriy A Abramov; Jon Bordner; Yves A Chantigny; Edward F Kleinman; Ellen R Laird; Bradley P Morgan; John C Murray; Eben D Salter; Matthew D Wessel; Sue A Yocum
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.
Journal of medicinal chemistry 2009;52(6):1731-43.
2007: Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2007;17(23):6529-34.
2007: C Todd Eary; Zachary S Jones; Robert D Groneberg; Laurence E Burgess; David A Mareska; Mark D Drew; James F Blake; Ellen R Laird; Devan Balachari; Michael O'Sullivan; Andrew Allen; Vivienne Marsh
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2608-13.
2007: Derin C D'Amico; Toshi Aya; Jason Human; Christopher Fotsch; Jian Jeffrey Chen; Kaustav Biswas; Bobby Riahi; Mark H Norman; Christopher A Willoughby; Randall W Hungate; Paul J Reider; Gloria Biddlecome; Dianna Lester-Zeiner; Carlo Van Staden; Eileen Johnson; Augustus Kamassah; Leyla Arik; Judy Wang; Vellarkad Viswanadhan; Robert D Groneberg; James Zhan; Hideo Suzuki; Andras Toro; David A Mareska; David E Clarke; Darren M Harvey; Laurence E Burgess; Ellen R Laird; Benny C Askew; Gordon Ng
Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.
Journal of medicinal chemistry 2007;50(4):607-10.
2006: Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2006;16(22):5822-6.
2005: Kim F McClure; Yuriy A Abramov; Ellen R Laird; John T Barberia; Weiling Cai; Thomas J Carty; Santo R Cortina; dennis danley; Alan J Dipesa; Kathleen M Donahue; Mark A Dombroski; Nancy C Elliott; Christopher A Gabel; Seungil Han; THOMAS HYNES; Peter K LeMotte; Mahmoud N Mansour; Eric S Marr; Michael A Letavic; Jayvardhan Pandit; David B Ripin; Francis J Sweeney; Douglas Tan; Yong Tao
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.
Journal of medicinal chemistry 2005;48(18):5728-37.
2005: Julian A Blagg; Mark C Noe; Lilli A Wolf-Gouveia; Lawrence A Reiter; Ellen R Laird; Shang-Poa P Chang; dennis danley; James T Downs; Nancy C Elliott; James D Eskra; Richard J Griffiths; Joel R Hardink; Amber I Haugeto; Christopher S Jones; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Ralph P Robinson; Chakrapani Subramanyam; Marcie L Vaughn-Bowser; Sue A Yocum
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Bioorganic & medicinal chemistry letters 2005;15(7):1807-10.
2004: Bradley Newhouse; Shelley Allen; Benjamin Fauber; Aaron S Anderson; C Todd Eary; Joshua D Hansen; Justin Schiro; John J Gaudino; Ellen R Laird; David Chantry; Christine Eberhardt; Laurence E Burgess
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(22):5537-42.
2004: Ellen R Laird; James F Blake
Structure-based generation of viable leads from small combinatorial libraries.
Current opinion in drug discovery & development 2004;7(3):354-9.
2003: Thomas A Pauly; Traian Sulea; Mark J Ammirati; J Sivaraman; dennis danley; Matthew C Griffor; Ajith V Kamath; Ing-Kae Wang; Ellen R Laird; Andrew P Seddon; Robert Ménard; Miroslaw Cygler; Virginia L Rath
Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry 2003;42(11):3203-13.
2002: Michael A Letavic; Matt Z Axt; John T Barberia; Thomas J Carty; dennis danley; Kieran F Geoghegan; Nadia S Halim; Lise R Hoth; Ajith V Kamath; Ellen R Laird; Lori L Lopresti-Morrow; Kim F McClure; Peter G Mitchell; Vijayalakshmi Natarajan; Mark C Noe; Jayvardhan Pandit; Lisa M Reeves; Gayle K Schulte; Sheri L Snow; Francis J Sweeney; Douglas H Tan; Chul H Yu
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(10):1387-90.
2001: Ralph P Robinson; Ellen R Laird; Kathleen M Donahue; Lori L Lopresti-Morrow; Peter G Mitchell; Matthew R Reese; Lisa M Reeves; A I Rouch; Ethan J Stam; Sue A Yocum
Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(9):1211-3.
2000: Ralph P Robinson; Ellen R Laird; James F Blake; Jon Bordner; Kathleen M Donahue; Lori L Lopresti-Morrow; Peter G Mitchell; Matthew R Reese; Lisa M Reeves; Ethan J Stam; Sue A Yocum
Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.
Journal of medicinal chemistry 2000;43(12):2293-6.
1999: Lawrence A Reiter; J P Rizzi; Jayvardhan Pandit; M J Lasut; S M McGahee; V D Parikh; James F Blake; dennis danley; Ellen R Laird; Arturo Lopez-Anaya; Lori L Lopresti-Morrow; Mahmoud N Mansour; Gary J Martinelli; Peter G Mitchell; B S Owens; Thomas A Pauly; Lisa M Reeves; Gayle K Schulte; Sue A Yocum
Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.
Bioorganic & medicinal chemistry letters 1999;9(2):127-32.

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