Edward Lakatta

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Zhou Peng; Zhao Yan-Ting; Guo Yun-Bo; Xu Shi-Ming; Bai Shu-Hua; Lakatta Edward G; Cheng Heping; Hao Xue-Mei; Wang Shi-Qiang
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
Ahmet Ismail; Morrell Chris; Lakatta Edward G; Talan Mark I
Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor.
Vinogradova Tatiana M; Lakatta Edward G
Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.

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All Publications

2009: Zhou Peng; Zhao Yan-Ting; Guo Yun-Bo; Xu Shi-Ming; Bai Shu-Hua; Lakatta Edward G; Cheng Heping; Hao Xue-Mei; Wang Shi-Qiang
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):18028-33.
2009: Ahmet Ismail; Morrell Chris; Lakatta Edward G; Talan Mark I
Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor.
The Journal of pharmacology and experimental therapeutics 2009;331(1):178-85.
2009: Vinogradova Tatiana M; Lakatta Edward G
Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.
Journal of molecular and cellular cardiology 2009;47(4):456-74.
2009: Chantler Paul D; Lakatta Edward G
Role of body size on cardiovascular function: can we see the meat through the fat?
Hypertension 2009;54(3):459-61.
2009: Lyashkov Alexey E; Vinogradova Tatiana M; Zahanich Ihor; Li Yue; Younes Antoine; Nuss H Bradley; Spurgeon Harold A; Maltsev Victor A; Lakatta Edward G
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
American journal of physiology. Heart and circulatory physiology 2009;297(3):H949-59.
2009: Lakatta Edward G; DiFrancesco Dario
What keeps us ticking: a funny current, a calcium clock, or both?
Journal of molecular and cellular cardiology 2009;47(2):157-70.
2009: Pang John; Zeng Xiaokun; Xiao Rui-ping; Lakatta Edward G; Lin Li
Design, generation, and testing of mammalian expression modules that tag membrane proteins.
Protein science : a publication of the Protein Society 2009;18(6):1261-71.
2009: Fu Zongming; Wang Mingyi; Gucek Marjan; Zhang Jing; Wu James; Jiang Liqun; Monticone Robert E; Khazan Benjamin; Telljohann Richard; Mattison Julie; Sheng Simon; Cole Robert N; Spinetti Gaia; Pintus Gianfranco; Liu Lijuan; Kolodgie Frank D; Virmani Renu; Spurgeon Harold; Ingram Donald K; Everett Allen D; Lakatta Edward G; Van Eyk Jennifer E
Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion.
Circulation research 2009;104(12):1337-46.
2009: Lakatta Edward G; Wang Mingyi; Najjar Samer S
Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.
The Medical clinics of North America 2009;93(3):583-604, Table of Contents.
2009: Brinkley Tina E; Nicklas Barbara J; Kanaya Alka M; Satterfield Suzanne; Lakatta Edward G; Simonsick Eleanor M; Sutton-Tyrrell Kim; Kritchevsky Stephen B
Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study.
Hypertension 2009;53(5):846-52.
2009: Scuteri Angelo; Morrell Christopher H; Najjar Samer S; Muller Denis; Andres Reubin; Ferrucci Luigi; Lakatta Edward G
Longitudinal paths to the metabolic syndrome: can the incidence of the metabolic syndrome be predicted? The Baltimore Longitudinal Study of Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(5):590-8.
2009: Strait James B; Uda Manuela; Lakatta Edward G; Najjar Samer S
Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
Trends in cardiovascular medicine 2009;19(3):69-75.
2009: Wang Kang-Ling; Cheng Hao-Min; Chuang Shao-Yuan; Spurgeon Harold A; Ting Chih-Tai; Lakatta Edward G; Yin Frank C P; Chou Pesus; Chen Chen-Huan
Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
Journal of hypertension 2009;27(3):461-7.
2009: Maltsev Victor A; Lakatta Edward G
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H594-615.
2009: Wang Mingyi; Lakatta Edward G
The salted artery and angiotensin II signaling: a deadly duo in arterial disease.
Journal of hypertension 2009;27(1):19-21.
2009: Lin Li; Park Sungha; Lakatta Edward G
RAGE signaling in inflammation and arterial aging.
Frontiers in bioscience : a journal and virtual library 2009;14():1403-13.
2009: Wang Su; Ziman Bruce; Bodi Ilona; Rubio Marta; Zhou Ying-Ying; D'Souza Karen; Bishopric Nanette H; Schwartz Arnold; Lakatta Edward G
Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse.
PloS one 2009;4(1):e4133.
2008: Fedorova Olga V; Simbirtsev Andrey S; Kolodkin Nikolai I; Kotov Alexander Y; Agalakova Natalia I; Kashkin Vladimir A; Tapilskaya Natalia I; Bzhelyansky Anton; Reznik Vitaly A; Frolova Elena V; Nikitina Elena R; Budny Georgy V; Longo Dan L; Lakatta Edward G; Bagrov Alexei Y
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.
Journal of hypertension 2008;26(12):2414-25.
2008: Lakatta Edward G
Arterial aging is risky.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1321-2.
2008: Chantler Paul D; Lakatta Edward G; Najjar Samer S
Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1342-51.
2008: Csiszar Anna; Wang Mingyi; Lakatta Edward G; Ungvari Zoltan
Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1333-41.
2008: Wang Wang; Fang Huaqiang; Groom Linda; Cheng Aiwu; Zhang Wanrui; Liu Jie; Wang Xianhua; Li Kaitao; Han Peidong; Zheng Ming; Yin Jinhu; Wang Weidong; Mattson Mark P; Kao Joseph P Y; Lakatta Edward G; Sheu Shey-Shing; Ouyang Kunfu; Chen Ju; Dirksen Robert T; Cheng Heping
Superoxide flashes in single mitochondria.
Cell 2008;134(2):279-90.
2008: Chantler Paul D; Melenovsky Vojtech; Schulman Steven P; Gerstenblith Gary; Becker Lewis C; Ferrucci Luigi; Fleg Jerome L; Lakatta Edward G; Najjar Samer S
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H145-53.
2008: Younes Antoine; Lyashkov Alexey E; Graham David; Sheydina Anna; Volkova Maria V; Mitsak Megan; Vinogradova Tatiana M; Lukyanenko Yevgeniya O; Li Yue; Ruknudin Abdul M; Boheler Kenneth R; van Eyk Jennifer; Lakatta Edward G
Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.
The Journal of biological chemistry 2008;283(21):14461-8.
2008: Ahmet Ismayil; Krawczyk Melissa; Zhu Weizhong; Woo Anthony Yiu-Ho; Morrell Christopher; Poosala Suresh; Xiao Riu-Ping; Lakatta Edward G; Talan Mark I
Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.
The Journal of pharmacology and experimental therapeutics 2008;325(2):491-9.
2008: Najjar Samer S; Scuteri Angelo; Shetty Veena; Wright Jeanette G; Muller Denis C; Fleg Jerome L; Spurgeon Harold P; Ferrucci Luigi; Lakatta Edward G
Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.
Journal of the American College of Cardiology 2008;51(14):1377-83.
2008: Anderson David E; Fedorova Olga V; Morrell Christopher H; Longo Dan L; Kashkin Vladimir A; Metzler Jessica D; Bagrov Alexei Y; Lakatta Edward G
Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1248-54.
2008: Vinogradova Tatiana M; Sirenko Syevda; Lyashkov Alexey E; Younes Antoine; Li Yue; Zhu Weizhong; Yang Dongmei; Ruknudin Abdul M; Spurgeon Harold; Lakatta Edward G
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.
Circulation research 2008;102(7):761-9.
2008: Lakatta Edward G; Vinogradova Tatiana M; Maltsev Victor A
The missing link in the mystery of normal automaticity of cardiac pacemaker cells.
Annals of the New York Academy of Sciences 2008;1123():41-57.
2008: Farasat S Morteza; Morrell Christopher H; Scuteri Angelo; Ting Chih-Tai; Yin Frank C P; Spurgeon Harold A; Chen Chen-Huan; Lakatta Edward G; Najjar Samer S
Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension.
Hypertension 2008;51(2):196-202.
2008: Maltsev Victor A; Lakatta Edward G
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function.
Cardiovascular research 2008;77(2):274-84.
2008: Kashkin Vladimir A; Zvartau Edwin E; Fedorova Olga V; Bagrov Yakov Y; Lakatta Edward G; Bagrov Alexei Y
Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(1):74-7.
2008: Jiang Liqun; Wang Mingyi; Zhang Jing; Monticone Robert E; Telljohann Richard; Spinetti Gaia; Pintus Gianfranco; Lakatta Edward G
Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells.
PloS one 2008;3(5):e2231.
2007: McConville Patrick; Lakatta Edward G; Spencer Richard G
Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1828-35.
2007: Zahn Jacob M; Poosala Suresh; Owen Art B; Ingram Donald K; Lustig Ana; Carter Arnell; Weeraratna Ashani T; Taub Dennis D; Gorospe Myriam; Mazan-Mamczarz Krystyna; Lakatta Edward G; Boheler Kenneth R; Xu Xiangru; Mattson Mark P; Falco Geppino; Ko Minoru S H; Schlessinger David; Firman Jeffrey; Kummerfeld Sarah K; Wood William H; Zonderman Alan B; Kim Stuart K; Becker Kevin G
AGEMAP: a gene expression database for aging in mice.
PLoS genetics 2007;3(11):e201.
2007: Maltsev Victor A; Lakatta Edward G
Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells.
Heart, lung & circulation 2007;16(5):335-48.
2007: Fedorova Olga V; Zhuravin Igor A; Agalakova Natalia I; Yamova Liubov A; Talan Mark I; Lakatta Edward G; Bagrov Alexei Y
Intrahippocampal microinjection of an exquisitely low dose of ouabain mimics NaCl loading and stimulates a bufadienolide Na/K-ATPase inhibitor.
Journal of hypertension 2007;25(9):1834-44.
2007: Wang Mingyi; Zhang Jing; Jiang Li-Qun; Spinetti Gaia; Pintus Gianfranco; Monticone Robert; Kolodgie Frank D; Virmani Renu; Lakatta Edward G
Proinflammatory profile within the grossly normal aged human aortic wall.
Hypertension 2007;50(1):219-27.
2007: Lyashkov Alexey E; Juhaszova Magdalena; Dobrzynski Halina; Vinogradova Tatiana M; Maltsev Victor A; Juhasz Ondrej; Spurgeon Harold A; Sollott Steven J; Lakatta Edward G
Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size.
Circulation research 2007;100(12):1723-31.
2007: Ruknudin Abdul M; Lakatta Edward G
The regulation of the Na/Ca exchanger and plasmalemmal Ca2+ ATPase by other proteins.
Annals of the New York Academy of Sciences 2007;1099():86-102.
2007: Costa Paul T; Terracciano Antonio; Uda Manuela; Vacca Loredana; Mameli Cinzia; Pilia Giuseppe; Zonderman Alan B; Lakatta Edward; Schlessinger David; McCrae Robert R
Personality traits in Sardinia: testing founder population effects on trait means and variances.
Behavior genetics 2007;37(2):376-87.
2007: Yang Dongmei; Zhu Wei-Zhong; Xiao Bailong; Brochet Didier X P; Chen S R Wayne; Lakatta Edward G; Xiao Rui-Ping; Cheng Heping
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Circulation research 2007;100(3):399-407.
2007: Maltsev Victor A; Lakatta Edward G
Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia.
Journal of molecular and cellular cardiology 2007;42(2):289-94.
2007: Melenovsky Vojtech; Borlaug Barry A; Rosen Boaz; Hay Ilan; Ferruci Luigi; Morell Christopher H; Lakatta Edward G; Najjar Samer S; Kass David A
Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction.
Journal of the American College of Cardiology 2007;49(2):198-207.
2006: Fedorova Olga V; Agalakova Natalia I; Morrell Christopher H; Lakatta Edward G; Bagrov Alexei Y
ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta.
Hypertension 2006;48(6):1160-8.
2006: Baur Joseph A; Pearson Kevin J; Price Nathan L; Jamieson Hamish A; Lerin Carles; Kalra Avash; Prabhu Vinayakumar V; Allard Joanne S; Lopez-Lluch Guillermo; Lewis Kaitlyn; Pistell Paul J; Poosala Suresh; Becker Kevin G; Boss Olivier; Gwinn Dana; Wang Mingyi; Ramaswamy Sharan; Fishbein Kenneth W; Spencer Richard G; Lakatta Edward G; Le Couteur David; Shaw Reuben J; Navas Placido; Puigserver Pere; Ingram Donald K; de Cabo Rafael; Sinclair David A
Resveratrol improves health and survival of mice on a high-calorie diet.
Nature 2006;444(7117):337-42.
2006: Lakatta Edward G; Vinogradova Tatiana; Lyashkov Alexey; Sirenko Syevda; Zhu Weizong; Ruknudin Abdul; Maltsev Victor A
The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.
Annals of the New York Academy of Sciences 2006;1080():178-206.
2006: Bogdanov Konstantin Y; Maltsev Victor A; Vinogradova Tatiana M; Lyashkov Alexey E; Spurgeon Harold A; Stern Michael D; Lakatta Edward G
Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state.
Circulation research 2006;99(9):979-87.
2006: Moon Chanil; Krawczyk Melissa; Lakatta Edward G; Talan Mark I
Therapeutic effectiveness of a single vs multiple doses of erythropoietin after experimental myocardial infarction in rats.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(4):245-51.
2006: Pilia Giuseppe; Chen Wei-Min; Scuteri Angelo; Orrú Marco; Albai Giuseppe; Dei Mariano; Lai Sandra; Usala Gianluca; Lai Monica; Loi Paola; Mameli Cinzia; Vacca Loredana; Deiana Manila; Olla Nazario; Masala Marco; Cao Antonio; Najjar Samer S; Terracciano Antonio; Nedorezov Timur; Sharov Alexei; Zonderman Alan B; Abecasis Gonçalo R; Costa Paul; Lakatta Edward; Schlessinger David
Heritability of cardiovascular and personality traits in 6,148 Sardinians.
PLoS genetics 2006;2(8):e132.
2006: Wang Mingyi; Zhao Di; Spinetti Gaia; Zhang Jing; Jiang Li-Qun; Pintus Gianfranco; Monticone Robert; Lakatta Edward G
Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1503-9.
2006: Xiao Rui-Ping; Zhu Weizhong; Zheng Ming; Cao Chunmei; Zhang Youyi; Lakatta Edward G; Han Qide
Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart.
Trends in pharmacological sciences 2006;27(6):330-7.
2006: Lakatta Edward G; Chantler Paul D
Payments for debts associated with exercise can become higher as we age and limit exercise capacity.
Journal of the American College of Cardiology 2006;47(5):1058-9.
2006: Kennedy David J; Vetteth Sandeep; Periyasamy Sankaridrug M; Kanj Mohamed; Fedorova Larisa; Khouri Samer; Kahaleh M Bashar; Xie Zijian; Malhotra Deepak; Kolodkin Nikolai I; Lakatta Edward G; Fedorova Olga V; Bagrov Alexei Y; Shapiro Joseph I
Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.
Hypertension 2006;47(3):488-95.
2006: Vinogradova Tatiana M; Lyashkov Alexey E; Zhu Weizhong; Ruknudin Abdul M; Sirenko Syevda; Yang Dongmei; Deo Shekhar; Barlow Matthew; Johnson Shavsha; Caffrey James L; Zhou Ying-Ying; Xiao Rui-Ping; Cheng Heping; Stern Michael D; Maltsev Victor A; Lakatta Edward G
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Circulation research 2006;98(4):505-14.
2006: Moon Chanil; Krawczyk Melissa; Paik Doojin; Coleman Thomas; Brines Michael; Juhaszova Magdalena; Sollott Steven J; Lakatta Edward G; Talan Mark I
Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties.
The Journal of pharmacology and experimental therapeutics 2006;316(3):999-1005.
2006: Hougaku Hidetaka; Fleg Jerome L; Najjar Samer S; Lakatta Edward G; Harman S Mitchell; Blackman Marc R; Metter E Jeffrey
Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements.
American journal of physiology. Endocrinology and metabolism 2006;290(2):E234-42.
2006: Averina I V; Tapilskaya N I; Reznik V A; Frolova E V; Fedorova O V; Lakatta E G; Bagrov A Y
Endogenous Na/K-ATPase inhibitors in patients with preeclampsia.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(8):19-23.
2006: Maltsev Victor A; Vinogradova Tatiana M; Lakatta Edward G
The emergence of a general theory of the initiation and strength of the heartbeat.
Journal of pharmacological sciences 2006;100(5):338-69.
2005: Ahmet Ismayil; Lakatta Edward G; Talan Mark I
Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy.
Heart failure reviews 2005;10(4):289-96.
2005: Ahmet Ismayil; Wan Ruiqian; Mattson Mark P; Lakatta Edward G; Talan Mark
Cardioprotection by intermittent fasting in rats.
Circulation 2005;112(20):3115-21.
2005: Wang Mingyi; Zhang Jing; Spinetti Gaia; Jiang Li-Qun; Monticone Robert; Zhao Di; Cheng Linda; Krawczyk Melissa; Talan Mark; Pintus Gianfranco; Lakatta Edward G
Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.
The American journal of pathology 2005;167(5):1429-42.
2005: Younès Antoine; Pepe Salvatore; Yoshishige Darice; Caffrey James L; Lakatta Edward G
Ischemic preconditioning increases the bioavailability of cardiac enkephalins.
American journal of physiology. Heart and circulatory physiology 2005;289(4):H1652-61.
2005: Najjar Samer S; Scuteri Angelo; Lakatta Edward G
Arterial aging: is it an immutable cardiovascular risk factor?
Hypertension 2005;46(3):454-62.
2005: McConville P; Spencer R G; Lakatta E G
Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1- and beta2-AR stimulation in the isolated, perfused rat heart.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E412-8.
2005: Moon Chanil; Krawczyk Melissa; Paik Doojin; Lakatta Edward G; Talan Mark I
Cardioprotection by recombinant human erythropoietin following acute experimental myocardial infarction: dose response and therapeutic window.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2005;19(4):243-50.
2005: Havlik Richard J; Phillips Caroline L; Brock Dwight B; Lohman Kurt; Haskell William; Snell Peter; O'Toole Mary; Ribisl Paul; Vaitkevicius Peter; Spurgeon Harold A; Lakatta Edward G; Pullen Paul
Walking may be related to less vascular stiffness in the Activity Counseling Trial (ACT).
American heart journal 2005;150(2):270-5.
2005: Fleg Jerome L; Morrell Christopher H; Bos Angelo G; Brant Larry J; Talbot Laura A; Wright Jeanette G; Lakatta Edward G
Accelerated longitudinal decline of aerobic capacity in healthy older adults.
Circulation 2005;112(5):674-82.
2005: Fedorova Olga V; Agalakova Natalia I; Talan Mark I; Lakatta Edward G; Bagrov Alexei Y
Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats.
Journal of hypertension 2005;23(8):1515-23.
2005: Zhu Wei-Zhong; Chakir Khalid; Zhang Shengjun; Yang Dongmei; Lavoie Catherine; Bouvier Michel; Hébert Terence E; Lakatta Edward G; Cheng Heping; Xiao Rui-Ping
Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.
Circulation research 2005;97(3):244-51.
2005: Scuteri Angelo; Najjar Samer S; Muller Denis; Andres Reubin; Morrell Christopher H; Zonderman Alan B; Lakatta Edward G
apoE4 allele and the natural history of cardiovascular risk factors.
American journal of physiology. Endocrinology and metabolism 2005;289(2):E322-7.
2005: Vinogradova Tatiana M; Maltsev Victor A; Bogdanov Konstantin Y; Lyashkov Alexey E; Lakatta Edward G
Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.
Annals of the New York Academy of Sciences 2005;1047():138-56.
2005: Sutton-Tyrrell Kim; Najjar Samer S; Boudreau Robert M; Venkitachalam Lakshmi; Kupelian Varant; Simonsick Eleanor M; Havlik Richard; Lakatta Edward G; Spurgeon Harold; Kritchevsky Stephen; Pahor Marco; Bauer Douglas; Newman Anne;
Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
Circulation 2005;111(25):3384-90.
2005: Sanbe Atsushi; James Jeanne; Tuzcu Volkan; Nas Selman; Martin Lisa; Gulick James; Osinska Hanna; Sakthivel Sadayappan; Klevitsky Raisa; Ginsburg Kenneth S; Bers Donald M; Zinman Bruce; Lakatta Edward G; Robbins Jeffrey
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.
Circulation 2005;111(18):2330-8.
2005: Juhaszova Magdalena; Rabuel Christophe; Zorov Dmitry B; Lakatta Edward G; Sollott Steven J
Protection in the aged heart: preventing the heart-break of old age?
Cardiovascular research 2005;66(2):233-44.
2005: Pepe Salvatore; Lakatta Edward G
Aging hearts and vessels: masters of adaptation and survival.
Cardiovascular research 2005;66(2):190-3.
2005: Hougaku Hidetaka; Fleg Jerome L; Lakatta Edward G; Scuteri Angelo; Earley Christopher J; Najjar Samer; Deb Saswata; Metter E Jeffrey
Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening.
The American journal of cardiology 2005;95(8):1006-10.
2005: Scuteri Angelo; Najjar Samer S; Morrell Christopher H; Lakatta Edward G;
The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study.
Diabetes care 2005;28(4):882-7.
2005: Fedorova Olga V; Kolodkin Nikolai I; Agalakova Natalia I; Namikas Alexandra R; Bzhelyansky Anton; St-Louis Jean; Lakatta Edward G; Bagrov Alexei Y
Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake.
Journal of hypertension 2005;23(4):835-42.
2005: Kobrinsky Evgeny; Tiwari Swasti; Maltsev Victor A; Harry Jo Beth; Lakatta Edward; Abernethy Darrell R; Soldatov Nikolai M
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.
The Journal of biological chemistry 2005;280(13):12474-85.
2005: Boluyt Marvin O; Robinson Kathleen G; Meredith Andrea L; Sen Subha; Lakatta Edward G; Crow Michael T; Brooks Wesley W; Conrad Chester H; Bing Oscar H L
Heart failure after long-term supravalvular aortic constriction in rats.
American journal of hypertension 2005;18(2 Pt 1):202-12.
2005: Hadley Evan C; Lakatta Edward G; Morrison-Bogorad Marcelle; Warner Huber R; Hodes Richard J
The future of aging therapies.
Cell 2005;120(4):557-67.
2004: Wu Guimei; Marín-García José; Rogers Terry B; Lakatta Edward G; Long Xilin
Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes.
Journal of cardiac failure 2004;10(6):519-26.
2004: Leblais Veronique; Jo Su-Hyun; Chakir Khalid; Maltsev Victor; Zheng Ming; Crow Michael T; Wang Wang; Lakatta Edward G; Xiao Rui-Ping
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Circulation research 2004;95(12):1183-90.
2004: Najjar Samer S; Schulman Steven P; Gerstenblith Gary; Fleg Jerome L; Kass David A; O'Connor Frances; Becker Lewis C; Lakatta Edward G
Age and gender affect ventricular-vascular coupling during aerobic exercise.
Journal of the American College of Cardiology 2004;44(3):611-7.
2004: Ahmet Ismayil; Krawczyk Melissa; Heller Phillip; Moon Chanil; Lakatta Edward G; Talan Mark I
Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy.
Circulation 2004;110(9):1083-90.
2004: Pepe Salvatore; van den Brink Olivier W V; Lakatta Edward G; Xiao Rui-Ping
Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart.
Cardiovascular research 2004;63(3):414-22.
2004: Spinetti Gaia; Wang Mingyi; Monticone Robert; Zhang Jing; Zhao Di; Lakatta Edward G
Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1397-402.
2004: Lakatta Edward G; Schulman Steven
Age-associated cardiovascular changes are the substrate for poor prognosis with myocardial infarction.
Journal of the American College of Cardiology 2004;44(1):35-7.
2004: Xiao Rui-Ping; Zhu Weizhong; Zheng Ming; Chakir Khalid; Bond Richard; Lakatta Edward G; Cheng Heping
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.
Trends in pharmacological sciences 2004;25(7):358-65.
2004: Bagrov Alexei Y; Lakatta Edward G
The dietary sodium-blood pressure plot "stiffens".
Hypertension 2004;44(1):22-4.
2004: Lakatta Edward G
Beyond Bowditch: the convergence of cardiac chronotropy and inotropy.
Cell calcium 2004;35(6):629-42.
2004: Scuteri Angelo; Najjar Samer S; Muller Denis C; Andres Reubin; Hougaku Hidetaka; Metter E Jeffrey; Lakatta Edward G
Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness.
Journal of the American College of Cardiology 2004;43(8):1388-95.
2004: Maltsev Victor A; Vinogradova Tatiana M; Bogdanov Konstantin Y; Lakatta Edward G; Stern Michael D
Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.
Biophysical journal 2004;86(4):2596-605.
2004: Vinogradova Tatiana M; Zhou Ying-Ying; Maltsev Victor; Lyashkov Alexey; Stern Michael; Lakatta Edward G
Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization.
Circulation research 2004;94(6):802-9.
2004: Braz Julian C; Gregory Kimberly; Pathak Anand; Zhao Wen; Sahin Bogachan; Klevitsky Raisa; Kimball Thomas F; Lorenz John N; Nairn Angus C; Liggett Stephen B; Bodi Ilona; Wang Su; Schwartz Arnold; Lakatta Edward G; DePaoli-Roach Anna A; Robbins Jeffrey; Hewett Timothy E; Bibb James A; Westfall Margaret V; Kranias Evangelia G; Molkentin Jeffery D
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Ahn Dongchoon; Cheng Linda; Moon Chanil; Spurgeon Harold; Lakatta Edward G; Talan Mark I
Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice.
American journal of physiology. Heart and circulatory physiology 2004;286(3):H1201-7.
2004: Guangqin Zhang; Yu Fu; Dongmei Yang; Xuemei Hao; Shuhua Bai; Yiqun Tang; Lakatta Edward G; Caihong Wu; Heping Cheng
Contribution of spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocytes.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2004;47(1):31-7.
2004: Fedorova Olga V; Talan Mark I; Agalakova Natalia I; Lakatta Edward G; Bagrov Alexei Y
Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.
Journal of hypertension 2004;22(2):389-97.
2004: Scuteri Angelo; Manolio Teri A; Marino Emily K; Arnold Alice M; Lakatta Edward G
Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131).
Journal of the American College of Cardiology 2004;43(2):187-93.
2003: Scuteri Angelo; Lakatta Edward G; Anderson David E; Fleg Jerome L
Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal women.
Journal of hypertension 2003;21(12):2419-20.
2003: Wildman Scott S; Hooper Kimberly M; Turner Clare M; Sham James S K; Lakatta Edward G; King Brian F; Unwin Robert J; Sutters Michael
The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry.
American journal of physiology. Renal physiology 2003;285(6):F1168-78.
2003: Moon Chanil; Krawczyk Melissa; Ahn Dongchoon; Ahmet Ismayil; Paik Doojin; Lakatta Edward G; Talan Mark I
Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11612-7.
2003: Xiao Rui-Ping; Zhang Sheng-Jun; Chakir Khalid; Avdonin Pavel; Zhu Weizhong; Bond Richard A; Balke C William; Lakatta Edward G; Cheng Heping
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Circulation 2003;108(13):1633-9.
2003: Scuteri Angelo; Stuehlinger Markus C; Cooke John P; Wright Jeanette G; Lakatta Edward G; Anderson David E; Fleg Jerome L
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women.
Journal of hypertension 2003;21(7):1339-46.
2003: Wang Mingyi; Takagi Gen; Asai Kuniya; Resuello Ranilo G; Natividad Filipinas F; Vatner Dorothy E; Vatner Stephen F; Lakatta Edward G
Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates.
Hypertension 2003;41(6):1308-16.
2003: McConville Patrick; Fishbein Kenneth W; Lakatta Edward G; Spencer Richard G S
Differences in the bioenergetic response of the isolated perfused rat heart to selective beta1- and beta2-adrenergic receptor stimulation.
Circulation 2003;107(16):2146-52.
2003: Shivakumar K; Dostal David E; Boheler Kenneth; Baker Kenneth M; Lakatta Edward G
Differential response of cardiac fibroblasts from young adult and senescent rats to ANG II.
American journal of physiology. Heart and circulatory physiology 2003;284(4):H1454-9.
2003: Fedorova Olga V; Talan Mark I; Agalakova Natalia I; Droy-Lefaix Marie-Therese; Lakatta Edward G; Bagrov Alexei Y
Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension.
Hypertension 2003;41(3):505-11.
2003: Boheler Kenneth R; Volkova Maria; Morrell Christopher; Garg Rahul; Zhu Yi; Margulies Kenneth; Seymour Anne-Marie; Lakatta Edward G
Sex- and age-dependent human transcriptome variability: implications for chronic heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2754-9.
2003: Lakatta Edward G; Maltsev Victor A; Bogdanov Konstantin Y; Stern Michael D; Vinogradova Tatiana M
Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance.
Circulation research 2003;92(3):e45-50.
2003: Lakatta Edward G
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging.
Circulation 2003;107(3):490-7.
2003: Lakatta Edward G; Levy Daniel
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.
Circulation 2003;107(2):346-54.
2003: Lakatta Edward G; Levy Daniel
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.
Circulation 2003;107(1):139-46.
2002: Hees Paul S; Fleg Jerome L; Lakatta Edward G; Shapiro Edward P
Left ventricular remodeling with age in normal men versus women: novel insights using three-dimensional magnetic resonance imaging.
The American journal of cardiology 2002;90(11):1231-6.
2002: Lakatta Edward G; Sollott Steven J
The "heartbreak" of older age.
Molecular interventions 2002;2(7):431-46.
2002: Josephson Ira R; Guia Antonio; Lakatta Edward G; Stern Michael D
Modulation of the conductance of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions.
Biophysical journal 2002;83(5):2587-94.
2002: Josephson Ira R; Guia Antonio; Lakatta Edward G; Stern Michael D
Modulation of the gating of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions.
Biophysical journal 2002;83(5):2575-86.
2002: Correia Luis C L; Lakatta Edward G; O'Connor Frances C; Becker Lewis C; Clulow Jon; Townsend Susan; Gerstenblith Gary; Fleg Jerome L
Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects.
Journal of the American College of Cardiology 2002;40(7):1290-7.
2002: Wang Shi Qiang; Lakatta Edward G; Cheng Heping; Zhou Zeng Quan
Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators.
The Journal of experimental biology 2002;205(Pt 19):2957-62.
2002: Lakatta Edward G; Vinogradova Tatiana M; Bogdanov Konstantin Y
Beta-adrenergic stimulation modulation of heart rate via synchronization of ryanodine receptor Ca2+ release.
Journal of cardiac surgery 2002;17(5):451-61.
2002: Lavoie Catherine; Mercier Jean-Francois; Salahpour Ali; Umapathy Dhiviya; Breit Andreas; Villeneuve Louis-Robert; Zhu Wei-Zhong; Xiao Rui-Ping; Lakatta Edward G; Bouvier Michel; Hébert Terence E
Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.
The Journal of biological chemistry 2002;277(38):35402-10.
2002: Vinogradova Tatiana M; Bogdanov Konstantin Yu; Lakatta Edward G
Novel perspectives on the beating rate of the heart.
Circulation research 2002;91(4):e3.
2002: Anisimov Sergey V; Tarasov Kirill V; Stern Michael D; Lakatta Edward G; Boheler Kenneth R
A quantitative and validated SAGE transcriptome reference for adult mouse heart.
Genomics 2002;80(2):213-22.
2002: Lakatta Edward G; Sollott Steven J
Perspectives on mammalian cardiovascular aging: humans to molecules.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2002;132(4):699-721.
2002: Yang Huang-Tian; Tweedie David; Wang Su; Guia Antonio; Vinogradova Tatiana; Bogdanov Konstantin; Allen Paul D; Stern Michael D; Lakatta Edward G; Boheler Kenneth R
The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9225-30.
2002: Wang Shi-Qiang; Song Long-Sheng; Xu Le; Meissner Gerhard; Lakatta Edward G; Ríos Eduardo; Stern Michael D; Cheng Heping
Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks.
Biophysical journal 2002;83(1):242-51.
2002: Janczewski Andrzej M; Spurgeon Harold A; Lakatta Edward G
Action potential prolongation in cardiac myocytes of old rats is an adaptation to sustain youthful intracellular Ca2+ regulation.
Journal of molecular and cellular cardiology 2002;34(6):641-8.
2002: Fridman Alexander I; Matveev Sergei A; Agalakova Natalia I; Fedorova Olga V; Lakatta Edward G; Bagrov Alexei Y
Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.
Journal of hypertension 2002;20(6):1189-94.
2002: Wang Mingyi; Lakatta Edward G
Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging.
Hypertension 2002;39(4):865-73.
2002: Josephson Ira R; Guia Antonio; Stern Michael D; Lakatta Edward G
Alterations in properties of L-type Ca channels in aging rat heart.
Journal of molecular and cellular cardiology 2002;34(3):297-308.
2002: Fedorova Olga V; Talan Mark I; Agalakova Natalia I; Lakatta Edward G; Bagrov Alexei Y
Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension.
Circulation 2002;105(9):1122-7.
2002: Fedorova Olga V; Dorofeeva Natalia A; Lopatin Denis A; Lakatta Edward G; Bagrov Alexei Y
Phorbol diacetate potentiates na(+)-k(+) ATPase inhibition by a putative endogenous ligand, marinobufagenin.
Hypertension 2002;39(2):298-302.
2002: Song Long-Sheng; Guia António; Muth James N; Rubio Marta; Wang Shi-Qiang; Xiao Rui-Ping; Josephson Ira R; Lakatta Edward G; Schwartz Arnold; Cheng Heping
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Circulation research 2002;90(2):174-81.
2002: Mackey Rachel H; Sutton-Tyrrell Kim; Vaitkevicius Peter V; Sakkinen Pamela A; Lyles Mary F; Spurgeon Harold A; Lakatta Edward G; Kuller Lewis H
Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study.
American journal of hypertension 2002;15(1 Pt 1):16-23.
2002: Lakatta Edward G
Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons.
Heart failure reviews 2002;7(1):29-49.
2002: Lakatta Edward G
Introduction: chronic heart failure in older persons.
Heart failure reviews 2002;7(1):5-8.
2002: Vinogradova Tatiana M; Bogdanov Konstantin Yu; Lakatta Edward G
beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells.
Circulation research 2002;90(1):73-9.
2002: Lakatta Edward G
Cardiovascular ageing in health sets the stage for cardiovascular disease.
Heart, lung & circulation 2002;11(2):76-91.
2001: Scuteri A; Chen C H; Yin F C; Chih-Tai T; Spurgeon H A; Lakatta E G
Functional correlates of central arterial geometric phenotypes.
Hypertension 2001;38(6):1471-5.
2001: Neuss M; Crow M T; Chesley A; Lakatta E G
Apoptosis in cardiac disease--what is it--how does it occur.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2001;15(6):507-23.
2001: Kass D A; Shapiro E P; Kawaguchi M; Capriotti A R; Scuteri A; deGroof R C; Lakatta E G
Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.
Circulation 2001;104(13):1464-70.
2001: Sutton-Tyrrell K; Newman A; Simonsick E M; Havlik R; Pahor M; Lakatta E; Spurgeon H; Vaitkevicius P
Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition.
Hypertension 2001;38(3):429-33.
2001: Fedorova O V; Anderson D E; Lakatta E G; Bagrov A Y
Interaction of NaCl and behavioral stress on endogenous sodium pump ligands in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(1):R352-8.
2001: Bogdanov K Y; Vinogradova T M; Lakatta E G
Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation.
Circulation research 2001;88(12):1254-8.
2001: Anisimov S V; Lakatta E G; Boheler K R
Discovering altered genomic expression patterns in heart: transcriptome determination by serial analysis of gene expression.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2001;3(3):271-81.
2001: Guia A; Stern M D; Lakatta E G; Josephson I R
Ion concentration-dependence of rat cardiac unitary L-type calcium channel conductance.
Biophysical journal 2001;80(6):2742-50.
2001: Sutton-Tyrrell K; Mackey R H; Holubkov R; Vaitkevicius P V; Spurgeon H A; Lakatta E G
Measurement variation of aortic pulse wave velocity in the elderly.
American journal of hypertension 2001;14(5 Pt 1):463-8.
2001: Heldman A W; Cheng L; Jenkins G M; Heller P F; Kim D W; Ware M; Nater C; Hruban R H; Rezai B; Abella B S; Bunge K E; Kinsella J L; Sollott S J; Lakatta E G; Brinker J A; Hunter W L; Froehlich J P
Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis.
Circulation 2001;103(18):2289-95.
2001: Scuteri A; Lakatta E G; Bos A J; Fleg J L
Effect of estrogen and progestin replacement on arterial stiffness indices in postmenopausal women.
Aging (Milan, Italy) 2001;13(2):122-30.
2001: Song L S; Wang S Q; Xiao R P; Spurgeon H; Lakatta E G; Cheng H
beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes.
Circulation research 2001;88(8):794-801.
2001: Wang S Q; Song L S; Lakatta E G; Cheng H
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells.
Nature 2001;410(6828):592-6.
2001: Fedorova O V; Kolodkin N I; Agalakova N I; Lakatta E G; Bagrov A Y
Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats.
Hypertension 2001;37(2 Part 2):462-6.
2001: Vaitkevicius P V; Lane M; Spurgeon H; Ingram D K; Roth G S; Egan J J; Vasan S; Wagle D R; Ulrich P; Brines M; Wuerth J P; Cerami A; Lakatta E G
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1171-5.
2001: Scuteri A; Bos A J; Zonderman A B; Brant L J; Lakatta E G; Fleg J L
Is the apoE4 allele an independent predictor of coronary events?
The American journal of medicine 2001;110(1):28-32.
2001: Havlik R J; Brock D; Lohman K; Haskell W; Snell P; O'Toole M; Ribisl P; Vaitkevicius P; Spurgeon H A; Lakatta E G; Pullen P
High-density lipoprotein cholesterol and vascular stiffness at baseline in the activity counseling trial.
The American journal of cardiology 2001;87(1):104-7, A9.
2001: Lakatta E G; Sollott S J; Pepe S
The old heart: operating on the edge.
Novartis Foundation symposium 2001;235():172-96; discussion 196-201, 217-20.
2000: Fedorova O V; Lakatta E G; Bagrov A Y
Endogenous Na,K pump ligands are differentially regulated during acute NaCl loading of Dahl rats.
Circulation 2000;102(24):3009-14.
2000: Chesley A; Lundberg M S; Asai T; Xiao R P; Ohtani S; Lakatta E G; Crow M T
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase.
Circulation research 2000;87(12):1172-9.
2000: Chen-Izu Y; Xiao R P; Izu L T; Cheng H; Kuschel M; Spurgeon H; Lakatta E G
G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.
Biophysical journal 2000;79(5):2547-56.
2000: Zhou Y Y; Yang D; Zhu W Z; Zhang S J; Wang D J; Rohrer D K; Devic E; Kobilka B K; Lakatta E G; Cheng H; Xiao R P
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice.
Molecular pharmacology 2000;58(5):887-94.
2000: Janczewski A M; Lakatta E G; Stern M D
Voltage-independent changes in L-type Ca(2+) current uncoupled from SR Ca(2+) release in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H2024-31.
2000: Younès A; Pepe S; Barron B A; Spurgeon H A; Lakatta E G; Caffrey J L
Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1989-98.
2000: Li Z; Nater C; Kinsella J; Chrest F; Lakatta E G
Minoxidil inhibits proliferation and migration of cultured vascular smooth muscle cells and neointimal formation after balloon catheter injury.
Journal of cardiovascular pharmacology 2000;36(2):270-6.
2000: Gowdak L H; Poliakova L; Wang X; Kovesdi I; Fishbein K W; Zacheo A; Palumbo R; Straino S; Emanueli C; Marrocco-Trischitta M; Lakatta E G; Anversa P; Spencer R G; Talan M; Capogrossi M C
Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia.
Circulation 2000;102(5):565-71.
2000: Lakatta E G
Cardiovascular aging in health.
Clinics in geriatric medicine 2000;16(3):419-44.
2000: Gowdak L H; Poliakova L; Li Z; Grove R; Lakatta E G; Talan M
Induction of angiogenesis by cationic lipid-mediated VEGF165 gene transfer in the rabbit ischemic hindlimb model.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2000;32(2):343-52.
2000: Zhou Y Y; Wang S Q; Zhu W Z; Chruscinski A; Kobilka B K; Ziman B; Wang S; Lakatta E G; Cheng H; Xiao R P
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H429-36.
2000: Zhang S J; Cheng H; Zhou Y Y; Wang D J; Zhu W; Ziman B; Spurgoen H; Lefkowitz R J; Lakatta E G; Koch W J; Xiao R P
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
2000: Bagrov A Y; Dmitrieva R I; Dorofeeva N A; Fedorova O V; Lopatin D A; Lakatta E G; Droy-Lefaix M T
Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism.
Journal of hypertension 2000;18(2):209-15.
1999: Zhou Y Y; Song L S; Lakatta E G; Xiao R P; Cheng H
Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
The Journal of physiology 1999;521 Pt 2():351-61.
1999: Xiao R P; Cheng H; Zhou Y Y; Kuschel M; Lakatta E G
Recent advances in cardiac beta(2)-adrenergic signal transduction.
Circulation research 1999;85(11):1092-100.
1999: Nussbacher A; Gerstenblith G; O'Connor F C; Becker L C; Kass D A; Schulman S P; Fleg J L; Lakatta E G
Hemodynamic effects of unloading the old heart.
The American journal of physiology 1999;277(5 Pt 2):H1863-71.
1999: Zhou Y Y; Cheng H; Song L S; Wang D; Lakatta E G; Xiao R P
Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes.
Molecular pharmacology 1999;56(3):485-93.
1999: Srivastava R K; Sollott S J; Khan L; Hansford R; Lakatta E G; Longo D L
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis.
Molecular and cellular biology 1999;19(8):5659-74.
1999: Kuschel M; Zhou Y Y; Cheng H; Zhang S J; Chen Y; Lakatta E G; Xiao R P
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
The Journal of biological chemistry 1999;274(31):22048-52.
1999: Muth J N; Yamaguchi H; Mikala G; Grupp I L; Lewis W; Cheng H; Song L S; Lakatta E G; Varadi G; Schwartz A
Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction.
The Journal of biological chemistry 1999;274(31):21503-6.
1999: Vila-Petroff M G; Younes A; Egan J; Lakatta E G; Sollott S J
Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes.
Circulation research 1999;84(9):1020-31.
1999: Lakatta E G
Cardiovascular aging research: the next horizons.
Journal of the American Geriatrics Society 1999;47(5):613-25.
1999: Kuschel M; Zhou Y Y; Spurgeon H A; Bartel S; Karczewski P; Zhang S J; Krause E G; Lakatta E G; Xiao R P
beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart.
Circulation 1999;99(18):2458-65.
1999: Cheng H; Song L S; Shirokova N; González A; Lakatta E G; Ríos E; Stern M D
Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method.
Biophysical journal 1999;76(2):606-17.
1999: Long X; Boluyt M O; O'Neill L; Zheng J S; Wu G; Nitta Y K; Crow M T; Lakatta E G
Myocardial retinoid X receptor, thyroid hormone receptor, and myosin heavy chain gene expression in the rat during adult aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 1999;54(1):B23-7.
1999: Li Z; Froehlich J; Galis Z S; Lakatta E G
Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats.
Hypertension 1999;33(1):116-23.
1999: Xiao R P; Avdonin P; Zhou Y Y; Cheng H; Akhter S A; Eschenhagen T; Lefkowitz R J; Koch W J; Lakatta E G
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Circulation research 1999;84(1):43-52.
1999: Pepe S; Tsuchiya N; Lakatta E G; Hansford R G
PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH.
The American journal of physiology 1999;276(1 Pt 2):H149-58.
1998: Sham J S; Song L S; Chen Y; Deng L H; Stern M D; Lakatta E G; Cheng H
Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):15096-101.
1998: Mebazaa A; Wetzel R C; Dodd-o J M; Redmond E M; Shah A M; Maeda K; Maistre G; Lakatta E G; Robotham J L
Potential paracrine role of the pericardium in the regulation of cardiac function.
Cardiovascular research 1998;40(2):332-42.
1998: Song L S; Sham J S; Stern M D; Lakatta E G; Cheng H
Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes.
The Journal of physiology 1998;512 ( Pt 3)():677-91.
1998: Nagai Y; Metter E J; Earley C J; Kemper M K; Becker L C; Lakatta E G; Fleg J L
Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia.
Circulation 1998;98(15):1504-9.
1998: Zhou Y Y; Lakatta E G; Xiao R P
Age-associated alterations in calcium current and its modulation in cardiac myocytes.
Drugs & aging 1998;13(2):159-71.
1998: Chen C H; Ting C T; Lin S J; Hsu T L; Ho S J; Chou P; Chang M S; O'Connor F; Spurgeon H; Lakatta E; Yin F C
Which arterial and cardiac parameters best predict left ventricular mass?
Circulation 1998;98(5):422-8.
1998: Shah A M; Sollott S J; Lakatta E G
Physio-pharmacological evaluation of myocardial performance: an integrative approach.
Cardiovascular research 1998;39(1):148-54.
1998: Gambassi G; Spurgeon H A; Ziman B D; Lakatta E G; Capogrossi M C
Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes.
The American journal of physiology 1998;274(4 Pt 2):H1152-62.
1998: Zheng J S; O'Neill L; Long X; Webb T E; Barnard E A; Lakatta E G; Boluyt M O
Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts.
Cardiovascular research 1998;37(3):718-28.
1998: Long X; Crow M T; Sollott S J; O'Neill L; Menees D S; de Lourdes Hipolito M; Boluyt M O; Asai T; Lakatta E G
Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes.
The Journal of clinical investigation 1998;101(6):1453-61.
1998: Xiao R P; Tomhave E D; Wang D J; Ji X; Boluyt M O; Cheng H; Lakatta E G; Koch W J
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation 1998;101(6):1273-82.
1998: Bogdanov K Y; Spurgeon H A; Vinogradova T M; Lakatta E G
Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids.
The American journal of physiology 1998;274(2 Pt 2):H571-9.
1998: Jenkins G M; Crow M T; Bilato C; Gluzband Y; Ryu W S; Li Z; Stetler-Stevenson W; Nater C; Froehlich J P; Lakatta E G; Cheng L
Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries.
Circulation 1998;97(1):82-90.
1997: Song L S; Stern M D; Lakatta E G; Cheng H
Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes.
The Journal of physiology 1997;505 ( Pt 3)():665-75.
1997: Brooks W W; Bing O H; Conrad C H; O'Neill L; Crow M T; Lakatta E G; Dostal D E; Baker K M; Boluyt M O
Captopril modifies gene expression in hypertrophied and failing hearts of aged spontaneously hypertensive rats.
Hypertension 1997;30(6):1362-8.
1997: Zhou Y Y; Cheng H; Bogdanov K Y; Hohl C; Altschuld R; Lakatta E G; Xiao R P
Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling.
The American journal of physiology 1997;273(3 Pt 2):H1611-8.
1997: Boluyt M O; Zheng J S; Younes A; Long X; O'Neill L; Silverman H; Lakatta E G; Crow M T
Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase.
Circulation research 1997;81(2):176-86.
1997: Long X; Boluyt M O; Hipolito M L; Lundberg M S; Zheng J S; O'Neill L; Cirielli C; Lakatta E G; Crow M T
p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.
The Journal of clinical investigation 1997;99(11):2635-43.
1997: Li Z; Bing O H; Long X; Robinson K G; Lakatta E G
Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat.
The American journal of physiology 1997;272(5 Pt 2):H2313-9.
1997: Shah A M; Mebazaa A; Yang Z K; Cuda G; Lankford E B; Pepper C B; Sollott S J; Sellers J R; Robotham J L; Lakatta E G
Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand?
Circulation research 1997;80(5):688-98.
1997: Xiao R P; Valdivia H H; Bogdanov K; Valdivia C; Lakatta E G; Cheng H
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.
The Journal of physiology 1997;500 ( Pt 2)():343-54.
1997: Pepe S; Xiao R P; Hohl C; Altschuld R; Lakatta E G
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
Circulation 1997;95(8):2122-9.
1997: Dodd-o J M; Zheng G; Silverman H S; Lakatta E G; Ziegelstein R C
Endothelium-independent relaxation of aortic rings by the nitric oxide synthase inhibitor diphenyleneiodonium.
British journal of pharmacology 1997;120(5):857-64.
1997: Li Z; Cheng H; Lederer W J; Froehlich J; Lakatta E G
Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants.
Experimental and molecular pathology 1997;64(1):1-11.
1997: Xiao R P; Pepe S; Spurgeon H A; Capogrossi M C; Lakatta E G
Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.
The American journal of physiology 1997;272(2 Pt 2):H797-805.
1997: Korzick D H; Xiao R P; Ziman B D; Koch W J; Lefkowitz R J; Lakatta E G
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
The American journal of physiology 1997;272(1 Pt 2):H590-6.
1997: Miyashita Y; Sollott S J; Cheng L; Kinsella J L; Koh E; Lakatta E G; Froehlich J P
Redistribution of intracellular Ca2+ stores after beta-adrenergic stimulation of rat tail artery SMC.
The American journal of physiology 1997;272(1 Pt 2):H244-55.
1996: Sollott S J; Ziman B D; Warshaw D M; Spurgeon H A; Lakatta E G
Actomyosin interaction modulates resting length of unstimulated cardiac ventricular cells.
The American journal of physiology 1996;271(3 Pt 2):H896-905.
1996: Cheng H; Lederer M R; Xiao R P; Gómez A M; Zhou Y Y; Ziman B; Spurgeon H; Lakatta E G; Lederer W J
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
Cell calcium 1996;20(2):129-40.
1996: Schulman S P; Fleg J L; Goldberg A P; Busby-Whitehead J; Hagberg J M; O'Connor F C; Gerstenblith G; Becker L C; Katzel L I; Lakatta L E; Lakatta E G
Continuum of cardiovascular performance across a broad range of fitness levels in healthy older men.
Circulation 1996;94(3):359-67.
1996: Zheng J S; Boluyt M O; Long X; O'Neill L; Lakatta E G; Crow M T
Extracellular ATP inhibits adrenergic agonist-induced hypertrophy of neonatal cardiac myocytes.
Circulation research 1996;78(4):525-35.
1996: Li Z; Li L; Zielke H R; Cheng L; Xiao R; Crow M T; Stetler-Stevenson W G; Froehlich J; Lakatta E G
Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions.
The American journal of pathology 1996;148(1):121-8.
1995: Bogdanov K Y; Ziman B D; Spurgeon H A; Lakatta E G
L- and T-type calcium currents differ in finch and rat ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 1995;27(12):2581-93.
1995: Boluyt M O; Bing O H; Lakatta E G
The ageing spontaneously hypertensive rat as a model of the transition from stable compensated hypertrophy to heart failure.
European heart journal 1995;16 Suppl N():19-30.
1995: Corda S; Spurgeon H A; Lakatta E G; Capogrossi M C; Ziegelstein R C
Endoplasmic reticulum Ca2+ depletion unmasks a caffeine-induced Ca2+ influx in human aortic endothelial cells.
Circulation research 1995;77(5):927-35.
1995: Hano O; Bogdanov K Y; Sakai M; Danziger R G; Spurgeon H A; Lakatta E G
Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging.
The American journal of physiology 1995;269(5 Pt 2):H1607-12.
1995: Bilato C; Pauly R R; Melillo G; Monticone R; Gorelick-Feldman D; Gluzband Y A; Sollott S J; Ziman B; Lakatta E G; Crow M T
Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.
The Journal of clinical investigation 1995;96(4):1905-15.
1995: Younes A; Boluyt M O; O'Neill L; Meredith A L; Crow M T; Lakatta E G
Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy.
The American journal of physiology 1995;269(3 Pt 2):H1003-8.
1995: Boluyt M O; Long X; Eschenhagen T; Mende U; Schmitz W; Crow M T; Lakatta E G
Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart.
The American journal of physiology 1995;269(2 Pt 2):H638-47.
1995: Shah A M; Silverman H S; Griffiths E J; Spurgeon H A; Lakatta E G
cGMP prevents delayed relaxation at reoxygenation after brief hypoxia in isolated cardiac myocytes.
The American journal of physiology 1995;268(6 Pt 2):H2396-204.
1995: Fleg J L; Shapiro E P; O'Connor F; Taube J; Goldberg A P; Lakatta E G
Left ventricular diastolic filling performance in older male athletes.
JAMA : the journal of the American Medical Association 1995;273(17):1371-5.
1995: Sollott S J; Cheng L; Pauly R R; Jenkins G M; Monticone R E; Kuzuya M; Froehlich J P; Crow M T; Lakatta E G; Rowinsky E K
Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat.
The Journal of clinical investigation 1995;95(4):1869-76.
1995: Fleg J L; O'Connor F; Gerstenblith G; Becker L C; Clulow J; Schulman S P; Lakatta E G
Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):890-900.
1995: Xiao R P; Ji X; Lakatta E G
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
Molecular pharmacology 1995;47(2):322-9.
1995: Janczewski A M; Spurgeon H A; Stern M D; Lakatta E G
Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells.
The American journal of physiology 1995;268(2 Pt 2):H916-20.
1995: Pauly R R; Bilato C; Sollott S J; Monticone R; Kelly P T; Lakatta E G; Crow M T
Role of calcium/calmodulin-dependent protein kinase II in the regulation of vascular smooth muscle cell migration.
Circulation 1995;91(4):1107-15.
1994: Katzel L I; Sorkin K D; Colman E; Goldberg A P; Busby-Whitehead M J; Lakatta L E; Becker L C; Lakatta E G; Fleg J L
Risk factors for exercise-induced silent myocardial ischemia in healthy volunteers.
The American journal of cardiology 1994;74(9):869-74.
1994: Xiao R P; Spurgeon H A; O'Connor F; Lakatta E G
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
The Journal of clinical investigation 1994;94(5):2051-9.
1994: Fleg J L; Schulman S; O'Connor F; Becker L C; Gerstenblith G; Clulow J F; Renlund D G; Lakatta E G
Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.
Circulation 1994;90(5):2333-41.
1994: Sollott S J; Lakatta E G
Novel method to alter length and load in isolated mammalian cardiac myocytes.
The American journal of physiology 1994;267(4 Pt 2):H1619-29.
1994: Ziegelstein R C; Cheng L; Aversano T; Ouyang P; Lakatta E G; Silverman H S
Increase in rat aortic endothelial free calcium mediated by metabolically sensitive calcium release from endoplasmic reticulum.
Cardiovascular research 1994;28(9):1433-9.
1994: Xiao R P; Cheng H; Lederer W J; Suzuki T; Lakatta E G
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9659-63.
1994: Fleg J L; Schulman S P; O'Connor F C; Gerstenblith G; Becker L C; Fortney S; Goldberg A P; Lakatta E G
Cardiovascular responses to exhaustive upright cycle exercise in highly trained older men.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;77(3):1500-6.
1994: Pepe S; Bogdanov K; Hallaq H; Spurgeon H; Leaf A; Lakatta E
Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8832-6.
1994: O'Connor F; Fleg J L; Gerstenblith G; Becker L C; Goldberg A P; Hagberg J M; Lakatta L; Lakatta E G; Schulman S P
Effect of body fat on exercise hemodynamics in sedentary older men.
Aging (Milan, Italy) 1994;6(4):257-65.
1994: Lakatta E G
Cardiovascular reserve capacity in healthy older humans.
Aging (Milan, Italy) 1994;6(4):213-23.
1994: Xiao R P; Hohl C; Altschuld R; Jones L; Livingston B; Ziman B; Tantini B; Lakatta E G
Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.
The Journal of biological chemistry 1994;269(29):19151-6.
1994: Haigney M C; Lakatta E G; Stern M D; Silverman H S
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Circulation 1994;90(1):391-9.
1994: Pauly R R; Passaniti A; Bilato C; Monticone R; Cheng L; Papadopoulos N; Gluzband Y A; Smith L; Weinstein C; Lakatta E G
Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation.
Circulation research 1994;75(1):41-54.
1994: Boluyt M O; O'Neill L; Meredith A L; Bing O H; Brooks W W; Conrad C H; Crow M T; Lakatta E G
Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.
Circulation research 1994;75(1):23-32.
1994: Shah A M; Mebazaa A; Wetzel R C; Lakatta E G
Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells.
Circulation 1994;89(6):2492-7.
1994: Zheng J S; Boluyt M O; O'Neill L; Crow M T; Lakatta E G
Extracellular ATP induces immediate-early gene expression but not cellular hypertrophy in neonatal cardiac myocytes.
Circulation research 1994;74(6):1034-41.
1994: Caffrey J L; Boluyt M O; Younes A; Barron B A; O'Neill L; Crow M T; Lakatta E G
Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat.
Journal of molecular and cellular cardiology 1994;26(6):701-11.
1994: Hano O; Thompson-Gorman S L; Zweier J L; Lakatta E G
Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion.
The American journal of physiology 1994;266(6 Pt 2):H2174-81.
1994: Shah A M; Spurgeon H A; Sollott S J; Talo A; Lakatta E G
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Circulation research 1994;74(5):970-8.
1994: Silverman H S; Di Lisa F; Hui R C; Miyata H; Sollott S J; Hanford R G; Lakatta E G; Stern M D
Regulation of intracellular free Mg2+ and contraction in single adult mammalian cardiac myocytes.
The American journal of physiology 1994;266(1 Pt 1):C222-33.
1994: Ziegelstein R C; Spurgeon H A; Pili R; Passaniti A; Cheng L; Corda S; Lakatta E G; Capogrossi M C
A functional ryanodine-sensitive intracellular Ca2+ store is present in vascular endothelial cells.
Circulation research 1994;74(1):151-6.
1993: Solaro R J; Gambassi G; Warshaw D M; Keller M R; Spurgeon H A; Beier N; Lakatta E G
Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments.
Circulation research 1993;73(6):981-90.
1993: Mebazaa A; Mayoux E; Maeda K; Martin L D; Lakatta E G; Robotham J L; Shah A M
Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin.
The American journal of physiology 1993;265(5 Pt 2):H1841-6.
1993: Janczewski A M; Lakatta E G
Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes.
The Journal of physiology 1993;471():343-63.
1993: Vaitkevicius P V; Fleg J L; Engel J H; O'Connor F C; Wright J G; Lakatta L E; Yin F C; Lakatta E G
Effects of age and aerobic capacity on arterial stiffness in healthy adults.
Circulation 1993;88(4 Pt 1):1456-62.
1993: Ziegelstein R C; Cheng L; Blank P S; Spurgeon H A; Lakatta E G; Hansford R G; Capogrossi M C
Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification.
The American journal of physiology 1993;265(4 Pt 2):H1424-33.
1993: Gambassi G; Hansford R G; Sollott S J; Hogue B A; Lakatta E G; Capogrossi M C
Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium.
The Journal of general physiology 1993;102(3):575-97.
1993: duBell W H; Lewartowski B; Spurgeon H A; Silverman H S; Lakatta E G
Repletion of sarcoplasmic reticulum Ca after ryanodine in rat ventricular myocytes.
The American journal of physiology 1993;265(2 Pt 2):H604-15.
1993: Janczewski A M; Lakatta E G
Thapsigargin inhibits Ca2+ uptake, and Ca2+ depletes sarcoplasmic reticulum in intact cardiac myocytes.
The American journal of physiology 1993;265(2 Pt 2):H517-22.
1993: Lakatta E G; Guarnieri T
Spontaneous myocardial calcium oscillations: are they linked to ventricular fibrillation?
Journal of cardiovascular electrophysiology 1993;4(4):473-89.
1993: Fleg J L; Schulman S P; Gerstenblith G; Becker L C; O'Connor F C; Lakatta E G
Additive effects of age and silent myocardial ischemia on the left ventricular response to upright cycle exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(2):499-504.
1993: Xiao R P; Lakatta E G
Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.
Circulation research 1993;73(2):286-300.
1993: Boluyt M O; Younes A; Caffrey J L; O'Neill L; Barron B A; Crow M T; Lakatta E G
Age-associated increase in rat cardiac opioid production.
The American journal of physiology 1993;265(1 Pt 2):H212-8.
1993: Xiao R P; Spurgeon H A; Capogrossi M C; Lakatta E G
Stimulation of opioid receptors on cardiac ventricular myocytes reduces L type Ca2+ channel current.
Journal of molecular and cellular cardiology 1993;25(6):661-6.
1993: Lakatta E G
Cardiovascular regulatory mechanisms in advanced age.
Physiological reviews 1993;73(2):413-67.
1993: Chrest F J; Pauly R R; Monticone R; Lakatta E G; Adler W H
TGF beta-1 receptor expression and cell cycle analysis of vascular smooth muscle cells from young and aged rats.
Annals of the New York Academy of Sciences 1993;677():396-9.
1993: Gambassi G; Capogrossi M C; Klockow M; Lakatta E G
Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes.
The American journal of physiology 1993;264(3 Pt 2):H728-38.
1993: Lakatta E G
Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans.
Circulation 1993;87(2):631-6.
1993: Lakatta E G
Myocardial adaptations in advanced age.
Basic research in cardiology 1993;88 Suppl 2():125-33.
1992: Fortney S; Tankersley C; Lightfoot J T; Drinkwater D; Clulow J; Gerstenblith G; O'Connor F; Becker L; Lakatta E; Fleg J
Cardiovascular responses to lower body negative pressure in trained and untrained older men.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(6):2693-700.
1992: Lakatta E G
Interaction between nutrition and aging: a summary of effects on the cardiovascular system.
Nutrition reviews 1992;50(12):419-20.
1992: Schulman S P; Lakatta E G; Fleg J L; Lakatta L; Becker L C; Gerstenblith G
Age-related decline in left ventricular filling at rest and exercise.
The American journal of physiology 1992;263(6 Pt 2):H1932-8.
1992: Xiao R P; Lakatta E G
Deterioration of beta-adrenergic modulation of cardiovascular function with aging.
Annals of the New York Academy of Sciences 1992;673():293-310.
1992: Pauly R R; Passaniti A; Crow M; Kinsella J L; Papadopoulos N; Monticone R; Lakatta E G; Martin G R
Experimental models that mimic the differentiation and dedifferentiation of vascular cells.
Circulation 1992;86(6 Suppl):III68-73.
1992: Gambassi G; Spurgeon H A; Lakatta E G; Blank P S; Capogrossi M C
Different effects of alpha- and beta-adrenergic stimulation on cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes.
Circulation research 1992;71(4):870-82.
1992: Miyata H; Lakatta E G; Stern M D; Silverman H S
Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.
Circulation research 1992;71(3):605-13.
1992: Haigney M C; Miyata H; Lakatta E G; Stern M D; Silverman H S
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Circulation research 1992;71(3):547-57.
1992: Blank P S; Silverman H S; Chung O Y; Hogue B A; Stern M D; Hansford R G; Lakatta E G; Capogrossi M C
Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphthorhodafluor-1.
The American journal of physiology 1992;263(1 Pt 2):H276-84.
1992: Sollott S J; Ziman B D; Lakatta E G
Novel technique to load indo-1 free acid into single adult cardiac myocytes to assess cytosolic Ca2+.
The American journal of physiology 1992;262(6 Pt 2):H1941-9.
1992: Ventura C; Miller R; Wolf H P; Beier N; Jonas R; Klockow M; Lues I; Hano O; Spurgeon H A; Lakatta E G
Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.
Circulation research 1992;70(6):1081-90.
1992: Ziegelstein R C; Zweier J L; Mellits E D; Younes A; Lakatta E G; Stern M D; Silverman H S
Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.
Circulation research 1992;70(4):804-11.
1992: Lakatta E G
Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart.
Cardiovascular research 1992;26(3):193-214.
1992: Spurgeon H A; duBell W H; Stern M D; Sollott S J; Ziman B D; Silverman H S; Capogrossi M C; Talo A; Lakatta E G
Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation.
The Journal of physiology 1992;447():83-102.
1992: Sakai M; Danziger R S; Xiao R P; Spurgeon H A; Lakatta E G
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence.
The American journal of physiology 1992;262(1 Pt 2):H184-9.
1992: Ventura C; Spurgeon H; Lakatta E G; Guarnieri C; Capogrossi M C
Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons.
Circulation research 1992;70(1):66-81.
1992: Kasper E; Ventura C; Ziman B D; Lakatta E G; Weisman H; Capogrossi M C
Effect of U-50,488H on the contractile response of cardiomyopathic hamster ventricular myocytes.
Life sciences 1992;50(26):2029-35.
1992: Lakatta E G; Talo A; Capogrossi M C; Spurgeon H A; Stern M D
Spontaneous sarcoplasmic reticulum Ca2+ release leads to heterogeneity of contractile and electrical properties of the heart.
Basic research in cardiology 1992;87 Suppl 2():93-104.
1991: Hano O; Silverman H S; Blank P S; Mellits E D; Baumgardner R; Lakatta E G; Stern M D
Nicardipine prevents calcium loading and "oxygen paradox" in anoxic single rat myocytes by a mechanism independent of calcium channel blockade.
Circulation research 1991;69(6):1500-5.
1991: Ventura C; Capogrossi M C; Spurgeon H A; Lakatta E G
Kappa-opioid peptide receptor stimulation increases cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes.
The American journal of physiology 1991;261(5 Pt 2):H1671-4.
1991: Miyata H; Silverman H S; Sollott S J; Lakatta E G; Stern M D; Hansford R G
Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes.
The American journal of physiology 1991;261(4 Pt 2):H1123-34.
1991: Ventura C; Guarnieri C; Stefanelli C; Cirielli C; Lakatta E G; Capogrossi M C
Comparison between alpha-adrenergic- and K-opioidergic-mediated inositol (1,4,5)P3/inositol (1,3,4,5) P4 formation in adult cultured rat ventricular cardiomyocytes.
Biochemical and biophysical research communications 1991;179(2):972-8.
1991: Capogrossi M C; Kachadorian W A; Gambassi G; Spurgeon H A; Lakatta E G
Ca2+ dependence of alpha-adrenergic effects on the contractile properties and Ca2+ homeostasis of cardiac myocytes.
Circulation research 1991;69(2):540-50.
1991: Silverman H S; Ninomiya M; Blank P S; Hano O; Miyata H; Spurgeon H A; Lakatta E G; Stern M D
A cellular mechanism for impaired posthypoxic relaxation in isolated cardiac myocytes. Altered myofilament relaxation kinetics at reoxygenation.
Circulation research 1991;69(1):196-208.
1991: Hano O; Lakatta E G
Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses.
Circulation research 1991;69(1):123-33.
1991: Danziger R S; Sakai M; Capogrossi M C; Spurgeon H A; Hansford R G; Lakatta E G
Ethanol acutely and reversibly suppresses excitation-contraction coupling in cardiac myocytes.
Circulation research 1991;68(6):1660-8.
1991: duBell W H; Boyett M R; Spurgeon H A; Talo A; Stern M D; Lakatta E G
The cytosolic calcium transient modulates the action potential of rat ventricular myocytes.
The Journal of physiology 1991;436():347-69.
1991: Schulman S P; Lakatta E G; Weiss R G; Wolff M R; Hano O; Gerstenblith G
Contractile, metabolic and electrophysiologic effects of ethanol in the isolated rat heart.
Journal of molecular and cellular cardiology 1991;23(4):417-26.
1991: O'Neill L; Holbrook N J; Fargnoli J; Lakatta E G
Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes.
Cardioscience 1991;2(1):1-5.
1991: Ferroni C; Hano O; Ventura C; Lakatta E G; Klockow M; Spurgeon H; Capogrossi M C
A novel positive inotropic substance enhances contractility without increasing the Ca2+ transient in rat myocardium.
Journal of molecular and cellular cardiology 1991;23(3):325-31.
1991: Kaku T; Lakatta E; Filburn C
Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes.
The American journal of physiology 1991;260(3 Pt 1):C635-42.
1991: Josephson R A; Silverman H S; Lakatta E G; Stern M D; Zweier J L
Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes.
The Journal of biological chemistry 1991;266(4):2354-61.
1991: Gambassi G; Lakatta E G; Capogrossi M C
[Alpha but not beta-adrenergic stimulation has a positive inotropic effect associated with alkalinization of intracellular pH]
Cardiologia (Rome, Italy) 1991;36(1):47-58.
1990: Talo A; Stern M D; Spurgeon H A; Isenberg G; Lakatta E G
Sustained subthreshold-for-twitch depolarization in rat single ventricular myocytes causes sustained calcium channel activation and sarcoplasmic reticulum calcium release.
The Journal of general physiology 1990;96(5):1085-103.
1990: Lakatta E G
Similar myocardial effects of aging and hypertension.
European heart journal 1990;11 Suppl G():29-38.
1990: Lewartowski B; Hansford R G; Langer G A; Lakatta E G
Contraction and sarcoplasmic reticulum Ca2+ content in single myocytes of guinea pig heart: effect of ryanodine.
The American journal of physiology 1990;259(4 Pt 2):H1222-9.
1990: Guarnieri T; Lakatta E G
Mechanism of myocardial contractile depression by clinical concentrations of ethanol. A study in ferret papillary muscles.
The Journal of clinical investigation 1990;85(5):1462-7.
1990: Lakatta E G
Changes in cardiovascular function with aging.
European heart journal 1990;11 Suppl C():22-9.
1990: Capogrossi M C; Kaku T; Filburn C R; Pelto D J; Hansford R G; Spurgeon H A; Lakatta E G
Phorbol ester and dioctanoylglycerol stimulate membrane association of protein kinase C and have a negative inotropic effect mediated by changes in cytosolic Ca2+ in adult rat cardiac myocytes.
Circulation research 1990;66(4):1143-55.
1990: Weiss R G; Lakatta E G; Gerstenblith G
Effects of amiloride on metabolism and contractility during reoxygenation in perfused rat hearts.
Circulation research 1990;66(4):1012-22.
1990: Weiss R G; Gerstenblith G; Lakatta E G
Calcium oscillations index the extent of calcium loading and predict functional recovery during reperfusion in rat myocardium.
The Journal of clinical investigation 1990;85(3):757-65.
1990: Josephson R A; Spurgeon H A; Lakatta E G
The hyperthyroid heart. An analysis of systolic and diastolic properties in single rat ventricular myocytes.
Circulation research 1990;66(3):773-81.
1990: Spurgeon H A; Stern M D; Baartz G; Raffaeli S; Hansford R G; Talo A; Lakatta E G; Capogrossi M C
Simultaneous measurement of Ca2+, contraction, and potential in cardiac myocytes.
The American journal of physiology 1990;258(2 Pt 2):H574-86.
1990: Renlund D G; Gerstenblith G; Fleg J L; Becker L C; Lakatta E G
Interaction between left ventricular end-diastolic and end-systolic volumes in normal humans.
The American journal of physiology 1990;258(2 Pt 2):H473-81.
1990: Fleg J L; Gerstenblith G; Zonderman A B; Becker L C; Weisfeldt M L; Costa P T; Lakatta E G
Prevalence and prognostic significance of exercise-induced silent myocardial ischemia detected by thallium scintigraphy and electrocardiography in asymptomatic volunteers.
Circulation 1990;81(2):428-36.
1990: Danziger R S; Sakai M; Lakatta E G; Hansford R G
Interactive alpha- and beta-adrenergic actions of norepinephrine in rat cardiac myocytes.
Journal of molecular and cellular cardiology 1990;22(1):111-23.
1989: Sakai M; Danziger R S; Staddon J M; Lakatta E G; Hansford R G
Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes.
Journal of molecular and cellular cardiology 1989;21(12):1327-36.
1989: Stern M D; Spurgeon H A; Hansford R; Lakatta E G; Capogrossi M C
Optimum spectral windows to minimize quantum noise of ratiometric intracellular fluorescent probes.
Cell calcium 1989;10(8):527-34.
1989: Lakatta E G
Mechanisms of hypertension in the elderly.
Journal of the American Geriatrics Society 1989;37(8):780-90.
1989: Stern M D; Weisman H F; Renlund D G; Gerstenblith G; Hano O; Blank P S; Lakatta E G
Laser backscatter studies of intracellular Ca2+ oscillations in isolated hearts.
The American journal of physiology 1989;257(2 Pt 2):H665-73.
1989: Fraticelli A; Josephson R; Danziger R; Lakatta E; Spurgeon H
Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence.
The American journal of physiology 1989;257(1 Pt 2):H259-65.
1988: Stern M D; Capogrossi M C; Lakatta E G
Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences.
Cell calcium 1988;9(5-6):247-56.
1988: Kort A A; Lakatta E G
Spontaneous sarcoplasmic reticulum calcium release in rat and rabbit cardiac muscle: relation to transient and rested-state twitch tension.
Circulation research 1988;63(5):969-79.
1988: Kort A A; Lakatta E G
Bimodal effect of stimulation on light fluctuation transients monitoring spontaneous sarcoplasmic reticulum calcium release in rat cardiac muscle.
Circulation research 1988;63(5):960-8.
1988: McIvor M E; Orchard C H; Lakatta E G
Dissociation of changes in apparent myofibrillar Ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle.
The Journal of general physiology 1988;92(4):509-29.
1988: Stern M D; Silverman H S; Houser S R; Josephson R A; Capogrossi M C; Nichols C G; Lederer W J; Lakatta E G
Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6954-8.
1988: Fleg J L; Lakatta E G
Role of muscle loss in the age-associated reduction in VO2 max.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(3):1147-51.
1988: Walford G D; Spurgeon H A; Lakatta E G
Diminished cardiac hypertrophy and muscle performance in older compared with younger adult rats with chronic atrioventricular block.
Circulation research 1988;63(3):502-11.
1988: Danziger R S; Raffaeli S; Moreno-Sanchez R; Sakai M; Capogrossi M C; Spurgeon H A; Hansford R G; Lakatta E G
Extracellular ATP has a potent effect to enhance cytosolic calcium and contractility in single ventricular myocytes.
Cell calcium 1988;9(4):193-9.
1988: Capogrossi M C; Stern M D; Spurgeon H A; Lakatta E G
Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium.
The Journal of general physiology 1988;91(1):133-55.
1987: Lakatta E G
Catecholamines and cardiovascular function in aging.
Endocrinology and metabolism clinics of North America 1987;16(4):877-91.
1987: Renlund D G; Lakatta E G; Fleg J L; Becker L C; Clulow J F; Weisfeldt M L; Gerstenblith G
Prolonged decrease in cardiac volumes after maximal upright bicycle exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(5):1947-55.
1987: Capogrossi M C; Houser S R; Bahinski A; Lakatta E G
Synchronous occurrence of spontaneous localized calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential.
Circulation research 1987;61(4):498-503.
1987: Hansford R G; Lakatta E G
Ryanodine releases calcium from sarcoplasmic reticulum in calcium-tolerant rat cardiac myocytes.
The Journal of physiology 1987;390():453-67.
1987: Orchard C H; Houser S R; Kort A A; Bahinski A; Capogrossi M C; Lakatta E G
Acidosis facilitates spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium.
The Journal of general physiology 1987;90(1):145-65.
1986: Capogrossi M C; Kort A A; Spurgeon H A; Lakatta E G
Single adult rabbit and rat cardiac myocytes retain the Ca2+- and species-dependent systolic and diastolic contractile properties of intact muscle.
The Journal of general physiology 1986;88(5):589-613.
1985: Lakatta E G; Capogrossi M C; Kort A A; Stern M D
Spontaneous myocardial calcium oscillations: overview with emphasis on ryanodine and caffeine.
Federation proceedings 1985;44(15):2977-83.
1985: Kort A A; Capogrossi M C; Lakatta E G
Frequency, amplitude, and propagation velocity of spontaneous Ca++-dependent contractile waves in intact adult rat cardiac muscle and isolated myocytes.
Circulation research 1985;57(6):844-55.
1985: Kort A A; Lakatta E G; Marban E; Stern M D; Wier W G
Fluctuations in intracellular calcium concentration and their effect on tonic tension in canine cardiac Purkinje fibres.
The Journal of physiology 1985;367():291-308.
1983: Wier W G; Kort A A; Stern M D; Lakatta E G; Marban E
Cellular calcium fluctuations in mammalian heart: direct evidence from noise analysis of aequorin signals in Purkinje fibers.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7367-71.
1983: Stern M D; Kort A A; Bhatnagar G M; Lakatta E G
Scattered-light intensity fluctuations in diastolic rat cardiac muscle caused by spontaneous Ca++-dependent cellular mechanical oscillations.
The Journal of general physiology 1983;82(1):119-53.

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