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Edward Lakatta

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Shih-Hsien Sung; Chih-Tai Ting; Kang-Ling Wang; Frank C P Yin; Wen-Chung Yu; Hao-Min Cheng; Pesus Chou; Shao-Yuan Chuang; Edward G Lakatta; Chen-Huan Chen
White coat hypertension is more risky than prehypertension: important role of arterial wave reflections.
Ismayil Ahmet; Michael Brines; Anthony Cerami; Edward G Lakatta; Hyun-Jin Tae; Mark I Talan
Chronic administration of small nonerythropoietic Peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy.
Victor A Maltsev; Edward G Lakatta
Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.

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2013: Shih-Hsien Sung; Chih-Tai Ting; Kang-Ling Wang; Frank C P Yin; Wen-Chung Yu; Hao-Min Cheng; Pesus Chou; Shao-Yuan Chuang; Edward G Lakatta; Chen-Huan Chen
White coat hypertension is more risky than prehypertension: important role of arterial wave reflections.
Hypertension 2013;61(6):1346-53.
2013: Ismayil Ahmet; Michael Brines; Anthony Cerami; Edward G Lakatta; Hyun-Jin Tae; Mark I Talan
Chronic administration of small nonerythropoietic Peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy.
The Journal of pharmacology and experimental therapeutics 2013;345(3):446-56.
2013: Victor A Maltsev; Edward G Lakatta
Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.
Journal of molecular and cellular cardiology 2013;59():181-95.
2013: Edward G Lakatta; Yael Yaniv; Victor A Maltsev
Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".
American journal of physiology. Cell physiology 2013;304(10):C941-4.
2013: Oliver Monfredi; Victor A Maltsev; Edward G Lakatta
Modern concepts concerning the origin of the heartbeat.
Physiology (Bethesda, Md.) 2013;28(2):74-92.
2013: Syevda G Sirenko; Dongmei Yang; Edward G Lakatta; Yue Li; Yevgeniya O Lukyanenko; Alexey E Lyashkov; Tatiana M Vinogradova
Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells.
Science signaling 2013;6(260):ra6.
2013: Yael Yaniv; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta
Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics.
PloS one 2013;8(2):e57079.
2013: Edward G Lakatta; Victor A Maltsev
Reprogramming paces the heart.
Nature biotechnology 2013;31(1):31-2.
2013: Angelo Scuteri; Edward G Lakatta
Bringing prevention in geriatrics: evidences from cardiovascular medicine supporting the new challenge.
Experimental gerontology 2013;48(1):64-8.
2012: Michael J Bround; Michael F Allard; Parisa Asghari; Kenneth R Boheler; Lubos Bohunek; Timothy J Kieffer; Edward G Lakatta; Edwin D W Moore; Marjolaine Philit; Claire Smits; Richard B Wambolt; James D Johnson
Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.
Cardiovascular research 2012;96(3):372-80.
2012: Liqun Jiang; Robert Monticone; Richard Telljohann; Mingyi Wang; James Wu; Jing Zhang; Edward G Lakatta
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Hypertension 2012;60(5):1192-9.
2012: Dongmei Yang; Bruce D Ziman; Yue Li; Alexey E Lyashkov; Edward G Lakatta
RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells.
Journal of molecular and cellular cardiology 2012;53(5):687-94.
2012: Ismayil Ahmet; Edward G Lakatta; Mark I Talan
Acute hemodynamic effects of erythropoietin do not mediate its cardioprotective properties.
Biology open 2012;1(10):1049-53.
2012: Francesco Giallauria; Edward G Lakatta; Marcello Maggio; Yuri Milaneschi; Marco Canepa; Palchamy Elango; Luigi Ferrucci; Toshiko Tanaka; Carlo Vigorito; James Strait
Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging.
The Journal of clinical endocrinology and metabolism 2012;97(10):3717-23.
2012: Olga V Fedorova; Vladimir A Kashkin; Edward G Lakatta; Irina O Zakharova; Alexei Y Bagrov
Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump.
Journal of hypertension 2012;30(9):1817-26.
2012: Mingyi Wang; James Wu; Jing Zhang; Liqun Jiang; Kapil Kapoor; Robert Monticone; Mark I Talan; Richard Telljohann; Edward G Lakatta
Chronic matrix metalloproteinase inhibition retards age-associated arterial proinflammation and increase in blood pressure.
Hypertension 2012;60(2):459-66.
2012: Anna Csiszar; Edward G Lakatta; William E Sonntag; Danuta Sosnowska; Mingyi Wang; Zoltan Ungvari
Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(8):811-20.
2012: Mingyi Wang; Robert P Wersto; James Wu; Jing Zhang; Mingming Zhao; Zongming Fu; Liqun Jiang; Benjamin Khazan; Alexander W Krug; Robert Monticone; Maria Pikilidou; Richard Telljohann; Jennifer E Van Eyk; Edward G Lakatta
MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling.
Aging cell 2012;11(3):500-8.
2012: Marco Canepa; Theodore P Abraham; Dmitry Abramov; Majd AlGhatrif; Claudio Brunelli; Edward G Lakatta; Yuri Milaneschi; Monika Moni; Samer S Najjar; Ramona Ramachandran; James B Strait; Luigi Ferrucci
Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging).
The American journal of cardiology 2012;109(8):1171-8.
2012: Ismayil Ahmet; Edward G Lakatta; Tia Turner; Mark I Talan
Fenoterol enantiomers do not possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2012;26(2):101-8.
2012: Anna Sheydina; Hyun-Jin Tae; Maria Volkova; Mingyi Wang; Jing Zhang; Yi Zhu; Liqun Jiang; Ondrej Juhasz; Edward G Lakatta; Maria G Perino; Kenneth R Boheler
Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats.
Aging cell 2012;11(2):350-9.
2012: Sungha Park; Edward G Lakatta
Role of inflammation in the pathogenesis of arterial stiffness.
Yonsei medical journal 2012;53(2):258-61.
2012: Angelo Scuteri; Kirill Tarasov; Manuela Uda; Christopher H Morrell; Marco Orru'; David Schlessinger; Edward G Lakatta
Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study.
Atherosclerosis 2012;221(1):189-97.
2012: Edward G Lakatta; Victor A Maltsev
Rebuttal: what I(f) the shoe doesn't fit? "The funny current has a major pacemaking role in the sinus node".
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(3):459-60.
2012: Victor A Maltsev; Edward G Lakatta
The funny current in the context of the coupled-clock pacemaker cell system.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(2):302-7.
2012: Weizhong Zhu; Aizhi Zhao; Khalid Chakir; J Kurt Chuprun; Gerald W Dorn; Arthur M Feldman; Erhe Gao; Walter J Koch; Edward G Lakatta; Natalia Petrashevskaya; Shuxun Ren; Mark Talan; Yibin Wang; Rui-Ping Xiao
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Circulation research 2012;110(2):265-74.
2012: Wen Wei; Dongmei Yang; Stéphanie Cabantous; Edward G Lakatta; Leonie Lampe; Sungha Park; Sarah S Subaran; Bhavana S Vangara; Geoffrey S Waldo; Li Lin
Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.
PloS one 2012;7(12):e50736.
2012: Yael Yaniv; Bruce D Ziman; Victor A Maltsev; Harold A Spurgeon; Edward G Lakatta
The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.
Molecules (Basel, Switzerland) 2012;17(7):8241-54.
2012: Yael Yaniv; Bruce D Ziman; Alexey E Lyashkov; Victor A Maltsev; Harold A Spurgeon; Dongmei Yang; Edward G Lakatta
Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
PloS one 2012;7(5):e37582.
2012: Paul D Chantler; Edward G Lakatta
Arterial-ventricular coupling with aging and disease.
Frontiers in physiology 2012;3():90.
2012: Mark I Talan; Ismayil Ahmet; Edward G Lakatta
Did clinical trials in which erythropoietin failed to reduce acute myocardial infarct size miss a narrow therapeutic window?
PloS one 2012;7(4):e34819.
2012: James B Strait; Edward G Lakatta
Aging-associated cardiovascular changes and their relationship to heart failure.
Heart failure clinics 2012;8(1):143-64.
2011: Amir Manbachi; Yiemeng Hoi; Edward G Lakatta; Bruce A Wasserman; David A Steinman
On the shape of the common carotid artery with implications for blood velocity profiles.
Physiological measurement 2011;32(12):1885-97.
2011: Yael Yaniv; Bruce D Ziman; Ariel L Escobar; Victor A Maltsev; Harold A Spurgeon; Michael D Stern; Edward G Lakatta
Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.
Journal of molecular and cellular cardiology 2011;51(6):902-5.
2011: Jie Liu; Victor A Maltsev; Silvia Rain; Veena Shetty; Shweta Shukla; Syevda G Sirenko; Harold A Spurgeon; Tatiana M Vinogradova; Bruce Ziman; Magdalena Juhaszova; Edward G Lakatta
A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.
Journal of molecular and cellular cardiology 2011;51(5):730-9.
2011: Yael Yaniv; Magdalena Juhaszova; Alexey E Lyashkov; STEVEN SOLLOTT; Harold A Spurgeon; Edward G Lakatta
Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.
Journal of molecular and cellular cardiology 2011;51(5):740-8.
2011: Antoine Younès; Edward G Lakatta; Yevgeniya O Lukyanenko; Alexey E Lyashkov; STEVEN SOLLOTT
A bioluminescence method for direct measurement of phosphodiesterase activity.
Analytical biochemistry 2011;417(1):36-40.
2011: Mark I Talan; Rui-Ping Xiao; Ismayil Ahmet; Edward G Lakatta
β₂ AR agonists in treatment of chronic heart failure: long path to translation.
Journal of molecular and cellular cardiology 2011;51(4):529-33.
2011: Sungha Park; Jeong B Park; Edward G Lakatta
Association of central hemodynamics with estimated 24-h urinary sodium in patients with hypertension.
Journal of hypertension 2011;29(8):1502-7.
2011: Zoltan Ungvari; Mingyi Wang; Lora Bailey-Downs; Raphael de Cabo; Tripti Gautam; Edward G Lakatta; Robert E Monticone; John Pinto; William E Sonntag; Danuta Sosnowska; Richard Telljohann; Anna Csiszar
Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(8):866-75.
2011: Ismayil Ahmet; Rafael de Cabo; Edward G Lakatta; Hyun-Jin Tae; Mark I Talan
Effects of calorie restriction on cardioprotection and cardiovascular health.
Journal of molecular and cellular cardiology 2011;51(2):263-71.
2011: Victor A Maltsev; Tatiana M Vinogradova; Michael D Stern; Edward G Lakatta
Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".
American journal of physiology. Heart and circulatory physiology 2011;300(6):H2323-4; author reply H2325-6.
2011: Khalid Chakir; Weizhong Zhu; Sharon Tsang; Anthony Yiu-Ho Woo; Dongmei Yang; Xianhua Wang; Xiaokun Zeng; Man-Hee Rhee; Ulrike Mende; Norimichi Koitabashi; Eiki Takimoto; Kendall J Blumer; Edward G Lakatta; David A Kass; Rui-Ping Xiao
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
Journal of molecular and cellular cardiology 2011;50(6):1000-7.
2011: Samer S Najjar; Sunil V Rao; Chiara Melloni; Subha V Raman; Thomas J Povsic; Laura Melton; Gregory W Barsness; Kristi Prather; John F Heitner; Rakhi Kilaru; Luis Gruberg; Vic Hasselblad; Adam B Greenbaum; Manesh Patel; Raymond J Kim; Mark Talan; Luigi Ferrucci; Dan L Longo; Edward G Lakatta; Robert A Harrington
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2011;305(18):1863-72.
2011: Paul D Chantler; Amit Nussbacher; Gary Gerstenblith; Steven P Schulman; Lewis C Becker; Luigi Ferrucci; Jerome L Fleg; Edward G Lakatta; Samer S Najjar
Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside.
American journal of physiology. Heart and circulatory physiology 2011;300(5):H1914-22.
2011: M Sangeetha; Malini S Pillai; Linda Philip; Edward G Lakatta; K Shivakumar
NF-κB inhibition compromises cardiac fibroblast viability under hypoxia.
Experimental cell research 2011;317(7):899-909.
2011: ANGELO SCUTERI; Marco Orru; Christopher Morrell; Maria Grazia Piras; Dennis Taub; David Schlessinger; Manuela Uda; Edward G Lakatta
Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study.
Atherosclerosis 2011;215(2):459-64.
2011: Chi-Ming Huang; Kang-Ling Wang; Hao-Min Cheng; Shao-Yuan Chuang; Shih-Hsien Sung; Wen-Chung Yu; Chih-Tai Ting; Edward G Lakatta; Frank Cp Yin; Pesus Chou; Chen-Huan Chen
Central versus ambulatory blood pressure in the prediction of all-cause and cardiovascular mortalities.
Journal of hypertension 2011;29(3):454-9.
2011: Ismayil Ahmet; Hyun-Jin Tae; Magdalena Juhaszova; Daniel R Riordon; Kenneth R Boheler; STEVEN SOLLOTT; Michael Brines; Anthony Cerami; Edward G Lakatta; Mark I Talan
A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage.
Molecular medicine (Cambridge, Mass.) 2011;17(3-4):194-200.
2011: Anna V Maltsev; Victor A Maltsev; Maxim Mikheev; Larissa A Maltseva; Syevda G Sirenko; Edward G Lakatta; Michael D Stern
Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cells.
Biophysical journal 2011;100(2):271-83.
2011: Xiao-Chen Li; Ling Wei; Guang-Qin Zhang; Peng Zhou; Shu-Hua Bai; Zai-Ling Bai; Zhen Chai; Xue-Mei Hao; Ying-Ying Hu; Edward G Lakatta; Shi-Qiang Wang
Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.
PloS one 2011;6(9):e24787.
2011: Mingyi Wang; Gaia Spinetti; Robert Monticone; Jing Zhang; James Wu; Liqun Jiang; Benjamin Khazan; Richard Telljohann; Edward G Lakatta
A local proinflammatory signalling loop facilitates adverse age-associated arterial remodeling.
PloS one 2011;6(2):e16653.
2011: Nora L Watson; Kim Sutton-Tyrrell; Ada O Youk; Robert M Boudreau; Rachel H Mackey; Eleanor M Simonsick; Caterina Rosano; Susan E Hardy; B Gwen Windham; Tamara B Harris; Samer S Najjar; Edward G Lakatta; Hal H Atkinson; Karen C Johnson; Douglas Charles Bauer; Anne B Newman; Anne B Nemwan
Arterial stiffness and gait speed in older adults with and without peripheral arterial disease.
American journal of hypertension 2011;24(1):90-5.
2011: Ihor Zahanich; Syevda G Sirenko; Larissa A Maltseva; Yelena S Tarasova; Harold A Spurgeon; Kenneth R Boheler; Michael D Stern; Edward G Lakatta; Victor A Maltsev
Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling.
Journal of molecular and cellular cardiology 2011;50(1):66-76.
2010: Yiemeng Hoi; Bruce A Wasserman; Edward G Lakatta; David A Steinman
Effect of common carotid artery inlet length on normal carotid bifurcation hemodynamics.
Journal of biomechanical engineering 2010;132(12):121008.
2010: Zhuoli Zhang; Brynne Hancock; Stephanie Leen; Sharan Ramaswamy; STEVEN SOLLOTT; Kenneth R Boheler; Magdalena Juhaszova; Edward G Lakatta; RICHARD SPENCER; Kenneth W Fishbein
Compatibility of superparamagnetic iron oxide nanoparticle labeling for ¹H MRI cell tracking with ³¹P MRS for bioenergetic measurements.
NMR in biomedicine 2010;23(10):1166-72.
2010: Chiara Melloni; Sunil V Rao; Thomas J Povsic; Laura Melton; Raymond J Kim; Rakhi Kilaru; Manesh R Patel; Mark Talan; Luigi Ferrucci; Dan L Longo; Edward G Lakatta; Samer S Najjar; Robert A Harrington
Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.
American heart journal 2010;160(5):795-803.e2.
2010: Ismayil Ahmet; Ruiqian Wan; Mark P Mattson; Edward G Lakatta; Mark I Talan
Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats.
Journal of cardiac failure 2010;16(10):843-53.
2010: Angelina R Sutin; ANGELO SCUTERI; Edward G Lakatta; Kirill V Tarasov; Luigi Ferrucci; Paul T Costa; David Schlessinger; Manuela Uda; Antonio Terracciano
Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men.
Hypertension 2010;56(4):617-22.
2010: David G Le Couteur; Edward G Lakatta
A vascular theory of aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(10):1025-7.
2010: Tené T Lewis; Kim Sutton-Tyrrell; Brenda W Penninx; Nicole Vogelzangs; Tamara B Harris; Georgeta D Vaidean; Hilsa N Ayonayon; Lauren Kim; Edward G Lakatta; Anne B Newman
Race, psychosocial factors, and aortic pulse wave velocity: the Health, Aging, and Body Composition Study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(10):1079-85.
2010: Tatiana M Vinogradova; Didier Brochet; Syevda G Sirenko; Yue Li; Harold A Spurgeon; Edward G Lakatta
Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.
Circulation research 2010;107(6):767-75.
2010: Andrzej M Janczewski; Edward G Lakatta
Modulation of sarcoplasmic reticulum Ca(2+) cycling in systolic and diastolic heart failure associated with aging.
Heart failure reviews 2010;15(5):431-45.
2010: Yiemeng Hoi; Bruce A Wasserman; Edward G Lakatta; David A Steinman
Carotid bifurcation hemodynamics in older adults: effect of measured versus assumed flow waveform.
Journal of biomechanical engineering 2010;132(7):071006.
2010: Ira R Josephson; Antonio Guia; Eric A Sobie; W Jonathan Lederer; Edward G Lakatta; Michael D Stern
Physiologic gating properties of unitary cardiac L-type Ca2+ channels.
Biochemical and biophysical research communications 2010;396(3):763-6.
2010: Alexander W Krug; Lena Allenhöfer; Robert Monticone; Gaia Spinetti; Michael Gekle; Mingyi Wang; Edward G Lakatta
Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways.
Hypertension 2010;55(6):1476-83.
2010: Victor A Maltsev; Edward G Lakatta
A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2010-23.
2010: Angelina R Sutin; Antonio Terracciano; Barbara Deiana; Manuela Uda; David Schlessinger; Edward G Lakatta; Paul T Costa
Cholesterol, triglycerides, and the Five-Factor Model of personality.
Biological psychology 2010;84(2):186-91.
2010: Edward G Lakatta
A paradigm shift for the heart's pacemaker.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(4):559-64.
2010: Mingyi Wang; Jing Zhang; Simon J Walker; Rafal Dworakowski; Edward G Lakatta; Ajay M Shah
Involvement of NADPH oxidase in age-associated cardiac remodeling.
Journal of molecular and cellular cardiology 2010;48(4):765-72.
2010: Victor A Maltsev; Edward G Lakatta
Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells.
Journal of molecular and cellular cardiology 2010;48(4):804-6.
2010: Edward G Lakatta; Victor A Maltsev; Tatiana M Vinogradova
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.
Circulation research 2010;106(4):659-73.
2010: Yiemeng Hoi; Bruce A Wasserman; Yuanyuan J Xie; Samer S Najjar; Luigi Ferrucci; Edward G Lakatta; Gary Gerstenblith; David A Steinman
Characterization of volumetric flow rate waveforms at the carotid bifurcations of older adults.
Physiological measurement 2010;31(3):291-302.
2010: Kang-Ling Wang; Hao-Min Cheng; Shih-Hsien Sung; Shao-Yuan Chuang; Cheng-Hung Li; Harold A Spurgeon; Chih-Tai Ting; Samer S Najjar; Edward G Lakatta; Frank C P Yin; Pesus Chou; Chen-Huan Chen
Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study.
Hypertension 2010;55(3):799-805.
2010: Mingyi Wang; Robert E Monticone; Edward G Lakatta
Arterial aging: a journey into subclinical arterial disease.
Current opinion in nephrology and hypertension 2010;19(2):201-7.
2010: ANGELO SCUTERI; Samer S Najjar; Marco Orru'; Gianluca Usala; Maria Grazia Piras; Luigi Ferrucci; Antonio Cao; David Schlessinger; Manuela Uda; Edward G Lakatta
The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study.
European heart journal 2010;31(5):602-13.
2010: Yael Yaniv; Magdalena Juhaszova; H Bradley Nuss; Su Wang; Dmitry B Zorov; Edward G Lakatta; STEVEN SOLLOTT
Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives.
Annals of the New York Academy of Sciences 2010;1188():133-42.
2010: Victor A Maltsev; Edward G Lakatta
Yin and yang of the cardiac pacemaker clock system in health and disease.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(1):96-8.
2010: Ira R Josephson; Antonio Guia; Edward G Lakatta; W Jonathan Lederer; Michael D Stern
Ca(2+)-dependent components of inactivation of unitary cardiac L-type Ca(2+) channels.
The Journal of physiology 2010;588(Pt 1):213-23.
2009: Hannes Reuter; William E Louch; Fabien Brette; James Sham; Hui Sun; Xiao-Ru Yang; Christian Soeller; Edward G Lakatta; Ravi C Balijepalli
Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;107(6):1985-7; author reply 1988.
2009: Peng Zhou; Yan-Ting Zhao; Yun-Bo Guo; Shi-Ming Xu; Shu-Hua Bai; Edward G Lakatta; Heping Cheng; Xue-Mei Hao; Shi-Qiang Wang
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):18028-33.
2009: Ismayil Ahmet; Chris Morrell; Edward G Lakatta; Mark I Talan
Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor.
The Journal of pharmacology and experimental therapeutics 2009;331(1):178-85.
2009: Tatiana M Vinogradova; Edward G Lakatta
Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.
Journal of molecular and cellular cardiology 2009;47(4):456-74.
2009: Paul D Chantler; Edward G Lakatta
Role of body size on cardiovascular function: can we see the meat through the fat?
Hypertension 2009;54(3):459-61.
2009: Alexey E Lyashkov; Tatiana M Vinogradova; Ihor Zahanich; Yue Li; Antoine Younes; H Bradley Nuss; Harold A Spurgeon; Victor A Maltsev; Edward G Lakatta
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
American journal of physiology. Heart and circulatory physiology 2009;297(3):H949-59.
2009: Edward G Lakatta; Dario DiFrancesco
What keeps us ticking: a funny current, a calcium clock, or both?
Journal of molecular and cellular cardiology 2009;47(2):157-70.
2009: Zongming Fu; Mingyi Wang; Marjan Gucek; Jing Zhang; James Wu; Liqun Jiang; Robert Monticone; Benjamin Khazan; Richard Telljohann; Julie Mattison; Simon Sheng; Robert N Cole; Gaia Spinetti; Gianfranco Pintus; Lijuan Liu; Frank D Kolodgie; Renu Virmani; Harold A Spurgeon; Donald Ingram; Allen Everett; Edward G Lakatta; Jennifer E Van Eyk
Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion.
Circulation research 2009;104(12):1337-46.
2009: John Pang; Xiaokun Zeng; Rui-ping Xiao; Edward G Lakatta; Li Lin
Design, generation, and testing of mammalian expression modules that tag membrane proteins.
Protein science : a publication of the Protein Society 2009;18(6):1261-71.
2009: Edward G Lakatta; Mingyi Wang; Samer S Najjar
Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.
The Medical clinics of North America 2009;93(3):583-604, Table of Contents.
2009: Tina E Brinkley; Barbara J Nicklas; Alka M Kanaya; Suzanne Satterfield; Edward G Lakatta; Eleanor M Simonsick; Kim Sutton-Tyrrell; Stephen B Kritchevsky
Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study.
Hypertension 2009;53(5):846-52.
2009: ANGELO SCUTERI; Christopher H Morrell; Samer S Najjar; Denis Muller; Reubin Andres; Luigi Ferrucci; Edward G Lakatta
Longitudinal paths to the metabolic syndrome: can the incidence of the metabolic syndrome be predicted? The Baltimore Longitudinal Study of Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(5):590-8.
2009: Kirill V Tarasov; serena Sanna; ANGELO SCUTERI; James B Strait; Marco Orrù; Afshin Parsa; Ping-I Lin; Andrea Maschio; Sandra Lai; Maria Grazia Piras; Marco Masala; Toshiko Tanaka; Wendy S Post; Jeffrey R O'Connell; David Schlessinger; Antonio Cao; Ramaiah Nagaraja; Braxton D Mitchell; Goncalo Abecasis; Alan R Shuldiner; Manuela Uda; Edward G Lakatta; Samer S Najjar
COL4A1 is associated with arterial stiffness by genome-wide association scan.
Circulation. Cardiovascular genetics 2009;2(2):151-8.
2009: James B Strait; Manuela Uda; Edward G Lakatta; Samer S Najjar
Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
Trends in cardiovascular medicine 2009;19(3):69-75.
2009: Kang-Ling Wang; Hao-Min Cheng; Shao-Yuan Chuang; Harold A Spurgeon; Chih-Tai Ting; Edward G Lakatta; Frank C P Yin; Pesus Chou; Chen-Huan Chen
Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
Journal of hypertension 2009;27(3):461-7.
2009: Victor A Maltsev; Edward G Lakatta
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H594-615.
2009: Li Lin; Sungha Park; Edward G Lakatta
RAGE signaling in inflammation and arterial aging.
Frontiers in bioscience : a journal and virtual library 2009;14():1403-13.
2009: Su Wang; Bruce D Ziman; Ilona Bodi; Marta Rubio; Ying-Ying Zhou; Karen D'Souza; Nanette H Bishopric; Arnold Schwartz; Edward G Lakatta
Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse.
PloS one 2009;4(1):e4133.
2009: Mingyi Wang; Edward G Lakatta
The salted artery and angiotensin II signaling: a deadly duo in arterial disease.
Journal of hypertension 2009;27(1):19-21.
2008: Olga V Fedorova; Andrey S Simbirtsev; Nikolai I Kolodkin; Alexander Y Kotov; Natalia I Agalakova; Vladimir A Kashkin; Natalia I Tapilskaya; Anton Bzhelyansky; Vitaly A Reznik; Elena V Frolova; Elena R Nikitina; Georgy V Budny; Dan Longo; Edward G Lakatta; Alexei Y Bagrov
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.
Journal of hypertension 2008;26(12):2414-25.
2008: Edward G Lakatta
Arterial aging is risky.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1321-2.
2008: Paul D Chantler; Edward G Lakatta; Samer S Najjar
Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1342-51.
2008: Anna Csiszar; Mingyi Wang; Edward G Lakatta; Zoltan Ungvari
Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1333-41.
2008: Wang Wang; Huaqiang Fang; Linda Groom; Aiwu Cheng; Wanrui Zhang; Jie Liu; Xianhua Wang; Kaitao Li; Peidong Han; Ming Zheng; Jinhu Yin; Weidong Wang; Mark P Mattson; Joseph Kao; Edward G Lakatta; Shey-Shing Sheu; Kunfu Ouyang; Ju Chen; Robert T Dirksen; Heping Cheng
Superoxide flashes in single mitochondria.
Cell 2008;134(2):279-90.
2008: Paul D Chantler; Vojtech Melenovsky; Steven P Schulman; Gary Gerstenblith; Lewis C Becker; Luigi Ferrucci; Jerome L Fleg; Edward G Lakatta; Samer S Najjar
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H145-53.
2008: Antoine Younes; Alexey E Lyashkov; David Raymond Graham; Anna Sheydina; Maria V Volkova; Megan Mitsak; Tatiana M Vinogradova; Yevgeniya O Lukyanenko; Yue Li; Abdul M Ruknudin; Kenneth R Boheler; Jennifer E Van Eyk; Edward G Lakatta
Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.
The Journal of biological chemistry 2008;283(21):14461-8.
2008: Ismayil Ahmet; Melissa Krawczyk; Weizhong Zhu; Anthony Woo; Christopher Morrell; Suresh Poosala; Rui-Ping Xiao; Edward G Lakatta; Mark I Talan
Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.
The Journal of pharmacology and experimental therapeutics 2008;325(2):491-9.
2008: Tatiana M Vinogradova; Syevda G Sirenko; Alexey E Lyashkov; Antoine Younes; Yue Li; Weizhong Zhu; Dongmei Yang; Abdul M Ruknudin; Harold A Spurgeon; Edward G Lakatta
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.
Circulation research 2008;102(7):761-9.
2008: Samer S Najjar; ANGELO SCUTERI; Veena Shetty; Jeanette G Wright; Denis C Muller; Jerome L Fleg; Harold P Spurgeon; Luigi Ferrucci; Edward G Lakatta
Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.
Journal of the American College of Cardiology 2008;51(14):1377-83.
2008: David E Anderson; Olga V Fedorova; Christopher H Morrell; Dan Longo; Vladimir A Kashkin; Jessica D Metzler; Alexei Y Bagrov; Edward G Lakatta
Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1248-54.
2008: Edward G Lakatta; Tatiana M Vinogradova; Victor A Maltsev
The missing link in the mystery of normal automaticity of cardiac pacemaker cells.
Annals of the New York Academy of Sciences 2008;1123():41-57.
2008: S Morteza Farasat; Christopher H Morrell; ANGELO SCUTERI; Chih-Tai Ting; Frank C P Yin; Harold A Spurgeon; Chen-Huan Chen; Edward G Lakatta; Samer S Najjar
Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension.
Hypertension 2008;51(2):196-202.
2008: Victor A Maltsev; Edward G Lakatta
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function.
Cardiovascular research 2008;77(2):274-84.
2008: Liqun Jiang; Mingyi Wang; Jing Zhang; Robert Monticone; Richard Telljohann; Gaia Spinetti; Gianfranco Pintus; Edward G Lakatta
Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells.
PloS one 2008;3(5):e2231.
2008: Vladimir A Kashkin; Edwin E Zvartau; Olga V Fedorova; Yakov Y Bagrov; Edward G Lakatta; Alexei Y Bagrov
Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(1):74-7.
2007: Patrick McConville; Edward G Lakatta; RICHARD SPENCER
Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1828-35.
2007: Jacob M Zahn; Suresh Poosala; Art B Owen; Donald Ingram; Ana Lustig; Arnell Carter; Ashani T Weeraratna; Dennis D Taub; Myriam Gorospe; Krystyna Mazan-Mamczarz; Edward G Lakatta; Kenneth R Boheler; Xiangru Xu; Mark P Mattson; Geppino Falco; Minoru S H Ko; David Schlessinger; Jeffrey Firman; Sarah K Kummerfeld; William H Wood; Alan B Zonderman; Stuart K Kim; Kevin G Becker
AGEMAP: a gene expression database for aging in mice.
PLoS genetics 2007;3(11):e201.
2007: Victor A Maltsev; Edward G Lakatta
Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells.
Heart, lung & circulation 2007;16(5):335-48.
2007: Edward G Lakatta
Central arterial aging and the epidemic of systolic hypertension and atherosclerosis.
Journal of the American Society of Hypertension : JASH 2007;1(5):302-40.
2007: Olga V Fedorova; Igor A Zhuravin; Natalia I Agalakova; Liubov A Yamova; Mark I Talan; Edward G Lakatta; Alexei Y Bagrov
Intrahippocampal microinjection of an exquisitely low dose of ouabain mimics NaCl loading and stimulates a bufadienolide Na/K-ATPase inhibitor.
Journal of hypertension 2007;25(9):1834-44.
2007: Mingyi Wang; Jing Zhang; Li-Qun Jiang; Gaia Spinetti; Gianfranco Pintus; Robert Monticone; Frank D Kolodgie; Renu Virmani; Edward G Lakatta
Proinflammatory profile within the grossly normal aged human aortic wall.
Hypertension 2007;50(1):219-27.
2007: Alexey E Lyashkov; Magdalena Juhaszova; Halina Dobrzynski; Tatiana M Vinogradova; Victor A Maltsev; Ondrej Juhasz; Harold A Spurgeon; STEVEN SOLLOTT; Edward G Lakatta
Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size.
Circulation research 2007;100(12):1723-31.
2007: Abdul M Ruknudin; Edward G Lakatta
The regulation of the Na/Ca exchanger and plasmalemmal Ca2+ ATPase by other proteins.
Annals of the New York Academy of Sciences 2007;1099():86-102.
2007: Paul T Costa; Antonio Terracciano; Manuela Uda; Loredana Vacca; Cinzia Mameli; Giuseppe Pilia; Alan B Zonderman; Edward G Lakatta; David Schlessinger; Robert R McCrae
Personality traits in Sardinia: testing founder population effects on trait means and variances.
Behavior genetics 2007;37(2):376-87.
2007: Dongmei Yang; Wei-Zhong Zhu; Bailong Xiao; Didier Brochet; S R Wayne Chen; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Circulation research 2007;100(3):399-407.
2007: Victor A Maltsev; Edward G Lakatta
Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia.
Journal of molecular and cellular cardiology 2007;42(2):289-94.
2007: Vojtech Melenovsky; Vojtech Melenovsky; Boaz Rosen; Ilan Hay; Luigi Ferrucci; Christopher H Morell; Edward G Lakatta; Samer S Najjar; David A Kass
Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction.
Journal of the American College of Cardiology 2007;49(2):198-207.
2006: Olga V Fedorova; Natalia I Agalakova; Christopher H Morrell; Edward G Lakatta; Alexei Y Bagrov
ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta.
Hypertension 2006;48(6):1160-8.
2006: Joseph A Baur; Kevin J Pearson; Nathan L Price; Hamish A Jamieson; Carles Lerin; Avash Kalra; Vinayakumar V Prabhu; Joanne S Allard; Guillermo Lopez-LLuch; Kaitlyn Lewis; Paul J Pistell; Suresh Poosala; Kevin G Becker; Olivier Boss; Dana Gwinn; Mingyi Wang; Sharan Ramaswamy; Kenneth W Fishbein; RICHARD SPENCER; Edward G Lakatta; DAVID LE COUTEUR; Reuben J. Shaw; Plácido Navas; Pere Puigserver; Donald Ingram; Rafael de Cabo; David A Sinclair
Resveratrol improves health and survival of mice on a high-calorie diet.
Nature 2006;444(7117):337-42.
2006: Konstantin Y Bogdanov; Victor A Maltsev; Tatiana M Vinogradova; Alexey E Lyashkov; Harold A Spurgeon; Michael D Stern; Edward G Lakatta
Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state.
Circulation research 2006;99(9):979-87.
2006: Edward G Lakatta; Tatiana M Vinogradova; Alexey E Lyashkov; Syevda G Sirenko; Weizong Zhu; Abdul M Ruknudin; Victor A Maltsev
The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.
Annals of the New York Academy of Sciences 2006;1080():178-206.
2006: Giuseppe Pilia; Wei-Min Chen; ANGELO SCUTERI; Marco Orrú; Giuseppe Albai; Mariano Dei; Sandra Lai; Gianluca Usala; Monica Lai; Paola Loi; Cinzia Mameli; Loredana Vacca; Manila Deiana; Nazario Olla; Marco Masala; Antonio Cao; Samer S Najjar; Antonio Terracciano; Timur Nedorezov; Alexei Sharov; Alan B Zonderman; Goncalo Abecasis; Paul Costa; Edward G Lakatta; David Schlessinger
Heritability of cardiovascular and personality traits in 6,148 Sardinians.
PLoS genetics 2006;2(8):e132.
2006: Chanil Moon; Melissa Krawczyk; Edward G Lakatta; Mark I Talan
Therapeutic effectiveness of a single vs multiple doses of erythropoietin after experimental myocardial infarction in rats.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(4):245-51.
2006: Mingyi Wang; Di Zhao; Gaia Spinetti; Jing Zhang; Li-Qun Jiang; Gianfranco Pintus; Robert Monticone; Edward G Lakatta
Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1503-9.
2006: Rui-Ping Xiao; Weizhong Zhu; Ming Zheng; Chunmei Cao; Youyi Zhang; Edward G Lakatta; Qide Han
Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart.
Trends in pharmacological sciences 2006;27(6):330-7.
2006: Edward G Lakatta; Paul D Chantler
Payments for debts associated with exercise can become higher as we age and limit exercise capacity.
Journal of the American College of Cardiology 2006;47(5):1058-9.
2006: Tatiana M Vinogradova; Alexey E Lyashkov; Weizhong Zhu; Abdul M Ruknudin; Syevda G Sirenko; Dongmei Yang; Shekhar Deo; Matthew Barlow; Shavsha Johnson; James L Caffrey; Ying-Ying Zhou; Rui-Ping Xiao; Heping Cheng; Michael D Stern; Victor A Maltsev; Edward G Lakatta
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Circulation research 2006;98(4):505-14.
2006: David Kennedy; Sandeep Vetteth; Sankaridrug M Periyasamy; Mohamed Kanj; Larisa Fedorova; Samer Khouri; M Bashar Kahaleh; Zijian Xie; Deepak Malhotra; Nikolai I Kolodkin; Edward G Lakatta; Olga V Fedorova; Alexei Y Bagrov; Joseph Shapiro
Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.
Hypertension 2006;47(3):488-95.
2006: Chanil Moon; Melissa Krawczyk; Doojin Paik; Thomas Coleman; Michael Brines; Magdalena Juhaszova; STEVEN SOLLOTT; Edward G Lakatta; Mark I Talan
Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties.
The Journal of pharmacology and experimental therapeutics 2006;316(3):999-1005.
2006: Hidetaka Hougaku; Jerome L Fleg; Samer S Najjar; Edward G Lakatta; S Mitchell Harman; Marc R Blackman; E Jeffrey Metter
Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements.
American journal of physiology. Endocrinology and metabolism 2006;290(2):E234-42.
2006: I V Averina; N I Tapilskaya; V A Reznik; Elena V Frolova; Olga V Fedorova; Edward G Lakatta; Alexei Y Bagrov
Endogenous Na/K-ATPase inhibitors in patients with preeclampsia.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(8):19-23.
2006: Victor A Maltsev; Tatiana M Vinogradova; Edward G Lakatta
The emergence of a general theory of the initiation and strength of the heartbeat.
Journal of pharmacological sciences 2006;100(5):338-69.
2005: Ismayil Ahmet; Edward G Lakatta; Mark I Talan
Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy.
Heart failure reviews 2005;10(4):289-96.
2005: Ismayil Ahmet; Ruiqian Wan; Mark P Mattson; Edward G Lakatta; Mark I Talan
Cardioprotection by intermittent fasting in rats.
Circulation 2005;112(20):3115-21.
2005: Mingyi Wang; Jing Zhang; Gaia Spinetti; Li-Qun Jiang; Robert Monticone; Di Zhao; Linda Cheng; Melissa Krawczyk; Mark I Talan; Gianfranco Pintus; Edward G Lakatta
Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.
The American journal of pathology 2005;167(5):1429-42.
2005: Antoine Younès; Salvatore Pepe; Darice Yoshishige; James L Caffrey; Edward G Lakatta
Ischemic preconditioning increases the bioavailability of cardiac enkephalins.
American journal of physiology. Heart and circulatory physiology 2005;289(4):H1652-61.
2005: Samer S Najjar; ANGELO SCUTERI; Edward G Lakatta
Arterial aging: is it an immutable cardiovascular risk factor?
Hypertension 2005;46(3):454-62.
2005: Patrick McConville; RICHARD SPENCER; Edward G Lakatta
Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1- and beta2-AR stimulation in the isolated, perfused rat heart.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E412-8.
2005: Wei-Zhong Zhu; Khalid Chakir; Shengjun Zhang; Dongmei Yang; Catherine Lavoie; Michel Bouvier; Terence E Hébert; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.
Circulation research 2005;97(3):244-51.
2005: Jerome L Fleg; Christopher H Morrell; Angelo G Bos; Larry J Brant; Laura A Talbot; Jeanette G Wright; Edward G Lakatta
Accelerated longitudinal decline of aerobic capacity in healthy older adults.
Circulation 2005;112(5):674-82.
2005: Chanil Moon; Melissa Krawczyk; Doojin Paik; Edward G Lakatta; Mark I Talan
Cardioprotection by recombinant human erythropoietin following acute experimental myocardial infarction: dose response and therapeutic window.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2005;19(4):243-50.
2005: Richard J Havlik; Caroline L Phillips; Dwight B Brock; Kurt Lohman; William Haskell; Peter Snell; Mary O'Toole; Paul Ribisl; Peter Vietas Vaitkevicius; Harold A Spurgeon; Edward G Lakatta; Paul Pullen
Walking may be related to less vascular stiffness in the Activity Counseling Trial (ACT).
American heart journal 2005;150(2):270-5.
2005: Olga V Fedorova; Natalia I Agalakova; Mark I Talan; Edward G Lakatta; Alexei Y Bagrov
Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats.
Journal of hypertension 2005;23(8):1515-23.
2005: ANGELO SCUTERI; Samer S Najjar; Denis Muller; Reubin Andres; Christopher H Morrell; Alan B Zonderman; Edward G Lakatta
apoE4 allele and the natural history of cardiovascular risk factors.
American journal of physiology. Endocrinology and metabolism 2005;289(2):E322-7.
2005: Kim Sutton-Tyrrell; Samer S Najjar; Robert M Boudreau; Lakshmi Venkitachalam; Varant Kupelian; Eleanor M Simonsick; Richard Havlik; Edward G Lakatta; Harold A Spurgeon; Stephen B Kritchevsky; Marco Pahor; Douglas Bauer; Anne Newman
Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
Circulation 2005;111(25):3384-90.
2005: Tatiana M Vinogradova; Victor A Maltsev; Konstantin Y Bogdanov; Alexey E Lyashkov; Edward G Lakatta
Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.
Annals of the New York Academy of Sciences 2005;1047():138-56.
2005: Atsushi Sanbe; Jeanne James; Volkan Tuzcu; Selman Nas; Lisa Martin; James Gulick; Hanna Osinska; Sadayappan Sakthivel; Raisa Klevitsky; Kenneth S Ginsburg; Donald M Bers; Bruce Zinman; Edward G Lakatta; Jeffrey Robbins
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.
Circulation 2005;111(18):2330-8.
2005: Magdalena Juhaszova; Christophe Rabuel; Dmitry B Zorov; Edward G Lakatta; STEVEN SOLLOTT
Protection in the aged heart: preventing the heart-break of old age?
Cardiovascular research 2005;66(2):233-44.
2005: Salvatore Pepe; Edward G Lakatta
Aging hearts and vessels: masters of adaptation and survival.
Cardiovascular research 2005;66(2):190-3.
2005: Hidetaka Hougaku; Jerome L Fleg; Edward G Lakatta; ANGELO SCUTERI; Christopher J Earley; Samer S Najjar; Saswata Deb; E Jeffrey Metter
Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening.
The American journal of cardiology 2005;95(8):1006-10.
2005: ANGELO SCUTERI; Samer S Najjar; Christopher H Morrell; Edward G Lakatta
The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study.
Diabetes care 2005;28(4):882-7.
2005: Olga V Fedorova; Nikolai I Kolodkin; Natalia I Agalakova; Alexandra R Namikas; Anton Bzhelyansky; Jean St-Louis; Edward G Lakatta; Alexei Y Bagrov
Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake.
Journal of hypertension 2005;23(4):835-42.
2005: Evgeny Kobrinsky; Swasti Tiwari; Victor A Maltsev; Jo Beth Harry; Edward G Lakatta; Darrell R. Abernethy; Nikolai M Soldatov
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.
The Journal of biological chemistry 2005;280(13):12474-85.
2005: Evan C Hadley; Edward G Lakatta; Marcelle Morrison-Bogorad; Huber R Warner; Richard J Hodes
The future of aging therapies.
Cell 2005;120(4):557-67.
2005: Marvin O Boluyt; Kathleen G Robinson; Andrea L Meredith; Subha Sen; Edward G Lakatta; Michael T Crow; Wesley W Brooks; Chester H Conrad; Oscar H L Bing
Heart failure after long-term supravalvular aortic constriction in rats.
American journal of hypertension 2005;18(2 Pt 1):202-12.
2004: Veronique Leblais; Su-Hyun Jo; Khalid Chakir; Victor A Maltsev; Ming Zheng; Michael T Crow; Wang Wang; Edward G Lakatta; Rui-Ping Xiao
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Circulation research 2004;95(12):1183-90.
2004: Guimei Wu; José Marín-García; Terry B Rogers; Edward G Lakatta; Xilin Long
Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes.
Journal of cardiac failure 2004;10(6):519-26.
2004: Ismayil Ahmet; Melissa Krawczyk; Phillip Heller; Chanil Moon; Edward G Lakatta; Mark I Talan
Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy.
Circulation 2004;110(9):1083-90.
2004: Salvatore Pepe; Olivier W V van den Brink; Edward G Lakatta; Rui-Ping Xiao
Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart.
Cardiovascular research 2004;63(3):414-22.
2004: Samer S Najjar; Steven P Schulman; Gary Gerstenblith; Jerome L Fleg; David A Kass; Frances C O'Connor; Lewis C Becker; Edward G Lakatta
Age and gender affect ventricular-vascular coupling during aerobic exercise.
Journal of the American College of Cardiology 2004;44(3):611-7.
2004: Gaia Spinetti; Mingyi Wang; Robert Monticone; Jing Zhang; Di Zhao; Edward G Lakatta
Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1397-402.
2004: Edward G Lakatta; Steven P Schulman
Age-associated cardiovascular changes are the substrate for poor prognosis with myocardial infarction.
Journal of the American College of Cardiology 2004;44(1):35-7.
2004: Rui-Ping Xiao; Weizhong Zhu; Ming Zheng; Khalid Chakir; Richard Bond; Edward G Lakatta; Heping Cheng
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.
Trends in pharmacological sciences 2004;25(7):358-65.
2004: Alexei Y Bagrov; Edward G Lakatta
The dietary sodium-blood pressure plot "stiffens".
Hypertension 2004;44(1):22-4.
2004: Edward G Lakatta
Beyond Bowditch: the convergence of cardiac chronotropy and inotropy.
Cell calcium 2004;35(6):629-42.
2004: ANGELO SCUTERI; Samer S Najjar; Denis C Muller; Reubin Andres; Hidetaka Hougaku; E Jeffrey Metter; Edward G Lakatta
Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness.
Journal of the American College of Cardiology 2004;43(8):1388-95.
2004: Tatiana M Vinogradova; Ying-Ying Zhou; Victor A Maltsev; Alexey E Lyashkov; Michael Stern; Edward G Lakatta
Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization.
Circulation research 2004;94(6):802-9.
2004: Victor A Maltsev; Tatiana M Vinogradova; Konstantin Y Bogdanov; Edward G Lakatta; Michael D Stern
Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.
Biophysical journal 2004;86(4):2596-605.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Dongchoon Ahn; Linda Cheng; Chanil Moon; Harold A Spurgeon; Edward G Lakatta; Mark I Talan
Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice.
American journal of physiology. Heart and circulatory physiology 2004;286(3):H1201-7.
2004: Zhang Guangqin; Fu Yu; Yang Dongmei; Hao Xuemei; Bai Shuhua; Tang Yiqun; Edward G Lakatta; Wu Caihong; Cheng Heping
Contribution of spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocytes.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2004;47(1):31-7.
2004: Olga V Fedorova; Mark I Talan; Natalia I Agalakova; Edward G Lakatta; Alexei Y Bagrov
Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.
Journal of hypertension 2004;22(2):389-97.
2004: ANGELO SCUTERI; Teri A Manolio; Emily K Marino; Alice M Arnold; Edward G Lakatta
Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131).
Journal of the American College of Cardiology 2004;43(2):187-93.
2003: ANGELO SCUTERI; Edward G Lakatta; David E Anderson; Jerome L Fleg
Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal women.
Journal of hypertension 2003;21(12):2419-20.
2003: Scott S Wildman; Kimberly M Hooper; Clare M Turner; James Sham; Edward G Lakatta; Brian F King; Robert J Unwin; Michael Sutters
The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry.
American journal of physiology. Renal physiology 2003;285(6):F1168-78.
2003: Chanil Moon; Melissa Krawczyk; Dongchoon Ahn; Ismayil Ahmet; Doojin Paik; Edward G Lakatta; Mark I Talan
Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11612-7.
2003: Rui-Ping Xiao; Sheng-Jun Zhang; Khalid Chakir; Pavel Avdonin; Weizhong Zhu; Richard A Bond; C William Balke; Edward G Lakatta; Heping Cheng
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Circulation 2003;108(13):1633-9.
2003: ANGELO SCUTERI; Markus C Stuehlinger; john cooke; Jeanette G Wright; Edward G Lakatta; David E Anderson; Jerome L Fleg
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women.
Journal of hypertension 2003;21(7):1339-46.
2003: Mingyi Wang; Gen Takagi; Kuniya Asai; Ranilo G Resuello; Filipinas F Natividad; Dorothy E Vatner; Stephen F Vatner; Edward G Lakatta
Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates.
Hypertension 2003;41(6):1308-16.
2003: Patrick McConville; Kenneth W Fishbein; Edward G Lakatta; RICHARD SPENCER
Differences in the bioenergetic response of the isolated perfused rat heart to selective beta1- and beta2-adrenergic receptor stimulation.
Circulation 2003;107(16):2146-52.
2003: K Shivakumar; David E Dostal; Kenneth R Boheler; Kenneth M Baker; Edward G Lakatta
Differential response of cardiac fibroblasts from young adult and senescent rats to ANG II.
American journal of physiology. Heart and circulatory physiology 2003;284(4):H1454-9.
2003: Kenneth R Boheler; Maria Volkova; Christopher Morrell; Rahul Garg; Yi Zhu; Kenneth Margulies; Anne-Marie Seymour; Edward G Lakatta
Sex- and age-dependent human transcriptome variability: implications for chronic heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2754-9.
2003: Olga V Fedorova; Mark I Talan; Natalia I Agalakova; Marie-Therese Droy-Lefaix; Edward G Lakatta; Alexei Y Bagrov
Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension.
Hypertension 2003;41(3):505-11.
2003: Edward G Lakatta; Victor A Maltsev; Konstantin Y Bogdanov; Michael D Stern; Tatiana M Vinogradova
Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance.
Circulation research 2003;92(3):e45-50.
2003: Edward G Lakatta
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging.
Circulation 2003;107(3):490-7.
2003: Edward G Lakatta; Daniel Levy
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.
Circulation 2003;107(2):346-54.
2003: Edward G Lakatta; Daniel Levy
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.
Circulation 2003;107(1):139-46.
2002: Paul S Hees; Jerome L Fleg; Edward G Lakatta; Edward P Shapiro
Left ventricular remodeling with age in normal men versus women: novel insights using three-dimensional magnetic resonance imaging.
The American journal of cardiology 2002;90(11):1231-6.
2002: Edward G Lakatta; STEVEN SOLLOTT
The "heartbreak" of older age.
Molecular interventions 2002;2(7):431-46.
2002: Ira R Josephson; Antonio Guia; Edward G Lakatta; Michael D Stern
Modulation of the conductance of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions.
Biophysical journal 2002;83(5):2587-94.
2002: Ira R Josephson; Antonio Guia; Edward G Lakatta; Michael D Stern
Modulation of the gating of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions.
Biophysical journal 2002;83(5):2575-86.
2002: Luis C L Correia; Edward G Lakatta; Frances C O'Connor; Lewis C Becker; Jon Clulow; Susan Townsend; Gary Gerstenblith; Jerome L Fleg
Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects.
Journal of the American College of Cardiology 2002;40(7):1290-7.
2002: Shi Qiang Wang; Edward G Lakatta; Heping Cheng; Zeng Quan Zhou
Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators.
The Journal of experimental biology 2002;205(Pt 19):2957-62.
2002: Catherine Lavoie; Jean-François Mercier; Ali Salahpour; Dhiviya Umapathy; Andreas Breit; Louis Villeneuve; Wei-Zhong Zhu; Rui-Ping Xiao; Edward G Lakatta; Michel Bouvier; Terence E Hébert
Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.
The Journal of biological chemistry 2002;277(38):35402-10.
2002: Edward G Lakatta; Tatiana M Vinogradova; Konstantin Y Bogdanov
Beta-adrenergic stimulation modulation of heart rate via synchronization of ryanodine receptor Ca2+ release.
Journal of cardiac surgery 2002;17(5):451-61.
2002: Tatiana M Vinogradova; Konstantin Y Bogdanov; Edward G Lakatta
Novel perspectives on the beating rate of the heart.
Circulation research 2002;91(4):e3.
2002: Sergey V Anisimov; Kirill V Tarasov; Michael D Stern; Edward G Lakatta; Kenneth R Boheler
A quantitative and validated SAGE transcriptome reference for adult mouse heart.
Genomics 2002;80(2):213-22.
2002: Edward G Lakatta; STEVEN SOLLOTT
Perspectives on mammalian cardiovascular aging: humans to molecules.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2002;132(4):699-721.
2002: Huang-Tian Yang; David Tweedie; Su Wang; Antonio Guia; Tatiana M Vinogradova; Konstantin Y Bogdanov; Paul D Allen; Michael D Stern; Edward G Lakatta; Kenneth R Boheler
The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9225-30.
2002: Shi-Qiang Wang; Long-Sheng Song; Le Xu; Gerhard Meissner; Edward G Lakatta; Eduardo Ríos; Michael D Stern; Heping Cheng
Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks.
Biophysical journal 2002;83(1):242-51.
2002: Andrzej M Janczewski; Harold A Spurgeon; Edward G Lakatta
Action potential prolongation in cardiac myocytes of old rats is an adaptation to sustain youthful intracellular Ca2+ regulation.
Journal of molecular and cellular cardiology 2002;34(6):641-8.
2002: Alexander I Fridman; Sergei A Matveev; Natalia I Agalakova; Olga V Fedorova; Edward G Lakatta; Alexei Y Bagrov
Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.
Journal of hypertension 2002;20(6):1189-94.
2002: Mingyi Wang; Edward G Lakatta
Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging.
Hypertension 2002;39(4):865-73.
2002: Olga V Fedorova; Mark I Talan; Natalia I Agalakova; Edward G Lakatta; Alexei Y Bagrov
Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension.
Circulation 2002;105(9):1122-7.
2002: Ira R Josephson; Antonio Guia; Michael D Stern; Edward G Lakatta
Alterations in properties of L-type Ca channels in aging rat heart.
Journal of molecular and cellular cardiology 2002;34(3):297-308.
2002: Long-Sheng Song; Antonio Guia; James N Muth; Marta Rubio; Shi-Qiang Wang; Rui-Ping Xiao; Ira R Josephson; Edward G Lakatta; Arnold Schwartz; Heping Cheng
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Circulation research 2002;90(2):174-81.
2002: Olga V Fedorova; Natalia A Dorofeeva; Denis A Lopatin; Edward G Lakatta; Alexei Y Bagrov
Phorbol diacetate potentiates na(+)-k(+) ATPase inhibition by a putative endogenous ligand, marinobufagenin.
Hypertension 2002;39(2):298-302.
2002: Tatiana M Vinogradova; Konstantin Y Bogdanov; Edward G Lakatta
beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells.
Circulation research 2002;90(1):73-9.
2002: Edward G Lakatta
Cardiovascular ageing in health sets the stage for cardiovascular disease.
Heart, lung & circulation 2002;11(2):76-91.
2002: Rachel H Mackey; Kim Sutton-Tyrrell; Peter Vietas Vaitkevicius; Pamela A Sakkinen; Mary F Lyles; Harold A Spurgeon; Edward G Lakatta; Lewis H Kuller
Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study.
American journal of hypertension 2002;15(1 Pt 1):16-23.
2002: Edward G Lakatta
Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons.
Heart failure reviews 2002;7(1):29-49.
2002: Edward G Lakatta
Introduction: chronic heart failure in older persons.
Heart failure reviews 2002;7(1):5-8.
2001: ANGELO SCUTERI; C H Chen; F C Yin; T Chih-Tai; Harold A Spurgeon; Edward G Lakatta
Functional correlates of central arterial geometric phenotypes.
Hypertension 2001;38(6):1471-5.
2001: Michael Neuss; Michael T Crow; Alan Chesley; Edward G Lakatta
Apoptosis in cardiac disease--what is it--how does it occur.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2001;15(6):507-23.
2001: David A Kass; Edward P Shapiro; Miho Kawaguchi; Anne Capriotti; ANGELO SCUTERI; R C deGroof; Edward G Lakatta
Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.
Circulation 2001;104(13):1464-70.
2001: Kim Sutton-Tyrrell; Anne Newman; Eleanor M Simonsick; R Havlik; Marco Pahor; Edward G Lakatta; Harold A Spurgeon; Peter Vietas Vaitkevicius
Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition.
Hypertension 2001;38(3):429-33.
2001: Olga V Fedorova; David E Anderson; Edward G Lakatta; Alexei Y Bagrov
Interaction of NaCl and behavioral stress on endogenous sodium pump ligands in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(1):R352-8.
2001: Konstantin Y Bogdanov; Tatiana M Vinogradova; Edward G Lakatta
Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation.
Circulation research 2001;88(12):1254-8.
2001: Sergey V Anisimov; Edward G Lakatta; Kenneth R Boheler
Discovering altered genomic expression patterns in heart: transcriptome determination by serial analysis of gene expression.
European journal of heart failure 2001;3(3):271-81.
2001: Antonio Guia; Michael D Stern; Edward G Lakatta; Ira R Josephson
Ion concentration-dependence of rat cardiac unitary L-type calcium channel conductance.
Biophysical journal 2001;80(6):2742-50.
2001: Alan Heldman; Linda Cheng; G M Jenkins; P F Heller; D W Kim; M Ware; C Nater; Ralph Hruban; B Rezai; B S Abella; K E Bunge; JL Kinsella; STEVEN SOLLOTT; Edward G Lakatta; Jeffrey A Brinker; W L Hunter; Jeffrey P Froehlich
Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis.
Circulation 2001;103(18):2289-95.
2001: Kim Sutton-Tyrrell; Rachel H Mackey; Richard Holubkov; Peter Vietas Vaitkevicius; Harold A Spurgeon; Edward G Lakatta
Measurement variation of aortic pulse wave velocity in the elderly.
American journal of hypertension 2001;14(5 Pt 1):463-8.
2001: Long-Sheng Song; Shi-Qiang Wang; Rui-Ping Xiao; Harold A Spurgeon; Edward G Lakatta; Heping Cheng
beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes.
Circulation research 2001;88(8):794-801.
2001: ANGELO SCUTERI; Edward G Lakatta; Angelo J G Bos; Jerome L Fleg
Effect of estrogen and progestin replacement on arterial stiffness indices in postmenopausal women.
Aging (Milan, Italy) 2001;13(2):122-30.
2001: Shi-Qiang Wang; Long-Sheng Song; Edward G Lakatta; Heping Cheng
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells.
Nature 2001;410(6828):592-6.
2001: Olga V Fedorova; Nikolai I Kolodkin; Natalia I Agalakova; Edward G Lakatta; Alexei Y Bagrov
Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats.
Hypertension 2001;37(2 Pt 2):462-6.
2001: Peter Vietas Vaitkevicius; M Lane; Harold A Spurgeon; Donald Ingram; George S Roth; J J Egan; S Vasan; DR Wagle; PC Ulrich; Michael Brines; J P Wuerth; Anthony Cerami; Edward G Lakatta
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1171-5.
2001: Edward G Lakatta; STEVEN SOLLOTT; Salvatore Pepe
The old heart: operating on the edge.
Novartis Foundation symposium 2001;235():172-96; discussion 196-201, 217-20.
2001: ANGELO SCUTERI; Angelo J G Bos; Alan B Zonderman; Larry J Brant; Edward G Lakatta; Jerome L Fleg
Is the apoE4 allele an independent predictor of coronary events?
The American journal of medicine 2001;110(1):28-32.
2001: Richard J Havlik; D Brock; K Lohman; W Haskell; Peter Snell; M O'Toole; P Ribisl; Peter Vietas Vaitkevicius; Harold A Spurgeon; Edward G Lakatta; P Pullen
High-density lipoprotein cholesterol and vascular stiffness at baseline in the activity counseling trial.
The American journal of cardiology 2001;87(1):104-7, A9.
2000: Olga V Fedorova; Edward G Lakatta; Alexei Y Bagrov
Endogenous Na,K pump ligands are differentially regulated during acute NaCl loading of Dahl rats.
Circulation 2000;102(24):3009-14.
2000: Alan Chesley; MS Lundberg; T Asai; Rui-Ping Xiao; S Ohtani; Edward G Lakatta; Michael T Crow
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase.
Circulation research 2000;87(12):1172-9.
2000: Ye Chen-Izu; Rui-Ping Xiao; Leighton Izu; Heping Cheng; Meike Kuschel; Harold A Spurgeon; Edward G Lakatta
G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.
Biophysical journal 2000;79(5):2547-56.
2000: Ying-Ying Zhou; Dongmei Yang; Wei-Zhong Zhu; Sheng-Jun Zhang; D J Wang; Daniel K Rohrer; E Devic; Brian K Kobilka; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice.
Molecular pharmacology 2000;58(5):887-94.
2000: Andrzej M Janczewski; Edward G Lakatta; Michael D Stern
Voltage-independent changes in L-type Ca(2+) current uncoupled from SR Ca(2+) release in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H2024-31.
2000: A Younès; Salvatore Pepe; BA Barron; Harold A Spurgeon; Edward G Lakatta; James L Caffrey
Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1989-98.
2000: Z Li; C Nater; J Kinsella; Francis J Chrest; Edward G Lakatta
Minoxidil inhibits proliferation and migration of cultured vascular smooth muscle cells and neointimal formation after balloon catheter injury.
Journal of cardiovascular pharmacology 2000;36(2):270-6.
2000: L H Gowdak; L Poliakova; X Wang; Imre Kovesdi; Kenneth W Fishbein; Antonella Zacheo; Roberta Palumbo; Stefania Straino; Costanza Emanueli; M Marrocco-Trischitta; Edward G Lakatta; Piero Anversa; RICHARD SPENCER; Mark I Talan; Maurizio C Capogrossi
Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia.
Circulation 2000;102(5):565-71.
2000: Edward G Lakatta
Cardiovascular aging in health.
Clinics in geriatric medicine 2000;16(3):419-44.
2000: L H Gowdak; L Poliakova; Z Li; R Grove; Edward G Lakatta; Mark I Talan
Induction of angiogenesis by cationic lipid-mediated VEGF165 gene transfer in the rabbit ischemic hindlimb model.
Journal of vascular surgery 2000;32(2):343-52.
2000: Sheng-Jun Zhang; Heping Cheng; Ying-Ying Zhou; D J Wang; Weizhong Zhu; Bruce D Ziman; H Spurgoen; RJ Lefkowitz; Edward G Lakatta; Walter J Koch; Rui-Ping Xiao
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
2000: Ying-Ying Zhou; Shi-Qiang Wang; Wei-Zhong Zhu; AJ Chruscinski; Brian K Kobilka; Bruce D Ziman; Su Wang; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H429-36.
2000: Alexei Y Bagrov; Renata I Dmitrieva; N A Dorofeeva; Olga V Fedorova; Denis A Lopatin; Edward G Lakatta; Marie-Therese Droy-Lefaix
Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism.
Journal of hypertension 2000;18(2):209-15.
1999: Ying-Ying Zhou; Long-Sheng Song; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
The Journal of physiology 1999;521 Pt 2():351-61.
1999: Rui-Ping Xiao; Heping Cheng; Ying-Ying Zhou; Meike Kuschel; Edward G Lakatta
Recent advances in cardiac beta(2)-adrenergic signal transduction.
Circulation research 1999;85(11):1092-100.
1999: A Nussbacher; Gary Gerstenblith; Frances C O'Connor; Lewis C Becker; David A Kass; Steven P Schulman; Jerome L Fleg; Edward G Lakatta
Hemodynamic effects of unloading the old heart.
The American journal of physiology 1999;277(5 Pt 2):H1863-71.
1999: Ying-Ying Zhou; Heping Cheng; Long-Sheng Song; D Wang; Edward G Lakatta; Rui-Ping Xiao
Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes.
Molecular pharmacology 1999;56(3):485-93.
1999: Rakesh K Srivastava; STEVEN SOLLOTT; L Khan; Richard G Hansford; Edward G Lakatta; Dan Longo
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis.
Molecular and cellular biology 1999;19(8):5659-74.
1999: Meike Kuschel; Ying-Ying Zhou; Heping Cheng; Sheng-Jun Zhang; Ye Chen-Izu; Edward G Lakatta; Rui-Ping Xiao
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
The Journal of biological chemistry 1999;274(31):22048-52.
1999: James N Muth; Hiroshi Yamaguchi; Gábor Mikala; Ingrid L Grupp; William Lewis; Heping Cheng; Long-Sheng Song; Edward G Lakatta; Gyula Varadi; Arnold Schwartz
Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction.
The Journal of biological chemistry 1999;274(31):21503-6.
1999: Martín G Vila Petroff; A Younes; J Egan; Edward G Lakatta; STEVEN SOLLOTT
Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes.
Circulation research 1999;84(9):1020-31.
1999: Meike Kuschel; Ying-Ying Zhou; Harold A Spurgeon; Sabine Bartel; Peter Karczewski; Sheng-Jun Zhang; Ernst-Georg Krause; Edward G Lakatta; Rui-Ping Xiao
beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart.
Circulation 1999;99(18):2458-65.
1999: Edward G Lakatta
Cardiovascular aging research: the next horizons.
Journal of the American Geriatrics Society 1999;47(5):613-25.
1999: Heping Cheng; Long-Sheng Song; Natalia Shirokova; Adom González; Edward G Lakatta; Eduardo Ríos; Michael D Stern
Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method.
Biophysical journal 1999;76(2):606-17.
1999: Rui-Ping Xiao; Pavel Avdonin; Ying-Ying Zhou; Heping Cheng; S A Akhter; T Eschenhagen; RJ Lefkowitz; Walter J Koch; Edward G Lakatta
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Circulation research 1999;84(1):43-52.
1999: X Long; Marvin O Boluyt; L O'Neill; JS Zheng; G Wu; Y K Nitta; Michael T Crow; Edward G Lakatta
Myocardial retinoid X receptor, thyroid hormone receptor, and myosin heavy chain gene expression in the rat during adult aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 1999;54(1):B23-7.
1999: Z Li; James B Froehlich; Zorina Galis; Edward G Lakatta
Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats.
Hypertension 1999;33(1):116-23.
1999: Salvatore Pepe; N Tsuchiya; Edward G Lakatta; Richard G Hansford
PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH.
The American journal of physiology 1999;276(1 Pt 2):H149-58.
1998: James Sham; Long-Sheng Song; Ye Chen-Izu; L H Deng; Michael D Stern; Edward G Lakatta; Heping Cheng
Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):15096-101.
1998: Alexandre Mebazaa; R C Wetzel; Jeffrey M Dodd-o; E M Redmond; Ajay M Shah; K Maeda; Geneviève Maistre; Edward G Lakatta; JL Robotham
Potential paracrine role of the pericardium in the regulation of cardiac function.
Cardiovascular research 1998;40(2):332-42.
1998: Long-Sheng Song; James Sham; Michael D Stern; Edward G Lakatta; Heping Cheng
Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes.
The Journal of physiology 1998;512 ( Pt 3)():677-91.
1998: Yoji Nagai; E Jeffrey Metter; Christopher J Earley; MK Kemper; Lewis C Becker; Edward G Lakatta; Jerome L Fleg
Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia.
Circulation 1998;98(15):1504-9.
1998: C H Chen; C T Ting; S J Lin; Tsui-Lieh Hsu; S J Ho; P Chou; Mau-Song Chang; F O'Connor; Harold A Spurgeon; Edward G Lakatta; F C Yin
Which arterial and cardiac parameters best predict left ventricular mass?
Circulation 1998;98(5):422-8.
1998: Ying-Ying Zhou; Edward G Lakatta; Rui-Ping Xiao
Age-associated alterations in calcium current and its modulation in cardiac myocytes.
Drugs & aging 1998;13(2):159-71.
1998: Ajay M Shah; STEVEN SOLLOTT; Edward G Lakatta
Physio-pharmacological evaluation of myocardial performance: an integrative approach.
Cardiovascular research 1998;39(1):148-54.
1998: G Gambassi; Harold A Spurgeon; Bruce D Ziman; Edward G Lakatta; M C Capogrossi
Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes.
The American journal of physiology 1998;274(4 Pt 2):H1152-62.
1998: X Long; Michael T Crow; STEVEN SOLLOTT; L O'Neill; D S Menees; M de Lourdes Hipolito; Marvin O Boluyt; T Asai; Edward G Lakatta
Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes.
The Journal of clinical investigation 1998;101(6):1453-61.
1998: Rui-Ping Xiao; E D Tomhave; D J Wang; X Ji; Marvin O Boluyt; Heping Cheng; Edward G Lakatta; Walter J Koch
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation 1998;101(6):1273-82.
1998: JS Zheng; L O'Neill; X Long; TE Webb; E A Barnard; Edward G Lakatta; Marvin O Boluyt
Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts.
Cardiovascular research 1998;37(3):718-28.
1998: Konstantin Y Bogdanov; Harold A Spurgeon; T M Vinogradova; Edward G Lakatta
Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids.
The American journal of physiology 1998;274(2 Pt 2):H571-9.
1998: G M Jenkins; Michael T Crow; C Bilato; Yehezkiel A Gluzband; W S Ryu; Z Li; W Stetler-Stevenson; C Nater; Jeffrey P Froehlich; Edward G Lakatta; Linda Cheng
Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries.
Circulation 1998;97(1):82-90.
1997: Long-Sheng Song; Michael D Stern; Edward G Lakatta; Heping Cheng
Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes.
The Journal of physiology 1997;505 ( Pt 3)():665-75.
1997: Wesley W Brooks; Oscar H L Bing; Chester H Conrad; L O'Neill; Michael T Crow; Edward G Lakatta; David E Dostal; Kenneth M Baker; Marvin O Boluyt
Captopril modifies gene expression in hypertrophied and failing hearts of aged spontaneously hypertensive rats.
Hypertension 1997;30(6):1362-8.
1997: Ying-Ying Zhou; Heping Cheng; Konstantin Y Bogdanov; C Hohl; Ruth A Altschuld; Edward G Lakatta; Rui-Ping Xiao
Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling.
The American journal of physiology 1997;273(3 Pt 2):H1611-8.
1997: Marvin O Boluyt; JS Zheng; A Younes; X Long; L O'Neill; H Silverman; Edward G Lakatta; Michael T Crow
Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase.
Circulation research 1997;81(2):176-86.
1997: X Long; Marvin O Boluyt; M L Hipolito; MS Lundberg; JS Zheng; L O'Neill; corrado cirielli; Edward G Lakatta; Michael T Crow
p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.
The Journal of clinical investigation 1997;99(11):2635-43.
1997: Z Li; Oscar H L Bing; X Long; Kathleen G Robinson; Edward G Lakatta
Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat.
The American journal of physiology 1997;272(5 Pt 2):H2313-9.
1997: Ajay M Shah; Alexandre Mebazaa; Zhao-Kang Yang; Giovanni Cuda; E B Lankford; C B Pepper; STEVEN SOLLOTT; James R Sellers; JL Robotham; Edward G Lakatta
Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand?
Circulation research 1997;80(5):688-98.
1997: Rui-Ping Xiao; Héctor H Valdivia; Konstantin Y Bogdanov; C Valdivia; Edward G Lakatta; Heping Cheng
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.
The Journal of physiology 1997;500 ( Pt 2)():343-54.
1997: Salvatore Pepe; Rui-Ping Xiao; C Hohl; Ruth A Altschuld; Edward G Lakatta
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
Circulation 1997;95(8):2122-9.
1997: Jeffrey M Dodd-o; G Zheng; H S Silverman; Edward G Lakatta; Roy C Ziegelstein
Endothelium-independent relaxation of aortic rings by the nitric oxide synthase inhibitor diphenyleneiodonium.
British journal of pharmacology 1997;120(5):857-64.
1997: Z Li; Heping Cheng; William Lederer; James B Froehlich; Edward G Lakatta
Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants.
Experimental and molecular pathology 1997;64(1):1-11.
1997: Rui-Ping Xiao; Salvatore Pepe; Harold A Spurgeon; M C Capogrossi; Edward G Lakatta
Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.
The American journal of physiology 1997;272(2 Pt 2):H797-805.
1997: D H Korzick; Rui-Ping Xiao; Bruce D Ziman; Walter J Koch; RJ Lefkowitz; Edward G Lakatta
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
The American journal of physiology 1997;272(1 Pt 2):H590-6.
1997: Y Miyashita; STEVEN SOLLOTT; Linda Cheng; JL Kinsella; E Koh; Edward G Lakatta; Jeffrey P Froehlich
Redistribution of intracellular Ca2+ stores after beta-adrenergic stimulation of rat tail artery SMC.
The American journal of physiology 1997;272(1 Pt 2):H244-55.
1996: STEVEN SOLLOTT; Bruce D Ziman; D M Warshaw; Harold A Spurgeon; Edward G Lakatta
Actomyosin interaction modulates resting length of unstimulated cardiac ventricular cells.
The American journal of physiology 1996;271(3 Pt 2):H896-905.
1996: Heping Cheng; M R Lederer; Rui-Ping Xiao; Ana Gomez; Ying-Ying Zhou; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta; William Lederer
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
Cell calcium 1996;20(2):129-40.
1996: Steven P Schulman; Jerome L Fleg; Andrew P Goldberg; Jan Busby-Whitehead; James M. Hagberg; Frances C O'Connor; Gary Gerstenblith; Lewis C Becker; Leslie I Katzel; L E Lakatta; Edward G Lakatta
Continuum of cardiovascular performance across a broad range of fitness levels in healthy older men.
Circulation 1996;94(3):359-67.
1996: JS Zheng; Marvin O Boluyt; X Long; L O'Neill; Edward G Lakatta; Michael T Crow
Extracellular ATP inhibits adrenergic agonist-induced hypertrophy of neonatal cardiac myocytes.
Circulation research 1996;78(4):525-35.
1996: Z Li; Ling Li; H Ronald Zielke; Linda Cheng; R Xiao; Michael T Crow; William Stetler-Stevenson; James B Froehlich; Edward G Lakatta
Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions.
The American journal of pathology 1996;148(1):121-8.
1995: Konstantin Y Bogdanov; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta
L- and T-type calcium currents differ in finch and rat ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 1995;27(12):2581-93.
1995: Marvin O Boluyt; Oscar H L Bing; Edward G Lakatta
The ageing spontaneously hypertensive rat as a model of the transition from stable compensated hypertrophy to heart failure.
European heart journal 1995;16 Suppl N():19-30.
1995: stefano corda; Harold A Spurgeon; Edward G Lakatta; Maurizio C Capogrossi; Roy C Ziegelstein
Endoplasmic reticulum Ca2+ depletion unmasks a caffeine-induced Ca2+ influx in human aortic endothelial cells.
Circulation research 1995;77(5):927-35.
1995: O Hano; Konstantin Y Bogdanov; M Sakai; R G Danziger; Harold A Spurgeon; Edward G Lakatta
Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging.
The American journal of physiology 1995;269(5 Pt 2):H1607-12.
1995: C Bilato; R R Pauly; G Melillo; Robert Monticone; D Gorelick-Feldman; Yehezkiel A Gluzband; STEVEN SOLLOTT; Bruce D Ziman; Edward G Lakatta; Michael T Crow
Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.
The Journal of clinical investigation 1995;96(4):1905-15.
1995: A Younes; Marvin O Boluyt; L O'Neill; Andrea L Meredith; Michael T Crow; Edward G Lakatta
Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy.
The American journal of physiology 1995;269(3 Pt 2):H1003-8.
1995: Marvin O Boluyt; X Long; Thomas Eschenhagen; U Mende; W Schmitz; Michael T Crow; Edward G Lakatta
Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart.
The American journal of physiology 1995;269(2 Pt 2):H638-47.
1995: Ajay M Shah; HS Silverman; Elinor J Griffiths; Harold A Spurgeon; Edward G Lakatta
cGMP prevents delayed relaxation at reoxygenation after brief hypoxia in isolated cardiac myocytes.
The American journal of physiology 1995;268(6 Pt 2):H2396-204.
1995: Jerome L Fleg; Edward P Shapiro; Frances C O'Connor; J Taube; Andrew P Goldberg; Edward G Lakatta
Left ventricular diastolic filling performance in older male athletes.
JAMA : the journal of the American Medical Association 1995;273(17):1371-5.
1995: STEVEN SOLLOTT; Linda Cheng; R R Pauly; G M Jenkins; Robert Monticone; M Kuzuya; Jeffrey P Froehlich; Michael T Crow; Edward G Lakatta; eric rowinsky
Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat.
The Journal of clinical investigation 1995;95(4):1869-76.
1995: Jerome L Fleg; Frances C O'Connor; Gary Gerstenblith; Lewis C Becker; J Clulow; Steven P Schulman; Edward G Lakatta
Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):890-900.
1995: R R Pauly; C Bilato; STEVEN SOLLOTT; Robert Monticone; P T Kelly; Edward G Lakatta; Michael T Crow
Role of calcium/calmodulin-dependent protein kinase II in the regulation of vascular smooth muscle cell migration.
Circulation 1995;91(4):1107-15.
1995: Rui-Ping Xiao; X Ji; Edward G Lakatta
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
Molecular pharmacology 1995;47(2):322-9.
1995: Andrzej M Janczewski; Harold A Spurgeon; Michael D Stern; Edward G Lakatta
Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells.
The American journal of physiology 1995;268(2 Pt 2):H916-20.
1994: Leslie I Katzel; K D Sorkin; E Colman; Andrew P Goldberg; MJ Busby-Whitehead; L E Lakatta; Lewis C Becker; Edward G Lakatta; Jerome L Fleg
Risk factors for exercise-induced silent myocardial ischemia in healthy volunteers.
The American journal of cardiology 1994;74(9):869-74.
1994: Rui-Ping Xiao; Harold A Spurgeon; F O'Connor; Edward G Lakatta
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
The Journal of clinical investigation 1994;94(5):2051-9.
1994: Jerome L Fleg; Steven P Schulman; Frances C O'Connor; Lewis C Becker; Gary Gerstenblith; J F Clulow; D G Renlund; Edward G Lakatta
Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.
Circulation 1994;90(5):2333-41.
1994: STEVEN SOLLOTT; Edward G Lakatta
Novel method to alter length and load in isolated mammalian cardiac myocytes.
The American journal of physiology 1994;267(4 Pt 2):H1619-29.
1994: R P Xiao; Heping Cheng; William Lederer; T Suzuki; Edward G Lakatta
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9659-63.
1994: Salvatore Pepe; Konstantin Y Bogdanov; H Hallaq; Harold A Spurgeon; Alexander Leaf; Edward G Lakatta
Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8832-6.
1994: Roy C Ziegelstein; Linda Cheng; THOMAS AVERSANO; Pamela Ouyang; Edward G Lakatta; HS Silverman
Increase in rat aortic endothelial free calcium mediated by metabolically sensitive calcium release from endoplasmic reticulum.
Cardiovascular research 1994;28(9):1433-9.
1994: Jerome L Fleg; Steven P Schulman; Frances C O'Connor; Gary Gerstenblith; Lewis C Becker; S Fortney; Andrew P Goldberg; Edward G Lakatta
Cardiovascular responses to exhaustive upright cycle exercise in highly trained older men.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;77(3):1500-6.
1994: Frances C O'Connor; Jerome L Fleg; Gary Gerstenblith; Lewis C Becker; Andrew P Goldberg; James M. Hagberg; L Lakatta; Edward G Lakatta; Steven P Schulman
Effect of body fat on exercise hemodynamics in sedentary older men.
Aging (Milan, Italy) 1994;6(4):257-65.
1994: Edward G Lakatta
Cardiovascular reserve capacity in healthy older humans.
Aging (Milan, Italy) 1994;6(4):213-23.
1994: Rui-Ping Xiao; CM Hohl; Ruth A Altschuld; L Jones; B Livingston; Bruce D Ziman; B Tantini; Edward G Lakatta
Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.
The Journal of biological chemistry 1994;269(29):19151-6.
1994: Mark C P Haigney; Edward G Lakatta; Michael D Stern; HS Silverman
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Circulation 1994;90(1):391-9.
1994: R R Pauly; Antonino Passaniti; C Bilato; Robert Monticone; Linda Cheng; N Papadopoulos; Yehezkiel A Gluzband; L Smith; C Weinstein; Edward G Lakatta
Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation.
Circulation research 1994;75(1):41-54.
1994: Marvin O Boluyt; L O'Neill; Andrea L Meredith; Oscar H L Bing; Wesley W Brooks; Chester H Conrad; Michael T Crow; Edward G Lakatta
Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.
Circulation research 1994;75(1):23-32.
1994: Ajay M Shah; Alexandre Mebazaa; R C Wetzel; Edward G Lakatta
Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells.
Circulation 1994;89(6):2492-7.
1994: JS Zheng; Marvin O Boluyt; L O'Neill; Michael T Crow; Edward G Lakatta
Extracellular ATP induces immediate-early gene expression but not cellular hypertrophy in neonatal cardiac myocytes.
Circulation research 1994;74(6):1034-41.
1994: James L Caffrey; Marvin O Boluyt; A Younes; B A Barron; L O'Neill; Michael T Crow; Edward G Lakatta
Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat.
Journal of molecular and cellular cardiology 1994;26(6):701-11.
1994: O Hano; S L Thompson-Gorman; Jay L Zweier; Edward G Lakatta
Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion.
The American journal of physiology 1994;266(6 Pt 2):H2174-81.
1994: Ajay M Shah; Harold A Spurgeon; STEVEN SOLLOTT; A Talo; Edward G Lakatta
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Circulation research 1994;74(5):970-8.
1994: HS Silverman; Fabio Di Lisa; R C Hui; H Miyata; STEVEN SOLLOTT; R G Hanford; Edward G Lakatta; Michael D Stern
Regulation of intracellular free Mg2+ and contraction in single adult mammalian cardiac myocytes.
The American journal of physiology 1994;266(1 Pt 1):C222-33.
1994: Roy C Ziegelstein; Harold A Spurgeon; Roberto Pili; Antonino Passaniti; Linda Cheng; stefano corda; Edward G Lakatta; Maurizio C Capogrossi
A functional ryanodine-sensitive intracellular Ca2+ store is present in vascular endothelial cells.
Circulation research 1994;74(1):151-6.
1993: R John Solaro; G Gambassi; D M Warshaw; M R Keller; Harold A Spurgeon; N Beier; Edward G Lakatta
Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments.
Circulation research 1993;73(6):981-90.
1993: Alexandre Mebazaa; E Mayoux; K Maeda; Lynn D Martin; Edward G Lakatta; JL Robotham; Ajay M Shah
Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin.
The American journal of physiology 1993;265(5 Pt 2):H1841-6.
1993: Andrzej M Janczewski; Edward G Lakatta
Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes.
The Journal of physiology 1993;471():343-63.
1993: Peter Vietas Vaitkevicius; Jerome L Fleg; J H Engel; Frances C O'Connor; Jeanette G Wright; L E Lakatta; F C Yin; Edward G Lakatta
Effects of age and aerobic capacity on arterial stiffness in healthy adults.
Circulation 1993;88(4 Pt 1):1456-62.
1993: Roy C Ziegelstein; Linda Cheng; P S Blank; Harold A Spurgeon; Edward G Lakatta; Richard G Hansford; Maurizio C Capogrossi
Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification.
The American journal of physiology 1993;265(4 Pt 2):H1424-33.
1993: G Gambassi; Richard G Hansford; STEVEN SOLLOTT; Barbara A Hogue; Edward G Lakatta; Maurizio C Capogrossi
Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium.
The Journal of general physiology 1993;102(3):575-97.
1993: William H duBell; Bohdan Lewartowski; Harold A Spurgeon; HS Silverman; Edward G Lakatta
Repletion of sarcoplasmic reticulum Ca after ryanodine in rat ventricular myocytes.
The American journal of physiology 1993;265(2 Pt 2):H604-15.
1993: Andrzej M Janczewski; Edward G Lakatta
Thapsigargin inhibits Ca2+ uptake, and Ca2+ depletes sarcoplasmic reticulum in intact cardiac myocytes.
The American journal of physiology 1993;265(2 Pt 2):H517-22.
1993: Edward G Lakatta; T Guarnieri
Spontaneous myocardial calcium oscillations: are they linked to ventricular fibrillation?
Journal of cardiovascular electrophysiology 1993;4(4):473-89.
1993: Jerome L Fleg; Steven P Schulman; Gary Gerstenblith; Lewis C Becker; Frances C O'Connor; Edward G Lakatta
Additive effects of age and silent myocardial ischemia on the left ventricular response to upright cycle exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(2):499-504.
1993: Rui-Ping Xiao; Edward G Lakatta
Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.
Circulation research 1993;73(2):286-300.
1993: Marvin O Boluyt; A Younes; James L Caffrey; L O'Neill; B A Barron; Michael T Crow; Edward G Lakatta
Age-associated increase in rat cardiac opioid production.
The American journal of physiology 1993;265(1 Pt 2):H212-8.
1993: Rui-Ping Xiao; Harold A Spurgeon; Maurizio C Capogrossi; Edward G Lakatta
Stimulation of opioid receptors on cardiac ventricular myocytes reduces L type Ca2+ channel current.
Journal of molecular and cellular cardiology 1993;25(6):661-6.
1993: Edward G Lakatta
Cardiovascular regulatory mechanisms in advanced age.
Physiological reviews 1993;73(2):413-67.
1993: Francis J Chrest; R R Pauly; Robert Monticone; Edward G Lakatta; W H Adler
TGF beta-1 receptor expression and cell cycle analysis of vascular smooth muscle cells from young and aged rats.
Annals of the New York Academy of Sciences 1993;677():396-9.
1993: G Gambassi; Maurizio C Capogrossi; M Klockow; Edward G Lakatta
Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes.
The American journal of physiology 1993;264(3 Pt 2):H728-38.
1993: Edward G Lakatta
Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans.
Circulation 1993;87(2):631-6.
1993: Edward G Lakatta
Myocardial adaptations in advanced age.
Basic research in cardiology 1993;88 Suppl 2():125-33.
1992: Rui-Ping Xiao; Edward G Lakatta
Deterioration of beta-adrenergic modulation of cardiovascular function with aging.
Annals of the New York Academy of Sciences 1992;673():293-310.
1992: S Fortney; Clarke G Tankersley; J T Lightfoot; D Drinkwater; J Clulow; Gary Gerstenblith; Frances C O'Connor; Lewis C Becker; Edward G Lakatta; Jerome L Fleg
Cardiovascular responses to lower body negative pressure in trained and untrained older men.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(6):2693-700.
1992: Edward G Lakatta
Interaction between nutrition and aging: a summary of effects on the cardiovascular system.
Nutrition reviews 1992;50(12):419-20.
1992: Steven P Schulman; Edward G Lakatta; Jerome L Fleg; L Lakatta; Lewis C Becker; Gary Gerstenblith
Age-related decline in left ventricular filling at rest and exercise.
The American journal of physiology 1992;263(6 Pt 2):H1932-8.
1992: R R Pauly; Antonino Passaniti; Michael T Crow; J L Kinsella; N Papadopoulos; Robert Monticone; Edward G Lakatta; G R Martin
Experimental models that mimic the differentiation and dedifferentiation of vascular cells.
Circulation 1992;86(6 Suppl):III68-73.
1992: G Gambassi; Harold A Spurgeon; Edward G Lakatta; P S Blank; Maurizio C Capogrossi
Different effects of alpha- and beta-adrenergic stimulation on cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes.
Circulation research 1992;71(4):870-82.
1992: H Miyata; Edward G Lakatta; Michael D Stern; HS Silverman
Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.
Circulation research 1992;71(3):605-13.
1992: Mark C P Haigney; H Miyata; Edward G Lakatta; Michael D Stern; HS Silverman
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Circulation research 1992;71(3):547-57.
1992: P S Blank; HS Silverman; O Y Chung; Barbara A Hogue; Michael D Stern; Richard G Hansford; Edward G Lakatta; Maurizio C Capogrossi
Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphthorhodafluor-1.
The American journal of physiology 1992;263(1 Pt 2):H276-84.
1992: STEVEN SOLLOTT; Bruce D Ziman; Edward G Lakatta
Novel technique to load indo-1 free acid into single adult cardiac myocytes to assess cytosolic Ca2+.
The American journal of physiology 1992;262(6 Pt 2):H1941-9.
1992: Carlo Ventura; R Miller; H P Wolf; N Beier; R Jonas; M Klockow; I Lues; O Hano; Harold A Spurgeon; Edward G Lakatta
Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.
Circulation research 1992;70(6):1081-90.
1992: Roy C Ziegelstein; Jay L Zweier; E D Mellits; A Younes; Edward G Lakatta; Michael D Stern; HS Silverman
Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.
Circulation research 1992;70(4):804-11.
1992: Edward G Lakatta
Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart.
Cardiovascular research 1992;26(3):193-214.
1992: Harold A Spurgeon; William H duBell; Michael D Stern; STEVEN SOLLOTT; Bruce D Ziman; HS Silverman; Maurizio C Capogrossi; A Talo; Edward G Lakatta
Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation.
The Journal of physiology 1992;447():83-102.
1992: Edward K Kasper; Carlo Ventura; Bruce D Ziman; Edward G Lakatta; H Weisman; Maurizio C Capogrossi
Effect of U-50,488H on the contractile response of cardiomyopathic hamster ventricular myocytes.
Life sciences 1992;50(26):2029-35.
1992: M Sakai; Robert S Danziger; Rui-Ping Xiao; Harold A Spurgeon; Edward G Lakatta
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence.
The American journal of physiology 1992;262(1 Pt 2):H184-9.
1992: Carlo Ventura; Harold A Spurgeon; Edward G Lakatta; C Guarnieri; Maurizio C Capogrossi
Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons.
Circulation research 1992;70(1):66-81.
1992: Edward G Lakatta; A Talo; Maurizio C Capogrossi; Harold A Spurgeon; Michael D Stern
Spontaneous sarcoplasmic reticulum Ca2+ release leads to heterogeneity of contractile and electrical properties of the heart.
Basic research in cardiology 1992;87 Suppl 2():93-104.
1991: O Hano; HS Silverman; P S Blank; E D Mellits; R Baumgardner; Edward G Lakatta; Michael D Stern
Nicardipine prevents calcium loading and "oxygen paradox" in anoxic single rat myocytes by a mechanism independent of calcium channel blockade.
Circulation research 1991;69(6):1500-5.
1991: Carlo Ventura; Maurizio C Capogrossi; Harold A Spurgeon; Edward G Lakatta
Kappa-opioid peptide receptor stimulation increases cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes.
The American journal of physiology 1991;261(5 Pt 2):H1671-4.
1991: H Miyata; HS Silverman; STEVEN SOLLOTT; Edward G Lakatta; Michael D Stern; Richard G Hansford
Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes.
The American journal of physiology 1991;261(4 Pt 2):H1123-34.
1991: Carlo Ventura; Carlo Guarnieri; Claudio Stefanelli; corrado cirielli; Edward G Lakatta; Maurizio C Capogrossi
Comparison between alpha-adrenergic- and K-opioidergic-mediated inositol (1,4,5)P3/inositol (1,3,4,5) P4 formation in adult cultured rat ventricular cardiomyocytes.
Biochemical and biophysical research communications 1991;179(2):972-8.
1991: Maurizio C Capogrossi; W A Kachadorian; G Gambassi; Harold A Spurgeon; Edward G Lakatta
Ca2+ dependence of alpha-adrenergic effects on the contractile properties and Ca2+ homeostasis of cardiac myocytes.
Circulation research 1991;69(2):540-50.
1991: HS Silverman; M Ninomiya; P S Blank; O Hano; H Miyata; Harold A Spurgeon; Edward G Lakatta; Michael D Stern
A cellular mechanism for impaired posthypoxic relaxation in isolated cardiac myocytes. Altered myofilament relaxation kinetics at reoxygenation.
Circulation research 1991;69(1):196-208.
1991: O Hano; Edward G Lakatta
Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses.
Circulation research 1991;69(1):123-33.
1991: Robert S Danziger; M Sakai; Maurizio C Capogrossi; Harold A Spurgeon; Richard G Hansford; Edward G Lakatta
Ethanol acutely and reversibly suppresses excitation-contraction coupling in cardiac myocytes.
Circulation research 1991;68(6):1660-8.
1991: William H duBell; M R Boyett; Harold A Spurgeon; A Talo; Michael D Stern; Edward G Lakatta
The cytosolic calcium transient modulates the action potential of rat ventricular myocytes.
The Journal of physiology 1991;436():347-69.
1991: Steven P Schulman; Edward G Lakatta; Robert G Weiss; M R Wolff; O Hano; Gary Gerstenblith
Contractile, metabolic and electrophysiologic effects of ethanol in the isolated rat heart.
Journal of molecular and cellular cardiology 1991;23(4):417-26.
1991: L O'Neill; Nikki J Holbrook; J Fargnoli; Edward G Lakatta
Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes.
Cardioscience 1991;2(1):1-5.
1991: C Ferroni; O Hano; Carlo Ventura; Edward G Lakatta; M Klockow; Harold A Spurgeon; Maurizio C Capogrossi
A novel positive inotropic substance enhances contractility without increasing the Ca2+ transient in rat myocardium.
Journal of molecular and cellular cardiology 1991;23(3):325-31.
1991: T Kaku; Edward G Lakatta; C Filburn
Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes.
The American journal of physiology 1991;260(3 Pt 1):C635-42.
1991: R A Josephson; HS Silverman; Edward G Lakatta; Michael D Stern; Jay L Zweier
Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes.
The Journal of biological chemistry 1991;266(4):2354-61.
1991: G Gambassi; Edward G Lakatta; Maurizio C Capogrossi
[Alpha but not beta-adrenergic stimulation has a positive inotropic effect associated with alkalinization of intracellular pH].
Cardiologia (Rome, Italy) 1991;36(1):47-58.
1990: A Talo; Michael D Stern; Harold A Spurgeon; G Isenberg; Edward G Lakatta
Sustained subthreshold-for-twitch depolarization in rat single ventricular myocytes causes sustained calcium channel activation and sarcoplasmic reticulum calcium release.
The Journal of general physiology 1990;96(5):1085-103.
1990: Edward G Lakatta
Similar myocardial effects of aging and hypertension.
European heart journal 1990;11 Suppl G():29-38.
1990: Bohdan Lewartowski; Richard G Hansford; G A Langer; Edward G Lakatta
Contraction and sarcoplasmic reticulum Ca2+ content in single myocytes of guinea pig heart: effect of ryanodine.
The American journal of physiology 1990;259(4 Pt 2):H1222-9.
1990: T Guarnieri; Edward G Lakatta
Mechanism of myocardial contractile depression by clinical concentrations of ethanol. A study in ferret papillary muscles.
The Journal of clinical investigation 1990;85(5):1462-7.
1990: Edward G Lakatta
Changes in cardiovascular function with aging.
European heart journal 1990;11 Suppl C():22-9.
1990: Maurizio C Capogrossi; T Kaku; C R Filburn; D J Pelto; Richard G Hansford; Harold A Spurgeon; Edward G Lakatta
Phorbol ester and dioctanoylglycerol stimulate membrane association of protein kinase C and have a negative inotropic effect mediated by changes in cytosolic Ca2+ in adult rat cardiac myocytes.
Circulation research 1990;66(4):1143-55.
1990: Robert G Weiss; Edward G Lakatta; Gary Gerstenblith
Effects of amiloride on metabolism and contractility during reoxygenation in perfused rat hearts.
Circulation research 1990;66(4):1012-22.
1990: Robert G Weiss; Gary Gerstenblith; Edward G Lakatta
Calcium oscillations index the extent of calcium loading and predict functional recovery during reperfusion in rat myocardium.
The Journal of clinical investigation 1990;85(3):757-65.
1990: R A Josephson; Harold A Spurgeon; Edward G Lakatta
The hyperthyroid heart. An analysis of systolic and diastolic properties in single rat ventricular myocytes.
Circulation research 1990;66(3):773-81.
1990: Harold A Spurgeon; Michael D Stern; G Baartz; S Raffaeli; Richard G Hansford; A Talo; Edward G Lakatta; Maurizio C Capogrossi
Simultaneous measurement of Ca2+, contraction, and potential in cardiac myocytes.
The American journal of physiology 1990;258(2 Pt 2):H574-86.
1990: D G Renlund; Gary Gerstenblith; Jerome L Fleg; Lewis C Becker; Edward G Lakatta
Interaction between left ventricular end-diastolic and end-systolic volumes in normal humans.
The American journal of physiology 1990;258(2 Pt 2):H473-81.
1990: Jerome L Fleg; Gary Gerstenblith; Alan B Zonderman; Lewis C Becker; Myron L Weisfeldt; Paul T Costa; Edward G Lakatta
Prevalence and prognostic significance of exercise-induced silent myocardial ischemia detected by thallium scintigraphy and electrocardiography in asymptomatic volunteers.
Circulation 1990;81(2):428-36.
1990: Robert S Danziger; M Sakai; Edward G Lakatta; Richard G Hansford
Interactive alpha- and beta-adrenergic actions of norepinephrine in rat cardiac myocytes.
Journal of molecular and cellular cardiology 1990;22(1):111-23.
1989: M Sakai; Robert S Danziger; J M Staddon; Edward G Lakatta; Richard G Hansford
Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes.
Journal of molecular and cellular cardiology 1989;21(12):1327-36.
1989: Michael D Stern; Harold A Spurgeon; Richard G Hansford; Edward G Lakatta; Maurizio C Capogrossi
Optimum spectral windows to minimize quantum noise of ratiometric intracellular fluorescent probes.
Cell calcium 1989;10(8):527-34.
1989: Edward G Lakatta
Mechanisms of hypertension in the elderly.
Journal of the American Geriatrics Society 1989;37(8):780-90.
1989: Michael D Stern; H F Weisman; D G Renlund; Gary Gerstenblith; O Hano; P S Blank; Edward G Lakatta
Laser backscatter studies of intracellular Ca2+ oscillations in isolated hearts.
The American journal of physiology 1989;257(2 Pt 2):H665-73.
1989: A Fraticelli; R Josephson; Robert S Danziger; Edward G Lakatta; Harold A Spurgeon
Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence.
The American journal of physiology 1989;257(1 Pt 2):H259-65.
1988: Michael D Stern; Maurizio C Capogrossi; Edward G Lakatta
Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences.
Cell calcium 1988;9(5-6):247-56.
1988: A A Kort; Edward G Lakatta
Spontaneous sarcoplasmic reticulum calcium release in rat and rabbit cardiac muscle: relation to transient and rested-state twitch tension.
Circulation research 1988;63(5):969-79.
1988: A A Kort; Edward G Lakatta
Bimodal effect of stimulation on light fluctuation transients monitoring spontaneous sarcoplasmic reticulum calcium release in rat cardiac muscle.
Circulation research 1988;63(5):960-8.
1988: Michael E. McIvor; C H Orchard; Edward G Lakatta
Dissociation of changes in apparent myofibrillar Ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle.
The Journal of general physiology 1988;92(4):509-29.
1988: Michael D Stern; HS Silverman; Steven R Houser; R A Josephson; Maurizio C Capogrossi; C G Nichols; William Lederer; Edward G Lakatta
Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6954-8.
1988: Jerome L Fleg; Edward G Lakatta
Role of muscle loss in the age-associated reduction in VO2 max.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(3):1147-51.
1988: G D Walford; H A Spurgeon; Edward G Lakatta
Diminished cardiac hypertrophy and muscle performance in older compared with younger adult rats with chronic atrioventricular block.
Circulation research 1988;63(3):502-11.
1988: Robert S Danziger; S Raffaeli; Rafael Moreno-Sanchez; M Sakai; Maurizio C Capogrossi; Harold A Spurgeon; Richard G Hansford; Edward G Lakatta
Extracellular ATP has a potent effect to enhance cytosolic calcium and contractility in single ventricular myocytes.
Cell calcium 1988;9(4):193-9.
1988: Maurizio C Capogrossi; Michael D Stern; Harold A Spurgeon; Edward G Lakatta
Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium.
The Journal of general physiology 1988;91(1):133-55.
1987: Edward G Lakatta
Catecholamines and cardiovascular function in aging.
Endocrinology and metabolism clinics of North America 1987;16(4):877-91.
1987: D G Renlund; Edward G Lakatta; Jerome L Fleg; Lewis C Becker; J F Clulow; Myron L Weisfeldt; Gary Gerstenblith
Prolonged decrease in cardiac volumes after maximal upright bicycle exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(5):1947-55.
1987: Maurizio C Capogrossi; Steven R Houser; A Bahinski; Edward G Lakatta
Synchronous occurrence of spontaneous localized calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential.
Circulation research 1987;61(4):498-503.
1987: Richard G Hansford; Edward G Lakatta
Ryanodine releases calcium from sarcoplasmic reticulum in calcium-tolerant rat cardiac myocytes.
The Journal of physiology 1987;390():453-67.
1987: C H Orchard; Steven R Houser; A A Kort; A Bahinski; Maurizio C Capogrossi; Edward G Lakatta
Acidosis facilitates spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium.
The Journal of general physiology 1987;90(1):145-65.
1986: Maurizio C Capogrossi; A A Kort; H A Spurgeon; Edward G Lakatta
Single adult rabbit and rat cardiac myocytes retain the Ca2+- and species-dependent systolic and diastolic contractile properties of intact muscle.
The Journal of general physiology 1986;88(5):589-613.
1985: Edward G Lakatta; Maurizio C Capogrossi; A A Kort; M D Stern
Spontaneous myocardial calcium oscillations: overview with emphasis on ryanodine and caffeine.
Federation proceedings 1985;44(15):2977-83.
1985: A A Kort; Maurizio C Capogrossi; Edward G Lakatta
Frequency, amplitude, and propagation velocity of spontaneous Ca++-dependent contractile waves in intact adult rat cardiac muscle and isolated myocytes.
Circulation research 1985;57(6):844-55.
1985: A A Kort; Edward G Lakatta; Eduardo Marban; M D Stern; Withrow Wier
Fluctuations in intracellular calcium concentration and their effect on tonic tension in canine cardiac Purkinje fibres.
The Journal of physiology 1985;367():291-308.
1983: Withrow Wier; A A Kort; M D Stern; Edward G Lakatta; Eduardo Marban
Cellular calcium fluctuations in mammalian heart: direct evidence from noise analysis of aequorin signals in Purkinje fibers.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7367-71.
1983: M D Stern; A A Kort; G M Bhatnagar; Edward G Lakatta
Scattered-light intensity fluctuations in diastolic rat cardiac muscle caused by spontaneous Ca++-dependent cellular mechanical oscillations.
The Journal of general physiology 1983;82(1):119-53.