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Jonathan Lakey

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M Reza Mirbolooki; Michael Alexander; David B Hoyt; Jonathan R T Lakey
Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation?
M Reza Mirbolooki; George E Taylor; Victor K Knutzen; David W Scharp; Robin Willcourt; Jonathan R T Lakey
Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications?
Tatsuya Kin; John J O'Neil; Rena Pawlick; Gregory S Korbutt; A M James Shapiro; Jonathan R T Lakey
The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.

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All Publications

2010: M Reza Mirbolooki; Michael Alexander; David B Hoyt; Jonathan R T Lakey
Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation?
Transplant immunology 2010;22(3-4):191-4.
2009: M Reza Mirbolooki; George E Taylor; Victor K Knutzen; David W Scharp; Robin Willcourt; Jonathan R T Lakey
Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications?
Medical hypotheses 2009;73(3):363-9.
2008: Tatsuya Kin; John J O'Neil; Rena Pawlick; Gregory S Korbutt; A M James Shapiro; Jonathan R T Lakey
The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.
Artificial organs 2008;32(12):990-3.
2008: George Bikopoulos; Aurelio da Silva Pimenta; Simon C Lee; Jonathan R T Lakey; Sandy D Der; Catherine B Chan; Rolando Bacis Ceddia; Michael B Wheeler; Maria Rozakis-Adcock
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids.
The Journal of endocrinology 2008;196(3):455-64.
2008: Wilma L Suarez-Pinzon; Jonathan R T Lakey; Alex Rabinovitch
Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice.
Cell transplantation 2008;17(6):631-40.
2007: Patricia M Campbell; A Salam; Edmond A Ryan; Peter Senior; Breay W Paty; David L Bigam; Tara McCready; Anne M Halpin; Sharleen Imes; Faisal Al-Saif; Jonathan R T Lakey; A M James Shapiro
Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1242-8.
2007: Tatsuya Kin; X Zhai; Travis B Murdoch; A Salam; A M James Shapiro; Jonathan R T Lakey
Enhancing the success of human islet isolation through optimization and characterization of pancreas dissociation enzyme.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1233-41.
2007: Tatsuya Kin; Paul R V Johnson; A M James Shapiro; Jonathan R T Lakey
Factors influencing the collagenase digestion phase of human islet isolation.
Transplantation 2007;83(1):7-12.
2007: Jonathan R T Lakey; Tatsuya Kin; Garth L Warnock; A M James Shapiro; Panagiotis Tsapogas; Sharleen Imes; Gregory S Korbutt; Norman M Kneteman; Ray V Rajotte; Edmond A Ryan
Long-term graft function after allogeneic islet transplantation.
Cell transplantation 2007;16(4):441-6.
2007: Tatsuya Kin; Shawn Rosichuk; A M James Shapiro; Jonathan R T Lakey
Detection of microbial contamination during human islet isolation.
Cell transplantation 2007;16(1):9-13.
2007: Jonathan R T Lakey; Mohammadreza Mirbolooki; Christina Rogers; Jim Mohr
Demand for human allograft tissue in Canada.
Cell and tissue banking 2007;8(1):31-42.
2007: Jonathan R T Lakey; Mohammadreza Mirbolooki; Christina Rogers; Jim Mohr
Supply of human allograft tissue in Canada.
Cell and tissue banking 2007;8(2):135-50.
2006: Shaheed Merani; Colleen D Schur; Wayne Truong; Victor K Knutzen; Jonathan R T Lakey; Colin C Anderson; Camillo Ricordi; A M James Shapiro
Compaction of islets is detrimental to transplant outcome in mice.
Transplantation 2006;82(11):1472-6.
2006: Jose G Avila; Yong Wang; Barbara Barbaro; ANTONIO GANGEMI; Meirigeng Qi; Joseph Kuechle; N Doubleday; M Doubleday; Thomas A Churchill; Payam Salehi; J Shapiro; L H Philipson; Enrico Benedetti; Jonathan R T Lakey; José Oberholzer
Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(12):2861-70.
2006: Tatsuya Kin; Mohammadreza Mirbolooki; Payam Salehi; Manabu Tsukada; Doug O'Gorman; Sharleen Imes; Edmond A Ryan; A M James Shapiro; Jonathan R T Lakey
Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon.
Transplantation 2006;82(10):1286-90.
2006: Steven R Meyer; Brian Chiu; Thomas A Churchill; Linfu Zhu; Jonathan R T Lakey; David B Ross
Comparison of aortic valve allograft decellularization techniques in the rat.
Journal of biomedical materials research. Part A 2006;79(2):254-62.
2006: Takuya Fukazawa; Junji Matsuoka; Yoshio Naomoto; Toru Nakai; Mary L Durbin; Itaru Kojima; Jonathan R T Lakey; Noriaki Tanaka
Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures.
Experimental cell research 2006;312(17):3404-12.
2006: C T Bussiere; Jonathan R T Lakey; A M James Shapiro; Gregory S Korbutt
The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells.
Diabetologia 2006;49(10):2341-9.
2006: Faisal Alsaif; Michele Molinari; Abdulmuttalib Al-Masloom; Jonathan R T Lakey; Tatsuya Kin; A M James Shapiro
Pancreatic islet autotransplantation with completion pancreatectomy in the management of uncontrolled pancreatic fistula after whipple resection for ampullary adenocarcinoma.
Pancreas 2006;32(4):430-1.
2006: Breay W Paty; Peter Senior; Jonathan R T Lakey; A M James Shapiro; Edmond A Ryan
Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects.
Diabetes technology & therapeutics 2006;8(2):165-73.
2006: Ergeng Hao; Björn Tyrberg; Pamela Itkin-Ansari; Jonathan R T Lakey; Ifat Geron; Edward Monosov; Maria Barcova; Mark Mercola; Fred Levine
Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.
Nature medicine 2006;12(3):310-6.
2006: Mohammadreza Mirbolooki; Jonathan R T Lakey
Oxygen and pancreas preservation.
Transplantation 2006;81(3):492; author reply 492-3.
2006: Karen Seeberger; Jannette M Dufour; Andrew M James Shapiro; Jonathan R T Lakey; Ray V Rajotte; Gregory S Korbutt
Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):141-53.
2006: Atsushi Miki; Michiki Narushima; Teru Okitsu; Yuichi Takeno; Alejandro Soto-Gutierrez; Jorge David Rivas-Carrillo; Nalu Navarro-Alvarez; Yong Chen; Kimiaki Tanaka; Hirofumi Noguchi; Shinichi Matsumoto; Michinori Kohara; Jonathan R T Lakey; Eiji Kobayashi; Noriaki Tanaka; Naoya Kobayashi
Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts.
Cell transplantation 2006;15(4):325-34.
2006: Jonathan R T Lakey; Mohammadreza Mirbolooki; A M James Shapiro
Current status of clinical islet cell transplantation.
Methods in molecular biology (Clifton, N.J.) 2006;333():47-104.
2006: Helena Miszta-Lane; Mohammadreza Mirbolooki; AM James Shapiro; Jonathan R T Lakey
Stem cell sources for clinical islet transplantation in type 1 diabetes: embryonic and adult stem cells.
Medical hypotheses 2006;67(4):909-13.
2006: Payam Salehi; Mohammadreza Mirbolooki; Tatsuya Kin; Toshiaki Tsujimura; A M James Shapiro; Thomas A Churchill; Jonathan R T Lakey
Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution.
Cell transplantation 2006;15(2):187-94.
2006: Tatsuya Kin; Travis B Murdoch; A M James Shapiro; Jonathan R T Lakey
Estimation of pancreas weight from donor variables.
Cell transplantation 2006;15(2):181-5.
2006: Sue Swift; Tatsuya Kin; Mohammadreza Mirbolooki; Richard Wilson; Jonathan R T Lakey
Comparison of cooling systems during islet purification.
Cell transplantation 2006;15(2):175-80.
2005: P Villiger; Edmond A Ryan; R Owen; Kevin O'Kelly; José Oberholzer; Faisal Al-Saif; Tatsuya Kin; H Wang; I Larsen; Sandra Blitz; V Menon; Peter Senior; David L Bigam; Breay W Paty; Norman M Kneteman; Jonathan R T Lakey; A M James Shapiro
Prevention of bleeding after islet transplantation: lessons learned from a multivariate analysis of 132 cases at a single institution.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(12):2992-8.
2005: Michele Molinari; Faisal Al-Saif; Edmond A Ryan; Jonathan R T Lakey; Peter Senior; Breay W Paty; David L Bigam; Norman M Kneteman; A M James Shapiro
Sirolimus-induced ulceration of the small bowel in islet transplant recipients: report of two cases.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(11):2799-804.
2005: Doug O'Gorman; Tatsuya Kin; Deborah McGhee-Wilson; A M James Shapiro; Jonathan R T Lakey
Multi-lot analysis of custom collagenase enzyme blend in human islet isolations.
Transplantation proceedings 2005;37(8):3417-9.
2005: Michiki Narushima; Naoya Kobayashi; Teru Okitsu; Yoshihito Tanaka; Shun-Ai Li; Yong Chen; Atsushi Miki; Kimiaki Tanaka; Shuhei Nakaji; Kohji Takei; Alejandro Soto Gutierrez; Jorge David Rivas-Carrillo; Nalu Navarro-Alvarez; Hee-Sook Jun; Karen A Westerman; Hirofumi Noguchi; Jonathan R T Lakey; Philippe Leboulch; Noriaki Tanaka; Ji-Won Yoon
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Nature biotechnology 2005;23(10):1274-82.
2005: Stephanie M Gustavson; Ray V Rajotte; David Hunkeler; Jonathan R T Lakey; Dale S Edgerton; Doss W Neal; Wanda L Snead; Angelina R Penaloza; Alan D Cherrington
Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(10):2368-77.
2005: Doug O'Gorman; Tatsuya Kin; Travis B Murdoch; Brad Richer; Deborah McGhee-Wilson; Edmond A Ryan; James A M Shapiro; Jonathan R T Lakey
The standardization of pancreatic donors for islet isolations.
Transplantation 2005;80(6):801-6.
2005: Matthew J Barnett; Xiaojun Zhai; Donald F Legatt; Siew Bang Cheng; A M James Shapiro; Jonathan R T Lakey
Quantitative assessment of collagenase blends for human islet isolation.
Transplantation 2005;80(6):723-8.
2005: Juliet A Emamaullee; Ray V Rajotte; Peter Liston; Robert G Korneluk; Jonathan R T Lakey; A M James Shapiro; John Elliott
XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.
Diabetes 2005;54(9):2541-8.
2005: Steven R Meyer; Jayan Nagendran; Leena S Desai; Gina R Rayat; Thomas A Churchill; Colin C Anderson; Ray V Rajotte; Jonathan R T Lakey; David B Ross
Decellularization reduces the immune response to aortic valve allografts in the rat.
The Journal of thoracic and cardiovascular surgery 2005;130(2):469-76.
2005: Edmond A Ryan; Breay W Paty; Peter Senior; David L Bigam; Eman Alfadhli; Norman M Kneteman; Jonathan R T Lakey; A M James Shapiro
Five-year follow-up after clinical islet transplantation.
Diabetes 2005;54(7):2060-9.
2005: Wilma L Suarez-Pinzon; Jonathan R T Lakey; Stephen J Brand; Alex Rabinovitch
Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass.
The Journal of clinical endocrinology and metabolism 2005;90(6):3401-9.
2005: A M James Shapiro; Jonathan R T Lakey; Breay W Paty; Peter Senior; David L Bigam; Edmond A Ryan
Strategic opportunities in clinical islet transplantation.
Transplantation 2005;79(10):1304-7.
2005: Tatsuya Kin; James Shapiro; Edmond A Ryan; Jonathan R T Lakey
Islet isolation and transplantation from an annular pancreas: a case report.
JOP : Journal of the pancreas 2005;6(3):274-6.
2005: Tatsuya Kin; A M James Shapiro; Jonathan R T Lakey
Pancreas divisum: a study of the cadaveric donor pancreas for islet isolation.
Pancreas 2005;30(4):325-7.
2005: Steven R Meyer; Patricia M Campbell; Jennifer M Rutledge; Anne M Halpin; Lois E Hawkins; Jonathan R T Lakey; Ivan M Rebeyka; David B Ross
Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2005;27(4):554-60.
2005: Doug O'Gorman; Tatsuya Kin; Travis B Murdoch; B Richer; Deborah McGhee-Wilson; E Ryan; A M James Shapiro; Jonathan R T Lakey
The standardization of pancreatic donors for islet isolation.
Transplantation proceedings 2005;37(2):1309-10.
2005: Edmond A Ryan; Breay W Paty; Peter Senior; Jonathan R T Lakey; David L Bigam; A M James Shapiro
Beta-score: an assessment of beta-cell function after islet transplantation.
Diabetes care 2005;28(2):343-7.
2005: A M James Shapiro; Heather L Gallant; Er Geng Hao; Jonathan R T Lakey; Tara McCready; Ray V Rajotte; Randall W Yatscoff; Norman M Kneteman
The portal immunosuppressive storm: relevance to islet transplantation?
Therapeutic drug monitoring 2005;27(1):35-7.
2005: Wayne Truong; Jonathan R T Lakey; Edmond A Ryan; A M James Shapiro
Clinical islet transplantation at the University of Alberta--the Edmonton experience.
Clinical transplants 2005;():153-72.
2004: Cale N Street; Jonathan R T Lakey; A M James Shapiro; Sharleen Imes; Ray V Rajotte; Edmond A Ryan; James G Lyon; Tatsuya Kin; Jose Avila; Toshiaki Tsujimura; Gregory S Korbutt
Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.
Diabetes 2004;53(12):3107-14.
2004: Charlotte G McDonald; Edmond A Ryan; Breay W Paty; Peter Senior; Sally M Marshall; Jonathan R T Lakey; A M James Shapiro
Cross-sectional and prospective association between proinsulin secretion and graft function after clinical islet transplantation.
Transplantation 2004;78(6):934-7.
2004: Naoya Kobayashi; Takashi Arata; Teru Okitsu; Hideaki Ikeda; Kazuya Kobayashi; Yoshikazu Kosaka; Michiki Narushima; Noriaki Tanaka; Jonathan R T Lakey
Transduction of human islets with the lentiviral vector.
Transplantation proceedings 2004;36(7):2203-4.
2004: Toshiaki Tsujimura; Yoshikazu Kuroda; Jose G Avila; Tatsuya Kin; José Oberholzer; A M James Shapiro; Jonathan R T Lakey
Influence of pancreas preservation on human islet isolation outcomes: impact of the two-layer method.
Transplantation 2004;78(1):96-100.
2004: Takashi Arata; Teru Okitsu; Takuya Fukazawa; Hideaki Ikeda; Kazuya Kobayashi; Chen Yong; Yoshikazu Kosaka; Michiki Narushima; Junji Matsuoka; Itaru Yamamoto; Noriaki Tanaka; Jonathan R T Lakey; Naoya Kobayashi
Maintenance of glucose-sensitive insulin secretion of cryopreserved human islets with University of Wisconsin solution and ascorbic acid-2 glucoside.
Artificial organs 2004;28(6):529-36.
2004: Erik J Woods; C M Walsh; R A Sidner; M A J Zieger; Jonathan R T Lakey; Camillo Ricordi; John K Critser
Improved in vitro function of islets using small intestinal submucosa.
Transplantation proceedings 2004;36(4):1175-7.
2004: Erik J Woods; C M Walsh; R A Sidner; M A J Zieger; S Mullin; Jonathan R T Lakey; Camillo Ricordi; John K Critser
Enhanced recovery of cryopreserved islets using SIS.
Transplantation proceedings 2004;36(4):1139-42.
2004: Ravi Bhargava; Peter Senior; Thomas E Ackerman; Edmond A Ryan; Breay W Paty; Jonathan R T Lakey; A M James Shapiro
Prevalence of hepatic steatosis after islet transplantation and its relation to graft function.
Diabetes 2004;53(5):1311-7.
2004: Payam Salehi; Karen Madsen; Jay Zhu; Erika Castillo; Jose Avila; Jonathan R T Lakey; Thomas A Churchill
Alleviating ischemia-reperfusion injury in small bowel.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(5):728-37.
2004: Cale N Street; Jonathan R T Lakey; Karen Seeberger; Lisa M H Helms; Ray V Rajotte; A M James Shapiro; Gregory S Korbutt
Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker.
The Journal of endocrinology 2004;180(2):213-25.
2004: Cale N Street; Jonathan R T Lakey; Ray V Rajotte; A M James Shapiro; Timothy J Kieffer; James G Lyon; Tatsuya Kin; Gregory S Korbutt
Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.
The review of diabetic studies : RDS 2004;1(2):66-79.
2004: Travis B Murdoch; Deborah McGhee-Wilson; A M James Shapiro; Jonathan R T Lakey
Methods of human islet culture for transplantation.
Cell transplantation 2004;13(6):605-17.
2004: M J Barnett; Deborah McGhee-Wilson; A M James Shapiro; Jonathan R T Lakey
Variation in human islet viability based on different membrane integrity stains.
Cell transplantation 2004;13(5):481-8.
2004: A T L Young; Ronald B Moore; Allan G Murray; John C Mullen; Jonathan R T Lakey
Assessment of different transfection parameters in efficiency optimization.
Cell transplantation 2004;13(2):179-85.
2004: Natisha L Rose; Monica Palcic; A M James Shapiro; Jonathan R T Lakey
Endogenous pancreatic enzyme activity levels show no significant effect on human islet isolation yield.
Cell transplantation 2004;13(2):153-60.
2004: Naoya Kobayashi; Teru Okitsu; Jonathan R T Lakey; Noriaki Tanaka
The current situation in human pancreatic islet transplantation: problems and prospects.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2004;7(1):1-8.
2004: Toshiaki Tsujimura; Yoshikazu Kuroda; Thomas A Churchill; Jose G Avila; Tatsuya Kin; A M James Shapiro; Jonathan R T Lakey
Short-term storage of the ischemically damaged human pancreas by the two-layer method prior to islet isolation.
Cell transplantation 2004;13(1):67-73.
2003: A M James Shapiro; Sulaiman A Nanji; Jonathan R T Lakey
Clinical islet transplant: current and future directions towards tolerance.
Immunological reviews 2003;196():219-36.
2003: Ehab Rafael; Edmond A Ryan; Breay W Paty; José Oberholzer; Sharleen Imes; Peter Senior; Charlotte McDonald; Jonathan R T Lakey; A M James Shapiro
Changes in liver enzymes after clinical islet transplantation.
Transplantation 2003;76(9):1280-4.
2003: A T L Young; Jonathan R T Lakey; Allan G Murray; John C Mullen; Ronald B Moore
In vitro senescence occurring in normal human endothelial cells can be rescued by ectopic telomerase activity.
Transplantation proceedings 2003;35(7):2483-5.
2003: Toshiaki Tsujimura; Yoshikazu Kuroda; Jose G Avila; Tatsuya Kin; Thomas A Churchill; A M James Shapiro; Jonathan R T Lakey
Resuscitation of the ischemically damaged human pancreas by the two-layer method prior to islet isolation.
Transplantation proceedings 2003;35(7):2461-2.
2003: Natisha L Rose; Monica Palcic; A M James Shapiro; Jonathan R T Lakey
An evaluation of endogenous pancreatic enzyme levels following enzymatic digestion.
Transplantation proceedings 2003;35(7):2458-60.
2003: Natisha L Rose; Monica Palcic; A M James Shapiro; Jonathan R T Lakey
An evaluation of the activation of endogenous pancreatic enzymes during human islet isolations.
Transplantation proceedings 2003;35(7):2455-7.
2003: Richard J Owen; Edmond A Ryan; Kevin O'Kelly; Jonathan R T Lakey; Mairin C McCarthy; Breay W Paty; David L Bigam; Norman M Kneteman; Gregory S Korbutt; Ray V Rajotte; A M James Shapiro
Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.
Radiology 2003;229(1):165-70.
2003: Jonathan R T Lakey; Philip W Burridge; A M James Shapiro
Technical aspects of islet preparation and transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2003;16(9):613-32.
2003: Natisha L Rose; Monica Palcic; Jonathan R T Lakey
An evaluation of endogenous pancreatic enzyme levels after human islet isolation.
Pancreas 2003;27(2):167-73.
2003: Jay Z J Zhu; Erika G Castillo; Payam Salehi; Jose Avila; Jonathan R T Lakey; Thomas A Churchill
A novel technique of hypothermic luminal perfusion for small bowel preservation.
Transplantation 2003;76(1):71-6.
2003: Natisha L Rose; Monica Palcic; Lisa M H Helms; Jonathan R T Lakey
Evaluation of Pefabloc as a serine protease inhibitor during human-islet isolation.
Transplantation 2003;75(4):462-6.
2003: Wen-Tsoung Lu; Jonathan R T Lakey; Jyuhn-Huarng Juang; B R-S Hsu; Ray V Rajotte
Effect of trypsin inhibitor on islet isolation from fresh and cold preserved rat pancreas.
Transplantation proceedings 2003;35(1):488-9.
2003: Jose G Avila; Toshiaki Tsujimura; José Oberholzer; Thomas A Churchill; Payam Salehi; A M James Shapiro; Jonathan R T Lakey
Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure.
Cell transplantation 2003;12(8):877-81.
2003: José Oberholzer; A M James Shapiro; Jonathan R T Lakey; Edmond A Ryan; Ray V Rajotte; Gregory S Korbutt; Philippe Morel; Norman M Kneteman
Current status of islet cell transplantation.
Advances in surgery 2003;37():253-82.
2003: Jonathan R T Lakey; Lisa M H Helms; Gabrielle Moser; Bruce Lix; Carolyn Slupsky; Ivan M Rebeyka; Brian D Sykes; Locksley E McGann
Dynamics of cryoprotectant permeation in porcine heart valve leaflets.
Cell transplantation 2003;12(2):123-8.
2002: Jonathan R T Lakey; Toshiaki Tsujimura; A M James Shapiro; Yoshikazu Kuroda
Preservation of the human pancreas before islet isolation using a two-layer (UW solution-perfluorochemical) cold storage method.
Transplantation 2002;74(12):1809-11.
2002: Toshiaki Tsujimura; Yoshikazu Kuroda; Tatsuya Kin; Jose G Avila; Ray V Rajotte; Gregory S Korbutt; Edmond A Ryan; A M James Shapiro; Jonathan R T Lakey
Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method.
Transplantation 2002;74(12):1687-91.
2002: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts.
Transplantation 2002;74(11):1522-8.
2002: P W Burridge; A M James Shapiro; Edmond A Ryan; Jonathan R T Lakey
Future trends in clinical islet transplantation.
Transplantation proceedings 2002;34(8):3347-8.
2002: Gillian M Beattie; Anthony M P Montgomery; Ana D Lopez; Ergeng Hao; Brandon Perez; Margaret L Just; Jonathan R T Lakey; Marquis E Hart; Alberto Hayek
A novel approach to increase human islet cell mass while preserving beta-cell function.
Diabetes 2002;51(12):3435-9.
2002: Breay W Paty; Edmond A Ryan; A M James Shapiro; Jonathan R T Lakey; R Paul Robertson
Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence.
Diabetes 2002;51(12):3428-34.
2002: Wen-Tsoung Lu; Jonathan R T Lakey; Jyuhn-Huarng Juang; B R-S Hsu; Ray V Rajotte
Effect of pefabloc on islet isolation from cold preserved rat pancreas.
Transplantation proceedings 2002;34(7):2700-1.
2002: Patrick E MacDonald; Guotang Wang; Sharon Tsuk; Chikvashvili Dodo; Youhou Kang; Lan Tang; Michael B Wheeler; Mark S Cattral; Jonathan R T Lakey; Anne Marie F Salapatek; Ilana Lotan; Herbert Y Gaisano
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
Molecular endocrinology (Baltimore, Md.) 2002;16(11):2452-61.
2002: John J Casey; Jonathan R T Lakey; Edmond A Ryan; Breay W Paty; Richard Owen; Kevin O'Kelly; Sulaiman Nanji; Ray V Rajotte; Gregory S Korbutt; David L Bigam; Norman N Kneteman; A M James Shapiro
Portal venous pressure changes after sequential clinical islet transplantation.
Transplantation 2002;74(7):913-5.
2002: John Gerard Geisler; Walter S Zawalich; Kathleen C Zawalich; Jonathan R T Lakey; Hans A Stukenbrok; Anthony J Milici; Walter Soeller
Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide.
Diabetes 2002;51(7):2158-69.
2002: Edmond A Ryan; Jonathan R T Lakey; Breay W Paty; Sharleen Imes; Gregory S Korbutt; Norman M Kneteman; David L Bigam; Ray V Rajotte; A M James Shapiro
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Diabetes 2002;51(7):2148-57.
2002: Jonathan R T Lakey; Norman M Kneteman; Ray V Rajotte; Douglas C Wu; David L Bigam; A M James Shapiro
Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability.
Transplantation 2002;73(7):1106-10.
2002: Natisha L Rose; Monica Palcic; Jonathan R T Lakey
Evaluating the effect of serine proteases on collagenase activity during human islet isolation.
Cell transplantation 2002;11(8):821-6.
2002: A T L Young; Jonathan R T Lakey; Allan G Murray; Ronald B Moore
Gene therapy: a lipofection approach for gene transfer into primary endothelial cells.
Cell transplantation 2002;11(6):573-82.
2001: A M James Shapiro; Edmond A Ryan; Jonathan R T Lakey
Diabetes. Islet cell transplantation.
Lancet 2001;358 Suppl():S21.
2001: Jonathan R T Lakey; Wilma L Suarez-Pinzon; Ken Strynadka; Gregory S Korbutt; Ray V Rajotte; Francisco Soriano; Csaba Szabó; Alex Rabinovitch
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(12):1683-92.
2001: A M James Shapiro; Edmond A Ryan; Jonathan R T Lakey
Clinical islet transplant--state of the art.
Transplantation proceedings 2001;33(7-8):3502-3.
2001: Edmond A Ryan; Jonathan R T Lakey; A M James Shapiro
Clinical results after islet transplantation.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2001;49(6):559-62.
2001: Jonathan R T Lakey; T J Anderson; Ray V Rajotte
Novel approaches to cryopreservation of human pancreatic islets.
Transplantation 2001;72(6):1005-11.
2001: Jonathan R T Lakey; Lisa M H Helms; Tatsuya Kin; Gregory S Korbutt; Ray V Rajotte; A M James Shapiro; Garth L Warnock
Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.
Transplantation 2001;72(4):565-70.
2001: David F Mercer; D E Schiller; John Elliott; Donna N Douglas; C Hao; A Rinfret; William R Addison; Karl P Fischer; Thomas A Churchill; Jonathan R T Lakey; D Lorne J Tyrrell; Norman M Kneteman
Hepatitis C virus replication in mice with chimeric human livers.
Nature medicine 2001;7(8):927-33.
2001: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; W J Yakimets; Thomas A Churchill; Paraskevi G Mitlianga; George K Papadopoulos; John Elliott; Ray V Rajotte; Norman M Kneteman
Novel approaches toward early diagnosis of islet allograft rejection.
Transplantation 2001;71(12):1709-18.
2001: A M James Shapiro; Edmond A Ryan; Jonathan R T Lakey
Pancreatic islet transplantation in the treatment of diabetes mellitus.
Best practice & research. Clinical endocrinology & metabolism 2001;15(2):241-64.
2001: Edmond A Ryan; Jonathan R T Lakey; Ray V Rajotte; Gregory S Korbutt; Tatsuya Kin; Sharleen Imes; Alex Rabinovitch; John Elliott; David L Bigam; Norman M Kneteman; Garth L Warnock; I Larsen; A M James Shapiro
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.
Diabetes 2001;50(4):710-9.
2001: Jonathan R T Lakey; A T L Young; D Pardue; S Calvin; TE Albertson; L Jacobson; TJ Cavanagh
Nonviral transfection of intact pancreatic islets.
Cell transplantation 2001;10(8):697-708.
2001: CA Fedorow; Locksley E McGann; Gregory S Korbutt; Gina R Rayat; Ray V Rajotte; Jonathan R T Lakey
Osmotic and cryoprotectant permeation characteristics of islet cells isolated from the newborn pig pancreas.
Cell transplantation 2001;10(7):651-9.
2001: Jonathan R T Lakey; Ray V Rajotte; CA Fedorow; M J Taylor
Islet cryopreservation using intracellular preservation solutions.
Cell transplantation 2001;10(7):583-9.
2000: A M James Shapiro; Jonathan R T Lakey; Edmond A Ryan; Gregory S Korbutt; E Toth; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
The New England journal of medicine 2000;343(4):230-8.
2000: A M James Shapiro; Jonathan R T Lakey
Future trends in islet cell transplantation.
Diabetes technology & therapeutics 2000;2(3):449-52.
1999: Erik J Woods; J Liu; M A J Zieger; Jonathan R T Lakey; John K Critser
The effects of microencapsulation on pancreatic islet osmotically induced volumetric response.
Cell transplantation 1999;8(6):699-708.
1999: Jonathan R T Lakey; CA Aspinwall; TJ Cavanagh; Robert T Kennedy
Secretion from islets and single islet cells following cryopreservation.
Cell transplantation 1999;8(6):691-8.
1999: Garth L Warnock; Jonathan R T Lakey
Cryopreservation of human islets of Langerhans.
Transplantation 1999;68(5):597-8.
1999: Erik J Woods; J Liu; M A J Zieger; Jonathan R T Lakey; John K Critser
Water and cryoprotectant permeability characteristics of isolated human and canine pancreatic islets.
Cell transplantation 1999;8(5):549-59.
1999: Jonathan R T Lakey; Garth L Warnock; A M James Shapiro; Gregory S Korbutt; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Cell transplantation 1999;8(3):285-92.
1999: M A J Zieger; Erik J Woods; Jonathan R T Lakey; J Liu; John K Critser
Osmotic tolerance limits of canine pancreatic islets.
Cell transplantation 1999;8(3):277-84.
1998: Jonathan R T Lakey; TJ Cavanagh; M A J Zieger
A prospective comparison of discontinuous EuroFicoll and EuroDextran gradients for islet purification.
Cell transplantation 1998;7(5):479-87.
1998: M S Cattral; Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Effect of cryopreservation on the survival and function of murine islet isografts and allografts.
Cell transplantation 1998;7(4):373-9.
1998: Jonathan R T Lakey; TJ Cavanagh; M A J Zieger; M Wright
Evaluation of a purified enzyme blend for the recovery and function of canine pancreatic islets.
Cell transplantation 1998;7(4):365-72.
1998: Jonathan R T Lakey
Examination of microbiological contamination rates following bacterial culture and incubation for 2, 7, and 14 days.
Transplantation proceedings 1998;30(2):664.
1998: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; John Elliott; Ray V Rajotte; Norman M Kneteman
Development of diagnostic markers for islet allograft rejection.
Transplantation proceedings 1998;30(2):647.
1998: Jonathan R T Lakey; TJ Cavanagh; M A J Zieger; TE Albertson; FE Dwulet; MJ Wright; TJ Fetterhoff
Evaluation of a purified enzyme blend for the recovery and in vitro function of isolated canine islets.
Transplantation proceedings 1998;30(2):590-1.
1998: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Diabetogenic synergism in canine islet autografts from cyclosporine and steroids in combination.
Transplantation proceedings 1998;30(2):527.
1998: Jonathan R T Lakey; D Pardue; S Calvin; TE Albertson; TJ Cavanagh; L Jacobsen
Nonviral transfection of isolated islets of Langerhans.
Transplantation proceedings 1998;30(2):469.
1998: Erik J Woods; Jonathan R T Lakey; M A J Zieger; J Liu; John K Critser
Osmotic responses of isolated canine islets to novel cryoprotectants.
Transplantation proceedings 1998;30(2):388-9.
1998: Jonathan R T Lakey; J Troendle; M A J Zieger; W A Geary; S Voytek; John K Critser
Improved islet survival and in vitro function using small intestinal submucosa.
Transplantation proceedings 1998;30(2):383.
1998: Jonathan R T Lakey; CA Aspinwall; TJ Cavanagh; Robert T Kennedy
Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques.
Transplantation proceedings 1998;30(2):382.
1998: Jonathan R T Lakey; M A J Zieger; Erik J Woods; John K Critser; J R Wright
Permeability characteristics of isolated Brockmann bodies.
Transplantation proceedings 1998;30(2):380.
1998: TJ Cavanagh; Jonathan R T Lakey; MJ Wright; TE Albertson; KJ Wile; TJ Fetterhoff
Identification of a pig strain with maximal islet mass.
Transplantation proceedings 1998;30(2):368.
1998: TJ Cavanagh; Jonathan R T Lakey; FE Dwulet; MJ Wright; KJ Wile; TE Albertson; TJ Fetterhoff
Improved pig islet yield and post-culture recovery using Liberase PI purified enzyme blend.
Transplantation proceedings 1998;30(2):367.
1998: Jonathan R T Lakey; Garth L Warnock; Ziliang Ao; A M James Shapiro; Gregory S Korbutt; Norman M Kneteman; Ray V Rajotte
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Transplantation proceedings 1998;30(2):359.
1998: Jonathan R T Lakey; TJ Cavanagh; M A J Zieger; John K Critser
A prospective comparison of discontinuous Euroficoll and Eurodextran gradients for islet purification.
Transplantation proceedings 1998;30(2):348.
1998: Jonathan R T Lakey; M E Smith; TJ Fetterhoff; TJ Cavanagh; MJ Wright; FE Dwulet
Sterile filtration of collagenase solution: effect of filter membrane composition on enzyme recovery.
Transplantation proceedings 1998;30(2):347.
1997: Erik J Woods; M A J Zieger; Jonathan R T Lakey; J Liu; John K Critser
Osmotic characteristics of isolated human and canine pancreatic islets.
Cryobiology 1997;35(2):106-13.
1997: J Liu; M A J Zieger; Jonathan R T Lakey; Erik J Woods; John K Critser
The determination of membrane permeability coefficients of canine pancreatic islet cells and their application to islet cryopreservation.
Cryobiology 1997;35(1):1-13.
1997: Jonathan R T Lakey; M A J Zieger; Erik J Woods; J Liu; John K Critser
Hypoosmotic exposure of canine pancreatic digest as a means to purify islet tissue.
Cell transplantation 1997;6(4):423-8.
1997: Erik J Woods; Jonathan R T Lakey; M A J Zieger; J Liu; D Nelson; John K Critser
Permeability characteristics of microencapsulated pancreatic islets.
Transplantation proceedings 1997;29(4):2148.
1997: J Liu; M A J Zieger; Jonathan R T Lakey; Erik J Woods; John K Critser
Water and DMSO permeability at 22 degrees C, 5 degrees C, and -3 degrees C for human pancreatic islet cells.
Transplantation proceedings 1997;29(4):1987.
1997: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Optimization of removal of cryoprotectant from frozen-thawed islets.
Transplantation proceedings 1997;29(4):1986.
1997: Jonathan R T Lakey; Garth L Warnock; M Brierton; Ziliang Ao; B J Hering; N London; Camillo Ricordi; F Corbin; Ray V Rajotte
Development of an automated computer-controlled islet isolation system.
Transplantation proceedings 1997;29(4):1956.
1997: TJ Cavanagh; Jonathan R T Lakey; MJ Wright; TJ Fetterhoff; KJ Wile
Crude collagenase loses islet-isolating efficacy regardless of storage conditions.
Transplantation proceedings 1997;29(4):1942-4.
1997: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Comparison of methods used for the removal of DMSO following cryopreservation and the development of an automated protocol.
Cell transplantation 1997;6(2):163-72.
1997: Jonathan R T Lakey; Garth L Warnock; M Brierton; Ziliang Ao; B J Hering; N J London; Camillo Ricordi; F Corbin; Ray V Rajotte
Development of an automated computer-controlled islet isolation system.
Cell transplantation 1997;6(1):47-57.
1996: Jonathan R T Lakey; Garth L Warnock; Ziliang Ao; Ray V Rajotte
Bulk cryopreservation of isolated islets of Langerhans.
Cell transplantation 1996;5(3):395-404.
1996: Norman M Kneteman; Jonathan R T Lakey; T Wagner; Diane T Finegood
The metabolic impact of rapamycin (sirolimus) in chronic canine islet graft recipients.
Transplantation 1996;61(8):1206-10.
1996: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte; M E Suarez-Alamazor; Ziliang Ao; A M James Shapiro; Norman M Kneteman
Variables in organ donors that affect the recovery of human islets of Langerhans.
Transplantation 1996;61(7):1047-53.
1996: L J Langman; A M James Shapiro; Jonathan R T Lakey; Donald F Legatt; Norman M Kneteman; Randall W Yatscoff
Pharmacodynamic assessment of mycophenolic acid in a canine model.
Transplantation proceedings 1996;28(2):934-6.
1996: Jonathan R T Lakey; Randall W Yatscoff; Arvind Koshal; Ray V Rajotte
Prolongation of concordant islet xenografts with leflunomide.
Transplantation proceedings 1996;28(2):816.
1996: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Intrathymic transplantation of fresh and cryopreserved islets for the induction of a state of unresponsiveness in rats.
Transplantation 1996;61(3):506-8.
1996: L J Langman; A M James Shapiro; Jonathan R T Lakey; Donald F Legatt; Norman M Kneteman; Randall W Yatscoff
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measurement of inosine monophosphate dehydrogenase activity in a canine model.
Transplantation 1996;61(1):87-92.
1996: P J Tuitoek; Jonathan R T Lakey; Ray V Rajotte; Tapan K Basu
Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1996;66(2):101-5.
1995: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; John Elliott; Ray V Rajotte
Dose dependence of bacillus Calmette-Guerin on the prevention of autoimmune diabetes in syngeneic islet transplantation.
Transplantation proceedings 1995;27(6):3413.
1995: Ray V Rajotte; Ziliang Ao; Gregory S Korbutt; Jonathan R T Lakey; M Flashner; C B Colby; Garth L Warnock
Cryopreservation of microencapsulated canine islets.
Transplantation proceedings 1995;27(6):3389.
1995: M S Cattral; Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Effect of cryopreservation on islet recovery and in vivo function.
Transplantation proceedings 1995;27(6):3336.
1995: Jonathan R T Lakey; Ziliang Ao; Garth L Warnock; Gregory S Korbutt; M Flashner; C B Colby; Ray V Rajotte
Recovery and in vivo function of canine islets cryopreserved in a freezer bag.
Transplantation proceedings 1995;27(6):3266.
1995: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte; Ziliang Ao; M E Suarez-Almazor; A M James Shapiro; Norman M Kneteman
Factors in cadaveric donors that affect recovery of human islets of Langerhans.
Transplantation proceedings 1995;27(6):3265.
1995: Norman M Kneteman; Jonathan R T Lakey; T Wagner; Diane T Finegood
Beneficial metabolic impact of the novel immunosuppressant rapamycin in chronic canine islet autograft recipients.
Transplantation proceedings 1995;27(6):3213.
1995: G I Warnock; P Tsapogas; Edmond A Ryan; Jonathan R T Lakey; Gregory S Korbutt; Norman M Kneteman; Ziliang Ao; Alex Rabinovitch; Ray V Rajotte
Natural history of insulin independence after transplantation of multidonor cryopreserved pancreatic islets in type 1 diabetic humans.
Transplantation proceedings 1995;27(6):3159-60.
1995: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; John Elliott; Ray V Rajotte
Long-term survival of syngeneic islet grafts in BCG-treated diabetic NOD mice can be reversed by cyclophosphamide.
Transplantation 1995;59(12):1751-3.
1995: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Microbial surveillance of human islet isolation, in vitro culture, and cryopreservation.
Clinical and investigative medicine. Médecine clinique et experimentale 1995;18(3):168-76.
1995: A M James Shapiro; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; M S Friedlich; L D Jewell; Norman M Kneteman
Portal vein thrombosis after transplantation of partially purified pancreatic islets in a combined human liver/islet allograft.
Transplantation 1995;59(7):1060-3.
1995: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; Norman M Kneteman
Human pancreas preservation prior to islet isolation. Cold ischemic tolerance.
Transplantation 1995;59(5):689-94.
1994: Anita Gainer; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Survival and function of human islets subjected to gamma-radiation.
Transplantation proceedings 1994;26(6):3457.
1994: Garth L Warnock; Jonathan R T Lakey; Ziliang Ao; Ray V Rajotte
Tissue banking of cryopreserved islets for clinical islet transplantation.
Transplantation proceedings 1994;26(6):3438.
1994: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; Norman M Kneteman
Cold ischemic tolerance of human pancreas: assessment of islet recovery and in vitro function.
Transplantation proceedings 1994;26(6):3416.
1994: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Conditions for the induction of unresponsiveness to cryopreserved islet allografts with intrathymic islets.
Transplantation proceedings 1994;26(6):3313.
1994: Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ziliang Ao; Ray V Rajotte
Development of a method for bulk cryopreservation of purified canine islets.
Transplantation proceedings 1994;26(6):3300.
1994: Norman M Kneteman; Jonathan R T Lakey; T A Kizilisik; Ziliang Ao; Garth L Warnock; Ray V Rajotte
Cadaver pancreas recovery technique. Impact on islet recovery and in vitro function.
Transplantation 1994;58(10):1114-9.
1994: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; Ray V Rajotte
BCG immunotherapy prevents recurrence of diabetes in islet grafts transplanted into spontaneously diabetic NOD mice.
Transplantation 1994;57(8):1213-7.
1994: Jonathan R T Lakey; Ray V Rajotte; Geoffrey D Taylor; T Kirkland; Garth L Warnock
Microbial studies of a tissue bank of cryopreserved human islet cells.
Transplantation proceedings 1994;26(2):827.
1994: Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ziliang Ao; Ray V Rajotte
Effects of pre-cryopreservation culture on human islet recovery and in vitro function.
Transplantation proceedings 1994;26(2):820.
1994: Jonathan R T Lakey; Garth L Warnock; Bhagirath Singh; Ray V Rajotte
Adjuvant immunotherapy with Bacillus Calmette-Guerin prevents recurrence of diabetes in islet grafts transplanted into NOD mice.
Transplantation proceedings 1994;26(2):736.
1994: Jonathan R T Lakey; T A Kizilisik; Ray V Rajotte; Ziliang Ao; Garth L Warnock; Norman M Kneteman
Prospective evaluation of two techniques for human pancreas recovery before islet isolation.
Transplantation proceedings 1994;26(2):589.
1993: W J Yakimets; Jonathan R T Lakey; Randall W Yatscoff; D Katyal; Ziliang Ao; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Prolongation of canine pancreatic islet allograft survival with combined rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
Transplantation 1993;56(6):1293-8.
1993: Gary D Lopaschuk; Jonathan R T Lakey; R Barr; Richard B Wambolt; Alan B R Thomson; M Thomas Clandinin; Ray V Rajotte
Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts.
Canadian journal of physiology and pharmacology 1993;71(12):896-903.
1993: M C Fabian; Jonathan R T Lakey; Ray V Rajotte; Norman M Kneteman
The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studies.
Transplantation 1993;56(5):1137-42.
1993: Ziliang Ao; K Matayoshi; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Survival and function of purified islets in the omental pouch site of outbred dogs.
Transplantation 1993;56(3):524-9.
1993: Jonathan R T Lakey; Garth L Warnock; R E Seelis; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
Human islet purification with discontinuous density gradients following cold storage of the pancreas.
Transplantation proceedings 1993;25(1 Pt 2):957-8.
1992: Garth L Warnock; Edmond A Ryan; Norman M Kneteman; Ziliang Ao; Jonathan R T Lakey; Ray V Rajotte
The natural history of transplantation of insulin-producing pancreatic islets into type I diabetic patients.
Transplantation proceedings 1992;24(6):3058.
1992: Jonathan R T Lakey; T Wang; Garth L Warnock; Bhagirath Singh; Ray V Rajotte
Prevention of recurrence of insulin-dependent diabetes mellitus in islet cell-transplanted diabetic NOD mice using adjuvant therapy.
Transplantation proceedings 1992;24(6):2848.
1992: M C Fabian; Jonathan R T Lakey; Ray V Rajotte; Norman M Kneteman
Rapamycin prolongs murine islet allograft survival.
Transplantation proceedings 1992;24(6):2842.
1992: Jonathan R T Lakey; Garth L Warnock; R E Seelis; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
A comparison of human islet purification with discontinuous density gradients of Ficoll prepared with Euro-Collins or medium 199 solution.
Transplantation proceedings 1992;24(6):2825.
1992: Ziliang Ao; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Collagenase digestion of canine pancreas by gentle automated dissociation in combination with ductal perfusion optimizes mass recovery of islets.
Transplantation proceedings 1992;24(6):2787.
1992: Ziliang Ao; K Matayoshi; W J Yakimets; Jonathan R T Lakey; D Katyal; Ray V Rajotte; Garth L Warnock
Comparison of dextran and Ficoll density gradients for purification of canine islets.
Transplantation proceedings 1992;24(6):2788.
1992: Jonathan R T Lakey; Alan B R Thomson; Monika Keelan; G L Lopaschuk; M Thomas Clandinin; C I Cheeseman; Ray V Rajotte
Dietary lipid content influences the clinical and intestinal adaptive responses to islet transplantation in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1992;19(4):149-64.
1991: Jonathan R T Lakey; Lawrence C H Wang; Ray V Rajotte
Optimal temperature in short-term hypothermic preservation of rat pancreas.
Transplantation 1991;51(5):977-81.