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Jonathan Lakey
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74
Rajotte, Ray
71
Shapiro, James
42
Warnock, Garth
40
Kneteman, Norman
31
Ryan, Edmond
24
Kin, Tatsuya
22
Korbutt, Gregory
22
Ao, Ziliang
17
Zieger, M A J
14
Critser, John
14
Paty, Breay
12
Cavanagh, TJ
12
Woods, Erik
11
Churchill, Thomas
11
Bigam, David
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All Publications
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2009: Reza Mirbolooki M; Taylor George E; Knutzen Victor K; Scharp David W; Willcourt Robin; Lakey Jonathan R T
Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications?
Medical hypotheses 2009;73(3):363-9.
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2008: Kin Tatsuya; O'Neil John J; Pawlick Rena; Korbutt Gregory S; Shapiro A M James; Lakey Jonathan R T
The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.
Artificial organs 2008;32(12):990-3.
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2008: Bikopoulos George; da Silva Pimenta Aurelio; Lee Simon C; Lakey Jonathan R; Der Sandy D; Chan Catherine B; Ceddia Rolando Bacis; Wheeler Michael B; Rozakis-Adcock Maria
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids.
The Journal of endocrinology 2008;196(3):455-64.
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2008: Suarez-Pinzon Wilma L; Lakey Jonathan R T; Rabinovitch Alex
Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice.
Cell transplantation 2008;17(6):631-40.
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2007: Campbell P M; Salam A; Ryan E A; Senior P; Paty B W; Bigam D; McCready T; Halpin A; Imes S; Al Saif F; Lakey J R T; Shapiro A M J
Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1242-8.
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2007: Kin T; Zhai X; Murdoch T B; Salam A; Shapiro A M James; Lakey Jonathan R T
Enhancing the success of human islet isolation through optimization and characterization of pancreas dissociation enzyme.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1233-41.
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2007: Kin Tatsuya; Johnson Paul R V; Shapiro A M James; Lakey Jonathan R T
Factors influencing the collagenase digestion phase of human islet isolation.
Transplantation 2007;83(1):7-12.
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2007: Lakey Jonathan R T; Kin Tatsuya; Warnock Garth L; Shapiro A M James; Tsapogas Panagiotis; Imes Sharleen; Korbutt Gregory S; Kneteman Norman M; Rajotte Ray V; Ryan Edmond A
Long-term graft function after allogeneic islet transplantation.
Cell transplantation 2007;16(4):441-6.
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2007: Kin Tatsuya; Rosichuk Shawn; Shapiro A M James; Lakey Jonathan R T
Detection of microbial contamination during human islet isolation.
Cell transplantation 2007;16(1):9-13.
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2007: Lakey Jonathan R T; Mirbolooki Mohammadreza; Rogers Christina; Mohr Jim
Demand for human allograft tissue in Canada.
Cell and tissue banking 2007;8(1):31-42.
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2007: Lakey Jonathan R T; Mirbolooki Mohammadreza; Rogers Christina; Mohr Jim
Supply of human allograft tissue in Canada.
Cell and tissue banking 2007;8(2):135-50.
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2006: Merani Shaheed; Schur Colleen; Truong Wayne; Knutzen Victor K; Lakey Jonathan R T; Anderson Colin C; Ricordi Camillo; Shapiro A M James
Compaction of islets is detrimental to transplant outcome in mice.
Transplantation 2006;82(11):1472-6.
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2006: Avila J G; Wang Y; Barbaro B; Gangemi A; Qi M; Kuechle J; Doubleday N; Doubleday M; Churchill T; Salehi P; Shapiro J; Philipson L H; Benedetti E; Lakey J R T; Oberholzer J
Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(12):2861-70.
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2006: Kin Tatsuya; Mirbolooki Mohammadreza; Salehi Payam; Tsukada Manabu; O'Gorman Doug; Imes Sharleen; Ryan Edmond A; Shapiro A M James; Lakey Jonathan R T
Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon.
Transplantation 2006;82(10):1286-90.
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2006: Meyer Steven R; Chiu Brian; Churchill Thomas A; Zhu Linfu; Lakey Jonathan R T; Ross David B
Comparison of aortic valve allograft decellularization techniques in the rat.
Journal of biomedical materials research. Part A 2006;79(2):254-62.
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2006: Fukazawa Takuya; Matsuoka Junji; Naomoto Yoshio; Nakai Toru; Durbin Mary L; Kojima Itaru; Lakey Jonathan R T; Tanaka Noriaki
Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures.
Experimental cell research 2006;312(17):3404-12.
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2006: Bussiere C T; Lakey J R T; Shapiro A M J; Korbutt G S
The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells.
Diabetologia 2006;49(10):2341-9.
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2006: Alsaif Faisal; Molinari Michele; Al-Masloom Abdulmuttalib; Lakey Jonathan R T; Kin Tatsuya; Shapiro A M James
Pancreatic islet autotransplantation with completion pancreatectomy in the management of uncontrolled pancreatic fistula after whipple resection for ampullary adenocarcinoma.
Pancreas 2006;32(4):430-1.
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2006: Paty Breay W; Senior Peter A; Lakey Jonathan R T; Shapiro A M James; Ryan Edmond A
Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects.
Diabetes technology & therapeutics 2006;8(2):165-73.
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2006: Hao Ergeng; Tyrberg Björn; Itkin-Ansari Pamela; Lakey Jonathan R T; Geron Ifat; Monosov Edward Z; Barcova Maria; Mercola Mark; Levine Fred
Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.
Nature medicine 2006;12(3):310-6.
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2006: Mirbolooki Mohammadreza; Lakey Jonathan R T
Oxygen and pancreas preservation.
Transplantation 2006;81(3):492; author reply 492-3.
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2006: Seeberger Karen L; Dufour Jannette M; Shapiro Andrew M James; Lakey Jonathan R T; Rajotte Ray V; Korbutt Gregory S
Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):141-53.
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2006: Miki Atsushi; Narushima Michiki; Okitsu Teru; Takeno Yuichi; Soto-Gutierrez Alejandro; Rivas-Carrillo Jorge David; Navarro-Alvarez Nalú; Chen Yong; Tanaka Kimiaki; Noguchi Hirofumi; Matsumoto Shinichi; Kohara Michinori; Lakey Jonathan R T; Kobayashi Eiji; Tanaka Noriaki; Kobayashi Naoya
Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts.
Cell transplantation 2006;15(4):325-34.
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2006: Lakey Jonathan R T; Mirbolooki Mohammadreza; Shapiro A M James
Current status of clinical islet cell transplantation.
Methods in molecular biology (Clifton, N.J.) 2006;333():47-104.
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2006: Miszta-Lane Helena; Mirbolooki Mohammadreza; James Shapiro A M; Lakey Jonathan R T
Stem cell sources for clinical islet transplantation in type 1 diabetes: embryonic and adult stem cells.
Medical hypotheses 2006;67(4):909-13.
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2006: Salehi Payam; Mirbolooki Mohammadreza; Kin Tatsuya; Tsujimura Toshiaki; Shapiro A M James; Churchill Thomas A; Lakey Jonathan R T
Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution.
Cell transplantation 2006;15(2):187-94.
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2006: Kin Tatsuya; Murdoch Travis B; Shapiro A M James; Lakey Jonathan R T
Estimation of pancreas weight from donor variables.
Cell transplantation 2006;15(2):181-5.
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2006: Swift Sue; Kin Tatsuya; Mirbolooki Mohammadreza; Wilson Richard; Lakey Jonathan R T
Comparison of cooling systems during islet purification.
Cell transplantation 2006;15(2):175-80.
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2005: Villiger P; Ryan E A; Owen R; O'Kelly K; Oberholzer J; Al Saif F; Kin T; Wang H; Larsen I; Blitz S L; Menon V; Senior P; Bigam D L; Paty B; Kneteman N M; Lakey J R T; Shapiro A M James
Prevention of bleeding after islet transplantation: lessons learned from a multivariate analysis of 132 cases at a single institution.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(12):2992-8.
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2005: Molinari Michele; Al-Saif Faisal; Ryan Edmond A; Lakey Jonathan R T; Senior Peter A; Paty Breay W; Bigam David L; Kneteman Norman M; Shapiro A M James
Sirolimus-induced ulceration of the small bowel in islet transplant recipients: report of two cases.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(11):2799-804.
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2005: O'Gorman D; Kin T; McGhee-Wilson D; Shapiro A M J; Lakey J R T
Multi-lot analysis of custom collagenase enzyme blend in human islet isolations.
Transplantation proceedings 2005;37(8):3417-9.
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2005: Narushima Michiki; Kobayashi Naoya; Okitsu Teru; Tanaka Yoshihito; Li Shun-Ai; Chen Yong; Miki Atsushi; Tanaka Kimiaki; Nakaji Shuhei; Takei Kohji; Gutierrez Alejandro Soto; Rivas-Carrillo Jorge David; Navarro-Alvarez Nalu; Jun Hee-Sook; Westerman Karen A; Noguchi Hirofumi; Lakey Jonathan R T; Leboulch Philippe; Tanaka Noriaki; Yoon Ji-Won
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Nature biotechnology 2005;23(10):1274-82.
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2005: Gustavson Stephanie M; Rajotte Ray V; Hunkeler David; Lakey Jonathan R T; Edgerton Dale S; Neal Doss W; Snead Wanda L; Penaloza Angelina R; Cherrington Alan D
Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(10):2368-77.
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2005: O'Gorman Doug; Kin Tatsuya; Murdoch Travis; Richer Brad; McGhee-Wilson Deborah; Ryan Edmond A; Shapiro James A M; Lakey Jonathan R T
The standardization of pancreatic donors for islet isolations.
Transplantation 2005;80(6):801-6.
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2005: Barnett Matthew J; Zhai Xiaojun; LeGatt Donald F; Cheng Siew Bang; Shapiro A M James; Lakey Jonathan R T
Quantitative assessment of collagenase blends for human islet isolation.
Transplantation 2005;80(6):723-8.
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2005: Emamaullee Juliet A; Rajotte Ray V; Liston Peter; Korneluk Robert G; Lakey Jonathan R T; Shapiro A M James; Elliott John F
XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.
Diabetes 2005;54(9):2541-8.
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2005: Meyer Steven R; Nagendran Jeevan; Desai Leena S; Rayat Gina R; Churchill Thomas A; Anderson Colin C; Rajotte Ray V; Lakey Jonathan R T; Ross David B
Decellularization reduces the immune response to aortic valve allografts in the rat.
The Journal of thoracic and cardiovascular surgery 2005;130(2):469-76.
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2005: Ryan Edmond A; Paty Breay W; Senior Peter A; Bigam David; Alfadhli Eman; Kneteman Norman M; Lakey Jonathan R T; Shapiro A M James
Five-year follow-up after clinical islet transplantation.
Diabetes 2005;54(7):2060-9.
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2005: Suarez-Pinzon Wilma L; Lakey Jonathan R T; Brand Stephen J; Rabinovitch Alex
Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass.
The Journal of clinical endocrinology and metabolism 2005;90(6):3401-9.
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2005: Shapiro A M James; Lakey Jonathan R T; Paty Breay W; Senior Peter A; Bigam David L; Ryan Edmond A
Strategic opportunities in clinical islet transplantation.
Transplantation 2005;79(10):1304-7.
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2005: Kin Tatsuya; Shapiro James; Ryan Edmond A; Lakey Jonathan R T
Islet isolation and transplantation from an annular pancreas: a case report.
JOP : Journal of the pancreas 2005;6(3):274-6.
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2005: Kin Tatsuya; Shapiro A M James; Lakey Jonathan R T
Pancreas divisum: a study of the cadaveric donor pancreas for islet isolation.
Pancreas 2005;30(4):325-7.
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2005: Meyer Steven R; Campbell Patricia M; Rutledge Jennifer M; Halpin Anne M; Hawkins Lois E; Lakey Jonathan R T; Rebeyka Ivan M; Ross David B
Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2005;27(4):554-60.
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2005: O'Gorman D; Kin T; Murdoch T; Richer B; McGhee-Wilson D; Ryan E; Shapiro A M J; Lakey J R T
The standardization of pancreatic donors for islet isolation.
Transplantation proceedings 2005;37(2):1309-10.
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2005: Ryan Edmond A; Paty Breay W; Senior Peter A; Lakey Jonathan R T; Bigam David; Shapiro A M James
Beta-score: an assessment of beta-cell function after islet transplantation.
Diabetes care 2005;28(2):343-7.
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2005: Shapiro A M James; Gallant Heather L; Hao Er Geng; Lakey Jonathan R T; McCready Tara; Rajotte Ray V; Yatscoff Randall W; Kneteman Norman M
The portal immunosuppressive storm: relevance to islet transplantation?
Therapeutic drug monitoring 2005;27(1):35-7.
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2005: Truong Wayne; Lakey Jonathan R T; Ryan Edmond A; Shapiro A M James
Clinical islet transplantation at the University of Alberta--the Edmonton experience.
Clinical transplants 2005;():153-72.
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2004: Street Cale N; Lakey Jonathan R T; Shapiro A M James; Imes Sharleen; Rajotte Ray V; Ryan Edmond A; Lyon James G; Kin Tatsuya; Avila Jose; Tsujimura Toshiaki; Korbutt Gregory S
Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.
Diabetes 2004;53(12):3107-14.
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2004: Kobayashi N; Arata T; Okitsu T; Ikeda H; Kobayashi K; Kosaka Y; Narushima M; Tanaka N; Lakey J R T
Transduction of human islets with the lentiviral vector.
Transplantation proceedings 2004;36(7):2203-4.
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2004: McDonald Charlotte G; Ryan Edmond A; Paty Breay W; Senior Peter A; Marshall Sally M; Lakey Jonathan R T; Shapiro A M James
Cross-sectional and prospective association between proinsulin secretion and graft function after clinical islet transplantation.
Transplantation 2004;78(6):934-7.
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2004: Tsujimura Toshiaki; Kuroda Yoshikazu; Avila Jose G; Kin Tatsuya; Oberholzer Jose; Shapiro A M James; Lakey Jonathan R T
Influence of pancreas preservation on human islet isolation outcomes: impact of the two-layer method.
Transplantation 2004;78(1):96-100.
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2004: Arata Takashi; Okitsu Teru; Fukazawa Takuya; Ikeda Hideaki; Kobayashi Kazuya; Yong Chen; Kosaka Yoshikazu; Narushima Michiki; Matsuoka Junji; Yamamoto Itaru; Tanaka Noriaki; Lakey Jonathan R T; Kobayashi Naoya
Maintenance of glucose-sensitive insulin secretion of cryopreserved human islets with University of Wisconsin solution and ascorbic acid-2 glucoside.
Artificial organs 2004;28(6):529-36.
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2004: Woods E J; Walsh C M; Sidner R A; Zieger M A J; Lakey J R T; Ricordi C; Critser J K
Improved in vitro function of islets using small intestinal submucosa.
Transplantation proceedings 2004;36(4):1175-7.
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2004: Woods E J; Walsh C M; Sidner R A; Zieger M A J; Mullin S; Lakey J R T; Ricordi C; Critser J K
Enhanced recovery of cryopreserved islets using SIS.
Transplantation proceedings 2004;36(4):1139-42.
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2004: Bhargava Ravi; Senior Peter A; Ackerman Thomas E; Ryan Edmond A; Paty Breay W; Lakey Jonathan R T; Shapiro A M James
Prevalence of hepatic steatosis after islet transplantation and its relation to graft function.
Diabetes 2004;53(5):1311-7.
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2004: Salehi Payam; Madsen Karen; Zhu Jay; Castillo Erika; Avila Jose; Lakey Jonathan R T; Churchill Thomas A
Alleviating ischemia-reperfusion injury in small bowel.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(5):728-37.
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2004: Street C N; Lakey J R T; Seeberger K; Helms L; Rajotte R V; Shapiro A M J; Korbutt G S
Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker.
The Journal of endocrinology 2004;180(2):213-25.
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2004: Street Cale N; Lakey Jonathan R T; Rajotte Ray V; Shapiro A M James; Kieffer Timothy J; Lyon James G; Kin Tatsuya; Korbutt Gregory S
Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.
The review of diabetic studies : RDS 2004;1(2):66-79.
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2004: Murdoch T B; McGhee-Wilson D; Shapiro A M J; Lakey J R T
Methods of human islet culture for transplantation.
Cell transplantation 2004;13(6):605-17.
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2004: Barnett M J; McGhee-Wilson D; Shapiro A M J; Lakey J R T
Variation in human islet viability based on different membrane integrity stains.
Cell transplantation 2004;13(5):481-8.
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2004: Young A T L; Moore R B; Murray A G; Mullen J C; Lakey J R T
Assessment of different transfection parameters in efficiency optimization.
Cell transplantation 2004;13(2):179-85.
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2004: Rose Natisha L; Palcic Monica M; Shapiro A M James; Lakey Jonathan R T
Endogenous pancreatic enzyme activity levels show no significant effect on human islet isolation yield.
Cell transplantation 2004;13(2):153-60.
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2004: Kobayashi Naoya; Okitsu Teru; Lakey Jonathan R T; Tanaka Noriaki
The current situation in human pancreatic islet transplantation: problems and prospects.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2004;7(1):1-8.
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2004: Tsujimura Toshiaki; Kuroda Yoshikazu; Churchill Thomas A; Avila Jose G; Kin Tatsuya; Shapiro A M James; Lakey Jonathan R T
Short-term storage of the ischemically damaged human pancreas by the two-layer method prior to islet isolation.
Cell transplantation 2004;13(1):67-73.
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2003: Shapiro A M James; Nanji Sulaiman A; Lakey Jonathan R T
Clinical islet transplant: current and future directions towards tolerance.
Immunological reviews 2003;196():219-36.
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2003: Rafael Ehab; Ryan Edmond A; Paty Breay W; Oberholzer Jose; Imes Sharleen; Senior Peter; McDonald Charlotte; Lakey Jonathan R T; Shapiro A M James
Changes in liver enzymes after clinical islet transplantation.
Transplantation 2003;76(9):1280-4.
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2003: Young A T L; Lakey J R T; Murray A G; Mullen J C; Moore R B
In vitro senescence occurring in normal human endothelial cells can be rescued by ectopic telomerase activity.
Transplantation proceedings 2003;35(7):2483-5.
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2003: Tsujimura T; Kuroda Y; Avila J G; Kin T; Churchill T A; Shapiro A M J; Lakey J R T
Resuscitation of the ischemically damaged human pancreas by the two-layer method prior to islet isolation.
Transplantation proceedings 2003;35(7):2461-2.
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2003: Rose N L; Palcic M M; Shapiro A M J; Lakey J R T
An evaluation of endogenous pancreatic enzyme levels following enzymatic digestion.
Transplantation proceedings 2003;35(7):2458-60.
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2003: Rose N L; Palcic M M; Shapiro A M J; Lakey J R T
An evaluation of the activation of endogenous pancreatic enzymes during human islet isolations.
Transplantation proceedings 2003;35(7):2455-7.
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2003: Owen Richard J T; Ryan Edmond A; O'Kelly Kevin; Lakey Jonathan R T; McCarthy Mairin C; Paty Breay W; Bigam David L; Kneteman Norman M; Korbutt Gregory S; Rajotte Ray V; Shapiro A M James
Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.
Radiology 2003;229(1):165-70.
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2003: Lakey Jonathan R T; Burridge Philip W; Shapiro A M James
Technical aspects of islet preparation and transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2003;16(9):613-32.
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2003: Rose Natisha L; Palcic Monica M; Lakey Jonathan R T
An evaluation of endogenous pancreatic enzyme levels after human islet isolation.
Pancreas 2003;27(2):167-73.
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2003: Zhu Jay Z J; Castillo Erika G; Salehi Payam; Avila Jose; Lakey Jonathan R T; Churchill Thomas A
A novel technique of hypothermic luminal perfusion for small bowel preservation.
Transplantation 2003;76(1):71-6.
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2003: Rose Natisha L; Palcic Monica M; Helms Lisa M H; Lakey Jonathan R T
Evaluation of Pefabloc as a serine protease inhibitor during human-islet isolation.
Transplantation 2003;75(4):462-6.
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2003: Lu W-T; Lakey J R T; Juang J-H; Hsu B R-S; Rajotte R V
Effect of trypsin inhibitor on islet isolation from fresh and cold preserved rat pancreas.
Transplantation proceedings 2003;35(1):488-9.
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2003: Avila J G; Tsujimura T; Oberholzer J; Churchill T; Salehi P; Shapiro A M James; Lakey J R T
Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure.
Cell transplantation 2003;12(8):877-81.
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2003: Oberholzer José; Shapiro A M; Lakey Jonathan R; Ryan Edmond A; Rajotte Ray V; Korbutt Gregory S; Morel Philippe; Kneteman Norman M
Current status of islet cell transplantation.
Advances in surgery 2003;37():253-82.
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2003: Lakey Jonathan R T; Helms Lisa M H; Moser Gabrielle; Lix Bruce; Slupsky Carolyn M; Rebeyka Ivan M; Sykes Brian D; McGann Locksley E
Dynamics of cryoprotectant permeation in porcine heart valve leaflets.
Cell transplantation 2003;12(2):123-8.
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2002: Lakey Jonathan R T; Tsujimura Toshiaki; Shapiro A M James; Kuroda Yoshikazu
Preservation of the human pancreas before islet isolation using a two-layer (UW solution-perfluorochemical) cold storage method.
Transplantation 2002;74(12):1809-11.
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2002: Tsujimura Toshiaki; Kuroda Yoshikazu; Kin Tatsuya; Avila Jose G; Rajotte Ray V; Korbutt Gregory S; Ryan Edmond A; Shapiro A M James; Lakey Jonathan R T
Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method.
Transplantation 2002;74(12):1687-91.
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2002: Burridge P W; Shapiro A M J; Ryan E A; Lakey J R T
Future trends in clinical islet transplantation.
Transplantation proceedings 2002;34(8):3347-8.
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2002: Shapiro A M James; Geng Hao Er; Lakey Jonathan R T; Finegood Diane T; Rajotte Ray V; Kneteman Norman M
Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts.
Transplantation 2002;74(11):1522-8.
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2002: Beattie Gillian M; Montgomery Anthony M P; Lopez Ana D; Hao Ergeng; Perez Brandon; Just Margaret L; Lakey Jonathan R T; Hart Marquis E; Hayek Alberto
A novel approach to increase human islet cell mass while preserving beta-cell function.
Diabetes 2002;51(12):3435-9.
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2002: Paty Breay W; Ryan Edmond A; Shapiro A M James; Lakey Jonathan R T; Robertson R Paul
Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence.
Diabetes 2002;51(12):3428-34.
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2002: Lu W-T; Lakey J R T; Juang J-H; Hsu B R-S; Rajotte R V
Effect of pefabloc on islet isolation from cold preserved rat pancreas.
Transplantation proceedings 2002;34(7):2700-1.
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2002: MacDonald Patrick E; Wang Guotang; Tsuk Sharon; Dodo Chikvashvili; Kang Youhou; Tang Lan; Wheeler Michael B; Cattral Mark S; Lakey Jonathan R T; Salapatek Anne Marie F; Lotan Ilana; Gaisano Herbert Y
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
Molecular endocrinology (Baltimore, Md.) 2002;16(11):2452-61.
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2002: Casey John J; Lakey Jonathan R; Ryan Edmond A; Paty Breay W; Owen Richard; O'Kelly Kevin; Nanji Sulaiman; Rajotte Ray V; Korbutt Gregory S; Bigam David; Kneteman Norman N; Shapiro A M
Portal venous pressure changes after sequential clinical islet transplantation.
Transplantation 2002;74(7):913-5.
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2002: Geisler John G; Zawalich Walter; Zawalich Kathleen; Lakey Jonathan R T; Stukenbrok Hans; Milici Anthony J; Soeller Walter C
Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide.
Diabetes 2002;51(7):2158-69.
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2002: Ryan Edmond A; Lakey Jonathan R T; Paty Breay W; Imes Sharleen; Korbutt Gregory S; Kneteman Norman M; Bigam David; Rajotte Ray V; Shapiro A M James
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Diabetes 2002;51(7):2148-57.
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2002: Lakey Jonathan R T; Kneteman Norman M; Rajotte Ray V; Wu Douglas C; Bigam David; Shapiro A M James
Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability.
Transplantation 2002;73(7):1106-10.
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2002: Rose Natisha L; Palcic Monica M; Lakey Jonathan R T
Evaluating the effect of serine proteases on collagenase activity during human islet isolation.
Cell transplantation 2002;11(8):821-6.
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2002: Young A T L; Lakey J R T; Murray A G; Moore R B
Gene therapy: a lipofection approach for gene transfer into primary endothelial cells.
Cell transplantation 2002;11(6):573-82.
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2001: Shapiro A M; Ryan E A; Lakey J R
Diabetes. Islet cell transplantation.
Lancet 2001;358 Suppl():S21.
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2001: Lakey J R; Suarez-Pinzon W L; Strynadka K; Korbutt G S; Rajotte R V; Mabley J G; Szabó C; Rabinovitch A
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(12):1683-92.
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2001: Shapiro A M; Ryan E A; Lakey J R
Clinical islet transplant--state of the art.
Transplantation proceedings 2001;33(7-8):3502-3.
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2001: Ryan E A; Lakey J R; Shapiro A M
Clinical results after islet transplantation.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2001;49(6):559-62.
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2001: Lakey J R; Anderson T J; Rajotte R V
Novel approaches to cryopreservation of human pancreatic islets.
Transplantation 2001;72(6):1005-11.
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2001: Lakey J R; Helms L M; Kin T; Korbutt G S; Rajotte R V; Shapiro A M; Warnock G L
Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.
Transplantation 2001;72(4):565-70.
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2001: Mercer D F; Schiller D E; Elliott J F; Douglas D N; Hao C; Rinfret A; Addison W R; Fischer K P; Churchill T A; Lakey J R; Tyrrell D L; Kneteman N M
Hepatitis C virus replication in mice with chimeric human livers.
Nature medicine 2001;7(8):927-33.
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2001: Shapiro A M; Ryan E A; Lakey J R
Pancreatic islet transplantation in the treatment of diabetes mellitus.
Best practice & research. Clinical endocrinology & metabolism 2001;15(2):241-64.
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2001: Shapiro A M; Hao E G; Lakey J R; Yakimets W J; Churchill T A; Mitlianga P G; Papadopoulos G K; Elliott J F; Rajotte R V; Kneteman N M
Novel approaches toward early diagnosis of islet allograft rejection.
Transplantation 2001;71(12):1709-18.
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2001: Ryan E A; Lakey J R; Rajotte R V; Korbutt G S; Kin T; Imes S; Rabinovitch A; Elliott J F; Bigam D; Kneteman N M; Warnock G L; Larsen I; Shapiro A M
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.
Diabetes 2001;50(4):710-9.
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2001: Lakey J R; Young A T; Pardue D; Calvin S; Albertson T E; Jacobson L; Cavanagh T J
Nonviral transfection of intact pancreatic islets.
Cell transplantation 2001;10(8):697-708.
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2001: Fedorow C; McGann L E; Korbutt G S; Rayat G R; Rajotte R V; Lakey J R
Osmotic and cryoprotectant permeation characteristics of islet cells isolated from the newborn pig pancreas.
Cell transplantation 2001;10(7):651-9.
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2001: Lakey J R; Rajotte R V; Fedorow C A; Taylor M J
Islet cryopreservation using intracellular preservation solutions.
Cell transplantation 2001;10(7):583-9.
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2000: Shapiro A M; Lakey J R; Ryan E A; Korbutt G S; Toth E; Warnock G L; Kneteman N M; Rajotte R V
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
The New England journal of medicine 2000;343(4):230-8.
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2000: Shapiro A M; Lakey J R
Future trends in islet cell transplantation.
Diabetes technology & therapeutics 2000;2(3):449-52.
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1999: Woods E J; Liu J; Zieger M A; Lakey J R; Critser J K
The effects of microencapsulation on pancreatic islet osmotically induced volumetric response.
Cell transplantation 1999;8(6):699-708.
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1999: Lakey J R; Aspinwall C A; Cavanagh T J; Kennedy R T
Secretion from islets and single islet cells following cryopreservation.
Cell transplantation 1999;8(6):691-8.
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1999: Woods E J; Liu J; Zieger M A; Lakey J R; Critser J K
Water and cryoprotectant permeability characteristics of isolated human and canine pancreatic islets.
Cell transplantation 1999;8(5):549-59.
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1999: Warnock G L; Lakey J R
Cryopreservation of human islets of Langerhans.
Transplantation 1999;68(5):597-8.
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1999: Lakey J R; Warnock G L; Shapiro A M; Korbutt G S; Ao Z; Kneteman N M; Rajotte R V
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Cell transplantation 1999;8(3):285-92.
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1999: Zieger M A; Woods E J; Lakey J R; Liu J; Critser J K
Osmotic tolerance limits of canine pancreatic islets.
Cell transplantation 1999;8(3):277-84.
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1998: Lakey J R; Cavanagh T J; Zieger M A
A prospective comparison of discontinuous EuroFicoll and EuroDextran gradients for islet purification.
Cell transplantation 1998;7(5):479-87.
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1998: Cattral M S; Lakey J R; Warnock G L; Kneteman N M; Rajotte R V
Effect of cryopreservation on the survival and function of murine islet isografts and allografts.
Cell transplantation 1998;7(4):373-9.
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1998: Lakey J R; Cavanagh T J; Zieger M A; Wright M
Evaluation of a purified enzyme blend for the recovery and function of canine pancreatic islets.
Cell transplantation 1998;7(4):365-72.
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1998: Lakey J R
Examination of microbiological contamination rates following bacterial culture and incubation for 2, 7, and 14 days.
Transplantation proceedings 1998;30(2):664.
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1998: Shapiro A M; Hao E; Lakey J R; Elliott J F; Rajotte R V; Kneteman N M
Development of diagnostic markers for islet allograft rejection.
Transplantation proceedings 1998;30(2):647.
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1998: Lakey J R; Cavanagh T J; Zieger M A; Albertson T E; Dwulet F; Wright M J; Fetterhoff T J
Evaluation of a purified enzyme blend for the recovery and in vitro function of isolated canine islets.
Transplantation proceedings 1998;30(2):590-1.
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1998: Shapiro A M; Hao E; Lakey J R; Finegood D; Rajotte R V; Kneteman N M
Diabetogenic synergism in canine islet autografts from cyclosporine and steroids in combination.
Transplantation proceedings 1998;30(2):527.
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1998: Lakey J R; Pardue D; Calvin S; Albertson T E; Cavanagh T J; Jacobsen L
Nonviral transfection of isolated islets of Langerhans.
Transplantation proceedings 1998;30(2):469.
-
1998: Woods E J; Lakey J R; Zieger M A; Liu J; Critser J K
Osmotic responses of isolated canine islets to novel cryoprotectants.
Transplantation proceedings 1998;30(2):388-9.
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1998: Lakey J R; Troendle J; Zieger M A; Geary W A; Voytek S; Critser J K
Improved islet survival and in vitro function using small intestinal submucosa.
Transplantation proceedings 1998;30(2):383.
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1998: Lakey J R; Aspinwall C A; Cavanagh T J; Kennedy R T
Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques.
Transplantation proceedings 1998;30(2):382.
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1998: Lakey J R; Zieger M A; Woods E J; Critser J K; Wright J R
Permeability characteristics of isolated Brockmann bodies.
Transplantation proceedings 1998;30(2):380.
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1998: Cavanagh T J; Lakey J R; Wright M J; Albertson T; Wile K; Fetterhoff T J
Identification of a pig strain with maximal islet mass.
Transplantation proceedings 1998;30(2):368.
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1998: Cavanagh T J; Lakey J R; Dwulet F; Wright M J; Wile K; Albertson T; Fetterhoff T
Improved pig islet yield and post-culture recovery using Liberase PI purified enzyme blend.
Transplantation proceedings 1998;30(2):367.
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1998: Lakey J R; Warnock G L; Ao Z; Shapiro A M; Korbutt G; Kneteman N; Rajotte R V
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Transplantation proceedings 1998;30(2):359.
-
1998: Lakey J R; Cavanagh T J; Zieger M A; Critser J K
A prospective comparison of discontinuous Euroficoll and Eurodextran gradients for islet purification.
Transplantation proceedings 1998;30(2):348.
-
1998: Lakey J R; Smith M E; Fetterhoff T J; Cavanagh T J; Wright M J; Dwulet F E
Sterile filtration of collagenase solution: effect of filter membrane composition on enzyme recovery.
Transplantation proceedings 1998;30(2):347.
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1997: Woods E J; Zieger M A; Lakey J R; Liu J; Critser J K
Osmotic characteristics of isolated human and canine pancreatic islets.
Cryobiology 1997;35(2):106-13.
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1997: Liu J; Zieger M A; Lakey J R; Woods E J; Critser J K
The determination of membrane permeability coefficients of canine pancreatic islet cells and their application to islet cryopreservation.
Cryobiology 1997;35(1):1-13.
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1997: Lakey J R; Zieger M A; Woods E J; Liu J; Critser J K
Hypoosmotic exposure of canine pancreatic digest as a means to purify islet tissue.
Cell transplantation 1997;6(4):423-8.
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1997: Woods E J; Lakey J R; Zieger M A; Liu J; Nelson D; Critser J K
Permeability characteristics of microencapsulated pancreatic islets.
Transplantation proceedings 1997;29(4):2148.
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1997: Liu J; Zieger M A; Lakey J R; Woods E; Critser J K
Water and DMSO permeability at 22 degrees C, 5 degrees C, and -3 degrees C for human pancreatic islet cells.
Transplantation proceedings 1997;29(4):1987.
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1997: Lakey J R; Warnock G L; Rajotte R V
Optimization of removal of cryoprotectant from frozen-thawed islets.
Transplantation proceedings 1997;29(4):1986.
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1997: Lakey J R; Warnock G L; Brierton M; Ao Z; Hering B J; London N; Ricordi C; Corbin F; Rajotte R V
Development of an automated computer-controlled islet isolation system.
Transplantation proceedings 1997;29(4):1956.
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1997: Cavanagh T J; Lakey J R; Wright M J; Fetterhoff T; Wile K
Crude collagenase loses islet-isolating efficacy regardless of storage conditions.
Transplantation proceedings 1997;29(4):1942-4.
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1997: Lakey J R; Warnock G L; Rajotte R V
Comparison of methods used for the removal of DMSO following cryopreservation and the development of an automated protocol.
Cell transplantation 1997;6(2):163-72.
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1997: Lakey J R; Warnock G L; Brierton M; Ao Z; Hering B J; London N J; Ricordi C; Corbin F; Rajotte R V
Development of an automated computer-controlled islet isolation system.
Cell transplantation 1997;6(1):47-57.
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1996: Lakey J R; Warnock G L; Ao Z; Rajotte R V
Bulk cryopreservation of isolated islets of Langerhans.
Cell transplantation 1996;5(3):395-404.
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1996: Langman L J; Shapiro A M; Lakey J R; LeGatt D F; Kneteman N M; Yatscoff R W
Pharmacodynamic assessment of mycophenolic acid in a canine model.
Transplantation proceedings 1996;28(2):934-6.
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1996: Lakey J R; Yatscoff R W; Koshal A; Rajotte R V
Prolongation of concordant islet xenografts with leflunomide.
Transplantation proceedings 1996;28(2):816.
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1996: Lakey J R; Warnock G L; Rajotte R V; Suarez-Alamazor M E; Ao Z; Shapiro A M; Kneteman N M
Variables in organ donors that affect the recovery of human islets of Langerhans.
Transplantation 1996;61(7):1047-53.
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1996: Kneteman N M; Lakey J R; Wagner T; Finegood D
The metabolic impact of rapamycin (sirolimus) in chronic canine islet graft recipients.
Transplantation 1996;61(8):1206-10.
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1996: Lakey J R; Warnock G L; Rajotte R V
Intrathymic transplantation of fresh and cryopreserved islets for the induction of a state of unresponsiveness in rats.
Transplantation 1996;61(3):506-8.
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1996: Langman L J; Shapiro A M; Lakey J R; LeGatt D F; Kneteman N M; Yatscoff R W
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measurement of inosine monophosphate dehydrogenase activity in a canine model.
Transplantation 1996;61(1):87-92.
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1996: Tuitoek P J; Lakey J R; Rajotte R V; Basu T K
Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1996;66(2):101-5.
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1995: Lakey J R; Singh B; Warnock G L; Elliott J F; Rajotte R V
Dose dependence of bacillus Calmette-Guerin on the prevention of autoimmune diabetes in syngeneic islet transplantation.
Transplantation proceedings 1995;27(6):3413.
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1995: Rajotte R V; Ao Z; Korbutt G S; Lakey J R; Flashner M; Colby C B; Warnock G L
Cryopreservation of microencapsulated canine islets.
Transplantation proceedings 1995;27(6):3389.
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1995: Cattral M S; Lakey J R; Warnock G L; Kneteman N M; Rajotte R V
Effect of cryopreservation on islet recovery and in vivo function.
Transplantation proceedings 1995;27(6):3336.
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1995: Lakey J R; Ao Z; Warnock G L; Korbutt G S; Flashner M; Colby C B; Rajotte R V
Recovery and in vivo function of canine islets cryopreserved in a freezer bag.
Transplantation proceedings 1995;27(6):3266.
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1995: Lakey J R; Warnock G L; Rajotte R V; Ao Z; Suarez-Almazor M E; Shapiro A M; Kneteman N M
Factors in cadaveric donors that affect recovery of human islets of Langerhans.
Transplantation proceedings 1995;27(6):3265.
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1995: Kneteman N M; Lakey J R; Wagner T; Finegood D
Beneficial metabolic impact of the novel immunosuppressant rapamycin in chronic canine islet autograft recipients.
Transplantation proceedings 1995;27(6):3213.
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1995: Warnock G I; Tsapogas P; Ryan E A; Lakey J R; Korbutt G; Kneteman N M; Ao Z; Rabinovitch A; Rajotte R V
Natural history of insulin independence after transplantation of multidonor cryopreserved pancreatic islets in type 1 diabetic humans.
Transplantation proceedings 1995;27(6):3159-60.
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1995: Lakey J R; Singh B; Warnock G L; Elliott J F; Rajotte R V
Long-term survival of syngeneic islet grafts in BCG-treated diabetic NOD mice can be reversed by cyclophosphamide.
Transplantation 1995;59(12):1751-3.
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1995: Lakey J R; Rajotte R V; Warnock G L
Microbial surveillance of human islet isolation, in vitro culture, and cryopreservation.
Clinical and investigative medicine. Médecine clinique et experimentale 1995;18(3):168-76.
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1995: Shapiro A M; Lakey J R; Rajotte R V; Warnock G L; Friedlich M S; Jewell L D; Kneteman N M
Portal vein thrombosis after transplantation of partially purified pancreatic islets in a combined human liver/islet allograft.
Transplantation 1995;59(7):1060-3.
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1995: Lakey J R; Rajotte R V; Warnock G L; Kneteman N M
Human pancreas preservation prior to islet isolation. Cold ischemic tolerance.
Transplantation 1995;59(5):689-94.
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1994: Gainer A L; Lakey J R; Rajotte R V; Warnock G L
Survival and function of human islets subjected to gamma-radiation.
Transplantation proceedings 1994;26(6):3457.
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1994: Warnock G L; Lakey J R; Ao Z; Rajotte R V
Tissue banking of cryopreserved islets for clinical islet transplantation.
Transplantation proceedings 1994;26(6):3438.
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1994: Lakey J R; Rajotte R V; Warnock G L; Kneteman N M
Cold ischemic tolerance of human pancreas: assessment of islet recovery and in vitro function.
Transplantation proceedings 1994;26(6):3416.
-
1994: Lakey J R; Warnock G L; Rajotte R V
Conditions for the induction of unresponsiveness to cryopreserved islet allografts with intrathymic islets.
Transplantation proceedings 1994;26(6):3313.
-
1994: Lakey J R; Warnock G L; Kneteman N M; Ao Z; Rajotte R V
Development of a method for bulk cryopreservation of purified canine islets.
Transplantation proceedings 1994;26(6):3300.
-
1994: Kneteman N M; Lakey J R; Kizilisik T A; Ao Z; Warnock G L; Rajotte R V
Cadaver pancreas recovery technique. Impact on islet recovery and in vitro function.
Transplantation 1994;58(10):1114-9.
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1994: Lakey J R; Singh B; Warnock G L; Rajotte R V
BCG immunotherapy prevents recurrence of diabetes in islet grafts transplanted into spontaneously diabetic NOD mice.
Transplantation 1994;57(8):1213-7.
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1994: Lakey J R; Rajotte R V; Taylor G D; Kirkland T; Warnock G L
Microbial studies of a tissue bank of cryopreserved human islet cells.
Transplantation proceedings 1994;26(2):827.
-
1994: Lakey J R; Warnock G L; Kneteman N M; Ao Z; Rajotte R V
Effects of pre-cryopreservation culture on human islet recovery and in vitro function.
Transplantation proceedings 1994;26(2):820.
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1994: Lakey J R; Warnock G L; Singh B; Rajotte R V
Adjuvant immunotherapy with Bacillus Calmette-Guerin prevents recurrence of diabetes in islet grafts transplanted into NOD mice.
Transplantation proceedings 1994;26(2):736.
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1994: Lakey J R; Kizilisik T A; Rajotte R V; Ao Z; Warnock G L; Kneteman N M
Prospective evaluation of two techniques for human pancreas recovery before islet isolation.
Transplantation proceedings 1994;26(2):589.
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1993: Yakimets W J; Lakey J R; Yatscoff R W; Katyal D; Ao Z; Finegood D T; Rajotte R V; Kneteman N M
Prolongation of canine pancreatic islet allograft survival with combined rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
Transplantation 1993;56(6):1293-8.
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1993: Lopaschuk G D; Lakey J R; Barr R; Wambolt R; Thomson A B; Clandinin M T; Rajotte R V
Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts.
Canadian journal of physiology and pharmacology 1993;71(12):896-903.
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1993: Fabian M C; Lakey J R; Rajotte R V; Kneteman N M
The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studies.
Transplantation 1993;56(5):1137-42.
-
1993: Ao Z; Matayoshi K; Lakey J R; Rajotte R V; Warnock G L
Survival and function of purified islets in the omental pouch site of outbred dogs.
Transplantation 1993;56(3):524-9.
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1993: Lakey J R; Warnock G L; Seelis R E; Ao Z; Kneteman N M; Rajotte R V
Human islet purification with discontinuous density gradients following cold storage of the pancreas.
Transplantation proceedings 1993;25(1 Pt 2):957-8.
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1992: Warnock G L; Ryan E A; Kneteman N M; Ao Z; Lakey J R; Rajotte R V
The natural history of transplantation of insulin-producing pancreatic islets into type I diabetic patients.
Transplantation proceedings 1992;24(6):3058.
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1992: Lakey J R; Wang T; Warnock G L; Singh B; Rajotte R V
Prevention of recurrence of insulin-dependent diabetes mellitus in islet cell-transplanted diabetic NOD mice using adjuvant therapy.
Transplantation proceedings 1992;24(6):2848.
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1992: Fabian M C; Lakey J R; Rajotte R V; Kneteman N M
Rapamycin prolongs murine islet allograft survival.
Transplantation proceedings 1992;24(6):2842.
-
1992: Lakey J R; Warnock G L; Seelis R E; Ao Z; Kneteman N M; Rajotte R V
A comparison of human islet purification with discontinuous density gradients of Ficoll prepared with Euro-Collins or medium 199 solution.
Transplantation proceedings 1992;24(6):2825.
-
1992: Ao Z; Lakey J R; Rajotte R V; Warnock G L
Collagenase digestion of canine pancreas by gentle automated dissociation in combination with ductal perfusion optimizes mass recovery of islets.
Transplantation proceedings 1992;24(6):2787.
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1992: Ao Z; Matayoshi K; Yakimets W J; Lakey J R; Katyal D; Rajotte R V; Warnock G L
Comparison of dextran and Ficoll density gradients for purification of canine islets.
Transplantation proceedings 1992;24(6):2788.
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1992: Lakey J R; Thomson A B; Keelan M; Lopaschuk G L; Clandinin M T; Cheeseman C I; Rajotte R V
Dietary lipid content influences the clinical and intestinal adaptive responses to islet transplantation in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1992;19(4):149-64.
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1991: Lakey J R; Wang L C; Rajotte R V
Optimal temperature in short-term hypothermic preservation of rat pancreas.
Transplantation 1991;51(5):977-81.
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