FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kit Lam

Research Profile

Procedures

Chemicals & Drugs

Living Beings

Anatomy

Tumor Cell Line

Genes & Molecular Sequences

Phenomena

Protein Binding

Concepts & Ideas

Occupations

Drug Design

Objects

Microspheres

Co-author Network

Publications

TOP 3
Pappanaicken R Kumaresan; Kit S Lam; Edmond Y Lau; Ruiwu Liu; Sridevi Devaraj; Wenzhe Huang; Ishwarlal Jialal
Synthesis and characterization of a novel inhibitor of C-reactive protein-mediated proinflammatory effects.
Yuzhe Ding; Eric Huang; Kit S Lam; Tingrui Pan
Microfluidic impact printer with interchangeable cartridges for versatile non-contact multiplexed micropatterning.
Patrick S C Leung; Phornnop Naiyanetr; Jinjun Wang; Thomas P Kenny; Mark J Kurth; Kit S Lam; M Eric Gershwin
Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kit Lam (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Pappanaicken R Kumaresan; Kit S Lam; Edmond Y Lau; Ruiwu Liu; Sridevi Devaraj; Wenzhe Huang; Ishwarlal Jialal
Synthesis and characterization of a novel inhibitor of C-reactive protein-mediated proinflammatory effects.
Metabolic syndrome and related disorders 2013;11(3):177-84.
2013: Yuzhe Ding; Eric Huang; Kit S Lam; Tingrui Pan
Microfluidic impact printer with interchangeable cartridges for versatile non-contact multiplexed micropatterning.
Lab on a chip 2013;13(10):1902-10.
2013: Patrick S C Leung; Phornnop Naiyanetr; Jinjun Wang; Thomas P Kenny; Mark J Kurth; Kit S Lam; M Eric Gershwin
Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA.
Journal of autoimmunity 2013;41():79-86.
2013: Meiye Wu; Chung-Yan Koh; Kit S Lam; Matthew Piccini; Anup K Singh
Single cell microRNA analysis using microfluidic flow cytometry.
PloS one 2013;8(1):e55044.
2013: Long Ye; Yoko K Takada; Tiffany Dickerson; Masaaki Fujita; Handeep Kaur; John M Knapp; Mark J Kurth; Kit S Lam; Ruiwu Liu; Neil E Schore; Yoshikazu Takada
Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3.
Bioorganic & medicinal chemistry letters 2013;23(1):340-5.
2012: Nadire Duru; Angela Eldridge; Ming Fan; Kit S Lam; Demet Candas; Brett Chromy; Shiyong Li; Hsin-Chen Liu; Cheikh Menaa; Danupon Nantajit; Douglas R Spitz; Yunfei Wen; Max S Wicha; Kai Xiao; Jian Jian Li
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6634-47.
2012: Fan Yang; Richard Jordan; Randall Kramer; Ruiwu Liu; Wenwu Xiao; Kit S Lam
Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.
Journal of the California Dental Association 2012;40(12):939-43.
2012: Joyce Lee; Kit S Lam
Perspectives on clinical translation of smart nanotherapeutics.
Therapeutic delivery 2012;3(12):1359-62.
2012: Yuanpei Li; Juntao Luo; John C Voss; Wenwu Xiao; Madhu S Budamagunta; Kit S Lam
Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins.
ACS nano 2012;6(11):9485-95.
2012: Wenchang Guo; Wenzhe Huang; Kit S Lam; Jixian Li; Ruiwu Liu; Ai-Hong Ma; Anthony Martinez; Emanual Maverakis; Anisha Mazloom; Jinying Ning; Yoko Ono; Eduardo Sanchez; Yan Wang; Hsing-Jien Kung
Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.
Molecular pharmacology 2012;82(5):938-47.
2012: Patrick S C Leung; Ross L Coppel; Mark J Kurth; Kit S Lam; M Eric Gershwin
Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?
Trends in molecular medicine 2012;18(10):577-82.
2012: Hongyong Zhang; Weixin Zhao; Sebastian Wachsmann-Hogiu; Yanchun Wang; Paul Henderson; Kit S Lam; Yuanpei Li; Juntao Luo; Chong-Xian Pan
Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(7):1116-24.
2012: Hongyong Zhang; Xiaobing Wang; Olulanu H Aina; James A Bassuk; Ralph W deVere White; Christopher P Evans; Paul Henderson; Kit S Lam; Primo Lara; Chong-Xian Pan
Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach.
Urologic oncology 2012;30(5):635-45.
2012: Xiaowen Hu; Azadeh Kheirolomoom; Dustin E Kruse; Kit S Lam; Lisa M Mahakian; Julie R Beegle; Katherine W Ferrara
Insonation of targeted microbubbles produces regions of reduced blood flow within tumor vasculature.
Investigative radiology 2012;47(7):398-405.
2012: Jason Kato; Joyce S Lee; Yuanpei Li; Juntao Luo; Robert T O'Donnell; Joseph M Tuscano; Kai Xiao; Kit S Lam
Disulfide cross-linked micelles for the targeted delivery of vincristine to B-cell lymphoma.
Molecular pharmaceutics 2012;9(6):1727-35.
2012: Monica Shokeen; Jessica M Wilson; Alexander Zheleznyak; Riccardo Ferdani; Majiong Jiang; Kit S Lam; Ruiwu Liu; Julie K Schwarz; Carolyn J Anderson
Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(5):779-86.
2012: Kai Xiao; Li Xing; Holland R Cheng; Tiffany Dong; Gabriel Fung; Abby M Gonik; Joyce S Lee; Yuanpei Li; Juntao Luo; Eduardo Sanchez; Kit S Lam
"OA02" peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo.
Cancer research 2012;72(8):2100-10.
2012: Yuanpei Li; Juntao Luo; Harry P Tseng; Kai Xiao; Wenwu Xiao; Lorenzo Berti; Gabriel Fung; Kit S Lam
Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols.
Angewandte Chemie (International ed. in English) 2012;51(12):2864-9.
2012: Min Guan; Junjing Jia; Kit S Lam; Ruiwu Liu; Liping Meng; Jan A Nolta; Brian Panganiban; Robert O Ritchie; Mohammad Shahnazari; Wei Yao; Ping Zhou; Nancy E Lane
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass.
Nature medicine 2012;18(3):456-62.
2012: Allison L Zwingenberger; Xiucui Chen; Michael S Kent; Changying Shi; Sandra L Taylor; Kit S Lam
Affinity of the alpha4-beta1 integrin-targeting peptide LLP2A to canine lymphoma.
Veterinary immunology and immunopathology 2012;145(1-2):298-304.
2012: Tzu-Yin Lin; Juntao Luo; Hongyong Zhang; Ralph W deVere White; Tingjuan Gao; Kit S Lam; Primo Lara; Yuanpei Li; Chong-Xian Pan
Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer.
International journal of nanomedicine 2012;7():2793-804.
2012: Wenwu Xiao; Simon R Cherry; Paul Henderson; Teesta Jain; Juntao Luo; John W Riggs; Douglas Rowland; Harry P Tseng; Kit S Lam
Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer.
International journal of nanomedicine 2012;7():1587-97.
2012: Allison L Zwingenberger; Ruiwu Liu; Sandra L Taylor; Erik R Wisner; Xiucui Chen; Sally J DeNardo; Michael S Kent; David L Kukis; Kit S Lam
In-vivo biodistribution and safety of 99mTc-LLP2A-HYNIC in canine non-Hodgkin lymphoma.
PloS one 2012;7(4):e34404.
2011: Phornnop Naiyanetr; Janice Pfeiff; Roman Reiger; Marcos López-Hoyos; Liping Meng; Aftab A Ansari; Jeffrey D Butler; Ross L Coppel; M Eric Gershwin; Kathryn G Guggenheim; Thomas P Kenny; Mark J Kurth; Kit S Lam; Patrick S C Leung
Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.
Journal of autoimmunity 2011;37(3):209-16.
2011: Kai Xiao; Gabriel Fung; Joyce S Lee; Yuanpei Li; Juntao Luo; Kit S Lam
PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma.
Journal of controlled release : official journal of the Controlled Release Society 2011;155(2):272-81.
2011: Olulanu H Aina; Matthew Harrison; Kit S Lam; Yoshiko Maeda; Naomi J Walker; Allison L Zwingenberger; Michael S Kent
Canine malignant melanoma alpha-3 integrin binding peptides.
Veterinary immunology and immunopathology 2011;143(1-2):11-9.
2011: Yuanpei Li; Juntao Luo; Kai Xiao; Wenwu Xiao; Tiffany A Dong; Abby M Gonik; Jason Kato; Joyce S Lee; Kit S Lam
Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery.
Biomaterials 2011;32(27):6633-45.
2011: Nianhuan Yao; Chao-Yu Chen; Hsing-Jien Kung; Kiyomi Motonishi; Chun-Yi Wu; Kit S Lam
Novel flavonoids with antiproliferative activities against breast cancer cells.
Journal of medicinal chemistry 2011;54(13):4339-49.
2011: Pappanaicken Kumaresan; Yan Wang; Mary Saunders; Yoshiko Maeda; Ruiwu Liu; Xiaobing Wang; Kit S Lam
Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods.
ACS combinatorial science 2011;13(3):259-64.
2011: Kai Xiao; Yuanpei Li; Juntao Luo; Joyce S Lee; Wenwu Xiao; Abby M Gonik; Rinki G Agarwal; Kit S Lam
The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles.
Biomaterials 2011;32(13):3435-46.
2011: Yuzhe Ding; Lingfei Hong; Baoqing Nie; Kit S Lam; Tingrui Pan
Capillary-driven automatic packaging.
Lab on a chip 2011;11(8):1464-9.
2011: Pei-Ching Chang; Latricia D Fitzgerald; Datsun A Hsia; Yoshihiro Izumiya; Chun-Yi Wu; Wen-Ping Hsieh; Su-Fang Lin; Mel Campbell; Kit S Lam; Paul A Luciw; Clifford G Tepper; Hsing-Jien Kung
Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.
Journal of virology 2011;85(7):3283-93.
2011: Jie Li; Ruiwu Liu; Kit S Lam; Lee-Way Jin; Yong Duan
Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core.
Biophysical journal 2011;100(4):1076-82.
2011: Lifang Shi; Nai-Ning Yin; Christopher J Fleming; Kit S Lam; Juntao Luo; Shawn L Riechers; Gang-Yu Liu
High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy.
Journal of drug delivery 2011;2011():254095.
2010: Lorenzo Berti; Temesgen Woldeyesus; Yuanpei Li; Kit S Lam
Maximization of loading and stability of ssDNA:iron oxide nanoparticle complexes formed through electrostatic interaction.
Langmuir : the ACS journal of surfaces and colloids 2010;26(23):18293-9.
2010: Nianhuan Yao; Gabriel Fung; Hamed Malekan; Long Ye; Mark J Kurth; Kit S Lam
Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation.
Carbohydrate research 2010;345(15):2277-81.
2010: Wenwu Xiao; Yan Wang; Edmond Y Lau; Juntao Luo; Nianhuan Yao; Changying Shi; Leah Meza; Harry Tseng; Yoshiko Maeda; Pappanaicken Kumaresan; Ruiwu Liu; Felice C Lightstone; Yoshikazu Takada; Kit S Lam
The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle.
Molecular cancer therapeutics 2010;9(10):2714-23.
2010: Bei Xiang; Gang Sun; Kit S Lam; Kai Xiao
Novel poly(ethylene-co-acrylic acid) nanofibrous biomaterials for peptide synthesis and biomedical applications.
Journal of biomedical materials research. Part A 2010;95(1):245-55.
2010: Hyun-Seok Hong; Izumi Maezawa; Madhu S Budamagunta; Sandeep Rana; Aibin Shi; Robert Vassar; Ruiwu Liu; Kit S Lam; R Holland Cheng; Duy H Hua; John C Voss; Lee-Way Jin
Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents.
Neurobiology of aging 2010;31(10):1690-9.
2010: Jared B Townsend; Farzana Shaheen; Ruiwu Liu; Kit S Lam
Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries.
Journal of combinatorial chemistry 2010;12(5):700-12.
2010: Juntao Luo; Kai Xiao; Yuanpei Li; Joyce S Lee; Lifang Shi; Yih-Horng Tan; Li Xing; R Holland Cheng; Gang-Yu Liu; Kit S Lam
Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.
Bioconjugate chemistry 2010;21(7):1216-24.
2010: Richard D Carpenter; Arutselvan Natarajan; Edmond Y Lau; Mirela Andrei; Danielle M Solano; Felice C Lightstone; Sally J DeNardo; Kit S Lam; Mark J Kurth
Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas.
Cancer research 2010;70(13):5448-56.
2010: Yuanpei Li; Kai Xiao; Juntao Luo; Joyce Lee; Shirong Pan; Kit S Lam
A novel size-tunable nanocarrier system for targeted anticancer drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(3):314-23.
2010: Jared Townsend; Andrew Do; Alan Lehman; Seth Dixon; Babak Sanii; Kit S Lam
3-nitro-tyrosine as an internal quencher of autofluorescence enhances the compatibility of fluorescence based screening of OBOC combinatorial libraries.
Combinatorial chemistry & high throughput screening 2010;13(5):422-9.
2010: Florin Despa; J T Luo; J Li; Y Duan; Kit S Lam
Cholic acid micelles--controlling the size of the aqueous cavity by PEGylation.
Physical chemistry chemical physics : PCCP 2010;12(7):1589-94.
2010: Pei-Ching Chang; Yoshihiro Izumiya; Chun-Yi Wu; Latricia D Fitzgerald; Mel Campbell; Thomas J Ellison; Kit S Lam; Paul A Luciw; Hsing-Jien Kung
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific.
The Journal of biological chemistry 2010;285(8):5266-73.
2010: Emanual Maverakis; Juscilene S Menezes; Akio Ametani; Mei Han; David B Stevens; Yong He; Yan Wang; Yoko Ono; Yoshinori Miyamura; Kit S Lam; E Sally Ward; Eli E Sercarz
Molecular mimics can induce a nonautoaggressive repertoire that preempts induction of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2550-5.
2010: Zhaoju Wu; Joy C Yang; Pei-Ching Chang; Nien-Tsu Chen; Cheng-Ying Chu; Sonal J Desai; Christopher P Evans; Kit S Lam; Su Hao Lo; Ai-Hong Ma; Ling-Yu Wang; Hsing-Jien Kung
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.
Genes & cancer 2010;1(1):40-9.
2010: Yiyan Fei; James P Landry; Yungshin Sun; Xiangdong Zhu; Xiaobing Wang; Juntao Luo; Chun-Yi Wu; Kit S Lam
Screening small-molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope.
Journal of biomedical optics 2010;15(1):016018.
2009: Nianhuan Yao; Wenwu Xiao; Leah Meza; Harry Tseng; Mathida Chuck; Kit S Lam
Structure-activity relationship studies of targeting ligands against breast cancer cells.
Journal of medicinal chemistry 2009;52(21):6744-51.
2009: Kai Xiao; Juntao Luo; Wiley L Fowler; Yuanpei Li; Joyce S Lee; Li Xing; R Holland Cheng; Li Wang; Kit S Lam
A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer.
Biomaterials 2009;30(30):6006-16.
2009: Jun Saegusa; Satoshi Yamaji; Katsuaki Ieguchi; Chun-Yi Wu; Kit S Lam; Fu-Tong Liu; Yoko K Takada; Yoshikazu Takada
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
The Journal of biological chemistry 2009;284(36):24106-14.
2009: Rajesh R Nair; Michael F Emmons; Anne E Cress; Raul F Argilagos; Kit S Lam; William T Kerr; Hong-Gang Wang; William S Dalton; Lori A Hazlehurst
HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells.
Molecular cancer therapeutics 2009;8(8):2441-51.
2009: Y S Sun; James P Landry; Y Y Fei; Xiangdong Zhu; J T Luo; X B Wang; Kit S Lam
Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support.
Analytical chemistry 2009;81(13):5373-80.
2009: Sally J Denardo; Ruiwu Liu; Huguette Albrecht; Arutselvan Natarajan; Julie L Sutcliffe; Carolyn Anderson; Li Peng; Riccardo Ferdani; Simon R Cherry; Kit S Lam
111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(4):625-34.
2009: Tae Hun Kim; Senthil K Venugopal; Ming Zhu; Si-Si Wang; Derick H Lau; Kit S Lam; Dahn L Clemens; Mark A Zern
A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells.
Biochemical and biophysical research communications 2009;379(4):876-81.
2009: Nicholas J Kenyon; Ruiwu Liu; Erin M O'Roark; Wenzhe Huang; Li Peng; Kit S Lam
An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice.
European journal of pharmacology 2009;603(1-3):138-46.
2009: Richard D Carpenter; Mirela Andrei; Olulanu H Aina; Edmond Y Lau; Felice C Lightstone; Ruiwu Liu; Kit S Lam; Mark J Kurth
Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin.
Journal of medicinal chemistry 2009;52(1):14-9.
2009: Nianhuan Yao; Wenwu Xiao; Xiaobing Wang; Jan Marik; See-Hyoung Park; Yoshikazu Takada; Kit S Lam
Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.
Journal of medicinal chemistry 2009;52(1):126-33.
2009: Ming Zhu; Hyounggee Baek; Ruiwu Liu; Aimin Song; Kit S Lam; Derick H Lau
LAS0811: from combinatorial chemistry to activation of antioxidant response element.
Journal of biomedicine & biotechnology 2009;2009():420194.
2009: Joseph C Kappel; Yi C Fan; Kit S Lam
Application of the "libraries from libraries" concept to "one-bead one-compound" combinatorial chemistry.
Advances in experimental medicine and biology 2009;611():21-2.
2009: Juntao Luo; Ekama Onofiok; Changying Shi; Ruiwu Liu; Kit S Lam
A novel hydrogel functionalized with specific peptidomimetic ligands for 2-D and 3-D cell culture.
Advances in experimental medicine and biology 2009;611():19-20.
2009: Pappanaicken Kumaresan; Juntao Luo; Kit S Lam
On-demand cleavable linkers for radioimmunotherapy.
Methods in molecular biology (Clifton, N.J.) 2009;539():191-211.
2009: Hyoung Gee Baek; Ruiwu Liu; Kit S Lam
Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries.
Journal of combinatorial chemistry 2009;11(1):91-102.
2009: Wenwu Xiao; Nianhuan Yao; Li Peng; Ruiwu Liu; Kit S Lam
Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin.
European journal of nuclear medicine and molecular imaging 2009;36(1):94-103.
2008: Y S Sun; James P Landry; Y Y Fei; Xiangdong Zhu; J T Luo; X B Wang; Kit S Lam
Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions.
Langmuir : the ACS journal of surfaces and colloids 2008;24(23):13399-405.
2008: See-Hyoung Park; Xiaobing Wang; Ruiwu Liu; Kit S Lam; Robert H Weiss
High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers.
Cancer biology & therapy 2008;7(12):2015-22.
2008: Jun Saegusa; Nobuaki Akakura; Chun-Yi Wu; Case Hoogland; Zi Ma; Kit S Lam; Fu-Tong Liu; Yoko K Takada; Yoshikazu Takada
Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
The Journal of biological chemistry 2008;283(38):26107-15.
2008: Arutselvan Natarajan; Pappanaicken Kumaresan; Sally J DeNardo; Gerald L DeNardo; Gary R Mirick; Kit S Lam
Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy.
Bioorganic & medicinal chemistry letters 2008;18(17):4802-5.
2008: Bensheng Li; Hyun Joo An; Crystal Kirmiz; Carlito B Lebrilla; Kit S Lam; Suzanne Miyamoto
Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation changes in individual proteins.
Journal of proteome research 2008;7(9):3776-88.
2008: Kanji Wakabayashi; Zhe-Xiong Lian; Patrick S C Leung; Yuki Moritoki; Koichi tsuneyama; Mark J Kurth; Kit S Lam; Katsunori Yoshida; Guo-Xiang Yang; Toshifumi Hibi; Aftab A Ansari; William M Ridgway; Ross Coppel; Ian R Mackay; M Eric Gershwin
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.
Hepatology (Baltimore, Md.) 2008;48(2):531-40.
2008: Juntao Luo; Hongyong Zhang; Wenwu Xiao; Pappanaicken Kumaresan; Changying Shi; Chong-Xian Pan; Olulanu H Aina; Kit S Lam
Rainbow beads: a color coding method to facilitate high-throughput screening and optimization of one-bead one-compound combinatorial libraries.
Journal of combinatorial chemistry 2008;10(4):599-604.
2008: Seiji Mori; Chun-Yi Wu; Satoshi Yamaji; Jun Saegusa; Biao Shi; Zi Ma; Yasuko Kuwabara; Kit S Lam; R Rivkah Isseroff; Yoko K Takada; Yoshikazu Takada
Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
The Journal of biological chemistry 2008;283(26):18066-75.
2008: Pappanaicken Kumaresan; Juntao Luo; Aimin Song; Jan Marik; Kit S Lam
Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates.
Bioconjugate chemistry 2008;19(6):1313-8.
2008: Gary S Leiserowitz; Carlito B Lebrilla; S Miyamoto; Hyun Joo An; H Duong; C Kirmiz; B Li; H Liu; Kit S Lam
Glycomics analysis of serum: a potential new biomarker for ovarian cancer?
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008;18(3):470-5.
2008: Joseph C Kappel; Yi C Fan; Kit S Lam
Global transformation of OBOC combinatorial peptide libraries into OBOC polyamine and small molecule libraries.
Journal of combinatorial chemistry 2008;10(2):333-42.
2008: Suzanne Miyamoto; Ruiwu Liu; Susan Hung; Xiaobing Wang; Kit S Lam
Screening of a one bead-one compound combinatorial library for beta-actin identifies molecules active toward Ramos B-lymphoma cells.
Analytical biochemistry 2008;374(1):112-20.
2008: Li Peng; Ruiwu Liu; Mirela Andrei; Wenwu Xiao; Kit S Lam
In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin.
Molecular cancer therapeutics 2008;7(2):432-7.
2008: Maria Lorna A de Leoz; Hyun Joo An; Scott Kronewitter; Jaehan Kim; Sean Beecroft; Ruth Vinall; Suzanne Miyamoto; Ralph W deVere White; Kit S Lam; Carlito B Lebrilla
Glycomic approach for potential biomarkers on prostate cancer: profiling of N-linked glycans in human sera and pRNS cell lines.
Disease markers 2008;25(4-5):243-58.
2008: Richard D Carpenter; James C Fettinger; Kit S Lam; Mark J Kurth
Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions.
Angewandte Chemie (International ed. in English) 2008;47(34):6407-10.
2008: Nianhuan Yao; Chun-Yi Wu; Wenwu Xiao; Kit S Lam
Discovery of high-affinity peptide ligands for vancomycin.
Biopolymers 2008;90(3):421-32.
2008: Y Y Fei; James P Landry; Y S Sun; Xiangdong Zhu; J T Luo; X B Wang; Kit S Lam
A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays.
The Review of scientific instruments 2008;79(1):013708.
2008: Izumi Maezawa; Hyun-Seok Hong; Ruiwu Liu; Chun-Yi Wu; R Holland Cheng; Mei-Ping Kung; Hank F Kung; Kit S Lam; Salvatore Oddo; Frank M LaFerla; Lee-Way Jin
Congo red and thioflavin-T analogs detect Abeta oligomers.
Journal of neurochemistry 2008;104(2):457-68.
2007: Richard D Carpenter; Mirela Andrei; Edmond Y Lau; Felice C Lightstone; Ruiwu Liu; Kit S Lam; Mark J Kurth
Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin.
Journal of medicinal chemistry 2007;50(23):5863-7.
2007: Ning Wang; Kevin Lin; Zhongxian Lu; Kit S Lam; R Newton; Xiaoman Xu; Zhengquan Yu; Gordon N Gill; Bogi Andersen
The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells.
Oncogene 2007;26(44):6431-41.
2007: Olulanu H Aina; Ruiwu Liu; Julie L Sutcliffe; Jan Marik; Chong-Xian Pan; Kit S Lam
From combinatorial chemistry to cancer-targeting peptides.
Molecular pharmaceutics 2007;4(5):631-51.
2007: Patrick S C Leung; Ogyi Park; Koichi tsuneyama; Mark J Kurth; Kit S Lam; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2651-7.
2007: Christine L Hartmann Siantar; Gerald L DeNardo; Kit S Lam; Aina Yuan; Thomas P Daly; Sally J DeNardo
Selecting an intervention time for intravascular enzymatic cleavage of peptide linkers to clear radioisotope from normal tissues.
Cancer biotherapy & radiopharmaceuticals 2007;22(4):556-63.
2007: Nianhuan Yao; Aiming Song; Xiaobing Wang; Seth Dixon; Kit S Lam
Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries.
Journal of combinatorial chemistry 2007;9(4):668-76.
2007: Xiangdong Zhu; James P Landry; Yung-Shin Sun; Jeffrey P Gregg; Kit S Lam; Xiaowen Guo
Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format.
Applied optics 2007;46(10):1890-5.
2007: Yoshihiro Izumiya; Chie Izumiya; Albert Van Geelen; Don-Hong Wang; Kit S Lam; Paul A Luciw; Hsing-Jien Kung
Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP.
Journal of virology 2007;81(3):1072-82.
2007: Hyun-Seok Hong; Izumi Maezawa; Nianhuan Yao; Bailing Xu; Ruben Diaz-Avalos; Sandeep Rana; Duy H Hua; R Holland Cheng; Kit S Lam; Lee-Way Jin
Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.
Brain research 2007;1130(1):223-34.
2007: Richard D Carpenter; Kit S Lam; Mark J Kurth
Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones.
The Journal of organic chemistry 2007;72(1):284-7.
2007: Pappanaicken Kumaresan; Arutselvan Natarajan; Aimin Song; Xiaobing Wang; Ruiwu Liu; Gerald DeNardo; Sally DeNardo; Kit S Lam
Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries.
Bioconjugate chemistry 2007;18(1):175-82.
2007: Seth M Dixon; Kristin A Milinkevich; Jeffrey Fujii; Ruiwu Liu; Nianhuan Yao; Kit S Lam; Mark J Kurth
A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis.
Journal of combinatorial chemistry 2007;9(1):143-57.
2007: Crystal Kirmiz; Bensheng Li; Hyun Joo An; Brian H Clowers; Helen K Chew; Kit S Lam; Anthony Ferrige; Robert Alecio; Alexander D Borowsky; Shola Sulaimon; Carlito B Lebrilla; Suzanne Miyamoto
A serum glycomics approach to breast cancer biomarkers.
Molecular & cellular proteomics : MCP 2007;6(1):43-55.
2006: Seth Dixon; Kristin T Ziebart; Ze He; Melissa R Jeddeloh; Choong Leol Yoo; Xiaobing Wang; Alan Lehman; Kit S Lam; Michael D Toney; Mark J Kurth
Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design.
Journal of medicinal chemistry 2006;49(25):7413-26.
2006: Thomas C Sroka; Jan Marik; Michael E Pennington; Kit S Lam; Anne E Cress
The minimum element of a synthetic peptide required to block prostate tumor cell migration.
Cancer biology & therapy 2006;5(11):1556-62.
2006: Richard D Carpenter; Patrick B Deberdt; Kit S Lam; Mark J Kurth
Carbodiimide-based benzimidazole library method.
Journal of combinatorial chemistry 2006;8(6):907-14.
2006: Roman Rieger; Patrick S C Leung; Melissa R Jeddeloh; Mark J Kurth; Michael H Nantz; Kit S Lam; Daniel Barsky; Aftab A Ansari; Ross Coppel; Ian R Mackay; M Eric Gershwin
Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis.
Journal of autoimmunity 2006;27(1):7-16.
2006: Alan Lehman; Sepideh Gholami; Min Hahn; Kit S Lam
Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures.
Journal of combinatorial chemistry 2006;8(4):562-70.
2006: Hyun Joo An; Suzanne Miyamoto; Katherine S Lancaster; Crystal Kirmiz; Bensheng Li; Kit S Lam; Gary S Leiserowitz; Carlito B Lebrilla
Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer.
Journal of proteome research 2006;5(7):1626-35.
2006: Li Peng; Ruiwu Liu; Jan Marik; Xiaobing Wang; Yoshikazu Takada; Kit S Lam
Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.
Nature chemical biology 2006;2(7):381-9.
2006: Derick H Lau; Linlang Guo; Ruiwu Liu; Jan Marik; Kit S Lam
Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;52(3):291-7.
2006: Zhongxian Lu; Kit S Lam; Ning Wang; Xiaoman Xu; M Cortes; Bogi Andersen
LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.
Oncogene 2006;25(20):2920-30.
2006: Pappanaicken Kumaresan; Kit S Lam
Screening chemical microarrays: methods and applications.
Molecular bioSystems 2006;2(5):259-70.
2006: Seth M Dixon; Pu Li; Ruiwu Liu; Herman Wolosker; Kit S Lam; Mark J Kurth; Michael D Toney
Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries.
Journal of medicinal chemistry 2006;49(8):2388-97.
2006: Ruiwu Liu; Li Peng; Huijun Han; Kit S Lam
Structure-activity relationship studies of a series of peptidomimetic ligands for alpha(4) beta(1) integrin on Jurkat T-leukemia cells.
Biopolymers 2006;84(6):595-604.
2005: Olulanu H Aina; Jan Marik; Regina Gandour-Edwards; Kit S Lam
Near-infrared optical imaging of ovarian cancer xenografts with novel alpha 3-integrin binding peptide "OA02".
Molecular imaging 2005;4(4):439-47.
2005: Seth Dixon; Lori I Robins; Robert A Elling; Ruiwu Liu; Kit S Lam; David K Wilson; Mark J Kurth
Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy.
Bioorganic & medicinal chemistry letters 2005;15(11):2938-42.
2005: Nian-Huan Yao; Gang Liu; Wen-Yi He; Changqun Niu; James R Carlson; Kit S Lam
Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives.
Bioorganic & medicinal chemistry letters 2005;15(9):2325-9.
2005: Olulanu H Aina; Jan Marik; Ruiwu Liu; Derick H Lau; Kit S Lam
Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries.
Molecular cancer therapeutics 2005;4(5):806-13.
2005: Laiqiang Ying; Ruiwu Liu; Jinhua Zhang; Kit S Lam; Carlito B Lebrilla; Jacquelyn Gervay-Hague
A topologically segregated one-bead-one-compound combinatorial glycopeptide library for identification of lectin ligands.
Journal of combinatorial chemistry 2005;7(3):372-84.
2005: Katsushi Amano; Patrick S C Leung; Roman Rieger; Chao Quan; Xiaobing Wang; Jan Marik; Yat Fan Suen; Mark J Kurth; Michael H Nantz; Aftab A Ansari; Kit S Lam; Mikio Zeniya; Eiji Matsuura; Ross Coppel; M Eric Gershwin
Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5874-83.
2005: Robert J Gillies; John M Hoffman; Kit S Lam; Anne Menkens; David R Piwnica-Worms; Daniel C Sullivan; Ralph Weissleder
Meeting report: high-throughput technologies for in vivo imaging agents.
Molecular imaging 2005;4(2):98-103.
2005: Xiaobing Wang; Li Peng; Ruiwu Liu; Sukhjinder S Gill; Kit S Lam
Partial alloc-deprotection approach for ladder synthesis of "one-bead one-compound" combinatorial libraries.
Journal of combinatorial chemistry 2005;7(2):197-209.
2005: Jan Marik; Kit S Lam
Peptide and small-molecule microarrays.
Methods in molecular biology (Clifton, N.J.) 2005;310():217-26.
2005: Xiaobing Wang; L Peng; Ruiwu Liu; B Xu; Kit S Lam
Applications of topologically segregated bilayer beads in 'one-bead one-compound' combinatorial libraries.
The journal of peptide research : official journal of the American Peptide Society 2005;65(1):130-8.
2005: Nian-Huan Yao; Wen-Yi He; Kit S Lam; Gang Liu
Conformational studies of resin-bound vancomycin and the complex of vancomycin and Ac2-L-Lys-D-Ala-D-Ala.
Journal of combinatorial chemistry 2005;7(1):123-9.
2004: Sung Hee Hwang; Alan Lehman; Xin Cong; Marilyn M Olmstead; Kit S Lam; Carlito B Lebrilla; Mark J Kurth
OBOC small-molecule combinatorial library encoded by halogenated mass-tags.
Organic letters 2004;6(21):3829-32.
2004: Masahito Mikawa; Henry Wang; Linlang Guo; Ruiwu Liu; Jan Marik; Yoshikazu Takada; Kit S Lam; Derick H Lau
Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells.
Molecular cancer therapeutics 2004;3(10):1329-34.
2004: Cynthia L Martel; Yueju Li; Laurel Beckett; Helen K Chew; Scott Christensen; Angela Davies; Kit S Lam; Derick H Lau; Frederick J Meyers; Robert T O'Donnell; Carol M Richman; Sidney Scudder; Michael Tanaka; Joseph M Tuscano; Jeanna Welborn; Ted Wun; David R Gandara; Primo Lara
An evaluation of barriers to accrual in the era of legislation requiring insurance coverage of cancer clinical trial costs in California.
Cancer journal (Sudbury, Mass.) 2004;10(5):294-300.
2004: Aimin Song; Jinhua Zhang; Carlito B Lebrilla; Kit S Lam
Solid-phase synthesis and spectral properties of 2-alkylthio-6H-pyrano[2,3-f]benzimidazole-6-ones: a combinatorial approach for 2-alkylthioimidazocoumarins.
Journal of combinatorial chemistry 2004;6(4):604-10.
2004: Katsushi Amano; Patrick S C Leung; Qingchai Xu; Jan Marik; Chao Quan; Mark J Kurth; Michael H Nantz; Aftab A Ansari; Kit S Lam; Mikio Zeniya; Ross Coppel; M Eric Gershwin
Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6444-52.
2004: Xiaobing Wang; Jinhua Zhang; Aimin Song; Carlito B Lebrilla; Kit S Lam
Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags.
Journal of the American Chemical Society 2004;126(18):5740-9.
2004: Nian-Huan Yao; Wen-Yi He; Kit S Lam; Gang Liu
Solid-phase synthesis of O-glycosylated Nalpha-Fmoc amino acids and analysis by high-resolution magic angle spinning NMR.
Journal of combinatorial chemistry 2004;6(2):214-9.
2004: Ruiwu Liu; Ching-Yi Hsieh; Kit S Lam
New approaches in identifying drugs to inactivate oncogene products.
Seminars in cancer biology 2004;14(1):13-21.
2004: Aimin Song; Xiaobing Wang; Jinhua Zhang; Jan Marík; Carlito B Lebrilla; Kit S Lam
Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase.
Bioorganic & medicinal chemistry letters 2004;14(1):161-5.
2004: Qingchai Xu; Suzanne Miyamoto; Kit S Lam
A novel approach to chemical microarray using ketone-modified macromolecular scaffolds: application in micro cell-adhesion assay.
Molecular diversity 2004;8(3):301-10.
2004: Aimin Song; Jinhua Zhang; Kit S Lam
Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combinatorial synthesis of coumarins.
Journal of combinatorial chemistry 2004;6(1):112-20.
2003: J R Kamath; Ruiwu Liu; A M Enstrom; Q Lou; Kit S Lam
Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach.
The journal of peptide research : official journal of the American Peptide Society 2003;62(6):260-8.
2003: Gerald L DeNardo; Sally J DeNardo; James J Peterson; Laird A Miers; Kit S Lam; Christine Hartmann Siantar; Kathleen R Lamborn
Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 2):3865S-72S.
2003: Sally J DeNardo; Zhengsheng Yao; Kit S Lam; Aimin Song; Patricia A Burke; Gary R Mirick; Kathleen R Lamborn; Robert T O'Donnell; Gerald L DeNardo
Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 2):3854S-64S.
2003: Kit S Lam; Ruiwu Liu; Suzanne Miyamoto; Alan L Lehman; Joseph M Tuscano
Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research.
Accounts of chemical research 2003;36(6):370-7.
2003: Aimin Song; Jinhua Zhang; Carlito B Lebrilla; Kit S Lam
A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries.
Journal of the American Chemical Society 2003;125(20):6180-8.
2003: Patrick S C Leung; Chao Quan; Ogyi Park; Judith A van de Water; Mark J Kurth; Michael H Nantz; Aftab A Ansari; Ross Coppel; Kit S Lam; M Eric Gershwin
Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5326-32.
2003: Andreas H Franz; Ruiwu Liu; Aimin Song; Kit S Lam; Carlito B Lebrilla
High-throughput one-bead-one-compound approach to peptide-encoded combinatorial libraries: MALDI-MS analysis of single TentaGel beads.
Journal of combinatorial chemistry 2003;5(2):125-37.
2003: Kit S Lam; Alan L Lehman; Aimin Song; Ninh Doan; Amanda M Enstrom; Joseph Maxwell; Ruiwu Liu
Synthesis and screening of "one-bead one-compound" combinatorial peptide libraries.
Methods in enzymology 2003;369():298-322.
2003: Ruiwu Liu; Jan Marik; Kit S Lam
Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinatorial libraries.
Methods in enzymology 2003;369():271-87.
2003: Ruiwu Liu; Amanda M Enstrom; Kit S Lam
Combinatorial peptide library methods for immunobiology research.
Experimental hematology 2003;31(1):11-30.
2002: Wei-Chieh Cheng; Yannan Liu; Melissa Wong; Marilyn M Olmstead; Kit S Lam; Mark J Kurth
Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives.
The Journal of organic chemistry 2002;67(16):5673-7.
2002: Ruiwu Liu; Jan Marik; Kit S Lam
A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries.
Journal of the American Chemical Society 2002;124(26):7678-80.
2002: Kit S Lam; Manat Renil
From combinatorial chemistry to chemical microarray.
Current opinion in chemical biology 2002;6(3):353-8.
2002: James S Nowick; Kit S Lam; Tatiana Khasanova; William E Kemnitzer; Santanu Maitra; Hao T Mee; Ruiwu Liu
An unnatural amino acid that induces beta-sheet folding and interaction in peptides.
Journal of the American Chemical Society 2002;124(18):4972-3.
2002: Jinzi J Wu; Daniel E H Afar; Hoang Phan; Owen N Witte; Kit S Lam
Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase.
Combinatorial chemistry & high throughput screening 2002;5(1):83-91.
2002: Scott R Nagy; Gang Liu; Kit S Lam; Michael S Denison
Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay.
Biochemistry 2002;41(3):861-8.
2002: Olulanu H Aina; Thomas C Sroka; Man-Ling Chen; Kit S Lam
Therapeutic cancer targeting peptides.
Biopolymers 2002;66(3):184-99.
2001: S Alice Long; Chao Quan; Judith A van de Water; Michael H Nantz; Mark J Kurth; Daniel Barsky; M E Colvin; Kit S Lam; Ross Coppel; Aftab A Ansari; M Eric Gershwin
Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2956-63.
2001: Ruiwu Liu; Kit S Lam
Automatic Edman microsequencing of peptides containing multiple unnatural amino acids.
Analytical biochemistry 2001;295(1):9-16.
2001: J R Falsey; M Renil; S Park; S Li; Kit S Lam
Peptide and small molecule microarray for high throughput cell adhesion and functional assays.
Bioconjugate chemistry 2001;12(3):346-53.
2001: I B DeRoock; Michael E Pennington; Thomas C Sroka; Kit S Lam; George Bowden; Elisabeth L Bair; Anne E Cress
Synthetic peptides inhibit adhesion of human tumor cells to extracellular matrix proteins.
Cancer research 2001;61(8):3308-13.
2001: M Miyashita; J M Presley; Bruce Buchholz; Kit S Lam; Y M Lee; John S Vogel; Bruce D Hammock
Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4403-8.
2001: C Migliaccio; Judith A van de Water; Aftab A Ansari; Marshall M Kaplan; Ross Coppel; Kit S Lam; R K Thompson; F Stevenson; M Eric Gershwin
Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.
Hepatology (Baltimore, Md.) 2001;33(4):792-801.
2001: Primo Lara; R Higdon; N Lim; K Kwan; M Tanaka; Derick H Lau; Ted Wun; Jeanna Welborn; Frederick J Meyers; S Christensen; Robert T O'Donnell; Carol M Richman; Sidney Scudder; Joseph M Tuscano; David R Gandara; Kit S Lam
Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(6):1728-33.
2000: F A Al-Obeidi; Kit S Lam
Development of inhibitors for protein tyrosine kinases.
Oncogene 2000;19(49):5690-701.
2000: G Liu; Y Fan; J R Carlson; Z G Zhao; Kit S Lam
Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library.
Journal of combinatorial chemistry 2000;2(5):467-74.
1999: Z G Zhao; J S Im; Kit S Lam; Douglas F. Lake
Site-specific modification of a single-chain antibody using a novel glyoxylyl-based labeling reagent.
Bioconjugate chemistry 1999;10(3):424-30.
1998: Margaret H Smith; A A Nuara; J G Egen; D B Sirjani; Kit S Lam; W J Grimes
Baculoviral expressed HLA class I heavy chains used to screen a synthetic peptide library for allele-specific peptide binding motifs.
Molecular immunology 1998;35(16):1033-43.
1998: J J Wu; H Phan; Kit S Lam
Comparison of the intrinsic kinase activity and substrate specificity of c-Abl and Bcr-Abl.
Bioorganic & medicinal chemistry letters 1998;8(17):2279-84.
1998: Josue Alfaro-Lopez; W Yuan; B C Phan; J Kamath; Q Lou; Kit S Lam; Victor J Hruby
Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design.
Journal of medicinal chemistry 1998;41(13):2252-60.
1998: Thomas P Miller; E M Chase; Robert T Dorr; William S Dalton; Kit S Lam; Sydney E Salmon
A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease.
Anti-cancer drugs 1998;9(2):135-40.
1998: F A al-Obeidi; J J Wu; Kit S Lam
Protein tyrosine kinases: structure, substrate specificity, and drug discovery.
Biopolymers 1998;47(3):197-223.
1998: Kit S Lam; Thomas C Sroka; M L Chen; Y Zhao; Q Lou; J Wu; Z G Zhao
Application of "one-bead one-compound" combinatorial library methods in signal transduction research.
Life sciences 1998;62(17-18):1577-83.
1998: Kit S Lam
Determination of peptide substrate motifs for protein kinases using a "one-bead one-compound" combinatorial library approach.
Methods in molecular biology (Clifton, N.J.) 1998;87():83-6.
1998: Kit S Lam
Enzyme-linked colorimetric screening of a one-bead one-compound combinatorial library.
Methods in molecular biology (Clifton, N.J.) 1998;87():7-12.
1998: Kit S Lam; Michal Lebl
Synthesis of a one-bead one-compound combinatorial peptide library.
Methods in molecular biology (Clifton, N.J.) 1998;87():1-6.
1997: Kit S Lam; Z G Zhao
Targeted therapy for lymphoma with peptides.
Hematology/oncology clinics of North America 1997;11(5):1007-19.
1997: Q Lou; M E Leftwich; R T McKay; Sydney E Salmon; L Rychetsky; Kit S Lam
Potent pseudosubstrate-based peptide inhibitors for p60(c-src) protein tyrosine kinase.
Cancer research 1997;57(10):1877-81.
1997: Kit S Lam
Application of combinatorial library methods in cancer research and drug discovery.
Anti-cancer drug design 1997;12(3):145-67.
1996: Sydney E Salmon; R H Liu-Stevens; Y Zhao; Michal Lebl; V Krchñák; K Wertman; N Sepetov; Kit S Lam
High-volume cellular screening for anticancer agents with combinatorial chemical libraries: a new methodology.
Molecular diversity 1996;2(1-2):57-63.
1996: Victor J Hruby; MD Shenderovich; Kit S Lam; Michal Lebl
Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry.
Molecular diversity 1996;2(1-2):46-56.
1996: Michael E Pennington; Kit S Lam; Anne E Cress
The use of a combinatorial library method to isolate human tumor cell adhesion peptides.
Molecular diversity 1996;2(1-2):19-28.
1996: J Vágner; George Barany; Kit S Lam; V Krchnák; N F Sepetov; J A Ostrem; P Strop; Michal Lebl
Enzyme-mediated spatial segregation on individual polymeric support beads: application to generation and screening of encoded combinatorial libraries.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8194-9.
1996: V Krchnák; A S Weichsel; O Issakova; Kit S Lam; Michal Lebl
Bifunctional scaffolds as templates for synthetic combinatorial libraries.
Molecular diversity 1996;1(3):177-82.
1996: Q Lou; M E Leftwich; Kit S Lam
Identification of GIYWHHY as a novel peptide substrate for human p60c-src protein tyrosine kinase.
Bioorganic & medicinal chemistry 1996;4(5):677-82.
1996: Q Lou; J Wu; Kit S Lam
A protein kinase assay system for both acidic and basic peptides.
Analytical biochemistry 1996;235(1):107-9.
1996: C L Chen; P Strop; Michal Lebl; Kit S Lam
One bead-one compound combinatorial peptide library: different types of screening.
Methods in enzymology 1996;267():211-9.
1995: N F Sepetov; V Krchnák; M Stanková; S Wade; Kit S Lam; Michal Lebl
Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5426-30.
1995: Kit S Lam; J Wu; Q Lou
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases.
International journal of peptide and protein research 1995;45(6):587-92.
1995: Kit S Lam; S Wade; F Abdul-Latif; Michal Lebl
Application of a dual color detection scheme in the screening of a random combinatorial peptide library.
Journal of immunological methods 1995;180(2):219-23.
1995: Kit S Lam; Q Lou; Z G Zhao; J Smith; M L Chen; E Pleshko; S E Salmon
Idiotype specific peptides bind to the surface immunoglobulins of two murine B-cell lymphoma lines, inducing signal transduction.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity 1995;1(3):205-10.
1995: Michal Lebl; V Krchnák; N F Sepetov; B Seligmann; P Strop; S Felder; Kit S Lam
One-bead-one-structure combinatorial libraries.
Biopolymers 1995;37(3):177-98.
1994: J Wu; Q N Ma; Kit S Lam
Identifying substrate motifs of protein kinases by a random library approach.
Biochemistry 1994;33(49):14825-33.
1994: M H Smith; Kit S Lam; Evan M Hersh; Michal Lebl; W J Grimes
Peptide sequences binding to MHC class I proteins.
Molecular immunology 1994;31(18):1431-7.
1994: M Stanková; S Wade; Kit S Lam; Michal Lebl
Synthesis of combinatorial libraries with only one representation of each structure.
Peptide research 1994;7(6):292-8.
1994: Douglas F. Lake; Kit S Lam; L Peng; Evan M Hersh
Molecular cloning, expression and mutagenesis of an anti-insulin single chain Fv (scFv).
Molecular immunology 1994;31(11):845-56.
1994: S E Salmon; Kit S Lam; S Felder; H Yeoman; J Schlessinger; A Ullrich; V Krchnák; Michal Lebl
One bead, one chemical compound: use of the selectide process for anticancer drug discovery.
Acta oncologica (Stockholm, Sweden) 1994;33(2):127-31.
1993: Kit S Lam; Michal Lebl; V Krchnak; S Wade; F Abdul-Latif; R Ferguson; C Cuzzocrea; K Wertman
Discovery of D-amino-acid-containing ligands with selectide technology.
Gene 1993;137(1):13-6.
1993: S E Salmon; Kit S Lam; Michal Lebl; A Kandola; P S Khattri; S Wade; M Pátek; P Kocis; V Krchnák; David S Thorpe
Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11708-12.
1993: Kit S Lam
Treatment of B-cell lymphoma using peptides. A novel concept.
The Western journal of medicine 1993;158(5):475-9.
1993: V Nikolaiev; A Stierandová; V Krchnák; B Seligmann; Kit S Lam; S E Salmon; Michal Lebl
Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid-phase supports.
Peptide research 1993;6(3):161-70.
1993: Michal Lebl; M Pátek; P Kocis; V Krchnák; V J Hruby; S E Salmon; Kit S Lam
Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry.
International journal of peptide and protein research 1993;41(2):201-3.
1993: Victor J Hruby; Kit S Lam; Michal Lebl; W Kazmierski; Evan M Hersh; S E Salmon
Preparation of large peptide libraries with one peptide per bead and their use for the discovery of peptides that bind to acceptors.
NIDA research monograph 1993;134():75-83.
1992: Kit S Lam; D S Alberts; Yei-Mei Peng; F Brodar; B Matias; M Modiano; R Tuttle; V Sol Lucas; W Wargin
Phase I and pharmacokinetic study of 502U83 (an arylmethylaminopropanediol) in cancer patients.
Anti-cancer drugs 1992;3(3):219-24.
1991: Kit S Lam; S E Salmon; Evan M Hersh; V J Hruby; W M Kazmierski; Richard J Knapp
A new type of synthetic peptide library for identifying ligand-binding activity.
Nature 1991;354(6348):82-4.
1991: Anita S Chong; J K Pinkard; Kit S Lam; P Scuderi; Evan M Hersh; W J Grimes
Ability of cell-sized beads bearing tumor cell membrane proteins to stimulate LAK cells to secrete interferon-gamma and tumor necrosis factor-alpha.
Cellular immunology 1991;134(1):96-110.
1988: Kit S Lam; P Scuderi; S E Salmon
Analysis of the molecular organization of recombinant human tumor necrosis factor (rTNF) in solution using ethylene glycolbis(succinimidylsuccinate) as the cross-linking reagent.
Journal of biological response modifiers 1988;7(3):267-75.
1983: N N Teng; Kit S Lam; F Calvo Riera; H S Kaplan
Construction and testing of mouse--human heteromyelomas for human monoclonal antibody production.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7308-12.
1981: Kit S Lam; C B Kasper
Comparative studies on the endogenous phosphorylation of microsomal membrane derived from Morris hepatoma, eight-day-old rats, and host livers in the presence of micromolar levels of Mg2+ ion.
Cancer research 1981;41(3):860-3.
1980: Kit S Lam; C B Kasper
Sequence homology analysis of a heterogenous protein population by chemical and enzymic digestion using a two-dimensional sodium dodecyl sulfate-polyacrylamide gel system.
Analytical biochemistry 1980;108(2):220-6.
1980: Kit S Lam; C B Kasper
Chemical synthesis of [32P]pyrophosphate with high specific activity.
Analytical biochemistry 1980;108(2):279-81.
1980: Kit S Lam; C B Kasper
Pyrophosphate:protein phosphotransferase: a membrane-bound enzyme of endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):1927-31.
1980: Kit S Lam; C B Kasper
Selective endogenous phosphorylation of two liver microsomal polypeptides in the presence of micromolar levels of Mg2+ ion.
The Journal of biological chemistry 1980;255(1):259-66.
1979: Kit S Lam; C B Kasper
Electrophoretic analysis of three major nuclear envelope polypeptides. Topological relationship and sequence homology.
The Journal of biological chemistry 1979;254(22):11713-20.
1979: Kit S Lam; C B Kasper
Selective phosphorylation of a nuclear envelope polypeptide by an endogenous protein kinase.
Biochemistry 1979;18(2):307-11.