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Heather Lamb

Research Profile

Living Beings

Aspergillus nidulans

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Physiology

Gene Expression Regulation, Fungal

Procedures

X Ray Crystallography

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Publications

TOP 3
Charles E Nichols; K El Omari; P Thompson; Ian G Charles; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; David K Stammers
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.
Anna L Stamp; Ian G Charles; Kamel El Omari; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; Paul Owen; David K Stammers
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.
Anna L Stamp; Paul Owen; Kamel El Omari; Charles E Nichols; Michael Lockyer; Heather K Lamb; Ian G Charles; Alastair R Hawkins; David K Stammers
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

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All Publications

2013: Charles E Nichols; K El Omari; P Thompson; Ian G Charles; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; David K Stammers
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.
Protein science : a publication of the Protein Society 2013;22(5):628-40.
2011: Anna L Stamp; Ian G Charles; Kamel El Omari; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; Paul Owen; David K Stammers
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.
Proteins 2011;79(7):2352-7.
2010: Anna L Stamp; Paul Owen; Kamel El Omari; Charles E Nichols; Michael Lockyer; Heather K Lamb; Ian G Charles; Alastair R Hawkins; David K Stammers
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.
Protein science : a publication of the Protein Society 2010;19(10):1897-905.
2010: Xiao Zhao; Samantha L Hume; Christopher Johnson; Paul Thompson; Junyong Huang; Joe Gray; Heather K Lamb; Alastair R Hawkins
The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.
Protein science : a publication of the Protein Society 2010;19(7):1405-19.
2008: Masayo Kotaka; Christopher Johnson; Heather K Lamb; Alastair R Hawkins; Jingshan Ren; David K Stammers
Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.
Journal of molecular biology 2008;381(2):373-82.
2008: Heather K Lamb; David K Stammers; Alastair R Hawkins
Dinucleotide-sensing proteins: linking signaling networks and regulating transcription.
Science signaling 2008;1(33):pe38.
2007: Charles E Nichols; C Johnson; Heather K Lamb; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):922-8.
2007: Heather K Lamb; Paul Thompson; Catherine Elliott; Ian G Charles; Jamie Richards; Michael Lockyer; Nicholas Watkins; Charles Nichols; David K Stammers; Clive R Bagshaw; Alan Cooper; Alastair R Hawkins
Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.
Protein science : a publication of the Protein Society 2007;16(11):2391-402.
2007: Charles E Nichols; Heather K Lamb; Michael Lockyer; Ian G Charles; Susan Pyne; Alastair R Hawkins; David K Stammers
Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.
Proteins 2007;68(1):13-25.
2006: David A Chalton; Julie A Musson; Helen Flick-Smith; Nicola Walker; Alistair McGregor; Heather K Lamb; E Diane Williamson; Julie Miller; John Robinson; Jeremy H Lakey
Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation.
Infection and immunity 2006;74(12):6624-31.
2006: Charles E Nichols; C Johnson; Michael Lockyer; Ian G Charles; Heather K Lamb; Alastair R Hawkins; David K Stammers
Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog.
Proteins 2006;64(1):111-23.
2006: Heather K Lamb; Christopher Mee; Weiming XU; Lizhi Liu; Sylvie Blond; Alan Cooper; Ian G Charles; Alastair R Hawkins
The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.
The Journal of biological chemistry 2006;281(13):8796-805.
2005: Jingshan Ren; Masayo Kotaka; Michael Lockyer; Heather K Lamb; Alastair R Hawkins; David K Stammers
GTP cyclohydrolase II structure and mechanism.
The Journal of biological chemistry 2005;280(44):36912-9.
2004: Heather K Lamb; Jingshan Ren; Alison Park; Christopher Johnson; Kris Leslie; Simon Cocklin; Paul Thompson; Christopher Mee; Alan Cooper; David K Stammers; Alastair R Hawkins
Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.
Protein science : a publication of the Protein Society 2004;13(12):3127-38.
2004: Alison Park; Heather K Lamb; Charlie Nichols; Jonathan D Moore; Katherine A Brown; Alan Cooper; Ian G Charles; David K Stammers; Alastair R Hawkins
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.
Protein science : a publication of the Protein Society 2004;13(8):2108-19.
2003: Heather K Lamb; Kris Leslie; Anna L Dodds; Margaret Nutley; Alan Cooper; Christopher Johnson; Paul Thompson; David K Stammers; Alastair R Hawkins
The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
The Journal of biological chemistry 2003;278(34):32107-14.
2003: Charles E Nichols; Jingshan Ren; Heather K Lamb; Alastair R Hawkins; David K Stammers
Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.
Journal of molecular biology 2003;327(1):129-44.
2002: Alison Spiers; Heather K Lamb; Simon Cocklin; Kerry A Wheeler; Jo Budworth; Anna L Dodds; Mark J Pallen; Duncan J Maskell; Ian G Charles; Alastair R Hawkins
PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide.
The Journal of biological chemistry 2002;277(42):39443-9.
2002: Carys Watts; Shi Ming Si-Hoe; Heather K Lamb; Lisa J Levett; John R Coggins; Alastair R Hawkins
Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins.
Proteins 2002;48(2):161-8.
2001: David K Stammers; Jingshan Ren; Kris Leslie; Charles E Nichols; Heather K Lamb; Simon Cocklin; Anna L Dodds; Alastair R Hawkins
The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
The EMBO journal 2001;20(23):6619-26.
2000: Lisa J Levett; S M Si-Hoe; Stephen T Liddle; K Wheeler; D Smith; Heather K Lamb; G H Newton; John R Coggins; Alastair R Hawkins
Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein.
The Biochemical journal 2000;350 Pt 1():189-97.
1997: Heather K Lamb; Anna L Dodds; D R Swatman; E Cairns; Alastair R Hawkins
Deletion of the N-terminal region of the AREA protein is correlated with a derepressed phenotype with respect to nitrogen metabolite repression.
Journal of bacteriology 1997;179(21):6649-56.
1997: S S Awad; Heather K Lamb; J M Morgan; W Dunlop; James I Gillespie
Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.
The Biochemical journal 1997;322 ( Pt 3)():777-83.
1996: Heather K Lamb; G H Newton; L J Levett; E Cairns; C F Roberts; Alastair R Hawkins
The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genese.
Microbiology (Reading, England) 1996;142 ( Pt 6)():1477-90.
1996: K A Wheeler; Heather K Lamb; Alastair R Hawkins
Control of metabolic flux through the quinate pathway in Aspergillus nidulans.
The Biochemical journal 1996;315 ( Pt 1)():195-205.
1996: Heather K Lamb; J D Moore; J H Lakey; L J Levett; K A Wheeler; H Lago; J R Coggins; Alastair R Hawkins
Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme.
The Biochemical journal 1996;313 ( Pt 3)():941-50.
1996: I Levesley; G H Newton; Heather K Lamb; E van Schothorst; Raymond Dalgleish; A C Samson; C F Roberts; Alastair R Hawkins
Domain structure and function within the QUTA protein of Aspergillus nidulans: implications for the control of transcription.
Microbiology (Reading, England) 1996;142 ( Pt 1)():87-98.
1995: Stephen Lynn; J M Morgan; Heather K Lamb; Gerhard Meissner; James I Gillespie
Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.
FEBS letters 1995;372(1):6-12.
1995: Alastair R Hawkins; Heather K Lamb
The molecular biology of multidomain proteins. Selected examples.
European journal of biochemistry / FEBS 1995;232(1):7-18.
1994: Alastair R Hawkins; Heather K Lamb; A Radford; J D Moore
Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes.
Gene 1994;146(2):145-58.
1994: Alastair R Hawkins; Heather K Lamb; C F Roberts
Control of metabolic flux in the shikimate and quinate pathways.
Progress in industrial microbiology 1994;29():195-220.
1993: Alastair R Hawkins; Heather K Lamb; J D Moore; C F Roberts
Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme.
Gene 1993;136(1-2):49-54.
1993: Alastair R Hawkins; Heather K Lamb; J D Moore; Ian G Charles; C F Roberts
The pre-chorismate (shikimate) and quinate pathways in filamentous fungi: theoretical and practical aspects.
Journal of general microbiology 1993;139(12):2891-9.
1993: Alastair R Hawkins; J D Moore; Heather K Lamb
The molecular biology of the pentafunctional AROM protein.
Biochemical Society transactions 1993;21(1):181-6.
1992: J D Moore; Heather K Lamb; T Garbe; S Servos; Gordon Dougan; Ian G Charles; Alastair R Hawkins
Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis.
The Biochemical journal 1992;287 ( Pt 1)():173-81.
1992: Heather K Lamb; J P van den Hombergh; G H Newton; J D Moore; C F Roberts; Alastair R Hawkins
Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.
The Biochemical journal 1992;284 ( Pt 1)():181-7.
1992: Heather K Lamb; C F Roberts; Alastair R Hawkins
A second gene (qutH) within the Aspergillus nidulans-quinic-acid utilisation gene cluster encodes a protein with a putative zinc-cluster motif.
Gene 1992;112(2):219-24.
1992: Alastair R Hawkins; Heather K Lamb; C F Roberts
Structure of the Aspergillus nidulans qut repressor-encoding gene: implications for the regulation of transcription initiation.
Gene 1992;110(1):109-14.
1991: Heather K Lamb; C R Bagshaw; Alastair R Hawkins
In vivo overproduction of the pentafunctional arom polypeptide in Aspergillus nidulans affects metabolic flux in the quinate pathway.
Molecular & general genetics : MGG 1991;227(2):187-96.
1990: Heather K Lamb; Alastair R Hawkins; M Smith; I J Harvey; J Brown; G Turner; C F Roberts
Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans.
Molecular & general genetics : MGG 1990;223(1):17-23.
1990: Ian G Charles; Heather K Lamb; Derek Pickard; Gordon Dougan; Alastair R Hawkins
Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.
Journal of general microbiology 1990;136(2):353-8.
1988: Alastair R Hawkins; Heather K Lamb; M Smith; J W Keyte; C F Roberts
Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.
Molecular & general genetics : MGG 1988;214(2):224-31.