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Alan Lambowitz

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Jun Yao; David M Truong; Alan M Lambowitz
Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming.
Rick Russell; Inga Jarmoskaite; Alan M Lambowitz
Toward a molecular understanding of RNA remodeling by DEAD-box proteins.
Anna L Mallam; David J Sidote; Mark Del Campo; Benjamin Gilman; Alan M Lambowitz
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.

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All Publications

2013: Jun Yao; David M Truong; Alan M Lambowitz
Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming.
PLoS genetics 2013;9(4):e1003469.
2013: Rick Russell; Inga Jarmoskaite; Alan M Lambowitz
Toward a molecular understanding of RNA remodeling by DEAD-box proteins.
RNA biology 2013;10(1):44-55.
2012: Anna L Mallam; David J Sidote; Mark Del Campo; Benjamin Gilman; Alan M Lambowitz
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.
Nature 2012;490(7418):121-5.
2012: Travis B White; Alan M Lambowitz
The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms.
PLoS genetics 2012;8(2):e1002534.
2011: Georg Mohr; Kathryn G Turner; Rachel Z Wolf; Mark Del Campo; Benjamin Gilman; Alan M Lambowitz
High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p.
Journal of molecular biology 2011;413(5):952-72.
2011: Jeffrey P Potratz; Mark Del Campo; Alan M Lambowitz; Rachel Z Wolf; Rick Russell
ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo.
Journal of molecular biology 2011;411(3):661-79.
2011: Anna L Mallam; Rick Russell; Soenke Seifert; Pilar Tijerina; Mark Del Campo; Liang Guo; Inga Jarmoskaite; Alan M Lambowitz
Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12254-9.
2011: Paul J Paukstelis; Nandini Chari; Alan M Lambowitz; David Hoffman
NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing.
Biochemistry 2011;50(18):3816-26.
2010: Shan-Qing Gu; Xiaoxia Cui; Sijiong Mou; Sabine Mohr; Jun Yao; Alan M Lambowitz
Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase.
RNA (New York, N.Y.) 2010;16(4):732-47.
2010: Georg Mohr; Eman Ghanem; Alan M Lambowitz
Mechanisms used for genomic proliferation by thermophilic group II introns.
PLoS biology 2010;8(6):e1000391.
2009: Fanglei Zhuang; Marta Mastroianni; Travis B White; Alan M Lambowitz
Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joining for cDNA ligation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(43):18189-94.
2009: Mark Del Campo; Alan M Lambowitz
Structure of the Yeast DEAD box protein Mss116p reveals two wedges that crimp RNA.
Molecular cell 2009;35(5):598-609.
2009: Mark Del Campo; Alan M Lambowitz
Crystallization and preliminary X-ray diffraction of the DEAD-box protein Mss116p complexed with an RNA oligonucleotide and AMP-PNP.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):832-5.
2009: Dmitriy A Markov; Maria Savkina; Michael Anikin; Mark Del Campo; Karen Ecker; Alan M Lambowitz; Jon P De Gnore; William T McAllister
Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification.
Yeast (Chichester, England) 2009;26(8):423-40.
2009: Mark Del Campo; Sabine Mohr; Yue Jiang; Huijue Jia; Eckhard Jankowsky; Alan M Lambowitz
Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones.
Journal of molecular biology 2009;389(4):674-93.
2009: Fanglei Zhuang; Michael Karberg; Jiri Perutka; Alan M Lambowitz
EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting.
RNA (New York, N.Y.) 2009;15(3):432-49.
2008: Quentin Vicens; Paul J Paukstelis; Eric Westhof; Alan M Lambowitz; Thomas R Cech
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA (New York, N.Y.) 2008;14(10):2013-29.
2008: Junhua Zhao; Wei Niu; Jun Yao; Sabine Mohr; Edward M Marcotte; Alan M Lambowitz
Group II intron protein localization and insertion sites are affected by polyphosphate.
PLoS biology 2008;6(6):e150.
2008: Lixin Dai; Dinggeng Chai; Shan-Qing Gu; Jesse Gabel; Sergei Y Noskov; Forrest J H Blocker; Alan M Lambowitz; Steven Zimmerly
A three-dimensional model of a group II intron RNA and its interaction with the intron-encoded reverse transcriptase.
Molecular cell 2008;30(4):472-85.
2008: Paul J Paukstelis; Alan M Lambowitz
Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6010-5.
2008: Georg Mohr; Mark Del Campo; Sabine Mohr; Quansheng Yang; Huijue Jia; Eckhard Jankowsky; Alan M Lambowitz
Function of the C-terminal domain of the DEAD-box protein Mss116p analyzed in vivo and in vitro.
Journal of molecular biology 2008;375(5):1344-64.
2008: Paul J Paukstelis; Jui-Hui Chen; Elaine Chase; Alan M Lambowitz; Barbara L Golden
Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA.
Nature 2008;451(7174):94-7.
2008: Marta Mastroianni; Kazuo Watanabe; Travis B White; Fanglei Zhuang; Jamie Vernon; M Matsuura; John Wallingford; Alan M Lambowitz
Group II intron-based gene targeting reactions in eukaryotes.
PloS one 2008;3(9):e3121.
2007: Quansheng Yang; Mark Del Campo; Alan M Lambowitz; Eckhard Jankowsky
DEAD-box proteins unwind duplexes by local strand separation.
Molecular cell 2007;28(2):253-63.
2007: Mark Del Campo; Pilar Tijerina; Hari Bhaskaran; Sabine Mohr; Quansheng Yang; Eckhard Jankowsky; Rick Russell; Alan M Lambowitz
Do DEAD-box proteins promote group II intron splicing without unwinding RNA?
Molecular cell 2007;28(1):159-66.
2007: Jun Yao; Alan M Lambowitz
Gene targeting in gram-negative bacteria by use of a mobile group II intron ("Targetron") expressed from a broad-host-range vector.
Applied and environmental microbiology 2007;73(8):2735-43.
2007: Jacob K Grohman; Mark Del Campo; Hari Bhaskaran; Pilar Tijerina; Alan M Lambowitz; Rick Russell
Probing the mechanisms of DEAD-box proteins as general RNA chaperones: the C-terminal domain of CYT-19 mediates general recognition of RNA.
Biochemistry 2007;46(11):3013-22.
2007: Coralie Halls; Sabine Mohr; Mark Del Campo; Quansheng Yang; Eckhard Jankowsky; Alan M Lambowitz
Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity.
Journal of molecular biology 2007;365(3):835-55.
2006: James W Noah; Soyeun Park; Jacob T Whitt; Jiri Perutka; Wolfgang Frey; Alan M Lambowitz
Atomic force microscopy reveals DNA bending during group II intron ribonucleoprotein particle integration into double-stranded DNA.
Biochemistry 2006;45(41):12424-35.
2006: Jun Yao; Jin Zhong; Yuan Fang; Edward Geisinger; Richard novick; Alan M Lambowitz
Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing.
RNA (New York, N.Y.) 2006;12(7):1271-81.
2006: Sabine Mohr; Manabu Matsuura; Philip S Perlman; Alan M Lambowitz
A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3569-74.
2005: Junhua Zhao; Alan M Lambowitz
A bacterial group II intron-encoded reverse transcriptase localizes to cellular poles.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16133-40.
2005: Dorie Smith; Jin Zhong; Manabu Matsuura; Alan M Lambowitz; Marlene Belfort
Recruitment of host functions suggests a repair pathway for late steps in group II intron retrohoming.
Genes & development 2005;19(20):2477-87.
2005: John Patrick Jones; Monique N Kierlin; Robert G Coon; Jiri Perutka; Alan M Lambowitz; Bruce A Sullenger
Retargeting mobile group II introns to repair mutant genes.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):687-94.
2005: Colin Coros; Markus Landthaler; Carol Lyn Piazza; Arthur Beauregard; Donna Esposito; Jiri Perutka; Alan M Lambowitz; Marlene Belfort
Retrotransposition strategies of the Lactococcus lactis Ll.LtrB group II intron are dictated by host identity and cellular environment.
Molecular microbiology 2005;56(2):509-24.
2005: Paul J Paukstelis; Robert Coon; Lakshmi Madabusi; Jacek Nowakowski; Arthur Monzingo; Jon Robertus; Alan M Lambowitz
A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface.
Molecular cell 2005;17(3):417-28.
2005: Hon-Ren Huang; Claire E Rowe; Sabine Mohr; Yue Jiang; Alan M Lambowitz; Philip S Perlman
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):163-8.
2005: Jun Yao; Jin Zhong; Alan M Lambowitz
Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library.
Nucleic acids research 2005;33(10):3351-62.
2005: Forrest J H Blocker; Georg Mohr; Lori H Conlan; Li Qi; Marlene Belfort; Alan M Lambowitz
Domain structure and three-dimensional model of a group II intron-encoded reverse transcriptase.
RNA (New York, N.Y.) 2005;11(1):14-28.
2004: Kazuo Watanabe; Alan M Lambowitz
High-affinity binding site for a group II intron-encoded reverse transcriptase/maturase within a stem-loop structure in the intron RNA.
RNA (New York, N.Y.) 2004;10(9):1433-43.
2004: Xiaoxia Cui; Manabu Matsuura; Qin Wang; Hongwen Ma; Alan M Lambowitz
A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing.
Journal of molecular biology 2004;340(2):211-31.
2004: Xin Chen; Georg Mohr; Alan M Lambowitz
The Neurospora crassa CYT-18 protein C-terminal RNA-binding domain helps stabilize interdomain tertiary interactions in group I introns.
RNA (New York, N.Y.) 2004;10(4):634-44.
2004: Jiri Perutka; Wenjun Wang; David Goerlitz; Alan M Lambowitz
Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes.
Journal of molecular biology 2004;336(2):421-39.
2004: Alan M Lambowitz; Steven Zimmerly
Mobile group II introns.
Annual review of genetics 2004;38():1-35.
2003: Hon-Ren Huang; Michael Y Chao; Barbara Armstrong; Yong Wang; Alan M Lambowitz; Philip S Perlman
The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.
Molecular and cellular biology 2003;23(23):8809-19.
2003: James W Noah; Alan M Lambowitz
Effects of maturase binding and Mg2+ concentration on group II intron RNA folding investigated by UV cross-linking.
Biochemistry 2003;42(43):12466-80.
2003: Jin Zhong; Alan M Lambowitz
Group II intron mobility using nascent strands at DNA replication forks to prime reverse transcription.
The EMBO journal 2003;22(17):4555-65.
2003: Estefanía Muñoz-Adelantado; Joseph San Filippo; Francisco Martinez-Abarca; Fernando M García-Rodríguez; Alan M Lambowitz; Nicolás Toro
Mobility of the Sinorhizobium meliloti group II intron RmInt1 occurs by reverse splicing into DNA, but requires an unknown reverse transcriptase priming mechanism.
Journal of molecular biology 2003;327(5):931-43.
2003: Jin Zhong; Michael Karberg; Alan M Lambowitz
Targeted and random bacterial gene disruption using a group II intron (targetron) vector containing a retrotransposition-activated selectable marker.
Nucleic acids research 2003;31(6):1656-64.
2003: Yasunori Aizawa; Qing Xiang; Alan M Lambowitz; Anna Marie Pyle
The pathway for DNA recognition and RNA integration by a group II intron retrotransposon.
Molecular cell 2003;11(3):795-805.
2003: Courtney L Frazier; Joseph San Filippo; Alan M Lambowitz; david mills
Genetic manipulation of Lactococcus lactis by using targeted group II introns: generation of stable insertions without selection.
Applied and environmental microbiology 2003;69(2):1121-8.
2003: Georg Mohr; Alan M Lambowitz
Putative proteins related to group II intron reverse transcriptase/maturases are encoded by nuclear genes in higher plants.
Nucleic acids research 2003;31(2):647-52.
2002: Joseph San Filippo; Alan M Lambowitz
Characterization of the C-terminal DNA-binding/DNA endonuclease region of a group II intron-encoded protein.
Journal of molecular biology 2002;324(5):933-51.
2002: Sabine Mohr; John M Stryker; Alan M Lambowitz
A DEAD-box protein functions as an ATP-dependent RNA chaperone in group I intron splicing.
Cell 2002;109(6):769-79.
2002: Ravindra N Singh; Roland J Saldanha; Lisa M D'Souza; Alan M Lambowitz
Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation.
Journal of molecular biology 2002;318(2):287-303.
2002: Christopher A Myers; Birte Kuhla; Stephen Cusack; Alan M Lambowitz
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2630-5.
2001: M Matsuura; James W Noah; Alan M Lambowitz
Mechanism of maturase-promoted group II intron splicing.
The EMBO journal 2001;20(24):7259-70.
2001: Michael Karberg; H Guo; Jin Zhong; R Coon; Jiri Perutka; Alan M Lambowitz
Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria.
Nature biotechnology 2001;19(12):1162-7.
2001: Lorna Dickson; Hon-Ren Huang; Lu Liu; M Matsuura; Alan M Lambowitz; Philip S Perlman
Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13207-12.
2001: N N Singh; Alan M Lambowitz
Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference.
Journal of molecular biology 2001;309(2):361-86.
2001: MG Caprara; C A Myers; Alan M Lambowitz
Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) with the group I intron P4-P6 domain. Thermodynamic analysis and the role of metal ions.
Journal of molecular biology 2001;308(2):165-90.
2001: Georg Mohr; R Rennard; A D Cherniack; J Stryker; Alan M Lambowitz
Function of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase in RNA splicing. Role of the idiosyncratic N-terminal extension and different modes of interaction with different group I introns.
Journal of molecular biology 2001;307(1):75-92.
2000: R Eskes; Lu Liu; H Ma; M Y Chao; Lorna Dickson; Alan M Lambowitz; Philip S Perlman
Multiple homing pathways used by yeast mitochondrial group II introns.
Molecular and cellular biology 2000;20(22):8432-46.
2000: Xin Chen; Robin R Gutell; Alan M Lambowitz
Function of tyrosyl-tRNA synthetase in splicing group I introns: an induced-fit model for binding to the P4-P6 domain based on analysis of mutations at the junction of the P4-P6 stacked helices.
Journal of molecular biology 2000;301(2):265-83.
2000: H Guo; Michael Karberg; M Long; J P Jones; Bruce A Sullenger; Alan M Lambowitz
Group II introns designed to insert into therapeutically relevant DNA target sites in human cells.
Science (New York, N.Y.) 2000;289(5478):452-7.
2000: Sabine Mohr; L A Wanner; H Bertrand; Alan M Lambowitz
Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid.
Nucleic acids research 2000;28(13):1514-24.
2000: Sabine Mohr; L A Wanner; H Bertrand; Alan M Lambowitz
Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid.
Nucleic acids research 2000;28(7):1514-24.
2000: Georg Mohr; D Smith; Marlene Belfort; Alan M Lambowitz
Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences.
Genes & development 2000;14(5):559-73.
1999: H Wank; Joseph San Filippo; R N Singh; M Matsuura; Alan M Lambowitz
A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA.
Molecular cell 1999;4(2):239-50.
1999: Roland J Saldanha; B Chen; H Wank; M Matsuura; J Edwards; Alan M Lambowitz
RNA and protein catalysis in group II intron splicing and mobility reactions using purified components.
Biochemistry 1999;38(28):9069-83.
1999: Steven Zimmerly; John V Moran; Philip S Perlman; Alan M Lambowitz
Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA.
Journal of molecular biology 1999;289(3):473-90.
1998: J Yang; G Mohr; Philip S Perlman; Alan M Lambowitz
Group II intron mobility in yeast mitochondria: target DNA-primed reverse transcription activity of aI1 and reverse splicing into DNA transposition sites in vitro.
Journal of molecular biology 1998;282(3):505-23.
1998: Benoit Cousineau; Dorie Smith; S Lawrence-Cavanagh; J E Mueller; J Yang; david mills; D Manias; G Dunny; Alan M Lambowitz; Marlene Belfort
Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination.
Cell 1998;94(4):451-62.
1997: H Guo; Steven Zimmerly; Philip S Perlman; Alan M Lambowitz
Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA.
The EMBO journal 1997;16(22):6835-48.
1997: M Matsuura; Roland J Saldanha; H Ma; H Wank; J Yang; G Mohr; S Cavanagh; G M Dunny; Marlene Belfort; Alan M Lambowitz
A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron.
Genes & development 1997;11(21):2910-24.
1997: B Chen; Alan M Lambowitz
De novo and DNA primer-mediated initiation of cDNA synthesis by the mauriceville retroplasmid reverse transcriptase involve recognition of a 3' CCA sequence.
Journal of molecular biology 1997;271(3):311-32.
1997: C C Chiang; Alan M Lambowitz
The Mauriceville retroplasmid reverse transcriptase initiates cDNA synthesis de novo at the 3' end of tRNAs.
Molecular and cellular biology 1997;17(8):4526-35.
1997: R Eskes; J Yang; Alan M Lambowitz; Philip S Perlman
Mobility of yeast mitochondrial group II introns: engineering a new site specificity and retrohoming via full reverse splicing.
Cell 1997;88(6):865-74.
1997: G J Wallweber; S Mohr; R Rennard; MG Caprara; Alan M Lambowitz
Characterization of Neurospora mitochondrial group I introns reveals different CYT-18 dependent and independent splicing strategies and an alternative 3' splice site for an intron ORF.
RNA (New York, N.Y.) 1997;3(2):114-31.
1996: M G Caprara; V Lehnert; Alan M Lambowitz; E Westhof
A tyrosyl-tRNA synthetase recognizes a conserved tRNA-like structural motif in the group I intron catalytic core.
Cell 1996;87(6):1135-45.
1996: C A Myers; G J Wallweber; R Rennard; Y Kemel; M G Caprara; G Mohr; Alan M Lambowitz
A tyrosyl-tRNA synthetase suppresses structural defects in the two major helical domains of the group I intron catalytic core.
Journal of molecular biology 1996;262(2):87-104.
1996: R Saldanha; A Ellington; Alan M Lambowitz
Analysis of the CYT-18 protein binding site at the junction of stacked helices in a group I intron RNA by quantitative binding assays and in vitro selection.
Journal of molecular biology 1996;261(1):23-42.
1996: J Yang; Steven Zimmerly; Philip S Perlman; Alan M Lambowitz
Efficient integration of an intron RNA into double-stranded DNA by reverse splicing.
Nature 1996;381(6580):332-5.
1996: M G Caprara; G Mohr; Alan M Lambowitz
A tyrosyl-tRNA synthetase protein induces tertiary folding of the group I intron catalytic core.
Journal of molecular biology 1996;257(3):512-31.
1995: Steven Zimmerly; H Guo; R Eskes; J Yang; Philip S Perlman; Alan M Lambowitz
A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility.
Cell 1995;83(4):529-38.
1995: Steven Zimmerly; H Guo; Philip S Perlman; Alan M Lambowitz
Group II intron mobility occurs by target DNA-primed reverse transcription.
Cell 1995;82(4):545-54.
1995: John V Moran; Steven Zimmerly; R Eskes; J C Kennell; Alan M Lambowitz; Ronald A Butow; Philip S Perlman
Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements.
Molecular and cellular biology 1995;15(5):2828-38.
1995: J C Kennell; B J Saville; S Mohr; Martin Kuiper; J R Sabourin; Richard A Collins; Alan M Lambowitz
The VS catalytic RNA replicates by reverse transcription as a satellite of a retroplasmid.
Genes & development 1995;9(3):294-303.
1995: R J Saldanha; S S Patel; R Surendran; J C Lee; Alan M Lambowitz
Involvement of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing. A new method for purifying the protein and characterization of physical and enzymatic properties pertinent to splicing.
Biochemistry 1995;34(4):1275-87.
1994: C C Chiang; J C Kennell; L A Wanner; Alan M Lambowitz
A mitochondrial retroplasmid integrates into mitochondrial DNA by a novel mechanism involving the synthesis of a hybrid cDNA and homologous recombination.
Molecular and cellular biology 1994;14(10):6419-32.
1994: G Mohr; M G Caprara; Q Guo; Alan M Lambowitz
A tyrosyl-tRNA synthetase can function similarly to an RNA structure in the Tetrahymena ribozyme.
Nature 1994;370(6485):147-50.
1994: J C Kennell; H Wang; Alan M Lambowitz
The Mauriceville plasmid of Neurospora spp. uses novel mechanisms for initiating reverse transcription in vivo.
Molecular and cellular biology 1994;14(5):3094-107.
1993: H Wang; Alan M Lambowitz
The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor.
Cell 1993;75(6):1071-81.
1993: G Mohr; Philip S Perlman; Alan M Lambowitz
Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function.
Nucleic acids research 1993;21(22):4991-7.
1993: H Wang; Alan M Lambowitz
Reverse transcription of the Mauriceville plasmid of Neurospora. Lack of ribonuclease H activity associated with the reverse transcriptase and possible use of mitochondrial ribonuclease H.
The Journal of biological chemistry 1993;268(25):18951-9.
1993: J C Kennell; John V Moran; Philip S Perlman; Ronald A Butow; Alan M Lambowitz
Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria.
Cell 1993;73(1):133-46.
1993: R Saldanha; G Mohr; M Belfort; Alan M Lambowitz
Group I and group II introns.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(1):15-24.
1992: H Wang; J C Kennell; Martin Kuiper; J R Sabourin; R Saldanha; Alan M Lambowitz
The Mauriceville plasmid of Neurospora crassa: characterization of a novel reverse transcriptase that begins cDNA synthesis at the 3' end of template RNA.
Molecular and cellular biology 1992;12(11):5131-44.
1992: Q Guo; Alan M Lambowitz
A tyrosyl-tRNA synthetase binds specifically to the group I intron catalytic core.
Genes & development 1992;6(8):1357-72.
1992: G Mohr; A Zhang; J A Gianelos; M Belfort; Alan M Lambowitz
The neurospora CYT-18 protein suppresses defects in the phage T4 td intron by stabilizing the catalytically active structure of the intron core.
Cell 1992;69(3):483-94.
1992: Frank E Nargang; S Pande; J C Kennell; Robert Akins; Alan M Lambowitz
Evidence that a 1.6 kilobase region of Neurospora mtDNA was derived by insertion of part of the LaBelle mitochondrial plasmid.
Nucleic acids research 1992;20(5):1101-8.
1992: B Turcq; K F Dobinson; N Serizawa; Alan M Lambowitz
A protein required for RNA processing and splicing in Neurospora mitochondria is related to gene products involved in cell cycle protein phosphatase functions.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1676-80.
1991: G Mohr; Alan M Lambowitz
Integration of a group I intron into a ribosomal RNA sequence promoted by a tyrosyl-tRNA synthetase.
Nature 1991;354(6349):164-7.
1991: A R Kubelik; B Turcq; Alan M Lambowitz
The Neurospora crassa cyt-20 gene encodes cytosolic and mitochondrial valyl-tRNA synthetases and may have a second function in addition to protein synthesis.
Molecular and cellular biology 1991;11(8):4022-35.
1991: J D Kittle; G Mohr; J A Gianelos; H Wang; Alan M Lambowitz
The Neurospora mitochondrial tyrosyl-tRNA synthetase is sufficient for group I intron splicing in vitro and uses the carboxy-terminal tRNA-binding domain along with other regions.
Genes & development 1991;5(6):1009-21.
1991: U Schulte; Alan M Lambowitz
The LaBelle mitochondrial plasmid of Neurospora intermedia encodes a novel DNA polymerase that may be derived from a reverse transcriptase.
Molecular and cellular biology 1991;11(3):1696-706.
1991: Q B Guo; Robert Akins; G Garriga; Alan M Lambowitz
Structural analysis of the Neurospora mitochondrial large rRNA intron and construction of a mini-intron that shows protein-dependent splicing.
The Journal of biological chemistry 1991;266(3):1809-19.
1990: Alan M Lambowitz; P S Perlman
Involvement of aminoacyl-tRNA synthetases and other proteins in group I and group II intron splicing.
Trends in biochemical sciences 1990;15(11):440-4.
1990: Robert Akins; Alan M Lambowitz
Analysis of large deletions in the Mauriceville and Varkud mitochondrial plasmids of Neurospora.
Current genetics 1990;18(4):365-9.
1990: A D Cherniack; G Garriga; J D Kittle; Robert Akins; Alan M Lambowitz
Function of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases.
Cell 1990;62(4):745-55.
1990: M T Kuiper; J R Sabourin; Alan M Lambowitz
Identification of the reverse transcriptase encoded by the Mauriceville and Varkud mitochondrial plasmids of Neurospora.
The Journal of biological chemistry 1990;265(12):6936-43.
1990: A R Kubelik; J C Kennell; Robert Akins; Alan M Lambowitz
Identification of Neurospora mitochondrial promoters and analysis of synthesis of the mitochondrial small rRNA in wild-type and the promoter mutant [poky].
The Journal of biological chemistry 1990;265(8):4515-26.
1989: M E Drygas; Alan M Lambowitz; Frank E Nargang
Cloning and analysis of the Neurospora crassa gene for cytochrome c heme lyase.
The Journal of biological chemistry 1989;264(30):17897-906.
1989: J C Kennell; Alan M Lambowitz
Development of an in vitro transcription system for Neurospora crassa mitochondrial DNA and identification of transcription initiation sites.
Molecular and cellular biology 1989;9(9):3603-13.
1989: K F Dobinson; M Henderson; R L Kelley; Richard A Collins; Alan M Lambowitz
Mutations in nuclear gene cyt-4 of Neurospora crassa result in pleiotropic defects in processing and splicing of mitochondrial RNAs.
Genetics 1989;123(1):97-108.
1989: A L Majumder; Robert Akins; J G Wilkinson; R L Kelley; A J Snook; Alan M Lambowitz
Involvement of tyrosyl-tRNA synthetase in splicing of group I introns in Neurospora crassa mitochondria: biochemical and immunochemical analyses of splicing activity.
Molecular and cellular biology 1989;9(5):2089-104.
1989: Alan M Lambowitz; J R Sabourin; H Bertrand; R Nickels; L McIntosh
Immunological identification of the alternative oxidase of Neurospora crassa mitochondria.
Molecular and cellular biology 1989;9(3):1362-4.
1989: Alan M Lambowitz
Infectious introns.
Cell 1989;56(3):323-6.
1989: Robert Akins; R L Kelley; Alan M Lambowitz
Characterization of mutant mitochondrial plasmids of Neurospora spp. that have incorporated tRNAs by reverse transcription.
Molecular and cellular biology 1989;9(2):678-91.
1988: M T Kuiper; Alan M Lambowitz
A novel reverse transcriptase activity associated with mitochondrial plasmids of Neurospora.
Cell 1988;55(4):693-704.
1988: Robert Akins; D M Grant; L L Stohl; Drell A Bottorff; Frank E Nargang; Alan M Lambowitz
Nucleotide sequence of the Varkud mitochondrial plasmid of Neurospora and synthesis of a hybrid transcript with a 5' leader derived from mitochondrial RNA.
Journal of molecular biology 1988;204(1):1-25.
1986: Robert Akins; R L Kelley; Alan M Lambowitz
Mitochondrial plasmids of Neurospora: integration into mitochondrial DNA and evidence for reverse transcription in mitochondria.
Cell 1986;47(4):505-16.
1986: G Garriga; Alan M Lambowitz
Protein-dependent splicing of a group I intron in ribonucleoprotein particles and soluble fractions.
Cell 1986;46(5):669-80.
1986: G Garriga; Alan M Lambowitz; T Inoue; Thomas R Cech
Mechanism of recognition of the 5' splice site in self-splicing group I introns.
Nature 1986;322(6074):86-9.
1986: R D Vincent; R Goewert; William Goldman; GS Kobayashi; Alan M Lambowitz; G Medoff
Classification of Histoplasma capsulatum isolates by restriction fragment polymorphisms.
Journal of bacteriology 1986;165(3):813-8.
1986: Alan M Lambowitz; Robert Akins; R L Kelley; S Pande; Frank E Nargang
Mitochondrial plasmids of Neurospora and other filamentous fungi.
Basic life sciences 1986;40():83-92.
1984: G Garriga; Alan M Lambowitz
RNA splicing in neurospora mitochondria: self-splicing of a mitochondrial intron in vitro.
Cell 1984;39(3 Pt 2):631-41.
1984: Frank E Nargang; J B Bell; L L Stohl; Alan M Lambowitz
The DNA sequence and genetic organization of a Neurospora mitochondrial plasmid suggest a relationship to introns and mobile elements.
Cell 1984;38(2):441-53.
1984: L L Stohl; Robert Akins; Alan M Lambowitz
Characterization of deletion derivatives of an autonomously replicating Neurospora plasmid.
Nucleic acids research 1984;12(15):6169-78.
1984: G Garriga; H Bertrand; Alan M Lambowitz
RNA splicing in Neurospora mitochondria: nuclear mutants defective in both splicing and 3' end synthesis of the large rRNA.
Cell 1984;36(3):623-34.
1983: G Garriga; Alan M Lambowitz
RNA splicing in Neurospora mitochondria. The large rRNA intron contains a noncoded, 5'-terminal guanosine residue.
The Journal of biological chemistry 1983;258(24):14745-8.
1983: L L Stohl; Alan M Lambowitz
A colony filter-hybridization procedure for the filamentous fungus Neurospora crassa.
Analytical biochemistry 1983;134(1):82-5.
1983: Frank E Nargang; J B Bell; L L Stohl; Alan M Lambowitz
A family of repetitive palindromic sequences found in Neurospora mitochondrial DNA is also found in a mitochondrial plasmid DNA.
The Journal of biological chemistry 1983;258(7):4257-60.
1983: L L Stohl; Alan M Lambowitz
Construction of a shuttle vector for the filamentous fungus Neurospora crassa.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(4):1058-62.
1982: H Bertrand; P Bridge; R A Collins; G Garriga; Alan M Lambowitz
RNA splicing in Neurospora mitochondria. Characterization of new nuclear mutants with defects in splicing the mitochondrial large rRNA.
Cell 1982;29(2):517-26.
1982: L L Stohl; R A Collins; M D Cole; Alan M Lambowitz
Characterization of two new plasmid DNAs found in mitochondria of wild-type Neurospora intermedia strains.
Nucleic acids research 1982;10(5):1439-58.
1981: M F Grimm; M D Cole; Alan M Lambowitz
Ribonucleic acid splicing in Neurospora Mitochondria: secondary structure of the 35S ribosomal precursor ribonucleic acid investigated by digestion with ribonuclease III and by electron microscopy.
Biochemistry 1981;20(10):2836-42.
1981: R A Collins; L L Stohl; M D Cole; Alan M Lambowitz
Characterization of a novel plasmid DNA found in mitochondria of N. crassa.
Cell 1981;24(2):443-52.
1981: M R Green; M F Grimm; R R Goewert; R A Collins; M D Cole; Alan M Lambowitz; J E Heckman; S Yin; U L RajBhandary
Transcripts and processing patterns for the ribosomal RNA and transfer RNA region of Neurospora crassa mitochondrial DNA.
The Journal of biological chemistry 1981;256(4):2027-34.
1980: H Bertrand; R A Collins; L L Stohl; R R Goewert; Alan M Lambowitz
Deletion mutants of Neurospora crassa mitochondrial DNA and their relationship to the "stop-start" growth phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(10):6032-6.