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Günter Lambrecht
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60
Mutschler, Ernst
17
Waelbroeck, Magali
12
Nickel, Peter
11
Schmalzing, Günther
10
Tastenoy, Michèle
9
Rettinger, Jürgen
7
Kassack, Matthias
6
Hildebrandt, Caren
5
Ganso, Matthias
5
Braun, Kirsten
5
Ullmann, Heiko
4
Bäumert, Hans
4
Damer, S
4
Eltze, Manfrid
3
Dannhardt, Gerd
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All Publications
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2006: Hausmann Ralf; Rettinger Jürgen; Gerevich Zoltan; Meis Sabine; Kassack Matthias U; Illes Peter; Lambrecht Günter; Schmalzing Günther
The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Molecular pharmacology 2006;69(6):2058-67.
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2005: Horner Susanne; Menke Kirsten; Hildebrandt Caren; Kassack Matthias U; Nickel Peter; Ullmann Heiko; Mahaut-Smith Martyn P; Lambrecht Günter
The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range.
Naunyn-Schmiedeberg's archives of pharmacology 2005;372(1):1-13.
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2005: Rettinger Jürgen; Braun Kirsten; Hochmann Henrike; Kassack Matthias U; Ullmann Heiko; Nickel Peter; Schmalzing Günther; Lambrecht Günter
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist.
Neuropharmacology 2005;48(3):461-8.
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2004: Kassack Matthias U; Braun Kirsten; Ganso Matthias; Ullmann Heiko; Nickel Peter; Böing Barbara; Müller Gregor; Lambrecht Günter
Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist.
European journal of medicinal chemistry 2004;39(4):345-57.
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2003: Hülsmann Martin; Nickel Peter; Kassack Matthias; Schmalzing Günther; Lambrecht Günter; Markwardt Fritz
NF449, a novel picomolar potency antagonist at human P2X1 receptors.
European journal of pharmacology 2003;470(1-2):1-7.
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2003: Böhme Thomas M; Keim Christine; Kreutzmann Kai; Linder Matthias; Dingermann Theo; Dannhardt Gerd; Mutschler Ernst; Lambrecht Günter
Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.
Journal of medicinal chemistry 2003;46(5):856-67.
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2002: Rost Sylvia; Daniel Christoph; Schulze-Lohoff Eckhard; Bäumert Hans G; Lambrecht Günter; Hugo Christian
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis.
Kidney international 2002;62(5):1659-71.
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2002: Lambrecht Günter; Braun Kirsten; Damer MiSusannechelle; Ganso Matthias; Hildebrandt Caren; Ullmann Heiko; Kassack Matthias U; Nickel Peter
Structure-activity relationships of suramin and pyridoxal-5'-phosphate derivatives as P2 receptor antagonists.
Current pharmaceutical design 2002;8(26):2371-99.
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2001: Braun K; Rettinger J; Ganso M; Kassack M; Hildebrandt C; Ullmann H; Nickel P; Schmalzing G; Lambrecht G
NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(3):285-90.
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2001: Böhme T M; Keim C; Dannhardt G; Mutschler E; Lambrecht G
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.
Bioorganic & medicinal chemistry letters 2001;11(9):1241-3.
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2000: Lambrecht G
Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):340-50.
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2000: Rettinger J; Schmalzing G; Damer S; Müller G; Nickel P; Lambrecht G
The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor.
Neuropharmacology 2000;39(11):2044-53.
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2000: Lambrecht G; Ganso M; Bäumert H G; Spatz-Kümbel G; Hildebrandt C; Braun K; Mutschler E
The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y(1) receptor-mediated responses.
Journal of the autonomic nervous system 2000;81(1-3):171-7.
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2000: Tumiatti V; Wehrle J; Hildebrandt C; Moser U; Dannhardt G; Mutschler E; Lambrecht G
Muscarinic properties of compounds related to arecaidine propargyl ester.
Arzneimittel-Forschung 2000;50(1):11-5.
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2000: Lambrecht G; Rettinger J; Bäumert H G; Czeche S; Damer S; Ganso M; Hildebrandt C; Niebel B; Spatz-Kümbel G; Schmalzing G; Mutschler E
The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X(1) receptors.
European journal of pharmacology 2000;387(3):R19-21.
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2000: Klapperstück M; Büttner C; Nickel P; Schmalzing G; Lambrecht G; Markwardt F
Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors.
European journal of pharmacology 2000;387(3):245-52.
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1999: Soto F; Lambrecht G; Nickel P; Stühmer W; Busch A E
Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors.
Neuropharmacology 1999;38(1):141-9.
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1999: Lambrecht G; Damer S; Niebel B; Czeche S; Nickel P; Rettinger J; Schmalzing G; Mutschler E
Novel ligands for P2 receptor subtypes in innervated tissues.
Progress in brain research 1999;120():107-17.
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1999: Nicke A; Rettinger J; Büttner C; Eichele A; Lambrecht G; Schmalzing G
Evolving view of quaternary structures of ligand-gated ion channels.
Progress in brain research 1999;120():61-80.
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1999: Lambrecht G; Gross J; Mutschler E
Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle.
Life sciences 1999;64(6-7):403-10.
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1998: Nicke A; Bäumert H G; Rettinger J; Eichele A; Lambrecht G; Mutschler E; Schmalzing G
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.
The EMBO journal 1998;17(11):3016-28.
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1998: Damer S; Niebel B; Czeche S; Nickel P; Ardanuy U; Schmalzing G; Rettinger J; Mutschler E; Lambrecht G
NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
European journal of pharmacology 1998;350(1):R5-6.
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1998: Tränkle C; Andresen I; Lambrecht G; Mohr K
M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.
Molecular pharmacology 1998;53(2):304-12.
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1997: Weiser M; Mutschler E; Lambrecht G
Characterization of postjunctional muscarinic receptors mediating contraction in rat anococcygeus muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(5):671-7.
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1997: Gross J; Mutschler E; Lambrecht G
Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(4):505-16.
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1997: Langer K; Lambrecht G; Moser U; Mutschler E; Kreuter J
Quantitative colorimetric and gas chromatographic determination of arecaidine propargyl ester.
Journal of chromatography. B, Biomedical sciences and applications 1997;692(2):345-50.
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1997: Ziyal R; Ziganshin A U; Nickel P; Ardanuy U; Mutschler E; Lambrecht G; Burnstock G
Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery.
British journal of pharmacology 1997;120(5):954-60.
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1996: Lambrecht G
Design and pharmacology of selective P2-purinoceptor antagonists.
Journal of autonomic pharmacology 1996;16(6):341-4.
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1996: Waelbroeck M; Lazareno S; Pfaff O; Friebe T; Tastenoy M; Mutschler E; Lambrecht G
Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes.
British journal of pharmacology 1996;119(7):1319-30.
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1996: Waelbroeck M; Hou X; Wehrle J; Mutschler E; Van Tilburg E; Menge W; Timmerman H; Lambrecht G
Stereoselective interaction of uncharged esters at four muscarinic receptor subtypes.
European journal of pharmacology 1996;303(3):221-6.
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1995: Pfaff O; Hildebrandt C; Waelbroeck M; Hou X; Moser U; Mutschler E; Lambrecht G
The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist.
European journal of pharmacology 1995;286(3):229-40.
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1995: Windscheif U; Radziwon P; Breddin H K; Bäumert H G; Lambrecht G; Mutschler E
Two different inhibitory effects of pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid on adenosine diphosphate-induced human platelet aggregation.
Arzneimittel-Forschung 1995;45(9):994-7.
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1995: Windscheif U; Pfaff O; Ziganshin A U; Hoyle C H; Bäumert H G; Mutschler E; Burnstock G; Lambrecht G
Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum.
British journal of pharmacology 1995;115(8):1509-17.
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1995: Moser U; Gubitz C; Galvan M; Immel-Sehr A; Lambrecht G; Mutshcler E
Aliphatic and heterocyclic analogues of arecaidine propargyl ester. Structure-activity relationships of mono- and bivalent ligands at muscarinic M1 (M4), M2 and M3 receptor subtypes.
Arzneimittel-Forschung 1995;45(4):449-55.
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1995: Mutschler E; Moser U; Wess J; Lambrecht G
Muscarinic receptor subtypes--pharmacological, molecular biological and therapeutical aspects.
Pharmaceutica acta Helvetiae 1995;69(4):243-58.
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1995: Lambrecht G; Gross J; Hacksell U; Hermanni U; Hildebrandt C; Hou X; Moser U; Nilsson B M; Pfaff O; Waelbroeck M
The design and pharmacology of novel selective muscarinic agonists and antagonists.
Life sciences 1995;56(11-12):815-22.
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1994: Windscheif U; Ralevic V; Bäumert H G; Mutschler E; Lambrecht G; Burnstock G
Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x-purinoceptors.
British journal of pharmacology 1994;113(3):1015-21.
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1994: Zimmer A; Mutschler E; Lambrecht G; Mayer D; Kreuter J
Pharmacokinetic and pharmacodynamic aspects of an ophthalmic pilocarpine nanoparticle-delivery-system.
Pharmaceutical research 1994;11(10):1435-42.
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1994: Grimm U; Moser U; Mutschler E; Lambrecht G
Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists.
Die Pharmazie 1994;49(10):711-26.
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1994: Waelbroeck M; Camus J; Tastenoy M; Feifel R; Mutschler E; Tacke R; Strohmann C; Rafeiner K; Rodrigues de Miranda J F; Lambrecht G
Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes.
British journal of pharmacology 1994;112(2):505-14.
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1994: Ziganshin A U; Hoyle C H; Lambrecht G; Mutschler E; Bümert H G; Burnstock G
Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels.
British journal of pharmacology 1994;111(3):923-9.
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1994: Grimm U; Fuder H; Moser U; Bümert H G; Mutschler E; Lambrecht G
Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(1):1-10.
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1993: Ziganshin A U; Hoyle C H; Bo X; Lambrecht G; Mutschler E; Bäumert H G; Burnstock G
PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder.
British journal of pharmacology 1993;110(4):1491-5.
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1993: Eltze M; Ullrich B; Mutschler E; Moser U; Bungardt E; Friebe T; Gubitz C; Tacke R; Lambrecht G
Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney.
European journal of pharmacology 1993;238(2-3):343-55.
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1993: Waelbroeck M; Camus J; Tastenoy M; Lambrecht G; Mutschler E; Kropfgans M; Sperlich J; Wiesenberger F; Tacke R; Christophe J
Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type.
British journal of pharmacology 1993;109(2):360-70.
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1993: Lambrecht G; Moser U; Grimm U; Pfaff O; Hermanni U; Hildebrandt C; Waelbroeck M; Christophe J; Mutschler E
New functionally selective muscarinic agonists.
Life sciences 1993;52(5-6):481-8.
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1992: Rauwald H W; Kober M; Mutschler E; Lambrecht G
Cryptolepis sanguinolenta: antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors.
Planta medica 1992;58(6):486-8.
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1992: Bungardt E; Buschauer A; Moser U; Schunack W; Lambrecht G; Mutschler E
Histamine H1 receptors mediate vasodilation in guinea-pig ileum resistance vessels: characterization with computer-assisted videomicroscopy and new selective agonists.
European journal of pharmacology 1992;221(1):91-8.
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1992: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Schjelderup L; Aasen A; Lambrecht G; Christophe J
Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology 1992;227(1):33-42.
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1992: Lambrecht G; Friebe T; Grimm U; Windscheif U; Bungardt E; Hildebrandt C; Bäumert H G; Spatz-Kümbel G; Mutschler E
PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.
European journal of pharmacology 1992;217(2-3):217-9.
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1992: Bungardt E; Vockert E; Feifel R; Moser U; Tacke R; Mutschler E; Lambrecht G; Surprenant A
Characterization of muscarinic receptors mediating vasodilation in guinea-pig ileum submucosal arterioles by the use of computer-assisted videomicroscopy.
European journal of pharmacology 1992;213(1):53-61.
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1992: Eltze M; Mutschler E; Lambrecht G
Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3.
European journal of pharmacology 1992;211(3):283-93.
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1991: Dörje F; Rettenmayr N M; Mutschler E; Lambrecht G
Effect of extracellular calcium concentration on potency of muscarinic agonists at M1 and M2 receptors in rabbit vas deferens.
European journal of pharmacology 1991;203(3):417-20.
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1991: Feifel R; Rodrigues de Miranda J F; Strohmann C; Tacke R; Aasen A J; Mutschler E; Lambrecht G
Selective labelling of muscarinic M1 receptors in calf superior cervical ganglia by [3H](+/-)-telenzepine.
European journal of pharmacology 1991;195(1):115-23.
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1991: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects.
European journal of pharmacology 1991;206(2):95-103.
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1991: Dörje F; Wess J; Lambrecht G; Tacke R; Mutschler E; Brann M R
Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1991;256(2):727-33.
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1991: Wess J; Lambrecht G; Mutschler E; Brann M R; Dörje F
Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations.
British journal of pharmacology 1991;102(1):246-50.
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1991: Waelbroeck M; Camus J; Tastenoy M; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors.
Chirality 1991;3(2):118-23.
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1990: Dörje F; Friebe T; Tacke R; Mutschler E; Lambrecht G
Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(3):284-9.
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1990: Waelbroeck M; Camus J; Tastenoy M; Lambrecht G; Mutschler E; Tacke R; Christophe J
Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4.
European journal of pharmacology 1990;189(2-3):135-42.
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1990: Rettenmayr N M; Rodrigues de Miranda J F; Rijntjes N V; Russel F G; van Ginneken C A; Strohmann C; Tacke R; Lambrecht G; Mutschler E
Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(2):146-52.
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1990: Feifel R; Wagner-Röder M; Strohmann C; Tacke R; Waelbroeck M; Christophe J; Mutschler E; Lambrecht G
Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro-difenidol and acetylenic analogues.
British journal of pharmacology 1990;99(3):455-60.
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1989: Waelbroeck M; Tastenoy M; Camus J; Feifel R; Mutschler E; Strohmann C; Tacke R; Lambrecht G; Christophe J
Stereoselectivity of the interaction of muscarinic antagonists with their receptors.
Trends in pharmacological sciences 1989;Suppl():65-9.
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1989: Lambrecht G; Feifel R; Moser U; Wagner-Röder M; Choo L K; Camus J; Tastenoy M; Waelbroeck M; Strohmann C; Tacke R
Pharmacology of hexahydro-difenidol, hexahydro-sila-difenidol and related selective muscarinic antagonists.
Trends in pharmacological sciences 1989;Suppl():60-4.
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1989: Eltze M; Lambrecht G; Mutschler E
Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes.
European journal of pharmacology 1989;173(2-3):219-22.
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1989: Eltze M; Boer R; Mutschler E; Lambrecht G
Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors.
European journal of pharmacology 1989;170(3):225-34.
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1989: Waelbroeck M; Tastenoy M; Camus J; Christophe J; Strohmann C; Linoh H; Zilch H; Tacke R; Mutschler E; Lambrecht G
Binding and functional properties of antimuscarinics of the hexocyclium/sila-hexocyclium and hexahydro-diphenidol/hexahydro-sila-diphenidol type to muscarinic receptor subtypes.
British journal of pharmacology 1989;98(1):197-205.
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1989: Lambrecht G; Feifel R; Wagner-Röder M; Strohmann C; Zilch H; Tacke R; Waelbroeck M; Christophe J; Boddeke H; Mutschler E
Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes.
European journal of pharmacology 1989;168(1):71-80.
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1989: Wolf-Pflugmann M; Lambrecht G; Wess J; Mutschler E
Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester.
Arzneimittel-Forschung 1989;39(5):539-44.
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1989: Moser U; Lambrecht G; Wagner M; Wess J; Mutschler E
Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes.
British journal of pharmacology 1989;96(2):319-24.
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1989: Lambrecht G; Feifel R; Mutschler E
Stereoselectivity at muscarinic receptor subtypes: observations with the enantiomers of phenglutarimide.
Chirality 1989;1(2):170-3.
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1988: Eltz M; Gmelin G; Wess J; Strohmann C; Tacke R; Mutschler E; Lambrecht G
Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type.
European journal of pharmacology 1988;158(3):233-42.
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1988: Lambrecht G; Feifel R; Moser U; Aasen A J; Waelbroeck M; Christophe J; Mutschler E
Stereoselectivity of the enantiomers of trihexyphenidyl and its methiodide at muscarinic receptor subtypes.
European journal of pharmacology 1988;155(1-2):167-70.
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1988: Wess J; Angeli P; Melchiorre C; Moser U; Mutschler E; Lambrecht G
Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(3):246-9.
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1988: Lambrecht G; Feifel R; Forth B; Strohmann C; Tacke R; Mutschler E
p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist.
European journal of pharmacology 1988;152(1-2):193-4.
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1988: Lambrecht G; Gmelin G; Rafeiner K; Strohmann C; Tacke R; Mutschler E
o-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist.
European journal of pharmacology 1988;151(1):155-6.
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1987: Wess J; Lambrecht G; Mutschler E; Melchiorre C; Angeli P
Selective blockade in vivo of cardiac muscarinic M2 receptors by a polymethylene tetramine, BHC-9C.
European journal of pharmacology 1987;142(3):475-8.
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1987: Buhl T; Rodrigues de Miranda J F; Beld A J; Lambrecht G; Mutschler E
Binding of the S(+)- and R(-)-enantiomers of bethanechol to muscarinic receptors in jejunal smooth muscle, nasal mucosa, atrial and ventricular myocardium of the rat.
European journal of pharmacology 1987;140(2):221-6.
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