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Diether Lambrechts

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Els Wauters; Diether Lambrechts; Gilian Peuteman; Frans Van de Werf; Ann Belmans; Andrzej Budaj; Ian Buysschaert; Kathryn F Carruthers; Donald R Dunbar; Keith A A Fox
Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the GRACE Genetics Study.
Diether Lambrechts; Heinz-Josef Lenz; Peter Carmeliet; Sanne de Haas; Stefan J Scherer
Markers of response for the antiangiogenic agent bevacizumab.
Diego A Garcia-Dios; Diether Lambrechts; Janusz Marcickiewicz; Philippe Moerman; Helga B Salvesen; Amanda B Spurdle; Johan Van Robays; Ingrid Vandenput; Ignace Vergote; Penelope M Webb; An Capoen; Bart Claes; Lieve Coenegrachts; Kaltin Ferguson; Lars A Akslen; Frederic Amant
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.

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2013: Els Wauters; Diether Lambrechts; Gilian Peuteman; Frans Van de Werf; Ann Belmans; Andrzej Budaj; Ian Buysschaert; Kathryn F Carruthers; Donald R Dunbar; Keith A A Fox
Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the GRACE Genetics Study.
European heart journal 2013;34(13):993-1001.
2013: Diether Lambrechts; Heinz-Josef Lenz; Peter Carmeliet; Sanne de Haas; Stefan J Scherer
Markers of response for the antiangiogenic agent bevacizumab.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(9):1219-30.
2013: Diego A Garcia-Dios; Diether Lambrechts; Janusz Marcickiewicz; Philippe Moerman; Helga B Salvesen; Amanda B Spurdle; Johan Van Robays; Ingrid Vandenput; Ignace Vergote; Penelope M Webb; An Capoen; Bart Claes; Lieve Coenegrachts; Kaltin Ferguson; Lars A Akslen; Frederic Amant
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
Gynecologic oncology 2013;128(2):327-34.
2013: Roel Quintens; Johannes Anthonius Romijn; Anica Schraenen; Peter Carmeliet; Veronica Costa; Katrien De Bock; Geoffroy De Faudeur; Mikaela Granvik; Diether Lambrechts; Stefan Lehnert; Katleen Lemaire; Henri Roger Lijnen; Pradeep Puthenveetil Abraham Mammen; Luca Scorrano; John Michael Shelton; Sarvjeet Singh; Lieven Thorrez; Leentje Van Lommel; Pieter Van Noten; Peter J Voshol; Irene Olga Cornelia Maria Vroegrijk; Frans Schuit
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.
PloS one 2013;8(2):e56719.
2012: An Verheyen; Peter Carmeliet; Anneleen Daniels; Joke Dhondt; Theo Meert; Rony Nuydens; Eve Peeraer; Isabel Pintelon; Koen Poesen; Jean-Pierre Timmermans; Diether Lambrechts
Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.
Brain : a journal of neurology 2012;135(Pt 9):2629-41.
2012: Sigrid Hatse; Carsten Kriebitzsch; Annouschka Laenen; Diether Lambrechts; Patrick Neven; Robert Paridaens; Gilian Peuteman; Ann Smeets; Thijs Vandorpe; Lieve Verlinden; Annemieke Verstuyf; Roger Bouillon; Olivier Brouckaert; Barbara Brouwers; Marie-Rose Christiaens; Anne-Sophie Dieudonné; Hans Wildiers
Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency.
Carcinogenesis 2012;33(7):1319-26.
2012: Diether Lambrechts; Massimiliano Mazzone; Joke Reumers; Stefan J Scherer; Sabine Tejpar; Peter Carmeliet; Bart Claes; Sanne de Haas; Paul Delmar; Roland Devlieger; Chris Verslype; Hans Wildiers; Betül T Yesilyurt; Eric Van Cutsem
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials.
The lancet oncology 2012;13(7):724-33.
2012: Litsa Nikitidou; Diether Lambrechts; Peter Carmeliet; Joke Dhondt; Kanter-Schlifke Irene; Merab Kokaia
VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures.
PloS one 2012;7(7):e40535.
2012: Benedetta Izzi; Valery Labarque; Diether Lambrechts; Eric Legius; Chantal Thys; Annick Van den Bruel; Chris Van Geet; Christine Wittevrongel; Francis de Zegher; Koen Devriendt; Marc D'Hooghe; I Francois; Kathleen Freson
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
PloS one 2012;7(6):e38579.
2011: E Wauters; D Smeets; J Vansteenkiste; Johny Verschakelen; J Coolen; P De Leyn; Marc Decramer; W Janssens; Diether Lambrechts
The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;38(4):924-31.
2011: Ann Smeets; C Sotiriou; P Van Hummelen; Isabelle Vanden Bempt; T Vandorpe; Hans Wildiers; B Claes; Anneleen Daemen; Bart De Moor; R Drijkoningen; Olivier Gevaert; Diether Lambrechts; Patrick Neven; Robert Paridaens; Marie-Rose Christiaens
Prediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs.
Breast cancer research and treatment 2011;129(3):767-76.
2011: An Windelinckx; Barbara Vincent; Robert Francois Vlietinck; Cisca Wijmenga; Jeroen Aerssens; Gaston Beunen; Gunther De Mars; Wim Huygens; Diether Lambrechts; Maarten W Peeters; Martine Thomis
Identification and prioritization of NUAK1 and PPP1CC as positional candidate loci for skeletal muscle strength phenotypes.
Physiological genomics 2011;43(17):981-92.
2011: Timothy S Maughan; Angela M Meade; Jenna K Mitchell; Matthew T Seymour; Christopher G Smith; Richard H Wilson; Richard A Adams; John Bridgewater; Jeremy P Cheadle; Bart Claes; David Fisher; Rebecca Harris; Shelley Idziaszczyk; Michelle D James; Bharat Jasani; Richard S. Kaplan; Edward Kay; M John Kennedy; Sarah L Kenny; Diether Lambrechts; Ayman Madi
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.
Lancet 2011;377(9783):2103-14.
2011: An Windelinckx; Gunther De Mars; Wim Huygens; Maarten W Peeters; Barbara Vincent; Cisca Wijmenga; Diether Lambrechts; Christophe Delecluse; Stephen M Roth; E Jeffrey Metter; Luigi Ferrucci; Jeroen Aerssens; Robert Francois Vlietinck; Gaston Beunen; Martine Thomis
Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene.
European journal of human genetics : EJHG 2011;19(2):208-15.
2010: Benedetta Izzi; Brigitte Decallonne; Koen Devriendt; Roger Bouillon; Dirk Vanderschueren; Elena Levtchenko; Francis de Zegher; Annick Van den Bruel; Diether Lambrechts; Chris Van Geet; Kathleen Freson
A new approach to imprinting mutation detection in GNAS by Sequenom EpiTYPER system.
Clinica chimica acta; international journal of clinical chemistry 2010;411(23-24):2033-9.
2010: Thomas Philips; Louis De Muynck; Hoai Nguyen Thi Thu; Bea Weynants; Peter Vanacker; Joke Dhondt; Kristel Sleegers; Helenius J Schelhaas; Marcel Verbeek; Rik Vandenberghe; Raf Sciot; Christine Van Broeckhoven; Diether Lambrechts; Fred Van Leuven; Ludo Van Den Bosch; Wim Robberecht; Philip Van Damme
Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Journal of neuropathology and experimental neurology 2010;69(12):1191-200.
2010: Erik Storkebaum; Carmen Ruiz de Almodovar; Merlijn Meens; Serena Zacchigna; Massimiliano Mazzone; Greet Vanhoutte; Stefan Vinckier; Katarzyna Miskiewicz; Koen Poesen; Diether Lambrechts; Ger M J Janssen; Gregorio E Fazzi; Patrik Verstreken; Jody Haigh; Paul M Schiffers; Hermann Rohrer; Annemie Van der Linden; Jo De Mey; Peter Carmeliet
Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.
Circulation 2010;122(3):273-81.
2010: Wim Janssens; Hilde Nuytten; Lieven J Dupont; Johan Van Eldere; Severine Vermeire; Diether Lambrechts; Kristiaan Nackaerts; Marc Decramer; Jean-Jacques Cassiman; Harry Cuppens
Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2010;182(2):163-9.
2010: Ian Buysschaert; Kathryn F Carruthers; Donald R Dunbar; Gilian Peuteman; Ernst Rietzschel; Ann Belmans; Ann Hedley; Tim De Meyer; Andrzej Budaj; Frans Van de Werf; Diether Lambrechts; Keith A A Fox
A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study.
European heart journal 2010;31(9):1132-41.
2010: Diether Lambrechts; Ian Buysschaert; Pieter Zanen; Johan Coolen; Natacha Lays; Harry Cuppens; Harry J M Groen; Walter Dewever; Rob J van Klaveren; Johny Verschakelen; Cisca Wijmenga; Dirkje S Postma; Marc Decramer; Wim Janssens
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema.
American journal of respiratory and critical care medicine 2010;181(5):486-93.
2009: Diether Lambrechts; K Poesen; R Fernández-Santiago; A Al-Chalabi; R Del Bo; P W J Van Vught; S Khan; S L Marklund; A Brockington; I van Marion; J Anneser; C Shaw; A C Ludolph; N P Leigh; G P Comi; T Gasser; P J Shaw; K E Morrison; P M Andersen; L H Van den Berg; V Thijs; T Siddique; Wim Robberecht; Peter Carmeliet
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype.
Journal of medical genetics 2009;46(12):840-6.
2009: Mieke Delvaeye; Marina Noris; Astrid De Vriese; Charles T Esmon; Naomi L Esmon; Gary Ferrell; Jurgen Del-Favero; Stephane Plaisance; Bart Claes; Diether Lambrechts; Carla Zoja; Giuseppe Remuzzi; Edward M Conway
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
The New England journal of medicine 2009;361(4):345-57.
2008: Koen Poesen; Diether Lambrechts; Philip Van Damme; Joke Dhondt; Florian Bender; Nicolas Frank; Elke Bogaert; Bart Claes; Line Heylen; An Verheyen; Katrien Raes; Marc Tjwa; Ulf Eriksson; Masabumi Shibuya; Rony Nuydens; Ludo Van Den Bosch; Theo F Meert; Rudi D'Hooge; Michael Sendtner; Wim Robberecht; Peter Carmeliet
Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(42):10451-9.
2008: Annelii Ny; Marta Koch; Wouter Vandevelde; Martin Schneider; Christian Fischer; Antonio Diez-juan; Elke Neven; Ilse Geudens; Sunit Maity; Lieve Moons; Stephane Plaisance; Diether Lambrechts; Peter Carmeliet; Mieke Dewerchin
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.
Blood 2008;112(5):1740-9.
2008: Philip Van Damme; Annelies Van Hoecke; Diether Lambrechts; Peter Vanacker; Elke Bogaert; John van Swieten; Peter Carmeliet; Ludo Van Den Bosch; Wim Robberecht
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
The Journal of cell biology 2008;181(1):37-41.
2008: Serena Zacchigna; Diether Lambrechts; Peter Carmeliet
Neurovascular signalling defects in neurodegeneration.
Nature reviews. Neuroscience 2008;9(3):169-81.
2007: Maarten Dewil; Diether Lambrechts; R Sciot; P J Shaw; Paul Geoffrey Ince; Wim Robberecht; Ludo Van Den Bosch
Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology 2007;33(5):499-509.
2007: Diether Lambrechts; Wim Robberecht; Peter Carmeliet
Heterogeneity in motoneuron disease.
Trends in neurosciences 2007;30(10):536-44.
2006: Diether Lambrechts; Peter Carmeliet
VEGF at the neurovascular interface: therapeutic implications for motor neuron disease.
Biochimica et biophysica acta 2006;1762(11-12):1109-21.
2006: Diether Lambrechts; Peggy Lafuste; Peter Carmeliet; Edward M Conway
Another angiogenic gene linked to amyotrophic lateral sclerosis.
Trends in molecular medicine 2006;12(8):345-7.
2006: Stein Aerts; Diether Lambrechts; Sunit Maity; Peter Van Loo; Bert Coessens; Frank De Smet; Léon-Charles Tranchevent; Bart De Moor; Peter Marynen; Bassem A Hassan; Peter Carmeliet; Yves Moreau
Gene prioritization through genomic data fusion.
Nature biotechnology 2006;24(5):537-44.
2005: Annelii Ny; Marta Koch; Martin Schneider; Elke Neven; Ricky T Tong; Sunit Maity; Christian Fischer; Stephane Plaisance; Diether Lambrechts; Christophe Héligon; Sven Terclavers; Malgorzata Ciesiolka; Roland Kälin; Wing Yan Man; Irena Senn; Sabine Wyns; Florea Lupu; André Brändli; Kris Vleminckx; Désiré Collen; Mieke Dewerchin; Edward M Conway; Lieve Moons; Rakesh K Jain; Peter Carmeliet
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nature medicine 2005;11(9):998-1004.
2005: Erik Storkebaum; Diether Lambrechts; Mieke Dewerchin; Maria-Paz Moreno-Murciano; Saskia Appelmans; Hideyasu Oh; Philip Van Damme; Bart Rutten; Wing Yan Man; Maria De Mol; Sabine Wyns; David Manka; Kristel Vermeulen; Ludo Van Den Bosch; Nico Mertens; Christoph Schmitz; Wim Robberecht; Edward M Conway; Désiré Collen; Lieve Moons; Peter Carmeliet
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Nature neuroscience 2005;8(1):85-92.
2004: Diether Lambrechts; Peter Carmeliet
Sculpting heart valves with NFATc and VEGF.
Cell 2004;118(5):532-4.
2004: Erik Storkebaum; Diether Lambrechts; Peter Carmeliet
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(9):943-54.
2004: Diether Lambrechts; Erik Storkebaum; Peter Carmeliet
VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?
Trends in molecular medicine 2004;10(6):275-82.
2004: Diether Lambrechts; Peter Carmeliet
Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF.
Current topics in developmental biology 2004;62():189-224.
2003: Monica Autiero; Johannes Waltenberger; David Communi; Andrea Kranz; Lieve Moons; Diether Lambrechts; Jens Kroll; Stephane Plaisance; Maria De Mol; Françoise Bono; Stefanie Kliche; Guido Fellbrich; Kurt Ballmer-Hofer; Domenico Maglione; Ulrike Mayr-Beyrle; Mieke Dewerchin; Saskia Dombrowski; Danica Stanimirovic; Paul van Hummelen; Christoph Dehio; Daniel J Hicklin; Graziella Persico; Jean-Marc Herbert; David Communi; Masabumi Shibuya; Désiré Collen; Edward M Conway; Peter Carmeliet
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nature medicine 2003;9(7):936-43.