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Dudley Lamming

Research Profile

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Physiology

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Publications

TOP 3
Basil P Hubbard; Yong Jiang; Dudley W Lamming; Jessica E Lee; Jun Li; Alvin J Y Ling; Shaday Michan; Joel Moss; Pui Yee Ng; Bradley L Pentelute; Robert B Perni; Thomas V Riera; Anabela P Rolo; Eli R Schuman; Sean M Armour; Charles A Blum; April W Case; Thomas Considine; Han Dai; Jeremy S Disch; Sook Yen E; James L Ellis; Ana P Gomes; Yoshitomo Hamuro; Konrad T Howitz; Linda A Stevens; Sharon M Sweitzer; George P Vlasuk; Huizhen Zhao; David A Sinclair
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Dudley W Lamming; David M Sabatini; Lan Ye; Joseph A Baur
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
Ömer H Yilmaz; V Onur Yilmaz; Lawrence R Zukerberg; Martin Selig; Shomit Sengupta; Khristian E Bauer-Rowe; Atul K Bhan; kivanc birsoy; Vikram Deshpande; Abdulmetin Dursun; Yetis Gültekin; Pekka Katajisto; Dudley W Lamming; Mari Mino-Kenudson; G Petur Nielsen; David M Sabatini
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

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All Publications

2013: Basil P Hubbard; Yong Jiang; Dudley W Lamming; Jessica E Lee; Jun Li; Alvin J Y Ling; Shaday Michan; Joel Moss; Pui Yee Ng; Bradley L Pentelute; Robert B Perni; Thomas V Riera; Anabela P Rolo; Eli R Schuman; Sean M Armour; Charles A Blum; April W Case; Thomas Considine; Han Dai; Jeremy S Disch; Sook Yen E; James L Ellis; Ana P Gomes; Yoshitomo Hamuro; Konrad T Howitz; Linda A Stevens; Sharon M Sweitzer; George P Vlasuk; Huizhen Zhao; David A Sinclair
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Science (New York, N.Y.) 2013;339(6124):1216-9.
2013: Dudley W Lamming; David M Sabatini; Lan Ye; Joseph A Baur
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
The Journal of clinical investigation 2013;123(3):980-9.
2012: Ömer H Yilmaz; V Onur Yilmaz; Lawrence R Zukerberg; Martin Selig; Shomit Sengupta; Khristian E Bauer-Rowe; Atul K Bhan; kivanc birsoy; Vikram Deshpande; Abdulmetin Dursun; Yetis Gültekin; Pekka Katajisto; Dudley W Lamming; Mari Mino-Kenudson; G Petur Nielsen; David M Sabatini
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Nature 2012;486(7404):490-5.
2012: Stacey Robida-Stubbs; David M Sabatini; Kira Glover-Cutter; Dudley W Lamming; Masaki Mizunuma; Sri Devi Narasimhan; Elke Neumann-Haefelin; T Keith Blackwell
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Cell metabolism 2012;15(5):713-24.
2012: Dudley W Lamming; Arlan G Richardson; David M Sabatini; Maki Saitoh; Adam B Salmon; Deanna M Stevens; Lan Ye; James G Davis; Marcus D Goncalves; David A Guertin; Pekka Katajisto; Rexford S Ahima; Joseph A Baur
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Science (New York, N.Y.) 2012;335(6076):1638-43.
2012: Lan Ye; Dudley W Lamming; David M Sabatini; Behzad Varamini; Joseph A Baur
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.
Frontiers in genetics 2012;3():177.
2011: Dudley W Lamming; David M Sabatini
A radical role for TOR in longevity.
Cell metabolism 2011;13(6):617-8.
2007: Oliver Medvedik; Dudley W Lamming; Keyman D Kim; David A Sinclair
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
PLoS biology 2007;5(10):e261.
2007: Hongying Yang; Tianle Yang; Joseph A Baur; Evelyn Perez; Takashi Matsui; Juan J Carmona; Dudley W Lamming; Nadja C Souza-Pinto; Vilhelm A Bohr; Anthony Rosenzweig; Rafael de Cabo; Anthony A Sauve; David A Sinclair
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Cell 2007;130(6):1095-107.
2006: Michael Yu; Dudley W Lamming; Julian A Eskin; David A Sinclair; Pamela A Silver
The role of protein arginine methylation in the formation of silent chromatin.
Genes & development 2006;20(23):3249-54.
2005: Dudley W Lamming; Magda Latorre-Esteves; Oliver Medvedik; Stacy N Wong; Felicia A Tsang; Chen Wang; Su-Ju Lin; David A Sinclair
HST2 mediates SIR2-independent life-span extension by calorie restriction.
Science (New York, N.Y.) 2005;309(5742):1861-4.
2004: Dudley W Lamming; Jason G Wood; David A Sinclair
Small molecules that regulate lifespan: evidence for xenohormesis.
Molecular microbiology 2004;53(4):1003-9.
2003: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Nature 2003;425(6954):191-6.