Thomas LaMont

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Leffler Daniel A; Lamont J Thomas
A 69-year-old woman presenting to the hospital with 48 hours of abdominal pain and diarrhea.
Leffler Daniel A; Lamont J Thomas
Treatment of Clostridium difficile-associated disease.
Na Xi; Kim Ho; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.

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2009: Leffler Daniel A; Lamont J Thomas
A 69-year-old woman presenting to the hospital with 48 hours of abdominal pain and diarrhea.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(10):1046-8.
2009: Leffler Daniel A; Lamont J Thomas
Treatment of Clostridium difficile-associated disease.
Gastroenterology 2009;136(6):1899-912.
2008: Na Xi; Kim Ho; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.
Infection and immunity 2008;76(7):2862-71.
2007: Kim Ho; Rhee Sang Hoon; Pothoulakis Charalabos; Lamont J Thomas
Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand.
Gastroenterology 2007;133(3):875-86.
2006: Maroo Seema; Lamont J Thomas
Recurrent clostridium difficile.
Gastroenterology 2006;130(4):1311-6.
2005: Kim Ho; Kokkotou Efi; Na Xi; Rhee Sang Hoon; Moyer Mary P; Pothoulakis Charalabos; Lamont J Thomas
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.
Gastroenterology 2005;129(6):1875-88.
2005: Kim Ho; Rhee Sang Hoon; Kokkotou Efi; Na Xi; Savidge Tor; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
The Journal of biological chemistry 2005;280(22):21237-45.
2005: Na Xi; Zhao Dezheng; Koon Hon Wai; Kim Ho; Husmark Johanna; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes.
Gastroenterology 2005;128(4):1002-11.
2003: Morrin Martina M; LaMont J Thomas
Screening virtual colonoscopy--ready for prime time?
The New England journal of medicine 2003;349(23):2261-4.
2003: Khatri Ismat A; Bhaskar K Ramakrishnan; Lamont J Thomas; Sajjan S Umadevi; Ho Catherine K Y; Forstner Janet
Effect of chondroitinase ABC on purulent sputum from cystic fibrosis and other patients.
Pediatric research 2003;53(4):619-27.
2003: Li Youzhi; Sun Xiangao; LaMont J Thomas; Pardee Arthur B; Li Chiang J
Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2674-8.
2002: He Dan; Sougioultzis Stavros; Hagen Susan; Liu Jennifer; Keates Sarah; Keates Andrew C; Pothoulakis Charalabos; Lamont J Thomas
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation.
Gastroenterology 2002;122(4):1048-57.
2002: Farrell Richard J; LaMont J Thomas
Microbial factors in inflammatory bowel disease.
Gastroenterology clinics of North America 2002;31(1):41-62.
2002: Chen Ming L; Pothoulakis Charalabos; LaMont J Thomas
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A.
The Journal of biological chemistry 2002;277(6):4247-54.
2002: Lamont J Thomas
Theodore E. Woodward Award. How bacterial enterotoxins work: insights from in vivo studies.
Transactions of the American Clinical and Climatological Association 2002;113():167-80; discussion 180-1.
2001: Qamar A; Aboudola S; Warny M; Michetti P; Pothoulakis C; LaMont J T; Kelly C P
Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice.
Infection and immunity 2001;69(4):2762-5.
2001: Sheth S G; LaMont J T
Gastrointestinal problems in the chronically critically ill patient.
Clinics in chest medicine 2001;22(1):135-47.
2001: Pothoulakis C; Lamont J T
Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(2):G178-83.
2000: Farrell R J; Alsahli M; LaMont J T
Is successful triage of patients with upper-gastrointestinal bleeding possible without endoscopy?
Lancet 2000;356(9238):1289-90.
2000: He D; Hagen S J; Pothoulakis C; Chen M; Medina N D; Warny M; LaMont J T
Clostridium difficile toxin A causes early damage to mitochondria in cultured cells.
Gastroenterology 2000;119(1):139-50.
2000: Warny M; Keates A C; Keates S; Castagliuolo I; Zacks J K; Aboudola S; Qamar A; Pothoulakis C; LaMont J T; Kelly C P
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis.
The Journal of clinical investigation 2000;105(8):1147-56.
2000: Banerjee S; LaMont J T
Treatment of gastrointestinal infections.
Gastroenterology 2000;118(2 Suppl 1):S48-67.
2000: Farrell R J; LaMont J T
Pathogenesis and clinical manifestations of Clostridium difficile diarrhea and colitis.
Current topics in microbiology and immunology 2000;250():109-25.
1999: Castagliuolo I; LaMont J T
Pathophysiology, diagnosis and treatment of Clostridium difficile infection.
The Keio journal of medicine 1999;48(4):169-74.
1999: Turner B S; Bhaskar K R; Hadzopoulou-Cladaras M; LaMont J T
Cysteine-rich regions of pig gastric mucin contain von willebrand factor and cystine knot domains at the carboxyl terminal(1).
Biochimica et biophysica acta 1999;1447(1):77-92.
1999: Morrin M M; Farrell R J; Kruskal J B; LaMont J T
Virtual colonoscopy: a kinder, gentler colorectal cancer screening test?
Lancet 1999;354(9184):1048-9.
1999: Riegler M; Lotz M; Sears C; Pothoulakis C; Castagliuolo I; Wang C C; Sedivy R; Sogukoglu T; Cosentini E; Bischof G; Feil W; Teleky B; Hamilton G; LaMont J T; Wenzl E
Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro.
Gut 1999;44(4):504-10.
1999: Cao X; Bansil R; Bhaskar K R; Turner B S; LaMont J T; Niu N; Afdhal N H
pH-dependent conformational change of gastric mucin leads to sol-gel transition.
Biophysical journal 1999;76(3):1250-8.
1999: Qiu B; Pothoulakis C; Castagliuolo I; Nikulasson S; LaMont J T
Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced enteritis in rats.
The American journal of physiology 1999;276(2 Pt 1):G485-90.
1999: Warny M; Fatimi A; Bostwick E F; Laine D C; Lebel F; LaMont J T; Pothoulakis C; Kelly C P
Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine.
Gut 1999;44(2):212-7.
1999: Castagliuolo I; Riegler M F; Valenick L; LaMont J T; Pothoulakis C
Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa.
Infection and immunity 1999;67(1):302-7.
1998: Farrell R J; LaMont J T
Rational approach to iron-deficiency anaemia in premenopausal women.
Lancet 1998;352(9145):1953-4.
1998: Castagliuolo I; Keates A C; Wang C C; Pasha A; Valenick L; Kelly C P; Nikulasson S T; LaMont J T; Pothoulakis C
Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6039-45.
1998: Sheth S G; LaMont J T
Toxic megacolon.
Lancet 1998;351(9101):509-13.
1998: Bhaskar K R; Turner B S; Grubman S A; Jefferson D M; LaMont J T
Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (delta-f508) cystic fibrosis transmembrane conductance regulator.
Hepatology (Baltimore, Md.) 1998;27(1):7-14.
1998: Kelly C P; LaMont J T
Clostridium difficile infection.
Annual review of medicine 1998;49():375-90.
1997: Linevsky J K; Pothoulakis C; Keates S; Warny M; Keates A C; Lamont J T; Kelly C P
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes.
The American journal of physiology 1997;273(6 Pt 1):G1333-40.
1997: Riegler M; Sedivy R; Sogukoglu T; Castagliuolo I; Pothoulakis C; Cosentini E; Bischof G; Hamilton G; Teleky B; Feil W; Lamont J T; Wenzl E
Epidermal growth factor attenuates Clostridium difficile toxin A- and B-induced damage of human colonic mucosa.
The American journal of physiology 1997;273(5 Pt 1):G1014-22.
1997: Salcedo J; Keates S; Pothoulakis C; Warny M; Castagliuolo I; LaMont J T; Kelly C P
Intravenous immunoglobulin therapy for severe Clostridium difficile colitis.
Gut 1997;41(3):366-70.
1997: Castagliuolo I; Kelly C P; Qiu B S; Nikulasson S T; LaMont J T; Pothoulakis C
IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum.
The American journal of physiology 1997;273(2 Pt 1):G333-41.
1997: Grübel P; Bhaskar K R; Cave D R; Garik P; Stanley H E; Lamont J T
Interaction of an aluminum-magnesium containing antacid and gastric mucus: possible contribution to the cytoprotective function of antacids.
Alimentary pharmacology & therapeutics 1997;11(1):139-45.
1997: Kelly C P; Chetham S; Keates S; Bostwick E F; Roush A M; Castagliuolo I; LaMont J T; Pothoulakis C
Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract.
Antimicrobial agents and chemotherapy 1997;41(2):236-41.
1996: Castagliuolo I; LaMont J T; Nikulasson S T; Pothoulakis C
Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum.
Infection and immunity 1996;64(12):5225-32.
1996: Castagliuolo I; Lamont J T; Qiu B; Fleming S M; Bhaskar K R; Nikulasson S T; Kornetsky C; Pothoulakis C
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells.
The American journal of physiology 1996;271(5 Pt 1):G884-92.
1996: Pothoulakis C; Gilbert R J; Cladaras C; Castagliuolo I; Semenza G; Hitti Y; Montcrief J S; Linevsky J; Kelly C P; Nikulasson S; Desai H P; Wilkins T D; LaMont J T
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.
The Journal of clinical investigation 1996;98(3):641-9.
1996: Castagliuolo I; LaMont J T; Qiu B; Nikulasson S T; Pothoulakis C
A receptor decoy inhibits the enterotoxic effects of Clostridium difficile toxin A in rat ileum.
Gastroenterology 1996;111(2):433-8.
1996: Qiu B; Pothoulakis C; Castagliuolo I; Nikulasson Z; LaMont J T
Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin.
Gastroenterology 1996;111(2):409-18.
1996: Pothoulakis C; Galili U; Castagliuolo I; Kelly C P; Nikulasson S; Dudeja P K; Brasitus T A; LaMont J T
A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon.
Gastroenterology 1996;110(6):1704-12.
1996: Larson R G; Turner B S; Bhaskar K R; LaMont J T; Rothschild M F
Rapid communication: BamHI restriction fragment length polymorphism detected with a pig gastric mucin (MUC5AC) probe.
Journal of animal science 1996;74(6):1443.
1996: Kelly C P; Pothoulakis C; Vavva F; Castagliuolo I; Bostwick E F; O'Keane J C; Keates S; LaMont J T
Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins.
Antimicrobial agents and chemotherapy 1996;40(2):373-9.
1995: Turner B S; Bhaskar K R; Hadzopoulou-Cladaras M; Specian R D; LaMont J T
Isolation and characterization of cDNA clones encoding pig gastric mucin.
The Biochemical journal 1995;308 ( Pt 1)():89-96.
1995: Riegler M; Sedivy R; Pothoulakis C; Hamilton G; Zacherl J; Bischof G; Cosentini E; Feil W; Schiessel R; LaMont J T
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.
The Journal of clinical investigation 1995;95(5):2004-11.
1995: Gilbert R J; Pothoulakis C; LaMont J T; Yakubovich M
Clostridium difficile toxin B activates calcium influx required for actin disassembly during cytotoxicity.
The American journal of physiology 1995;268(3 Pt 1):G487-95.
1995: Bansil R; Stanley E; LaMont J T
Mucin biophysics.
Annual review of physiology 1995;57():635-57.
1994: Mitty R D; Lamont J T
Clostridium difficile colitis: epidemiology, pathophysiology, and treatment.
The Mount Sinai journal of medicine, New York 1994;61(4):329-35.
1994: Castagliuolo I; LaMont J T; Letourneau R; Kelly C; O'Keane J C; Jaffer A; Theoharides T C; Pothoulakis C
Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum.
Gastroenterology 1994;107(3):657-65.
1994: Mitty R D; LaMont J T
Clostridium difficile diarrhea: pathogenesis, epidemiology, and treatment.
The Gastroenterologist 1994;2(1):61-9.
1994: Kelly C P; Becker S; Linevsky J K; Joshi M A; O'Keane J C; Dickey B F; LaMont J T; Pothoulakis C
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.
The Journal of clinical investigation 1994;93(3):1257-65.
1994: Pothoulakis C; Castagliuolo I; LaMont J T; Jaffer A; O'Keane J C; Snider R M; Leeman S E
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):947-51.
1994: Kelly C P; Pothoulakis C; LaMont J T
Clostridium difficile colitis.
The New England journal of medicine 1994;330(4):257-62.
1993: Pothoulakis C; LaMont J T
Clostridium difficile colitis and diarrhea.
Gastroenterology clinics of North America 1993;22(3):623-37.
1993: Pothoulakis C; Karmeli F; Kelly C P; Eliakim R; Joshi M A; O'Keane C J; Castagliuolo I; LaMont J T; Rachmilewitz D
Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum.
Gastroenterology 1993;105(3):701-7.
1993: Afdhal N H; Gong D; Niu N; Turner B; LaMont J T; Offner G D
Cholesterol cholelithiasis in the prairie dog: role of mucin and nonmucin glycoproteins.
Hepatology (Baltimore, Md.) 1993;17(4):693-700.
1993: Pothoulakis C; Kelly C P; Joshi M A; Gao N; O'Keane C J; Castagliuolo I; Lamont J T
Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum.
Gastroenterology 1993;104(4):1108-15.
1992: Bhaskar K R; Garik P; Turner B S; Bradley J D; Bansil R; Stanley H E; LaMont J T
Viscous fingering of HCl through gastric mucin.
Nature 1992;360(6403):458-61.
1992: Kelly C P; O'Keane J C; Orellana J; Schroy P C; Yang S; LaMont J T; Brady H R
Human colon cancer cells express ICAM-1 in vivo and support LFA-1-dependent lymphocyte adhesion in vitro.
The American journal of physiology 1992;263(6 Pt 1):G864-70.
1992: Eglow R; Pothoulakis C; Itzkowitz S; Israel E J; O'Keane C J; Gong D; Gao N; Xu Y L; Walker W A; LaMont J T
Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor.
The Journal of clinical investigation 1992;90(3):822-9.
1992: Kelly C P; Pothoulakis C; Orellana J; LaMont J T
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding.
Gastroenterology 1992;102(1):35-40.
1991: Bhaskar K R; Gong D H; Bansil R; Pajevic S; Hamilton J A; Turner B S; LaMont J T
Profound increase in viscosity and aggregation of pig gastric mucin at low pH.
The American journal of physiology 1991;261(5 Pt 1):G827-32.
1991: Pothoulakis C; LaMont J T; Eglow R; Gao N; Rubins J B; Theoharides T C; Dickey B F
Characterization of rabbit ileal receptors for Clostridium difficile toxin A. Evidence for a receptor-coupled G protein.
The Journal of clinical investigation 1991;88(1):119-25.
1991: O'Leary D P; Murray F E; Turner B S; LaMont J T
Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro.
Hepatology (Baltimore, Md.) 1991;13(5):957-61.
1991: Leung D Y; Kelly C P; Boguniewicz M; Pothoulakis C; LaMont J T; Flores A
Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin.
The Journal of pediatrics 1991;118(4 ( Pt 1)):633-7.
1990: Gong D H; Turner B; Bhaskar K R; Lamont J T
Lipid binding to gastric mucin: protective effect against oxygen radicals.
The American journal of physiology 1990;259(4 Pt 1):G681-6.
1990: Miller P D; Pothoulakis C; Baeker T R; LaMont J T; Rothstein T L
Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore.
Cellular immunology 1990;126(1):155-63.
1989: Triadafilopoulos G; Pothoulakis C; Weiss R; Giampaolo C; Lamont J T
Comparative study of Clostridium difficile toxin A and cholera toxin in rabbit ileum.
Gastroenterology 1989;97(5):1186-92.
1989: Gilbert R J; Pothoulakis C; LaMont J T
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. II. Toxin B.
The American journal of physiology 1989;256(4 Pt 1):G767-72.
1989: Gilbert R J; Triadafilopoulos G; Pothoulakis C; Giampaolo C; LaMont J T
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. I. Toxin A.
The American journal of physiology 1989;256(4 Pt 1):G759-66.
1988: Pothoulakis C; Sullivan R; Melnick D A; Triadafilopoulos G; Gadenne A S; Meshulam T; LaMont J T
Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.
The Journal of clinical investigation 1988;81(6):1741-5.
1987: Hale W B; Turner B; LaMont J T
Oxygen radicals stimulate guinea pig gallbladder glycoprotein secretion in vitro.
The American journal of physiology 1987;253(5 Pt 1):G627-30.
1983: LaMont J T; Ventola A S; Trotman B W; Soloway R D
Mucin glycoprotein content of human pigment gallstones.
Hepatology (Baltimore, Md.) 1983;3(3):377-82.
1983: LaMont J T; Turner B S; Bernstein S E; Trotman B
Gallbladder glycoprotein secretion in mice with hemolytic anemia and pigment gallstones.
Hepatology (Baltimore, Md.) 1983;3(2):198-200.

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Thomas LaMont

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