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Betty Lamothe

Research Profile

Chemicals & Drugs

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Protein Structure, Tertiary

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Publications

TOP 3
Betty Lamothe; Michael D Schneider; Min Xie; YunJu Lai; Bryant G Darnay
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Betty Lamothe; Hui-Kuan Lin; Cynthia R Lockworth; Natalia Martin Orozco; Michael D Schneider; Diep Tran; Jing Wang; Min Xie; Sity Dawud; Chen Dong; Zeev Estrov; Michael Ho; Peter Hu; Lana Hur; Jared Jakacky; Yunju Lai; Carlos E Bueso-Ramos; Alejandro D Campos; Bryant G Darnay
Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.
Ching-Yuan Wu; Juan Wu; Wei-Lei Yang; Xian Zhang; Jing Wang; Alejandro D Campos; Chia-Hsin Chan; Bryant G Darnay; Yun Seong Jeong; Hong-Yo Kang; Betty Lamothe; Szu-Wei Lee; Hui-Kuan Lin
Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.

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All Publications

2013: Betty Lamothe; Michael D Schneider; Min Xie; YunJu Lai; Bryant G Darnay
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Molecular and cellular biology 2013;33(3):582-95.
2012: Betty Lamothe; Hui-Kuan Lin; Cynthia R Lockworth; Natalia Martin Orozco; Michael D Schneider; Diep Tran; Jing Wang; Min Xie; Sity Dawud; Chen Dong; Zeev Estrov; Michael Ho; Peter Hu; Lana Hur; Jared Jakacky; Yunju Lai; Carlos E Bueso-Ramos; Alejandro D Campos; Bryant G Darnay
Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.
PloS one 2012;7(12):e51228.
2011: Ching-Yuan Wu; Juan Wu; Wei-Lei Yang; Xian Zhang; Jing Wang; Alejandro D Campos; Chia-Hsin Chan; Bryant G Darnay; Yun Seong Jeong; Hong-Yo Kang; Betty Lamothe; Szu-Wei Lee; Hui-Kuan Lin
Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.
The Journal of biological chemistry 2011;286(35):30806-15.
2009: Qian Yin; Betty Lamothe; Bryant G Darnay; Hao Wu
Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry 2009;48(44):10558-67.
2009: Wei-Lei Yang; Jing Wang; Chia-Hsin Chan; Szu-Wei Lee; Alejandro D Campos; Betty Lamothe; Lana Hur; Brian Grabiner; Xin Lin; Bryant G Darnay; Hui-Kuan Lin
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Science (New York, N.Y.) 2009;325(5944):1134-8.
2009: Qian Yin; Su-Chang Lin; Betty Lamothe; Miao Lu; Yu-Chih Lo; Gregory Hura; Lixin Zheng; Rebecca L Rich; Alejandro D Campos; David G Myszka; Michael J Lenardo; Bryant G Darnay; Hao Wu
E2 interaction and dimerization in the crystal structure of TRAF6.
Nature structural & molecular biology 2009;16(6):658-66.
2008: Betty Lamothe; Alejandro D Campos; William K Webster; Ambily Gopinathan; Lana Hur; Bryant G Darnay
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
The Journal of biological chemistry 2008;283(36):24871-80.
2008: Ji Wu; Feng Meng; Ling-Yuan Kong; Zhenghong Peng; Yunming Ying; William G Bornmann; Bryant G Darnay; Betty Lamothe; Hanshi Sun; Moshe Talpaz; Nicholas J Donato
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.
Journal of the National Cancer Institute 2008;100(13):926-39.
2008: Su-Chang Lin; Jee Y Chung; Betty Lamothe; Kanagalaghatta Rajashankar; Miao Lu; Yu-Chih Lo; Amy Y Lam; Bryant G Darnay; Hao Wu
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.
Journal of molecular biology 2008;376(2):526-40.
2007: Betty Lamothe; William K Webster; Ambily Gopinathan; Arnaud Besse; Alejandro D Campos; Bryant G Darnay
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.
Biochemical and biophysical research communications 2007;359(4):1044-9.
2007: Arnaud Besse; Betty Lamothe; Alejandro D Campos; William K Webster; Upendra Maddineni; Su-Chang Lin; Hao Wu; Bryant G Darnay
TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
The Journal of biological chemistry 2007;282(6):3918-28.
2007: Betty Lamothe; Arnaud Besse; Alejandro D Campos; William K Webster; Hao Wu; Bryant G Darnay
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
The Journal of biological chemistry 2007;282(6):4102-12.
2007: Bryant G Darnay; Arnaud Besse; Ann T Poblenz; Betty Lamothe; Jörg J Jacoby
TRAFs in RANK signaling.
Advances in experimental medicine and biology 2007;597():152-9.
2002: Asok Mukhopadhyay; Shishir Shishodia; Jill Suttles; Katherine C Brittingham; Betty Lamothe; Ramadevi Nimmanapalli; Kapil N Bhalla; Bharat B Aggarwal
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.
The Journal of biological chemistry 2002;277(34):30622-8.
2002: Hong Ye; Joseph R Arron; Betty Lamothe; Maurizio Cirilli; Takashi Kobayashi; Nirupama K Shevde; Deena Segal; Oki K Dzivenu; Masha Vologodskaia; Mijung Yim; Khoi Du; Sujay Singh; J Wesley Pike; Bryant G Darnay; Yongwon Choi; Hao Wu
Distinct molecular mechanism for initiating TRAF6 signalling.
Nature 2002;418(6896):443-7.
2002: Sekhar Majumdar; Betty Lamothe; Bharat B Aggarwal
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2644-51.
2002: Betty Lamothe; Bharat B Aggarwal
Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(2):269-79.