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Theodore Lampidis

Research Profile

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Haibin Xi; Jaime Merchan; Julio C Barredo; Theodore J Lampidis
Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy.
Samuel K Houston; Theodore J Lampidis; Timothy G Murray
Models and discovery strategies for new therapies of retinoblastoma.
Luis E Raez; Alejandro D Ricart; Caio M Rocha Lima; Joseph Rosenblatt; James J Schlesselman; Mark N Stein; Khaled A Tolba; E Gabriella Chiorean; Robert S Dipaola; Donald T Jung; Stewart Kroll; Metin Kurtoglu; Virginia K Langmuir; Kyriakos Papadopoulos; Theodore J Lampidis
A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.

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2013: Haibin Xi; Jaime Merchan; Julio C Barredo; Theodore J Lampidis
Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy.
Biochemical pharmacology 2013;85(10):1463-77.
2013: Samuel K Houston; Theodore J Lampidis; Timothy G Murray
Models and discovery strategies for new therapies of retinoblastoma.
Expert opinion on drug discovery 2013;8(4):383-94.
2013: Luis E Raez; Alejandro D Ricart; Caio M Rocha Lima; Joseph Rosenblatt; James J Schlesselman; Mark N Stein; Khaled A Tolba; E Gabriella Chiorean; Robert S Dipaola; Donald T Jung; Stewart Kroll; Metin Kurtoglu; Virginia K Langmuir; Kyriakos Papadopoulos; Theodore J Lampidis
A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology 2013;71(2):523-30.
2012: Howard J Leung; Samita Andreansky; Elda M Duran; Metin Kurtoglu; Theodore J Lampidis; Enrique Mesri
Activation of the unfolded protein response by 2-deoxy-D-glucose inhibits Kaposi's sarcoma-associated herpesvirus replication and gene expression.
Antimicrobial agents and chemotherapy 2012;56(11):5794-803.
2012: Joanna DeSalvo; Jianfeng Du; Jeffim N Kuznetsov; Theodore J Lampidis; Guy Leclerc; Gilles Leclerc; Julio Barredo
Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.
Molecular cancer research : MCR 2012;10(7):969-78.
2012: Medhi Wangpaichitr; Chunjing Wu; Min You; Elizabeth J Sullivan; George Theodoropoulos; Lynn Feun; M Tien Kuo; Theodore J Lampidis; Niramol Savaraj
The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells.
Molecular cancer therapeutics 2012;11(3):604-15.
2012: Yolanda Piña; Nikesh Shah; Milena Lopez-Cavalcante; Timothy G Murray; Magda Celdran; Christina Decatur; William Feuer; Eleut Hernandez; Samuel K Houston; Theodore J Lampidis
Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors.
Investigative ophthalmology & visual science 2012;53(2):996-1002.
2012: Yolanda Piña; William Scott; Timothy G Murray; Lubov Nathanson; Jennifer Clarke; Christina Decatur; Samuel K Houston; Tulay Koru-Sengul; Theodore J Lampidis
Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH(BETA)T(AG) retinal tumors.
Clinical ophthalmology (Auckland, N.Z.) 2012;6():817-30.
2011: Haibin Xi; Metin Kurtoglu; Huaping Liu; Medhi Wangpaichitr; Min You; Xiongfei Liu; Niramol Savaraj; Theodore J Lampidis
2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
Cancer chemotherapy and pharmacology 2011;67(4):899-910.
2011: Y Piña; C Decatur; Timothy G Murray; Sk Houston; D Gologorsky; M Cavalcante; L Cavalcante; Eleut Hernandez; M Celdran; William Feuer; Theodore J Lampidis
Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LH(BETA)T(AG) retinal tumors.
Clinical ophthalmology (Auckland, N.Z.) 2011;5():337-43.
2011: Samuel K Houston; Yolanda Piña; Timothy G Murray; Hinda Boutrid; Colleen Cebulla; Amy C Schefler; Wei Shi; Magda Celdran; William Feuer; Jaime Merchan; Theodore J Lampidis
Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LH(BETA)T(AG) retinoblastoma tumors.
Clinical ophthalmology (Auckland, N.Z.) 2011;5():129-37.
2010: Yolanda Piña; Samuel K Houston; Timothy G Murray; Hinda Boutrid; Magda Celdran; William Feuer; Wei Shi; Eleut Hernandez; Theodore J Lampidis
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
Investigative ophthalmology & visual science 2010;51(12):6149-56.
2010: Metin Kurtoglu; Katherine Philips; Huaping Liu; Lawrence H Boise; Theodore J Lampidis
High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors.
Cancer chemotherapy and pharmacology 2010;66(1):129-40.
2010: Jaime Merchan; Krisztina Kovács; Jaclyn W Railsback; Metin Kurtoglu; Yuqi Jing; Yolanda Piña; Ningguo Gao; Timothy G Murray; Mark A Lehrman; Theodore J Lampidis
Antiangiogenic activity of 2-deoxy-D-glucose.
PloS one 2010;5(10):e13699.
2009: Hinda Boutrid; Yolanda Piña; Colleen Cebulla; William J Feuer; Theodore J Lampidis; Maria-Elena Jockovich; Timothy G Murray
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
Investigative ophthalmology & visual science 2009;50(12):5537-43.
2009: Metin Kurtoglu; Theodore J Lampidis
From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors.
Molecular nutrition & food research 2009;53(1):68-75.
2008: Medhi Wangpaichitr; Chunjing Wu; Min You; M T Kuo; Lynn Feun; Theodore J Lampidis; Niramol Savaraj
Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins.
European journal of pharmacology 2008;591(1-3):124-7.
2008: Hinda Boutrid; Maria-Elena Jockovich; Timothy G Murray; Yolanda Piña; William J Feuer; Theodore J Lampidis; Colleen Cebulla
Targeting hypoxia, a novel treatment for advanced retinoblastoma.
Investigative ophthalmology & visual science 2008;49(7):2799-805.
2008: Medhi Wangpaichitr; Niramol Savaraj; Johnathan Maher; Metin Kurtoglu; Theodore J Lampidis
Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines.
Molecular cancer therapeutics 2008;7(6):1506-13.
2008: Subbarayan Pochi; Peng George Wang; Theodore J Lampidis; Bach Ardalan; Paul Braunschweiger
Differential expression of Glut 1 mRNA and protein levels correlates with increased sensitivity to the glyco-conjugated nitric oxide donor (2-glu-SNAP) in different tumor cell types.
Journal of chemotherapy (Florence, Italy) 2008;20(1):106-11.
2007: Metin Kurtoglu; Ningguo Gao; Jie Shang; Johnathan Maher; Mark A Lehrman; Medhi Wangpaichitr; Niramol Savaraj; Andrew N Lane; Theodore J Lampidis
Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation.
Molecular cancer therapeutics 2007;6(11):3049-58.
2007: Metin Kurtoglu; Johnathan Maher; Theodore J Lampidis
Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.
Antioxidants & redox signaling 2007;9(9):1383-90.
2007: Johnathan Maher; Medhi Wangpaichitr; Niramol Savaraj; Metin Kurtoglu; Theodore J Lampidis
Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.
Molecular cancer therapeutics 2007;6(2):732-41.
2006: Theodore J Lampidis; Metin Kurtoglu; Johnathan Maher; Huaping Liu; AWTAR KRISHAN; Valerie Sheft; Slawomir Szymanski; Izabela Fokt; Witold R Rudnicki; Krzysztof Ginalski; Bogdan Lesyng; Waldemar Priebe
Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".
Cancer chemotherapy and pharmacology 2006;58(6):725-34.
2005: Johnathan Maher; Niramol Savaraj; Waldemar Priebe; Huaping Liu; Theodore J Lampidis
Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression.
Pancreas 2005;30(2):e34-9.
2005: Niramol Savaraj; Chunjing Wu; Howard Landy; Medhi Wangpaijit; Yingjie Wei; M Tien Kuo; Carlos Robles; Alex Furst; Theodore J Lampidis; Lynn Feun
Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma.
Cancer investigation 2005;23(7):577-81.
2005: Chunjing Wu; Medhi Wangpaichitr; Lynn Feun; Marcus Tien Kuo; Carlos Robles; Theodore J Lampidis; Niramol Savaraj
Overcoming cisplatin resistance by mTOR inhibitor in lung cancer.
Molecular cancer 2005;4(1):25.
2004: Johnathan Maher; AWTAR KRISHAN; Theodore J Lampidis
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
Cancer chemotherapy and pharmacology 2004;53(2):116-22.
2004: Gregory Maschek; Niramol Savaraj; Waldemar Priebe; Paul Braunschweiger; Kara Hamilton; George F Tidmarsh; Linda R De Young; Theodore J Lampidis
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo.
Cancer research 2004;64(1):31-4.
2003: Niramol Savaraj; Chunjing Wu; Medhi Wangpaichitr; M Tien Kuo; Theodore J Lampidis; Carlos Robles; Alex Furst; Lynn Feun
Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.
International journal of oncology 2003;23(1):173-9.
2003: Yan Ping Hu; Bushra Haq; Kermit L Carraway; Niramol Savaraj; Theodore J Lampidis
Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.
Biochemical pharmacology 2003;65(9):1419-25.
2002: Huaping Liu; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).
Biochemical pharmacology 2002;64(12):1745-51.
2001: H Liu; Y P Hu; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Hypersensitization of tumor cells to glycolytic inhibitors.
Biochemistry 2001;40(18):5542-7.
2000: Y Hu; Carlos T Moraes; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs.
Biochemical pharmacology 2000;60(12):1897-905.
2000: J Zou; Howard Landy; Lynn Feun; R Xu; Theodore J Lampidis; C J Wu; Alex Furst; Niramol Savaraj
Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells.
Biochemical pharmacology 2000;60(9):1361-5.
1999: D Kolonias; T Podona; Niramol Savaraj; L Gate; P Cossum; Theodore J Lampidis
Comparison of annamycin to adriamycin in cardiac and MDR tumor cell systems.
Anticancer research 1999;19(2A):1277-83.
1998: Danièle Brouty-Boyé; Chantal Doucet; Denis Clay; MC Le Bousse-Kerdiles; Theodore J Lampidis; Bruno Azzarone
Phenotypic diversity in human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues.
International journal of cancer. Journal international du cancer 1998;76(5):767-73.
1998: Jean-Luc Teillaud; Nadège Gruel; Janine Moncuit; Z Mishal; Wolf H Fridman; Theodore J Lampidis; H Tapiero
Structurally different anthracyclines provoke different effects on cell cycle and tumor B cell differentiation.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1998;52(6):282-90.
1997: Niramol Savaraj; C J Wu; R Xu; Theodore J Lampidis; Shenghan Lai; E Donnelly; J Solomon; Lynn Feun
Multidrug-resistant gene expression in small-cell lung cancer.
American journal of clinical oncology 1997;20(4):398-403.
1997: Niramol Savaraj; R Xu; Howard Landy; Shenghan Lai; L Sternau; J Solomon; C Wu; Theodore J Lampidis; Lynn Feun
Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer.
Oncology reports 1997;4(4):857-61.
1997: Theodore J Lampidis; Y F Shi; C L Calderon; D Kolonias; H Tapiero; Niramol Savaraj
Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells.
Leukemia 1997;11(7):1156-9.
1997: Theodore J Lampidis; D Kolonias; T Podona; Mervyn Israel; A R Safa; Leonard Lothstein; Niramol Savaraj; H Tapiero; Waldemar Priebe
Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge.
Biochemistry 1997;36(9):2679-85.
1995: Danièle Brouty-Boyé; D Kolonias; C J Wu; Niramol Savaraj; Theodore J Lampidis
Relationship of multidrug resistance to rhodamine-123 selectivity between carcinoma and normal epithelial cells: taxol and vinblastine modulate drug efflux.
Cancer research 1995;55(8):1633-8.
1995: D Brouty-Boye; D Kolonias; Theodore J Lampidis
Antiproliferative activity of taxol on human tumor and normal breast cells vs. effects on cardiac cells.
International journal of cancer. Journal international du cancer 1995;60(4):571-5.
1994: Haim Tapiero; G Nguyen-Ba; Theodore J Lampidis
Cross resistance relevance of the chemical structure of different anthracyclines in multidrug resistant cells.
Pathologie-biologie 1994;42(4):328-37.
1994: Niramol Savaraj; Theodore J Lampidis; J Y Zhao; C J Wu; L D Teeter; M Tien Kuo
Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins.
Cancer investigation 1994;12(2):138-44.
1992: M Dellinger; G Moreno; C Salet; Haim Tapiero; Theodore J Lampidis
Cytotoxic and photodynamic effects of Photofrin on sensitive and multi-drug-resistant Friend leukaemia cells.
International journal of radiation biology 1992;62(6):735-41.
1992: M Dellinger; B C Pressman; C Calderon-Higginson; Niramol Savaraj; Haim Tapiero; D Kolonias; Theodore J Lampidis
Structural requirements of simple organic cations for recognition by multidrug-resistant cells.
Cancer research 1992;52(22):6385-9.
1992: D Brouty-Boye; D Kolonias; Niramol Savaraj; Theodore J Lampidis
Alpha-smooth muscle actin expression in cultured cardiac fibroblasts of newborn rat.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(4):293-6.
1992: Theodore J Lampidis; D Kolonias; Niramol Savaraj; R W Rubin
Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1256-60.
1990: Lynn Feun; Niramol Savaraj; Howard Landy; H Levin; Theodore J Lampidis
Phase II study of homoharringtonine in patients with recurrent primary malignant central nervous system tumors.
Journal of neuro-oncology 1990;9(2):159-63.
1990: N Horichi; Haim Tapiero; Y Sugimoto; M Bungo; M Nishiyama; A Fourcade; Theodore J Lampidis; K Kasahara; Yasutsuna Sasaki; T Takahashi
3'-Deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin conquers multidrug resistance by rapid influx following higher frequency of formation of DNA single- and double-strand breaks.
Cancer research 1990;50(15):4698-701.
1989: Theodore J Lampidis; C Castello; A del Giglio; B C Pressman; P Viallet; K W Trevorrow; G K Valet; Haim Tapiero; Niramol Savaraj
Relevance of the chemical charge of rhodamine dyes to multiple drug resistance.
Biochemical pharmacology 1989;38(23):4267-71.
1989: M Hasmann; G K Valet; Haim Tapiero; K Trevorrow; Theodore J Lampidis
Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry.
Biochemical pharmacology 1989;38(2):305-12.
1988: Haim Tapiero; D Boulé; G Trincal; A Fourcade; Theodore J Lampidis
Potentiation of adriamycin accumulation and effectiveness in adriamycin-resistant cells by aclacinomycin A.
Leukemia research 1988;12(5):411-8.
1986: Haim Tapiero; A Sbarbati; A Fourcade; S Cinti; Theodore J Lampidis
Effect of verapamil on rhodamine 123 mitochondrial damage in adriamycin resistant cells.
Anticancer research 1986;6(5):1073-6.
1986: Theodore J Lampidis; K W Trevorrow; R W Rubin
Effects of colchicine on cardiac cell function indicate possible role for membrane surface tubulin.
Experimental cell research 1986;164(2):463-70.
1986: Theodore J Lampidis; AWTAR KRISHAN; L Planas; Haim Tapiero
Reversal of intrinsic resistance to adriamycin in normal cells by verapamil.
Cancer drug delivery 1986;3(4):251-9.
1986: Haim Tapiero; A Fourcade; J N Munck; Georges Zwingelstein; Theodore J Lampidis
Cellular pharmacology of anthracycline resistance and its circumvention.
Drugs under experimental and clinical research 1986;12(1-3):265-73.
1985: S Davis; M J Weiss; J R Wong; Theodore J Lampidis; L B Chen
Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.
The Journal of biological chemistry 1985;260(25):13844-50.
1985: Theodore J Lampidis; J N Munck; AWTAR KRISHAN; Haim Tapiero
Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.
Cancer research 1985;45(6):2626-31.
1985: S Abou-Khalil; W H Abou-Khalil; L Planas; Haim Tapiero; Theodore J Lampidis
Interaction of rhodamine 123 with mitochondria isolated from drug-sensitive and -resistant Friend leukemia cells.
Biochemical and biophysical research communications 1985;127(3):1039-44.
1985: Theodore J Lampidis; Y Hasin; M J Weiss; L B Chen
Selective killing of carcinoma cells "in vitro" by lipophilic-cationic compounds: a cellular basis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1985;39(5):220-6.
1984: Haim Tapiero; J N Munck; A Fourcade; Theodore J Lampidis
Cross-resistance to rhodamine 123 in Adriamycin- and daunorubicin-resistant Friend leukemia cell variants.
Cancer research 1984;44(12 Pt 1):5544-9.
1984: Theodore J Lampidis; C Salet; G Moreno; L B Chen
Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture.
Agents and actions 1984;14(5-6):751-7.
1983: S D Bernal; Theodore J Lampidis; R M McIsaac; L B Chen
Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.
Science (New York, N.Y.) 1983;222(4620):169-72.
1983: Theodore J Lampidis; S D Bernal; I C Summerhayes; Lan Bo Chen
Selective toxicity of rhodamine 123 in carcinoma cells in vitro.
Cancer research 1983;43(2):716-20.
1982: S D Bernal; Theodore J Lampidis; I C Summerhayes; L B Chen
Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro.
Science (New York, N.Y.) 1982;218(4577):1117-9.
1982: I C Summerhayes; Theodore J Lampidis; S D Bernal; J J Nadakavukaren; K K Nadakavukaren; E L Shepherd; L B Chen
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(17):5292-6.
1982: L B Chen; I C Summerhayes; L V Johnson; M L Walsh; S D Bernal; Theodore J Lampidis
Probing mitochondria in living cells with rhodamine 123.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 1():141-55.
1981: Theodore J Lampidis; L V Johnson; M Israel
Effects of adriamycin on rat heart cells in culture: increased accumulation and nucleoli fragmentation in cardiac muscle v. non-muscle cells.
Journal of molecular and cellular cardiology 1981;13(10):913-24.
1981: Theodore J Lampidis; Danièle Brouty-Boyé
Interferon inhibits cardiac cell function in vitro.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1981;166(2):181-5.
1980: Theodore J Lampidis; I C Henderson; M Israel; George P Canellos
Structural and functional effects of adriamycin on cardiac cells in vitro.
Cancer research 1980;40(11):3901-9.
1979: Theodore J Lampidis; G Moreno; C Salet; F Vinzens
Nuclear and mitochondrial effects of adriamycin in singly isolated pulsating myocardial cells.
Journal of molecular and cellular cardiology 1979;11(4):415-22.
1977: Theodore J Lampidis; J B Little
Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea. Demonstration by combined biochemical and autoradiographic techniques.
Experimental cell research 1977;110(1):41-6.
1975: Theodore J Lampidis; G E Schaiberger
Age-related loss of DNA repair synthesis in isolated rat myocardial cells.
Experimental cell research 1975;96(2):412-6.
1975: Theodore J Lampidis; R R Weichselbaum; J B Little
Letter: Gamma-irradiation of mammalian beating heart cells in vitro. Effects on cellular function.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1975;28(1):99-102.
1971: Theodore J Lampidis; L Barksdale
Park-Williams number 8 strain of Corynebacterium diphtheriae.
Journal of bacteriology 1971;105(1):77-85.