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Rainer Landgraf

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Claudia Schmuckermair; gaburro stefano; Rainer Landgraf; Anupam Sah; Simone B Sartori; Nicolas Singewald
Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior.
Julien Dine; Matthias Eder; Florian Holsboer; Irina A Ionescu; Rainer Landgraf; Jens Stepan; Yi-Chun Yen; Ulrike Schmidt
Identification of a role for the ventral hippocampus in neuropeptide s-elicited anxiolysis.
Inga D Neumann; Rainer Landgraf
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors.

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2013: Claudia Schmuckermair; gaburro stefano; Rainer Landgraf; Anupam Sah; Simone B Sartori; Nicolas Singewald
Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(7):1234-44.
2013: Julien Dine; Matthias Eder; Florian Holsboer; Irina A Ionescu; Rainer Landgraf; Jens Stepan; Yi-Chun Yen; Ulrike Schmidt
Identification of a role for the ventral hippocampus in neuropeptide s-elicited anxiolysis.
PloS one 2013;8(3):e60219.
2012: Inga D Neumann; Rainer Landgraf
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors.
Trends in neurosciences 2012;35(11):649-59.
2012: Michaela D Filiou; Elisabeth Frank; Philipp Gormanns; Melanie Keßler; Rainer Landgraf; Giuseppina Maccarrone; Stefan Reckow; Larysa Teplytska; Christian Webhofer; Yaoyang Zhang; Birgit Bisle; Christoph W Turck
The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model.
Proteomics 2012;12(15-16):2421-7.
2012: Yi-Chun Yen; Mirjam Bunck; Maik Dahlhoff; Rainer Landgraf; Christoph P Mauch; Vincenzo Micale; Simone B Sartori; Nicolas Singewald; Carsten T Wotjak
Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety.
Neurobiology of learning and memory 2012;98(1):56-65.
2012: Irina A Ionescu; Rainer Landgraf; Yi-Chun Yen; Dominik R Buell; Julien Dine; Matthias Eder; Leonie Herrmann; Florian Holsboer; Ulrike Schmidt
Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(6):1323-37.
2012: Alana Knapman; Rainer Landgraf; Daniel Martins-de-Souza; Michael Czisch; Florian Holsboer; Sebastian F Kaltwasser; Christoph W Turck; Chadi Touma
Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism.
The European journal of neuroscience 2012;35(3):412-22.
2012: Mariya Gonik; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Bertram Müller-Myhsok; Benno Pütz; Chadi Touma; Yi-Chun Yen; Thomas Bettecken; Mirjam Bunck; Darina Czamara; Elisabeth Frank; Ludwig Czibere
The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety.
BMC genomics 2012;13():579.
2012: A Sah; S B Sartori; C Schmuckermair; L Aigner; gaburro stefano; R Irschick; M Kandasamy; L Klimaschewski; Rainer Landgraf; Nicolas Singewald
Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.
Translational psychiatry 2012;2():e171.
2012: Vladimira Jakubcakova; Cornelia Flachskamm; Rainer Landgraf; Mayumi Kimura
Sleep phenotyping in a mouse model of extreme trait anxiety.
PloS one 2012;7(7):e40625.
2012: Anup G Pillai; Danielle de Jong; Jan-Michael Heinzmann; Florian Holsboer; Marian Joëls; Sofia Kanatsou; Alana Knapman; Harm Krugers; Rainer Landgraf; Chadi Touma
Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity.
PloS one 2012;7(6):e38971.
2011: Yaoyang Zhang; Michaela D Filiou; Elisabeth Frank; Philipp Gormanns; Boris Hambsch; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Giuseppina Maccarrone; Stefan Reckow; Christoph W Turck
Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways.
Molecular & cellular proteomics : MCP 2011;10(12):M111.008110.
2011: Michaela D Filiou; Elisabeth Frank; Philipp Gormanns; Boris Hambsch; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Tonia Ludwig; Giuseppina Maccarrone; Markus Nussbaumer; Stefan Reckow; Larysa Teplytska; Alexander Yassouridis; Yaoyang Zhang; Mirjam Bunck; Christoph W Turck
Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways.
Biological psychiatry 2011;70(11):1074-82.
2011: gaburro stefano; Pietro Giusti; Rainer Landgraf; Simone B Sartori; Oliver Stiedl; Nicolas Singewald
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2011;14(10):1341-55.
2011: Michael Lukas; Remco Bredewold; Rainer Landgraf; Inga D Neumann; Alexa H Veenema
Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats.
Psychoneuroendocrinology 2011;36(6):843-53.
2011: Ludwig Czibere; Nafees Ahmad; Laura A Baur; Mirjam Bunck; Katja Gemmeke; Cornelia Graf; Boris Hambsch; Florian Holsboer; Claudia Kühne; Rainer Landgraf; Markus Panhuysen; Christoph Peters; Benno Pütz; Thomas Reinheckel; Gabriele Rieder; Andrea Steiner; Peter Weber; Regina Widner; Anke Wittmann; Jan M Deussing
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.
PloS one 2011;6(8):e23604.
2011: Thomas Fenzl; Chadi Touma; Christoph Pn Romanowski; Jörg Ruschel; Florian Holsboer; Rainer Landgraf; Mayumi Kimura; Alexander Yassouridis
Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression.
BMC neuroscience 2011;12():29.
2011: Simone B Sartori; Markus Hauschild; Mirjam Bunck; Stefano Gaburro; Rainer Landgraf; Nicolas Singewald
Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.
PloS one 2011;6(2):e16849.
2011: Melanie Keßler; Oliver J Bosch; Mirjam Bunck; Rainer Landgraf; Inga D Neumann
Maternal care differs in mice bred for high vs. low trait anxiety: impact of brain vasopressin and cross-fostering.
Social neuroscience 2011;6(2):156-68.
2010: J-M Heinzmann; Christoph K Thoeringer; Alana Knapman; Rupert Palme; Florian Holsboer; Manfred Uhr; Rainer Landgraf; Chadi Touma
Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study.
Journal of neuroendocrinology 2010;22(11):1187-97.
2010: Alana Knapman; J-M Heinzmann; Florian Holsboer; Rainer Landgraf; Chadi Touma
Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice.
Neurobiology of learning and memory 2010;94(2):145-52.
2010: Jan M Deussing; Johannes Breu; Claudia Kühne; Magdalena Kallnik; Mirjam Bunck; Lisa Glasl; Yi-Chun Yen; Mathias V Schmidt; Regine Zurmühlen; Annette M Vogl; Valérie Gailus-Durner; Helmut Fuchs; Sabine M Hölter; Carsten T Wotjak; Rainer Landgraf; Martin Hrabé De Angelis; Florian Holsboer; Wolfgang Wurst
Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(27):9103-16.
2010: Alana Knapman; J-M Heinzmann; Rainer Hellweg; Florian Holsboer; Rainer Landgraf; Chadi Touma
Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders.
Journal of psychiatric research 2010;44(9):566-75.
2010: C Ditzen; J Varadarajulu; Ludwig Czibere; M Gonik; B S Targosz; B Hambsch; Thomas Bettecken; Melanie Keßler; Elisabeth Frank; Mirjam Bunck; Larysa Teplytska; Erhardt Angelika; Florian Holsboer; Bertram Müller-Myhsok; Rainer Landgraf; Christoph W Turck
Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways.
Molecular psychiatry 2010;15(7):702-11.
2010: Boris Hambsch; Bud-Gen Chen; Julia Brenndörfer; Melanie Meyer; Charilaos Avrabos; Giuseppina Maccarrone; Ray H Liu; Matthias Eder; Christoph W Turck; Rainer Landgraf
Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain.
Journal of neurochemistry 2010;113(5):1240-51.
2010: Oliver J Bosch; J Pförtsch; Daniela I Beiderbeck; Rainer Landgraf; Inga D Neumann
Maternal behaviour is associated with vasopressin release in the medial preoptic area and bed nucleus of the stria terminalis in the rat.
Journal of neuroendocrinology 2010;22(5):420-9.
2010: Amalia F Tsolakidou; Ludwig Czibere; Benno Pütz; Dietrich Trümbach; Markus Panhuysen; Jan M Deussing; Wolfgang Wurst; Inge Sillaber; Rainer Landgraf; Florian Holsboer; Theo Rein
Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein.
BMC genomics 2010;11():546.
2009: Elisabeth Frank; Melanie Keßler; Michaela D Filiou; Yaoyang Zhang; Giuseppina Maccarrone; Stefan Reckow; Mirjam Bunck; Hermann Heumann; Christoph W Turck; Rainer Landgraf; Boris Hambsch
Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies.
PloS one 2009;4(11):e7821.
2009: Patrik Muigg; Sandra Scheiber; Peter Salchner; Mirjam Bunck; Rainer Landgraf; Nicolas Singewald
Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety.
PloS one 2009;4(4):e5346.
2009: Mirjam Bunck; Ludwig Czibere; Charlotte Horvath; Cornelia Graf; Elisabeth Frank; Melanie Keßler; Chris Murgatroyd; Bertram Müller-Myhsok; Mariya Gonik; Peter Weber; Benno Pütz; Patrik Muigg; Markus Panhuysen; Nicolas Singewald; Thomas Bettecken; Jan M Deussing; Florian Holsboer; Dietmar Spengler; Rainer Landgraf
A hypomorphic vasopressin allele prevents anxiety-related behavior.
PloS one 2009;4(4):e5129.
2009: Chadi Touma; Thomas Fenzl; Jörg Ruschel; Rupert Palme; Florian Holsboer; Mayumi Kimura; Rainer Landgraf
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression.
PloS one 2009;4(1):e4325.
2008: Patrik Muigg; Alfred Hetzenauer; Gabriele Hauer; Markus Hauschild; gaburro stefano; Elisabeth Frank; Rainer Landgraf; Nicolas Singewald
Impaired extinction of learned fear in rats selectively bred for high anxiety--evidence of altered neuronal processing in prefrontal-amygdala pathways.
The European journal of neuroscience 2008;28(11):2299-309.
2008: Carsten T Wotjak; Rainer Landgraf; Mario Engelmann
Listening to neuropeptides by microdialysis: echoes and new sounds?
Pharmacology, biochemistry, and behavior 2008;90(2):125-34.
2008: Chadi Touma; Mirjam Bunck; Lisa Glasl; Markus Nussbaumer; Rupert Palme; Hendrik Stein; Michael Wolferstätter; Ramona Zeh; Marina Zimbelmann; Florian Holsboer; Rainer Landgraf
Mice selected for high versus low stress reactivity: a new animal model for affective disorders.
Psychoneuroendocrinology 2008;33(6):839-62.
2008: Elisabeth Frank; Rainer Landgraf
The vasopressin system--from antidiuresis to psychopathology.
European journal of pharmacology 2008;583(2-3):226-42.
2007: Melanie Keßler; Chris Murgatroyd; Mirjam Bunck; Ludwig Czibere; Elisabeth Frank; Wolfgang Jacob; Charlotte Horvath; Patrik Muigg; Florian Holsboer; Nicolas Singewald; Dietmar Spengler; Rainer Landgraf
Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.
The European journal of neuroscience 2007;26(10):2857-64.
2007: Patrik Muigg; Ulrike Hoelzl; Klara Palfrader; Inga Neumann; Alexandra Wigger; Rainer Landgraf; Nicolas Singewald
Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety.
Biological psychiatry 2007;61(6):782-96.
2007: Rudolph Marsch; Elisabeth Foeller; Gerhard Rammes; Mirjam Bunck; Manfred Kössl; Florian Holsboer; Walter Zieglgänsberger; Rainer Landgraf; Beat Lutz; Carsten T Wotjak
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):832-9.
2007: Rainer Landgraf; Melanie Keßler; Mirjam Bunck; Chris Murgatroyd; Dietmar Spengler; Marina Zimbelmann; Markus Nussbaumer; Ludwig Czibere; Christoph W Turck; Nicolas Singewald; Dan Rujescu; Elisabeth Frank
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I.
Neuroscience and biobehavioral reviews 2007;31(1):89-102.
2006: Tobias Welt; Mario Engelmann; Ulrich Renner; Erhardt Angelika; Marianne B Müller; Rainer Landgraf; Florian Holsboer; Martin E Keck
Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2573-9.
2006: Claudia Ditzen; Archana M Jastorff; Melanie Keßler; Mirjam Bunck; Larysa Teplytska; Erhardt Angelika; Simone A Krömer; Jeeva Varadarajulu; Bianca-Sabrina Targosz; Eser F Sayan-Ayata; Florian Holsboer; Rainer Landgraf; Christoph W Turck
Protein biomarkers in a mouse model of extremes in trait anxiety.
Molecular & cellular proteomics : MCP 2006;5(10):1914-20.
2006: Nicolas Salomé; Odile Viltart; Jean Lesage; Rainer Landgraf; Didier Vieau; Christine Laborie
Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates.
Psychoneuroendocrinology 2006;31(6):724-35.
2006: Nicolas Salomé; Rainer Landgraf; Odile Viltart
Confinement to the open arm of the elevated-plus maze as anxiety paradigm: behavioral validation.
Behavioral neuroscience 2006;120(3):719-23.
2006: Peter Salchner; Simone B Sartori; Catrin Sinner; Alexandra Wigger; Elisabeth Frank; Rainer Landgraf; Nicolas Singewald
Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior.
Neuropharmacology 2006;50(8):1048-58.
2006: Raffael Kalisch; Mirjam Schubert; Wolfgang Jacob; Melanie Keßler; Rosa Hemauer; Alexandra Wigger; Rainer Landgraf; Dorothee P Auer
Anxiety and hippocampus volume in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(5):925-32.
2006: Rainer Landgraf
The involvement of the vasopressin system in stress-related disorders.
CNS & neurological disorders drug targets 2006;5(2):167-79.
2006: Elisabeth Frank; Peter Salchner; J Matthew Aldag; Nicolas Salomé; Nicolas Singewald; Rainer Landgraf; Alexandra Wigger
Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat.
Behavioral neuroscience 2006;120(1):60-71.
2005: Simone A Krömer; Melanie Keßler; Dale Milfay; Isabel Birg; Mirjam Bunck; Ludwig Czibere; Markus Panhuysen; Benno Pütz; Jan M Deussing; Florian Holsboer; Rainer Landgraf; Christoph W Turck
Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4375-84.
2005: Martin E Keck; Simone B Sartori; Tobias Welt; Marianne B Müller; frauke ohl; Florian Holsboer; Rainer Landgraf; Nicolas Singewald
Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment.
Journal of neurochemistry 2005;92(5):1170-9.
2005: Inga D Neumann; Alexandra Wigger; Simone A Krömer; Ellen Frank; Rainer Landgraf; Oliver J Bosch
Differential effects of periodic maternal separation on adult stress coping in a rat model of extremes in trait anxiety.
Neuroscience 2005;132(3):867-77.
2004: Rainer Landgraf; Inga D Neumann
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication.
Frontiers in neuroendocrinology 2004;25(3-4):150-76.
2004: Chris Murgatroyd; Alexandra Wigger; Elisabeth Frank; Nicolas Singewald; Mirjam Bunck; Florian Holsboer; Rainer Landgraf; Dietmar Spengler
Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(35):7762-70.
2004: Raffael Kalisch; Nicolas Salomé; Stefan Platzer; Alexandra Wigger; Michael Czisch; Wolfgang Sommer; Nicolas Singewald; Markus Heilig; Achim Berthele; Florian Holsboer; Rainer Landgraf; Dorothee P Auer
High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats.
NeuroImage 2004;23(1):382-91.
2004: Ulrich Zimmermann; Konstanze Spring; Hans-Ulrich Wittchen; Hubertus Himmerich; Rainer Landgraf; Manfred Uhr; Florian Holsboer
Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers.
Journal of psychiatric research 2004;38(4):385-93.
2004: Nicolas Salomé; Peter Salchner; Odile Viltart; Henrique Sequeira; Alexandra Wigger; Rainer Landgraf; Nicolas Singewald
Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats.
Biological psychiatry 2004;55(7):715-23.
2004: Alexandra Wigger; Mar M Sánchez; Kenneth C Mathys; Karl Ebner; Elisabeth Frank; Dong Liu; Adelheid E Kresse; Inga D Neumann; Florian Holsboer; Paul M Plotsky; Rainer Landgraf
Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):1-14.
2003: Marianne B Müller; Martin E Keck; Elisabeth B Binder; Adelheid E Kresse; Thomas P Hagemeyer; Rainer Landgraf; Florian Holsboer; Manfred Uhr
ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1991-9.
2003: Rainer Landgraf; Elisabeth Frank; John M Aldag; Inga D Neumann; Catherine A Sharer; Xianghui Ren; Ernest F Terwilliger; Masanobu Niwa; Alexandra Wigger; Larry J Young
Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour.
The European journal of neuroscience 2003;18(2):403-11.
2003: Rainer Landgraf; Alexandra Wigger
Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats.
Stress (Amsterdam, Netherlands) 2003;6(2):111-9.
2003: Rainer Landgraf
[Neurobiology and genetics of anxiety in an animal model].
Der Nervenarzt 2003;74(3):274-8.
2003: Martin E Keck; Tobias Welt; Marianne B Müller; Manfred Uhr; frauke ohl; Alexandra Wigger; Nicola Toschi; Florian Holsboer; Rainer Landgraf
Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):235-43.
2003: Martin E Keck; Tobias Welt; Marianne B Müller; Rainer Landgraf; Florian Holsboer
The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats.
Pharmacopsychiatry 2003;36(1):27-31.
2002: Nicolas Salomé; Odile Viltart; MURIEL DARNAUDERY; Peter Salchner; Nicolas Singewald; Rainer Landgraf; Henrique Sequeira; Alexandra Wigger
Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis.
Behavioural brain research 2002;136(1):227-37.
2002: Jürgen Brunner; Martin E Keck; Rainer Landgraf; Manfred Uhr; Christian Namendorf; Thomas Bronisch
Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2002;12(5):489-94.
2002: Rainer Landgraf; Alexandra Wigger
High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety.
Behavior genetics 2002;32(5):301-14.
2002: Carsten T Wotjak; Mike Ludwig; Karl Ebner; John A Russell; Nicolas Singewald; Rainer Landgraf; Mario Engelmann
Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion.
The European journal of neuroscience 2002;16(3):477-85.
2002: Marike Lancel; Peter Müller-Preuss; Alexandra Wigger; Rainer Landgraf; Florian Holsboer
The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety.
Journal of psychiatric research 2002;36(4):197-208.
2002: frauke ohl; Angelika Roedel; Corinna Storch; Florian Holsboer; Rainer Landgraf
Cognitive performance in rats differing in their inborn anxiety.
Behavioral neuroscience 2002;116(3):464-71.
2002: Markus S H Henniger; Rainer Spanagel; Alexandra Wigger; Rainer Landgraf; Sabine M Hölter
Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(6):729-36.
2002: Karl Ebner; Carsten T Wotjak; Rainer Landgraf; Mario Engelmann
Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats.
The European journal of neuroscience 2002;15(2):384-8.
2002: Martin E Keck; Alexandra Wigger; Tobias Welt; Marianne B Müller; Angela Gesing; Johannes M H M Reul; Florian Holsboer; Rainer Landgraf; Inga D Neumann
Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(1):94-105.
2001: Rainer Landgraf
Neuropeptides and anxiety.
Stress (Amsterdam, Netherlands) 2001;4(4):273-6.
2001: Rainer Landgraf
Neuropeptides and anxiety-related behavior.
Endocrine journal 2001;48(5):517-33.
2001: Alexandra Wigger; P Loerscher; P Weissenbacher; Florian Holsboer; Rainer Landgraf
Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety.
Behavior genetics 2001;31(4):371-82.
2001: Carsten T Wotjak; T Naruo; S Muraoka; R Simchen; Rainer Landgraf; Mario Engelmann
Forced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus.
The European journal of neuroscience 2001;13(12):2273-81.
2001: Luz Torner; Nicola Toschi; A Pohlinger; Rainer Landgraf; Inga D Neumann
Anxiolytic and anti-stress effects of brain prolactin: improved efficacy of antisense targeting of the prolactin receptor by molecular modeling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3207-14.
2001: frauke ohl; Nicola Toschi; Alexandra Wigger; Markus S H Henniger; Rainer Landgraf
Dimensions of emotionality in a rat model of innate anxiety.
Behavioral neuroscience 2001;115(2):429-36.
2001: Martin E Keck; Tobias Welt; Anke Post; Marianne B Müller; Nicola Toschi; Alexandra Wigger; Rainer Landgraf; Florian Holsboer; Mario Engelmann
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(4):337-49.
2001: Martin E Keck; Tobias Welt; Alexandra Wigger; Ulrich Renner; Mario Engelmann; Florian Holsboer; Rainer Landgraf
The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.
The European journal of neuroscience 2001;13(2):373-80.
2000: Marianne B Müller; Rainer Landgraf; J Preil; Inge Sillaber; Adelheid E Kresse; Martin E Keck; Stephan Zimmermann; Florian Holsboer; Wolfgang Wurst
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
Endocrinology 2000;141(11):4262-9.
2000: Martin E Keck; Inge Sillaber; Karl Ebner; Tobias Welt; Nicola Toschi; Stefan T Kaehler; Nicolas Singewald; Athineos Philippou; Gregor Elbel; Carsten T Wotjak; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain.
The European journal of neuroscience 2000;12(10):3713-20.
2000: Marianne B Müller; Rainer Landgraf; Martin E Keck
Vasopressin, major depression, and hypothalamic-pituitary-adrenocortical desensitization.
Biological psychiatry 2000;48(4):330-3.
2000: HA Johnstone; Alexandra Wigger; Alison J Douglas; Inga D Neumann; Rainer Landgraf; J R Seckl; John A Russell
Attenuation of hypothalamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms.
Journal of neuroendocrinology 2000;12(8):811-22.
2000: Karl Ebner; Carsten T Wotjak; Rainer Landgraf; Mario Engelmann
A single social defeat experience selectively stimulates the release of oxytocin, but not vasopressin, within the septal brain area of male rats.
Brain research 2000;872(1-2):87-92.
2000: Martin E Keck; Mario Engelmann; Marianne B Müller; Markus S H Henniger; Bettina Hermann; Rainer Rupprecht; Inga D Neumann; Nicola Toschi; Rainer Landgraf; Anke Post
Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats.
Journal of psychiatric research 2000;34(4-5):265-76.
2000: Markus S H Henniger; frauke ohl; Sabine M Hölter; P Weissenbacher; Nicola Toschi; P Lörscher; Alexandra Wigger; Rainer Spanagel; Rainer Landgraf
Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour.
Behavioural brain research 2000;111(1-2):153-63.
2000: Martin E Keck; M Hatzinger; Carsten T Wotjak; Rainer Landgraf; Florian Holsboer; Inga D Neumann
Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats.
The European journal of neuroscience 2000;12(4):1487-94.
2000: Inga D Neumann; Alexandra Wigger; Luz Torner; Florian Holsboer; Rainer Landgraf
Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus.
Journal of neuroendocrinology 2000;12(3):235-43.
2000: DE Dluzen; S Muraoka; Mario Engelmann; Karl Ebner; Rainer Landgraf
Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.
The European journal of neuroscience 2000;12(2):760-6.
2000: M Hatzinger; Carsten T Wotjak; T Naruo; R Simchen; Martin E Keck; Rainer Landgraf; Florian Holsboer; Inga D Neumann
Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats.
The Journal of endocrinology 2000;164(2):197-205.
1999: Mario Engelmann; Karl Ebner; Rainer Landgraf; Florian Holsboer; C T Wotjak1
Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats.
Journal of neuroendocrinology 1999;11(11):867-72.
1999: Thomas Stoehr; Osborne Almeida; Rainer Landgraf; T S Shippenberg; Florian Holsboer; Rainer Spanagel
Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats.
Behavioural brain research 1999;103(1):85-93.
1999: Rainer Landgraf; Alexandra Wigger; Florian Holsboer; Inga D Neumann
Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour.
Journal of neuroendocrinology 1999;11(6):405-7.
1999: G Liebsch; Rainer Landgraf; Mario Engelmann; P Lörscher; Florian Holsboer
Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain.
Journal of psychiatric research 1999;33(2):153-63.
1999: Karl Ebner; Carsten T Wotjak; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Vasopressin released within the septal brain area during swim stress modulates the behavioural stress response in rats.
The European journal of neuroscience 1999;11(3):997-1002.
1998: Mario Engelmann; Rainer Landgraf; P Lörscher; C Conzelmann; JC Probst; Florian Holsboer; Johannes M H M Reul
Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats.
European journal of pharmacology 1998;361(1):17-26.
1998: G Liebsch; Astrid C E Linthorst; Inga D Neumann; Johannes M H M Reul; Florian Holsboer; Rainer Landgraf
Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):381-96.
1998: DE Dluzen; S Muraoka; Rainer Landgraf
Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.
Neuroscience letters 1998;254(3):161-4.
1998: Alison J Douglas; HA Johnstone; Alexandra Wigger; Rainer Landgraf; John A Russell; Inga D Neumann
The role of endogenous opioids in neurohypophysial and hypothalamo-pituitary-adrenal axis hormone secretory responses to stress in pregnant rats.
The Journal of endocrinology 1998;158(2):285-93.
1998: G Liebsch; Alexandra Montkowski; Florian Holsboer; Rainer Landgraf
Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour.
Behavioural brain research 1998;94(2):301-10.
1998: Carsten T Wotjak; J Ganster; G Kohl; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons.
Neuroscience 1998;85(4):1209-22.
1998: Inga D Neumann; Alexandra Wigger; G Liebsch; Florian Holsboer; Rainer Landgraf
Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour.
Psychoneuroendocrinology 1998;23(5):449-63.
1998: Inge Sillaber; Alexandra Montkowski; Rainer Landgraf; Nicholas Barden; Florian Holsboer; Rainer Spanagel
Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide.
Neuroscience 1998;85(2):415-25.
1998: Mario Engelmann; Karl Ebner; Rainer Landgraf; Carsten T Wotjak
Swim stress triggers the release of vasopressin within the suprachiasmatic nucleus of male rats.
Brain research 1998;792(2):343-7.
1998: Inga D Neumann; HA Johnstone; M Hatzinger; G Liebsch; M Shipston; John A Russell; Rainer Landgraf; Alison J Douglas
Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes.
The Journal of physiology 1998;508 ( Pt 1)():289-300.
1998: Sabine M Hölter; Mario Engelmann; Christian Kirschke; G Liebsch; Rainer Landgraf; Rainer Spanagel
Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats.
Behavioural pharmacology 1998;9(1):41-8.
1998: Rainer Landgraf; Carsten T Wotjak; Inga D Neumann; Mario Engelmann
Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation.
Progress in brain research 1998;119():201-20.
1998: Mario Engelmann; Carsten T Wotjak; Rainer Landgraf
Differential central and peripheral release of vasopressin and oxytocin in response to swim stress in rats.
Advances in experimental medicine and biology 1998;449():175-7.
1998: DE Dluzen; S Muraoka; Mario Engelmann; Rainer Landgraf
The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.
Peptides 1998;19(6):999-1005.
1998: Mario Engelmann; Karl Ebner; Carsten T Wotjak; Rainer Landgraf
Endogenous oxytocin is involved in short-term olfactory memory in female rats.
Behavioural brain research 1998;90(1):89-94.
1997: Rainer Landgraf; T Naruo; M Vecsernyes; Inga Neumann
Neuroendocrine and behavioral effects of antisense oligonucleotides.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(4):326-35.
1997: Alexandra Montkowski; Rainer Landgraf; A Yassouridis; F Holsboer; B Schöbitz
Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats.
Pharmacology, biochemistry, and behavior 1997;58(2):329-36.
1997: Sabine M Hölter; Rainer Landgraf; Walter Zieglgänsberger; Rainer Spanagel
Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation.
Alcoholism, clinical and experimental research 1997;21(5):862-8.
1997: Colin H Brown; G Munro; Louise E Johnstone; A C Robson; Rainer Landgraf; John A Russell
Oxytocin neurone autoexcitation during morphine withdrawal in anaesthetized rats.
Neuroreport 1997;8(4):951-5.
1997: A Ströhle; Holger Jahn; Alexandra Montkowski; G Liebsch; E Boll; Rainer Landgraf; Florian Holsboer; Klaus Wiedemann
Central and peripheral administration of atriopeptin is anxiolytic in rats.
Neuroendocrinology 1997;65(3):210-5.
1997: Johannes M H M Reul; JC Probst; Thomas Skutella; M Hirschmann; IS Stec; Alexandra Montkowski; Rainer Landgraf; Florian Holsboer
Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.
Neuroendocrinology 1997;65(3):189-99.
1997: M Ludwig; Louise E Johnstone; I Neumann; Rainer Landgraf; John A Russell
Direct hypertonic stimulation of the rat supraoptic nucleus increases c-fos expressionin glial cells rather than magnocellular neurones.
Cell and tissue research 1997;287(1):79-90.
1996: Rainer Landgraf
Antisense targeting in behavioural neuroendocrinology.
The Journal of endocrinology 1996;151(3):333-40.
1996: Carsten T Wotjak; M Kubota; G Liebsch; Alexandra Montkowski; Florian Holsboer; I Neumann; Rainer Landgraf
Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion?
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7725-32.
1996: JC Probst; T Zetzsche; M Weber; P Theilemann; Thomas Skutella; Rainer Landgraf; G F Jirikowski
Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1518-23.
1996: M Hatzinger; Johannes M H M Reul; Rainer Landgraf; Florian Holsboer; I Neumann
Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging.
Neuroendocrinology 1996;64(5):349-56.
1996: G Liebsch; Carsten T Wotjak; Rainer Landgraf; Mario Engelmann
Septal vasopressin modulates anxiety-related behaviour in rats.
Neuroscience letters 1996;217(2-3):101-4.
1996: M Kubota; Rainer Landgraf; Carsten T Wotjak
Release of vasopressin within the rat suprachiasmatic nucleus: no effect of a V1/V2 antagonist.
Neuroreport 1996;7(12):1933-6.
1996: Carsten T Wotjak; M Kubota; G Kohl; Rainer Landgraf
Release of vasopressin from supraoptic neurons within the median eminence in vivo. A combined microdialysis and push-pull perfusion study in the rat.
Brain research 1996;726(1-2):237-41.
1996: Rainer Spanagel; Sabine M Hölter; K Allingham; Rainer Landgraf; Walter Zieglgänsberger
Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat.
European journal of pharmacology 1996;305(1-3):39-44.
1996: Mario Engelmann; Kv Thrivikraman; Y Su; Charles Nemeroff; Alexandra Montkowski; Rainer Landgraf; Florian Holsboer; Paul M Plotsky
Endocrine and behavioral effects of airpuff-startle in rats.
Psychoneuroendocrinology 1996;21(4):391-400.
1996: I Neumann; Alison J Douglas; Q J Pittman; John A Russell; Rainer Landgraf
Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events.
Journal of neuroendocrinology 1996;8(3):227-33.
1996: Mario Engelmann; Carsten T Wotjak; I Neumann; M Ludwig; Rainer Landgraf
Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory.
Neuroscience and biobehavioral reviews 1996;20(3):341-58.
1995: Rainer Spanagel; Alexandra Montkowski; K Allingham; Thomas Stoehr; M Shoaib; Florian Holsboer; Rainer Landgraf
Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats.
Psychopharmacology 1995;122(4):369-73.
1995: Alexandra Montkowski; N Barden; Carsten T Wotjak; I Stec; J Ganster; M Meaney; Mario Engelmann; Johannes M H M Reul; Rainer Landgraf; Florian Holsboer
Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1995;7(11):841-5.
1995: G Liebsch; Rainer Landgraf; R Gerstberger; JC Probst; Carsten T Wotjak; Mario Engelmann; Florian Holsboer; Alexandra Montkowski
Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats.
Regulatory peptides 1995;59(2):229-39.
1995: Andries Kalsbeek; R M Buijs; Mario Engelmann; Carsten T Wotjak; Rainer Landgraf
In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus.
Brain research 1995;682(1-2):75-82.
1995: Rainer Landgraf; R Gerstberger; Alexandra Montkowski; JC Probst; Carsten T Wotjak; Florian Holsboer; Mario Engelmann
V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4250-8.
1995: I Neumann; Rainer Landgraf; L Bauce; Q J Pittman
Osmotic responsiveness and cross talk involving oxytocin, but not vasopressin or amino acids, between the supraoptic nuclei in virgin and lactating rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3408-17.
1995: Rainer Landgraf
Mortyn Jones Memorial Lecture. Intracerebrally released vasopressin and oxytocin: measurement, mechanisms and behavioural consequences.
Journal of neuroendocrinology 1995;7(4):243-53.
1995: Rainer Landgraf; I Neumann; Florian Holsboer; Q J Pittman
Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat.
The European journal of neuroscience 1995;7(4):592-8.
1995: I Neumann; Q J Pittman; Rainer Landgraf
Release of oxytocin within the supraoptic nucleus. Mechanisms, physiological significance and antisense targeting.
Advances in experimental medicine and biology 1995;395():173-83.
1994: Thomas Skutella; JC Probst; Mario Engelmann; Carsten T Wotjak; Rainer Landgraf; G F Jirikowski
Vasopressin antisense oligonucleotide induces temporary diabetes insipidus in rats.
Journal of neuroendocrinology 1994;6(6):626.
1994: Thomas Skutella; Alexandra Montkowski; Thomas Stoehr; JC Probst; Rainer Landgraf; Florian Holsboer; G F Jirikowski
Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats.
Cellular and molecular neurobiology 1994;14(5):579-88.
1994: Mario Engelmann; Carsten T Wotjak; Rainer Landgraf
Direct osmotic stimulation of the hypothalamic paraventricular nucleus by microdialysis induces excessive grooming in the rat.
Behavioural brain research 1994;63(2):221-5.
1994: G Munro; M Ludwig; Rainer Landgraf; John A Russell
Opioids influence neurohypophysial but not central oxytocin release following direct hyperosmotic stimulation of the supraoptic nucleus in urethane-anaesthetised rats.
Neuropeptides 1994;27(2):121-7.
1994: Carsten T Wotjak; M Ludwig; Rainer Landgraf
Vasopressin facilitates its own release within the rat supraoptic nucleus in vivo.
Neuroreport 1994;5(10):1181-4.
1994: Thomas Skutella; JC Probst; Mario Engelmann; Carsten T Wotjak; Rainer Landgraf; G F Jirikowski
Vasopressin antisense oligonucleotide induces temporary diabetes insipidus in rats.
Journal of neuroendocrinology 1994;6(2):121-5.
1992: John A Russell; I Neumann; Rainer Landgraf
Oxytocin and vasopressin release in discrete brain areas after naloxone in morphine-tolerant and -dependent anesthetized rats: push-pull perfusion study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(3):1024-32.