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Luisa Lanfrancone

Research Profile

Chemicals & Drugs

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Mouse

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Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Physiology

Signal Transduction

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Cloning, Molecular

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Publications

TOP 3
Ewa Aladowicz; Leda Ferro; Lorenzo Fornasari; Elisabetta Venditti; Giulio Cesare Vitali; Luisa Lanfrancone
Molecular networks in melanoma invasion and metastasis.
Margherita Y Turco; Simona Ronzoni; Anna Sciullo; Antonio Simeone; Daniel Constam; Anja Dietze; Mario Faretta; Luis Fernandez Diaz; Laura Furia; Luisa Lanfrancone
Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Roberta Bosotti; Raffaele Calogero; Paolo Cappella; Patrizia Carpinelli; Sandra Healy; Luisa Lanfrancone; Giuseppe Locatelli; Jurgen Moll; Antonella Isacchi
Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.

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All Publications

2013: Ewa Aladowicz; Leda Ferro; Lorenzo Fornasari; Elisabetta Venditti; Giulio Cesare Vitali; Luisa Lanfrancone
Molecular networks in melanoma invasion and metastasis.
Future oncology (London, England) 2013;9(5):713-26.
2012: Margherita Y Turco; Simona Ronzoni; Anna Sciullo; Antonio Simeone; Daniel Constam; Anja Dietze; Mario Faretta; Luis Fernandez Diaz; Laura Furia; Luisa Lanfrancone
Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Stem cells (Dayton, Ohio) 2012;30(11):2423-36.
2012: Roberta Bosotti; Raffaele Calogero; Paolo Cappella; Patrizia Carpinelli; Sandra Healy; Luisa Lanfrancone; Giuseppe Locatelli; Jurgen Moll; Antonella Isacchi
Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.
Gene 2012;494(2):202-8.
2011: Silvia Licciulli; Chiara Luise; Gaia Scafetta; Maria Capra; Giuseppina Giardina; Paolo Giovanni Nuciforo; Silvano Bosari; Giuseppe Viale; Giovanni Mazzarol; Chiara Tonelli; Luisa Lanfrancone; Myriam Alcalay
Pirin inhibits cellular senescence in melanocytic cells.
The American journal of pathology 2011;178(5):2397-406.
2010: Silvia Licciulli; Chiara Luise; Andrea Zanardi; Luca Giorgetti; Giuseppe Viale; Luisa Lanfrancone; Roberta Carbone; Myriam Alcalay
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.
BMC cell biology 2010;11():5.
2009: Cristina Santoriello; Gianluca Deflorian; Federica Pezzimenti; Koichi Kawakami; Luisa Lanfrancone; Fabrizio d'Adda di Fagagna; Marina Mione
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Disease models & mechanisms 2009;2(1-2):56-67.
2008: Mercedes Rodriguez; Ewa Aladowicz; Luisa Lanfrancone; Colin R Goding
Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.
Cancer research 2008;68(19):7872-81.
2008: Francesca Finetti; Michela Pellegrini; Cristina Ulivieri; Maria Teresa Savino; Eugenio Paccagnini; Chiara Ginanneschi; Luisa Lanfrancone; Pier Giuseppe Pelicci; Cosima T Baldari
The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
Blood 2008;111(10):5017-27.
2007: Laura Patrussi; Cristina Ulivieri; Orso Maria Lucherini; Silvia Rossi Paccani; Alessandra Gamberucci; Luisa Lanfrancone; Pier Giuseppe Pelicci; Cosima T Baldari
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
Blood 2007;110(6):1730-8.
2007: Ernesta Fagiani; Giuseppina Giardina; Lucilla Luzi; matteo cesaroni; Micaela Quarto; Maria Capra; Giovanni Germano; Maria Bono; Manuela Capillo; Pier Giuseppe Pelicci; Luisa Lanfrancone
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
Cancer research 2007;67(7):3064-73.
2005: Gallia Graiani; Costanza Lagrasta; Enrica Migliaccio; Frank Spillmann; Marco Meloni; Paolo Madeddu; Federico Quaini; Ines Martin Padura; Luisa Lanfrancone; Pier Giuseppe Pelicci; Costanza Emanueli
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Hypertension 2005;46(2):433-40.
2005: Laura Patrussi; Maria Teresa Savino; Michela Pellegrini; Silvia Rossi Paccani; Enrica Migliaccio; Simon Plyte; Luisa Lanfrancone; Pier Giuseppe Pelicci; Cosima T Baldari
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Oncogene 2005;24(13):2218-28.
2004: Francesca Orsini; Enrica Migliaccio; Maurizio Moroni; Cristina Contursi; Veronica A Raker; Daniele Piccini; Ines Martin-Padura; Giovanni Pelliccia; Mirella Trinei; Maria Bono; Claudia Puri; Carlo Tacchetti; Monica Ferrini; Roberta Mannucci; Ildo Nicoletti; Luisa Lanfrancone; Marco Giorgio; Pier Giuseppe Pelicci
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
The Journal of biological chemistry 2004;279(24):25689-95.
2004: Enrica Audero; Ilaria Cascone; Fabrizio Maniero; Lucia Napione; Marco Arese; Luisa Lanfrancone; Federico Bussolino
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
The Journal of biological chemistry 2004;279(13):13224-33.
2004: Sonia Pacini; Michela Pellegrini; Enrica Migliaccio; Laura Patrussi; Cristina Ulivieri; Andrea Ventura; Fabio Carraro; Antonella Naldini; Luisa Lanfrancone; Pier Giuseppe Pelicci; Cosima T Baldari
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Molecular and cellular biology 2004;24(4):1747-57.
2002: Mirella Trinei; Marco Giorgio; Angelo Cicalese; Sara Barozzi; Andrea Ventura; Enrica Migliaccio; Elisabetta Milia; Ines Martin Padura; Veronica A Raker; Marco Maccarana; Valeria Petronilli; Saverio Minucci; Paolo Bernardi; Luisa Lanfrancone; Pier Giuseppe Pelicci
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Oncogene 2002;21(24):3872-8.
2002: Adriana Zanetti; Maria Grazia Lampugnani; Giovanna Balconi; Ferruccio Breviario; Monica Corada; Luisa Lanfrancone; Elisabetta Dejana
Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):617-22.
2001: Ricciarda Galandrini; Ilaria Tassi; Stefania Morrone; Luisa Lanfrancone; Pier Giuseppe Pelicci; Mario Piccoli; Luigi Frati; Angela Santoni
The adaptor protein shc is involved in the negative regulation of NK cell-mediated cytotoxicity.
European journal of immunology 2001;31(7):2016-25.
2000: Luca Primo; Cristina Roca; Chiara Ferrandi; Luisa Lanfrancone; Federico Bussolino
Human endothelial cells expressing polyoma middle T induce tumors.
Oncogene 2000;19(32):3632-41.
2000: Simon Plyte; M Bernardetta Majolini; Sonia Pacini; F Scarpini; C Bianchini; Luisa Lanfrancone; Pier Giuseppe Pelicci; Cosima T Baldari
Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts.
Oncogene 2000;19(12):1529-37.
2000: Mirella Trinei; Luisa Lanfrancone; E Campo; Karen Pulford; D Y Mason; Pier Giuseppe Pelicci; Brunangelo Falini
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Cancer research 2000;60(4):793-8.
1999: Enrica Migliaccio; Marco Giorgio; S Mele; Giuliana Pelicci; P Reboldi; P P Pandolfi; Luisa Lanfrancone; Pier Giuseppe Pelicci
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Nature 1999;402(6759):309-13.
1998: Maria Felice Brizzi; Arturo Rosso; Patrizia Dentelli; Dario Ferrero; Luisa Lanfrancone; Luigi Pegoraro
c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells.
Experimental hematology 1998;26(13):1229-39.
1998: Sonia Pacini; Cristina Ulivieri; MM Di Somma; A Isacchi; Luisa Lanfrancone; Pier Giuseppe Pelicci; John L Telford; Cosima T Baldari
Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
The Journal of biological chemistry 1998;273(32):20487-93.
1997: Luciana Dente; C Vetriani; Adriana Zucconi; Giuliana Pelicci; Luisa Lanfrancone; Pier Giuseppe Pelicci; Gianni Cesareni
Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides.
Journal of molecular biology 1997;269(5):694-703.
1997: Enrica Migliaccio; S Mele; Anna Elisabetta Salcini; Giuliana Pelicci; K M Lai; G Superti-Furga; T Pawson; Pier Paolo Di Fiore; Luisa Lanfrancone; Pier Giuseppe Pelicci
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
The EMBO journal 1997;16(4):706-16.
1996: Maria Felice Brizzi; Patrizia Dentelli; Luisa Lanfrancone; Arturo Rosso; P G Pelicci; Luigi Pegoraro
Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPO-mediated myeloid cell proliferation.
Oncogene 1996;13(10):2067-76.
1996: E Milia; MM Di Somma; F Baldoni; R Chiari; Luisa Lanfrancone; Pier Giuseppe Pelicci; John L Telford; Cosima T Baldari
The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation.
Oncogene 1996;13(4):767-75.
1996: L Bonfini; Enrica Migliaccio; Giuliana Pelicci; Luisa Lanfrancone; Pier Giuseppe Pelicci
Not all Shc's roads lead to Ras.
Trends in biochemical sciences 1996;21(7):257-61.
1996: Lavinia V Lotti; Luisa Lanfrancone; Enrica Migliaccio; Claudia Zompetta; Giuliana Pelicci; Anna Elisabetta Salcini; B Falini; Pier Giuseppe Pelicci; Maria Rosaria Torrisi
Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.
Molecular and cellular biology 1996;16(5):1946-54.
1996: C Tribioli; S Droetto; Silvia Bione; Gianni Cesareni; Maria Rosaria Torrisi; Lavinia V Lotti; Luisa Lanfrancone; Daniela Toniolo; Pier Giuseppe Pelicci
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):695-9.
1995: A Ricci; Luisa Lanfrancone; R Chiari; G Belardo; C Pertica; Pier Giorgio Natali; Pier Giuseppe Pelicci; O Segatto
Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.
Oncogene 1995;11(8):1519-29.
1995: Giuliana Pelicci; Luisa Lanfrancone; Anna Elisabetta Salcini; A Romano; S Mele; M Grazia Borrello; O Segatto; Pier Paolo Di Fiore; Pier Giuseppe Pelicci
Constitutive phosphorylation of Shc proteins in human tumors.
Oncogene 1995;11(5):899-907.
1995: Giuliana Pelicci; silvia giordano; Z Zhen; Anna Elisabetta Salcini; Luisa Lanfrancone; Alberto Bardelli; G Panayotou; Michael D Waterfield; Carola Ponzetto; Pier Giuseppe Pelicci
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
Oncogene 1995;10(8):1631-8.
1995: Luisa Lanfrancone; Giuliana Pelicci; Maria Felice Brizzi; M G Aronica; C Casciari; S Giuli; Luigi Pegoraro; Tony Pawson; Pier Giuseppe Pelicci; M G Arouica
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.
Oncogene 1995;10(5):907-17.
1994: F Re; Adriana Zanetti; M Sironi; N Polentarutti; Luisa Lanfrancone; Elisabetta Dejana; F Colotta
Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.
The Journal of cell biology 1994;127(2):537-46.
1994: Kay Huebner; K Kastury; Teresa Druck; Anna Elisabetta Salcini; Luisa Lanfrancone; Giuliana Pelicci; E Lowenstein; W Li; S H Park; Linda Cannizzaro
Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).
Genomics 1994;22(2):281-7.
1994: Luisa Lanfrancone; Giuliana Pelicci; P G Pelicci
Cancer genetics.
Current opinion in genetics & development 1994;4(1):109-19.
1994: Stephen M Dilworth; C E Brewster; M D Jones; Luisa Lanfrancone; Giuliana Pelicci; P G Pelicci
Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.
Nature 1994;367(6458):87-90.
1993: Kay Huebner; Teresa Druck; S LaForgia; J Lasota; Carlo M Croce; Luisa Lanfrancone; Emilio Donti; G Pengue; Girolama La Mantia; Pier Giuseppe Pelicci
Chromosomal localization of four human zinc finger cDNAs.
Human genetics 1993;91(3):217-22.
1992: N Jonjić; Giuseppe Peri; Sergio Bernasconi; F L Sciacca; F Colotta; P Pelicci; Luisa Lanfrancone; A Mantovani
Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.
The Journal of experimental medicine 1992;176(4):1165-74.
1992: Giuliana Pelicci; Luisa Lanfrancone; F Grignani; J McGlade; F Cavallo; G Forni; Ildo Nicoletti; Francesco Grignani; Tony Pawson; Pier Giuseppe Pelicci
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Cell 1992;70(1):93-104.
1992: Luisa Lanfrancone; G Pengue; Pier Paolo Pandolfi; Anna Elisabetta Salcini; A Giacomucci; L Longo; Emilio Donti; P De Luca; Girolama La Mantia; Pier Giuseppe Pelicci
Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.
Genomics 1992;12(4):720-8.
1992: Elisabetta Blasi; Lucia Pitzurra; Manuela Puliti; Luisa Lanfrancone; Francesco Bistoni
Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans.
Infection and immunity 1992;60(3):832-7.
1991: Emilio Donti; Luisa Lanfrancone; P G Pelicci; G D Birnie; Riccardo Dalla-Favera
Loss of amplification and appearance of a novel translocation site of the c-myc oncogene in HL-60 leukemia cells.
Cancer genetics and cytogenetics 1991;56(1):57-64.
1991: Girolama La Mantia; Domenico Maglione; G Pengue; Antonio Di Cristofano; A Simeone; Luisa Lanfrancone; Luigi Lania
Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.
Nucleic acids research 1991;19(7):1513-20.
1990: Roberto Gerli; A Bertotto; Elisabetta Agea; Luisa Lanfrancone; C Cernetti; Fabrizio Spinozzi; P Rambotti
Basis for defective proliferation of peripheral blood T cells to anti-CD2 antibodies in primary Sjögren's syndrome.
The Journal of clinical investigation 1990;86(6):1870-7.
1990: Giuliana Pelicci; M C Pagliacci; Luisa Lanfrancone; P G Pelicci; Francesco Grignani; Ildo Nicoletti
Inhibitory effect of the somatostatin analog octreotide on rat pituitary tumor cell (GH3) proliferation in vitro.
Journal of endocrinological investigation 1990;13(8):657-62.
1990: A Bertotto; Roberto Gerli; Luisa Lanfrancone; S Crupi; C Arcangeli; C Cernetti; Fabrizio Spinozzi; P Rambotti
Activation of cord T lymphocytes. II. Cellular and molecular analysis of the defective response induced by anti-CD3 monoclonal antibody.
Cellular immunology 1990;127(2):247-59.
1990: Emilio Donti; Luisa Lanfrancone; Kay Huebner; A Pascucci; Giovanna Venti; G Pengue; Francesco Grignani; C M Croce; Luigi Lania; Pier Giuseppe Pelicci
Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers.
Human genetics 1990;84(5):391-5.
1990: Myriam Alcalay; F Antolini; W J Van de Ven; Luisa Lanfrancone; Francesco Grignani; Pier Giuseppe Pelicci
Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.
Oncogene 1990;5(3):267-75.
1990: Luigi Lania; Emilio Donti; Antonio Pannuti; A Pascucci; G Pengue; Isidoro Feliciello; Girolama La Mantia; Luisa Lanfrancone; Pier Giuseppe Pelicci
cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes.
Genomics 1990;6(2):333-40.
1990: Corrado Tarella; Patrizia Pregno; E Gallo; Daniele Caracciolo; S Stefani; C Barletta; Luisa Lanfrancone; Dario Ferrero
Establishment from an adult leukemic patient of two novel precursor B cell lines with different growth modality.
Leukemia research 1990;14(2):177-84.
1989: B Falini; L Flenghi; Marta Fagioli; H Stein; R Schwarting; C Riccardi; I Manocchio; S Pileri; P G Pelicci; Luisa Lanfrancone
Evolutionary conservation in various mammalian species of the human proliferation-associated epitope recognized by the Ki-67 monoclonal antibody.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(10):1471-8.
1988: Antonio Pannuti; Luisa Lanfrancone; A Pascucci; Pier Giuseppe Pelicci; Girolama La Mantia; Luigi Lania
Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.
Nucleic acids research 1988;16(10):4227-37.
1985: Luisa Lanfrancone; Dario Ferrero; E Gallo; R Foa; Corrado Tarella
Release of hemopoietic factors by normal human T cell lines with either suppressor or helper activity.
Journal of cellular physiology 1985;122(1):7-13.
1983: Dario Ferrero; E Gallo; Luisa Lanfrancone; C Tarella
Functional and phenotypic characterization of two HL60 clones resistant to dimethylsulfoxide.
Experimental cell research 1983;147(1):111-8.