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Wallace Langdon

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Samuel J Taylor; Christine B F Thien; Matthew E Wikstrom; Samantha A Dagger; Wallace Y Langdon
Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling.
Hui Guo; Wallace Y Langdon; Zhenping Li; Yanran Liang; Stanley Lipkowitz; Josef M Penninger; Guilin Qiao; Lifen Yang; Haiyan Ying; Yixia Zhao; Jian Zhang
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
Wallace Y Langdon
FLT3 signaling and the development of inhibitors that target FLT3 kinase activity.

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All Publications

2012: Samuel J Taylor; Christine B F Thien; Matthew E Wikstrom; Samantha A Dagger; Wallace Y Langdon
Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling.
Blood 2012;120(19):4049-57.
2012: Hui Guo; Wallace Y Langdon; Zhenping Li; Yanran Liang; Stanley Lipkowitz; Josef M Penninger; Guilin Qiao; Lifen Yang; Haiyan Ying; Yixia Zhao; Jian Zhang
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
Cell reports 2012;1(5):472-82.
2012: Wallace Y Langdon
FLT3 signaling and the development of inhibitors that target FLT3 kinase activity.
Critical reviews in oncogenesis 2012;17(2):199-209.
2011: Lorena Buitrago; Wallace Y Langdon; Archana Sanjay; Satya P Kunapuli
Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling.
Blood 2011;118(20):5631-40.
2011: Reza Ghassemifar; Christine B F Thien; Jill Finlayson; David Joske; Gavin M Cull; Bradley Augustson; Wallace Y Langdon
Incidence of c-Cbl mutations in human acute myeloid leukaemias in an Australian patient cohort.
Pathology 2011;43(3):261-5.
2011: Magdalena Paolino; Christine B F Thien; Thomas Gruber; Reinhard Hinterleitner; Gottfried Baier; Wallace Y Langdon; Josef M Penninger
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2138-47.
2011: Gerard F Hoyne; Eleanor Flening; Mehmet Yabas; Charis Teh; John A Altin; Katrina Randall; Christine B F Thien; Wallace Y Langdon; Christopher C Goodnow
Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2024-32.
2010: Naga Suresh Adapala; Mary F Barbe; Wallace Y Langdon; Mary C Nakamura; Alexander Y Tsygankov; Archana Sanjay
The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.
The Journal of biological chemistry 2010;285(47):36745-58.
2010: Chozhavendan Rathinam; Christine B F Thien; Richard A Flavell; Wallace Y Langdon
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
Cancer cell 2010;18(4):341-52.
2010: James L Daniel; Carol A Dangelmaier; Sripal Mada; Lorena Buitrago; Jianguo Jin; Wallace Y Langdon; Alexander Y Tsygankov; Satya P Kunapuli; Archana Sanjay
Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.
The Journal of biological chemistry 2010;285(23):17282-91.
2010: Christine B F Thien; Samantha A Dagger; James H Steer; Frank Koentgen; Elisa S Jansen; Clare L Scott; Wallace Y Langdon
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.
The Journal of biological chemistry 2010;285(14):10969-81.
2010: Naga Suresh Adapala; Mary F Barbe; Wallace Y Langdon; Alexander Y Tsygankov; Archana Sanjay
Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization.
Annals of the New York Academy of Sciences 2010;1192():376-84.
2010: Alusha A Mamchak; Christine B F Thien; Samantha A Dagger; Julia Lyandres; Shuwei Jiang; Wallace Y Langdon; Anthony L DeFranco
Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.
European journal of immunology 2010;40(2):539-47.
2009: Satoshi Kojo; Chris Elly; Yohsuke Harada; Wallace Y Langdon; Mitchell Kronenberg; Yun-Cai Liu
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17847-51.
2009: Manikuntala Kundu; Sushil Kumar Pathak; Kuldeep Kumawat; Sanchita Basu; Gargi Chatterjee; Shresh Pathak; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo; Christine B F Thien; Wallace Y Langdon; Joyoti Basu
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Nature immunology 2009;10(8):918-26.
2008: Chozhavendan Rathinam; Christine B F Thien; Wallace Y Langdon; Hua Gu; Richard A Flavell
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Genes & development 2008;22(8):992-7.
2008: Morten P Oksvold; Samantha A Dagger; Christine B F Thien; Wallace Y Langdon
The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.
Molecular immunology 2008;45(4):925-36.
2006: Juan Carlos Molero; Nigel Turner; Christine B F Thien; Wallace Y Langdon; David E James; Gregory J Cooney
Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action.
Diabetes 2006;55(12):3411-7.
2006: Sonja E Gustin; Christine B F Thien; Wallace Y Langdon
Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5980-9.
2005: Christine B F Thien; Frøydis D Blystad; Yifan Zhan; Andrew M Lew; Valentina Voigt; Christopher Andoniou; Wallace Y Langdon
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.
The EMBO journal 2005;24(21):3807-19.
2005: Christine B F Thien; Wallace Y Langdon
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
The Biochemical journal 2005;391(Pt 2):153-66.
2005: Christine B F Thien; Wallace Y Langdon
Negative regulation of PTK signalling by Cbl proteins.
Growth factors (Chur, Switzerland) 2005;23(2):161-7.
2004: Juan Carlos Molero; Thomas E Jensen; Phil C Withers; Michelle Couzens; Herbert Herzog; Christine B F Thien; Wallace Y Langdon; Ken Walder; Maria A Murphy; David D L Bowtell; David E James; Gregory J Cooney
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.
The Journal of clinical investigation 2004;114(9):1326-33.
2004: Morten P Oksvold; Henrik S Huitfeldt; Wallace Y Langdon
Identification of 14-3-3zeta as an EGF receptor interacting protein.
FEBS letters 2004;569(1-3):207-10.
2004: Morten P Oksvold; Christine B F Thien; Jannicke Widerberg; Andrew Chantry; Henrik S Huitfeldt; Wallace Y Langdon
UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain.
Radiation research 2004;161(6):685-91.
2003: Morten P Oksvold; Christine B F Thien; Jannicke Widerberg; Andrew Chantry; Henrik S Huitfeldt; Wallace Y Langdon
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
Oncogene 2003;22(52):8509-18.
2003: Robin M Scaife; Didier Job; Wallace Y Langdon
Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl.
Molecular biology of the cell 2003;14(11):4605-17.
2003: Christine B F Thien; Robin M Scaife; John M Papadimitriou; Maria A Murphy; David D L Bowtell; Wallace Y Langdon
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
The Journal of experimental medicine 2003;197(4):503-13.
2003: Robin M Scaife; Sara A Courtneidge; Wallace Y Langdon
The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.
Journal of cell science 2003;116(Pt 3):463-73.
2002: Esther Sook Miin Wong; Chee Wai Fong; Jormay Lim; Permeen Yusoff; Boon Chuan Low; Wallace Y Langdon; Graeme R Guy
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.
The EMBO journal 2002;21(18):4796-808.
2002: Philippe Soubeyran; Katarzyna Kowanetz; Iwona Pilecka; Wallace Y Langdon; Ivan Dikic
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
Nature 2002;416(6877):183-7.
2001: Pascal Peschard; TM Fournier; Louie Lamorte; Monica A Naujokas; Hamid Band; Wallace Y Langdon; Morag Park
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.
Molecular cell 2001;8(5):995-1004.
2001: Christine B F Thien; Wallace Y Langdon
Cbl: many adaptations to regulate protein tyrosine kinases.
Nature reviews. Molecular cell biology 2001;2(4):294-307.
2001: Christine B F Thien; F Walker; Wallace Y Langdon
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
Molecular cell 2001;7(2):355-65.
2000: TM Fournier; Louie Lamorte; Christiane R Maroun; ML Lupher; Hamid Band; Wallace Y Langdon; Morag Park
Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion.
Molecular biology of the cell 2000;11(10):3397-410.
2000: Christopher Andoniou; Nancy L. Lill; Christine B F Thien; ML Lupher; S Ota; David D L Bowtell; Robin M Scaife; Wallace Y Langdon; Hamid Band
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
Molecular and cellular biology 2000;20(3):851-67.
2000: Robin M Scaife; Wallace Y Langdon
c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology.
Journal of cell science 2000;113 Pt 2():215-26.
1999: Christine B F Thien; David D L Bowtell; Wallace Y Langdon
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7133-9.
1998: Christine B F Thien; Wallace Y Langdon
c-Cbl: a regulator of T cell receptor-mediated signalling.
Immunology and cell biology 1998;76(5):473-82.
1998: Maria A Murphy; R G Schnall; Deon J Venter; L Barnett; Ivan Bertoncello; Christine B F Thien; Wallace Y Langdon; David D L Bowtell
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice.
Molecular and cellular biology 1998;18(8):4872-82.
1997: Christine B F Thien; Wallace Y Langdon
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl.
Oncogene 1997;15(24):2909-19.
1997: H Robertson; Wallace Y Langdon; Christine B F Thien; David D L Bowtell
A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components.
Biochemical and biophysical research communications 1997;240(1):46-50.
1997: D P Bonita; Sachiko Miyake; ML Lupher; Wallace Y Langdon; Hamid Band
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.
Molecular and cellular biology 1997;17(8):4597-610.
1997: Christine B F Thien; Wallace Y Langdon
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene.
Oncogene 1997;14(18):2239-49.
1996: Christopher Andoniou; Christine B F Thien; Wallace Y Langdon
The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.
Oncogene 1996;12(9):1981-9.
1995: Wallace Y Langdon
The cbl oncogene: a novel substrate of protein tyrosine kinases.
Australian and New Zealand journal of medicine 1995;25(6):859-64.
1995: David D L Bowtell; Wallace Y Langdon
The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.
Oncogene 1995;11(8):1561-7.
1994: Christopher Andoniou; Christine B F Thien; Wallace Y Langdon
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.
The EMBO journal 1994;13(19):4515-23.