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Roger Adan

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TOP 3
Roger A H Adan
Mechanisms underlying current and future anti-obesity drugs.
Arjen J Boender; Andrea J van Rozen; Roger A H Adan
Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.
Frank J Meye; Marten P Smidt; Ruud van Zessen; Roger A H Adan; Geert M J Ramakers
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.

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All Publications

2013: Roger A H Adan
Mechanisms underlying current and future anti-obesity drugs.
Trends in neurosciences 2013;36(2):133-40.
2012: Arjen J Boender; Andrea J van Rozen; Roger A H Adan
Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.
Obesity (Silver Spring, Md.) 2012;20(12):2420-5.
2012: Frank J Meye; Marten P Smidt; Ruud van Zessen; Roger A H Adan; Geert M J Ramakers
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(46):16120-8.
2012: Unna N Danner; Hans W Hoek; Nicole Sanders; Paul A M Smeets; Roger A H Adan; Floor van Meer; Annemarie A Van Elburg
Neuropsychological weaknesses in anorexia nervosa: set-shifting, central coherence, and decision making in currently ill and recovered women.
The International journal of eating disorders 2012;45(5):685-94.
2012: Marek K Brandys; Martien J H Kas; JIMMY MOLYNEUX; Christel M Middeldorp; Roel A Ophoff; Eline Slagboom; Margarita C T Slof-Op't Landt; Annemarie A Van Elburg; Eric F van Furth; Willem Verduijn; Dorret I Boomsma; Roger A H Adan
Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.
Psychiatric genetics 2012;22(3):130-6.
2012: Myrte Merkestein; Maike A D Brans; Johannes W de Jong; Suzanne L Dickson; Emil Egecioglu; Mieneke C M Luijendijk; Roger A H Adan
Ghrelin mediates anticipation to a palatable meal in rats.
Obesity (Silver Spring, Md.) 2012;20(5):963-71.
2012: Sebastian Cardona Cano; Suzanne L Dickson; Myrte Merkestein; Karolina P Skibicka; Roger A H Adan
Role of ghrelin in the pathophysiology of eating disorders: implications for pharmacotherapy.
CNS drugs 2012;26(4):281-96.
2012: Esther M van der Zwaal; Louk J M J Vanderschuren; Mieneke C M Luijendijk; Roger A H Adan; Roxana Baclesanu; Sanna K Janhunen; Susanne E La Fleur
Olanzapine and sibutramine have opposing effects on the motivation for palatable food.
Behavioural pharmacology 2012;23(2):198-204.
2012: Joram D Mul; Pim W Toonen; Ruben van Boxtel; Keith M Garner; Roger A H Adan; Dylan J M Bergen; Jan H Brakkee; Maike A D Brans; Edwin Cuppen
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.
Obesity (Silver Spring, Md.) 2012;20(3):612-21.
2012: Annemarie A Van Elburg; Jacquelien J G Hillebrand; Hans W Hoek; Chaim Huyser; Martien J H Kas; Maartje Snoek; Roger A H Adan
Mandometer treatment not superior to treatment as usual for anorexia nervosa.
The International journal of eating disorders 2012;45(2):193-201.
2012: E M van der Zwaal; E R Verheij; L I H Bok; M A D Brans; Susanne E La Fleur; Y K Lam; Mieneke C M Luijendijk; M Merkestein; Roger A H Adan
The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature.
International journal of obesity (2005) 2012;36(2):254-61.
2012: Olaia Carrera; Unna N Danner; Emilio Gutierrez; Hans W Hoek; Roger A H Adan; Annemarie A Van Elburg; Martien J H Kas
Hyperactivity in anorexia nervosa: warming up not just burning-off calories.
PloS one 2012;7(7):e41851.
2011: Linda A W Verhagen; Linda P G van Dommelen; Roger A H Adan; Jan-Willem de Groot; Anne G Klimstra; Mieneke C M Luijendijk; Tom A P Roeling
Anticipation of meals during restricted feeding increases activity in the hypothalamus in rats.
The European journal of neuroscience 2011;34(9):1485-91.
2011: Sanna K Janhunen; Susanne E La Fleur; Esther M van der Zwaal; Roger A H Adan
Inverse agonism at α2A adrenoceptors augments the hypophagic effect of sibutramine in rats.
Obesity (Silver Spring, Md.) 2011;19(10):1979-86.
2011: Marek K Brandys; Iain C Campbell; Martien J H Kas; Annemarie A Van Elburg; Roger A H Adan
A meta-analysis of circulating BDNF concentrations in anorexia nervosa.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2011;12(6):444-54.
2011: Rahul Pandit; Johannes W de Jong; Louk J M J Vanderschuren; Roger A H Adan
Neurobiology of overeating and obesity: the role of melanocortins and beyond.
European journal of pharmacology 2011;660(1):28-42.
2011: Andrew Ternouth; Marek K Brandys; Yvonne T van der Schouw; Judith Hendriks; John-Olov Jansson; David Collier; Roger A H Adan
Association study of POMC variants with body composition measures and nutrient choice.
European journal of pharmacology 2011;660(1):220-5.
2011: Marijke W A de Backer; Susanne E La Fleur; Roger A H Adan
Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner.
European journal of pharmacology 2011;660(1):148-55.
2011: José K van den Heuvel; Andréa J van Rozen; Roger A H Adan; Susanne E La Fleur
An overview on how components of the melanocortin system respond to different high energy diets.
European journal of pharmacology 2011;660(1):207-12.
2011: M W A de Backer; Susanne E La Fleur; M A D Brans; A J van Rozen; Mieneke C M Luijendijk; M Merkestein; Keith M Garner; E M van der Zwaal; Roger A H Adan
Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions.
International journal of obesity (2005) 2011;35(5):629-41.
2011: Linda A W Verhagen; Emil Egecioglu; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan; Suzanne L Dickson
Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2011;21(5):384-92.
2011: Linda A W Verhagen; Mieneke C M Luijendijk; Roger A H Adan
Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2011;21(3):274-81.
2011: Linda van den Berg; Olivier van Beekum; Peter Heutink; Bram A Felius; Monique P M van de Heijning; Stefan Strijbis; Rosalina Spaendonk; Daniela Piancatelli; Keith M Garner; Rajae El Aouad; Erik Sistermans; Roger A H Adan; Henriette A Delemarre-Van De Waal
Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children.
Obesity (Silver Spring, Md.) 2011;19(3):604-11.
2011: Marijke W A de Backer; Keith M Garner; Mieneke C M Luijendijk; Roger A H Adan
Recombinant adeno-associated viral vectors.
Methods in molecular biology (Clifton, N.J.) 2011;789():357-76.
2011: Joram D Mul; Susanne E La Fleur; Pim W Toonen; Anthonieke Afrasiab-Middelman; Rob Binnekade; Dustin Schetters; Michel M M Verheij; Robert M Sears; Judith R Homberg; Anton N M Schoffelmeer; Roger A H Adan; Ralph J DiLeone; Taco J De Vries; Edwin Cuppen
Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat.
PloS one 2011;6(5):e19600.
2011: Roger A H Adan; Jacquelien J G Hillebrand; U N Danner; Martien J H Kas; S Cardona Cano; L A W Verhagen
Neurobiology driving hyperactivity in activity-based anorexia.
Current topics in behavioral neurosciences 2011;6():229-50.
2011: Martien J H Kas; Roger A H Adan
Animal models of eating disorder traits.
Current topics in behavioral neurosciences 2011;6():209-27.
2010: M W A de Backer; M A D Brans; A J van Rozen; E M van der Zwaal; Mieneke C M Luijendijk; K G Garner; M de Krom; O van Beekum; Susanne E La Fleur; Roger A H Adan
Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance.
Journal of molecular endocrinology 2010;45(5):341-53.
2010: Esther M van der Zwaal; Mieneke C M Luijendijk; Simon S Evers; Susanne E La Fleur; Roger A H Adan
Olanzapine affects locomotor activity and meal size in male rats.
Pharmacology, biochemistry, and behavior 2010;97(1):130-7.
2010: Marijke W A de Backer; Maike A D Brans; Mieneke C M Luijendijk; Keith M Garner; Roger A H Adan
Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus.
Human gene therapy 2010;21(6):673-82.
2010: Marek K Brandys; Annemarie A van Elburg; Ruth J F Loos; Florianne Bauer; Judith Hendriks; Yvonne van der Schouw; Roger A H Adan
Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(2):695-9.
2010: Susanne E La Fleur; A J van Rozen; Mieneke C M Luijendijk; F Groeneweg; Roger A H Adan
A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia.
International journal of obesity (2005) 2010;34(3):537-46.
2010: Marijke W A de Backer; Maike A D Brans; Mieneke C M Luijendijk; Keith M Garner; Dianne M A van den Heuvel; R Jeroen Pasterkamp; Roger A H Adan
Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.
BMC neuroscience 2010;11():94.
2009: Florianne Bauer; Clara C Elbers; Roger A H Adan; Ruth Jf Loos; N Charlotte Onland-Moret; Diederick Grobbee; Jana V van Vliet-Ostaptchouk; Cisca Wijmenga; Yvonne van der Schouw
Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.
The American journal of clinical nutrition 2009;90(4):951-9.
2009: Birgitte Tiesjema; Susanne E La Fleur; Mieneke C M Luijendijk; Roger A H Adan
Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.
Obesity (Silver Spring, Md.) 2009;17(7):1448-50.
2009: Linda A W Verhagen; Mieneke C M Luijendijk; Gerdien A H Korte-Bouws; S Mechiel Korte; Roger A H Adan
Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2009;19(5):309-16.
2009: Linda A W Verhagen; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan
Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2009;19(3):153-60.
2009: A F Maarten Altelaar; shabaz mohammed; Maike A D Brans; Roger A H Adan; Albert J R Heck
Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis.
Journal of proteome research 2009;8(2):870-6.
2009: Mariken de Krom; Florianne Bauer; David Collier; Roger A H Adan; Susanne E La Fleur
Genetic variation and effects on human eating behavior.
Annual review of nutrition 2009;29():283-304.
2008: Jacquelien J G Hillebrand; Martien J H Kas; A A van Elburg; Hans W Hoek; Roger A H Adan
Leptin's effect on hyperactivity: potential downstream effector mechanisms.
Physiology & behavior 2008;94(5):689-95.
2008: Floor Remmers; Linda A W Verhagen; Roger A H Adan; Henriette A Delemarre-Van De Waal
Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction.
Endocrinology 2008;149(7):3617-25.
2008: Esther M van der Zwaal; Mieneke C M Luijendijk; Roger A H Adan; Susanne E La Fleur
Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution.
European journal of pharmacology 2008;585(1):130-6.
2008: Birgitte Tiesjema; Myrte Merkestein; Keith M Garner; Mariken de Krom; Roger A H Adan
Multimeric alpha-MSH has increased efficacy to activate the melanocortin MC4 receptor.
European journal of pharmacology 2008;585(1):24-30.
2008: Annet F M van Abeelen; Mariken de Krom; Judith Hendriks; Diederick Grobbee; Roger A H Adan; Yvonne van der Schouw
Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(5):669-76.
2008: Roger A H Adan; Louk J M J Vanderschuren; Susanne E la Fleur
Anti-obesity drugs and neural circuits of feeding.
Trends in pharmacological sciences 2008;29(4):208-17.
2007: Birgitte Tiesjema; Roger A H Adan; Mieneke C M Luijendijk; Andries Kalsbeek; Susanne E La Fleur
Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(51):14139-46.
2007: Birgitte Tiesjema; Susanne E La Fleur; Mieneke C M Luijendijk; Maike A D Brans; En-Ju Lin; Matthew J During; Roger A H Adan
Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity.
Obesity (Silver Spring, Md.) 2007;15(10):2424-35.
2007: Susanne E La Fleur; Louk J M J Vanderschuren; Mieneke C M Luijendijk; B M Kloeze; Birgitte Tiesjema; Roger A H Adan
A reciprocal interaction between food-motivated behavior and diet-induced obesity.
International journal of obesity (2005) 2007;31(8):1286-94.
2007: Cigdem Gelegen; David A Collier; Iain C Campbell; Hugo Oppelaar; José van den Heuvel; Roger A H Adan; Martien J H Kas
Difference in susceptibility to activity-based anorexia in two inbred strains of mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(3):199-205.
2007: Mariken de Krom; Yvonne van der Schouw; Judith Hendriks; Roel A Ophoff; Carla H van Gils; Ronald P Stolk; Diederick Grobbee; Roger A H Adan
Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns.
Diabetes 2007;56(1):276-80.
2006: Mariken de Krom; Judith Hendriks; Jacquelien J G Hillebrand; Annemarie A Van Elburg; Roger A H Adan
A polymorphism in the 3' untranslated region of the CCK gene is associated with anorexia nervosa in Dutch patients.
Psychiatric genetics 2006;16(6):239.
2006: Roger A H Adan; Birgitte Tiesjema; Jacquelien J G Hillebrand; Susanne E La Fleur; Martien J H Kas; Mariken de Krom
The MC4 receptor and control of appetite.
British journal of pharmacology 2006;149(7):815-27.
2006: Caroline T M van Rossum; H Pijl; Roger A H Adan; Barbara Hoebee; jacob seidell
Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults.
International journal of obesity (2005) 2006;30(10):1522-8.
2006: Jacquelien J G Hillebrand; Martien J H Kas; Roger A H Adan
To eat or not to eat; regulation by the melanocortin system.
Physiology & behavior 2006;89(1):97-102.
2006: Jacquelien J G Hillebrand; Martien J H Kas; Anton J W Scheurink; Gertjan van Dijk; Roger A H Adan
AgRP(83-132) and SHU9119 differently affect activity-based anorexia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2006;16(6):403-12.
2006: Roger A H Adan; Gertjan van Dijk
Melanocortin receptors as drug targets for disorders of energy balance.
CNS & neurological disorders drug targets 2006;5(3):251-61.
2006: Roger A H Adan
Constitutive receptor activity series: endogenous inverse agonists and constitutive receptor activity in the melanocortin system.
Trends in pharmacological sciences 2006;27(4):183-6.
2006: Jacquelien J G Hillebrand; A C M Heinsbroek; Martien J H Kas; Roger A H Adan
The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia.
Journal of molecular endocrinology 2006;36(1):153-62.
2006: A F Maarten Altelaar; Ivo Klinkert; Kees Jalink; Bo De Lange; Roger A H Adan; Ron M A Heeren; Sander R Piersma
Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry.
Analytical chemistry 2006;78(3):734-42.
2005: Mariken de Krom; Corine E De Rijke; Judith Hendriks; Herman van Engeland; Annemarie A Van Elburg; Roger A H Adan
Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.
Psychiatric genetics 2005;15(4):237.
2005: Gertjan van Dijk; Koert de Vries; Csaba Nyakas; Bauke Buwalda; Tiziana Adage; Folkert Kuipers; Martien J H Kas; Roger A H Adan; Charles William Wilkinson; Todd E Thiele; Anton J W Scheurink
Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.
Endocrinology 2005;146(12):5247-56.
2005: Jacquelien J G Hillebrand; Annemarie A Van Elburg; Martien J H Kas; Herman van Engeland; Roger A H Adan
Olanzapine reduces physical activity in rats exposed to activity-based anorexia: possible implications for treatment of anorexia nervosa?
Biological psychiatry 2005;58(8):651-7.
2005: Corine E De Rijke; Jacquelien J G Hillebrand; L A W Verhagen; T A P Roeling; Roger A H Adan
Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats.
Journal of molecular endocrinology 2005;35(2):381-90.
2005: Jacquelien J G Hillebrand; Martien J H Kas; Roger A H Adan
alpha-MSH enhances activity-based anorexia.
Peptides 2005;26(10):1690-6.
2005: Martien J H Kas; Adrie W Bruijnzeel; Jurgen Haanstra; Victor M Wiegant; Roger A H Adan
Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event.
Journal of molecular endocrinology 2005;35(1):159-64.
2005: Jacquelien J G Hillebrand; Maarten P Koeners; Corine E De Rijke; Martien J H Kas; Roger A H Adan
Leptin treatment in activity-based anorexia.
Biological psychiatry 2005;58(2):165-71.
2005: Corine E De Rijke; Pilgrim J Jackson; Keith M Garner; Rea J van Rozen; Nick R Douglas; Martien J H Kas; Glenn L Millhauser; Roger A H Adan
Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.
Biochemical pharmacology 2005;70(2):308-16.
2005: Bas Wels; John A W Kruijtzer; Keith M Garner; Wouter A J Nijenhuis; Willem Hendrik Gispen; Roger A H Adan; Rob M J Liskamp
Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis.
Bioorganic & medicinal chemistry 2005;13(13):4221-7.
2005: John A W Kruijtzer; Wouter A J Nijenhuis; Nienke Wanders; Willem Hendrik Gispen; Rob M J Liskamp; Roger A H Adan
Peptoid-peptide hybrids as potent novel melanocortin receptor ligands.
Journal of medicinal chemistry 2005;48(13):4224-30.
2005: Jacquelien J G Hillebrand; Corine E De Rijke; Jan H Brakkee; Martien J H Kas; Roger A H Adan
Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia.
Physiology & behavior 2005;85(2):151-7.
2005: Mariken de Krom; Steven C Bakker; Judith Hendriks; Annemarie A Van Elburg; Mechteld L C Hoogendoorn; Wim Verduijn; Richard J Sinke; Rene Kahn; Roger A H Adan
Polymorphisms in the brain-derived neurotrophic factor gene are not associated with either anorexia nervosa or schizophrenia in Dutch patients.
Psychiatric genetics 2005;15(2):81.
2005: Bas Wels; John A W Kruijtzer; Keith M Garner; Roger A H Adan; Rob M J Liskamp
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups.
Bioorganic & medicinal chemistry letters 2005;15(2):287-90.
2004: Martien J H Kas; Birgitte Tiesjema; Gertjan van Dijk; Keith M Garner; Gregory S Barsh; Olivier ter Brake; Joost Verhaagen; Roger A H Adan
Induction of brain-region-specific forms of obesity by agouti.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(45):10176-81.
2004: Wouter A J Nijenhuis; Nienke Wanders; John A W Kruijtzer; Rob M J Liskamp; Willem Hendrik Gispen; Roger A H Adan
Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.
European journal of pharmacology 2004;495(2-3):145-52.
2003: Martien J H Kas; Annemarie A Van Elburg; Herman van Engeland; Roger A H Adan
Refinement of behavioural traits in animals for the genetic dissection of eating disorders.
European journal of pharmacology 2003;480(1-3):13-20.
2003: Dorien H Vrinten; Willem Hendrik Gispen; Cor Kalkman; Roger A H Adan
Interaction between the spinal melanocortin and opioid systems in a rat model of neuropathic pain.
Anesthesiology 2003;99(2):449-54.
2003: Wouter A J Nijenhuis; Keith M Garner; Rea J van Rozen; Roger A H Adan
Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.
The Journal of biological chemistry 2003;278(25):22939-45.
2003: Roger A H Adan; Jacquelien J G Hillebrand; Corine E De Rijke; Wouter A J Nijenhuis; Tom Vink; Keith M Garner; Martien J H Kas
Melanocortin system and eating disorders.
Annals of the New York Academy of Sciences 2003;994():267-74.
2003: Roger A H Adan; Martien J H Kas
Inverse agonism gains weight.
Trends in pharmacological sciences 2003;24(6):315-21.
2003: Mariël P ter Laak; Jan H Brakkee; Roger A H Adan; Frank P T Hamers; Willem Hendrik Gispen
The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.
European journal of pharmacology 2003;462(1-3):179-83.
2003: Wouter A J Nijenhuis; John A W Kruijtzer; Nienke Wanders; Dorien H Vrinten; Keith M Garner; Wim M M Schaaper; Rob H Meloen; Willem Hendrik Gispen; Rob M J Liskamp; Roger A H Adan
Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.
Peptides 2003;24(2):271-80.
2003: Martien J H Kas; Gertjan van Dijk; Anton J W Scheurink; Roger A H Adan
Agouti-related protein prevents self-starvation.
Molecular psychiatry 2003;8(2):235-40.
2002: Jacquelien J G Hillebrand; D de Wied; Roger A H Adan
Neuropeptides, food intake and body weight regulation: a hypothalamic focus.
Peptides 2002;23(12):2283-306.
2001: Dorien H Vrinten; Roger A H Adan; Gerbrand Groen; Willem Hendrik Gispen
Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain.
Anesthesia and analgesia 2001;93(6):1572-7, table of contents.
2001: Roger A H Adan; Tom Vink
Drug target discovery by pharmacogenetics: mutations in the melanocortin system and eating disorders.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2001;11(6):483-90.
2001: Dorien H Vrinten; Cor Kalkman; Roger A H Adan; Willem Hendrik Gispen
Neuropathic pain: a possible role for the melanocortin system?
European journal of pharmacology 2001;429(1-3):61-9.
2001: Tiziana Adage; Anton J W Scheurink; Sietse F De Boer; Koert de Vries; JP Konsman; Folkert Kuipers; Roger A H Adan; Denis Baskin; Michael W Schwartz; Gertjan van Dijk
Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3639-45.
2001: Tom Vink; A Hinney; Annemarie A Van Elburg; Stephanie H M van Goozen; Lodewijk A Sandkuijl; Richard J Sinke; B M Herpertz-Dahlmann; J Hebebrand; H Remschmidt; Herman van Engeland; Roger A H Adan
Association between an agouti-related protein gene polymorphism and anorexia nervosa.
Molecular psychiatry 2001;6(3):325-8.
2001: J Oosterom; Keith M Garner; Wouter A J Nijenhuis; Willem Hendrik Gispen; J Peter H Burbach; Gregory S Barsh; Roger A H Adan
Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein.
The Journal of biological chemistry 2001;276(2):931-6.
2001: Wouter A J Nijenhuis; J Oosterom; Roger A H Adan
AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor.
Molecular endocrinology (Baltimore, Md.) 2001;15(1):164-71.
2000: Joanne F Murray; Julian G Mercer; Roger A H Adan; J J Datta; C Aldairy; Kim M Moar; BI Baker; MJ Stock; CA Wilson
The effect of leptin on luteinizing hormone release is exerted in the zona incerta and mediated by melanin-concentrating hormone.
Journal of neuroendocrinology 2000;12(11):1133-9.
2000: Dorien H Vrinten; Willem Hendrik Gispen; Gerbrand Groen; Roger A H Adan
Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):8131-7.
2000: Roger A H Adan; Willem Hendrik Gispen
Melanocortins and the brain: from effects via receptors to drug targets.
European journal of pharmacology 2000;405(1-3):13-24.
2000: Joanne F Murray; Roger A H Adan; R Walker; BI Baker; Anthony J Thody; Wouter A J Nijenhuis; J Yukitake; CA Wilson
Melanin-concentrating hormone, melanocortin receptors and regulation of luteinizing hormone release.
Journal of neuroendocrinology 2000;12(3):217-23.
1999: Willem Hendrik Gispen; Roger A H Adan
Melanocortins and the treatment of nervous system disease. Potential relevance to the skin?
Annals of the New York Academy of Sciences 1999;885():342-9.
1999: Roger A H Adan; A W Szklarczyk; J Oosterom; Jan H Brakkee; Wouter A J Nijenhuis; Wim M M Schaaper; Rob H Meloen; Willem Hendrik Gispen
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
European journal of pharmacology 1999;378(3):249-58.
1999: J Oosterom; Wouter A J Nijenhuis; Wim M M Schaaper; Jerry W Slootstra; Rob H Meloen; Willem Hendrik Gispen; J Peter H Burbach; Roger A H Adan
Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors.
The Journal of biological chemistry 1999;274(24):16853-60.
1999: M van der Kraan; Jeffrey B Tatro; ML Entwistle; Jan H Brakkee; J Peter H Burbach; Roger A H Adan; Willem Hendrik Gispen
Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins.
Brain research. Molecular brain research 1999;63(2):276-86.
1998: Dirk Versteeg; P Van Bergen; Roger A H Adan; Dick J De Wildt
Melanocortins and cardiovascular regulation.
European journal of pharmacology 1998;360(1):1-14.
1998: J Oosterom; J Peter H Burbach; Willem Hendrik Gispen; Roger A H Adan
Asp10 in Lys-gamma2-MSH determines selective activation of the melanocortin MC3 receptor.
European journal of pharmacology 1998;354(1):R9-11.
1998: M van der Kraan; Roger A H Adan; ML Entwistle; Willem Hendrik Gispen; J Peter H Burbach; Jeffrey B Tatro
Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands.
Endocrinology 1998;139(5):2348-55.
1998: Josefien C von Frijtag; Gerda Croiset; Willem Hendrik Gispen; Roger A H Adan; Victor M Wiegant
The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal-axis and the induction of excessive grooming.
British journal of pharmacology 1998;123(8):1503-8.
1997: Roger A H Adan; J Oosterom; Ruud F G Toonen; M V Kraan; J Peter H Burbach; Willem Hendrik Gispen
Molecular pharmacology of neural melanocortin receptors.
Receptors & channels 1997;5(3-4):215-23.
1997: Roger A H Adan; Willem Hendrik Gispen
Brain melanocortin receptors: from cloning to function.
Peptides 1997;18(8):1279-87.
1996: Roger A H Adan; M van der Kraan; R P Doornbos; Peter R Bär; J Peter H Burbach; Willem Hendrik Gispen
Melanocortin receptors mediate alpha-MSH-induced stimulation of neurite outgrowth in neuro 2A cells.
Brain research. Molecular brain research 1996;36(1):37-44.
1995: J Peter; H Burbach; Roger A H Adan; S J Lolait; Fijs W B van Leeuwen; E Mezey; Miklós Palkovits; Claude Barberis
Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.
Cellular and molecular neurobiology 1995;15(5):573-95.
1995: Roger A H Adan; Fijs W B van Leeuwen; M A F Sonnemans; M Brouns; Gloria E Hoffman; Joseph G Verbalis; J Peter H Burbach
Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization.
Endocrinology 1995;136(9):4022-8.
1995: Roger A H Adan; Fijs W B van Leeuwen; M A F Sonnemans; Gloria E Hoffman; Joseph G Verbalis; J Peter H Burbach
The rat oxytocin receptor. cDNA cloning and immunocytochemical localization in brain, pituitary, mammary gland and uterus.
Advances in experimental medicine and biology 1995;395():345-6.
1995: J Peter H Burbach; H S A van Schaick; F M de Bree; S Lopes da Silva; Roger A H Adan
Functional domains in the oxytocin gene for regulation of expression and biosynthesis of gene products.
Advances in experimental medicine and biology 1995;395():9-21.
1994: Roger A H Adan; R D Cone; J Peter H Burbach; Willem Hendrik Gispen
Differential effects of melanocortin peptides on neural melanocortin receptors.
Molecular pharmacology 1994;46(6):1182-90.
1994: Roger A H Adan; J Oosterom; G Ludvigsdottir; Jan H Brakkee; J Peter H Burbach; Willem Hendrik Gispen
Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors.
European journal of pharmacology 1994;269(3):331-7.
1994: J Peter H Burbach; S Lopes da Silva; JJ Cox; Roger A H Adan; A J Cooney; M J Tsai; S Y Tsai
Repression of estrogen-dependent stimulation of the oxytocin gene by chicken ovalbumin upstream promoter transcription factor I.
The Journal of biological chemistry 1994;269(21):15046-53.
1993: J Peter H Burbach; Roger A H Adan
The rat oxytocin gene. Physiological changes in expression in the hypothalamo-neurohypophysial system and responsiveness of promoter activity.
Annals of the New York Academy of Sciences 1993;689():34-49.
1993: S Lopes da Silva; Roger A H Adan; J Peter H Burbach
Transcriptional regulation of the rat oxytocin promoter. Activation and suppression by members of the steroid/thyroid hormone receptor family.
Annals of the New York Academy of Sciences 1993;684():227-9.
1993: J Peter H Burbach; Roger A H Adan; JJ Cox; S L da Silva
Transactivation of the rat oxytocin and vasopressin promoters by nuclear hormone receptors.
Regulatory peptides 1993;45(1-2):31-5.
1993: Roger A H Adan; JJ Cox; Timothy Beischlag; J Peter H Burbach
A composite hormone response element mediates the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1993;7(1):47-57.
1992: J Peter H Burbach; Roger A H Adan; F M de Bree
Regulation of oxytocin gene expression and forms of oxytocin in the brain.
Annals of the New York Academy of Sciences 1992;652():1-13.
1992: Roger A H Adan; JJ Cox; J P van Kats; J Peter H Burbach
Thyroid hormone regulates the oxytocin gene.
The Journal of biological chemistry 1992;267(6):3771-7.
1992: Roger A H Adan; J Peter H Burbach
Regulation of vasopressin and oxytocin gene expression by estrogen and thyroid hormone.
Progress in brain research 1992;92():127-36.
1991: Roger A H Adan; N Walther; JJ Cox; R Ivell; J Peter H Burbach
Comparison of the estrogen responsiveness of the rat and bovine oxytocin gene promoters.
Biochemical and biophysical research communications 1991;175(1):117-22.
1990: M A Verbeeck; Roger A H Adan; J Peter H Burbach
Vasopressin gene expression is stimulated by cyclic AMP in homologous and heterologous expression systems.
FEBS letters 1990;272(1-2):89-93.
1990: J Peter; H Burbach; Roger A H Adan; H H Tol; M A Verbeeck; J F Axelson; F W Leeuwen; J M Beekman; G Ab
Regulation of the rat oxytocin gene by estradiol.
Journal of neuroendocrinology 1990;2(5):633-9.