FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Leslie Lange

Research Profile

Genes & Molecular Sequences

Physiology

Living Beings

Disorders

Concepts & Ideas

Chemicals & Drugs

C-Reactive Protein

Procedures

Geographic Areas

Philippines

Co-author Network

Publications

TOP 3
Alexander P Reiner; Jeremy Walston; Paulo H M Chaves; Mary Cushman; Jaclyn Ellis; Nancy Swords Jenny; Ethan M Lange; Leslie A Lange; Jin Li; Russell P Tracy
Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.
Ying Wu; Yun Li; Thomas W McDade; Karen L Mohlke; Linda S Adair; Judith Borja; Christopher W Kuzawa; Leslie A Lange
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
Damien C Croteau-Chonka; Amanda F Marvelle; Ethan M Lange; Nanette R Lee; Linda S Adair; Leslie A Lange; Karen L Mohlke
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Leslie Lange (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Alexander P Reiner; Jeremy Walston; Paulo H M Chaves; Mary Cushman; Jaclyn Ellis; Nancy Swords Jenny; Ethan M Lange; Leslie A Lange; Jin Li; Russell P Tracy
Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(1):158-64.
2012: Ying Wu; Yun Li; Thomas W McDade; Karen L Mohlke; Linda S Adair; Judith Borja; Christopher W Kuzawa; Leslie A Lange
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
Inflammation 2012;35(2):574-83.
2011: Damien C Croteau-Chonka; Amanda F Marvelle; Ethan M Lange; Nanette R Lee; Linda S Adair; Leslie A Lange; Karen L Mohlke
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
Obesity (Silver Spring, Md.) 2011;19(5):1019-27.
2011: N A Zakai; Leslie A Lange; William T Longstreth; Ellen S O'Meara; J L Kelley; Myriam Fornage; D Nikerson; Mary Cushman; Alexander P Reiner
Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study.
Journal of thrombosis and haemostasis : JTH 2011;9(2):267-74.
2011: M Graff; Kari E North; Keri Monda; Ethan M Lange; Leslie A Lange; Guang Guo; Penny Gordon-Larsen
The combined influence of genetic factors and sedentary activity on body mass changes from adolescence to young adulthood: the National Longitudinal Adolescent Health Study.
Diabetes/metabolism research and reviews 2011;27(1):63-9.
2010: Kari E North; Mariaelisa Graff; Linda S Adair; Ethan M Lange; Leslie A Lange; Guang Guo; Penny Gordon-Larsen
Genetic epidemiology of BMI and body mass change from adolescence to young adulthood.
Obesity (Silver Spring, Md.) 2010;18(7):1474-6.
2010: Leslie A Lange; Damien C Croteau-Chonka; Amanda F Marvelle; Li Qin; Kyle J Gaulton; Christopher W Kuzawa; Thomas W McDade; Yunfei Wang; Yun Li; Shawn Levy; Judith B Borja; Ethan M Lange; Linda S Adair; Karen L Mohlke
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults.
Human molecular genetics 2010;19(10):2050-8.
2010: Cara L Carty; Patrick J Heagerty; Susan R Heckbert; Gail P Jarvik; Leslie A Lange; Mary Cushman; Russell P Tracy; Alexander P Reiner
Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.
Annals of human genetics 2010;74(1):1-10.
2009: Iris M Heid; Cornelia Huth; Ruth J F Loos; Florian Kronenberg; Vera Adamkova; Sonia S Anand; Kristin Ardlie; Heike Biebermann; Peter Bjerregaard; Heiner Boeing; Claude Bouchard; Marina Ciullo; Jackie A Cooper; Dolores Corella; Christian Dina; James C Engert; Eva Fisher; Francesc Francès; Philippe Froguel; Johannes Hebebrand; Robert A Hegele; Anke Hinney; Margret R Hoehe; Frank B Hu; Jaroslav A Hubacek; Steve E Humphries; Steven C Hunt; Thomas Illig; Marjo-Riita Järvelin; Marika Kaakinen; Barbara Kollerits; Heiko Krude; Jitender Kumar; Leslie A Lange; Birgit Langer; Shengxu Li; Andreas Luchner; Helen N Lyon; David Meyre; Karen L Mohlke; Vincent Mooser; Almut Nebel; Thuy Trang Nguyen; Bernhard Paulweber; Louis Perusse; Lu Qi; Tuomo Rankinen; Dieter Rosskopf; Stefan Schreiber; Shantanu Sengupta; Rossella Sorice; Anita Suk; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Henry Völzke; Karani S Vimaleswaran; Nicholas J Wareham; Dawn Waterworth; Salim Yusuf; Cecilia Lindgren; Mark I McCarthy; Christoph Lange; Joel N Hirschhorn; Nan Laird; H-Erich Wichmann
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
PLoS genetics 2009;5(10):e1000694.
2009: N L Smith; K L Wiggins; A P Reiner; Leslie A Lange; M Cushman; S R Heckbert; T Lumley; K M Rice; A R Folsom; B M Psaty
Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2009;7(10):1743-6.
2009: Alexander P Reiner; Leslie A Lange; Nicholas L Smith; N A Zakai; Mary Cushman; A R Folsom
Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study.
Journal of thrombosis and haemostasis : JTH 2009;7(9):1499-505.
2009: Alexander P Reiner; Myron D Gross; Christopher S Carlson; Suzette J Bielinski; Leslie A Lange; Myriam Fornage; Nancy Swords Jenny; Jeremy Walston; Russell P Tracy; Dale O Williams; David R Jacobs; Deborah A Nickerson
Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study.
Circulation. Cardiovascular genetics 2009;2(3):244-54.
2009: Jeremy Walston; Amy M Matteini; Caroline Nievergelt; Leslie A Lange; Dani M Fallin; Nir Barzilai; Elad Ziv; Ludmila Pawlikowska; Pui Kwok; Steve R Cummings; Charles Kooperberg; Andrea LaCroix; Russell P Tracy; Gil Atzmon; Ethan M Lange; Alex P Reiner
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
Experimental gerontology 2009;44(5):350-5.
2008: Alicia K Smith; Leslie A Lange; Elizabeth J Ampleford; Deborah A Meyers; Eugene R Bleecker; Timothy D Howard
Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(11):1738-44.
2008: Alexander P Reiner; Cara L Carty; Nancy Swords Jenny; Caroline Nievergelt; Mary Cushman; D J Stearns-Kurosawa; S Kurosawa; Lewis H Kuller; Leslie A Lange
PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study.
Journal of thrombosis and haemostasis : JTH 2008;6(10):1625-32.
2008: Ethan M Lange; Jielin Sun; Leslie A Lange; S Lilly Zheng; David Duggan; John D Carpten; Henrik Gronberg; William B Isaacs; Jianfeng Xu; Bao-Li Chang
Family-based samples can play an important role in genetic association studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(9):2208-14.
2008: Alexander P Reiner; Mark M Wurfel; Leslie A Lange; Christopher S Carlson; Alex S Nord; Cara L Carty; Mark J Rieder; Cindy Desmarais; Nancy Swords Jenny; Carlos Iribarren; Jeremy Walston; Dale O Williams; Deborah A Nickerson; Gail P Jarvik
Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1407-12.
2008: Amanda F Marvelle; Leslie A Lange; Li Qin; Linda S Adair; Karen L Mohlke
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
Diabetes 2008;57(7):1987-91.
2008: Abigail S Caudle; Hong Jin Kim; Joel E Tepper; Bert O Neil; Leslie A Lange; Richard M Goldberg; Stephen A Bernard; Benjamin F Calvo; Michael O Meyers
Diabetes mellitus affects response to neoadjuvant chemoradiotherapy in the management of rectal cancer.
Annals of surgical oncology 2008;15(7):1931-6.
2008: Alexander P Reiner; Mathew Barber; Yongtao Guan; Paul M Ridker; Leslie A Lange; Daniel I Chasman; Jeremy Walston; Gregory Cooper; Nancy S Jenny; Mark J Rieder; J Peter Durda; joshua smith; John Novembre; Russell P Tracy; Jerome I Rotter; Matthew Stephens; Deborah A Nickerson; Ronald M Krauss
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
American journal of human genetics 2008;82(5):1193-201.
2008: Daniel B Campbell; Leslie A Lange; Tara Skelly; Jeffrey Lieberman; Pat Levitt; Patrick F Sullivan
Association of RGS2 and RGS5 variants with schizophrenia symptom severity.
Schizophrenia research 2008;101(1-3):67-75.
2008: Jielin Sun; Ethan M Lange; Sarah D Isaacs; Wennuan Liu; Kathy E Wiley; Leslie A Lange; Henrik Gronberg; David Duggan; John D Carpten; Patrick C Walsh; Jianfeng Xu; Bao-Li Chang; William B Isaacs; S Lilly Zheng
Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.
The Prostate 2008;68(5):489-97.
2008: Leslie A Lange; Alexander P Reiner; C L Carty; N S Jenny; M Cushman; Ethan M Lange
Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults.
Journal of thrombosis and haemostasis : JTH 2008;6(4):654-9.
2008: Lucia A Hindorff; Kenneth M Rice; Leslie A Lange; Paula Diehr; INDRANI HALDER; Jeremy Walston; Pui Kwok; Elad Ziv; Caroline Nievergelt; Steven R Cummings; Anne B Newman; Russell P Tracy; Bruce M Psaty; Alexander P Reiner
Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.
Atherosclerosis 2008;197(2):922-30.
2008: Rozenn N Lemaitre; Susan R Heckbert; Nona Sotoodehnia; Joshua C Bis; Nicholas L Smith; Kristin D Marciante; Lucia A Hindorff; Leslie A Lange; Thomas Lumley; Kenneth M Rice; Kerri L Wiggins; Bruce M Psaty
beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke.
American journal of hypertension 2008;21(3):290-6.
2008: Aruna V Sarma; Rodney L Dunn; Leslie A Lange; Anna Ray; Yunfei Wang; Ethan M Lange; Kathleen Cooney
Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.
The Prostate 2008;68(3):296-305.
2008: Cara L Carty; Mary Cushman; Daniel Jones; Leslie A Lange; Lucia A Hindorff; Kenneth Rice; Nancy Swords Jenny; J Peter Durda; Jeremy Walston; Christopher S Carlson; Debbie Nickerson; Russell P Tracy; Alexander P Reiner
Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study.
Thrombosis and haemostasis 2008;99(2):388-95.
2008: Lisa R Susswein; Cecile Skrzynia; Leslie A Lange; Jessica K Booker; Mark Graham II; James P Evans
Increased uptake of BRCA1/2 genetic testing among African American women with a recent diagnosis of breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(1):32-6.
2007: Jeremy Walston; MARGARET D FALLIN; Mary Cushman; Leslie A Lange; Bruce M Psaty; Nancy Jenny; Warren Browner; Russell Tracy; Peter Durda; Alex Reiner
IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study.
Human genetics 2007;122(5):485-94.
2007: T Skelly; Andréa Poyastro Pinheiro; Leslie A Lange; Patrick F Sullivan
Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia?
Molecular psychiatry 2007;12(4):321-2.
2007: Patrick F Sullivan; Richard S E Keefe; Leslie A Lange; Ethan M Lange; Thomas Stroup; Jeffrey Lieberman; Patricia F Maness
NCAM1 and neurocognition in schizophrenia.
Biological psychiatry 2007;61(7):902-10.
2007: Guang Guo; Yuying Tong; Cui-Wei Xie; Leslie A Lange
Dopamine transporter, gender, and number of sexual partners among young adults.
European journal of human genetics : EJHG 2007;15(3):279-87.
2007: Andréa Poyastro Pinheiro; Richard S E Keefe; Tara Skelly; Megan Olarte; Keren Leviel; Leslie A Lange; Ethan M Lange; Thomas Stroup; Jeffrey Lieberman; Patrick F Sullivan
AKT1 and neurocognition in schizophrenia.
The Australian and New Zealand journal of psychiatry 2007;41(2):169-77.
2007: Amanda F Marvelle; Leslie A Lange; Li Qin; Yunfei Wang; Ethan M Lange; Linda S Adair; Karen L Mohlke
Comparison of ENCODE region SNPs between Cebu Filipino and Asian HapMap samples.
Journal of human genetics 2007;52(9):729-37.
2006: Leslie A Lange; Christopher S Carlson; Lucia A Hindorff; Ethan M Lange; Jeremy Walston; J Peter Durda; Mary Cushman; Joshua C Bis; Donglin Zeng; Danyu Lin; Lewis H Kuller; Deborah A Nickerson; Bruce M Psaty; Russell P Tracy; Alexander P Reiner
Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events.
JAMA : the journal of the American Medical Association 2006;296(22):2703-11.
2006: Leslie A Lange; Kathryn P Burdon; Carl D Langefeld; Yongmei Liu; Stephanie R Beck; Stephen S Rich; Barry I Freedman; K Bridget Brosnihan; David M Herrington; Lynne E Wagenknecht; Donald W Bowden
Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study.
Annals of human genetics 2006;70(Pt 6):717-25.
2006: T Li; Leslie A Lange; X Li; Lisa R Susswein; Mary Shilliday; Robert M Malone; Ethan M Lange; T-Y Huang; D W Stafford; James P Evans
Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.
Journal of medical genetics 2006;43(9):740-4.
2006: Ethan M Lange; Lindsey A Ho; Jennifer L Beebe; Yunfei Wang; Elizabeth M Gillanders; Jeffrey M. Trent; Leslie A Lange; David P Wood Jr; Kathleen Cooney
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12.
Human genetics 2006;119(4):400-7.
2006: Sharon L R Kardia; Lawrence F Bielak; Leslie A Lange; James M Cheverud; Eric Boerwinkle; Stephen T Turner; Patrick F Sheedy; Patricia A Peyser
Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification.
Medical science monitor : international medical journal of experimental and clinical research 2006;12(4):CR150-8.
2006: Antoon Dijkstra; Timothy Howard; Judith M Vonk; Elizabeth J Ampleford; Leslie A Lange; Eugene R Bleecker; Deborah A Meyers; Dirkje S Postma
Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma.
The Journal of allergy and clinical immunology 2006;117(3):604-11.
2006: Bao-Li Chang; Ethan M Lange; Latchezar Dimitrov; Christopher J Valis; Elizabeth M Gillanders; Leslie A Lange; Kathy E Wiley; Sarah D Isaacs; Fredrik Wiklund; Agnes B Baffoe-Bonnie; Carl D Langefeld; S Lilly Zheng; Mika P Matikainen; Tarja Ikonen; Henna Fredriksson; Teuvo Tammela; Patrick C Walsh; Joan E Bailey-Wilson; Johanna Schleutker; Henrik Gronberg; Kathleen Cooney; William B Isaacs; Edward Suh; Jeffrey M. Trent; Jianfeng Xu
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect.
Human genetics 2006;118(6):716-24.
2006: Jennifer L Beebe; Leslie A Lange; J E Cain; R C Lewis; Anna M Ray; Aruna V Sarma; Ethan M Lange; Kathleen Cooney
Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.
Prostate cancer and prostatic diseases 2006;9(1):50-5.
2006: Timothy A Bell; Elena de La Casa-Esperón; Heather E Doherty; Folami Ideraabdullah; Kuikwon Kim; Yunfei Wang; Leslie A Lange; Kirk Wilhemsen; Ethan M Lange; Carmen Sapienza; Fernando Villena
The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
Genetics 2006;172(1):411-23.
2005: Marc A Schuckit; Kirk Wilhelmsen; Tom L Smith; Heidi S Feiler; Penelope Lind; Leslie A Lange; Jelger Kalmijn
Autosomal linkage analysis for the level of response to alcohol.
Alcoholism, clinical and experimental research 2005;29(11):1976-82.
2005: Donald W Bowden; Leslie A Lange; Carl D Langefeld; K Bridget Brosnihan; Barry I Freedman; John Carr; Lynne E Wagenknecht; David M Herrington
The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS).
American heart journal 2005;150(5):1032-8.
2005: Barbara J Nicklas; Josyf C Mychaleckyj; Stephen B Kritchevsky; Shana Palla; Leslie A Lange; Ethan M Lange; Stephen P Messier; Don Bowden; Marco Pahor
Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(10):1292-8.
2005: Timothy Howard; Wayne H Giles; Jianfeng Xu; Marcella A Wozniak; Ann M Malarcher; Leslie A Lange; Richard F Macko; Monica J Basehore; Deborah A Meyers; John W Cole; Steven Kittner
Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women.
Stroke; a journal of cerebral circulation 2005;36(9):1848-51.
2005: Leslie A Lange; Jill M Norris; Carl D Langefeld; Barbara J Nicklas; Lynne E Wagenknecht; Mohammed F Saad; Donald W Bowden
Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study.
International journal of obesity (2005) 2005;29(5):449-57.
2005: Fang-Chi Hsu; Daniel J Zaccaro; Leslie A Lange; Donna K Arnett; Carl D Langefeld; Lynne E Wagenknecht; David M Herrington; Stephanie R Beck; Barry I Freedman; Donald W Bowden; Stephen S Rich
The impact of pedigree structure on heritability estimates for pulse pressure in three studies.
Human heredity 2005;60(2):63-72.
2004: Jennifer L Bento; Nicholette D Palmer; Josyf C Mychaleckyj; Leslie A Lange; Carl D Langefeld; Stephen S Rich; Barry I Freedman; Donald W Bowden
Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes.
Diabetes 2004;53(11):3007-12.
2004: Deborah A Meyers; Michael J Larj; Leslie A Lange
Genetics of asthma and COPD. Similar results for different phenotypes.
Chest 2004;126(2 Suppl):105S-110S; discussion 159S-161S.
2004: Monica J Basehore; Timothy Howard; Leslie A Lange; Wendy C Moore; Gregory A Hawkins; Patricia L Marshik; Michelle S Harkins; Deborah A Meyers; Eugene R Bleecker
A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects.
The Journal of allergy and clinical immunology 2004;114(1):80-7.
2003: Jeannette T Bensen; Leslie A Lange; Carl D Langefeld; Bao-Li Chang; Eugene R Bleecker; Deborah A Meyers; Jianfeng Xu
Exploring pleiotropy using principal components.
BMC genetics 2003;4 Suppl 1():S53.
2003: John E Hokanson; Carl D Langefeld; Braxton D Mitchell; Leslie A Lange; David C Goff; Steven M Haffner; Mohammed F Saad; Jerome I Rotter
Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study.
Human heredity 2003;55(1):46-50.
2002: Leslie A Lange; Donald W Bowden; Carl D Langefeld; Lynne E Wagenknecht; John Carr; Stephen S Rich; Ward A Riley; Barry I Freedman
Heritability of carotid artery intima-medial thickness in type 2 diabetes.
Stroke; a journal of cerebral circulation 2002;33(7):1876-81.
2002: Leslie A Lange; Ethan M Lange; Lawrence F Bielak; Carl D Langefeld; Sharon L R Kardia; Patrick Royston; Stephen T Turner; Patrick F Sheedy; Eric Boerwinkle; Patricia A Peyser
Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):418-23.
2000: Elisa M Ghezzi; Leslie A Lange; Jonathan A Ship
Determination of variation of stimulated salivary flow rates.
Journal of dental research 2000;79(11):1874-8.