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Ulo Langel

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TOP 3
Luís Vasconcelos; Kalle Pärn; Ulo Langel
Therapeutic potential of cell-penetrating peptides.
Piret Arukuusk; Dana-Maria Copolovici; Gaily Kivi; Helerin Margus; Julia Maslovskaja; Kaidi Möll; Nikita Oskolkov; Kärt Padari; Ly Pärnaste; Margus Pooga; Radi Tegova; Andres Tover; Mart Ustav; Ulo Langel
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids.
Fatemeh Madani; Rania Abdo; Shiroh Futaki; Hisaaki Hirose; Ulo Langel; Staffan Lindberg; Astrid Gräslund
Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient.

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All Publications

2013: Luís Vasconcelos; Kalle Pärn; Ulo Langel
Therapeutic potential of cell-penetrating peptides.
Therapeutic delivery 2013;4(5):573-91.
2013: Piret Arukuusk; Dana-Maria Copolovici; Gaily Kivi; Helerin Margus; Julia Maslovskaja; Kaidi Möll; Nikita Oskolkov; Kärt Padari; Ly Pärnaste; Margus Pooga; Radi Tegova; Andres Tover; Mart Ustav; Ulo Langel
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids.
Biochimica et biophysica acta 2013;1828(5):1365-73.
2013: Fatemeh Madani; Rania Abdo; Shiroh Futaki; Hisaaki Hirose; Ulo Langel; Staffan Lindberg; Astrid Gräslund
Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient.
Biochimica et biophysica acta 2013;1828(4):1198-204.
2013: Elo Eriste; John Howl; Sarah Jones; Kaido Kurrikoff; Pirjo Laakkonen; Nikita Oskolkov; Julia Suhorutšenko; Dana Maria Copolovici; Ulo Langel
Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2.
Bioconjugate chemistry 2013;24(3):305-13.
2013: Maria E Anderson; Ulo Langel; Johan Runesson; Indrek Saar; John K Robinson
Galanin, through GalR1 but not GalR2 receptors, decreases motivation at times of high appetitive behavior.
Behavioural brain research 2013;239():90-3.
2013: Indrek Saar; Johan Runesson; Jaak Järv; Kaido Kurrikoff; Ulo Langel
Novel galanin receptor subtype specific ligand in depression like behavior.
Neurochemical research 2013;38(2):398-404.
2013: Staffan Lindberg; Diogo Mosqueira; Andrés Muñoz-Alarcón; Oana Tudoran; Daniel Gyllborg; Henrik Helmfors; Ulo Langel
PepFect15, a novel endosomolytic cell-penetrating peptide for oligonucleotide delivery via scavenger receptors.
International journal of pharmaceutics 2013;441(1-2):242-7.
2013: Kadi-Liis Veiman; Piret Arukuusk; Kariem Ezzat; Kaido Kurrikoff; Kent Langel; Taavi Lehto; Taavi Lehto; Imre Mäger; Helerin Margus; Kärt Padari; Margus Pooga; Julia Suhorutšenko; Ulo Langel
PepFect14 peptide vector for efficient gene delivery in cell cultures.
Molecular pharmaceutics 2013;10(1):199-210.
2013: Jakob Regberg; Jonas N K Eriksson; Ulo Langel
Cell-penetrating peptides: from cell cultures to in vivo applications.
Frontiers in bioscience (Elite edition) 2013;5():509-16.
2012: Gen Tanaka; Nobutaka Fujii; Yasunori Fukuda; Astrid Gräslund; Yasumaru Hatanaka; Yoshimasa Kawaguchi; Ulo Langel; Ryo Masuda; Masao Matsuoka; Ikuhiko Nakase; Shinya Oishi; Katsuya Okawa; Kazuya Shimura; Tomoka Takatani-Nakase; Shiroh Futaki
CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV.
Chemistry & biology 2012;19(11):1437-46.
2012: John Howl; Michelle Farquhar; Shant Kumar; Ulo Langel; Sabine Matou-Nasri; Jane McKeating; Claes-Göran Ostenson; Pernilla Ostlund; Jiřina Slaninová; David C West; Matjaz Zorko; Sarah Jones
Bioportide: an emergent concept of bioactive cell-penetrating peptides.
Cellular and molecular life sciences : CMLS 2012;69(17):2951-66.
2012: Kariem Ezzat; Samir El-Andaloussi; Ramy El-Sayed; Taavi Lehto; Tarek Magdy; C I Edvard Smith; Eman M Zaghloul; Ulo Langel
Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(1):1-8.
2012: Sophie Laffray; Ulo Langel; Yves Le Feuvre; Frédéric Nagy; Marie-Amélie Papon; Corentin Spriet; Rabia Bouali-Benazzouz; Marion Decossas; Pascal Desbarats; Alexandre Favereaux; Pascal Fossat; Laurent Héliot; Tina Holm; Yang Jiang; Marc Landry
Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions.
The EMBO journal 2012;31(15):3239-51.
2012: Ikuhiko Nakase; Hidetaka Akita; Astrid Gräslund; Hideyoshi Harashima; Kentaro Kogure; Ulo Langel; Shiroh Futaki
Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides.
Accounts of chemical research 2012;45(7):1132-9.
2012: Taavi Lehto; Kaido Kurrikoff; Ulo Langel
Cell-penetrating peptides for the delivery of nucleic acids.
Expert opinion on drug delivery 2012;9(7):823-36.
2012: Annely Lorents; Nikita Oskolkov; Mattias Hällbrink; Praveen Kumar Kodavali; Ulo Langel; Margus Pooga
Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration.
The Journal of biological chemistry 2012;287(20):16880-9.
2012: Maja Anko; Ksenija Kogej; Ulo Langel; Janja Majhenc; Rannard Sillard; Gregor Anderluh; Matjaz Zorko
Influence of stearyl and trifluoromethylquinoline modifications of the cell penetrating peptide TP10 on its interaction with a lipid membrane.
Biochimica et biophysica acta 2012;1818(3):915-24.
2012: Imre Mäger; Taavi Lehto; Emelía Eiríksdóttir; Kent Langel; Ulo Langel
The role of endocytosis on the uptake kinetics of luciferin-conjugated cell-penetrating peptides.
Biochimica et biophysica acta 2012;1818(3):502-11.
2012: Kariem Ezzat; Henrik Helmfors; Carmen Juks; Staffan Lindberg; Kärt Padari; Margus Pooga; Oana Tudoran; Samir El-Andaloussi; Ulo Langel
Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1172-80.
2012: Kristin E B Webling; Johan Runesson; Tamas Bartfai; Ulo Langel
Galanin receptors and ligands.
Frontiers in endocrinology 2012;3():146.
2012: Suvarna Dash-Wagh; Anders Fridberger; Stefan Jacob; Ulo Langel; Staffan Lindberg; Mats Ulfendahl
Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6.
Molecular therapy. Nucleic acids 2012;1():e61.
2012: Abiodun Ajayi; Ulo Langel; Staffan Lindberg; Xin Yu; Anna-Lena Strom
Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.
BMC neuroscience 2012;13():86.
2012: Andrés Muñoz-Alarcón; Cristian Romero; Jesper Wengel; Kim A Lennox; Mark A Behlke; Samir El-Andaloussi; Peter Guterstam; Ulo Langel
Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.
ISRN pharmaceutics 2012;2012():407154.
2011: Julia Suhorutsenko; Nikita Oskolkov; Piret Arukuusk; Dana-Maria Copolovici; Elo Eriste; Kaido Kurrikoff; Ulo Langel
Cell-penetrating peptides, PepFects, show no evidence of toxicity and immunogenicity in vitro and in vivo.
Bioconjugate chemistry 2011;22(11):2255-62.
2011: Anita Mann; Rangeetha Naik; Vasundhara Shukla; Anand Kamal Singh; Garima Thakur; Yang Jiang; Namita Kalra; Richa Khanduri; Ulo Langel; B S Dwarakanath; MUNIA gaNGULI
Differences in DNA condensation and release by lysine and arginine homopeptides govern their DNA delivery efficiencies.
Molecular pharmaceutics 2011;8(5):1729-41.
2011: Karin Öjemalm; Stephen H White; Ulo Langel; Takashi Higuchi; Yang Jiang; IngMarie Nilsson; Hiroaki Suga; Gunnar von Heijne
Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):E359-64.
2011: Fatouma Said Hassane; Taavi Lehto; Rannar Sillard; Rachida Abes; Samir El-Andaloussi; Ulo Langel; Bernard Lebleu
Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
Journal of controlled release : official journal of the Controlled Release Society 2011;153(2):163-72.
2011: Pille Säälik; Ulo Langel; Mats Hansen; Dmitri Lubenets; Aira Niinep; Janely Pae; Margus Pooga
Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles.
Journal of controlled release : official journal of the Controlled Release Society 2011;153(2):117-25.
2011: Kariem Ezzat; Michael J Gait; Peter Guterstam; Mattias Hällbrink; Suzan M Hammond; Taavi Lehto; Staffan Lindberg; Tarek Magdy; Pedro M D Moreno; Rannar Sillard; C I Edvard Smith; Joana R Viola; Matthew J A Wood; Eman M Zaghloul; Samir El-Andaloussi; Rania Abdo; Andrey A Arzumanov; Ulo Langel
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.
Nucleic acids research 2011;39(12):5284-98.
2011: Indrek Saar; Johan Runesson; Ilan McNamara; Jaak Järv; John K Robinson; Ulo Langel
Novel galanin receptor subtype specific ligands in feeding regulation.
Neurochemistry international 2011;58(6):714-20.
2011: Samir E L Andaloussi; Dana M Copolovici; Kariem Ezzat; Peter Guterstam; Jonas Hälldin; Henrik J Johansson; Kaido Kurrikoff; Bernard Lebleu; Janne Lehtiö; Taavi Lehto; Imre Mäger; Andres Metspalu; Pedro M D Moreno; Iulian I Oprea; Nikita Oskolkov; Katri Rosenthal-Aizman; Fatouma Said Hassane; Rannar Sillard; Oscar E Simonson; C I Edvard Smith; Helena Sork; Julia Suhorutšenko; Ulf Tedebark; Joana R Viola; Eman M Zaghloul; Ulo Langel
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.
Nucleic acids research 2011;39(9):3972-87.
2011: Staffan Lindberg; Dana M Copolovici; Ulo Langel
Therapeutic delivery opportunities, obstacles and applications for cell-penetrating peptides.
Therapeutic delivery 2011;2(1):71-82.
2011: Taavi Lehto; Kariem Ezzat; Ulo Langel
Peptide nanoparticles for oligonucleotide delivery.
Progress in molecular biology and translational science 2011;104():397-426.
2011: Samir El-Andaloussi; Ulo Langel; Fatouma Said Hassane; Rannar Sillard; Prisca Boisguerin; Bernard Lebleu
Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides.
Methods in molecular biology (Clifton, N.J.) 2011;764():75-89.
2011: Fatemeh Madani; Shiroh Futaki; Ulo Langel; Staffan Lindberg; Astrid Gräslund
Mechanisms of cellular uptake of cell-penetrating peptides.
Journal of biophysics (Hindawi Publishing Corporation : Online) 2011;2011():414729.
2011: Liane Viru; Ulo Langel; Kalle Pärn; Samir El-Andaloussi; Gregory Heller; Taavi Lehto; Andres Merits
Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells.
Virology journal 2011;8():243.
2011: Thomas J Bell; Emelía Eiríksdóttir; Ulo Langel; james eberwine
PAIR technology: exon-specific RNA-binding protein isolation in live cells.
Methods in molecular biology (Clifton, N.J.) 2011;683():473-86.
2011: Samir E L Andaloussi; Taavi Lehto; Per Lundin; Ulo Langel
Application of PepFect peptides for the delivery of splice-correcting oligonucleotides.
Methods in molecular biology (Clifton, N.J.) 2011;683():361-73.
2011: Henrik J Johansson; Samir E L Andaloussi; Ulo Langel
Mimicry of protein function with cell-penetrating peptides.
Methods in molecular biology (Clifton, N.J.) 2011;683():233-47.
2011: Peter Guterstam; Samir E L Andaloussi; Ulo Langel
Characterization of cellular internalization pathways for CPP-mediated oligonucleotide delivery.
Methods in molecular biology (Clifton, N.J.) 2011;683():219-30.
2011: Tina Holm; Samir E L Andaloussi; Ulo Langel
Comparison of CPP uptake methods.
Methods in molecular biology (Clifton, N.J.) 2011;683():207-17.
2011: Per Lundin; Samir E L Andaloussi; Ulo Langel
Toxicity methods for CPPs.
Methods in molecular biology (Clifton, N.J.) 2011;683():195-205.
2011: Helin Räägel; Pille Säälik; Ulo Langel; Margus Pooga
Mapping of protein transduction pathways with fluorescent microscopy.
Methods in molecular biology (Clifton, N.J.) 2011;683():165-79.
2011: Anders Florén; Imre Mäger; Ulo Langel
Uptake kinetics of cell-penetrating peptides.
Methods in molecular biology (Clifton, N.J.) 2011;683():117-28.
2011: Maria Lindgren; Ulo Langel
Classes and prediction of cell-penetrating peptides.
Methods in molecular biology (Clifton, N.J.) 2011;683():3-19.
2010: Johan Runesson; Ulla Sollenberg; Wiktor Jurkowski; Samira Yazdi; Einar E Eriksson; Arne Elofsson; Ulo Langel
Determining receptor-ligand interaction of human galanin receptor type 3.
Neurochemistry international 2010;57(7):804-11.
2010: Emelía Eiríksdóttir; Imre Mäger; Taavi Lehto; Samir El-Andaloussi; Ulo Langel
Cellular internalization kinetics of (luciferin-)cell-penetrating peptide conjugates.
Bioconjugate chemistry 2010;21(9):1662-72.
2010: Sarah Jones; Tina Holm; Imre Mäger; Ulo Langel; John Howl
Characterization of bioactive cell penetrating peptides from human cytochrome c: protein mimicry and the development of a novel apoptogenic agent.
Chemistry & biology 2010;17(7):735-44.
2010: Emelía Eiríksdóttir; Karidia Konate; Ulo Langel; Gilles Divita; Sébastien Deshayes
Secondary structure of cell-penetrating peptides controls membrane interaction and insertion.
Biochimica et biophysica acta 2010;1798(6):1119-28.
2010: Imre Mäger; Emelía Eiríksdóttir; Kent Langel; Samir El-Andaloussi; Ulo Langel
Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay.
Biochimica et biophysica acta 2010;1798(3):338-43.
2010: Pascal Fossat; Eric Dobremez; Rabia Bouali-Benazzouz; Alexandre Favereaux; Sandrine S Bertrand; Kalle Kilk; Claire Léger; Jean-René Cazalets; Ulo Langel; Marc Landry; Frédéric Nagy
Knockdown of L calcium channel subtypes: differential effects in neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(3):1073-85.
2010: Taavi Lehto; Rachida Abes; Nikita Oskolkov; Julia Suhorutsenko; Dana-Maria Copolovici; Imre Mäger; Joana R Viola; Oscar E Simonson; Kariem Ezzat; Peter Guterstam; Elo Eriste; C I Edvard Smith; Bernard Lebleu; Ulo Langel
Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(1):42-51.
2010: Kariem Ezzat; Samir El-Andaloussi; Rania Abdo; Ulo Langel
Peptide-based matrices as drug delivery vehicles.
Current pharmaceutical design 2010;16(9):1167-78.
2009: Peter Guterstam; Fatemeh Madani; Hisaaki Hirose; Toshihide Takeuchi; Shiroh Futaki; Samir El-Andaloussi; Astrid Gräslund; Ulo Langel
Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate.
Biochimica et biophysica acta 2009;1788(12):2509-17.
2009: Kalle Kilk; Riina Mahlapuu; Ursel Soomets; Ulo Langel
Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling.
Toxicology 2009;265(3):87-95.
2009: Maarja Mäe; Samir El Andaloussi; Taavi Lehto; Ulo Langel
Chemically modified cell-penetrating peptides for the delivery of nucleic acids.
Expert opinion on drug delivery 2009;6(11):1195-205.
2009: Helin Räägel; Pille Säälik; Mats Hansen; Ulo Langel; Margus Pooga
CPP-protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway.
Journal of controlled release : official journal of the Controlled Release Society 2009;139(2):108-17.
2009: Johan Runesson; Indrek Saar; Linda Lundström; Jaak Järv; Ulo Langel
A novel GalR2-specific peptide agonist.
Neuropeptides 2009;43(3):187-92.
2009: Pille Säälik; Kärt Padari; Aira Niinep; Annely Lorents; Mats Hansen; Eija Jokitalo; Ulo Langel; Margus Pooga
Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways.
Bioconjugate chemistry 2009;20(5):877-87.
2009: Maarja Mäe; Samir El-Andaloussi; Per Lundin; Nikita Oskolkov; Henrik J Johansson; Peter Guterstam; Ulo Langel
A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(3):221-7.
2008: Per Lundin; Henrik Johansson; Peter Guterstam; Tina Holm; Mats Hansen; Ulo Langel; Samir El-Andaloussi
Distinct uptake routes of cell-penetrating peptide conjugates.
Bioconjugate chemistry 2008;19(12):2535-42.
2008: Zoran Arsov; Marjana Nemec; Milan Schara; Henrik Johansson; Ulo Langel; Matjaz Zorko
Cholesterol prevents interaction of the cell-penetrating peptide transportan with model lipid membranes.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(12):1303-8.
2008: Vladana Vukojević; Yu Ming; Claudio D'Addario; Mats Hansen; Ulo Langel; Rüdiger Schulz; Björn Johansson; Rudolf Rigler; Lars Terenius
Mu-opioid receptor activation in live cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3537-48.
2008: Eugenia Kuteeva; Tara Wardi; Linda Lundström; Ulla Sollenberg; Ulo Langel; Tomas Hökfelt; Sven Ove Ogren
Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(11):2573-85.
2008: Romanico Arrighi; Charles Ebikeme; Yang Jiang; Lisa Ranford-Cartwright; Michael P Barrett; Ulo Langel; Ingrid Faye
Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
Antimicrobial agents and chemotherapy 2008;52(9):3414-7.
2008: Kjell Fuxe; Daniel Marcellino; A Rivera; Zaida Diaz-Cabiale; Malgorzata Filip; B Gago; D C S Roberts; Ulo Langel; Susanna Genedani; Luca Ferraro; A de la Calle; J Narvaez; Sergio Tanganelli; Amina S Woods; Luigi F Agnati
Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology.
Brain research reviews 2008;58(2):415-52.
2008: Kajsa Löfgren; Anna Wahlström; Pontus Lundberg; Ulo Langel; Astrid Gräslund; Katarina Bedecs
Antiprion properties of prion protein-derived cell-penetrating peptides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2177-84.
2008: Jessica J Hawes; Darlene H Brunzell; Roopashree Narasimhaiah; Ulo Langel; David Wynick; Marina R Picciotto
Galanin protects against behavioral and neurochemical correlates of opiate reward.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(8):1864-73.
2008: Kwai A Alier; Yishen Chen; Ulla E Sollenberg; Ulo Langel; Peter A Smith
Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin.
Pain 2008;137(1):138-46.
2008: Peter Guterstam; Maria Lindgren; Henrik Johansson; Ulf Tedebark; Jesper Wengel; Samir El-Andaloussi; Ulo Langel
Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers.
The Biochemical journal 2008;412(2):307-13.
2008: Tim H Holmström; Antoine Mialon; Marko Kallio; Yvonne Nymalm; Leni Mannermaa; Tina Holm; Henrik Johansson; Elizabeth Black; David Gillespie; Tiina A Salminen; Ulo Langel; Benigno C Valdez; Jukka Westermarck
c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.
The Journal of biological chemistry 2008;283(11):7046-53.
2008: Mats Hansen; Kalle Kilk; Ulo Langel
Predicting cell-penetrating peptides.
Advanced drug delivery reviews 2008;60(4-5):572-9.
2008: Pontus Lundberg; Kalle Kilk; Ulo Langel
Cell-Penetrating Peptide-Mediated Delivery of Peptide Nucleic Acid (PNA) Oligomers.
CSH protocols 2008;2008():pdb.prot4889.
2008: Helena Myrberg; Lianglin Zhang; Maarja Mäe; Ulo Langel
Design of a tumor-homing cell-penetrating peptide.
Bioconjugate chemistry 2008;19(1):70-5.
2008: Henrik J Johansson; Samir El-Andaloussi; Tina Holm; Maarja Mäe; Jaak Jänes; Toivo Maimets; Ulo Langel
Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):115-23.
2008: Kamila Oglecka; Pontus Lundberg; Mazin Magzoub; L E Göran Eriksson; Ulo Langel; Astrid Gräslund
Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects.
Biochimica et biophysica acta 2008;1778(1):206-13.
2007: Linda Lundström; Ulla Sollenberg; Tamas Bartfai; Ulo Langel
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions.
Journal of neurochemistry 2007;103(5):1774-84.
2007: Samir El-Andaloussi; Peter Järver; Henrik J Johansson; Ulo Langel
Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study.
The Biochemical journal 2007;407(2):285-92.
2007: Samir El-Andaloussi; Henrik J Johansson; Tina Holm; Ulo Langel
A novel cell-penetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(10):1820-6.
2007: Pontus Lundberg; Samir El-Andaloussi; Tolga Sutlu; Henrik J Johansson; Ulo Langel
Delivery of short interfering RNA using endosomolytic cell-penetrating peptides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2664-71.
2007: Peter Järver; K Langel; Samir El-Andaloussi; Ulo Langel
Applications of cell-penetrating peptides in regulation of gene expression.
Biochemical Society transactions 2007;35(Pt 4):770-4.
2007: Kersti Ehrlich; Säde Viirlaid; Riina Mahlapuu; Külliki Saar; Tiiu Kullisaar; Mihkel Zilmer; Ulo Langel; Ursel Soomets
Design, synthesis and properties of novel powerful antioxidants, glutathione analogues.
Free radical research 2007;41(7):779-87.
2007: Elsa Bárány-Wallje; Jugnu Gaur; Pontus Lundberg; Ulo Langel; Astrid Gräslund
Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo.
FEBS letters 2007;581(13):2389-93.
2007: Alice Blackshear; Mihoko Yamamoto; Brenda J Anderson; Philip V Holmes; Linda Lundström; Ulo Langel; John K Robinson
Intracerebroventricular administration of galanin or galanin receptor subtype 1 agonist M617 induces c-Fos activation in central amygdala and dorsomedial hypothalamus.
Peptides 2007;28(5):1120-4.
2007: Lindsay E Yandek; Antje Pokorny; Anders Florén; Kristina Knoelke; Ulo Langel; Paulo F F Almeida
Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers.
Biophysical journal 2007;92(7):2434-44.
2007: Aljosa Bavec; Yang Jiang; Ulo Langel; Matjaz Zorko
Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
Molecular biology reports 2007;34(1):53-60.
2007: Linda Fisher; Malin Samuelsson; Yang Jiang; Veronica Ramberg; Ricardo Figueroa; Einar Hallberg; Ulo Langel; Kerstin Iverfeldt
Targeting cytokine expression in glial cells by cellular delivery of an NF-kappaB decoy.
Journal of molecular neuroscience : MN 2007;31(3):209-19.
2007: Samir El-Andaloussi; Peter Guterstam; Ulo Langel
Assessing the delivery efficacy and internalization route of cell-penetrating peptides.
Nature protocols 2007;2(8):2043-7.
2007: Helena Myrberg; Maria Lindgren; Ulo Langel
Protein delivery by the cell-penetrating peptide YTA2.
Bioconjugate chemistry 2007;18(1):170-4.
2006: Samir El-Andaloussi; Henrik J Johansson; Pontus Lundberg; Ulo Langel
Induction of splice correction by cell-penetrating peptide nucleic acids.
The journal of gene medicine 2006;8(10):1262-73.
2006: Maarja Mäe; Ulo Langel
Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery.
Current opinion in pharmacology 2006;6(5):509-14.
2006: Mazin Magzoub; Staffan Sandgren; Pontus Lundberg; Kamila Oglecka; Johanna Lilja; Anders Wittrup; L E Göran Eriksson; Ulo Langel; Mattias Belting; Astrid Gräslund
N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis.
Biochemical and biophysical research communications 2006;348(2):379-85.
2006: Juan Miguel Jimenez-Andrade; Linda Lundström; Ulla Sollenberg; Ulo Langel; Gilberto Castañeda-Hernandez; Susan M Carlton
Activation of peripheral galanin receptors: differential effects on nociception.
Pharmacology, biochemistry, and behavior 2006;85(1):273-80.
2006: Andrey Mazarati; Linda Lundström; Ulla Sollenberg; Don Shin; Ulo Langel; Raman Sankar
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling.
The Journal of pharmacology and experimental therapeutics 2006;318(2):700-8.
2006: Anna Elmquist; Mats Hansen; Ulo Langel
Structure-activity relationship study of the cell-penetrating peptide pVEC.
Biochimica et biophysica acta 2006;1758(6):721-9.
2006: Peter Järver; Ulo Langel
Cell-penetrating peptides--a brief introduction.
Biochimica et biophysica acta 2006;1758(3):260-3.
2006: Maria Lindgren; Katri Rosenthal-Aizman; Külliki Saar; Emelía Eiríksdóttir; Yang Jiang; Meeri Sassian; Pernilla Ostlund; Mattias Hällbrink; Ulo Langel
Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide.
Biochemical pharmacology 2006;71(4):416-25.
2006: Jennifer Zielinski; Kalle Kilk; Tiina Peritz; Theresa J Kannanayakal; Kevin Miyashiro; Emelía Eiríksdóttir; Jeanine Jochems; Ulo Langel; james eberwine
In vivo identification of ribonucleoprotein-RNA interactions.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1557-62.
2006: Tina Holm; Henrik Johansson; Pontus Lundberg; Margus Pooga; Maria Lindgren; Ulo Langel
Studying the uptake of cell-penetrating peptides.
Nature protocols 2006;1(2):1001-5.
2006: Fanyi Zeng; Tiina Peritz; Theresa J Kannanayakal; Kalle Kilk; Emelía Eiríksdóttir; Ulo Langel; james eberwine
A protocol for PAIR: PNA-assisted identification of RNA binding proteins in living cells.
Nature protocols 2006;1(2):920-7.
2006: Tiina Peritz; Fanyi Zeng; Theresa J Kannanayakal; Kalle Kilk; Emelía Eiríksdóttir; Ulo Langel; james eberwine
Immunoprecipitation of mRNA-protein complexes.
Nature protocols 2006;1(2):577-80.
2005: Samir El-Andaloussi; Henrik J Johansson; Audur Magnusdottir; Peter Järver; Pontus Lundberg; Ulo Langel
TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):189-201.
2005: Anders Florén; Ulla Sollenberg; Linda Lundström; Matjaz Zorko; Jure Stojan; Metka V Budihna; Mark Wheatley; Negin P Martin; Kalle Kilk; Andrey Mazarati; Tamas Bartfai; Maria Lindgren; Ulo Langel
Multiple interaction sites of galnon trigger its biological effects.
Neuropeptides 2005;39(6):547-58.
2005: Masaaki Sato; Dana S Hutchinson; Tore Bengtsson; Anders Floren; Ulo Langel; Takahiro Horinouchi; Bronwyn A Evans; Roger J Summers
Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1354-61.
2005: Kärt Padari; Pille Säälik; Mats Hansen; Kaida Koppel; Raivo Raid; Ulo Langel; Margus Pooga
Cell transduction pathways of transportans.
Bioconjugate chemistry 2005;16(6):1399-410.
2005: Külliki Saar; Maria Lindgren; Mats Hansen; Emelía Eiríksdóttir; Yang Jiang; Katri Rosenthal-Aizman; Meeri Sassian; Ulo Langel
Cell-penetrating peptides: a comparative membrane toxicity study.
Analytical biochemistry 2005;345(1):55-65.
2005: Tina Holm; Semharai Netzereab; Mats Hansen; Ulo Langel; Mattias Hällbrink
Uptake of cell-penetrating peptides in yeasts.
FEBS letters 2005;579(23):5217-22.
2005: Julie Parenteau; Roscoe Klinck; Liam Good; Ulo Langel; Raymund J Wellinger; Sherif Abou Elela
Free uptake of cell-penetrating peptides by fission yeast.
FEBS letters 2005;579(21):4873-8.
2005: Zoya Marinova; Vladana Vukojevic; Slavina Surcheva; Tatiana Yakovleva; Gvido Cebers; Natalia Pasikova; Ivan Usynin; Loïc Hugonin; Weijie Fang; Mathias Hallberg; Hirschberg Daniel; Tomas Bergman; Ulo Langel; Kurt F Hauser; Aladdin Pramanik; Jane V Aldrich; Astrid Gräslund; Lars Terenius; Georgy Bakalkin
Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission.
The Journal of biological chemistry 2005;280(28):26360-70.
2005: Annelie Ståhl; Stefan Nilsson; Pontus Lundberg; Shashi Bhushan; Henrik Biverståhl; Per Moberg; Magali Morisset; Alexander Vener; Lena Mäler; Ulo Langel; Elzbieta Glaser
Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different.
Journal of molecular biology 2005;349(4):847-60.
2005: Ariel Brewer; David J Echevarria; Ulo Langel; John K Robinson
Assessment of new functional roles for galanin in the CNS.
Neuropeptides 2005;39(3):323-6.
2005: Linda Lundström; Xiaoying Lu; Ulo Langel; Tamas Bartfai
Important pharmacophores for binding to galanin receptor 2.
Neuropeptides 2005;39(3):169-71.
2005: Ulla Sollenberg; Tamas Bartfai; Ulo Langel
Galnon--a low-molecular weight ligand of the galanin receptors.
Neuropeptides 2005;39(3):161-3.
2005: Xiaoying Lu; Linda Lundström; Ulo Langel; Tamas Bartfai
Galanin receptor ligands.
Neuropeptides 2005;39(3):143-6.
2005: Maarja Mäe; Helena Myrberg; Yang Jiang; Heiti Paves; Andres Valkna; Ulo Langel
Internalisation of cell-penetrating peptides into tobacco protoplasts.
Biochimica et biophysica acta 2005;1669(2):101-7.
2005: David J Echevarria; Ariel Brewer; Georgia Bushell; Honeyleen Manuzon; Ulo Langel; John K Robinson
Galanin and perseveration.
Brain research 2005;1041(2):143-8.
2005: Ariel Brewer; Ulo Langel; John K Robinson
Intracerebroventricular administration of galanin decreases free water intake and operant water reinforcer efficacy in water-restricted rats.
Neuropeptides 2005;39(2):117-24.
2005: Kalle Kilk; Samir El-Andaloussi; Peter Järver; Anne Meikas; Andres Valkna; Tamas Bartfai; Priit Kogerman; Madis Metsis; Ulo Langel
Evaluation of transportan 10 in PEI mediated plasmid delivery assay.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):511-23.
2005: Nguyen Thi Thu Quynh; Md Shahidul Islam; Shahidul Md Islam; Anders Florén; Tamas Bartfai; Ulo Langel; Claes-Göran Ostenson
Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets.
Biochemical and biophysical research communications 2005;328(1):213-20.
2005: Matjaz Zorko; Ulo Langel
Cell-penetrating peptides: mechanism and kinetics of cargo delivery.
Advanced drug delivery reviews 2005;57(4):529-45.
2005: Samir El-Andaloussi; Tina Holm; Ulo Langel
Cell-penetrating peptides: mechanisms and applications.
Current pharmaceutical design 2005;11(28):3597-611.
2005: Linda Lundström; Anna Elmquist; Tamas Bartfai; Ulo Langel
Galanin and its receptors in neurological disorders.
Neuromolecular medicine 2005;7(1-2):157-80.
2005: Ursel Soomets; Mihkel Zilmer; Ulo Langel
Manual solid-phase synthesis of glutathione analogs: a laboratory-based short course.
Methods in molecular biology (Clifton, N.J.) 2005;298():241-57.
2005: Kalle Kilk; Ulo Langel
Cellular delivery of peptide nucleic acid by cell-penetrating peptides.
Methods in molecular biology (Clifton, N.J.) 2005;298():131-41.
2005: Margus Pooga; Ulo Langel
Synthesis of cell-penetrating peptides for cargo delivery.
Methods in molecular biology (Clifton, N.J.) 2005;298():77-89.
2004: P Põder; Mihkel Zilmer; Joel Starkopf; Jaak Kals; A Talonpoika; Andres Pulges; Ulo Langel; Tiiu Kullisaar; Säde Viirlaid; Riina Mahlapuu; A Zarkovski; Andres Arend; Ursel Soomets
An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia.
Neuroscience letters 2004;370(1):45-50.
2004: Pille Säälik; Anna Elmquist; Mats Hansen; Kärt Padari; Külliki Saar; Kaido Viht; Ulo Langel; Margus Pooga
Protein cargo delivery properties of cell-penetrating peptides. A comparative study.
Bioconjugate chemistry 2004;15(6):1246-53.
2004: Ariel Brewer; Ulo Langel; John K Robinson
Intracerebroventricularly administered galanin does not alter operant reaction time or differentially reinforced high rate schedule operant responding in rats.
Neuroscience letters 2004;369(3):245-9.
2004: Kalle Kilk; Anna Elmquist; Külliki Saar; Margus Pooga; Tiit Land; Tamas Bartfai; Ursel Soomets; Ulo Langel
Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.
Neuropeptides 2004;38(5):316-24.
2004: L Fisher; Ursel Soomets; Veronica Cortés Toro; Lucy Chilton; Yang Jiang; Ulo Langel; Kerstin Iverfeldt
Cellular delivery of a double-stranded oligonucleotide NFkappaB decoy by hybridization to complementary PNA linked to a cell-penetrating peptide.
Gene therapy 2004;11(16):1264-72.
2004: Andrey Mazarati; Xiaoying Lu; Kalle Kilk; Ulo Langel; Claude Wasterlain; Tamas Bartfai
Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus.
The European journal of neuroscience 2004;19(12):3235-44.
2004: Peter Järver; Ulo Langel
The use of cell-penetrating peptides as a tool for gene regulation.
Drug discovery today 2004;9(9):395-402.
2004: Urho Abramov; Anders Florén; David J Echevarria; Ariel Brewer; Honeyleen Manuzon; John K Robinson; Tamas Bartfai; Eero Vasar; Ulo Langel
Regulation of feeding by galnon.
Neuropeptides 2004;38(1):55-61.
2004: Natalia Nekhotiaeva; Anna Elmquist; Gunaratna Kuttuva Rajarao; Mattias Hällbrink; Ulo Langel; Liam Good
Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):394-6.
2004: Xiao-Ying Hua; Carol S Hayes; Anthony Hofer; Bethany Fitzsimmons; Kalle Kilk; Ulo Langel; Tamas Bartfai; Tony L Yaksh
Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5.
The Journal of pharmacology and experimental therapeutics 2004;308(2):574-82.
2004: Maria Lindgren; Mattias Hällbrink; Anna Elmquist; Ulo Langel
Passage of cell-penetrating peptides across a human epithelial cell layer in vitro.
The Biochemical journal 2004;377(Pt 1):69-76.
2003: Wei-Ping Wu; Jing-Xia Hao; Linda Lundström; Zsuzsanna Wiesenfeld-Hallin; Ulo Langel; Tamas Bartfai; Xiao-Jun Xu
Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury.
European journal of pharmacology 2003;482(1-3):133-7.
2003: Riina Mahlapuu; Kaido Viht; Lajos Balaspiri; Nenad Bogdanovic; Külliki Saar; Ursel Soomets; Tiit Land; Mihkel Zilmer; Ello Karelson; Ulo Langel
Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain.
Brain research. Molecular brain research 2003;117(1):73-82.
2003: Pontus Lundberg; Ulo Langel
A brief introduction to cell-penetrating peptides.
Journal of molecular recognition : JMR 2003;16(5):227-33.
2003: Venetia Zachariou; Darlene H Brunzell; Jessica J Hawes; Diann R Stedman; Tamas Bartfai; Robert A Steiner; David Wynick; Ulo Langel; Marina R Picciotto
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):9028-33.
2003: Aljosa Bavec; Mattias Hällbrink; Ulo Langel; Matjaz Zorko
Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling.
Regulatory peptides 2003;111(1-3):137-44.
2003: Anna Elmquist; Ulo Langel
In vitro uptake and stability study of pVEC and its all-D analog.
Biological chemistry 2003;384(3):387-93.
2003: Linda Adlerz; Ursel Soomets; Linda Holmlund; Säde Viirlaid; Ulo Langel; Kerstin Iverfeldt
Down-regulation of amyloid precursor protein by peptide nucleic acid oligomer in cultured rat primary neurons and astrocytes.
Neuroscience letters 2003;336(1):55-9.
2003: Stephen G Howitt; Kalle Kilk; Yang Wang; David M Smith; Ulo Langel; David R Poyner
The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions.
British journal of pharmacology 2003;138(2):325-32.
2002: Pontus Lundberg; Mazin Magzoub; Mattias Lindberg; Mattias Hällbrink; Jüri Jarvet; L E G Eriksson; Ulo Langel; Astrid Gräslund
Cell membrane translocation of the N-terminal (1-28) part of the prion protein.
Biochemical and biophysical research communications 2002;299(1):85-90.
2002: Ello Karelson; Riina Mahlapuu; Mihkel Zilmer; Ursel Soomets; Nenad Bogdanovic; Ulo Langel
Possible signaling by glutathione and its novel analogue through potent stimulation of fontocortical G proteins in normal aging and in Alzheimer's disease.
Annals of the New York Academy of Sciences 2002;973():537-40.
2002: Alex C Conner; Debbie L Hay; Stephen G Howitt; Kalle Kilk; Ulo Langel; Mark Wheatley; David M Smith; David R Poyner
Interaction of calcitonin-gene-related peptide with its receptors.
Biochemical Society transactions 2002;30(4):451-5.
2002: Külliki Saar; Andrey Mazarati; Riina Mahlapuu; Gerd Hallnemo; Ursel Soomets; Kalle Kilk; Sven Hellberg; Margus Pooga; Bo-Ragnar Tolf; Tiejun S Shi; Tomas Hökfelt; Claude Wasterlain; Tamas Bartfai; Ulo Langel
Anticonvulsant activity of a nonpeptide galanin receptor agonist.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7136-41.
2002: Claes-Göran Ostenson; Ann-Christine Sandberg-Nordqvist; Jie Chen; Mattias Hällbrink; Daniela Rotin; Ulo Langel; Suad Efendic
Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats.
Biochemical and biophysical research communications 2002;291(4):945-50.
2002: Hironobu Suzuki; Toshihiko Iwanaga; Hiromasa Yoshie; Jun Li; Kaoru Yamabe; Noboru Yanaihara; Ulo Langel; Takeyasu Maeda
Expression of galanin receptor-1 (GALR1) in the rat trigeminal ganglia and molar teeth.
Neuroscience research 2002;42(3):197-207.
2002: Margus Pooga; Ursel Soomets; Tamas Bartfai; Ulo Langel
Synthesis of cell-penetrating peptide-PNA constructs.
Methods in molecular biology (Clifton, N.J.) 2002;208():225-36.
2002: Michelle Farquhar; Ursel Soomets; Ruth L Bates; Ashley Martin; Ulo Langel; John Howl
Novel mastoparan analogs induce differential secretion from mast cells.
Chemistry & biology 2002;9(1):63-70.
2001: V C Toro; Roya Tehranian; M Zetterström; G Eriksson; Ulo Langel; Tamas Bartfai; K Iverfeld
Increased gene expression of interleukin-1alpha and interleukin-6 in rat primary glial cells induced by beta-amyloid fragment.
Journal of molecular neuroscience : MN 2001;17(3):341-50.
2001: Andrey Mazarati; Ulo Langel; Tamas Bartfai
Galanin: an endogenous anticonvulsant?
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2001;7(6):506-17.
2001: Mattias Hällbrink; A Florén; Anna Elmquist; Margus Pooga; Tamas Bartfai; Ulo Langel
Cargo delivery kinetics of cell-penetrating peptides.
Biochimica et biophysica acta 2001;1515(2):101-9.
2001: Kalle Kilk; Mazin Magzoub; Margus Pooga; L E G Eriksson; Ulo Langel; Astrid Gräslund
Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide.
Bioconjugate chemistry 2001;12(6):911-6.
2001: Margus Pooga; C Kut; Madeleine Kihlmark; Mattias Hällbrink; Sandra Zetterström Fernaeus; Raivo Raid; Tiit Land; Einar Hallberg; Tamas Bartfai; Ulo Langel
Cellular translocation of proteins by transportan.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1451-3.
2001: Margus Pooga; Tiit Land; Tamas Bartfai; Ulo Langel
PNA oligomers as tools for specific modulation of gene expression.
Biomolecular engineering 2001;17(6):183-92.
2001: Tatiana Yakovleva; Aladdin Pramanik; T Kawasaki; Koichi Tan-No; Irina Gileva; Heléne Lindegren; Ulo Langel; T J Ekstrom; Rudolf Rigler; Lars Terenius; Georgy Bakalkin
p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.
The Journal of biological chemistry 2001;276(19):15650-8.
2001: Mazin Magzoub; Kalle Kilk; L E G Eriksson; Ulo Langel; Astrid Gräslund
Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles.
Biochimica et biophysica acta 2001;1512(1):77-89.
2001: Mattias Lindberg; Jüri Jarvet; Ulo Langel; Astrid Gräslund
Secondary structure and position of the cell-penetrating peptide transportan in SDS micelles as determined by NMR.
Biochemistry 2001;40(10):3141-9.
2001: Mattias Hällbrink; T Holmqvist; M Olsson; Claes-Göran Ostenson; Suad Efendic; Ulo Langel
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Biochimica et biophysica acta 2001;1546(1):79-86.
2001: K Rezaei; Isabella Shi Xu; Wei-Ping Wu; Tie-Jun Sten Shi; Ursel Soomets; Tiit Land; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; Tomas Hökfelt; Tamas Bartfai; Ulo Langel
Intrathecal administration of PNA targeting galanin receptor reduces galanin-mediated inhibitory effect in the rat spinal cord.
Neuroreport 2001;12(2):317-20.
2001: L Baláspiri; Ulo Langel
Synthesis of of beta-amyloid precursor peptide and presenilin segments.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(1):58-60.
2000: Maria Lindgren; X Gallet; Ursel Soomets; Mattias Hällbrink; Ebba Brakenhielm; Margus Pooga; Robert Brasseur; Ulo Langel
Translocation properties of novel cell penetrating transportan and penetratin analogues.
Bioconjugate chemistry 2000;11(5):619-26.
2000: Ursel Soomets; Maria Lindgren; X Gallet; Mattias Hällbrink; Anna Elmquist; Lajos Balaspiri; Matjaz Zorko; Margus Pooga; Robert Brasseur; Ulo Langel
Deletion analogues of transportan.
Biochimica et biophysica acta 2000;1467(1):165-76.
2000: Maria Lindgren; Mattias Hällbrink; A Prochiantz; Ulo Langel
Cell-penetrating peptides.
Trends in pharmacological sciences 2000;21(3):99-103.
2000: K Rezaei; Külliki Saar; Ursel Soomets; Andres Valkna; J Näsman; Matjaz Zorko; Karl E O Akerman; T Schroeder; Tamas Bartfai; Ulo Langel
Role of third intracellular loop of galanin receptor type 1 in signal transduction.
Neuropeptides 2000;34(1):25-31.
2000: Reet Kurg; Ulo Langel; Mart Ustav
Inhibition of the bovine papillomavirus E2 protein activity by peptide nucleic acid.
Virus research 2000;66(1):39-50.
1999: Ursel Soomets; Riina Mahlapuu; Roya Tehranian; Jüri Jarvet; Ello Karelson; Mihkel Zilmer; Kerstin Iverfeldt; Matjaz Zorko; Astrid Gräslund; Ulo Langel
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Brain research 1999;850(1-2):179-88.
1999: Ursel Soomets; Mattias Hällbrink; Ulo Langel
Antisense properties of peptide nucleic acids.
Frontiers in bioscience : a journal and virtual library 1999;4():D782-6.
1999: Mattias Hällbrink; Külliki Saar; Claes-Göran Ostenson; Ursel Soomets; Suad Efendic; John Howl; Mark Wheatley; Matjaz Zorko; Ulo Langel
Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity.
Regulatory peptides 1999;82(1-3):45-51.
1999: Reet Kurg; J Parik; E Juronen; T Sedman; Aare Abroi; I Liiv; Ulo Langel; Mart Ustav
Effect of bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA replication.
Journal of virology 1999;73(6):4670-7.
1999: Aljosa Bavec; Anders Juréus; B Cigić; Ulo Langel; Matjaz Zorko
Peptitergent PD1 affects the GTPase activity of rat brain cortical membranes.
Peptides 1999;20(2):177-84.
1998: Margus Pooga; Maria Lindgren; Mattias Hällbrink; Ebba Brakenhielm; Ulo Langel
Galanin-based peptides, galparan and transportan, with receptor-dependent and independent activities.
Annals of the New York Academy of Sciences 1998;863():450-3.
1998: Ulo Langel; Tamas Bartfai
Chemistry and molecular biology of galanin receptor ligands.
Annals of the New York Academy of Sciences 1998;863():86-93.
1998: K Kask; M Berthold; U Kahl; Anders Juréus; G Nordvall; Ulo Langel; Tamas Bartfai
Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding.
Annals of the New York Academy of Sciences 1998;863():78-85.
1998: Andrey Mazarati; Hantao Liu; Ursel Soomets; Raman Sankar; Don Shin; Hiroshi Katsumori; Ulo Langel; Claude Wasterlain
Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):10070-7.
1998: Anders Juréus; Maria Lindgren; Ulo Langel; Tamas Bartfai
Purification of a galanin degrading 70 kDa metallo-peptidase from bovine spinal cord.
Neuropeptides 1998;32(5):453-60.
1998: Margus Pooga; Ursel Soomets; Mattias Hällbrink; Andres Valkna; Külliki Saar; K Rezaei; U Kahl; Jing-Xia Hao; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; Tomas Hökfelt; Tamas Bartfai; Ulo Langel
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo.
Nature biotechnology 1998;16(9):857-61.
1998: David R Poyner; U Soomets; Stephen G Howitt; Ulo Langel
Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides.
British journal of pharmacology 1998;124(8):1659-66.
1998: CL Longland; M Mezna; Ulo Langel; Mattias Hällbrink; Ursel Soomets; Mark Wheatley; Francesco Michelangeli; John Howl
Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.
Cell calcium 1998;24(1):27-34.
1998: A Ohman; P O Lycksell; Anders Juréus; Ulo Langel; Tamas Bartfai; Astrid Gräslund
NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist.
Biochemistry 1998;37(25):9169-78.
1998: Ello Karelson; Ulo Langel
Galaninergic signalling and adenylate cyclase.
Neuropeptides 1998;32(3):197-210.
1998: Matjaz Zorko; Margus Pooga; Külliki Saar; K Rezaei; Ulo Langel
Differential regulation of GTPase activity by mastoparan and galparan.
Archives of biochemistry and biophysics 1998;349(2):321-8.
1998: Margus Pooga; Anders Juréus; K Razaei; H Hasanvan; Külliki Saar; K Kask; P Kjellén; Tiit Land; J Halonen; U Mäeorg; Asko Uri; S Solyom; Tamas Bartfai; Ulo Langel
Novel galanin receptor ligands.
The journal of peptide research : official journal of the American Peptide Society 1998;51(1):65-74.
1998: Margus Pooga; Mattias Hällbrink; Matjaz Zorko; Ulo Langel
Cell penetration by transportan.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(1):67-77.
1997: M Berthold; U Kahl; Anders Juréus; K Kask; G Nordvall; Ulo Langel; Tamas Bartfai
Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1.
European journal of biochemistry / FEBS 1997;249(2):601-6.
1997: M Mezna; Ulo Langel; Mattias Hällbrink; Mark Wheatley; Francesco Michelangeli; John Howl
Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.
Biochemical Society transactions 1997;25(3):450S.
1997: Külliki Saar; Andres Valkna; Ursel Soomets; K Rezaei; Matjaz Zorko; Mihkel Zilmer; Ulo Langel
Role of the third cytoplasmic loop in signal transduction by galanin receptors.
Biochemical Society transactions 1997;25(3):1036-40.
1997: John Howl; Ulo Langel; Stuart R Hawtin; Andres Valkna; NJ Yarwood; Külliki Saar; Mark Wheatley
Chimeric strategies for the rational design of bioactive analogs of small peptide hormones.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(7):582-90.
1997: Anders Juréus; Ulo Langel; Tamas Bartfai
L-Ala-substituted rat galanin analogs distinguish between hypothalamic and jejunal galanin receptor subtypes.
The journal of peptide research : official journal of the American Peptide Society 1997;49(3):195-200.
1996: L Grundemar; U Kahl; Torbjörn Callréus; Ulo Langel; Michael Bienert; M Beyermann
Ligand binding and functional effects of systematic double D-amino acid residue substituted neuropeptide Y analogs on Y1 and Y2 receptor types.
Regulatory peptides 1996;62(2-3):131-6.
1996: Ulo Langel; Margus Pooga; Ceslava Kairane; Mihkel Zilmer; Tamas Bartfai
A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Regulatory peptides 1996;62(1):47-52.
1996: A Ohman; R Davydov; B M Backlund; Ulo Langel; Astrid Gräslund
A study of melittin, motilin and galanin in reversed micellar environments, using circular dichroism spectroscopy.
Biophysical chemistry 1996;59(1-2):185-92.
1995: K Kask; Ulo Langel; Tamas Bartfai
Galanin--a neuropeptide with inhibitory actions.
Cellular and molecular neurobiology 1995;15(6):653-73.
1995: K Kask; M Berthold; J Bourne; S Andell; Ulo Langel; Tamas Bartfai
Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.
Regulatory peptides 1995;59(3):341-8.
1995: Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; Ulo Langel; K Bedecs; Tamas Bartfai
New high affinity peptide antagonists to the spinal galanin receptor.
British journal of pharmacology 1995;116(3):2076-80.
1995: K Bedecs; Ulo Langel; Tamas Bartfai
Metabolism of galanin and galanin (1-16) in isolated cerebrospinal fluid and spinal cord membranes from rat.
Neuropeptides 1995;29(3):137-43.
1995: M Zetterström; L Trogen; L G Hammarström; L Juhlin; B Nilsson; C Damberg; Tamas Bartfai; Ulo Langel
Synthesis of an N-methyldehydroalanine-containing fragment of microcystin by combination of solid phase peptide synthesis and beta-elimination in solution.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1995;49(9):696-700.
1995: A Ohman; PO Lycksell; S Andell; Ulo Langel; Tamas Bartfai; Astrid Gräslund
Solvent stabilized solution structures of galanin and galanin analogs, studied by circular dichroism spectroscopy.
Biochimica et biophysica acta 1995;1236(2):259-65.
1995: Xiao-Jun Xu; S Andell; X Zhang; Zsuzsanna Wiesenfeld-Hallin; Ulo Langel; K Bedecs; Tomas Hökfelt; Tamas Bartfai
Peripheral axotomy increases the expression of galanin message-associated peptide (GMAP) in dorsal root ganglion cells and alters the effects of intrathecal GMAP on the flexor reflex in the rat.
Neuropeptides 1995;28(5):299-307.
1995: Andres Valkna; Anders Juréus; Ello Karelson; Mihkel Zilmer; Tamas Bartfai; Ulo Langel
Differential regulation of adenylate cyclase activity in rat ventral and dorsal hippocampus by rat galanin.
Neuroscience letters 1995;187(2):75-8.
1994: S Gregersen; Ulo Langel; Tamas Bartfai; Bo Ahrén
N-terminally elongated fragments of galanin(1-16) inhibit insulin secretion from isolated mouse islets.
Regulatory peptides 1994;53(1):31-7.
1994: K Bedecs; Ulo Langel; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; Tamas Bartfai
Biological activities of two endogenously occurring N-terminally extended forms of galanin in the rat spinal cord.
European journal of pharmacology 1994;259(2):151-6.
1994: S Gregersen; Ulo Langel; Tamas Bartfai; Bo Ahrén
Galanin message-associated polypeptide (GMAP) does not affect insulin secretion from isolated islets.
European journal of pharmacology 1994;259(1):79-82.
1994: K Arvidsson; Ulo Langel; A Ehrenberg
Comparison of the solution structures of the chimeric peptides galanin(1-12)-Ala-neuropeptide Y(25-36)amide and galanin(1-12)-Pro-neuropeptide Y(25-36)amide.
European journal of biochemistry / FEBS 1994;222(2):573-81.
1994: C Rivera Baeza; K Kask; Ulo Langel; Tamas Bartfai; A Undén
Analogs of galanin (1-16) modified in positions 1-3 as ligands to rat hypothalamic galanin receptors.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1994;48(5):434-8.
1994: U Kahl; Ulo Langel; Tamas Bartfai; L Grundemar
Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types.
British journal of pharmacology 1994;111(4):1129-34.
1993: Tamas Bartfai; Ulo Langel; K Bedecs; S Andell; T Land; S Gregersen; Bo Ahrén; P Girotti; S Consolo; R Corwin
Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11287-91.
1993: A L Hulting; T Land; M Berthold; Ulo Langel; Tomas Hökfelt; Tamas Bartfai
Galanin receptors from human pituitary tumors assayed with human galanin as ligand.
Brain research 1993;625(1):173-6.
1993: S O Ogren; A Pramanik; T Land; Ulo Langel
Differential effects of the putative galanin receptor antagonists M15 and M35 on striatal acetylcholine release.
European journal of pharmacology 1993;242(1):59-64.
1993: K Arvidsson; T Land; Ulo Langel; Tamas Bartfai; A Ehrenberg
Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors.
Biochemistry 1993;32(30):7787-98.
1993: P Girotti; Rosalia Bertorelli; G Fisone; T Land; Ulo Langel; S Consolo; Tamas Bartfai
N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo.
Brain research 1993;612(1-2):258-62.
1993: S Gregersen; S Lindskog; T Land; Ulo Langel; Tamas Bartfai; Bo Ahrén
Blockade of galanin-induced inhibition of insulin secretion from isolated mouse islets by the non-methionine containing antagonist M35.
European journal of pharmacology 1993;232(1):35-9.
1993: Jacqueline N Crawley; J K Robinson; Ulo Langel; Tamas Bartfai
Galanin receptor antagonists M40 and C7 block galanin-induced feeding.
Brain research 1993;600(2):268-72.
1993: V M Verge; Xiao-Jun Xu; Ulo Langel; Tomas Hökfelt; Zsuzsanna Wiesenfeld-Hallin; Tamas Bartfai
Evidence for endogenous inhibition of autotomy by galanin in the rat after sciatic nerve section: demonstrated by chronic intrathecal infusion of a high affinity galanin receptor antagonist.
Neuroscience letters 1993;149(2):193-7.
1993: Tamas Bartfai; Tomas Hökfelt; Ulo Langel
Galanin--a neuroendocrine peptide.
Critical reviews in neurobiology 1993;7(3-4):229-74.
1992: S O Ogren; T Hökfelt; K Kask; Ulo Langel; Tamas Bartfai
Evidence for a role of the neuropeptide galanin in spatial learning.
Neuroscience 1992;51(1):1-5.
1992: Tomas Hökfelt; Katarina Aman; Ulf Arvidsson; K Bedecs; Sandra Ceccatelli; A L Hulting; Ulo Langel; Björn Meister; Vincent A Pieribone; Tamas Bartfai
Galanin message-associated peptide (GMAP)- and galanin-like immunoreactivities: overlapping and differential distributions in the rat.
Neuroscience letters 1992;142(2):139-42.
1992: Tamas Bartfai; G Fisone; Ulo Langel
Galanin and galanin antagonists: molecular and biochemical perspectives.
Trends in pharmacological sciences 1992;13(8):312-7.
1992: Ulo Langel; T Land; Tamas Bartfai
Design of chimeric peptide ligands to galanin receptors and substance P receptors.
International journal of peptide and protein research 1992;39(6):516-22.
1992: Zsuzsanna Wiesenfeld-Hallin; Xiao-Jun Xu; Ulo Langel; K Bedecs; Tomas Hökfelt; Tamas Bartfai
Galanin-mediated control of pain: enhanced role after nerve injury.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3334-7.
1992: K Bedecs; Ulo Langel; Tamas Bartfai; Zsuzsanna Wiesenfeld-Hallin
Galanin receptors and their second messengers in the lumbar dorsal spinal cord.
Acta physiologica Scandinavica 1992;144(3):213-20.
1992: S Lindskog; Bo Ahrén; T Land; Ulo Langel; Tamas Bartfai
The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion.
European journal of pharmacology 1992;210(2):183-8.
1992: J Laasik; Rannar Sillard; Ulo Langel; Mihkel Zilmer
Lipid-protein interactions in neurotropic Na-pump regulation.
Acta physiologica Scandinavica. Supplementum 1992;607():249-51.
1991: Tamas Bartfai; K Bedecs; T Land; Ulo Langel; Rosalia Bertorelli; P Girotti; S Consolo; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; S Nilsson
M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10961-5.
1991: S Gregersen; K Hermansen; Ulo Langel; G Fisone; Tamas Bartfai; Bo Ahrén
Galanin-induced inhibition of insulin secretion from rat islets: effects of rat and pig galanin and galanin fragments and analogues.
European journal of pharmacology 1991;203(1):111-4.
1991: T Land; Ulo Langel; Tamas Bartfai
Hypothalamic degradation of galanin(1-29) and galanin(1-16): identification and characterization of the peptidolytic products.
Brain research 1991;558(2):245-50.
1991: T Land; Ulo Langel; M Löw; M Berthold; A Undén; Tamas Bartfai
Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor.
International journal of peptide and protein research 1991;38(3):267-72.
1991: Rannar Sillard; Ulo Langel; Hans Jörnvall
Isolation and characterization of galanin from sheep brain.
Peptides 1991;12(4):855-9.
1990: Jacqueline N Crawley; M C Austin; S M Fiske; B Martin; S Consolo; M Berthold; Ulo Langel; G Fisone; Tamas Bartfai
Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(11):3695-700.
1989: G Fisone; Ulo Langel; M Carlquist; T Bergman; S Consolo; Tomas Hökfelt; A Undén; S Andell; Tamas Bartfai
Galanin receptor and its ligands in the rat hippocampus.
European journal of biochemistry / FEBS 1989;181(1):269-76.