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Ralf Langen

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Procedures

Electron Spin Resonance Spectroscopy

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Publications

TOP 3
Safia Costes; Tatyana Gurlo; Ralf Langen; Aleksey V Matveyenko; Peter C Butler
β-Cell failure in type 2 diabetes: a case of asking too much of too few?
Yiyu Li; Ralf Langen; Ma'mon M Hatmal; Ian S Haworth
Idealized models of protofilaments of human islet amyloid polypeptide.
Chun-Liang Lai; Ralf Langen; Edward Lyman; Harvey T McMahon; Brian J Peter; Jennifer L Gallop; Christine C Jao; Gregory A Voth
Membrane binding and self-association of the epsin N-terminal homology domain.

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All Publications

2013: Safia Costes; Tatyana Gurlo; Ralf Langen; Aleksey V Matveyenko; Peter C Butler
β-Cell failure in type 2 diabetes: a case of asking too much of too few?
Diabetes 2013;62(2):327-35.
2012: Yiyu Li; Ralf Langen; Ma'mon M Hatmal; Ian S Haworth
Idealized models of protofilaments of human islet amyloid polypeptide.
Journal of chemical information and modeling 2012;52(11):2983-91.
2012: Chun-Liang Lai; Ralf Langen; Edward Lyman; Harvey T McMahon; Brian J Peter; Jennifer L Gallop; Christine C Jao; Gregory A Voth
Membrane binding and self-association of the epsin N-terminal homology domain.
Journal of molecular biology 2012;423(5):800-17.
2012: Charles W Bugg; Torsten Fischer; J Mario Isas; Paul H Patterson; Ralf Langen
Structural features and domain organization of huntingtin fibrils.
The Journal of biological chemistry 2012;287(38):31739-46.
2012: Naoko Mizuno; Jobin Varkey; Naiqian Cheng; Balachandra G Hegde; Natalie C Kegulian; Ralf Langen; Alasdair C Steven
Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.
The Journal of biological chemistry 2012;287(35):29301-11.
2012: Franziska Meier; Jobin Varkey; Tharindumala Abeywardana; Champak Chatterjee; Abhinav Dhall; Ralf Langen; Nicholas P Marotta; Matthew R Pratt
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.
Journal of the American Chemical Society 2012;134(12):5468-71.
2012: Sahar Bedrood; Ian S Haworth; Balachandra G Hegde; J Mario Isas; Ulrich Baxa; Yiyu Li; Ralf Langen
Fibril structure of human islet amyloid polypeptide.
The Journal of biological chemistry 2012;287(8):5235-41.
2012: Venkatramanan Krishnamani; Ralf Langen; Balachandra G Hegde; Janos K Lanyi
Secondary and tertiary structure of bacteriorhodopsin in the SDS denatured state.
Biochemistry 2012;51(6):1051-60.
2012: Andrew W Woodham; Ralf Langen; Adam B Raff; Joseph G Skeate; Mark R Ambroso; Heike E Brand; Diane M Da Silva; J Mario Isas; W Martin Kast
The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection.
PloS one 2012;7(8):e43519.
2012: Ma'mon M Hatmal; Balachandra G Hegde; Prabhavati B Hegde; Christine C Jao; Ralf Langen; Yiyu Li; Ian S Haworth
Computer modeling of nitroxide spin labels on proteins.
Biopolymers 2012;97(1):35-44.
2011: Martin Borch Jensen; Ralf Langen; Søren L Pedersen; Jakob Ewald Rasmussen; Vikram Kjøller Bhatia; Christine C Jao; Knud J Jensen; Dimitrios Stamou
Membrane curvature sensing by amphipathic helices: a single liposome study using α-synuclein and annexin B12.
The Journal of biological chemistry 2011;286(49):42603-14.
2011: Qi Charles Zhang; Tzu-lan Yeh; Alfonso Leyva; Leslie G Frank; Jason Miller; Yujin E Kim; Ralf Langen; Steven Finkbeiner; Mario Amzel; Christopher A Ross; Michelle A Poirier
A compact beta model of huntingtin toxicity.
The Journal of biological chemistry 2011;286(10):8188-96.
2010: Jobin Varkey; J Mario Isas; Naoko Mizuno; Martin Borch Jensen; Vikram Kjøller Bhatia; Christine C Jao; Jitka Petrlova; John C Voss; Dimitrios G Stamou; Alasdair C Steven; Ralf Langen
Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.
The Journal of biological chemistry 2010;285(42):32486-93.
2010: Marie Daval; Sahar Bedrood; Tatyana Gurlo; Chang-Jiang Huang; Safia Costes; Peter C Butler; Ralf Langen
The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2010;17(3-4):118-28.
2010: Yujin E Kim; Jeannie Chen; Ralf Langen; Jonah R Chan
Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis.
Nature protocols 2010;5(8):1396-405.
2010: Jampani Nageswara Rao; Christine C Jao; Balachandra G Hegde; Ralf Langen; Tobias S Ulmer
A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins.
Journal of the American Chemical Society 2010;132(25):8657-68.
2010: Christine C Jao; Balachandra G Hegde; Jennifer L Gallop; Prabhavati B Hegde; Harvey T McMahon; Ian S Haworth; Ralf Langen
Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation.
The Journal of biological chemistry 2010;285(26):20164-70.
2010: J Mario Isas; Volker Luibl; Lincoln V Johnson; Rakez Kayed; Ronald Wetzel; Charles G Glabe; Ralf Langen; Jeannie Chen
Soluble and mature amyloid fibrils in drusen deposits.
Investigative ophthalmology & visual science 2010;51(3):1304-10.
2010: Jessica W Wu; Leonid Breydo; J Mario Isas; Jerome Lee; Yurii G Kuznetsov; Ralf Langen; Charles G Glabe
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.
The Journal of biological chemistry 2010;285(9):6071-9.
2010: Yujin E Kim; Jeannie Chen; Jonah R Chan; Ralf Langen
Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration.
Nature methods 2010;7(1):67-73.
2009: Sahar Bedrood; Sajith Jayasinghe; Derek Sieburth; Min Chen; Saskia Erbel; Peter C Butler; Ralf Langen; Robert A Ritzel
Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.
Biochemistry 2009;48(44):10568-76.
2008: Melania Apostolidou; Sajith A Jayasinghe; Ralf Langen
Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.
The Journal of biological chemistry 2008;283(25):17205-10.
2008: Thuzar M Shin; J Mario Isas; Chia-Ling Hsieh; Rakez Kayed; Charles G Glabe; Ralf Langen; Jeannie Chen
Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.
Molecular neurodegeneration 2008;3():16.
2007: Min Chen; Martin Margittai; Jeannie Chen; Ralf Langen
Investigation of alpha-synuclein fibril structure by site-directed spin labeling.
The Journal of biological chemistry 2007;282(34):24970-9.
2007: Sajith A Jayasinghe; Ralf Langen
Membrane interaction of islet amyloid polypeptide.
Biochimica et biophysica acta 2007;1768(8):2002-9.
2007: William Mike Henne; Helen M Kent; Marijn G J Ford; Balachandra G Hegde; Oliver Daumke; P Jonathan G Butler; Rohit Mittal; Ralf Langen; Philip R Evans; Harvey T McMahon
Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.
Structure (London, England : 1993) 2007;15(7):839-52.
2007: Torsten Fischer; Lucy Lu; Harry T Haigler; Ralf Langen
Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes.
The Journal of biological chemistry 2007;282(13):9996-10004.
2006: Martin Margittai; Ralf Langen
Side chain-dependent stacking modulates tau filament structure.
The Journal of biological chemistry 2006;281(49):37820-7.
2006: Juris J Meier; Rakez Kayed; Chia-Yu Lin; Tatyana Gurlo; Leena Haataja; Sajith A Jayasinghe; Ralf Langen; Charles G Glabe; Peter C Butler
Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1317-24.
2006: Jennifer L Gallop; Christine C Jao; Helen M Kent; P Jonathan G Butler; Philip R Evans; Ralf Langen; Harvey T McMahon
Mechanism of endophilin N-BAR domain-mediated membrane curvature.
The EMBO journal 2006;25(12):2898-910.
2006: Volker Luibl; J Mario Isas; Rakez Kayed; Charles G Glabe; Ralf Langen; Jeannie Chen
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.
The Journal of clinical investigation 2006;116(2):378-85.
2006: Balachandra G Hegde; J Mario Isas; Guido A Zampighi; Harry T Haigler; Ralf Langen
A novel calcium-independent peripheral membrane-bound form of annexin B12.
Biochemistry 2006;45(3):934-42.
2006: Martin Margittai; Ralf Langen
Spin labeling analysis of amyloids and other protein aggregates.
Methods in enzymology 2006;413():122-39.
2005: J Mario Isas; Yujin E Kim; Christine C Jao; Prabhavati B Hegde; Harry T Haigler; Ralf Langen
Calcium- and membrane-induced changes in the structure and dynamics of three helical hairpins in annexin B12.
Biochemistry 2005;44(50):16435-44.
2005: Yujin E Kim; J Mario Isas; Harry T Haigler; Ralf Langen
A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH.
The Journal of biological chemistry 2005;280(37):32398-404.
2005: Sajith A Jayasinghe; Ralf Langen
Lipid membranes modulate the structure of islet amyloid polypeptide.
Biochemistry 2005;44(36):12113-9.
2005: Sathees C Raghavan; Paul Chastain; Jeremy S Lee; Balachandra G Hegde; Sabrina Houston; Ralf Langen; Chih-Lin Hsieh; Ian S Haworth; Michael R Lieber
Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation.
The Journal of biological chemistry 2005;280(24):22749-60.
2005: Darshana R Patel; J Mario Isas; Alexey S Ladokhin; Christine C Jao; Yujin E Kim; Thorsten Kirsch; Ralf Langen; Harry T Haigler
The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties.
Biochemistry 2005;44(8):2833-44.
2004: Sajith A Jayasinghe; Ralf Langen
Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling.
The Journal of biological chemistry 2004;279(46):48420-5.
2004: Sathees C Raghavan; Sabrina Houston; Balachandra G Hegde; Ralf Langen; Ian S Haworth; Michael R Lieber
Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region.
The Journal of biological chemistry 2004;279(44):46213-25.
2004: J Mario Isas; Ralf Langen; Wayne L Hubbell; Harry T Haigler
Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12.
The Journal of biological chemistry 2004;279(31):32492-8.
2004: Martin Margittai; Ralf Langen
Template-assisted filament growth by parallel stacking of tau.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10278-83.
2004: Christine C Jao; Ani Der-Sarkissian; Jeannie Chen; Ralf Langen
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8331-6.
2003: Ani Der-Sarkissian; Christine C Jao; Jeannie Chen; Ralf Langen
Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling.
The Journal of biological chemistry 2003;278(39):37530-5.
2003: J Mario Isas; Darshana R Patel; Christine C Jao; Sajith A Jayasinghe; Jean-Philippe Cartailler; Harry T Haigler; Ralf Langen
Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH.
The Journal of biological chemistry 2003;278(32):30227-34.
2003: Martin Margittai; Dirk Fasshauer; Reinhard Jahn; Ralf Langen
The Habc domain and the SNARE core complex are connected by a highly flexible linker.
Biochemistry 2003;42(14):4009-14.
2002: Marianna Török; Saskia Milton; Rakez Kayed; Peng Wu; Theresa M McIntire; Charles G Glabe; Ralf Langen
Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.
The Journal of biological chemistry 2002;277(43):40810-5.
2002: Stefan Pabst; Martin Margittai; Darius Vainius; Ralf Langen; Reinhard Jahn; Dirk Fasshauer
Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.
The Journal of biological chemistry 2002;277(10):7838-48.
2002: J Mario Isas; Ralf Langen; Harry T Haigler; Wayne L Hubbell
Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study.
Biochemistry 2002;41(5):1464-73.
2001: Darshana R Patel; Christine C Jao; WS Mailliard; J Mario Isas; Ralf Langen; Harry T Haigler
Calcium-dependent binding of annexin 12 to phospholipid bilayers: stoichiometry and implications.
Biochemistry 2001;40(24):7054-60.
2001: Martin Margittai; Dirk Fasshauer; Stefan Pabst; Reinhard Jahn; Ralf Langen
Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling.
The Journal of biological chemistry 2001;276(16):13169-77.
2000: Ralf Langen; KJ Oh; Duilio Cascio; Wayne L Hubbell
Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure.
Biochemistry 2000;39(29):8396-405.
2000: J Mario Isas; Jean-Philippe Cartailler; Yuri Sokolov; Darshana R Patel; Ralf Langen; Hartmut Luecke; James E Hall; Harry T Haigler
Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels.
Biochemistry 2000;39(11):3015-22.
1999: Ralf Langen; K Cai; Christian Altenbach; H Gobind Khorana; Wayne L Hubbell
Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study.
Biochemistry 1999;38(25):7918-24.
1998: Ralf Langen; J Mario Isas; Wayne L Hubbell; Harry T Haigler
A transmembrane form of annexin XII detected by site-directed spin labeling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14060-5.
1998: Wayne L Hubbell; Adrian Gross; Ralf Langen; Michael A Lietzow
Recent advances in site-directed spin labeling of proteins.
Current opinion in structural biology 1998;8(5):649-56.
1998: Ralf Langen; J Mario Isas; Hartmut Luecke; Harry T Haigler; Wayne L Hubbell
Membrane-mediated assembly of annexins studied by site-directed spin labeling.
The Journal of biological chemistry 1998;273(35):22453-7.
1997: K Cai; Ralf Langen; Wayne L Hubbell; H Gobind Khorana
Structure and function in rhodopsin: topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14267-72.