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Robert Langenbach
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Chemicals & Drugs
Living Beings
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17
Tiano, Howard
15
Morham, Scott
12
Loftin, Charles
10
Chulada, Patricia
8
Lee, Christopher
8
Smithies, Oliver
7
Zeldin, Darryl
6
Nesnow, Stephen
5
Penman, Bruce
5
Akunda, Jacqueline
4
Chun, Kyung-Soo
4
Bradbury, Alyce
4
Breyer, Matthew
4
Sessoms, Alisha
3
Trivedi, Darshini
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All Publications
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2009: Chun Kyung-Soo; Lao Huei-Chen; Trempus Carol S; Okada Manabu; Langenbach Robert
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
Carcinogenesis 2009;30(9):1620-7.
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2009: Iguchi Genzo; Chrysovergis Kali; Lee Seong-Ho; Baek Seung Joon; Langenbach Robert; Eling Thomas E
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.
Cancer letters 2009;282(2):152-8.
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2009: Zhang Dan; Hu Xiaoming; Qian Li; Wilson Belinda; Lee Christopher; Flood Patrick; Langenbach Robert; Hong Jau-Shyong
Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.
Toxicology and applied pharmacology 2009;238(1):64-70.
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2007: Chun Kyung-Soo; Langenbach Robert
A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin.
Molecular carcinogenesis 2007;46(8):699-704.
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2007: Akunda Jacqueline K; Chun Kyung-Soo; Sessoms Alisha R; Lao Huei-Chen; Fischer Susan M; Langenbach Robert
Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure.
Molecular carcinogenesis 2007;46(5):354-62.
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2007: Chun Kyung-Soo; Akunda Jacqueline K; Langenbach Robert
Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4.
Cancer research 2007;67(5):2015-21.
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2007: Gitlin Jonathan M; Trivedi Darshini B; Langenbach Robert; Loftin Charles D
Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice.
Cardiovascular research 2007;73(1):227-36.
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2005: Carey Michelle A; Bradbury J Alyce; Seubert John M; Langenbach Robert; Zeldin Darryl C; Germolec Dori R
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6878-84.
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2005: Wang Tongguang; Pei Zhong; Zhang Wei; Liu Bin; Langenbach Robert; Lee Christopher; Wilson Belinda; Reece Jeffrey M; Miller David S; Hong Jau-Shyong
MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1134-6.
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2004: Wormser Uri; Langenbach Robert; Peddada Shyamal; Sintov Amnon; Brodsky Berta; Nyska Abraham
Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice.
Toxicology and applied pharmacology 2004;200(1):40-7.
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2004: Schneider André; Guan YouFei; Zhang Yahua; Magnuson Mark A; Pettepher Cathy; Loftin Charles D; Langenbach Robert; Breyer Richard M; Breyer Matthew D
Generation of a conditional allele of the mouse prostaglandin EP4 receptor.
Genesis (New York, N.Y. : 2000) 2004;40(1):7-14.
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2004: Gray Thomas; Nettesheim Paul; Loftin Charles; Koo Ja-Seok; Bonner James; Peddada Shyamal; Langenbach Robert
Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.
Molecular pharmacology 2004;66(2):337-46.
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2004: Goulet Jennifer L; Pace Amy J; Key Mikelle L; Byrum Robert S; Nguyen MyTrang; Tilley Stephen L; Morham Scott G; Langenbach Robert; Stock Jeffrey L; McNeish John D; Smithies Oliver; Coffman Thomas M; Koller Beverly H
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1321-6.
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2004: Darling Rebecca L; Romero Jimmy J; Dial Elizabeth J; Akunda Jacqueline K; Langenbach Robert; Lichtenberger Lenard M
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice.
Gastroenterology 2004;127(1):94-104.
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2004: Wang Tongguang; Qin Liya; Liu Bin; Liu Yuxin; Wilson Belinda; Eling Thomas E; Langenbach Robert; Taniura Seijiro; Hong Jau-Shyong
Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia.
Journal of neurochemistry 2004;88(4):939-47.
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2004: Akunda Jacqueline K; Lao Huei-Chen; Lee Chris A; Sessoms Alisha R; Slade Rachel M; Langenbach Robert
Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):185-7.
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2003: Takeda Haruna; Sonoshita Masahiro; Oshima Hiroko; Sugihara Ken-ichi; Chulada Patricia C; Langenbach Robert; Oshima Masanobu; Taketo Makoto M
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Cancer research 2003;63(16):4872-7.
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2003: Carey Michelle A; Germolec Dori R; Langenbach Robert; Zeldin Darryl C
Cyclooxygenase enzymes in allergic inflammation and asthma.
Prostaglandins, leukotrienes, and essential fatty acids 2003;69(2-3):157-62.
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2003: Carey Michelle A; Germolec Dori R; Bradbury J Alyce; Gooch Rebecca A; Moorman Michael P; Flake Gordon P; Langenbach Robert; Zeldin Darryl C
Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice.
American journal of respiratory and critical care medicine 2003;167(11):1509-15.
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2002: Loftin Charles D; Tiano Howard F; Langenbach Robert
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.
Prostaglandins & other lipid mediators 2002;68-69():177-85.
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2002: Loftin Charles D; Trivedi Darshini B; Langenbach Robert
Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus.
The Journal of clinical investigation 2002;110(4):549-57.
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2002: Bonner James C; Rice Annette B; Ingram Jennifer L; Moomaw Cindy R; Nyska Abraham; Bradbury Alyce; Sessoms Alisha R; Chulada Patricia C; Morgan Daniel L; Zeldin Darryl C; Langenbach Robert
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
The American journal of pathology 2002;161(2):459-70.
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2002: Qi Zhonghua; Hao Chuan-Ming; Langenbach Robert I; Breyer Richard M; Redha Reyadh; Morrow Jason D; Breyer Matthew D
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.
The Journal of clinical investigation 2002;110(1):61-9.
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2002: Tiano Howard F; Loftin Charles D; Akunda Jackie; Lee Christopher A; Spalding Judson; Sessoms Alisha; Dunson David B; Rogan Eleanor G; Morham Scott G; Smart Robert C; Langenbach Robert
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
Cancer research 2002;62(12):3395-401.
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2001: Camitta M G; Gabel S A; Chulada P; Bradbury J A; Langenbach R; Zeldin D C; Murphy E
Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
Circulation 2001;104(20):2453-8.
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2001: Zeldin D C; Wohlford-Lenane C; Chulada P; Bradbury J A; Scarborough P E; Roggli V; Langenbach R; Schwartz D A
Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.
American journal of respiratory cell and molecular biology 2001;25(4):457-65.
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2001: Zhang X; Morham S G; Langenbach R; Young D A; Xing L; Boyce B F; Puzas E J; Rosier R N; O'Keefe R J; Schwarz E M
Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):660-70.
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2001: Wang H Q; Kim M P; Tiano H F; Langenbach R; Smart R C
Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes.
Molecular pharmacology 2001;59(4):860-6.
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2001: Loftin C D; Trivedi D B; Tiano H F; Clark J A; Lee C A; Epstein J A; Morham S G; Breyer M D; Nguyen M; Hawkins B M; Goulet J L; Smithies O; Koller B H; Langenbach R
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1059-64.
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2000: Chulada P C; Thompson M B; Mahler J F; Doyle C M; Gaul B W; Lee C; Tiano H F; Morham S G; Smithies O; Langenbach R
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.
Cancer research 2000;60(17):4705-8.
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2000: Morteau O; Morham S G; Sellon R; Dieleman L A; Langenbach R; Smithies O; Sartor R B
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.
The Journal of clinical investigation 2000;105(4):469-78.
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2000: Kömhoff M; Wang J L; Cheng H F; Langenbach R; McKanna J A; Harris R C; Breyer M D
Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development.
Kidney international 2000;57(2):414-22.
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2000: Zhang X; Morham S G; Langenbach R; Baggs R B; Young D A
Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice.
Experimental cell research 2000;254(2):232-40.
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1999: Reddy S T; Tiano H F; Langenbach R; Morham S G; Herschman H R
Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells.
Biochemical and biophysical research communications 1999;265(1):205-10.
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1999: Langenbach R; Loftin C; Lee C; Tiano H
Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.
Biochemical pharmacology 1999;58(8):1237-46.
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1999: Gavett S H; Madison S L; Chulada P C; Scarborough P E; Qu W; Boyle J E; Tiano H F; Lee C A; Langenbach R; Roggli V L; Zeldin D C
Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
The Journal of clinical investigation 1999;104(6):721-32.
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1999: Zhang X; Morham S G; Langenbach R; Young D A
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
The Journal of experimental medicine 1999;190(4):451-59.
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1999: Davis B J; Lennard D E; Lee C A; Tiano H F; Morham S G; Wetsel W C; Langenbach R
Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.
Endocrinology 1999;140(6):2685-95.
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1999: Langenbach R; Loftin C D; Lee C; Tiano H
Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.
Annals of the New York Academy of Sciences 1999;889():52-61.
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1997: Chulada P C; Langenbach R
Differential inhibition of murine prostaglandin synthase-1 and -2 by nonsteroidal anti-inflammatory drugs using exogenous and endogenous sources of arachidonic acid.
The Journal of pharmacology and experimental therapeutics 1997;280(2):606-13.
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1997: Morham S G; Langenbach R; Mahler J; Smithies O
Characterization of prostaglandin H synthase 2 deficient mice and implications for mechanisms of NSAID action.
Advances in experimental medicine and biology 1997;407():131-8.
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1997: Langenbach R; Morham S G; Tiano H F; Loftin C D; Ghanayem B I; Chulada P C; Mahler J F; Davis B J; Lee C A
Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.
Advances in experimental medicine and biology 1997;407():87-92.
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1996: Mahler J F; Davis B J; Morham S G; Langenbach R
Disruption of cyclooxygenase genes in mice.
Toxicologic pathology 1996;24(6):717-9.
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1995: Langenbach R; Morham S G; Tiano H F; Loftin C D; Ghanayem B I; Chulada P C; Mahler J F; Lee C A; Goulding E H; Kluckman K D; Kim H S; Smithies O
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Cell 1995;83(3):483-92.
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1995: Morham S G; Langenbach R; Loftin C D; Tiano H F; Vouloumanos N; Jennette J C; Mahler J F; Kluckman K D; Ledford A; Lee C A; Smithies O
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.
Cell 1995;83(3):473-82.
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1995: Smith P B; Tiano H F; Nesnow S; Boyd M R; Philpot R M; Langenbach R
4-Ipomeanol and 2-aminoanthracene cytotoxicity in C3H/10T1/2 cells expressing rabbit cytochrome P450 4B1.
Biochemical pharmacology 1995;50(10):1567-75.
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1994: Tiano H F; Wang R L; Hosokawa M; Crespi C; Tindall K R; Langenbach R
Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
Carcinogenesis 1994;15(12):2859-66.
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1994: Detloff P J; Lewis J; John S W; Shehee W R; Langenbach R; Maeda N; Smithies O
Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.
Molecular and cellular biology 1994;14(10):6936-43.
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1994: Nesnow S; Beck S; Rosenblum S; Lasley J; Tiano H F; Hosokawa M; Crespi C L; Langenbach R
N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P450 2A6.
Mutation research 1994;324(3):93-102.
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1993: Crespi C L; Penman B W; Gonzalez F J; Gelboin H V; Galvin M; Langenbach R
Genetic toxicology using human cell lines expressing human P-450.
Biochemical Society transactions 1993;21(4):1023-8.
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1993: Crespi C L; Langenbach R; Penman B W
Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.
Toxicology 1993;82(1-3):89-104.
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1993: Tiano H F; Hosokawa M; Chulada P C; Smith P B; Wang R L; Gonzalez F J; Crespi C L; Langenbach R
Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis 1993;14(7):1421-7.
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1992: Langenbach R; Smith P B; Crespi C
Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology.
Mutation research 1992;277(3):251-75.
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1991: Crespi C L; Gonzalez F J; Steimel D T; Turner T R; Gelboin H V; Penman B W; Langenbach R
A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing.
Chemical research in toxicology 1991;4(5):566-72.
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1991: Abu-Shakra A; Johnson L; Earley K; Jameson C W; Kari F W; Gupta R; Langenbach R
Isolation of the mutagenic and DNA adduct-inducing components from a commercial preparation of HC blue 1 using Salmonella (TA98) bioassay-directed HPLC fractionation.
Mutation research 1991;260(4):377-85.
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1990: Kari F W; Driscoll S M; Abu-Shakra A; Strom S C; Jenkins W L; Volosin J S; Rudo K M; Langenbach R
Comparative metabolism and genotoxicity of the structurally similar nitrophenylenediamine dyes, HC Blue 1 and HC Blue 2, in mouse hepatocytes.
Cell biology and toxicology 1990;6(2):139-55.
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1990: Innes C L; Smith P B; Langenbach R; Tindall K R; Boone L R
Cationic liposomes (Lipofectin) mediate retroviral infection in the absence of specific receptors.
Journal of virology 1990;64(2):957-61.
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1990: Crespi C L; Langenbach R; Penman B W
The development of a panel of human cell lines expressing specific human cytochrome P450 cDNAs.
Progress in clinical and biological research 1990;340B():97-106.
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1990: Kari F; Driscoll S; Parker C; Rudo K; Tomer K; Langenbach R
Species comparisons regarding comparative metabolism of two structurally similar phenylenediamines (HC Blue 1 and HC Blue 2).
Progress in clinical and biological research 1990;340D():305-14.
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1990: Langenbach R; Crespi C; Davies R; Rudo K; Smith P; Hansen S; Ross J; Siegfried J; Nesnow S
Transfection of cytochrome P450 cDNAs into mammalian cells used in mutation and transformation assays.
Progress in clinical and biological research 1990;340D():239-48.
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1990: Mason J M; Langenbach R; Shelby M D; Zeiger E; Tennant R W
Ability of short-term tests to predict carcinogenesis in rodents.
Annual review of pharmacology and toxicology 1990;30():149-68.
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1989: Davies R L; Crespi C L; Rudo K; Turner T R; Langenbach R
Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens.
Carcinogenesis 1989;10(5):885-91.
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1989: Rudo K M; Dauterman W C; Langenbach R
Human and rat kidney cell metabolism of 2-acetylaminofluorene and benzo(a)pyrene.
Cancer research 1989;49(5):1187-92.
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1989: Crespi C L; Langenbach R; Rudo K; Chen Y T; Davies R L
Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays.
Carcinogenesis 1989;10(2):295-301.
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1989: Hansen S K; Ross J A; Siegfried J M; Leavitt S; Rudo K; Langenbach R; Nesnow S
Transfection of a rat cytochrome P450b cDNA into C3H10T1/2CL8 mouse embryo fibroblasts.
Molecular carcinogenesis 1989;2(5):261-7.
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1988: Langenbach R; Rudo K
Human hepatocyte and kidney cell metabolism of 2-acetylaminofluorene and comparison to the respective rat cells.
Cell biology and toxicology 1988;4(4):453-65.
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1988: Caspary W J; Langenbach R; Penman B W; Crespi C; Myhr B C; Mitchell A D
The mutagenic activity of selected compounds at the TK locus: rodent vs. human cells.
Mutation research 1988;196(1):61-81.
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1987: Rudo K; Meyers W C; Dauterman W; Langenbach R
Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.
Cancer research 1987;47(22):5861-7.
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1987: Langenbach R; Rudo K; Ellis S; Hix C; Nesnow S
Species variation in bladder cell and liver cell activation of acetylaminofluorene.
Cell biology and toxicology 1987;3(3):303-19.
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1986: Langenbach R; Leavitt S; Hix C; Sharief Y; Allen J W
Rat and hamster hepatocyte-mediated induction of SCEs and mutation in V79 cells and mutation of salmonella by aminofluorene and dimethylnitrosamine.
Mutation research 1986;161(1):29-37.
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1984: Sharief Y; Campbell J; Leavitt S; Langenbach R; Allen J W
Rodent species and strain specificities for sister-chromatid exchange induction and gene mutagenesis effects from ethyl carbamate, ethyl N-hydroxycarbamate, and vinyl carbamate.
Mutation research 1984;126(2):159-67.
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1983: Hix C; Oglesby L; MacNair P; Sieg M; Langenbach R
Bovine bladder and liver cell and homogenate-mediated mutagenesis of Salmonella typhimurium with aromatic amines.
Carcinogenesis 1983;4(11):1401-7.
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1983: Oglesby L A; Hix C; Snow L; MacNair P; Seig M; Langenbach R
Bovine bladder urothelial cell activation of carcinogens to metabolites mutagenic to Chinese hamster V79 cells and Salmonella typhimurium.
Cancer research 1983;43(11):5194-9.
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1983: Allen J W; Sharief Y; Langenbach R; Waters M D
Tissue-specific sister chromatid exchange analyses in mutagen-carcinogen exposed animals.
Basic life sciences 1983;24():451-72.
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1983: Langenbach R; Hix C; Oglesby L; Allen J
Cell-mediated mutagenesis of Chinese hamster V79 cells and Salmonella typhimurium.
Annals of the New York Academy of Sciences 1983;407():258-66.
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1982: Allen J W; Langenbach R; Nesnow S; Sasseville K; Leavitt S; Campbell J; Brock K; Sharief Y
Comparative genotoxicity studies of ethyl carbamate and related chemicals: further support for vinyl carbamate as a proximate carcinogenic metabolite.
Carcinogenesis 1982;3(12):1437-41.
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