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Mark Lanigan

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Mark D Lanigan; Katalin Kalman; Yann Lefievre; Michael Pennington; K George Chandy; Raymond S Norton
Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.
Mark D Lanigan; Michael Pennington; Y Lefievre; H Rauer; Raymond S Norton
Designed peptide analogues of the potassium channel blocker ShK toxin.
Mark D Lanigan; J E Tudor; Michael Pennington; Raymond S Norton
A helical capping motif in ShK toxin and its role in helix stabilization.

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All Publications

2002: Mark D Lanigan; Katalin Kalman; Yann Lefievre; Michael Pennington; K George Chandy; Raymond S Norton
Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.
Biochemistry 2002;41(40):11963-71.
2001: Mark D Lanigan; Michael Pennington; Y Lefievre; H Rauer; Raymond S Norton
Designed peptide analogues of the potassium channel blocker ShK toxin.
Biochemistry 2001;40(51):15528-37.
2001: Mark D Lanigan; J E Tudor; Michael Pennington; Raymond S Norton
A helical capping motif in ShK toxin and its role in helix stabilization.
Biopolymers 2001;58(4):422-36.
2000: H Rauer; Mark D Lanigan; Michael Pennington; J Aiyar; S Ghanshani; Michael D Cahalan; Raymond S Norton; K George Chandy
Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.
The Journal of biological chemistry 2000;275(2):1201-8.
1999: Michael Pennington; Mark D Lanigan; Katalin Kalman; Vladimir M Mahnir; H Rauer; C T McVaugh; D Behm; D Donaldson; K George Chandy; William R Kem; Raymond S Norton
Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.
Biochemistry 1999;38(44):14549-58.
1998: Katalin Kalman; Michael Pennington; Mark D Lanigan; A Nguyen; H Rauer; Vladimir M Mahnir; K Paschetto; William R Kem; Stephan Grissmer; George A Gutman; E P Christian; Michael D Cahalan; Raymond S Norton; K George Chandy
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.
The Journal of biological chemistry 1998;273(49):32697-707.

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