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Lars Lannfelt
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45
Basun, Hans
32
Winblad, Bengt
24
Wahlund, Lars-Olof
22
Axelman, Karin
20
Viitanen, Matti
17
Cowburn, Richard
16
Lilius, Lena
14
Kilander, Lena
14
Ingelsson, Martin
13
Nilsson, Lars
11
Forsell, Charlotte
10
Glaser, Anna
9
Almkvist, Ove
8
Corder, Elizabeth
8
Giedraitis, Vilmantas
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All Publications
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2009: Lord Anna; Gumucio Astrid; Englund Hillevi; Sehlin Dag; Sundquist Valentina Screpanti; Söderberg Linda; Möller Christer; Gellerfors Pär; Lannfelt Lars; Pettersson Frida Ekholm; Nilsson Lars N G
An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease.
Neurobiology of disease 2009;36(3):425-34.
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2009: Philipson Ola; Lannfelt Lars; Nilsson Lars N G
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
FEBS letters 2009;583(18):3021-6.
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2009: Philipson Ola; Hammarström Per; Nilsson K Peter R; Portelius Erik; Olofsson Tommie; Ingelsson Martin; Hyman Bradley T; Blennow Kaj; Lannfelt Lars; Kalimo Hannu; Nilsson Lars N G
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Neurobiology of aging 2009;30(9):1393-405.
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2009: Rönnemaa E; Zethelius B; Sundelöf J; Sundström J; Degerman-Gunnarsson M; Lannfelt L; Berne C; Kilander L
Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men.
Diabetologia 2009;52(8):1504-10.
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2009: Santillo Alexander Frizell; Skoglund Lena; Lindau Maria; Eeg-Olofsson Karin Edebol; Tovi Metin; Engler Henry; Brundin Rose-Marie; Ingvast Sofie; Lannfelt Lars; Glaser Anna; Kilander Lena
Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation.
Alzheimer disease and associated disorders 2009;23(3):298-300.
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2009: Marcello Andrea; Wirths Oliver; Schneider-Axmann Thomas; Degerman-Gunnarsson Malin; Lannfelt Lars; Bayer Thomas A
Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(7):913-20.
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2009: Ingelsson Martin; Basun Hans; Pettersson Frida Ekholm; Kilander Lena; Nilsson Lars N G; Lannfelt Lars
[Rare mutations aim toward future treatment]
Läkartidningen 2009;106(20):1396-400.
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2009: Lord Anna; Englund Hillevi; Söderberg Linda; Tucker Stina; Clausen Fredrik; Hillered Lars; Gordon Marcia; Morgan Dave; Lannfelt Lars; Pettersson Frida E; Nilsson Lars N G
Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice.
The FEBS journal 2009;276(4):995-1006.
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2009: Skoglund Lena; Brundin RoseMarie; Olofsson Tommie; Kalimo Hannu; Ingvast Sofie; Blom Elin S; Giedraitis Vilmantas; Ingelsson Martin; Lannfelt Lars; Basun Hans; Glaser Anna
Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation.
Neurogenetics 2009;10(1):27-34.
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2009: Näsström Tomas; Wahlberg Therese; Karlsson Mikael; Nikolajeff Fredrik; Lannfelt Lars; Ingelsson Martin; Bergström Joakim
The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers.
Biochemical and biophysical research communications 2009;378(4):872-6.
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2009: Sundelöf Johan; Kilander Lena; Helmersson Johanna; Larsson Anders; Rönnemaa Elina; Degerman-Gunnarsson Malin; Sjögren Per; Basun Hans; Lannfelt Lars; Basu Samar
Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study.
Journal of Alzheimer's disease : JAD 2009;18(1):71-8.
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2009: Sundelöf Johan; Kilander Lena; Helmersson Johanna; Larsson Anders; Rönnemaa Elina; Degerman-Gunnarsson Malin; Basun Hans; Lannfelt Lars; Basu Samar
Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study.
Journal of Alzheimer's disease : JAD 2009;18(1):79-87.
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2009: Englund Hillevi; Degerman Gunnarsson Malin; Brundin Rose Marie; Hedlund Marie; Kilander Lena; Lannfelt Lars; Pettersson Frida Ekholm
Oligomerization partially explains the lowering of Abeta42 in Alzheimer's disease cerebrospinal fluid.
Neuro-degenerative diseases 2009;6(4):139-47.
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2009: Blom Elin S; Giedraitis Vilmantas; Zetterberg Henrik; Fukumoto Hiroaki; Blennow Kaj; Hyman Bradley T; Irizarry Michael C; Wahlund Lars-Olof; Lannfelt Lars; Ingelsson Martin
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
Dementia and geriatric cognitive disorders 2009;27(5):458-64.
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2009: Giedraitis Vilmantas; Kilander Lena; Degerman-Gunnarsson Malin; Sundelöf Johan; Axelsson Tomas; Syvänen Ann-Christine; Lannfelt Lars; Glaser Anna
Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men.
Dementia and geriatric cognitive disorders 2009;27(1):59-68.
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2008: O'Callaghan Paul; Sandwall Elina; Li Jin-Ping; Yu Hong; Ravid Rivka; Guan Zhi-Zhong; van Kuppevelt Toin H; Nilsson Lars N G; Ingelsson Martin; Hyman Bradley T; Kalimo Hannu; Lindahl Ulf; Lannfelt Lars; Zhang Xiao
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
Brain pathology (Zurich, Switzerland) 2008;18(4):548-61.
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2008: Sundelöf J; Arnlöv J; Ingelsson E; Sundström J; Basu S; Zethelius B; Larsson A; Irizarry M C; Giedraitis V; Rönnemaa E; Degerman-Gunnarsson M; Hyman B T; Basun H; Kilander L; Lannfelt L
Serum cystatin C and the risk of Alzheimer disease in elderly men.
Neurology 2008;71(14):1072-9.
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2008: Lannfelt Lars; Blennow Kaj; Zetterberg Henrik; Batsman Stellan; Ames David; Harrison John; Masters Colin L; Targum Steve; Bush Ashley I; Murdoch Ross; Wilson Janet; Ritchie Craig W;
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.
Lancet neurology 2008;7(9):779-86.
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2008: Rönnemaa E; Zethelius B; Sundelöf J; Sundström J; Degerman-Gunnarsson M; Berne C; Lannfelt L; Kilander L
Impaired insulin secretion increases the risk of Alzheimer disease.
Neurology 2008;71(14):1065-71.
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2008: Blom Elin S; Holmans Peter; Arepalli Sampath; Adighibe Omanma; Hamshere Marian L; Gatz Margaret; Pedersen Nancy L; Bergem A L Mina; Owen Michael J; Hollingworth Paul; Goate Alison; Williams Julie; Lannfelt Lars; Hardy John; Wavrant-De Vrièze Fabienne; Glaser Anna
Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(6):778-83.
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2008: Basun Hans; Bogdanovic Nenad; Ingelsson Martin; Almkvist Ove; Näslund Jan; Axelman Karin; Bird Thomas D; Nochlin David; Schellenberg Gerard D; Wahlund Lars-Olof; Lannfelt Lars
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
Archives of neurology 2008;65(4):499-505.
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2008: Sundelöf Johan; Giedraitis Vilmantas; Irizarry Michael C; Sundström Johan; Ingelsson Erik; Rönnemaa Elina; Arnlöv Johan; Gunnarsson Malin Degerman; Hyman Bradley T; Basun Hans; Ingelsson Martin; Lannfelt Lars; Kilander Lena
Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study.
Archives of neurology 2008;65(2):256-63.
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2008: Skoglund L; Viitanen M; Kalimo H; Lannfelt L; Jönhagen M E; Ingelsson M; Glaser A; Herva R
The tau S305S mutation causes frontotemporal dementia with parkinsonism.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2008;15(2):156-61.
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2008: Blom Elin S; Viswanathan Jayashree; Kilander Lena; Helisalmi Seppo; Soininen Hilkka; Lannfelt Lars; Ingelsson Martin; Glaser Anna; Hiltunen Mikko
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease.
European journal of human genetics : EJHG 2008;16(2):171-5.
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2008: Engler Henry; Santillo Alexander Frizell; Wang Shu Xia; Lindau Maria; Savitcheva Irina; Nordberg Agneta; Lannfelt Lars; Långström Bengt; Kilander Lena
In vivo amyloid imaging with PET in frontotemporal dementia.
European journal of nuclear medicine and molecular imaging 2008;35(1):100-6.
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2007: Giedraitis Vilmantas; Sundelöf Johan; Irizarry Michael C; Gårevik Nina; Hyman Bradley T; Wahlund Lars-Olof; Ingelsson Martin; Lannfelt Lars
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease.
Neuroscience letters 2007;427(3):127-31.
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2007: Englund Hillevi; Sehlin Dag; Johansson Ann-Sofi; Nilsson Lars N G; Gellerfors Pär; Paulie Staffan; Lannfelt Lars; Pettersson Frida Ekholm
Sensitive ELISA detection of amyloid-beta protofibrils in biological samples.
Journal of neurochemistry 2007;103(1):334-45.
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2007: Sahlin Charlotte; Pettersson Frida Ekholm; Nilsson Lars N G; Lannfelt Lars; Johansson Ann-Sofi
Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease.
The European journal of neuroscience 2007;26(4):882-9.
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2007: Nilsson K Peter R; Aslund Andreas; Berg Ina; Nyström Sofie; Konradsson Peter; Herland Anna; Inganäs Olle; Stabo-Eeg Frantz; Lindgren Mikael; Westermark Gunilla T; Lannfelt Lars; Nilsson Lars N G; Hammarström Per
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes.
ACS chemical biology 2007;2(8):553-60.
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2007: Wollmer M Axel; Sleegers Kristel; Ingelsson Martin; Zekanowski Cezary; Brouwers Nathalie; Maruszak Aleksandra; Brunner Fabienne; Huynh Kim-Dung; Kilander Lena; Brundin Rose-Marie; Hedlund Marie; Giedraitis Vilmantas; Glaser Anna; Engelborghs Sebastiaan; De Deyn Peter P; Kapaki Elisabeth; Tsolaki Magdalini; Daniilidou Makrina; Molyva Dimitra; Paraskevas George P; Thal Dietmar R; Barcikowska Maria; Kuznicki Jacek; Lannfelt Lars; Van Broeckhoven Christine; Nitsch Roger M; Hock Christoph; Papassotiropoulos Andreas
Association study of cholesterol-related genes in Alzheimer's disease.
Neurogenetics 2007;8(3):179-88.
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2007: Warensjö Eva; Ingelsson Erik; Lundmark Per; Lannfelt Lars; Syvänen Ann-Christine; Vessby Bengt; Risérus Ulf
Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity.
Obesity (Silver Spring, Md.) 2007;15(7):1732-40.
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2007: Blennow Kaj; Zetterberg Henrik; Minthon Lennart; Lannfelt Lars; Strid Stig; Annas Peter; Basun Hans; Andreasen Niels
Longitudinal stability of CSF biomarkers in Alzheimer's disease.
Neuroscience letters 2007;419(1):18-22.
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2007: Sahlin Charlotte; Lord Anna; Magnusson Kristina; Englund Hillevi; Almeida Claudia G; Greengard Paul; Nyberg Fred; Gouras Gunnar K; Lannfelt Lars; Nilsson Lars N G
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
Journal of neurochemistry 2007;101(3):854-62.
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2007: Wohlin M; Sundström J; Lannfelt Lars; Axelsson Tomas; Syvänen A C; Andrén B; Basu S; Lind L
Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive pattern.
Lipids 2007;42(5):451-6.
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2007: Johansson Ann-Sofi; Bergquist Jonas; Volbracht Christiane; Päiviö Anna; Leist Marcel; Lannfelt Lars; Westlind-Danielsson Anita
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation.
Neuroreport 2007;18(6):559-63.
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2007: Nilsson Lars N G; Lannfelt Lars; Basun Hans; Nordberg Agneta; Winblad Bengt
[Don't underestimate the value of transgenic animal models of Alzheimer disease]
Läkartidningen 2007;104(10):798-9; discussion 799-800.
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2007: Johansson Ann-Sofi; Garlind Anita; Berglind-Dehlin Fredrik; Karlsson Göran; Edwards Katarina; Gellerfors Pär; Ekholm-Pettersson Frida; Palmblad Jan; Lannfelt Lars
Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro.
The FEBS journal 2007;274(4):990-1000.
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2007: Englund Hillevi; Annerén Göran; Gustafsson Jan; Wester Ulrika; Wiltfang Jens; Lannfelt Lars; Blennow Kaj; Höglund Kina
Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome.
Dementia and geriatric cognitive disorders 2007;24(5):369-74.
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2007: Degerman Gunnarsson M; Kilander L; Basun H; Lannfelt L
Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease.
Dementia and geriatric cognitive disorders 2007;24(4):247-52.
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2006: Giedraitis V; Hedlund M; Skoglund L; Blom E; Ingvast S; Brundin R; Lannfelt L; Glaser A
New Alzheimer's disease locus on chromosome 8.
Journal of medical genetics 2006;43(12):931-5.
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2006: Ingelsson Martin; Ramasamy Karunya; Cantuti-Castelvetri Ippolita; Skoglund Lena; Matsui Toshifumi; Orne Jennifer; Kowa Hasimoto; Raju Susan; Vanderburg Charles R; Augustinack Jean C; de Silva Rohan; Lees Andrew J; Lannfelt Lars; Growdon John H; Frosch Matthew P; Standaert David G; Irizarry Michael C; Hyman Bradley T
No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.
Acta neuropathologica 2006;112(4):439-49.
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2006: Johansson Ann-Sofi; Berglind-Dehlin Fredrik; Karlsson Göran; Edwards Katarina; Gellerfors Pär; Lannfelt Lars
Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt.
The FEBS journal 2006;273(12):2618-30.
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2006: Murphy Eric J; Huang Hsueh-Meei; Cowburn Richard F; Lannfelt Lars; Gibson Gary E
Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.
Brain research bulletin 2006;69(1):79-85.
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2006: Lord Anna; Kalimo Hannu; Eckman Chris; Zhang Xiao-Qun; Lannfelt Lars; Nilsson Lars N G
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.
Neurobiology of aging 2006;27(1):67-77.
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2005: Selle Hartmut; Lamerz Jens; Buerger Katharina; Dessauer Andreas; Hager Klaus; Hampel Harald; Karl Johann; Kellmann Markus; Lannfelt Lars; Louhija Jukka; Riepe Matthias; Rollinger Wolfgang; Tumani Hayrettin; Schrader Michael; Zucht Hans-Dieter
Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease.
Combinatorial chemistry & high throughput screening 2005;8(8):801-6.
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2005: Ingelsson Martin; Nilsson Lars; Basun Hans; Aquilonius Sten-Magnus; Lannfelt Lars
[Conformationally altered proteins cause neurodegenerative diseases]
Läkartidningen 2005;102(47):3542-3, 3545-6, 3549 passim.
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2005: Stenh Charlotte; Englund Hillevi; Lord Anna; Johansson Ann-Sofi; Almeida Claudia G; Gellerfors Pär; Greengard Paul; Gouras Gunnar K; Lannfelt Lars; Nilsson Lars N G
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.
Annals of neurology 2005;58(1):147-50.
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2005: Flood Fiona; Murphy Suzanne; Cowburn Richard F; Lannfelt Lars; Walker Brian; Johnston Janet A
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
The Biochemical journal 2005;385(Pt 2):545-50.
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2004: Johnson Janel; Ostojic Jovanka; Lannfelt Lars; Glaser Anna; Basun Hans; Rogaeva Ekaterina; Kawarai Toshitaka; Bruni Amalia; St George Hyslop Peter H; Goate Alison; Pastor Pau; Chakraverty Sumi; Norton Joanne; Morris John C; Hardy John; Singleton Andrew
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.
Neuroscience letters 2004;363(2):99-101.
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2004: Päiviö A; Jarvet J; Gräslund A; Lannfelt L; Westlind-Danielsson A
Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.
Journal of molecular biology 2004;339(1):145-59.
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2004: Bergman Anna; Hansson Emil M; Pursglove Sharon E; Farmery Mark R; Lannfelt Lars; Lendahl Urban; Lundkvist Johan; Näslund Jan
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.
The Journal of biological chemistry 2004;279(16):16744-53.
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2004: Froelich-Fabre Susanne; Skoglund Lena; Ostojic Jovanka; Kilander Lena; Lindau Maria; Glaser Anna; Basun Hans; Lannfelt Lars
Clinical and molecular aspects of frontotemporal dementia.
Neuro-degenerative diseases 2004;1(4-5):218-24.
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2004: Ostojic Jovanka; Elfgren Christina; Passant Ulla; Nilsson Karin; Gustafson Lars; Lannfelt Lars; Froelich Fabre Susanne
The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.
Dementia and geriatric cognitive disorders 2004;17(4):298-301.
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2004: Passant Ulla; Ostojic Jovanka; Froelich Fabre Susanne; Gustafson Lars; Lannfelt Lars; Larsson Elna-Marie; Nilsson Karin; Rosén Ingmar; Elfgren Christina
Familial presenile dementia with bitemporal atrophy.
Dementia and geriatric cognitive disorders 2004;17(4):287-92.
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2003: Olsson Annika; Höglund Kina; Sjögren Magnus; Andreasen Niels; Minthon Lennart; Lannfelt Lars; Buerger Katharina; Möller Hans Jürgen; Hampel Harald; Davidsson Pia; Blennow Kaj
Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients.
Experimental neurology 2003;183(1):74-80.
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2003: Froelich Fabre Susanne; Axelman Pia; Almkvist Asa; Basun Hans; Lannfelt Lars
Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;121B(1):112-8.
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2003: Bergman Anna; Religa Dorota; Karlström Helena; Laudon Hanna; Winblad Bengt; Lannfelt Lars; Lundkvist Johan; Näslund Jan
APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
Experimental cell research 2003;287(1):1-9.
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2003: Ostojic Jovanka; Axelman Karin; Lannfelt Lars; Froelich-Fabre Susanne
No evidence of linkage to chromosome 9q21-22 in a Swedish family with frontotemporal dementia and amyotrophic lateral sclerosis.
Neuroscience letters 2003;340(3):245-7.
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2003: Axelman Karin; Lannfelt Lars; Almkvist Ove; Carlsson Marianne
Life situation, coping and quality of life in people with high and low risk of developing Alzheimer's disease.
Dementia and geriatric cognitive disorders 2003;16(4):220-8.
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2003: Almkvist Ove; Axelman Karin; Basun Hans; Jensen Malene; Viitanen Matti; Wahlund Lars-Olof; Lannfelt Lars
Clinical findings in nondemented mutation carriers predisposed to Alzheimer's disease: a model of mild cognitive impairment.
Acta neurologica Scandinavica. Supplementum 2003;179():77-82.
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2002: Stenh Charlotte; Nilsberth Camilla; Hammarbäck Josefin; Engvall Benita; Näslund Jan; Lannfelt Lars
The Arctic mutation interferes with processing of the amyloid precursor protein.
Neuroreport 2002;13(15):1857-60.
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2002: Sennvik Kristina; Nilsberth Camilla; Stenh Charlotte; Lannfelt Lars; Benedikz Eirikur
The Arctic Alzheimer mutation enhances sensitivity to toxic stress in human neuroblastoma cells.
Neuroscience letters 2002;326(1):51-5.
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2002: Almkvist O; Axelman K; Basun H; Wahlund L O; Lannfelt L
Conversion from preclinical to dinical stage of Alzheimer's disease as shown by decline of cognitive function in carriers of the Swedish APP-mutation.
Journal of neural transmission. Supplementum 2002;(62):117-25.
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2002: Basun Hans; Nilsberth Camilla; Eckman Christopher; Lannfelt Lars; Younkin Steven
Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine.
Dementia and geriatric cognitive disorders 2002;14(3):156-60.
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2001: Bogdanovic N; Bretillon L; Lund E G; Diczfalusy U; Lannfelt L; Winblad B; Russell D W; Björkhem I
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.
Neuroscience letters 2001;314(1-2):45-8.
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2001: Nilsberth C; Westlind-Danielsson A; Eckman C B; Condron M M; Axelman K; Forsell C; Stenh C; Luthman J; Teplow D B; Younkin S G; Näslund J; Lannfelt L
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
Nature neuroscience 2001;4(9):887-93.
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2001: Ingelson M; Fabre S F; Lilius L; Andersen C; Viitanen M; Almkvist O; Wahlund L O; Lannfelt L
Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4.
Neuroreport 2001;12(5):905-9.
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2001: Fabre S F; Forsell C; Viitanen M; Sjögren M; Wallin A; Blennow K; Blomberg M; Andersen C; Wahlund L O; Lannfelt L
Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations.
Experimental neurology 2001;168(2):413-8.
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2001: Blomberg M; Jensen M; Basun H; Lannfelt L; Wahlund L O
Cerebrospinal fluid tau levels increase with age in healthy individuals.
Dementia and geriatric cognitive disorders 2001;12(2):127-32.
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2000: Andersen C; Froelich Fabre S; Ostberg P; Lannfelt L; Wahlund L
Tau protein in cerebrospinal fluid from semantic dementia patients.
Neuroscience letters 2000;294(3):155-8.
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2000: Corder E H; Basun H; Fratiglioni L; Guo Z; Lannfelt L; Viitanen M; Corder L S; Manton K G; Winblad B
Inherited frailty. ApoE alleles determine survival after a diagnosis of heart disease or stroke at ages 85+.
Annals of the New York Academy of Sciences 2000;908():295-8.
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2000: Jensen M; Hartmann T; Engvall B; Wang R; Uljon S N; Sennvik K; Näslund J; Muehlhauser F; Nordstedt C; Beyreuther K; Lannfelt L
Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems.
Molecular medicine (Cambridge, Mass.) 2000;6(4):291-302.
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2000: Mattila K M; Axelman K; Rinne J O; Blomberg M; Lehtimäki T; Laippala P; Röyttä M; Viitanen M; Wahlund L; Winblad B; Lannfelt L
Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women.
Neuroscience letters 2000;282(1-2):45-8.
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1999: Lilius L; Froelich Fabre S; Basun H; Forsell C; Axelman K; Mattila K; Andreadis A; Viitanen M; Winblad B; Fratiglioni L; Lannfelt L
Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer's disease.
Neuroscience letters 1999;277(1):29-32.
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1999: Wahlund L O; Basun H; Almkvist O; Julin P; Axelman K; Shigeta M; Jelic V; Nordberg A; Lannfelt L
A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation.
Dementia and geriatric cognitive disorders 1999;10(6):526-33.
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1999: Mustafa A; Lannfelt L; Lilius L; Islam A; Winblad B; Adem A
Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation.
Dementia and geriatric cognitive disorders 1999;10(6):446-51.
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1999: Ingelson M; Blomberg M; Benedikz E; Wahlund L O; Karlsson E; Vanmechelen E; Lannfelt L
Tau immunoreactivity detected in human plasma, but no obvious increase in dementia.
Dementia and geriatric cognitive disorders 1999;10(6):442-5.
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1999: Savioz A; Leuba G; Forsell C; Lilius L; Rossier C; Saini K; Bouras C; Lannfelt L
No detected mutations in the genes for the amyloid precursor protein and presenilins 1 and 2 in a swiss early-onset Alzheimer's disease family with a dominant mode of inheritance.
Dementia and geriatric cognitive disorders 1999;10(6):431-6.
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1999: Froelich S; Houlden H; Rizzu P; Chakraverty S; Baker M; Kwon J; Nowotny P; Isaacs A; Nowotny V; Wauters E; van Baren M J; Oostra B A; Hardy J; Lannfelt L; Goate A; Hutton M; Lendon C L; Heutink P
Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
Genomics 1999;60(2):129-36.
-
1999: Nilsberth C; Luthman J; Lannfelt L; Schultzberg M
Expression of presenilin 1 mRNA in rat peripheral organs and brain.
The Histochemical journal 1999;31(8):515-23.
-
1999: Wahlund L O; Julin P; Lannfelt L; Lindqvist J; Svensson L
Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients.
Dementia and geriatric cognitive disorders 1999;10(4):262-8.
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1999: Sheu K F; Brown A M; Kristal B S; Kalaria R N; Lilius L; Lannfelt L; Blass J P
A DLST genotype associated with reduced risk for Alzheimer's disease.
Neurology 1999;52(7):1505-7.
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1999: Jensen M; Schröder J; Blomberg M; Engvall B; Pantel J; Ida N; Basun H; Wahlund L O; Werle E; Jauss M; Beyreuther K; Lannfelt L; Hartmann T
Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression.
Annals of neurology 1999;45(4):504-11.
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1999: Vestling M; Cedazo-Mínguez A; Adem A; Wiehager B; Racchi M; Lannfelt L; Cowburn R F
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.
Biochimica et biophysica acta 1999;1453(3):341-50.
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1999: Marutle A; Warpman U; Bogdanovic N; Lannfelt L; Nordberg A
Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation.
Journal of neurochemistry 1999;72(3):1161-9.
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1999: Bronge L; Fernaeus S E; Blomberg M; Ingelson M; Lannfelt L; Isberg B; Wahlund L O
White matter lesions in Alzheimer patients are influenced by apolipoprotein E genotype.
Dementia and geriatric cognitive disorders 1999;10(2):89-96.
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1999: Sheu K F; Brown A M; Haroutunian V; Kristal B S; Thaler H; Lesser M; Kalaria R N; Relkin N R; Mohs R C; Lilius L; Lannfelt L; Blass J P
Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.
Annals of neurology 1999;45(1):48-53.
-
1999: Axelman K; Basun H; Lannfelt L
Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease.
Dementia and geriatric cognitive disorders 1999;10(1):1-5.
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1998: Mattila K M; Forsell C; Pirttilä T; Rinne J O; Lehtimäki T; Röyttä M; Lilius L; Eerola A; St George-Hyslop P H; Frey H; Lannfelt L
The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.
Annals of neurology 1998;44(6):965-7.
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1998: Gibson G E; Zhang H; Sheu K F; Bogdanovich N; Lindsay J G; Lannfelt L; Vestling M; Cowburn R F
Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation.
Annals of neurology 1998;44(4):676-81.
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1998: Yamada H; Dahl M L; Viitanen M; Winblad B; Sjöqvist F; Lannfelt L
No association between familial Alzheimer disease and cytochrome P450 polymorphisms.
Alzheimer disease and associated disorders 1998;12(3):204-7.
-
1998: Yamada H; Dahl M L; Lannfelt L; Viitanen M; Winblad B; Sjöqvist F
CYP2D6 and CYP2C19 genotypes in an elderly Swedish population.
European journal of clinical pharmacology 1998;54(6):479-81.
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1998: Axelman K; Basun H; Lannfelt L
Wide range of disease onset in a family with Alzheimer disease and a His163Tyr mutation in the presenilin-1 gene.
Archives of neurology 1998;55(5):698-702.
-
1998: Lannfelt L
Biochemical diagnostic markers to detect early Alzheimer's disease.
Neurobiology of aging 1998;19(2):165-7.
-
1998: Julin P; Almkvist O; Basun H; Lannfelt L; Svensson L; Winblad B; Wahlund L O
Brain volumes and regional cerebral blood flow in carriers of the Swedish Alzheimer amyloid protein mutation.
Alzheimer disease and associated disorders 1998;12(1):49-53.
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1998: Jelic V; Blomberg M; Dierks T; Basun H; Shigeta M; Julin P; Jensen M; Lannfelt L; Winblad B; Wahlund L O
EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline.
Neuroreport 1998;9(1):157-60.
-
1998: Almkvist O; Basun H; Bäckman L; Herlitz A; Lannfelt L; Small B; Viitanen M; Wahlund L O; Winblad B
Mild cognitive impairment--an early stage of Alzheimer's disease?
Journal of neural transmission. Supplementum 1998;54():21-9.
-
1997: Johnston J A; Lannfelt L; Wiehager B; O'Neill C; Cowburn R F
Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations.
Biochimica et biophysica acta 1997;1362(2-3):183-92.
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1997: Gibson G E; Vestling M; Zhang H; Szolosi S; Alkon D; Lannfelt L; Gandy S; Cowburn R F
Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.
Neurobiology of aging 1997;18(6):573-80.
-
1997: Lannfelt L
The genetics and pathophysiology of Alzheimer's disease.
Journal of internal medicine 1997;242(4):281-4.
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1997: Forsell C; Froelich S; Axelman K; Vestling M; Cowburn R F; Lilius L; Johnston J A; Engvall B; Johansson K; Dahlkild A; Ingelson M; St George-Hyslop P H; Lannfelt L
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease.
Neuroscience letters 1997;234(1):3-6.
-
1997: Svensson A L; Warpman U; Hellström-Lindahl E; Bogdanovic N; Lannfelt L; Nordberg A
Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes.
Neuroscience letters 1997;232(1):37-40.
-
1997: Shanahan C; Gibson G E; Cowburn R F; Johnston J A; Wiehager B; Lannfelt L; O'Neill C
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation.
Neuroscience letters 1997;232(1):33-6.
-
1997: Froelich S; Basun H; Forsell C; Lilius L; Axelman K; Andreadis A; Lannfelt L
Mapping of a disease locus for familial rapidly progressive frontotemporal dementia to chromosome 17q12-21.
American journal of medical genetics 1997;74(4):380-5.
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1997: Jelic V; Julin P; Shigeta M; Nordberg A; Lannfelt L; Winblad B; Wahlund L O
Apolipoprotein E epsilon4 allele decreases functional connectivity in Alzheimer's disease as measured by EEG coherence.
Journal of neurology, neurosurgery, and psychiatry 1997;63(1):59-65.
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1997: Lindh M; Blomberg M; Jensen M; Basun H; Lannfelt L; Engvall B; Scharnagel H; März W; Wahlund L O; Cowburn R F
Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein.
Neuroscience letters 1997;229(2):85-8.
-
1997: Vestling M; Adem A; Racchi M; Gibson G E; Lannfelt L; Cowburn R F
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.
Neuroreport 1997;8(8):2031-5.
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1997: Basun H; Almkvist O; Axelman K; Brun A; Campbell T A; Collinge J; Forsell C; Froelich S; Wahlund L O; Wetterberg L; Lannfelt L
Clinical characteristics of a chromosome 17-linked rapidly progressive familial frontotemporal dementia.
Archives of neurology 1997;54(5):539-44.
-
1997: Corder E H; Jelic V; Basun H; Lannfelt L; Valind S; Winblad B; Nordberg A
No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes.
Archives of neurology 1997;54(3):273-7.
-
1996: Johnston J A; Norgren S; Ravid R; Wasco W; Winblad B; Lannfelt L; Cowburn R F
Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains.
Brain research. Molecular brain research 1996;43(1-2):85-95.
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1996: Johnston J A; Norgren S; Annerén G; Cowburn R F; Lannfelt L
A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA.
Brain research. Molecular brain research 1996;43(1-2):77-84.
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1996: Basun H; Lannfelt L
[Alzheimer disease and related conditions. Increased knowledge. New preparations are on the way]
Läkartidningen 1996;93(50):4617-9.
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1996: Ingelson M; Vanmechelen E; Lannfelt L
Microtubule-associated protein tau in human fibroblasts with the Swedish Alzheimer mutation.
Neuroscience letters 1996;220(1):9-12.
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1996: Corder E H; Lannfelt L; Basun H
Apolipoprotein E genotype and the rate of decline in probable Alzheimer disease.
Archives of neurology 1996;53(11):1094-5.
-
1996: Johnston J A; Froelich S; Lannfelt L; Cowburn R F
Quantification of presenilin-1 mRNA in Alzheimer's disease brains.
FEBS letters 1996;394(3):279-84.
-
1996: Blomberg M; Jensen M; Basun H; Lannfelt L; Wahlund L O
Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up.
Neuroscience letters 1996;214(2-3):163-6.
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1996: Basun H; Corder E H; Guo Z; Lannfelt L; Corder L S; Manton K G; Winblad B; Viitanen M
Apolipoprotein E polymorphism and stroke in a population sample aged 75 years or more.
Stroke; a journal of cerebral circulation 1996;27(8):1310-5.
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1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
-
1996: Sherrington R; Froelich S; Sorbi S; Campion D; Chi H; Rogaeva E A; Levesque G; Rogaev E I; Lin C; Liang Y; Ikeda M; Mar L; Brice A; Agid Y; Percy M E; Clerget-Darpoux F; Piacentini S; Marcon G; Nacmias B; Amaducci L; Frebourg T; Lannfelt L; Rommens J M; St George-Hyslop P H
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.
Human molecular genetics 1996;5(7):985-8.
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1996: Lannfelt L; Jensen M; Froelich S; Basun H; Näslund J; Nordstadt C
[A model system in cell culture shows pathogenic processes. Biochemical diagnosis in Alzheimer dementia]
Läkartidningen 1996;93(24):2326-31.
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1996: Kalaria R N; Cohen D L; Greenberg B D; Savage M J; Bogdanovic N E; Winblad B; Lannfelt L; Adem A
Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome.
Neuroreport 1996;7(8):1377-81.
-
1996: Liu L; Forsell C; Lilius L; Axelman K; Corder E H; Lannfelt L
Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families.
American journal of medical genetics 1996;67(3):306-11.
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1996: Corder E H; Lannfelt L; Viitanen M; Corder L S; Manton K G; Winblad B; Basun H
Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition.
Archives of neurology 1996;53(5):418-22.
-
1996: Corder E H; Basun H; Lannfelt L; Viitanen M; Winblad B
Attenuation of apolipoprotein E Epsilon4 allele gene dose in late age.
Lancet 1996;347(9000):542.
-
1996: Lannfelt L
Genetics of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;168():25-7.
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1995: Lannfelt L; Basun H; Vigo-Pelfrey C; Wahlund L O; Winblad B; Lieberburg I; Schenk D
Amyloid beta-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation.
Neuroscience letters 1995;199(3):203-6.
-
1995: Corder E; Basun H; Lannfelt L; Viitanen M; Winblad B
Apolipoprotein E-epsilon 4 gene dose.
Lancet 1995;346(8980):967-8.
-
1995: Lannfelt L; Basun H; Wahlund L O; Rowe B A; Wagner S L
Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease.
Nature medicine 1995;1(8):829-32.
-
1995: Lannfelt L; Lilius L; Viitanen M; Houlden H; Rossor M; Hardy J; Winblad B; Basun H
Microsatellite D21S210 (GT-12) allele frequencies in sporadic Alzheimer's disease.
Acta neurologica Scandinavica 1995;91(2):145-8.
-
1995: Jensen M; Basun H; Lannfelt L
Increased cerebrospinal fluid tau in patients with Alzheimer's disease.
Neuroscience letters 1995;186(2-3):189-91.
-
1995: Basun H; Grut M; Winblad B; Lannfelt L
Apolipoprotein epsilon 4 allele and disease progression in patients with late-onset Alzheimer's disease.
Neuroscience letters 1995;183(1-2):32-4.
-
1995: Forsell C; Lannfelt L
Amyloid precursor protein mutation at codon 713 (Ala-->Val) does not cause schizophrenia: non-pathogenic variant found at codon 705 (silent).
Neuroscience letters 1995;184(2):90-3.
-
1995: Vestling M; Cowburn R F; Venizelos N; Lannfelt L; Winblad B; Adem A
Characterization of muscarinic acetylcholine receptors in cultured adult skin fibroblasts: effects of the Swedish Alzheimer's disease APP 670/671 mutation on binding levels.
Journal of neural transmission. Parkinson's disease and dementia section 1995;10(1):1-10.
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1995: Lannfelt L; Pedersen N L; Lilius L; Axelman K; Johansson K; Viitanen M; Gatz M
Apolipoprotein epsilon 4 allele in Swedish twins and siblings with Alzheimer disease.
Alzheimer disease and associated disorders 1995;9(3):166-9.
-
1994: Axelman K; Basun H; Winblad B; Lannfelt L
A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation. A clinical and genealogical investigation.
Archives of neurology 1994;51(12):1193-7.
-
1994: Johnston J A; Cowburn R F; Norgren S; Wiehager B; Venizelos N; Winblad B; Vigo-Pelfrey C; Schenk D; Lannfelt L; O'Neill C
Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.
FEBS letters 1994;354(3):274-8.
-
1994: Lannfelt L; Lilius L; Nastase M; Viitanen M; Fratiglioni L; Eggertsen G; Berglund L; Angelin B; Linder J; Winblad B
Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease.
Neuroscience letters 1994;169(1-2):175-8.
-
1994: Lannfelt L; Johnston J; Bogdanovich N; Cowburn R
Amyloid precursor protein gene mutation at codon 670/671 in familial Alzheimer's disease in Sweden.
Biochemical Society transactions 1994;22(1):176-9.
-
1994: Lannfelt L; Bogdanovic N; Appelgren H; Axelman K; Lilius L; Hansson G; Schenk D; Hardy J; Winblad B
Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.
Neuroscience letters 1994;168(1-2):254-6.
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1993: Lannfelt L; Folkesson R; Mohammed A H; Winblad B; Hellgren D; Duff K; Hardy J
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research 1993;57(2):207-13.
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1993: Johnston J; Lilius L; Axelman K; Cowburn R; Johansson K; Viitanen M; Winblad B; Lannfelt L
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene fails to identify new mutations in Swedish Alzheimer's disease patients.
Human molecular genetics 1993;2(7):1045-6.
-
1993: Lannfelt L; Lilius L; Appelgren H; Axelman K; Forsell C; Liu L; Johansson K; Graff C
No linkage to chromosome 14 in Swedish Alzheimer's disease families.
Nature genetics 1993;4(3):218-9.
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1993: Lannfelt L; Viitanen M; Johansson K; Axelman K; Lilius L; Almqvist E; Winblad B
Low frequency of the APP 670/671 mutation in familial Alzheimer's disease in Sweden.
Neuroscience letters 1993;153(1):85-7.
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1992: Mullan M; Crawford F; Axelman K; Houlden H; Lilius L; Winblad B; Lannfelt L
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
Nature genetics 1992;1(5):345-7.
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