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Eric Lansdon

Research Profile

Chemicals & Drugs

Procedures

X Ray Crystallography

Living Beings

HIV-1

Concepts & Ideas

Phenomena

Protein Binding

Physiology

Mutation

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Publications

TOP 3
Jay Parrish; Leah Tong; Michael Wang; Carina Cannizzaro; Xiaowu Chen; Manoj C Desai; Eric B Lansdon; Xubin Zheng; Lianhong Xu
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Manuel Tsiang; Yili Xu; Dharmaraj Samuel; Kerim Babaoglu; Romas Geleziunas; Hongyan Guo; Wayne Huang; Magdeleine Hung; Gregg S Jones; Elaine Kan; Eric B Lansdon; Xiaohong Liu; Michael Mitchell; Anita Niedziela-Majka; Nikolai Novikov; Roman Sakowicz
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.

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All Publications

2013: Jay Parrish; Leah Tong; Michael Wang; Carina Cannizzaro; Xiaowu Chen; Manoj C Desai; Eric B Lansdon; Xubin Zheng; Lianhong Xu
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Bioorganic & medicinal chemistry letters 2013;23(5):1493-7.
2012: Manuel Tsiang; Yili Xu; Dharmaraj Samuel; Kerim Babaoglu; Romas Geleziunas; Hongyan Guo; Wayne Huang; Magdeleine Hung; Gregg S Jones; Elaine Kan; Eric B Lansdon; Xiaohong Liu; Michael Mitchell; Anita Niedziela-Majka; Nikolai Novikov; Roman Sakowicz
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
The Journal of biological chemistry 2012;287(25):21189-203.
2011: Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrobial agents and chemotherapy 2011;55(6):2905-15.
2011: Brian J Scarth; Kirsten L White; James M Chen; Eric B Lansdon; Swami Swaminathan; Michael D Miller; Matthias Götte
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.
Antimicrobial agents and chemotherapy 2011;55(6):2662-9.
2010: Eric B Lansdon; Katherine M Brendza; Magdeleine Hung; Ruth Wang; Susmith Mukund; Debi Jin; Gabriel Birkus; Nilima Kutty; Xiaohong Liu
Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
Journal of medicinal chemistry 2010;53(10):4295-9.
2010: Eric B Lansdon; Dharmaraj Samuel; Leanna Lagpacan; Katherine M Brendza; Kirsten L White; Magdeleine Hung; Xiaohong Liu; Constantine G Boojamra; Richard L Mackman; Tomas Cihlar; Adrian S Ray; Mary E McGrath; Swami Swaminathan
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.
Journal of molecular biology 2010;397(4):967-78.
2010: Michael L Mitchell; Jong Chan Son; Hongyan Guo; Yun-A Im; Eun Jung Cho; Jianhong Wang; Jaclyn Hayes; Michael Wang; Amber Paul; Eric B Lansdon; James M Chen; Doris Graupe; Gerry Rhodes; Gong-Xin He; Romas Geleziunas; Lianhong Xu; Choung U Kim
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2010;20(5):1589-92.
2010: Michael L Mitchell; Jong Chan Son; Ill Young Lee; Chong-Kyo Lee; Hae Soo Kim; Hongyan Guo; Jianhong Wang; Jaclyn Hayes; Michael Wang; Amber Paul; Eric B Lansdon; James M Chen; Gene Eisenberg; Romas Geleziunas; Lianhong Xu; Choung U Kim
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2010;20(5):1585-8.
2009: Thorsten A Kirschberg; Mini Balakrishnan; Neil H Squires; Tiffany Barnes; Katherine M Brendza; Xiaowu Chen; Eugene J Eisenberg; Weili Jin; Nilima Kutty; Stephanie Leavitt; Albert Liclican; Qi Liu; Xiaohong Liu; John Mak; Jason K Perry; Michael Wang; William J Watkins; Eric B Lansdon
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
Journal of medicinal chemistry 2009;52(19):5781-4.
2009: Joshua M Waters; Wesley O'Neal; Kirsten L White; Charles Wakeford; Eric B Lansdon; Jeanette Harris; Evguenia S Svarovskaia; Michael D Miller; Katyna Borroto-Esoda
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.
Antiviral therapy 2009;14(2):231-9.
2008: Thorsten A Kirschberg; Mini Balakrishnan; Wei Huang; Rebecca Hluhanich; Nilima Kutty; Albert C Liclican; Damian J McColl; Neil H Squires; Eric B Lansdon
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
Bioorganic & medicinal chemistry letters 2008;18(3):1131-4.
2007: Zhihao Yu; Eric B Lansdon; Irwin H Segel; Andrew J Fisher
Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.
Journal of molecular biology 2007;365(3):732-43.
2004: Eric B Lansdon; Andrew J Fisher; Irwin H Segel
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains.
Biochemistry 2004;43(14):4356-65.
2002: Eric B Lansdon; Irwin H Segel; Andrew J Fisher
Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum.
Biochemistry 2002;41(46):13672-80.