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Amélie Lansiaux

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Chemicals & Drugs

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Drug Screening Assays, Antitumor

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Tiphaine Rogez-Florent; Andrea Scozzafava; Perrine Six; Claudiu T Supuran; Christine Bal-Mahieu; Patrick Depreux; Catherine Foulon; Raphaël Frédérick; Sébastien Gluszok; Jean-François Goossens; Abigaëlle Gros; Amélie Lansiaux; Bernard Masereel; Samuel Meignan; Laurence Goossens
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.
Valérie Verones; Nicole Wattez; Marie Lecoeur; Amelie Lemoine; Christine Mahieu; Brigitte Baldeyrou; Pascal Berthelot; Amaury Farce; Nathalie Flouquet; Jean-François Goossens; Amélie Lansiaux; Nicolas Lebegue
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.
Cleopatra Neagoie; Sorin Rosca; Emeline Vedrenne; Brigitte Baldeyrou; Stéphane Bourg; Frédéric Buron; Amélie Lansiaux; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

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All Publications

2013: Tiphaine Rogez-Florent; Andrea Scozzafava; Perrine Six; Claudiu T Supuran; Christine Bal-Mahieu; Patrick Depreux; Catherine Foulon; Raphaël Frédérick; Sébastien Gluszok; Jean-François Goossens; Abigaëlle Gros; Amélie Lansiaux; Bernard Masereel; Samuel Meignan; Laurence Goossens
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.
Bioorganic & medicinal chemistry 2013;21(6):1451-64.
2013: Valérie Verones; Nicole Wattez; Marie Lecoeur; Amelie Lemoine; Christine Mahieu; Brigitte Baldeyrou; Pascal Berthelot; Amaury Farce; Nathalie Flouquet; Jean-François Goossens; Amélie Lansiaux; Nicolas Lebegue
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.
European journal of medicinal chemistry 2013;59():39-47.
2012: Cleopatra Neagoie; Sorin Rosca; Emeline Vedrenne; Brigitte Baldeyrou; Stéphane Bourg; Frédéric Buron; Amélie Lansiaux; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
European journal of medicinal chemistry 2012;49():379-96.
2012: Nicolas Matuszak; Giulio G Muccioli; Jacques H Poupaert; Brigitte Baldeyroux; Laurie Hamtiaux; Amélie Lansiaux; Didier M Lambert
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;45(3):263-71.
2011: Pierre Leblond; Samuel Meignan; Ullrich Bethe; Florence Le Tinier; Amélie Lansiaux
[The inhibitor of integrins Cilengitide: a new active drug in neuro-oncology].
Bulletin du cancer 2011;98(9):1083-90.
2011: Gang Ahn; Nadège Schifano-Faux; Jean-François Goossens; Brigitte Baldeyrou; Axel Couture; Pierre Grandclaudon; Amélie Lansiaux; Adina Ryckebusch
Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.
Bioorganic & medicinal chemistry letters 2011;21(8):2259-63.
2011: Magali Rebucci; Paul Peixoto; Amélie Dewitte; Nicole Wattez; Marie-Adeline De Nuncques; Nicolas Rezvoy; Claire Vautravers-Dewas; Marie-Pierre Buisine; Eric Guerin; Jean-Philippe Peyrat; Eric Lartigau; Amélie Lansiaux
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance.
International journal of oncology 2011;38(1):189-200.
2010: Nicolas Penel; Pierre Leblond; Amélie Lansiaux; Stéphanie Clisant; Eric Dansin; Antoine Adenis; Jacques Bonneterre
Justification of the starting dose as the main determinant of accrual time in dose-seeking oncology phase 1 trials.
Investigational new drugs 2010;28(6):839-43.
2010: Antonio Garofalo; Laurence Goossens; Brigitte Baldeyrou; Amélie Lemoine; Séverine Ravez; Perrine Six; Marie-Hélène David-Cordonnier; Jean-Paul Bonte; Patrick Depreux; Amélie Lansiaux; Jean-François Goossens
Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.
Journal of medicinal chemistry 2010;53(22):8089-103.
2010: Gang Ahn; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Brigitte Baldeyrou; Nadège Schifano-Faux; Pierre Grandclaudon; Axel Couture; Adina Ryckebusch
Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties.
Bioorganic & medicinal chemistry 2010;18(22):8119-33.
2010: Youssef Hajbi; Cléopatra Neagoie; Bérenger Biannic; Aurélie Chilloux; Emeline Vedrenne; Brigitte Baldeyrou; Christian Bailly; Jean-Yves Mérour; Sorin Rosca; Sylvain Routier; Amélie Lansiaux
Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.
European journal of medicinal chemistry 2010;45(11):5428-37.
2010: Marie Laronze-Cochard; Fabien Cochard; Etienne Daras; Amélie Lansiaux; Bertrand BRASSART; Enguerran Vanquelef; Elise Prost; Jean-Marc Nuzillard; Brigitte Baldeyrou; Jean-François Goosens; Olivier Lozach; Laurent Meijer; Jean-François Riou; Eric Henon; Janos Sapi
Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation.
Organic & biomolecular chemistry 2010;8(20):4625-36.
2010: Antonin Schmitt; Laurence Gladieff; Céline M Laffont; Alexandre Evrard; Jean-Christophe Boyer; Amélie Lansiaux; Christine Bobin-Dubigeon; Marie-Christine Etienne-Grimaldi; Michèle Boisdron-Celle; Mireille Mousseau; Frédéric Pinguet; Anne Floquet; Eliane M Billaud; Catherine Durdux; Chantal Le Guellec; Julien Mazières; Thierry Lafont; Florent Ollivier; Didier Concordet; Etienne Chatelut
Factors for hematopoietic toxicity of carboplatin: refining the targeting of carboplatin systemic exposure.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(30):4568-74.
2010: Julien Debray; Walid Zeghida; Brigitte Baldeyrou; Christine Mahieu; Amélie Lansiaux; Martine Demeunynck
Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives.
Bioorganic & medicinal chemistry letters 2010;20(14):4244-7.
2010: Elen Mello de Souza; A S G Nefertiti; C Bailly; Amélie Lansiaux; M N C Soeiro
Differential apoptosis-like cell death in amastigote and trypomastigote forms from Trypanosoma cruzi-infected heart cells in vitro.
Cell and tissue research 2010;341(1):173-80.
2009: Paul Peixoto; Walid Zeghida; Danièle Carrez; Ting-Di Wu; Nicole Wattez; Alain Croisy; Martine Demeunynck; Jean-Luc Guerquin-Kern; Amélie Lansiaux
Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
European journal of medicinal chemistry 2009;44(11):4758-63.
2009: Anne Beauchard; Alexis Jaunet; Laurence MURILLO; Brigitte Baldeyrou; Amélie Lansiaux; Jean-René Chérouvrier; Lisianne Domon; Laurent Picot; Christian Bailly; Thierry Besson; Valérie Thiéry
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
European journal of medicinal chemistry 2009;44(10):3858-65.
2009: Antonin Schmitt; Laurence Gladieff; Amélie Lansiaux; Christine Bobin-Dubigeon; Marie-Christine Etienne-Grimaldi; Michèle Boisdron-Celle; Françoise Serre-Debauvais; Frédéric Pinguet; Anne Floquet; Eliane Billaud; Chantal Le Guellec; Nicolas Penel; Mario Campone; Rémy Largillier; Olivier Capitain; Michel Fabbro; Nadine Houede; Jacques Medioni; PHILIPPE BOUGNOUX; Isabelle Lochon; Etienne Chatelut
A universal formula based on cystatin C to perform individual dosing of carboplatin in normal weight, underweight, and obese patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3633-9.
2009: Pierre Vekhoff; Ludovic Halby; Kahina Oussedik; Sabrina Dallavalle; Lucio Merlini; Christine Mahieu; Amélie Lansiaux; Christian Bailly; Alexandre Boutorine; Claudio Pisano; Giuseppe Giannini; Domenico Alloatti; Paola B Arimondo
Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan.
Bioconjugate chemistry 2009;20(4):666-72.
2009: Quyên Do; Wen Tian; Rodrigue Yougnia; Thomas Gaslonde; Bruno Pfeiffer; Alain Pierré; Stéphane Léonce; Laurence Kraus-Berthier; Marie-Hélène David-Cordonnier; Sabine Depauw; Amélie Lansiaux; Romain Mazinghien; Michel Koch; François Tillequin; Sylvie Michel; Hanh Dufat
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Bioorganic & medicinal chemistry 2009;17(5):1918-27.
2008: Jean-Marc Barret; Anna Kruczynski; Stéphane Vispé; Jean-Philippe Annereau; Viviane Brel; Yves Guminski; Jean-Guy Delcros; Amélie Lansiaux; Nicolas Guilbaud; Thierry Imbert; Christian Bailly
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
Cancer research 2008;68(23):9845-53.
2008: Adina Ryckebusch; Deborah Garcin; Amélie Lansiaux; Jean-François Goossens; Brigitte Baldeyrou; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.
Journal of medicinal chemistry 2008;51(12):3617-29.
2008: Aurélie Bourderioux; Valérie Bénéteau; Jean-Yves Mérour; Brigitte Baldeyrou; Caroline Ballot; Amélie Lansiaux; Christian Bailly; Rémy Le Guével; Christiane Guillouzo; Sylvain Routier
Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents.
Organic & biomolecular chemistry 2008;6(12):2108-17.
2008: Ulrich Jacquemard; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Cédric Logé; Jean-Michel Robert; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(9):4932-53.
2008: Nicolas Penel; Julia Saleron; Amélie Lansiaux; Stéphanie Clisant; Antoine Adenis; Charles Fournier; Alain Duhamel; Jacques Bonneterre
[Methodological approaches of clinical studies with targeted therapies].
Bulletin du cancer 2008;95(2):185-90.
2007: Nicolas Penel; Amélie Lansiaux; Antoine Adenis
Angiosarcomas and taxanes.
Current treatment options in oncology 2007;8(6):428-34.
2007: Manoj Munde; Mohamed A Ismail; Reem K Arafa; Paul Peixoto; Catharine J Collar; Yang Liu; Laixing Hu; Marie-Hélène David-Cordonnier; Amélie Lansiaux; Christian Bailly; David W Boykin; David W. Wilson
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Journal of the American Chemical Society 2007;129(44):13732-43.
2007: Amélie Lansiaux; Stéphane Léonce; Laurence Kraus-Berthier; Christine Bal-Mahieu; Romain Mazinghien; Sébastien Didier; Marie-Hélène David-Cordonnier; Patrick Hautefaye; Gilbert Lavielle; Christian Bailly; John A Hickman; Alain Pierré
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Molecular pharmacology 2007;72(2):311-9.
2007: Marie-Hélène David-Cordonnier; Marie-Paule Hildebrand; Brigitte Baldeyrou; Amélie Lansiaux; Christoph Keuser; Kerstin Benzschawel; Thomas Lemster; Ulf Pindur
Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.
European journal of medicinal chemistry 2007;42(6):752-71.
2007: Amélie Lansiaux; François Lokiec
[Pemetrexed: from preclinic to clinic].
Bulletin du cancer 2007;94 Spec No Actualites():S134-8.
2007: François Lokiec; Amélie Lansiaux
[Gemcitabine: from preclinic to clinic passing by pharmacokinetics].
Bulletin du cancer 2007;94 Spec No Actualites():S85-9.
2006: Jean-François Goossens; Christine Mahieu; Nathalie Dias; Christian Bailly; Paola Principe; Jean-Paul Bonte; Amélie Lansiaux; Claude Vaccher; Catherine Foulon
Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.
Electrophoresis 2006;27(23):4717-29.
2006: Laurent Bouffier; Brigitte Baldeyrou; Marie-Paule Hildebrand; Amélie Lansiaux; Marie-Hélène David-Cordonnier; Danièle Carrez; Alain Croisy; Olivier Renaudet; Pascal DUMY; Martine Demeunynck
Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding.
Bioorganic & medicinal chemistry 2006;14(22):7520-30.
2006: Stéphane Léonce; Laurence Kraus-Berthier; Roy M Golsteyn; Marie-Hélène David-Cordonnier; Christelle Tardy; Amélie Lansiaux; Virginie Poindessous; Annette K Larsen; Alain Pierré
Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.
Cancer research 2006;66(14):7203-10.
2006: Tuan Minh Nguyen; Chavalit Sittisombut; Sabrina Boutefnouchet; Marie-Christine Lallemand; Sylvie Michel; Michel Koch; François Tillequin; Romain Mazinghien; Amélie Lansiaux; Marie-Hélène David-Cordonnier; Bruno Pfeiffer; Laurence Kraus-Berthier; Stéphane Léonce; Alain Pierré
Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine.
Journal of medicinal chemistry 2006;49(11):3383-94.
2006: Sylvain Routier; Jean-Yves Mérour; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Olivier Lozach; Laurent Meijer
Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2006;49(2):789-99.
2006: Paul Peixoto; Amélie Lansiaux
[Histone-deacetylases inhibitors: from TSA to SAHA].
Bulletin du cancer 2006;93(1):27-36.
2006: Paola B Arimondo; Craig J Thomas; Kahina Oussedik; Brigitte Baldeyrou; Christine Mahieu; Ludovic Halby; Dominique Guianvarc'h; Amélie Lansiaux; Sidney Hecht; Christian Bailly; Carine Giovannangeli
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Molecular and cellular biology 2006;26(1):324-33.
2005: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Sylvain Routier; Jean-Yves Mérour
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
European journal of medicinal chemistry 2005;40(12):1206-13.
2005: jerome kluza; Romain Mazinghien; Klara Degardin; Amélie Lansiaux; Christian Bailly
Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species.
European journal of pharmacology 2005;525(1-3):32-40.
2005: Ulrich Jacquemard; Sylvain Routier; Nathalie Dias; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Jean-Yves Mérour
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
European journal of medicinal chemistry 2005;40(11):1087-95.
2005: Nathalie Dias; Jean-François Goossens; Brigitte Baldeyrou; Amélie Lansiaux; Pierre Colson; Alberto Di Salvo; Jeanne Bernal; Agnes Turnbull; David J Mincher; Christian Bailly
Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents.
Bioconjugate chemistry 2005;16(4):949-58.
2005: Esther Marco; William Laine; Christelle Tardy; Amélie Lansiaux; Masatomo Iwao; Fumito Ishibashi; Christian Bailly; Federico Gago
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Journal of medicinal chemistry 2005;48(11):3796-807.
2005: Marie Vanhuyse; jerome kluza; Christelle Tardy; Gabriel Otero; Carmen Cuevas; Christian Bailly; Amélie Lansiaux
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Cancer letters 2005;221(2):165-75.
2005: Jamal Tazi; Nadia Bakkour; Johann Soret; Latifa Zekri; Banasri Hazra; William Laine; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives.
Molecular pharmacology 2005;67(4):1186-94.
2005: M Laronze; M Boisbrun; Stéphane Léonce; B Pfeiffer; P Renard; O Lozach; L Meijer; Amélie Lansiaux; C Bailly; Janos Sapi; Jean-Yves Laronze
Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.
Bioorganic & medicinal chemistry 2005;13(6):2263-83.
2005: Christian Bailly; Reem K Arafa; Farial A Tanious; William Laine; Christelle Tardy; Amélie Lansiaux; Pierre Colson; David W Boykin; David W. Wilson
Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.
Biochemistry 2005;44(6):1941-52.
2005: Marie-Hélène David-Cordonnier; William Laine; Amélie Lansiaux; Frédéric Rosu; Pierre Colson; Edwin De Pauw; Sylvie Michel; François Tillequin; Michel Koch; John A Hickman; Alain Pierré; Christian Bailly
Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.
Molecular cancer therapeutics 2005;4(1):71-80.
2004: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Christelle Tardy; Amélie Lansiaux; Pierre Colson; Farial A Tanious; David W. Wilson; Sylvain Routier; Jean-Yves Mérour; Christian Bailly
Targeting DNA with novel diphenylcarbazoles.
Biochemistry 2004;43(48):15169-78.
2004: Christine Bal; Brigitte Baldeyrou; Florence Moz; Amélie Lansiaux; Pierre Colson; Laurence Kraus-Berthier; Stéphane Léonce; Alain Pierré; Marie-Françoise Boussard; Anne Rousseau; Michel Wierzbicki; Christian Bailly
Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.
Biochemical pharmacology 2004;68(10):1911-22.
2004: Elen Mello de Souza; Andrea Henriques-Pons; Christian Bailly; Amélie Lansiaux; Tania C Araújo-Jorge; Maria de Nazaré Correia Soeiro
In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury.
Memórias do Instituto Oswaldo Cruz 2004;99(7):697-701.
2004: Elen Mello de Souza; Amélie Lansiaux; C Bailly; David W. Wilson; Qiyue Hu; David W Boykin; Marcos Meuser Batista; Tania C Araújo-Jorge; M N C Soeiro
Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.
Biochemical pharmacology 2004;68(4):593-600.
2004: Soizic Prado; Sylvie Michel; François Tillequin; Michel Koch; Bruno Pfeiffer; Alain Pierré; Stéphane Léonce; Pierre Colson; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
Bioorganic & medicinal chemistry 2004;12(14):3943-53.
2004: Sara Hoet; Caroline Stévigny; Sébastien Block; Fred R Opperdoes; Pierre Colson; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly; Joëlle Quetin-Leclercq
Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases.
Planta medica 2004;70(5):407-13.
2004: Stéphanie Solier; Amélie Lansiaux; Emmanuelle Logette; Jane Wu; Johann Soret; Jamal Tazi; Christian Bailly; Lydie Desoche; Eric Solary; Laurent Corcos
Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.
Molecular cancer research : MCR 2004;2(1):53-61.
2003: Elen Mello de Souza; Tania C Araújo-Jorge; C Bailly; Amélie Lansiaux; Marcos Meuser Batista; Gabriel M Oliveira; M N C Soeiro
Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models.
Cell and tissue research 2003;314(2):223-35.
2003: Christian Bailly; Carolina Carrasco; Alexandra Joubert; Christine Bal; Nicole Wattez; Marie-Paule Hildebrand; Amélie Lansiaux; Pierre Colson; Claude Houssier; Mónica Cacho; Ana Ramos; Miguel F Braña
Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides.
Biochemistry 2003;42(14):4136-50.
2003: Franck Charmantray; Martine Demeunynck; Danièle Carrez; Alain Croisy; Amélie Lansiaux; Christian Bailly; Pierre Colson
4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents.
Journal of medicinal chemistry 2003;46(6):967-77.
2003: Amélie Lansiaux; Christian Bailly
[A symphony for the camptothecins].
Bulletin du cancer 2003;90(3):239-45.
2003: Carolina Carrasco; Philippe Helissey; Michelyne Haroun; Brigitte Baldeyrou; Amélie Lansiaux; Pierre Colson; Claude Houssier; Sylviane Giorgi-Renault; Christian Bailly
Design of a composite ethidium-netropsin-anilinoacridine molecule for DNA recognition.
Chembiochem : a European journal of chemical biology 2003;4(1):50-61.
2003: Amélie Lansiaux; Christian Bailly
[Perspectives on the oncologist pharmacopoeia].
Bulletin du cancer 2003;90(1):25-30.
2002: Amélie Lansiaux; Farial A Tanious; Zohar Mishal; Laurent Dassonneville; Arvind Kumar; Chad E Stephens; Qiyue Hu; David W. Wilson; David W Boykin; Christian Bailly
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Cancer research 2002;62(24):7219-29.
2002: Marie-Hélène David-Cordonnier; William Laine; Amélie Lansiaux; Mostafa Kouach; Gilbert Briand; Alain Pierré; John A Hickman; Christian Bailly
Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine.
Biochemistry 2002;41(31):9911-20.
2002: Amélie Lansiaux; Christian Bailly; Claude Houssier; Pierre Colson; Marie-Claire De Pauw-Gillet; Michel Frederich; Monique Tits; Luc Angenot
Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja.
Planta medica 2002;68(7):591-5.
2002: Amélie Lansiaux; Armelle Caty; Nathalie Deligny; Christian Bailly
[Cl958].
Bulletin du cancer 2002;89(6):575-8.
2002: Amélie Lansiaux; Laurent Dassonneville; Michaël Facompré; Arvind Kumar; Chad E Stephens; Miroslav Bajic; Farial A Tanious; David W. Wilson; David W Boykin; Christian Bailly
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
Journal of medicinal chemistry 2002;45(10):1994-2002.
2002: jerome kluza; Amélie Lansiaux; Nicole Wattez; Marie-Paule Hildebrand; Stéphane Léonce; Alain Pierré; John A Hickman; Christian Bailly
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.
Biochemical pharmacology 2002;63(8):1443-52.
2001: Amélie Lansiaux; Michaël Facompré; Nicole Wattez; Marie-Paule Hildebrand; Christine Bal; Danièle Demarquay; Olivier Lavergne; Dennis Bigg; Christian Bailly
Apoptosis induced by the homocamptothecin anticancer drug BN80915 in HL-60 cells.
Molecular pharmacology 2001;60(3):450-61.
2001: Amélie Lansiaux; R A Bras-Goncalves; Christophe Rosty; P Laurent-Puig; Marie-France Poupon; Christian Bailly
Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11.
Anticancer research 2001;21(1A):471-6.
2001: Amélie Lansiaux; William Laine; Brigitte Baldeyrou; Christine Mahieu; Nicole Wattez; Hervé Vezin; Fernando J Martinez; A Piñeyro; Christian Bailly
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
Chemical research in toxicology 2001;14(1):16-24.
2000: Laurent Dassonneville; Amélie Lansiaux; A Wattelet; Nicole Wattez; Christine Mahieu; Sabine van Miert; Luc Pieters; Christian Bailly
Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis.
European journal of pharmacology 2000;409(1):9-18.
2000: Amélie Lansiaux; Christian Bailly
[Flavopiridol, a cyclin-dependent kinase inhibitor].
Bulletin du cancer 2000;87(10):697-701.
2000: Laurent Dassonneville; Nicole Wattez; Brigitte Baldeyrou; Christine Mahieu; Amélie Lansiaux; Bernard Banaigs; Isabelle Bonnard; Christian Bailly
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
Biochemical pharmacology 2000;60(4):527-37.
2000: jerome kluza; Amélie Lansiaux; Nicole Wattez; Christine Mahieu; N Osheroff; Christian Bailly
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103.
Cancer research 2000;60(15):4077-84.
2000: Michaël Facompré; Nicole Wattez; jerome kluza; Amélie Lansiaux; Christian Bailly
Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide.
Molecular cell biology research communications : MCBRC 2000;4(1):37-42.
2000: Amélie Lansiaux; Christian Bailly
[JM216, an orally active platine derivative].
Bulletin du cancer 2000;87(7-8):531-6.
2000: Christian Bailly; Amélie Lansiaux
[An angiogenesis inhibitor: TNP-470].
Bulletin du cancer 2000;87(6):449-54.
2000: Amélie Lansiaux; P Formstecher; Christian Bailly
[LGD1069: an antagonist to the X retinoid receptor].
Bulletin du cancer 2000;87(3):235-8.
1999: Amélie Lansiaux; A Adams; W A Denny; Christian Bailly
[The DACA].
Bulletin du cancer 1999;86(12):971-5.
1999: Christian Bailly; Amélie Lansiaux; Laurent Dassonneville; Danièle Demarquay; Hélène Coulomb; Marion Huchet; Olivier Lavergne; Dennis Bigg
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.
Biochemistry 1999;38(47):15556-63.
1999: Amélie Lansiaux; Christian Bailly
[Dolastatins].
Bulletin du cancer 1999;86(11):897-901.
1999: Amélie Lansiaux; M Degardin; Christian Bailly
[LY231514. A multitargeted antifolate (MTA)].
Bulletin du cancer 1999;86(9):727-31.
1999: Amélie Lansiaux; D Fabbro; T Meyer; F Hamy; Christian Bailly
[PKC 412].
Bulletin du cancer 1999;86(7-8):614-7.
1999: Amélie Lansiaux; Christian Bailly
[NB 506].
Bulletin du cancer 1999;86(3):255-8.
1999: Amélie Lansiaux; Christian Bailly
[Ecteinascidin 743].
Bulletin du cancer 1999;86(2):139-41.