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Janos Lanyi

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TOP 3
Joel E Morgan; Ahmet S Vakkasoglu; Robert B Gennis; Janos K Lanyi; Johan Lugtenburg; Akio Maeda
Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle.
Sergei P Balashov; Andrei K Dioumaev; D A Dolgikh; Eleonora S Imasheva; M P Kirpichnikov; E P Lukashev; L E Petrovskaya; A B Rubin; S V Sychev; Jennifer M Wang; Janos K Lanyi
Aspartate-histidine interaction in the retinal schiff base counterion of the light-driven proton pump of Exiguobacterium sibiricum.
Venkatramanan Krishnamani; Janos K Lanyi
Molecular dynamics simulation of the unfolding of individual bacteriorhodopsin helices in sodium dodecyl sulfate micelles.

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2012: Joel E Morgan; Ahmet S Vakkasoglu; Robert B Gennis; Janos K Lanyi; Johan Lugtenburg; Akio Maeda
Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle.
Biophysical journal 2012;103(3):444-52.
2012: Sergei P Balashov; Andrei K Dioumaev; D A Dolgikh; Eleonora S Imasheva; M P Kirpichnikov; E P Lukashev; L E Petrovskaya; A B Rubin; S V Sychev; Jennifer M Wang; Janos K Lanyi
Aspartate-histidine interaction in the retinal schiff base counterion of the light-driven proton pump of Exiguobacterium sibiricum.
Biochemistry 2012;51(29):5748-62.
2012: Venkatramanan Krishnamani; Janos K Lanyi
Molecular dynamics simulation of the unfolding of individual bacteriorhodopsin helices in sodium dodecyl sulfate micelles.
Biochemistry 2012;51(6):1061-9.
2012: Venkatramanan Krishnamani; Ralf Langen; Balachandra G Hegde; Janos K Lanyi
Secondary and tertiary structure of bacteriorhodopsin in the SDS denatured state.
Biochemistry 2012;51(6):1051-60.
2011: Venkatramanan Krishnamani; Janos K Lanyi
Structural changes in bacteriorhodopsin during in vitro refolding from a partially denatured state.
Biophysical journal 2011;100(6):1559-67.
2011: Eleonora S Imasheva; Sergei P Balashov; Jennifer M Wang; Janos K Lanyi
Removal and reconstitution of the carotenoid antenna of xanthorhodopsin.
The Journal of membrane biology 2011;239(1-2):95-104.
2010: Sergei P Balashov; Eleonora S Imasheva; Ah Reum Choi; Kwang-Hwan Jung; Synnøve Liaaen-Jensen; Janos K Lanyi
Reconstitution of gloeobacter rhodopsin with echinenone: role of the 4-keto group.
Biochemistry 2010;49(45):9792-9.
2010: Joel E Morgan; Ahmet S Vakkasoglu; Janos K Lanyi; Robert B Gennis; Akio Maeda
Coordinating the structural rearrangements associated with unidirectional proton transfer in the bacteriorhodopsin photocycle induced by deprotonation of the proton-release group: a time-resolved difference FTIR spectroscopic study.
Biochemistry 2010;49(15):3273-81.
2010: Andrei K Dioumaev; Jennifer M Wang; Janos K Lanyi
Low-temperature FTIR study of multiple K intermediates in the photocycles of bacteriorhodopsin and xanthorhodopsin.
The journal of physical chemistry. B 2010;114(8):2920-31.
2009: Andrei K Dioumaev; Janos K Lanyi
Two bathointermediates of the bacteriorhodopsin photocycle, from time-resolved nanosecond spectra in the visible.
The journal of physical chemistry. B 2009;113(52):16643-53.
2009: Eleonora S Imasheva; Sergei P Balashov; Ah Reum Choi; Kwang-Hwan Jung; Janos K Lanyi
Reconstitution of Gloeobacter violaceus rhodopsin with a light-harvesting carotenoid antenna.
Biochemistry 2009;48(46):10948-55.
2009: Teruhisa Hirai; Sriram Subramaniam; Janos K Lanyi
Structural snapshots of conformational changes in a seven-helix membrane protein: lessons from bacteriorhodopsin.
Current opinion in structural biology 2009;19(4):433-9.
2009: Deliang Chen; Janos K Lanyi
Structural changes in the N and N' states of the bacteriorhodopsin photocycle.
Biophysical journal 2009;96(7):2779-88.
2009: Tomás Polívka; Sergei P Balashov; Pavel Chábera; Eleonora S Imasheva; Arkady Yartsev; Villy Sundström; Janos K Lanyi
Femtosecond carotenoid to retinal energy transfer in xanthorhodopsin.
Biophysical journal 2009;96(6):2268-77.
2009: Andrei K Dioumaev; Janos K Lanyi
Infrared monitoring of interlayer water in stacks of purple membranes.
Photochemistry and photobiology 2009;85(2):598-608.
2008: Hartmut Luecke; Brigitte Schobert; Jason Stagno; Eleonora S Imasheva; Jennifer M Wang; Sergei P Balashov; Janos K Lanyi
Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16561-5.
2008: Andrei K Dioumaev; Janos K Lanyi
Switch from conventional to distributed kinetics in the bacteriorhodopsin photocycle.
Biochemistry 2008;47(42):11125-33.
2008: Sergei P Balashov; Eleonora S Imasheva; Jennifer M Wang; Janos K Lanyi
Excitation energy-transfer and the relative orientation of retinal and carotenoid in xanthorhodopsin.
Biophysical journal 2008;95(5):2402-14.
2008: Janos K Lanyi; Sergei P Balashov
Xanthorhodopsin: a bacteriorhodopsin-like proton pump with a carotenoid antenna.
Biochimica et biophysica acta 2008;1777(7-8):684-8.
2008: Eleonora S Imasheva; Sergei P Balashov; Jennifer M Wang; Elena Smolensky; Mordechai Sheves; Janos K Lanyi
Chromophore interaction in xanthorhodopsin--retinal dependence of salinixanthin binding.
Photochemistry and photobiology 2008;84(4):977-84.
2007: Sergei P Balashov; Janos K Lanyi
Xanthorhodopsin: Proton pump with a carotenoid antenna.
Cellular and molecular life sciences : CMLS 2007;64(18):2323-8.
2007: Andrei K Dioumaev; Janos K Lanyi
Bacteriorhodopsin photocycle at cryogenic temperatures reveals distributed barriers of conformational substates.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9621-6.
2007: Deliang Chen; Jennifer M Wang; Janos K Lanyi
Electron paramagnetic resonance study of structural changes in the O photointermediate of bacteriorhodopsin.
Journal of molecular biology 2007;366(3):790-805.
2007: Janos K Lanyi; Brigitte Schobert
Structural changes in the L photointermediate of bacteriorhodopsin.
Journal of molecular biology 2007;365(5):1379-92.
2007: Janos K Lanyi
Studies of the bacteriorhodopsin photocycle without the use of light: clues to proton transfer coupled reactions.
Journal of molecular microbiology and biotechnology 2007;12(3-4):210-7.
2006: Vladimir A Boichenko; Jennifer M Wang; Josefa Antón; Janos K Lanyi; Sergei P Balashov
Functions of carotenoids in xanthorhodopsin and archaerhodopsin, from action spectra of photoinhibition of cell respiration.
Biochimica et biophysica acta 2006;1757(12):1649-56.
2006: Eleonora S Imasheva; Sergei P Balashov; Jennifer M Wang; Janos K Lanyi
pH-dependent transitions in xanthorhodopsin.
Photochemistry and photobiology 2006;82(6):1406-13.
2006: Janos K Lanyi; Brigitte Schobert
Propagating structural perturbation inside bacteriorhodopsin: crystal structures of the M state and the D96A and T46V mutants.
Biochemistry 2006;45(39):12003-10.
2006: Sergei P Balashov; Eleonora S Imasheva; Janos K Lanyi
Induced chirality of the light-harvesting carotenoid salinixanthin and its interaction with the retinal of xanthorhodopsin.
Biochemistry 2006;45(36):10998-1004.
2006: Janos K Lanyi
Proton transfers in the bacteriorhodopsin photocycle.
Biochimica et biophysica acta 2006;1757(8):1012-8.
2006: László Zimányi; Jack Saltiel; Leonid S Brown; Janos K Lanyi
A priori resolution of the intermediate spectra in the bacteriorhodopsin photocycle: the time evolution of the L spectrum revealed.
The journal of physical chemistry. A 2006;110(7):2318-21.
2005: Sergei P Balashov; Eleonora S Imasheva; Vladimir A Boichenko; Josefa Antón; Jennifer M Wang; Janos K Lanyi
Xanthorhodopsin: a proton pump with a light-harvesting carotenoid antenna.
Science (New York, N.Y.) 2005;309(5743):2061-4.
2005: Eleonora S Imasheva; Kazumi Shimono; Sergei P Balashov; Jennifer M Wang; Uri Zadok; Mordechai Sheves; Naoki Kamo; Janos K Lanyi
Formation of a long-lived photoproduct with a deprotonated Schiff base in proteorhodopsin, and its enhancement by mutation of Asp227.
Biochemistry 2005;44(32):10828-38.
2005: Florian Garczarek; Leonid S Brown; Janos K Lanyi; Klaus Gerwert
Proton binding within a membrane protein by a protonated water cluster.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3633-8.
2004: Janos K Lanyi
What is the real crystallographic structure of the L photointermediate of bacteriorhodopsin?
Biochimica et biophysica acta 2004;1658(1-2):14-22.
2004: Janos K Lanyi
X-ray diffraction of bacteriorhodopsin photocycle intermediates.
Molecular membrane biology 2004;21(3):143-50.
2004: Zoltán Bálint; Melinda Lakatos; Constanta Ganea; Janos K Lanyi; György Váró
The nitrate transporting photochemical reaction cycle of the pharaonis halorhodopsin.
Biophysical journal 2004;86(3):1655-63.
2004: Eleonora S Imasheva; Sergei P Balashov; Jennifer M Wang; Andrei K Dioumaev; Janos K Lanyi
Selectivity of retinal photoisomerization in proteorhodopsin is controlled by aspartic acid 227.
Biochemistry 2004;43(6):1648-55.
2004: Janos K Lanyi; Brigitte Schobert
Local-global conformational coupling in a heptahelical membrane protein: transport mechanism from crystal structures of the nine states in the bacteriorhodopsin photocycle.
Biochemistry 2004;43(1):3-8.
2004: Janos K Lanyi
Bacteriorhodopsin.
Annual review of physiology 2004;66():665-88.
2003: Brigitte Schobert; Leonid S Brown; Janos K Lanyi
Crystallographic structures of the M and N intermediates of bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base.
Journal of molecular biology 2003;330(3):553-70.
2003: Andrei K Dioumaev; Jennifer M Wang; Zoltán Bálint; György Váró; Janos K Lanyi
Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic.
Biochemistry 2003;42(21):6582-7.
2003: Melinda Lakatos; Janos K Lanyi; Juliánna Szakács; György Váró
The photochemical reaction cycle of proteorhodopsin at low pH.
Biophysical journal 2003;84(5):3252-6.
2003: Janos K Lanyi; Brigitte Schobert
Mechanism of proton transport in bacteriorhodopsin from crystallographic structures of the K, L, M1, M2, and M2' intermediates of the photocycle.
Journal of molecular biology 2003;328(2):439-50.
2003: György Váró; Leonid S Brown; Melinda Lakatos; Janos K Lanyi
Characterization of the photochemical reaction cycle of proteorhodopsin.
Biophysical journal 2003;84(2 Pt 1):1202-7.
2003: Hartmut Luecke; Janos K Lanyi
Structural clues to the mechanism of ion pumping in bacteriorhodopsin.
Advances in protein chemistry 2003;63():111-30.
2002: Janos K Lanyi; Brigitte Schobert
Crystallographic structure of the retinal and the protein after deprotonation of the Schiff base: the switch in the bacteriorhodopsin photocycle.
Journal of molecular biology 2002;321(4):727-37.
2002: Brigitte Schobert; Jill R Cupp-Vickery; Viktor Hornak; Steven Smith; Janos K Lanyi
Crystallographic structure of the K intermediate of bacteriorhodopsin: conservation of free energy after photoisomerization of the retinal.
Journal of molecular biology 2002;321(4):715-26.
2002: Shinji Hashimoto; Masato Sasaki; Hideo Takeuchi; Richard Needleman; Janos K Lanyi
Changes in hydrogen bonding and environment of tryptophan residues on helix F of bacteriorhodopsin during the photocycle: a time-resolved ultraviolet resonance Raman study.
Biochemistry 2002;41(20):6495-503.
2002: Andrei K Dioumaev; Leonid S Brown; Jennifer Shih; Elena N Spudich; John L Spudich; Janos K Lanyi
Proton transfers in the photochemical reaction cycle of proteorhodopsin.
Biochemistry 2002;41(17):5348-58.
2002: Melinda Lakatos; Géza I Groma; Constanta Ganea; Janos K Lanyi; György Váró
Characterization of the azide-dependent bacteriorhodopsin-like photocycle of salinarum halorhodopsin.
Biophysical journal 2002;82(4):1687-95.
2002: Leonid S Brown; Richard Needleman; Janos K Lanyi
Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin.
Journal of molecular biology 2002;317(3):471-8.
2001: Janos K Lanyi
X-ray crystallography of bacteriorhodopsin and its photointermediates: insights into the mechanism of proton transport.
Biochemistry. Biokhimii͡a 2001;66(11):1192-6.
2001: Shahab Rouhani; Jean-Philippe Cartailler; Marc T Facciotti; Peter J Walian; Richard Needleman; Janos K Lanyi; Robert M Glaeser; Hartmut Luecke
Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.
Journal of molecular biology 2001;313(3):615-28.
2001: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Coupling of the reisomerization of the retinal, proton uptake, and reprotonation of Asp-96 in the N photointermediate of bacteriorhodopsin.
Biochemistry 2001;40(38):11308-17.
2001: Leonid S Brown; Andrei K Dioumaev; Janos K Lanyi; Elena N Spudich; John L Spudich
Photochemical reaction cycle and proton transfers in Neurospora rhodopsin.
The Journal of biological chemistry 2001;276(35):32495-505.
2001: Hartmut Luecke; Brigitte Schobert; Janos K Lanyi; Elena N Spudich; John L Spudich
Crystal structure of sensory rhodopsin II at 2.4 angstroms: insights into color tuning and transducer interaction.
Science (New York, N.Y.) 2001;293(5534):1499-503.
2001: Janos K Lanyi; Hartmut Luecke
Bacteriorhodopsin.
Current opinion in structural biology 2001;11(4):415-9.
2001: Satoru Yamaguchi; Koka Yonebayashi; H Konishi; Satoru Tuzi; Akira Naito; Janos K Lanyi; Richard Needleman; Hazime Saitô
Cytoplasmic surface structure of bacteriorhodopsin consisting of interhelical loops and C-terminal alpha helix, modified by a variety of environmental factors as studied by (13)C-NMR.
European journal of biochemistry / FEBS 2001;268(8):2218-28.
2001: Satoru Yamaguchi; Satoru Tuzi; Koka Yonebayashi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Surface dynamics of bacteriorhodopsin as revealed by (13)C NMR studies on [(13)C]Ala-labeled proteins: detection of millisecond or microsecond motions in interhelical loops and C-terminal alpha-helix.
Journal of biochemistry 2001;129(3):373-82.
2000: wenzhong xiao; Leonid S Brown; Richard Needleman; Janos K Lanyi; YK Shin
Light-induced rotation of a transmembrane alpha-helix in bacteriorhodopsin.
Journal of molecular biology 2000;304(5):715-21.
2000: Y Kawase; Michikazu Tanio; Atushi Kira; Satoru Yamaguchi; Satoru Tuzi; Akira Naito; M Kataoka; Janos K Lanyi; Richard Needleman; Hazime Saitô
Alteration of conformation and dynamics of bacteriorhodopsin induced by protonation of Asp 85 and deprotonation of Schiff base as studied by 13C NMR.
Biochemistry 2000;39(47):14472-80.
2000: A Kulcsár; Géza I Groma; Janos K Lanyi; György Váró
Characterization of the proton-transporting photocycle of pharaonis halorhodopsin.
Biophysical journal 2000;79(5):2705-13.
2000: Janos K Lanyi
Crystallographic studies of the conformational changes that drive directional transmembrane ion movement in bacteriorhodopsin.
Biochimica et biophysica acta 2000;1459(2-3):339-45.
2000: Hartmut Luecke; Brigitte Schobert; Jean-Philippe Cartailler; HT Richter; Anja Rosengarth; Richard Needleman; Janos K Lanyi
Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin.
Journal of molecular biology 2000;300(5):1237-55.
2000: Satoru Yamaguchi; Satoru Tuzi; Michikazu Tanio; Akira Naito; Janos K Lanyi; Richard Needleman; Hazime Saitô
Irreversible conformational change of bacterio-opsin induced by binding of retinal during its reconstitution to bacteriorhodopsin, as studied by (13)C NMR.
Journal of biochemistry 2000;127(5):861-9.
2000: Hideki Kandori; N Kinoshita; Y Yamazaki; A Maeda; Yoshinori Shichida; Richard Needleman; Janos K Lanyi; M Bizounok; Judith Herzfeld; Jan Raap; Johan Lugtenburg
Local and distant protein structural changes on photoisomerization of the retinal in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4643-8.
2000: Leonid S Brown; Richard Needleman; Janos K Lanyi
Origins of deuterium kinetic isotope effects on the proton transfers of the bacteriorhodopsin photocycle.
Biochemistry 2000;39(5):938-45.
2000: K Ludmann; G Ibron; Janos K Lanyi; György Váró
Charge motions during the photocycle of pharaonis halorhodopsin.
Biophysical journal 2000;78(2):959-66.
1999: Janos K Lanyi
Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin.
FEBS letters 1999;464(3):103-7.
1999: Hartmut Luecke; Brigitte Schobert; HT Richter; Jean-Philippe Cartailler; Janos K Lanyi
Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution.
Science (New York, N.Y.) 1999;286(5438):255-61.
1999: Michikazu Tanio; Satoru Tuzi; Satoru Yamaguchi; R Kawaminami; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Conformational changes of bacteriorhodopsin along the proton-conduction chain as studied with (13)C NMR of [3-(13)C]Ala-labeled protein: arg(82) may function as an information mediator.
Biophysical journal 1999;77(3):1577-84.
1999: Hartmut Luecke; Brigitte Schobert; HT Richter; Jean-Philippe Cartailler; Janos K Lanyi
Structure of bacteriorhodopsin at 1.55 A resolution.
Journal of molecular biology 1999;291(4):899-911.
1999: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Fourier transform infrared spectra of a late intermediate of the bacteriorhodopsin photocycle suggest transient protonation of Asp-212.
Biochemistry 1999;38(31):10070-8.
1999: Hideki Kandori; N Kinoshita; Y Yamazaki; A Maeda; Yoshinori Shichida; Richard Needleman; Janos K Lanyi; M Bizounok; Judith Herzfeld; Jan Raap; Johan Lugtenburg
Structural change of threonine 89 upon photoisomerization in bacteriorhodopsin as revealed by polarized FTIR spectroscopy.
Biochemistry 1999;38(30):9676-83.
1999: Y S Chon; Hideki Kandori; Jun Sasaki; Janos K Lanyi; Richard Needleman; A Maeda
Existence of two L photointermediates of halorhodopsin from Halobacterium salinarium, differing in their protein and water FTIR bands.
Biochemistry 1999;38(29):9449-55.
1999: Michikazu Tanio; S Inoue; K Yokota; T Seki; Satoru Tuzi; Richard Needleman; Janos K Lanyi; Akira Naito; Hazime Saitô
Long-distance effects of site-directed mutations on backbone conformation in bacteriorhodopsin from solid state NMR of [1-13C]Val-labeled proteins.
Biophysical journal 1999;77(1):431-42.
1999: György Váró; Leonid S Brown; Richard Needleman; Janos K Lanyi
Binding of calcium ions to bacteriorhodopsin.
Biophysical journal 1999;76(6):3219-26.
1999: Leonid S Brown; Richard Needleman; Janos K Lanyi
Functional roles of aspartic acid residues at the cytoplasmic surface of bacteriorhodopsin.
Biochemistry 1999;38(21):6855-61.
1999: László Zimányi; A Kulcsár; Janos K Lanyi; Donald F Sears; Jack Saltiel
Intermediate spectra and photocycle kinetics of the Asp96 --> asn mutant bacteriorhodopsin determined by singular value decomposition with self-modeling.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4414-9.
1999: László Zimányi; A Kulcsár; Janos K Lanyi; Donald F Sears; Jack Saltiel
Singular value decomposition with self-modeling applied to determine bacteriorhodopsin intermediate spectra: analysis of simulated data.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4408-13.
1999: Satoru Tuzi; Satoru Yamaguchi; Michikazu Tanio; H Konishi; S Inoue; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Location of a cation-binding site in the loop between helices F and G of bacteriorhodopsin as studied by 13C NMR.
Biophysical journal 1999;76(3):1523-31.
1999: Toshihiko Oka; Hironari Kamikubo; Fumio Tokunaga; Janos K Lanyi; Richard Needleman; Mikio Kataoka
Conformational change of helix G in the bacteriorhodopsin photocycle: investigation with heavy atom labeling and x-ray diffraction.
Biophysical journal 1999;76(2):1018-23.
1999: Janos K Lanyi
Bacteriorhodopsin.
International review of cytology 1999;187():161-202.
1998: Janos K Lanyi
Understanding structure and function in the light-driven proton pump bacteriorhodopsin.
Journal of structural biology 1998;124(2-3):164-78.
1998: Michikazu Tanio; Satoru Tuzi; Satoru Yamaguchi; H Konishi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Evidence of local conformational fluctuations and changes in bacteriorhodopsin, dependent on lipids, detergents and trimeric structure, as studied by 13C NMR.
Biochimica et biophysica acta 1998;1375(1-2):84-92.
1998: Leonid S Brown; Andrei K Dioumaev; Richard Needleman; Janos K Lanyi
Connectivity of the retinal Schiff base to Asp85 and Asp96 during the bacteriorhodopsin photocycle: the local-access model.
Biophysical journal 1998;75(3):1455-65.
1998: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Partitioning of free energy gain between the photoisomerized retinal and the protein in bacteriorhodopsin.
Biochemistry 1998;37(28):9889-93.
1998: Hartmut Luecke; HT Richter; Janos K Lanyi
Proton transfer pathways in bacteriorhodopsin at 2.3 angstrom resolution.
Science (New York, N.Y.) 1998;280(5371):1934-7.
1998: Leonid S Brown; Andrei K Dioumaev; Richard Needleman; Janos K Lanyi
Local-access model for proton transfer in bacteriorhodopsin.
Biochemistry 1998;37(11):3982-93.
1998: Andrei K Dioumaev; HT Richter; Leonid S Brown; Michikazu Tanio; Satoru Tuzi; H Saito; Y Kimura; Richard Needleman; Janos K Lanyi
Existence of a proton transfer chain in bacteriorhodopsin: participation of Glu-194 in the release of protons to the extracellular surface.
Biochemistry 1998;37(8):2496-506.
1998: Y Yamazaki; Hideki Kandori; Richard Needleman; Janos K Lanyi; A Maeda
Interaction of the protonated Schiff base with the peptide backbone of valine 49 and the intervening water molecule in the N photointermediate of bacteriorhodopsin.
Biochemistry 1998;37(6):1559-64.
1998: Satoru Yamaguchi; Satoru Tuzi; T Seki; Michikazu Tanio; Richard Needleman; Janos K Lanyi; Akira Naito; Hazime Saitô
Stability of the C-terminal alpha-helical domain of bacteriorhodopsin that protrudes from the membrane surface, as studied by high-resolution solid-state 13C NMR.
Journal of biochemistry 1998;123(1):78-86.
1997: Janos K Lanyi
Mechanism of ion transport across membranes. Bacteriorhodopsin as a prototype for proton pumps.
The Journal of biological chemistry 1997;272(50):31209-12.
1997: Toshihiko Oka; Hironari Kamikubo; Fumio Tokunaga; Janos K Lanyi; Richard Needleman; Mikio Kataoka
X-ray diffraction studies of bacteriorhodopsin. Determination of the positions of mercury label at several engineered cysteine residues.
Photochemistry and photobiology 1997;66(6):768-73.
1997: TE Thorgeirsson; wenzhong xiao; Leonid S Brown; Richard Needleman; Janos K Lanyi; YK Shin
Transient channel-opening in bacteriorhodopsin: an EPR study.
Journal of molecular biology 1997;273(5):951-7.
1997: Hironari Kamikubo; Toshihiko Oka; Yasushi Imamoto; Fumio Tokunaga; Janos K Lanyi; Mikio Kataoka
The last phase of the reprotonation switch in bacteriorhodopsin: the transition between the M-type and the N-type protein conformation depends on hydration.
Biochemistry 1997;36(40):12282-7.
1997: Leonid S Brown; Hironari Kamikubo; László Zimányi; M Kataoka; Fumio Tokunaga; Peter J E Verdegem; Johan Lugtenburg; Janos K Lanyi
A local electrostatic change is the cause of the large-scale protein conformation shift in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5040-4.
1997: M Hatanaka; R Kashima; Hideki Kandori; N Friedman; M Sheves; Richard Needleman; Janos K Lanyi; A Maeda
Trp86 --> Phe replacement in bacteriorhodopsin affects a water molecule near Asp85 and light adaptation.
Biochemistry 1997;36(18):5493-8.
1997: Hideki Kandori; Y Yamazaki; M Hatanaka; Richard Needleman; Leonid S Brown; HT Richter; Janos K Lanyi; A Maeda
Time-resolved fourier transform infrared study of structural changes in the last steps of the photocycles of Glu-204 and Leu-93 mutants of bacteriorhodopsin.
Biochemistry 1997;36(17):5134-41.
1997: A Maeda; Hideki Kandori; Y Yamazaki; S Nishimura; M Hatanaka; Y S Chon; Jun Sasaki; Richard Needleman; Janos K Lanyi
Intramembrane signaling mediated by hydrogen-bonding of water and carboxyl groups in bacteriorhodopsin and rhodopsin.
Journal of biochemistry 1997;121(3):399-406.
1996: Leonid S Brown; Richard Needleman; Janos K Lanyi
Interaction of proton and chloride transfer pathways in recombinant bacteriorhodopsin with chloride transport activity: implications for the chloride translocation mechanism.
Biochemistry 1996;35(50):16048-54.
1996: HT Richter; Richard Needleman; Hideki Kandori; A Maeda; Janos K Lanyi
Relationship of retinal configuration and internal proton transfer at the end of the bacteriorhodopsin photocycle.
Biochemistry 1996;35(48):15461-6.
1996: HT Richter; Richard Needleman; Janos K Lanyi
Perturbed interaction between residues 85 and 204 in Tyr-185-->Phe and Asp-85-->Glu bacteriorhodopsins.
Biophysical journal 1996;71(6):3392-8.
1996: Y S Chon; Jun Sasaki; Hideki Kandori; Leonid S Brown; Janos K Lanyi; Richard Needleman; A Maeda
Hydration of the counterion of the Schiff base in the chloride-transporting mutant of bacteriorhodopsin: FTIR and FT-raman studies of the effects of anion binding when Asp85 is replaced with a neutral residue.
Biochemistry 1996;35(45):14244-50.
1996: Janos K Lanyi
Shuffling protons in bacteriorhodopsin: long-distance coupling between the pKas of two carboxylic groups.
Biophysical journal 1996;71(2):541-3.
1996: Satoru Tuzi; Satoru Yamaguchi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Conformation and dynamics of [3-13C]Ala- labeled bacteriorhodopsin and bacterioopsin, induced by interaction with retinal and its analogs, as studied by 13C nuclear magnetic resonance.
Biochemistry 1996;35(23):7520-7.
1996: G Váró; Leonid S Brown; Richard Needleman; Janos K Lanyi
Proton transport by halorhodopsin.
Biochemistry 1996;35(21):6604-11.
1996: M Hatanaka; Jun Sasaki; Hideki Kandori; T G Ebrey; Richard Needleman; Janos K Lanyi; A Maeda
Effects of arginine-82 on the interactions of internal water molecules in bacteriorhodopsin.
Biochemistry 1996;35(20):6308-12.
1996: Y Yamazaki; Satoru Tuzi; Hazime Saitô; Hideki Kandori; Richard Needleman; Janos K Lanyi; A Maeda
Hydrogen bonds of water and C==O groups coordinate long-range structural changes in the L photointermediate of bacteriorhodopsin.
Biochemistry 1996;35(13):4063-8.
1996: HT Richter; Leonid S Brown; Richard Needleman; Janos K Lanyi
A linkage of the pKa's of asp-85 and glu-204 forms part of the reprotonation switch of bacteriorhodopsin.
Biochemistry 1996;35(13):4054-62.
1996: Leonid S Brown; Janos K Lanyi
Determination of the transiently lowered pKa of the retinal Schiff base during the photocycle of bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1731-4.
1996: Hironari Kamikubo; M Kataoka; G Váró; Toshihiko Oka; Fumio Tokunaga; Richard Needleman; Janos K Lanyi
Structure of the N intermediate of bacteriorhodopsin revealed by x-ray diffraction.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1386-90.
1996: G Váró; Richard Needleman; Janos K Lanyi
Protein structural change at the cytoplasmic surface as the cause of cooperativity in the bacteriorhodopsin photocycle.
Biophysical journal 1996;70(1):461-7.
1995: Leonid S Brown; J Sasaki; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin.
The Journal of biological chemistry 1995;270(45):27122-6.
1995: G Váró; Richard Needleman; Janos K Lanyi
Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 2. Chloride release and uptake, protein conformation change, and thermodynamics.
Biochemistry 1995;34(44):14500-7.
1995: G Váró; Leonid S Brown; J Sasaki; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 1. The photochemical cycle.
Biochemistry 1995;34(44):14490-9.
1995: Leonid S Brown; G Váró; Richard Needleman; Janos K Lanyi
Functional significance of a protein conformation change at the cytoplasmic end of helix F during the bacteriorhodopsin photocycle.
Biophysical journal 1995;69(5):2103-11.
1995: Leonid S Brown; G Váró; M Hatanaka; J Sasaki; Hideki Kandori; A Maeda; N Friedman; Mordechai Sheves; R Nedleman; Janos K Lanyi
The complex extracellular domain regulates the deprotonation and reprotonation of the retinal Schiff base during the bacteriorhodopsin photocycle.
Biochemistry 1995;34(39):12903-11.
1995: G Váró; Janos K Lanyi
Effects of hydrostatic pressure on the kinetics reveal a volume increase during the bacteriorhodopsin photocycle.
Biochemistry 1995;34(38):12161-9.
1995: Jun Sasaki; Leonid S Brown; Y S Chon; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Conversion of bacteriorhodopsin into a chloride ion pump.
Science (New York, N.Y.) 1995;269(5220):73-5.
1995: Janos K Lanyi
Bacteriorhodopsin as a model for proton pumps.
Nature 1995;375(6531):461-3.
1995: G Váró; László Zimányi; X Fan; L Sun; Richard Needleman; Janos K Lanyi
Photocycle of halorhodopsin from Halobacterium salinarium.
Biophysical journal 1995;68(5):2062-72.
1995: Y Cao; Leonid S Brown; J Sasaki; A Maeda; Richard Needleman; Janos K Lanyi
Relationship of proton release at the extracellular surface to deprotonation of the schiff base in the bacteriorhodopsin photocycle.
Biophysical journal 1995;68(4):1518-30.
1995: Y Yamazaki; Jun Sasaki; M Hatanaka; Hideki Kandori; A Maeda; Richard Needleman; T Shinada; K Yoshihara; Leonid S Brown; Janos K Lanyi
Interaction of tryptophan-182 with the retinal 9-methyl group in the L intermediate of bacteriorhodopsin.
Biochemistry 1995;34(2):577-82.
1994: M Kataoka; Hironari Kamikubo; Fumio Tokunaga; Leonid S Brown; Y Yamazaki; A Maeda; M Sheves; Richard Needleman; Janos K Lanyi
Energy coupling in an ion pump. The reprotonation switch of bacteriorhodopsin.
Journal of molecular biology 1994;243(4):621-38.
1994: Leonid S Brown; Y Gat; Mordechai Sheves; Y Yamazaki; A Maeda; Richard Needleman; Janos K Lanyi
The retinal Schiff base-counterion complex of bacteriorhodopsin: changed geometry during the photocycle is a cause of proton transfer to aspartate 85.
Biochemistry 1994;33(40):12001-11.
1994: Leonid S Brown; Y Yamazaki; A Maeda; L Sun; Richard Needleman; Janos K Lanyi
The proton transfers in the cytoplasmic domain of bacteriorhodopsin are facilitated by a cluster of interacting residues.
Journal of molecular biology 1994;239(3):401-14.
1994: Jun Sasaki; Janos K Lanyi; Richard Needleman; T Yoshizawa; A Maeda
Complete identification of C = O stretching vibrational bands of protonated aspartic acid residues in the difference infrared spectra of M and N intermediates versus bacteriorhodopsin.
Biochemistry 1994;33(11):3178-84.
1994: A Maeda; Jun Sasaki; Y Yamazaki; Richard Needleman; Janos K Lanyi
Interaction of aspartate-85 with a water molecule and the protonated Schiff base in the L intermediate of bacteriorhodopsin: a Fourier-transform infrared spectroscopic study.
Biochemistry 1994;33(7):1713-7.
1993: Janos K Lanyi
Proton translocation mechanism and energetics in the light-driven pump bacteriorhodopsin.
Biochimica et biophysica acta 1993;1183(2):241-61.
1993: M Kataoka; K Mihara; Hironari Kamikubo; Richard Needleman; Janos K Lanyi; Fumio Tokunaga
Trimeric mutant bacteriorhodopsin, D85N, shows a monophasic CD spectrum.
FEBS letters 1993;333(1-2):111-3.
1993: Y Cao; Leonid S Brown; Richard Needleman; Janos K Lanyi
Relationship of proton uptake on the cytoplasmic surface and reisomerization of the retinal in the bacteriorhodopsin photocycle: an attempt to understand the complex kinetics of the pH changes and the N and O intermediates.
Biochemistry 1993;32(38):10239-48.
1993: Leonid S Brown; László Zimányi; Richard Needleman; Michael Ottolenghi; Janos K Lanyi
Photoreaction of the N intermediate of bacteriorhodopsin, and its relationship to the decay kinetics of the M intermediate.
Biochemistry 1993;32(30):7679-85.
1993: László Zimányi; Y Cao; Richard Needleman; Michael Ottolenghi; Janos K Lanyi
Pathway of proton uptake in the bacteriorhodopsin photocycle.
Biochemistry 1993;32(30):7669-78.
1993: Janos K Lanyi
Pathways of proton transfer in the light-driven pump bacteriorhodopsin.
Experientia 1993;49(6-7):514-7.
1993: Leonid S Brown; L Bonet; Richard Needleman; Janos K Lanyi
Estimated acid dissociation constants of the Schiff base, Asp-85, and Arg-82 during the bacteriorhodopsin photocycle.
Biophysical journal 1993;65(1):124-30.
1993: Y Cao; G Váró; A L Klinger; D M Czajkowsky; Mark S Braiman; Richard Needleman; Janos K Lanyi
Proton transfer from Asp-96 to the bacteriorhodopsin Schiff base is caused by a decrease of the pKa of Asp-96 which follows a protein backbone conformational change.
Biochemistry 1993;32(8):1981-90.
1993: László Zimányi; Janos K Lanyi
Deriving the intermediate spectra and photocycle kinetics from time-resolved difference spectra of bacteriorhodopsin. The simpler case of the recombinant D96N protein.
Biophysical journal 1993;64(1):240-51.
1992: László Zimányi; Y Cao; M Chang; B Ni; Richard Needleman; Janos K Lanyi
The two consecutive M substates in the photocycle of bacteriorhodopsin are affected specifically by the D85N and D96N residue replacements.
Photochemistry and photobiology 1992;56(6):1049-55.
1992: Jun Sasaki; Yoshinori Shichida; Janos K Lanyi; A Maeda
Protein changes associated with reprotonation of the Schiff base in the photocycle of Asp96-->Asn bacteriorhodopsin. The MN intermediate with unprotonated Schiff base but N-like protein structure.
The Journal of biological chemistry 1992;267(29):20782-6.
1992: László Zimányi; G Váró; M Chang; B Ni; Richard Needleman; Janos K Lanyi
Pathways of proton release in the bacteriorhodopsin photocycle.
Biochemistry 1992;31(36):8535-43.
1992: A Maeda; Jun Sasaki; Yoshinori Shichida; T Yoshizawa; M Chang; B Ni; Richard Needleman; Janos K Lanyi
Structures of aspartic acid-96 in the L and N intermediates of bacteriorhodopsin: analysis by Fourier transform infrared spectroscopy.
Biochemistry 1992;31(19):4684-90.
1992: Janos K Lanyi
The rhodopsins: structure and function. Introduction.
Journal of bioenergetics and biomembranes 1992;24(2):137-8.
1992: Janos K Lanyi
Proton transfer and energy coupling in the bacteriorhodopsin photocycle.
Journal of bioenergetics and biomembranes 1992;24(2):169-79.
1992: G Váró; László Zimányi; M Chang; B Ni; Richard Needleman; Janos K Lanyi
A residue substitution near the beta-ionone ring of the retinal affects the M substates of bacteriorhodopsin.
Biophysical journal 1992;61(3):820-6.
1992: Janos K Lanyi; J Tittor; G Váró; G Krippahl; D Oesterhelt
Influence of the size and protonation state of acidic residue 85 on the absorption spectrum and photoreaction of the bacteriorhodopsin chromophore.
Biochimica et biophysica acta 1992;1099(1):102-10.
1992: Janos K Lanyi
Reaction cycle and thermodynamics in bacteriorhodopsin.
Acta physiologica Scandinavica. Supplementum 1992;607():245-8.
1991: Y Cao; G Váró; M Chang; B F Ni; Richard Needleman; Janos K Lanyi
Water is required for proton transfer from aspartate-96 to the bacteriorhodopsin Schiff base.
Biochemistry 1991;30(45):10972-9.
1991: G Váró; Janos K Lanyi
Effects of the crystalline structure of purple membrane on the kinetics and energetics of the bacteriorhodopsin photocycle.
Biochemistry 1991;30(29):7165-71.
1991: Richard Needleman; M Chang; B Ni; G Váró; J Fornés; S H White; Janos K Lanyi
Properties of Asp212----Asn bacteriorhodopsin suggest that Asp212 and Asp85 both participate in a counterion and proton acceptor complex near the Schiff base.
The Journal of biological chemistry 1991;266(18):11478-84.
1991: G Váró; Janos K Lanyi
Thermodynamics and energy coupling in the bacteriorhodopsin photocycle.
Biochemistry 1991;30(20):5016-22.
1991: G Váró; Janos K Lanyi
Kinetic and spectroscopic evidence for an irreversible step between deprotonation and reprotonation of the Schiff base in the bacteriorhodopsin photocycle.
Biochemistry 1991;30(20):5008-15.
1991: G Váró; Janos K Lanyi
Distortions in the photocycle of bacteriorhodopsin at moderate dehydration.
Biophysical journal 1991;59(2):313-22.
1990: G Váró; Janos K Lanyi
Protonation and deprotonation of the M, N, and O intermediates during the bacteriorhodopsin photocycle.
Biochemistry 1990;29(29):6858-65.
1990: Janos K Lanyi; A Duschl; G Váro; László Zimányi
Anion binding to the chloride pump, halorhodopsin, and its implications for the transport mechanism.
FEBS letters 1990;265(1-2):1-6.
1990: B F Ni; M Chang; A Duschl; Janos K Lanyi; Richard Needleman
An efficient system for the synthesis of bacteriorhodopsin in Halobacterium halobium.
Gene 1990;90(1):169-72.
1990: G Váró; A Duschl; Janos K Lanyi
Interconversions of the M, N, and O intermediates in the bacteriorhodopsin photocycle.
Biochemistry 1990;29(15):3798-804.
1990: Janos K Lanyi
Halorhodopsin, a light-driven electrogenic chloride-transport system.
Physiological reviews 1990;70(2):319-30.
1990: G Váró; Janos K Lanyi
Pathways of the rise and decay of the M photointermediate(s) of bacteriorhodopsin.
Biochemistry 1990;29(9):2241-50.
1990: A Duschl; Janos K Lanyi; László Zimányi
Properties and photochemistry of a halorhodopsin from the haloalkalophile, Natronobacterium pharaonis.
The Journal of biological chemistry 1990;265(3):1261-7.
1990: Janos K Lanyi; A Duschl; G Wesley Hatfield; K May; D Oesterhelt
The primary structure of a halorhodopsin from Natronobacterium pharaonis. Structural, functional and evolutionary implications for bacterial rhodopsins and halorhodopsins.
The Journal of biological chemistry 1990;265(3):1253-60.
1989: G Váró; Janos K Lanyi
Photoreactions of bacteriorhodopsin at acid pH.
Biophysical journal 1989;56(6):1143-51.
1989: Brigitte Schobert; Janos K Lanyi
Hysteretic behavior of an ATPase from the archaebacterium, Halobacterium saccharovorum.
The Journal of biological chemistry 1989;264(22):12805-12.
1989: László Zimányi; Janos K Lanyi
Transient spectroscopy of bacterial rhodopsins with an optical multichannel analyzer. 2. Effects of anions on the halorhodopsin photocycle.
Biochemistry 1989;28(12):5172-8.
1989: László Zimányi; L Keszthelyi; Janos K Lanyi
Transient spectroscopy of bacterial rhodopsins with an optical multichannel analyzer. 1. Comparison of the photocycles of bacteriorhodopsin and halorhodopsin.
Biochemistry 1989;28(12):5165-72.
1989: László Zimányi; Janos K Lanyi
Low-temperature photoreactions of halorhodopsin. 2. Description of the photocycle and its intermediates.
Biochemistry 1989;28(4):1662-6.
1989: László Zimányi; Pál Ormos; Janos K Lanyi
Low-temperature photoreactions of halorhodopsin. 1. Detection of conformational substates of the chromoprotein.
Biochemistry 1989;28(4):1656-61.
1989: László Zimányi; Janos K Lanyi
Halorhodopsin: a light-driven active chloride transport system.
Annals of the New York Academy of Sciences 1989;574():11-9.
1988: A Duschl; M A McCloskey; Janos K Lanyi
Functional reconstitution of halorhodopsin. Properties of halorhodopsin-containing proteoliposomes.
The Journal of biological chemistry 1988;263(32):17016-22.
1988: Brigitte Schobert; Janos K Lanyi; D Oesterhelt
Structure and orientation of halorhodopsin in the membrane: a proteolytic fragmentation study.
The EMBO journal 1988;7(4):905-11.
1988: Janos K Lanyi; László Zimányi; K Nakanishi; F Derguini; M Okabe; B Honig
Chromophore/protein and chromophore/anion interactions in halorhodopsin.
Biophysical journal 1988;53(2):185-91.
1987: László Zimányi; Janos K Lanyi
Iso-halorhodopsin: a stable, 9-cis retinal containing photoproduct of halorhodopsin.
Biophysical journal 1987;52(6):1007-13.
1986: Igor Vodyanoy; Vitaly Vodyanoy; Janos K Lanyi
Current-voltage characteristics of planar lipid membranes with attached Halobacterium cell-envelope vesicles.
Biochimica et biophysica acta 1986;858(1):92-8.
1986: Janos K Lanyi; Vitaly Vodyanoy
Flash spectroscopic studies of the kinetics of the halorhodopsin photocycle.
Biochemistry 1986;25(6):1465-70.