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Tsvee Lapidot

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Tomer Itkin; Kerstin B Kaufmann; Shiri Gur-Cohen; Aya Ludin; Tsvee Lapidot
Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.
Kfir Lapid; Giulia Caglio; Gabriele D'Uva; Karin Golan; Tomer Itkin; Alexander Kalinkovich; Aya Ludin; Yossi Ovadya; Ziv Porat; Massimo Zollo; Tsvee Lapidot
GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.
Peter Valent; Stefan Wöhrer; Johannes Zuber; Michael Andreeff; Michel AROCK; Dominique Bonnet; Sabine Cerny-Reiterer; Christine Chomienne; Mhairi Copland; Ruggero De Maria; Harald Herrmann; Brian Huntly; Fumihiko Ishikawa; Hans E Johnsen; Tsvee Lapidot; Junia V Melo; Alexander Roesch; Jan Jacob Schuringa; Gerrit Jan Schuurhuis; Jean Soulier; Giorgio Stassi; Connie Eaves
Cancer stem cell definitions and terminology: the devil is in the details.

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All Publications

2013: Tomer Itkin; Kerstin B Kaufmann; Shiri Gur-Cohen; Aya Ludin; Tsvee Lapidot
Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.
Current opinion in hematology 2013;20(3):237-44.
2013: Kfir Lapid; Giulia Caglio; Gabriele D'Uva; Karin Golan; Tomer Itkin; Alexander Kalinkovich; Aya Ludin; Yossi Ovadya; Ziv Porat; Massimo Zollo; Tsvee Lapidot
GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.
The Journal of clinical investigation 2013;123(4):1705-17.
2012: Peter Valent; Stefan Wöhrer; Johannes Zuber; Michael Andreeff; Michel AROCK; Dominique Bonnet; Sabine Cerny-Reiterer; Christine Chomienne; Mhairi Copland; Ruggero De Maria; Harald Herrmann; Brian Huntly; Fumihiko Ishikawa; Hans E Johnsen; Tsvee Lapidot; Junia V Melo; Alexander Roesch; Jan Jacob Schuringa; Gerrit Jan Schuurhuis; Jean Soulier; Giorgio Stassi; Connie Eaves
Cancer stem cell definitions and terminology: the devil is in the details.
Nature reviews. Cancer 2012;12(11):767-75.
2012: Aya Ludin; Alexander Mildner; Ziv Porat; Amir Schajnovitz; Elias Shezen; Elena Voronov; Ron N Apte; David A Brenner; Gabriele D'Uva; Karin Golan; Shiri Gur-Cohen; Tomer Itkin; Steffen Jung; Alexander Kalinkovich; Orit Kollet; Tsvee Lapidot
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.
Nature immunology 2012;13(11):1072-82.
2012: meng zhao; John M Perry; Jason T Ross; Aparna Venkatraman; Chu-Xia Deng; Jeffrey S Haug; Xi C He; Mark J Hembree; Tomer Itkin; Tsvee Lapidot; Linheng Li
FGF signaling facilitates postinjury recovery of mouse hematopoietic system.
Blood 2012;120(9):1831-42.
2012: Tomer Itkin; Alexander Kalinkovich; Orit Kollet; Thorsten Berg; Jonathan Canaani; Douglas J Coffin; Grigori N Enikolopov; Ben Gradus; Shiri Gur-Cohen; Eran Hornstein; Aya Ludin; Yossi Ovadya; Wanda Piacibello; Amir Schajnovitz; Elias Shezen; Tsvee Lapidot
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.
Blood 2012;120(9):1843-55.
2012: Orit Kollet; Jonathan Canaani; Alexander Kalinkovich; Tsvee Lapidot
Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis.
Inflammation & allergy drug targets 2012;11(3):170-80.
2012: Maria Maryanovich; Hagit Niv; Galia Oberkovitz; Lidiya Vorobiyov; Yehudit Zaltsman; Ori Brenner; Steffen Jung; Tsvee Lapidot; Atan Gross
The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells.
Nature cell biology 2012;14(5):535-41.
2012: Karin Golan; Tomer Itkin; Alexander Kalinkovich; Chihwa Kim; Orit Kollet; Kfir Lapid; Aya Ludin; Andrew James Morris; Yossi Ovadya; Mariusz Z Ratajczak; Amir Schajnovitz; Shoham Shivtiel; Yaron Vagima; Shiri Cohen-Gur; Tsvee Lapidot
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.
Blood 2012;119(11):2478-88.
2012: Shiri Gur-Cohen; Kfir Lapid; Tsvee Lapidot
Quantifying hematopoietic stem and progenitor cell mobilization.
Methods in molecular biology (Clifton, N.J.) 2012;904():15-35.
2011: Shoham Shivtiel; Arnon Nagler; Abraham Avigdor; Polina Goichberg; Vyacheslav Kalchenko; Alexander Kalinkovich; Orit Kollet; Kfir Lapid; Tsvee Lapidot
CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice.
Experimental hematology 2011;39(12):1161-1170.e1.
2011: Karin Golan; Shiri Gur-Cohen; Polina Goichberg; Yaron Vagima; Tsvee Lapidot
MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration.
Journal of molecular medicine (Berlin, Germany) 2011;89(12):1167-74.
2011: Alexander Berchanski; Alexander Kalinkovich; Tsvee Lapidot; Aya Ludin; Aviva Lapidot
Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside-polyarginine conjugates.
The FEBS journal 2011;278(21):4150-65.
2011: Zohar Keren; Tsvee Lapidot; Ramit Mehr; Dana Averbuch; Karin Golan; Tomer Itkin; Gitit Shahaf; Simona Zisman-Rozen; Doron Melamed
Chronic B cell deficiency from birth prevents age-related alterations in the B lineage.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2140-7.
2011: Ayelet Dar; C E Dunbar; Paul S. Frenette; N Fujii; T Itkin; Alexander Kalinkovich; W-M Kao; Orit Kollet; Kfir Lapid; F Baleux; M Battista; H E Broxmeyer; E C Buss; N N Cohen; A Larochelle; A Ludin; R Margalit; S Oishi; A Schajnovitz; Melania Tesio; Tsvee Lapidot
Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.
Leukemia 2011;25(8):1286-96.
2011: Kira Orlovsky; Alexander Kalinkovich; Tanya Rozovskaia; Elias Shezen; Tomer Itkin; Hansjuerg Alder; Hatice Gulcin Ozer; Letizia Carramusa; Abraham Avigdor; Stefano Volinia; Arthur Buchberg; Alexander Mazo; Orit Kollet; Corey Largman; Carlo M Croce; Tatsuya Nakamura; Tsvee Lapidot; Eli Canaani
Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7956-61.
2011: Amir Schajnovitz; Tomer Itkin; Gabriele D'Uva; Alexander Kalinkovich; Karin Golan; Aya Ludin; Dror Cohen; Ziv Shulman; Abraham Avigdor; Arnon Nagler; Orit Kollet; Rony Seger; Tsvee Lapidot
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.
Nature immunology 2011;12(5):391-8.
2011: Zohar Keren; Shulamit Naor; Shahar Nussbaum; Karin Golan; Tomer Itkin; Yoshiteru Sasaki; Marc Schmidt-Supprian; Tsvee Lapidot; Doron Melamed
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.
Blood 2011;117(11):3104-12.
2011: Tomer Itkin; Tsvee Lapidot
SDF-1 keeps HSC quiescent at home.
Blood 2011;117(2):373-4.
2011: Melania Tesio; Karin Golan; Simona Corso; Silvia Giordano; Amir Schajnovitz; Yaron Vagima; Shoham Shivtiel; Alexander Kalinkovich; Luisa Caione; Loretta Gammaitoni; Elisa Laurenti; Eike C Buss; Elias Shezen; Tomer Itkin; Orit Kollet; Isabelle Petit; Andreas Trumpp; James Christensen; Massimo Aglietta; Wanda Piacibello; Tsvee Lapidot
Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.
Blood 2011;117(2):419-28.
2011: Jonathan Canaani; Orit Kollet; Tsvee Lapidot
Neural regulation of bone, marrow, and the microenvironment.
Frontiers in bioscience (Scholar edition) 2011;3():1021-31.
2010: Tsvee Lapidot; Orit Kollet
The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2010;2010():1-6.
2009: Alexander Kalinkovich; Asaf Spiegel; Shoham Shivtiel; Orit Kollet; Noela Jordaney; Wanda Piacibello; Tsvee Lapidot
Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system.
Brain, behavior, and immunity 2009;23(8):1059-65.
2009: Yaron Vagima; Abraham Avigdor; Polina Goichberg; Shoham Shivtiel; Melania Tesio; Alexander Kalinkovich; Karin Golan; Ayelet Dar; Orit Kollet; Isabelle Petit; Orly Perl; Eti Rosenthal; Igor Resnick; Izhar Hardan; Yechiel N Gellman; David Naor; Arnon Nagler; Tsvee Lapidot
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
The Journal of clinical investigation 2009;119(3):492-503.
2008: Asaf Spiegel; Alexander Kalinkovich; Shoham Shivtiel; Orit Kollet; Tsvee Lapidot
Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment.
Cell stem cell 2008;3(5):484-92.
2008: Alexandra Aicher; Orit Kollet; Christopher Heeschen; Stefan Liebner; Carmen Urbich; Christian Ihling; Alessia Orlandi; Tsvee Lapidot; Andreas M Zeiher; Stefanie Dimmeler
The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.
Circulation research 2008;103(8):796-803.
2008: Tanja Nicole Hartmann; Valentin Grabovsky; Ronit Pasvolsky; Ziv Shulman; Eike C Buss; Asaf Spiegel; Arnon Nagler; Tsvee Lapidot; Marcus Thelen; Ronen Alon
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.
Journal of leukocyte biology 2008;84(4):1130-40.
2008: Shoham Shivtiel; Orit Kollet; Kfir Lapid; Amir Schajnovitz; Polina Goichberg; Alexander Kalinkovich; Elias Shezen; Melania Tesio; Neta Netzer; Isabelle Petit; Amnon Sharir; Tsvee Lapidot
CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules.
The Journal of experimental medicine 2008;205(10):2381-95.
2008: Aviva Lapidot; Amnon Peled; Alexander Berchanski; Boaz Pal; Orit Kollet; Tsvee Lapidot; Gadi Borkow
NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity.
Biochimica et biophysica acta 2008;1780(6):914-20.
2008: Asaf Spiegel; Eyal Zcharia; Yaron Vagima; Tomer Itkin; Alexander Kalinkovich; Ayelet Dar; Orit Kollet; Neta Netzer; Karin Golan; Itay Shafat; Neta Ilan; Arnon Nagler; Israel Vlodavsky; Tsvee Lapidot
Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
Blood 2008;111(10):4934-43.
2007: Tsvee Lapidot; Polina Goichberg; Kfir Lapid; Abraham Avigdor; Orit Kollet
The endosteum region keeps human leukemic stem cells alive.
Cell stem cell 2007;1(5):483-4.
2007: Asaf Spiegel; Shoham Shivtiel; Alexander Kalinkovich; Aya Ludin; Neta Netzer; Polina Goichberg; Yaara Azaria; Igor B Resnick; Izhar Hardan; Herzl Ben-Hur; Arnon Nagler; Menachem Rubinstein; Tsvee Lapidot
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling.
Nature immunology 2007;8(10):1123-31.
2007: Orit Kollet; Ayelet Dar; Tsvee Lapidot
The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization.
Annual review of immunology 2007;25():51-69.
2006: Hilah Gal; Ninette Amariglio; Luba Trakhtenbrot; J Jacob-Hirsh; Ofer Margalit; Abraham Avigdor; Arnon Nagler; Sigal Tavor; Liat Ein-Dor; Tsvee Lapidot; Eytan Domany; Gideon Rechavi; David Givol
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells.
Leukemia 2006;20(12):2147-54.
2006: Alexander Kalinkovich; Sigal Tavor; Abraham Avigdor; Joy Kahn; Alexander Brill; Isabelle Petit; Polina Goichberg; Melania Tesio; Neta Netzer; Elizabeth Naparstek; Izhar Hardan; Arnon Nagler; Igor B Resnick; Alexander Tsimanis; Tsvee Lapidot
Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.
Cancer research 2006;66(22):11013-20.
2006: Neta Moskovits; Alexander Kalinkovich; Jair Bar; Tsvee Lapidot; Moshe Oren
p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts.
Cancer research 2006;66(22):10671-6.
2006: Vyacheslav Kalchenko; Shoham Shivtiel; Victoria Marcu (-Malina); Kfir Lapid; Sharon Haramati; Tsvee Lapidot; Alexander Brill; Alon Harmelin
Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing.
Journal of biomedical optics 2006;11(5):050507.
2006: Ayelet Dar; Orit Kollet; Tsvee Lapidot
Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice.
Experimental hematology 2006;34(8):967-75.
2006: Orit Kollet; Ayelet Dar; Shoham Shivtiel; Alexander Kalinkovich; Kfir Lapid; Yejezkel Sztainberg; Melania Tesio; Robert M Samstein; Polina Goichberg; Asaf Spiegel; Ari Elson; Tsvee Lapidot
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.
Nature medicine 2006;12(6):657-64.
2006: Marjorie Pick; Chava Perry; Tsvee Lapidot; Cinthya Guimaraes-Sternberg; Elizabeth Naparstek; varda deutsch; Hermona Soreq
Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis.
Blood 2006;107(8):3397-406.
2006: Polina Goichberg; Alexander Kalinkovich; Nataliya Borodovsky; Melania Tesio; Isabelle Petit; Arnon Nagler; Izhar Hardan; Tsvee Lapidot
cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors.
Blood 2006;107(3):870-9.
2006: Michele Cottler-Fox; Tsvee Lapidot
Mobilizing the older patient with myeloma.
Blood reviews 2006;20(1):43-50.
2005: John E Dick; Tsvee Lapidot
Biology of normal and acute myeloid leukemia stem cells.
International journal of hematology 2005;82(5):389-96.
2005: Ayelet Dar; Polina Goichberg; Vera Shinder; Alexander Kalinkovich; Orit Kollet; Neta Netzer; Raanan Margalit; Marion Zsak; Arnon Nagler; Izhar Hardan; Igor B Resnick; Antal Rot; Tsvee Lapidot
Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.
Nature immunology 2005;6(10):1038-46.
2005: Sigal Tavor; Isabelle Petit; Svetlana Porozov; Polina Goichberg; Abraham Avigdor; Sari Sagiv; Arnon Nagler; Elizabeth Naparstek; Tsvee Lapidot
Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice.
Blood 2005;106(6):2120-7.
2005: Tsvee Lapidot; Ayelet Dar; Orit Kollet
How do stem cells find their way home?
Blood 2005;106(6):1901-10.
2005: Alexandra Zanin-Zhorov; Guy Tal; Shoham Shivtiel; Michal Cohen; Tsvee Lapidot; Gabriel Nussbaum; Raanan Margalit; Irun R Cohen; Ofer Lider
Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):276-85.
2005: Angela Kortesidis; Andrew C W Zannettino; Sandra Isenmann; Songtao Shi; Tsvee Lapidot; Stan Gronthos
Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells.
Blood 2005;105(10):3793-801.
2005: Tamara Byk; Joy Kahn; Orit Kollet; Isabelle Petit; Sarit Samira; Shoham Shivtiel; Herzl Ben-Hur; Amnon Peled; Wanda Piacibello; Tsvee Lapidot
Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells.
Stem cells (Dayton, Ohio) 2005;23(4):561-74.
2005: Andrew C W Zannettino; Amanda N Farrugia; Angela Kortesidis; Jim Manavis; L Bik To; Sally K Martin; Peter Diamond; Hirokazu Tamamura; Tsvee Lapidot; Nobutaka Fujii; Stan Gronthos
Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients.
Cancer research 2005;65(5):1700-9.
2005: Isabelle Petit; Polina Goichberg; Asaf Spiegel; Amnon Peled; Chaya Brodie; Rony Seger; Arnon Nagler; Ronen Alon; Tsvee Lapidot
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells.
The Journal of clinical investigation 2005;115(1):168-76.
2004: Giuseppe Monaco; John W Belmont; Marina Konopleva; Michael Andreeff; Sigal Tavor; Isabelle Petit; Orit Kollet; Tsvee Lapidot
Correlation between CXCR4 and homing or engraftment of acute myelogenous leukemia.
Cancer research 2004;64(18):6832 author reply 6832-3.
2004: kang tae-bong; Tehila Ben-Moshe; Eugene E Varfolomeev; Yael Pewzner-Jung; Nir Yogev; Anna Jurewicz; Ari Waisman; Ori Brenner; Rebecca Haffner; Erika Elisabet Gustafsson; Parameswaran Ramakrishnan; Tsvee Lapidot; David Wallach
Caspase-8 serves both apoptotic and nonapoptotic roles.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2976-84.
2004: Iris Hecht; Rami Hershkoviz; Shoham Shivtiel; Tsvee Lapidot; Irun R Cohen; Ofer Lider; Liora Cahalon
Heparin-disaccharide affects T cells: inhibition of NF-kappaB activation, cell migration, and modulation of intracellular signaling.
Journal of leukocyte biology 2004;75(6):1139-46.
2004: Sigal Tavor; Isabelle Petit; Svetlana Porozov; Abraham Avigdor; Ayelet Dar; Leonor Leider-Trejo; Noga Shemtov; varda deutsch; Elizabeth Naparstek; Arnon Nagler; Tsvee Lapidot
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice.
Cancer research 2004;64(8):2817-24.
2004: Abraham Avigdor; Polina Goichberg; Shoham Shivtiel; Ayelet Dar; Amnon Peled; Sarit Samira; Orit Kollet; Rami Hershkoviz; Ronen Alon; Izhar Hardan; Herzl Ben-Hur; David Naor; Arnon Nagler; Tsvee Lapidot
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.
Blood 2004;103(8):2981-9.
2004: Joy Kahn; Tamara Byk; Lottie Jansson-Sjostrand; Isabelle Petit; Shoham Shivtiel; Arnon Nagler; Izhar Hardan; varda deutsch; Zulma Gazit; Dan Gazit; Stefan Karlsson; Tsvee Lapidot
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation.
Blood 2004;103(8):2942-9.
2004: Asaf Spiegel; Orit Kollet; Amnon Peled; Loya Abel; Arnon Nagler; Bella Bielorai; Gideon Rechavi; Josef Vormoor; Tsvee Lapidot
Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling.
Blood 2004;103(8):2900-7.
2004: Sarit Samira; Christophe Ferrand; Amnon Peled; Arnon Nagler; Yosef Tovbin; Herzl Ben-Hur; Naomi Taylor; Amiela Globerson; Tsvee Lapidot
Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice.
Stem cells (Dayton, Ohio) 2004;22(6):1085-100.
2003: Shoshana Peller; Jenny Frenkel; Tsvee Lapidot; Joy Kahn; Naomi Rahimi-Levene; Rivka Yona; Lior Nissim; Naomi Goldfinger; Dan J Sherman; Varda Rotter
The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts.
Oncogene 2003;22(30):4648-55.
2003: Orit Kollet; Shoham Shivtiel; Yuan-Qing Chen; Jenny Suriawinata; Swan N Thung; Mariana D Dabeva; Joy Kahn; Asaf Spiegel; Ayelet Dar; Sarit Samira; Polina Goichberg; Alexander Kalinkovich; Fernando Arenzana-Seisdedos; Arnon Nagler; Izhar Hardan; Michel Revel; David A Shafritz; Tsvee Lapidot
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.
The Journal of clinical investigation 2003;112(2):160-9.
2003: Loretta Gammaitoni; Stefania Bruno; Fiorella Sanavio; Monica Gunetti; Orit Kollet; Giuliana Cavalloni; Michele Falda; Franca Fagioli; Tsvee Lapidot; Massimo Aglietta; Wanda Piacibello
Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution.
Experimental hematology 2003;31(3):261-70.
2003: Michele Cottler-Fox; Tsvee Lapidot; Isabelle Petit; Orit Kollet; John F DiPersio; Dan Link; Steven Devine
Stem cell mobilization.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():419-37.
2002: Orit Kollet; Isabelle Petit; Joy Kahn; Sarit Samira; Ayelet Dar; Amnon Peled; varda deutsch; Monica Gunetti; Wanda Piacibello; Arnon Nagler; Tsvee Lapidot
Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation.
Blood 2002;100(8):2778-86.
2002: Tsvee Lapidot; Orit Kollet
The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice.
Leukemia 2002;16(10):1992-2003.
2002: Tsvee Lapidot; Isabelle Petit
Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells.
Experimental hematology 2002;30(9):973-81.
2002: Isabelle Petit; Martine Szyper-Kravitz; Arnon Nagler; Meir Lahav; Amnon Peled; Liliana Habler; Tanya Ponomaryov; Russell Taichman; Fernando Arenzana-Seisdedos; Nobutaka Fujii; Judith Sandbank; Dov Zipori; Tsvee Lapidot
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.
Nature immunology 2002;3(7):687-94.
2002: Amnon Peled; Izhar Hardan; Luba Trakhtenbrot; Eyal Gur; Michal Magid; Merav Darash-Yahana; Ninette Cohen; Valentin Grabovsky; Suzanna Franitza; Orit Kollet; Ofer Lider; Ronen Alon; Gideon Rechavi; Tsvee Lapidot
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.
Stem cells (Dayton, Ohio) 2002;20(3):259-66.
2002: Suzanna Franitza; Orit Kollet; Alexander Brill; Gayle G Vaday; Isabelle Petit; Tsvee Lapidot; Ronen Alon; Ofer Lider
TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.
European journal of immunology 2002;32(1):193-202.
2001: Tsvee Lapidot
Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions.
Annals of the New York Academy of Sciences 2001;938():83-95.
2001: Orit Kollet; Asaf Spiegel; Amnon Peled; Isabelle Petit; Tamara Byk; Rami Hershkoviz; Esther Guetta; G Barkai; Arnon Nagler; Tsvee Lapidot
Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.
Blood 2001;97(10):3283-91.
2001: Thomas Böldicke; M Tesar; C Griesel; M Rohde; H J Gröne; J Waltenberger; Orit Kollet; Tsvee Lapidot; Avner Yayon; Herbert A Weich
Anti-VEGFR-2 scFvs for cell isolation. Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/flk-1) on the surface of primary endothelial cells and preselected CD34+ cells from cord blood.
Stem cells (Dayton, Ohio) 2001;19(1):24-36.
2000: Tanya Ponomaryov; Amnon Peled; Isabelle Petit; Russell Taichman; Liliana Habler; Judith Sandbank; Fernando Arenzana-Seisdedos; A Magerus; Antonio Caruz; N Fujii; Arnon Nagler; Meir Lahav; Martine Szyper-Kravitz; Dov Zipori; Tsvee Lapidot
Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function.
The Journal of clinical investigation 2000;106(11):1331-9.
2000: Valentin Grabovsky; Sara W Feigelson; C Chen; DA Bleijs; Amnon Peled; Guy Cinamon; Françoise Baleux; Fernando Arenzana-Seisdedos; Tsvee Lapidot; Roy R Lobb; Ronen Alon
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.
The Journal of experimental medicine 2000;192(4):495-506.
2000: Orit Kollet; J G Moore; R Aviram; Herzl Ben-Hur; B L Liu; Arnon Nagler; Leonard D Shultz; M Feldman; Tsvee Lapidot
The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Experimental hematology 2000;28(6):726-36.
2000: Amnon Peled; Orit Kollet; Tanya Ponomaryov; Isabelle Petit; Suzanna Franitza; Valentin Grabovsky; M M Slav; Arnon Nagler; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
Blood 2000;95(11):3289-96.
2000: Orit Kollet; Amnon Peled; Tamara Byk; Herzl Ben-Hur; Dale Greiner; Leonard D Shultz; Tsvee Lapidot
beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Blood 2000;95(10):3102-5.
2000: Leonard D Shultz; P A Lang; Sherri W Christianson; Bruce Gott; Bonnie Lyons; S Umeda; Edward H Leiter; Ruth Hesselton; EJ Wagar; Jean Leif; Orit Kollet; Tsvee Lapidot; Dale L Greiner
NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2496-507.
1999: Amnon Peled; Valentin Grabovsky; Liliana Habler; Judith Sandbank; Fernando Arenzana-Seisdedos; Isabelle Petit; Herzl Ben-Hur; Tsvee Lapidot; Ronen Alon
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.
The Journal of clinical investigation 1999;104(9):1199-211.
1999: Orit Kollet; R Aviram; Judith Chebath; Herzl Ben-Hur; Arnon Nagler; Leonard D Shultz; Michel Revel; Tsvee Lapidot
The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Blood 1999;94(3):923-31.
1999: Wanda Piacibello; Fiorella Sanavio; A Severino; Alessandra Danè; Loretta Gammaitoni; Franca Fagioli; Eliana Perissinotto; Giuliana Cavalloni; Orit Kollet; Tsvee Lapidot; Massimo Aglietta
Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells.
Blood 1999;93(11):3736-49.
1999: Amnon Peled; Isabelle Petit; Orit Kollet; M Magid; Tanya Ponomaryov; Tamara Byk; Arnon Nagler; Herzl Ben-Hur; A Many; Leonard D Shultz; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Science (New York, N.Y.) 1999;283(5403):845-8.
1999: Amiela Globerson; Orit Kollet; L Abel; I Fajerman; A Ballin; A Nagler; S Slavin; H B Hur; Z Hagay; A Sharp; Tsvee Lapidot
Differential effects of CD4+ and CD8+ cells on lymphocyte development from human cord blood cells in murine fetal thymus explants.
Experimental hematology 1999;27(2):282-92.
1998: Eugene E Varfolomeev; Marcus Schuchmann; V Luria; N Chiannilkulchai; Jacques Beckmann; I L Mett; D Rebrikov; V M Brodianski; O C Kemper; Orit Kollet; Tsvee Lapidot; D Soffer; Tama Sobe; Karen B Avraham; Tanya M Goncharov; Helmut Holtmann; Peter Lonai; David Wallach
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Immunity 1998;9(2):267-76.
1997: Judith Chebath; D Fischer; A Kumar; J W Oh; O Kolett; Tsvee Lapidot; M Fischer; S Rose-John; Arnon Nagler; S Slavin; Michel Revel
Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities.
European cytokine network 1997;8(4):359-65.
1997: Amiram Ariel; Rami Hershkoviz; Liora Cahalon; D E Williams; S K Akiyama; Kenneth M Yamada; C Chen; Ronen Alon; Tsvee Lapidot; Ofer Lider
Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7.
European journal of immunology 1997;27(10):2562-70.
1997: Tsvee Lapidot; Y Fajerman; Orit Kollet
Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis.
Journal of molecular medicine (Berlin, Germany) 1997;75(9):664-73.
1997: Nechama Haran-Ghera; R Krautghamer; Tsvee Lapidot; Amnon Peled; Melissa G Dominguez; E Richard Stanley
Increased circulating colony-stimulating factor-1 (CSF-1) in SJL/J mice with radiation-induced acute myeloid leukemia (AML) is associated with autocrine regulation of AML cells by CSF-1.
Blood 1997;89(7):2537-45.
1996: A Larochelle; J Vormoor; Helmut Hanenberg; Jean C Y Wang; Mickie Bhatia; Tsvee Lapidot; T Moritz; Barbara Murdoch; X L Xiao; I Kato; David A Williams; John E Dick
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy.
Nature medicine 1996;2(12):1329-37.
1996: Tsvee Lapidot; T Grunberger; J Vormoor; Z Estrov; Orit Kollet; N Bunin; R Zaizov; D E Williams; Melvin H Freedman
Identification of human juvenile chronic myelogenous leukemia stem cells capable of initiating the disease in primary and secondary SCID mice.
Blood 1996;88(7):2655-64.
1996: C Sirard; Tsvee Lapidot; J Vormoor; Johanne Cashman; Monica Doedens; Barbara Murdoch; Nazir Jamal; Hans A Messner; L Addey; Mark D Minden; P Laraya; Armand Keating; Allen Eaves; Peter M Lansdorp; C J Eaves; John E Dick
Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis.
Blood 1996;87(4):1539-48.
1995: A Larochelle; J Vormoor; Tsvee Lapidot; GD Sher; T Furukawa; Q Li; L D Shultz; Nancy F Olivieri; G Stamatoyannopoulos; John E Dick
Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Human molecular genetics 1995;4(2):163-72.
1994: J Vormoor; Tsvee Lapidot; F Pflumio; G Risdon; B Patterson; H E Broxmeyer; John E Dick
Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice.
Blood 1994;83(9):2489-97.
1994: Tsvee Lapidot; C Sirard; J Vormoor; Barbara Murdoch; T Hoang; J Caceres-Cortes; Mark D Minden; B Paterson; M A Caligiuri; John E Dick
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.
Nature 1994;367(6464):645-8.
1994: J Vormoor; Tsvee Lapidot; F Pflumio; G Risdon; B Patterson; H E Broxmeyer; John E Dick
SCID mice as an in vivo model of human cord blood hematopoiesis.
Blood cells 1994;20(2-3):316-20; discussion 320-2.
1993: F Pflumio; Tsvee Lapidot; Barbara Murdoch; B Patterson; John E Dick
Engraftment of human lymphoid cells into newborn SCID mice leads to graft-versus-host disease.
International immunology 1993;5(12):1509-22.
1993: Y Faktorowich; Tsvee Lapidot; Ido Lubin; Yair Reisner
Enhancement of BM allografting from C57BL/6 'nude' mice into C3H/HeJ recipients by tolerized T cells from (C57BL/6-->C3H/HeJ) and (C3H/HeJ-->C57BL/6) chimeras.
Bone marrow transplantation 1993;12(1):15-20.
1993: Tsvee Lapidot; F Pflumio; John E Dick
Modeling human hematopoiesis in immunodeficient mice.
Laboratory animal science 1993;43(2):147-50.
1993: J Vormoor; Tsvee Lapidot; F Pflumio; G Risdon; B Patterson; H E Broxmeyer; John E Dick
High-level multilineage engraftment of human cord blood cells in SCID mice.
Journal of hematotherapy 1993;2(2):215-6.
1992: Tsvee Lapidot; Y Faktorowich; Ido Lubin; Yair Reisner
Enhancement of T-cell-depleted bone marrow allografts in the absence of graft-versus-host disease is mediated by CD8+ CD4- and not by CD8- CD4+ thymocytes.
Blood 1992;80(9):2406-11.
1992: Tsvee Lapidot; F Pflumio; Monica Doedens; Barbara Murdoch; D E Williams; John E Dick
Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice.
Science (New York, N.Y.) 1992;255(5048):1137-41.
1992: John E Dick; C Sirard; F Pflumio; Tsvee Lapidot
Murine models of normal and neoplastic human haematopoiesis.
Cancer surveys 1992;15():161-81.
1991: Suzanne Kamel-Reid; Michelle Letarte; Monica Doedens; A Greaves; Barbara Murdoch; T Grunberger; Tsvee Lapidot; P Thorner; Melvin H Freedman; R A Phillips
Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice.
Blood 1991;78(11):2973-81.
1991: John E Dick; Tsvee Lapidot; F Pflumio
Transplantation of normal and leukemic human bone marrow into immune-deficient mice: development of animal models for human hematopoiesis.
Immunological reviews 1991;124():25-43.
1991: John E Dick; F Pflumio; Tsvee Lapidot
Mouse models for human hematopoiesis.
Seminars in immunology 1991;3(6):367-78.
1991: Ido Lubin; Y Faktorowich; Tsvee Lapidot; Y Gan; Zelig Eshhar; E Gazit; Mia Levite; Yair Reisner
Engraftment and development of human T and B cells in mice after bone marrow transplantation.
Science (New York, N.Y.) 1991;252(5004):427-31.
1990: O Salomon; Tsvee Lapidot; Adelmo Terenzi; Ido Lubin; I Rabi; Yair Reisner
Induction of donor-type chimerism in murine recipients of bone marrow allografts by different radiation regimens currently used in treatment of leukemia patients.
Blood 1990;76(9):1872-8.
1990: Adelmo Terenzi; Ido Lubin; Tsvee Lapidot; O Salomon; Y Faktorowich; I Rabi; M F Martelli; Yair Reisner
Enhancement of T cell-depleted bone marrow allografts in mice by thiotepa.
Transplantation 1990;50(4):717-20.
1990: Tsvee Lapidot; Ido Lubin; Adelmo Terenzi; Y Faktorowich; P Erlich; Yair Reisner
Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4595-9.
1989: Tsvee Lapidot; Adelmo Terenzi; T S Singer; O Salomon; Yair Reisner
Enhancement by dimethyl myleran of donor type chimerism in murine recipients of bone marrow allografts.
Blood 1989;73(7):2025-32.
1988: Tsvee Lapidot; T S Singer; O Salomon; Adelmo Terenzi; E Schwartz; Yair Reisner
Booster irradiation to the spleen following total body irradiation. A new immunosuppressive approach for allogeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2619-24.
1988: Tsvee Lapidot; T S Singer; Yair Reisner
Transient engraftment of T cell-depleted allogeneic bone marrow in mice improves survival rate following lethal irradiation.
Bone marrow transplantation 1988;3(2):157-64.
1987: E Schwartz; Tsvee Lapidot; D Gozes; T S Singer; Yair Reisner
Abrogation of bone marrow allograft resistance in mice by increased total body irradiation correlates with eradication of host clonable T cells and alloreactive cytotoxic precursors.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(2):460-5.