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Ruth Lapushin

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William K Decker; John G Gribben; Matthew M Halpert; Michael J Keating; Ruth Lapushin; Sufang Li; Jeffrey J Molldrem; Simrit Parmar; Simon N Robinson; Nina Shah; Elizabeth J Shpall; Dongxia Xing; Hong Yang; William G Wierda
Generation of functional CLL-specific cord blood CTL using CD40-ligated CLL APC.
N Shah; Elizabeth J Shpall; S S Tung; William Decker; M Fernandez-Viña; Ruth Lapushin; Susan O'Brien; Simrit Parmar; Simon N Robinson; Dongxia Xing; Huiling Yang; William G Wierda
HLA homozygosity and haplotype bias among patients with chronic lymphocytic leukemia: implications for disease control by physiological immune surveillance.
Mariela Sivina; Elena Hartmann; Thomas J Kipps; Laura Rassenti; Diana Krupnik; Susan Lerner; Ruth Lapushin; Lianchun Xiao; Xuelin Huang; Lillian Werner; Donna Neuberg; Hagop Kantarjian; Susan O'Brien; William G Wierda; Michael J Keating; Andreas Rosenwald; Jan A Burger
CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia.

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All Publications

2012: William K Decker; John G Gribben; Matthew M Halpert; Michael J Keating; Ruth Lapushin; Sufang Li; Jeffrey J Molldrem; Simrit Parmar; Simon N Robinson; Nina Shah; Elizabeth J Shpall; Dongxia Xing; Hong Yang; William G Wierda
Generation of functional CLL-specific cord blood CTL using CD40-ligated CLL APC.
PloS one 2012;7(12):e51390.
2011: N Shah; Elizabeth J Shpall; S S Tung; William Decker; M Fernandez-Viña; Ruth Lapushin; Susan O'Brien; Simrit Parmar; Simon N Robinson; Dongxia Xing; Huiling Yang; William G Wierda
HLA homozygosity and haplotype bias among patients with chronic lymphocytic leukemia: implications for disease control by physiological immune surveillance.
Leukemia 2011;25(6):1036-9.
2011: Mariela Sivina; Elena Hartmann; Thomas J Kipps; Laura Rassenti; Diana Krupnik; Susan Lerner; Ruth Lapushin; Lianchun Xiao; Xuelin Huang; Lillian Werner; Donna Neuberg; Hagop Kantarjian; Susan O'Brien; William G Wierda; Michael J Keating; Andreas Rosenwald; Jan A Burger
CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia.
Blood 2011;117(5):1662-9.
2008: Alessandra Ferrajoli; Jan A Burger; Ruth Lapushin; Susan M O'Brien; Stefan Faderl; Mary L Browning; Michael J Keating
Pilot experience with continuous infusion alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia.
European journal of haematology 2008;80(4):296-8.
2004: Shuying Liu; Shuangxing Yu; Yutaka Hasegawa; Ruth Lapushin; Hong-Ji Xu; James R Woodgett; Gordon B Mills; Xianjun Fang
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
2004: Makiko Umezu-Goto; Janos L Tanyi; John Lahad; Shuying Liu; Shuangxing Yu; Ruth Lapushin; Yutaka Hasegawa; Yiling Lu; Rosanne Trost; Therese Bevers; Eric Jonasch; Kenneth Aldape; Jinsong Liu; Robyn D James; Colin G Ferguson; Yong Xu; Glenn D Prestwich; Gordon B Mills
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
2004: Xianjun Fang; Shuangxing Yu; Robert C Bast; Shuying Liu; Hong-Ji Xu; Shi-Xue Hu; Ruth Lapushin; Francois Claret; Bharat B Aggarwal; Yiling Lu; Gordon B Mills
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2003: Janos L Tanyi; Yutaka Hasegawa; Ruth Lapushin; Andrew J Morris; Judith K Wolf; Andrew Berchuck; Karen Lu; David I Smith; Kimberly R Kalli; Lynn C Hartmann; Karen McCune; David Fishman; Russell R Broaddus; Kwai Wa Cheng; E Neely Atkinson; Jose-Miguel Yamal; Robert C Bast; Edward Felix; Robert A Newman; Gordon B Mills
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3534-45.
2003: Ho-Young Lee; Harish Srinivas; Dianren Xia; Yiling Lu; Robert Superty; Ruth Lapushin; Candelaria Gomez-Manzano; Anna Maria Gal; Garrett L Walsh; Thomas Force; Kohjiro Ueki; Gordon B Mills; Jonathan M Kurie
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
The Journal of biological chemistry 2003;278(26):23630-8.
2003: Xiao-Feng Le; Francois Claret; Amy Lammayot; Ling Tian; Deepa Deshpande; Ruth Lapushin; Ana M Tari; Robert C Bast
The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition.
The Journal of biological chemistry 2003;278(26):23441-50.
2003: Janos L Tanyi; Andrew J Morris; Judith K Wolf; Xianjun Fang; Yutaka Hasegawa; Ruth Lapushin; Nelly Auersperg; Yury J Sigal; Robert A Newman; Edward Felix; E Neely Atkinson; Gordon B Mills
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
2002: Jia-Ju Bao; Xiao-Feng Le; Rui-Yu Wang; Jiuhong Yuan; Lin Wang; E Neely Atkinson; Ruth Lapushin; Michael Andreeff; Bingliang Fang; Yinhua Yu; Robert C Bast
Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway.
Cancer research 2002;62(24):7264-72.
2002: Janos L Tanyi; Ruth Lapushin; Astrid Eder; Nelly Auersperg; Fazal H Tabassam; Jack A Roth; Jian Gu; Bingliang Fang; Gordon B Mills; Judith Wolf
Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Gynecologic oncology 2002;85(3):451-8.
2002: Xianjun Fang; Michel Schummer; Muling Mao; Shuangxing Yu; Fazal H Tabassam; Ramona Swaby; Yutaka Hasegawa; Janos L Tanyi; Ruth Lapushin; Astrid Eder; Robert Jaffe; Jim Erickson; Gordon B Mills
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
2002: Gordon B Mills; Astrid Eder; Xianjun Fang; Yutaka Hasegawa; Muling Mao; Yiling Lu; Janos L Tanyi; Fazal H Tabassam; Jon R Wiener; Ruth Lapushin; Shiangxing Yu; Jeff A Parrott; Tim Compton; Walter Tribley; David Fishman; M Sharon Stack; Douglas Gaudette; Robert Jaffe; Tatsuro Furui; Junken Aoki; James R Erickson
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
2001: Bruce D Cuevas; Ying Lu; Muling Mao; Jinyi Zhang; Ruth Lapushin; Katherine A Siminovitch; Gordon B Mills
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(29):27455-61.
2001: Linus Ho; Ugur Aytac; L Clifton Stephens; Kei Ohnuma; Gordon B Mills; Kathryn S McKee; C Neumann; Ruth Lapushin; Fernando Cabanillas; James L Abbruzzese; Chikao Morimoto; Nam H Dang
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2031-40.
2000: Muling Mao; Xiang Fang; Ying Lu; Ruth Lapushin; Robert C Bast; Gordon B Mills
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
The Biochemical journal 2000;352 Pt 2():475-82.
2000: Xiang Fang; Shiangxing Yu; Ruth Lapushin; Ying Lu; Tatsuro Furui; L Z Penn; David Stokoe; James R Erickson; Robert C Bast; Gordon B Mills
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
The Biochemical journal 2000;352 Pt 1():135-43.
2000: N Sueoka; Ho-Young Lee; Garrett L Walsh; Bingliang Fang; Lin Ji; Jack A Roth; Ruth Lapushin; Waun Ki Hong; Pinchas Cohen; Jonathan M Kurie
Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment.
American journal of respiratory cell and molecular biology 2000;23(3):297-303.
2000: Xiang Fang; D Gaudette; Tatsuro Furui; Muling Mao; Veronica C Estrella; Astrid Eder; Terri B Pustilnik; T Sasagawa; Ruth Lapushin; Shiangxing Yu; R B Jaffe; Jon R Wiener; James R Erickson; Gordon B Mills
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Annals of the New York Academy of Sciences 2000;905():188-208.
1999: Tatsuro Furui; Ruth Lapushin; Muling Mao; H Khan; Steven Watt; M A Watt; Ying Lu; Xiang Fang; S Tsutsui; Zahid H Siddik; Robert C Bast; Gordon B Mills
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4308-18.
1999: Ying Lu; Y Z Lin; Ruth Lapushin; Bruce D Cuevas; Xiang Fang; S X Yu; Michael A Davies; H Khan; Tatsuro Furui; Muling Mao; R Zinner; M C Hung; PA Steck; Katherine A Siminovitch; Gordon B Mills
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
1998: Michael A Davies; Ying Lu; T Sano; Xiang Fang; P Tang; Ruth Lapushin; Dimpy Koul; Robert Bookstein; David Stokoe; W K Alfred Yung; Gordon B Mills; PA Steck
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.
1998: Ying Lu; Bruce D Cuevas; S Gibson; H Khan; Ruth Lapushin; J Imboden; Gordon B Mills
Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5404-12.
1998: Dimpy Koul; Ruth Lapushin; Hong-Ji Xu; Gordon B Mills; Jordan U Gutterman; D Choubey
p202 prevents apoptosis in murine AKR-2B fibroblasts.
Biochemical and biophysical research communications 1998;247(2):379-82.
1998: S Gibson; KE Truitt; Ying Lu; Ruth Lapushin; H Khan; J B Imboden; Gordon B Mills
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
The Biochemical journal 1998;330 ( Pt 3)():1123-8.
1996: Zeev Estrov; Moshe Talpaz; S Ku; David Harris; Ruth Lapushin; Charles Koller; C Hirsh-Ginsberg; Y Huh; G Yee; Razelle Kurzrock
Molecular and biologic characterization of a newly established Philadelphia-positive acute lymphoblastic leukemia cell line (Z-33) with an autocrine response to GM-CSF.
Leukemia 1996;10(9):1534-43.
1996: K Totpal; Saurabh Singh; Ruth Lapushin; Bharat B Aggarwal
Qualitative and quantitative differences in the cellular responses mediated through Fas antigen and tumor necrosis factor receptor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(3):259-67.
1995: Zeev Estrov; Roy A Black; P R Sleath; David Harris; Quin Van; Ruth Lapushin; Elihu H Estey; Moshe Talpaz
Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.
Blood 1995;86(12):4594-602.
1995: Zeev Estrov; B Samal; Ruth Lapushin; P Kellokumpu-Lehtinen; A A Sahin; Razelle Kurzrock; Moshe Talpaz; Bharat B Aggarwal
Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(10):905-13.
1995: K Totpal; Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells.
Blood 1995;85(12):3547-55.
1995: Bharat B Aggarwal; K Totpal; Ruth Lapushin; Madan M Chaturvedi; Olivia M Pereira-Smith; J R Smith
Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B.
Experimental cell research 1995;218(1):381-8.
1995: Bharat B Aggarwal; Saurabh Singh; Ruth Lapushin; K Totpal
Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor.
FEBS letters 1995;364(1):5-8.
1994: K Totpal; Ruth Lapushin; T Kohno; Bryant G Darnay; Bharat B Aggarwal
TNF and its receptor antibody agonist differ in mediation of cellular responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2248-57.
1994: Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
The Journal of biological chemistry 1994;269(20):14575-83.
1994: Ruth Lapushin; K Totpal; M Higuchi; Bharat B Aggarwal
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.
Journal of clinical immunology 1994;14(1):39-49.
1993: K Mujoo; Nicholas J Donato; Ruth Lapushin; Michael G Rosenblum; James L Murray
Tumor necrosis factor alpha and gamma-interferon enhancement of anti-epidermal growth factor receptor monoclonal antibody binding to human melanoma cells.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;13(3):166-74.
1991: K Totpal; Ruth Lapushin; Honnavara N Ananthaswamy; Bharat B Aggarwal
In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo.
Lymphokine and cytokine research 1991;10(5):359-67.
1988: D T Chu; J Lepe-Zuniga; W L Wong; Ruth Lapushin; G M Mavligit
Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2.
Journal of clinical & laboratory immunology 1988;26(4):183-7.