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William Large

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J Shi; M Ju; Sohag N Saleh; Anthony P Albert; William A Large
TRPC6 channels stimulated by angiotensin II are inhibited by TRPC1/C5 channel activity through a Ca2+- and PKC-dependent mechanism in native vascular myocytes.
Min Ju; Jian Shi; Sohag N Saleh; Anthony P Albert; William A Large
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.
Sohag N Saleh; Anthony P Albert; William A Large
Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes.

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All Publications

2010: J Shi; M Ju; Sohag N Saleh; Anthony P Albert; William A Large
TRPC6 channels stimulated by angiotensin II are inhibited by TRPC1/C5 channel activity through a Ca2+- and PKC-dependent mechanism in native vascular myocytes.
The Journal of physiology 2010;588(Pt 19):3671-82.
2010: Min Ju; Jian Shi; Sohag N Saleh; Anthony P Albert; William A Large
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.
The Journal of physiology 2010;588(Pt 9):1419-33.
2009: Sohag N Saleh; Anthony P Albert; William A Large
Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes.
The Journal of physiology 2009;587(Pt 22):5361-75.
2009: William A Large; Sohag N Saleh; Anthony P Albert
Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.
Cell calcium 2009;45(6):574-82.
2009: Sohag N Saleh; Anthony P Albert; William A Large
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.
The Journal of physiology 2009;587(Pt 3):531-40.
2009: Anthony P Albert; Sohag N Saleh; William A Large
Identification of canonical transient receptor potential (TRPC) channel proteins in native vascular smooth muscle cells.
Current medicinal chemistry 2009;16(9):1158-65.
2008: Anthony P Albert; Sohag N Saleh; William A Large
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes.
The Journal of physiology 2008;586(13):3087-95.
2008: Sohag N Saleh; Anthony P Albert; C M Peppiatt-Wildman; William A Large
Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.
The Journal of physiology 2008;586(10):2463-76.
2007: Anthony P Albert; Sohag N Saleh; C M Peppiatt-Wildman; William A Large
Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells.
The Journal of physiology 2007;583(Pt 1):25-36.
2007: C M Peppiatt-Wildman; Anthony P Albert; Sohag N Saleh; William A Large
Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes.
The Journal of physiology 2007;580(Pt.3):755-64.
2006: Sohag N Saleh; Anthony P Albert; C M Peppiatt; William A Large
Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.
The Journal of physiology 2006;577(Pt 2):479-95.
2006: Anthony P Albert; Min Liu; William A Large
Dual effect of calmodulin on store-operated Ca2+ -permeable cation channels in rabbit portal vein myocytes.
British journal of pharmacology 2006;148(7):1001-11.
2006: Anthony P Albert; Vladimir Pucovsky; S A Prestwich; William A Large
TRPC3 properties of a native constitutively active Ca2+-permeable cation channel in rabbit ear artery myocytes.
The Journal of physiology 2006;571(Pt 2):361-9.
2006: Anthony P Albert; William A Large
Signal transduction pathways and gating mechanisms of native TRP-like cation channels in vascular myocytes.
The Journal of physiology 2006;570(Pt 1):45-51.
2005: Anthony P Albert; Angela S Piper; William A Large
Role of phospholipase D and diacylglycerol in activating constitutive TRPC-like cation channels in rabbit ear artery myocytes.
The Journal of physiology 2005;566(Pt 3):769-80.
2005: M Liu; Anthony P Albert; William A Large
Facilitatory effect of Ins(1,4,5)P3 on store-operated Ca2+-permeable cation channels in rabbit portal vein myocytes.
The Journal of physiology 2005;566(Pt 1):161-71.
2005: M Liu; William A Large; Anthony P Albert
Stimulation of beta-adrenoceptors inhibits store-operated channel currents via a cAMP-dependent protein kinase mechanism in rabbit portal vein myocytes.
The Journal of physiology 2005;562(Pt 2):395-406.
2004: Anthony P Albert; William A Large
Inhibitory regulation of constitutive transient receptor potential-like cation channels in rabbit ear artery myocytes.
The Journal of physiology 2004;560(Pt 1):169-80.
2004: Angela S Piper; William A Large
Direct effect of Ca2+-calmodulin on cGMP-activated Ca2+-dependent Cl-channels in rat mesenteric artery myocytes.
The Journal of physiology 2004;559(Pt 2):449-57.
2004: Angela S Piper; William A Large
Single cGMP-activated Ca(+)-dependent Cl(-) channels in rat mesenteric artery smooth muscle cells.
The Journal of physiology 2004;555(Pt 2):397-408.
2003: Anthony P Albert; William A Large
Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes.
The Journal of physiology 2003;552(Pt 3):789-95.
2003: Anthony P Albert; Angela S Piper; William A Large
Properties of a constitutively active Ca2+-permeable non-selective cation channel in rabbit ear artery myocytes.
The Journal of physiology 2003;549(Pt 1):143-56.
2003: Anthony P Albert; William A Large
Store-operated Ca2+-permeable non-selective cation channels in smooth muscle cells.
Cell calcium 2003;33(5-6):345-56.
2003: Angela S Piper; William A Large
Multiple conductance states of single Ca2+-activated Cl- channels in rabbit pulmonary artery smooth muscle cells.
The Journal of physiology 2003;547(Pt 1):181-96.
2002: Anthony P Albert; William A Large
Activation of store-operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes.
The Journal of physiology 2002;544(Pt 1):113-25.
2002: D C Ellershaw; Iain A Greenwood; William A Large
Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes.
The Journal of physiology 2002;542(Pt 2):537-47.
2002: William A Large
Receptor-operated Ca2(+)-permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective.
Journal of cardiovascular electrophysiology 2002;13(5):493-501.
2002: Angela S Piper; Iain A Greenwood; William A Large
Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.
The Journal of physiology 2002;539(Pt 1):119-31.
2002: Anthony P Albert; William A Large
A Ca2+-permeable non-selective cation channel activated by depletion of internal Ca2+ stores in single rabbit portal vein myocytes.
The Journal of physiology 2002;538(Pt 3):717-28.
2002: Iain A Greenwood; Normand Leblanc; Dmitri V Gordienko; William A Large
Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents.
Pflügers Archiv : European journal of physiology 2002;443(3):473-82.
2001: Anthony P Albert; William A Large
The effect of external divalent cations on spontaneous non-selective cation channel currents in rabbit portal vein myocytes.
The Journal of physiology 2001;536(Pt 2):409-20.
2001: Anthony P Albert; William A Large
Comparison of spontaneous and noradrenaline-evoked non-selective cation channels in rabbit portal vein myocytes.
The Journal of physiology 2001;530(Pt 3):457-68.
2001: Anthony P Albert; AS Aromolaran; William A Large
Agents that increase tyrosine phosphorylation activate a non-selective cation current in single rabbit portal vein smooth muscle cells.
The Journal of physiology 2001;530(Pt 2):207-17.
2000: J E Graves; Iain A Greenwood; William A Large
Tonic regulation of vascular tone by nitric oxide and chloride ions in rat isolated small coronary arteries.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H2604-11.
2000: D C Ellershaw; Iain A Greenwood; William A Large
Dual modulation of swelling-activated chloride current by NO and NO donors in rabbit portal vein myocytes.
The Journal of physiology 2000;528 Pt 1():15-24.
2000: AS Aromolaran; Anthony P Albert; William A Large
Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes.
The Journal of physiology 2000;524 Pt 3():853-63.
1999: AS Aromolaran; William A Large
Comparison of the effects of divalent cations on the noradrenaline-evoked cation current in rabbit portal vein smooth muscle cells.
The Journal of physiology 1999;520 Pt 3():771-82.
1999: Iain A Greenwood; William A Large
Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions.
The Journal of physiology 1999;516 ( Pt 2)():365-76.
1998: Iain A Greenwood; William A Large
Properties of a Cl- current activated by cell swelling in rabbit portal vein vascular smooth muscle cells.
The American journal of physiology 1998;275(5 Pt 2):H1524-32.
1998: RM Helliwell; William A Large
Facilitatory effect of Ca2+ on the noradrenaline-evoked cation current in rabbit portal vein smooth muscle cells.
The Journal of physiology 1998;512 ( Pt 3)():731-41.
1997: Iain A Greenwood; RM Helliwell; William A Large
Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake.
The Journal of physiology 1997;505 ( Pt 1)():53-64.
1997: David N Criddle; R S de Moura; Iain A Greenwood; William A Large
Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat.
British journal of pharmacology 1997;120(5):813-8.
1997: RM Helliwell; William A Large
Alpha 1-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol.
The Journal of physiology 1997;499 ( Pt 2)():417-28.
1996: Iain A Greenwood; William A Large
Analysis of the time course of calcium-activated chloride "tail" currents in rabbit portal vein smooth muscle cells.
Pflügers Archiv : European journal of physiology 1996;432(6):970-9.
1996: William A Large; Q Wang
Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle.
The American journal of physiology 1996;271(2 Pt 1):C435-54.
1996: D N Criddle; Roberto Soares de Moura; Iain A Greenwood; William A Large
Effect of niflumic acid on noradrenaline-induced contractions of the rat aorta.
British journal of pharmacology 1996;118(4):1065-71.
1996: C Toma; Iain A Greenwood; R M Helliwell; William A Large
Activation of potassium currents by inhibitors of calcium-activated chloride conductance in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1996;118(3):513-20.
1996: R M Helliwell; William A Large
Dual effect of external Ca2+ on noradrenaline-activated cation current in rabbit portal vein smooth muscle cells.
The Journal of physiology 1996;492 ( Pt 1)():75-88.
1995: Iain A Greenwood; William A Large
Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1995;116(7):2939-48.
1995: R M Helliwell; William A Large
Effect of temperature on spontaneous Ca2+-activated Cl- currents in rabbit portal vein cells.
Pflügers Archiv : European journal of physiology 1995;431(1):28-31.
1995: Iain A Greenwood; R C Hogg; William A Large
Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca-activated currents in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1995;115(5):733-8.
1994: R C Hogg; Q Wang; William A Large
Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein.
British journal of pharmacology 1994;112(3):977-84.
1994: R C Hogg; Q Wang; William A Large
Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein.
British journal of pharmacology 1994;111(4):1333-41.
1994: R M Helliwell; Q Wang; R C Hogg; William A Large
Synergistic action of histamine and adenosine triphosphate on the response to noradrenaline in rabbit pulmonary artery smooth muscle cells.
Pflügers Archiv : European journal of physiology 1994;426(5):433-9.
1993: R C Hogg; Q Wang; R M Helliwell; William A Large
Properties of spontaneous inward currents in rabbit pulmonary artery smooth muscle cells.
Pflügers Archiv : European journal of physiology 1993;425(3-4):233-40.
1993: Q Wang; William A Large
Action of histamine on single smooth muscle cells dispersed from the rabbit pulmonary artery.
The Journal of physiology 1993;468():125-39.
1993: R C Hogg; Q Wang; William A Large
Time course of spontaneous calcium-activated chloride currents in smooth muscle cells from the rabbit portal vein.
The Journal of physiology 1993;464():15-31.
1993: Q Wang; R C Hogg; William A Large
A monovalent ion-selective cation current activated by noradrenaline in smooth muscle cells of rabbit ear artery.
Pflügers Archiv : European journal of physiology 1993;423(1-2):28-33.
1992: Q Wang; R C Hogg; William A Large
Properties of spontaneous inward currents recorded in smooth muscle cells isolated from the rabbit portal vein.
The Journal of physiology 1992;451():525-37.
1991: Q Wang; William A Large
Modulation of noradrenaline-induced membrane currents by papaverine in rabbit vascular smooth muscle cells.
The Journal of physiology 1991;439():501-12.
1991: William A Large
Three membrane-conductance mechanisms activated by noradrenaline in vascular smooth muscle.
Zeitschrift für Kardiologie 1991;80 Suppl 7():55-7.
1990: T Amédée; William A Large; Q Wang
Characteristics of chloride currents activated by noradrenaline in rabbit ear artery cells.
The Journal of physiology 1990;428():501-16.
1990: T Amédée; C D Benham; Thomas B Bolton; N G Byrne; William A Large
Potassium, chloride and non-selective cation conductances opened by noradrenaline in rabbit ear artery cells.
The Journal of physiology 1990;423():551-68.
1989: T Amédée; William A Large
Microelectrode study on the ionic mechanisms which contribute to the noradrenaline-induced depolarization in isolated cells of the rabbit portal vein.
British journal of pharmacology 1989;97(4):1331-7.
1988: N G Byrne; William A Large
Membrane ionic mechanisms activated by noradrenaline in cells isolated from the rabbit portal vein.
The Journal of physiology 1988;404():557-73.
1988: N G Byrne; William A Large
Mechanism of action of alpha-adrenoceptor activation in single cells freshly dissociated from the rabbit portal vein.
British journal of pharmacology 1988;94(2):475-82.
1987: N G Byrne; William A Large
Membrane mechanism associated with muscarinic receptor activation in single cells freshly dispersed from the rat anococcygeus muscle.
British journal of pharmacology 1987;92(2):371-9.
1987: N G Byrne; William A Large
Action of noradrenaline on single smooth muscle cells freshly dispersed from the rat anococcygeus muscle.
The Journal of physiology 1987;389():513-25.
1987: C D Benham; Thomas B Bolton; N G Byrne; William A Large
Action of externally applied adenosine triphosphate on single smooth muscle cells dispersed from rabbit ear artery.
The Journal of physiology 1987;387():473-88.
1987: N G Byrne; William A Large
The action of noradrenaline on single smooth muscle cells freshly dispersed from the guinea-pig pulmonary artery.
British journal of pharmacology 1987;91(1):89-94.
1986: N G Byrne; William A Large
The effect of alpha, beta-methylene ATP on the depolarization evoked by noradrenaline (gamma-adrenoceptor response) and ATP in the immature rat basilar artery.
British journal of pharmacology 1986;88(1):6-8.
1985: N G Byrne; William A Large
Evidence for two mechanisms of depolarization associated with alpha 1-adrenoceptor activation in the rat anococcygeus muscle.
British journal of pharmacology 1985;86(3):711-21.
1985: N G Byrne; G D Hirst; William A Large
Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development.
British journal of pharmacology 1985;86(1):217-27.
1984: N G Byrne; William A Large
Comparison of the biphasic excitatory junction potential with membrane responses to adenosine triphosphate and noradrenaline in the rat anococcygeus muscle.
British journal of pharmacology 1984;83(3):751-8.