Michael Lark

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Sui Yihong; Lee Jennifer H; DiMicco Michael A; Vanderploeg Eric J; Blake Simon M; Hung Han-Hwa; Plaas Anna H K; James Ian E; Song Xiao-Yu; Lark Michael W; Grodzinsky Alan J
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Kumar S; Dare L; Vasko-Moser J A; James I E; Blake S M; Rickard D J; Hwang S-M; Tomaszek T; Yamashita D S; Marquis R W; Oh H; Jeong J U; Veber D F; Gowen M; Lark M W; Stroup G
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
Struglics A; Larsson S; Pratta M A; Kumar S; Lark M W; Lohmander L S
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.

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2009: Sui Yihong; Lee Jennifer H; DiMicco Michael A; Vanderploeg Eric J; Blake Simon M; Hung Han-Hwa; Plaas Anna H K; James Ian E; Song Xiao-Yu; Lark Michael W; Grodzinsky Alan J
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Arthritis and rheumatism 2009;60(10):2985-96.
2007: Kumar S; Dare L; Vasko-Moser J A; James I E; Blake S M; Rickard D J; Hwang S-M; Tomaszek T; Yamashita D S; Marquis R W; Oh H; Jeong J U; Veber D F; Gowen M; Lark M W; Stroup G
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
Bone 2007;40(1):122-31.
2006: Struglics A; Larsson S; Pratta M A; Kumar S; Lark M W; Lohmander L S
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(2):101-13.
2005: Hankenson K D; James I E; Apone S; Stroup G B; Blake S M; Liang X; Lark M W; Bornstein P
Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(5):362-70.
2004: DiMicco Michael A; Patwari Parth; Siparsky Patrick N; Kumar Sanjay; Pratta Michael A; Lark Michael W; Kim Young-Jo; Grodzinsky Alan J
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
Arthritis and rheumatism 2004;50(3):840-8.
2004: Patwari P; Gaschen V; James I E; Berger E; Blake S M; Lark M W; Grodzinsky A J; Hunziker E B
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):245-52.
2004: Marquis Robert W; Ward Keith W; Roethke Theresa; Smith Brian R; Ru Yu; Yamashita Dennis S; Tomaszek Thaddeus A; Gorycki Peter D; Cheng H Y; James Ian E; Stroup George B; Lark Michael W; Gowen Maxine; Veber Daniel F
An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
Molecular pharmaceutics 2004;1(1):97-100.
2003: Patwari Parth; Cook Michael N; DiMicco Michael A; Blake Simon M; James Ian E; Kumar Sanjay; Cole Ada A; Lark Michael W; Grodzinsky Alan J
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Arthritis and rheumatism 2003;48(5):1292-301.
2003: Miller William H; Manley Peter J; Cousins Russell D; Erhard Karl F; Heerding Dirk A; Kwon Chet; Ross Stephen T; Samanen James M; Takata Dennis T; Uzinskas Irene N; Yuan Catherine C K; Haltiwanger R Curtis; Gress Catherine J; Lark Michael W; Hwang Shing Mei; James Ian E; Rieman David J; Willette Robert N; Yue Tian Li; Azzarano Leonard M; Salyers Kevin L; Smith Brian R; Ward Keith W; Johanson Kyung O; Huffman William F
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists.
Bioorganic & medicinal chemistry letters 2003;13(8):1483-6.
2002: Hoffman Sandra J; Vasko-Moser Janice; Miller William H; Lark Michael W; Gowen Maxine; Stroup George
Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2002;302(1):205-11.
2002: Lark Michael W; James Ian E
Novel bone antiresorptive approaches.
Current opinion in pharmacology 2002;2(3):330-7.
2002: Lark Michael W; Stroup G B; James I E; Dodds R A; Hwang S M; Blake S M; Lechowska B A; Hoffman S J; Smith B R; Kapadia R; Liang X; Erhard K; Ru Y; Dong X; Marquis R W; Veber D; Gowen M
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
Bone 2002;30(5):746-53.
2001: Connor J R; Kumar S; Sathe G; Mooney J; O'Brien S P; Mui P; Murdock P R; Gowen M; Lark M W
Clusterin expression in adult human normal and osteoarthritic articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):727-37.
2001: Kurz B; Jin M; Patwari P; Cheng D M; Lark M W; Grodzinsky A J
Biosynthetic response and mechanical properties of articular cartilage after injurious compression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(6):1140-6.
2001: Patwari P; Fay J; Cook M N; Badger A M; Kerin A J; Lark M W; Grodzinsky A J
In vitro models for investigation of the effects of acute mechanical injury on cartilage.
Clinical orthopaedics and related research 2001;(391 Suppl):S61-71.
2001: Kumar S; Connor J R; Dodds R A; Halsey W; Van Horn M; Mao J; Sathe G; Mui P; Agarwal P; Badger A M; Lee J C; Gowen M; Lark M W
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(7):641-53.
2001: Stroup G B; Lark M W; Veber D F; Bhattacharyya A; Blake S; Dare L C; Erhard K F; Hoffman S J; James I E; Marquis R W; Ru Y; Vasko-Moser J A; Smith B R; Tomaszek T; Gowen M
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1739-46.
2001: James I E; Marquis R W; Blake S M; Hwang S M; Gress C J; Ru Y; Zembryki D; Yamashita D S; McQueney M S; Tomaszek T A; Oh H J; Gowen M; Veber D F; Lark M W
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
The Journal of biological chemistry 2001;276(15):11507-11.
2001: Dodds R A; James I E; Rieman D; Ahern R; Hwang S M; Connor J R; Thompson S D; Veber D F; Drake F H; Holmes S; Lark M W; Gowen M
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(3):478-86.
2001: Lark M W; Stroup G B; Dodds R A; Kapadia R; Hoffman S J; Hwang S M; James I E; Lechowska B; Liang X; Rieman D J; Salyers K L; Ward K; Smith B R; Miller W H; Huffman W F; Gowen M
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):319-27.
2001: Badger A M; Blake S; Kapadia R; Sarkar S; Levin J; Swift B A; Hoffman S J; Stroup G B; Miller W H; Gowen M; Lark M W
Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis.
Arthritis and rheumatism 2001;44(1):128-37.
2000: James I E; Kumar S; Barnes M R; Gress C J; Hand A T; Dodds R A; Connor J R; Bradley B R; Campbell D A; Grabill S E; Williams K; Blake S M; Gowen M; Lark M W
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(6):452-63.
2000: Badger A M; Roshak A K; Cook M N; Newman-Tarr T M; Swift B A; Carlson K; Connor J R; Lee J C; Gowen M; Lark M W; Kumar S
Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(6):434-43.
2000: Jingushi S; Lohmander L S; Shinmei M; Hoerrner L A; Lark M W; Sugioka Y; Iwamoto Y
Markers of joint tissue turnover in joint fluids from hips with osteonecrosis of the femoral head.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(5):728-33.
2000: Loening A M; James I E; Levenston M E; Badger A M; Frank E H; Kurz B; Nuttall M E; Hung H H; Blake S M; Grodzinsky A J; Lark M W
Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.
Archives of biochemistry and biophysics 2000;381(2):205-12.
2000: Kapadia R D; Badger A M; Levin J M; Swift B; Bhattacharyya A; Dodds R A; Coatney R W; Lark M W
Meniscal ossification in spontaneous osteoarthritis in the guinea-pig.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(5):374-7.
2000: Nuttall M E; Nadeau D P; Fisher P W; Wang F; Keller P M; DeWolf W E; Goldring M B; Badger A M; Lee D; Levy M A; Gowen M; Lark M W
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):356-63.
2000: Wang F L; Connor J R; Dodds R A; James I E; Kumar S; Zou C; Lark M W; Gowen M; Nuttall M E
Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):161-9.
2000: Votta B J; White J R; Dodds R A; James I E; Connor J R; Lee-Rykaczewski E; Eichman C F; Kumar S; Lark M W; Gowen M
CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues.
Journal of cellular physiology 2000;183(2):196-207.
1999: Ragan P M; Badger A M; Cook M; Chin V I; Gowen M; Grodzinsky A J; Lark M W
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):836-42.
1999: Lark M W; Stroup G B; Hwang S M; James I E; Rieman D J; Drake F H; Bradbeer J N; Mathur A; Erhard K F; Newlander K A; Ross S T; Salyers K L; Smith B R; Miller W H; Huffman W F; Gowen M
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
The Journal of pharmacology and experimental therapeutics 1999;291(2):612-7.
1999: James I E; Lark M W; Zembryki D; Lee-Rykaczewski E V; Hwang S M; Tomaszek T A; Belfiore P; Gowen M
Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1562-9.
1999: Badger A M; Cook M N; Swift B A; Newman-Tarr T M; Gowen M; Lark M
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine.
The Journal of pharmacology and experimental therapeutics 1999;290(2):587-93.
1999: Miller W H; Bondinell W E; Cousins R D; Erhard K F; Jakas D R; Keenan R M; Ku T W; Newlander K A; Ross S T; Haltiwanger R C; Bradbeer J; Drake F H; Gowen M; Hoffman S J; Hwang S M; James I E; Lark M W; Lechowska B; Rieman D J; Stroup G B; Vasko-Moser J A; Zembryki D L; Azzarano L M; Adams P C; Huffman W F
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Bioorganic & medicinal chemistry letters 1999;9(13):1807-12.
1998: Kapadia R D; Stroup G B; Badger A M; Koller B; Levin J M; Coatney R W; Dodds R A; Liang X; Lark M W; Gowen M
Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis.
Technology and health care : official journal of the European Society for Engineering and Medicine 1998;6(5-6):361-72.
1998: Garcia A M; Lark M W; Trippel S B; Grodzinsky A J
Transport of tissue inhibitor of metalloproteinases-1 through cartilage: contributions of fluid flow and electrical migration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(6):734-42.
1998: Lohmander L S; Dahlberg L; Eyre D; Lark M; Thonar E J; Ryd L
Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(5):351-61.
1998: Badger A M; Cook M N; Lark M W; Newman-Tarr T M; Swift B A; Nelson A H; Barone F C; Kumar S
SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):467-73.
1997: Singer I I; Scott S; Kawka D W; Bayne E K; Weidner J R; Williams H R; Mumford R A; Lark M W; McDonnell J; Christen A J; Moore V L; Mudgett J S; Visco D M
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(6):407-18.
1997: Bonassar L J; Sandy J D; Lark M W; Plaas A H; Frank E H; Grodzinsky A J
Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.
Archives of biochemistry and biophysics 1997;344(2):404-12.
1997: Lark M W; Bayne E K; Flanagan J; Harper C F; Hoerrner L A; Hutchinson N I; Singer I I; Donatelli S A; Weidner J R; Williams H R; Mumford R A; Lohmander L S
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
The Journal of clinical investigation 1997;100(1):93-106.
1996: Bonassar L J; Stinn J L; Paguio C G; Frank E H; Moore V L; Lark M W; Sandy J D; Hollander A P; Poole A R; Grodzinsky A J
Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties.
Archives of biochemistry and biophysics 1996;333(2):359-67.
1996: Lohmander L S; Lark M W; Sandy J D
[Mechanisms of degradation of argecanes in osteoarthritic cartilage]
La Revue du praticien 1996;46(6 Spec No):S11-S14.
1995: Bonassar L J; Jeffries K A; Frank E H; Moore V L; Lark M W; Bayne E K; McDonnell J; Olszewski J; Hagmann W; Chapman K
In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor.
Arthritis and rheumatism 1995;38(11):1678-86.
1995: Lark M W; Bayne E K; Lohmander L S
Aggrecan degradation in osteoarthritis and rheumatoid arthritis.
Acta orthopaedica Scandinavica. Supplementum 1995;266():92-7.
1995: Lohmander L S; Roos H; Dahlberg L; Lark M W
The role of molecular markers to monitor disease, intervention and cartilage breakdown in osteoarthritis.
Acta orthopaedica Scandinavica. Supplementum 1995;266():84-7.
1995: Singer I I; Kawka D W; Bayne E K; Donatelli S A; Weidner J R; Williams H R; Ayala J M; Mumford R A; Lark M W; Glant T T
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
The Journal of clinical investigation 1995;95(5):2178-86.
1995: Lark M W; Williams H; Hoernner L A; Weidner J; Ayala J M; Harper C F; Christen A; Olszewski J; Konteatis Z; Webber R
Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
The Biochemical journal 1995;307 ( Pt 1)():245-52.
1995: Roos H; Dahlberg L; Hoerrner L A; Lark M W; Thonar E J; Shinmei M; Lindqvist U; Lohmander L S
Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1995;3(1):7-14.
1995: Lark M W; Gordy J T; Weidner J R; Ayala J; Kimura J H; Williams H R; Mumford R A; Flannery C R; Carlson S S; Iwata M
Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
The Journal of biological chemistry 1995;270(6):2550-6.
1995: Bonassar L J; Frank E H; Murray J C; Paguio C G; Moore V L; Lark M W; Sandy J D; Wu J J; Eyre D R; Grodzinsky A J
Changes in cartilage composition and physical properties due to stromelysin degradation.
Arthritis and rheumatism 1995;38(2):173-83.
1994: Dahlberg L; Fridén T; Roos H; Lark M W; Lohmander L S
A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture--synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1.
British journal of rheumatology 1994;33(12):1107-11.
1994: Dahlberg L; Roos H; Saxne T; Heinegård D; Lark M W; Hoerrner L A; Lohmander L S
Cartilage metabolism in the injured and uninjured knee of the same patient.
Annals of the rheumatic diseases 1994;53(12):823-7.
1994: Bonassar L J; Paguio C G; Frank E H; Jeffries K A; Moore V L; Lark M W; Caldwell C G; Hagmann W K; Grodzinsky A J
Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
Annals of the New York Academy of Sciences 1994;732():439-43.
1994: Lark M W; MacNaul K A; Donatelli S; McDonnell J; Hoerrner L A; Stevens K A; Saphos C A; Bayne E K; Hutchinson N I; Moore V L
Induction of increased levels of proteoglycan fragments in synovial fluid (SF) and increased levels of stromelysin in cartilage, synovium and SF by intraarticular injection of canine monocyte conditioned medium into dogs.
The Journal of rheumatology 1994;21(9):1716-24.
1994: Lohmander L S; Roos H; Dahlberg L; Hoerrner L A; Lark M W
Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(1):21-8.
1993: Wolfe G C; MacNaul K L; Buechel F F; McDonnell J; Hoerrner L A; Lark M W; Moore V L; Hutchinson N I
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Arthritis and rheumatism 1993;36(11):1540-7.
1993: Lohmander L S; Hoerrner L A; Dahlberg L; Roos H; Björnsson S; Lark M W
Stromelysin, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury.
The Journal of rheumatology 1993;20(8):1362-8.
1993: Lohmander L S; Hoerrner L A; Lark M W
Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
Arthritis and rheumatism 1993;36(2):181-9.
1993: McDonnell J; Lobner J M; Knight W B; Lark M W; Green B; Poe M; Moore V L
Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo.
Connective tissue research 1993;30(1):1-9.
1993: Saphos C A; Dey P; Lark M W; Moore V L
Sensitivity of monoclonal antibody, 5-D-4, for the detection of aggrecan, aggrecan fragments, and keratan sulfate.
Agents and actions 1993;39 Spec No():C154-6.
1992: Hutchinson N I; Lark M W; MacNaul K L; Harper C; Hoerrner L A; McDonnell J; Donatelli S; Moore V; Bayne E K
In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta.
Arthritis and rheumatism 1992;35(10):1227-33.
1992: McDonnell J; Hoerrner L A; Lark M W; Harper C; Dey T; Lobner J; Eiermann G; Kazazis D; Singer I I; Moore V L
Recombinant human interleukin-1 beta-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid.
Arthritis and rheumatism 1992;35(7):799-805.
1992: Lohmander L S; Lark M W; Dahlberg L; Walakovits L A; Roos H
Cartilage matrix metabolism in osteoarthritis: markers in synovial fluid, serum, and urine.
Clinical biochemistry 1992;25(3):167-74.
1992: Bayne E K; Hutchinson N I; Walakovits L A; Donatelli S; MacNaul K L; Harper C F; Cameron P; Moore V L; Lark M W
Production, purification and characterization of canine prostromelysin.
Matrix (Stuttgart, Germany) 1992;12(3):173-84.
1992: Flannery C R; Lark M W; Sandy J D
Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.
The Journal of biological chemistry 1992;267(2):1008-14.
1992: Walakovits L A; Moore V L; Bhardwaj N; Gallick G S; Lark M W
Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury.
Arthritis and rheumatism 1992;35(1):35-42.
1992: MacNaul K L; Chartrain N; Lark M; Tocci M J; Hutchinson N I
Differential effects of IL-1 and TNF alpha on the expression of stromelysin, collagenase and their natural inhibitor, TIMP, in rheumatoid human synovial fibroblasts.
Matrix (Stuttgart, Germany). Supplement 1992;1():198-9.
1991: Green B G; Weston H; Ashe B M; Doherty J; Finke P; Hagmann W; Lark M; Mao J; Maycock A; Moore V
PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.
Archives of biochemistry and biophysics 1991;286(1):284-92.
1990: MacNaul K L; Chartrain N; Lark M; Tocci M J; Hutchinson N I
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
The Journal of biological chemistry 1990;265(28):17238-45.
1990: Lark M W; Saphos C A; Walakovits L A; Moore V L
In vivo activity of human recombinant tissue inhibitor of metalloproteinases (TIMP). Activity against human stromelysin in vitro and in the rat pleural cavity.
Biochemical pharmacology 1990;39(12):2041-9.
1990: Lark M W; Walakovits L A; Shah T K; Vanmiddlesworth J; Cameron P M; Lin T Y
Production and purification of prostromelysin and procollagenase from IL-1 beta-stimulated human gingival fibroblasts.
Connective tissue research 1990;25(1):49-65.

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