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Michael Lark

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Yihong Sui; Jennifer H Lee; Michael A DiMicco; Eric J Vanderploeg; Simon M Blake; Han-Hwa Hung; Anna Plaas; Ian E James; Xiao-Yu Song; Michael W Lark; Alan J Grodzinsky
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Sanjay Kumar; LC Dare; Janice Vasko-Moser; Ian E James; Simon M Blake; D J Rickard; Shing-Mei Hwang; Thaddeus Tomaszek; Dennis S Yamashita; Robert W Marquis; H Oh; J U Jeong; Daniel F Veber; Maxine Gowen; Michael W Lark; George B Stroup
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
André Struglics; S Larsson; Michael A Pratta; Sanjay Kumar; Michael W Lark; L Stefan Lohmander
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.

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2009: Yihong Sui; Jennifer H Lee; Michael A DiMicco; Eric J Vanderploeg; Simon M Blake; Han-Hwa Hung; Anna Plaas; Ian E James; Xiao-Yu Song; Michael W Lark; Alan J Grodzinsky
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Arthritis and rheumatism 2009;60(10):2985-96.
2007: Sanjay Kumar; LC Dare; Janice Vasko-Moser; Ian E James; Simon M Blake; D J Rickard; Shing-Mei Hwang; Thaddeus Tomaszek; Dennis S Yamashita; Robert W Marquis; H Oh; J U Jeong; Daniel F Veber; Maxine Gowen; Michael W Lark; George B Stroup
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
Bone 2007;40(1):122-31.
2006: André Struglics; S Larsson; Michael A Pratta; Sanjay Kumar; Michael W Lark; L Stefan Lohmander
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(2):101-13.
2005: Kurt D Hankenson; Ian E James; S Apone; George B Stroup; Simon M Blake; X Liang; Michael W Lark; Paul Bornstein
Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(5):362-70.
2004: Michael A DiMicco; Parth Patwari; Patrick N Siparsky; Sanjay Kumar; Michael A Pratta; Michael W Lark; Young-Jo Kim; Alan J Grodzinsky
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
Arthritis and rheumatism 2004;50(3):840-8.
2004: Parth Patwari; Veronique Gaschen; Ian E James; E Berger; Simon M Blake; Michael W Lark; Alan J Grodzinsky; Ernst B Hunziker
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):245-52.
2004: Robert W Marquis; Keith W Ward; Theresa J Roethke; Brian R Smith; Yu Ru; Dennis S Yamashita; Thaddeus Tomaszek; Peter D Gorycki; H Y Cheng; Ian E James; George B Stroup; Michael W Lark; Maxine Gowen; Daniel F Veber
An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
Molecular pharmaceutics 2004;1(1):97-100.
2003: Parth Patwari; Michael N Cook; Michael A DiMicco; Simon M Blake; Ian E James; Sanjay Kumar; Ada A Cole; Michael W Lark; Alan J Grodzinsky
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Arthritis and rheumatism 2003;48(5):1292-301.
2003: William H Miller; Peter J Manley; Russell D Cousins; Karl F Erhard; Dirk A Heerding; Chet Kwon; Stephen T Ross; James Samanen; Dennis T Takata; Irene N Uzinskas; Catherine C K Yuan; R Curtis Haltiwanger; Catherine J Gress; Michael W Lark; Shing-Mei Hwang; Ian E James; David J Rieman; Robert N Willette; Tian-Li Yue; Leonard M Azzarano; Kevin L Salyers; Brian R Smith; Keith W Ward; Kyung O Johanson; William F Huffman
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists.
Bioorganic & medicinal chemistry letters 2003;13(8):1483-6.
2002: Sandra J Hoffman; Janice Vasko-Moser; William H Miller; Michael W Lark; Maxine Gowen; George B Stroup
Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2002;302(1):205-11.
2002: Michael W Lark; Ian E James
Novel bone antiresorptive approaches.
Current opinion in pharmacology 2002;2(3):330-7.
2002: Michael W Lark; George B Stroup; Ian E James; RA Dodds; Shing-Mei Hwang; Simon M Blake; BA Lechowska; Sandra J Hoffman; Brian R Smith; RD Kapadia; X Liang; Karl F Erhard; Yu Ru; X Dong; Robert W Marquis; Daniel F Veber; Maxine Gowen
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
Bone 2002;30(5):746-53.
2001: JR Connor; Sanjay Kumar; Ganesh Sathe; J Mooney; S P O'Brien; P Mui; Paul R Murdock; Maxine Gowen; Michael W Lark
Clusterin expression in adult human normal and osteoarthritic articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):727-37.
2001: Bodo Kurz; M Jin; Parth Patwari; D M Cheng; Michael W Lark; Alan J Grodzinsky
Biosynthetic response and mechanical properties of articular cartilage after injurious compression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(6):1140-6.
2001: Parth Patwari; Jakob Fay; Michael N Cook; AM Badger; Alex Kerin; Michael W Lark; Alan J Grodzinsky
In vitro models for investigation of the effects of acute mechanical injury on cartilage.
Clinical orthopaedics and related research 2001;(391 Suppl):S61-71.
2001: Sanjay Kumar; JR Connor; RA Dodds; WS Halsey; M Van Horn; J Mao; Ganesh Sathe; P Mui; Pankaj Agarwal; AM Badger; John Lee; Maxine Gowen; Michael W Lark
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(7):641-53.
2001: George B Stroup; Michael W Lark; Daniel F Veber; A Bhattacharyya; Simon Blake; LC Dare; Karl F Erhard; Sandra J Hoffman; Ian E James; Robert W Marquis; Yu Ru; Janice Vasko-Moser; Brian R Smith; Thaddeus Tomaszek; Maxine Gowen
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1739-46.
2001: Ian E James; Robert W Marquis; Simon M Blake; Shing-Mei Hwang; Catherine J Gress; Yu Ru; DL Zembryki; Dennis S Yamashita; Michael S McQueney; Thaddeus Tomaszek; HJ Oh; Maxine Gowen; Daniel F Veber; Michael W Lark
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
The Journal of biological chemistry 2001;276(15):11507-11.
2001: RA Dodds; Ian E James; David J Rieman; R Ahern; Shing-Mei Hwang; JR Connor; S D Thompson; Daniel F Veber; FH Drake; S Holmes; Michael W Lark; Maxine Gowen
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(3):478-86.
2001: Michael W Lark; George B Stroup; RA Dodds; RD Kapadia; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; BA Lechowska; X Liang; David J Rieman; Kevin L Salyers; K Ward; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):319-27.
2001: AM Badger; Simon Blake; RD Kapadia; S Sarkar; J Levin; Barbara A Swift; Sandra J Hoffman; George B Stroup; William H Miller; Maxine Gowen; Michael W Lark
Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis.
Arthritis and rheumatism 2001;44(1):128-37.
2000: Ian E James; Sanjay Kumar; M R Barnes; Catherine J Gress; A T Hand; RA Dodds; JR Connor; B R Bradley; D A Campbell; S E Grabill; K Williams; Simon M Blake; Maxine Gowen; Michael W Lark
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(6):452-63.
2000: AM Badger; Amy K Roshak; Michael N Cook; TM Newman-Tarr; Barbara A Swift; Karey Carlson; JR Connor; John Lee; Maxine Gowen; Michael W Lark; Sanjay Kumar
Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(6):434-43.
2000: AM Loening; Ian E James; ME Levenston; AM Badger; Eliot H Frank; Bodo Kurz; Mark E Nuttall; Han-Hwa Hung; Simon M Blake; Alan J Grodzinsky; Michael W Lark
Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.
Archives of biochemistry and biophysics 2000;381(2):205-12.
2000: Seiya Jingushi; L Stefan Lohmander; M Shinmei; L A Hoerrner; Michael W Lark; Yoichi Sugioka; Yukihide Iwamoto
Markers of joint tissue turnover in joint fluids from hips with osteonecrosis of the femoral head.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(5):728-33.
2000: RD Kapadia; AM Badger; J M Levin; Barbara A Swift; A Bhattacharyya; RA Dodds; Robert W Coatney; Michael W Lark
Meniscal ossification in spontaneous osteoarthritis in the guinea-pig.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(5):374-7.
2000: Mark E Nuttall; DP Nadeau; PW Fisher; F Wang; Paul M Keller; Walter E DeWolf; M B Goldring; AM Badger; Dennis Lee; MA Levy; Maxine Gowen; Michael W Lark
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):356-63.
2000: F L Wang; JR Connor; RA Dodds; Ian E James; Sanjay Kumar; C Zou; Michael W Lark; Maxine Gowen; Mark E Nuttall
Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):161-9.
2000: Bartholomew Votta; John White; RA Dodds; Ian E James; JR Connor; EV Lee-Rykaczewski; Christopher Eichman; Sanjay Kumar; Michael W Lark; Maxine Gowen
CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues.
Journal of cellular physiology 2000;183(2):196-207.
1999: PM Ragan; AM Badger; M Cook; V I Chin; Maxine Gowen; Alan J Grodzinsky; Michael W Lark
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):836-42.
1999: Michael W Lark; George B Stroup; Shing-Mei Hwang; Ian E James; David J Rieman; FH Drake; JN Bradbeer; A Mathur; Karl F Erhard; Kenneth A Newlander; Stephen T Ross; Kevin L Salyers; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
The Journal of pharmacology and experimental therapeutics 1999;291(2):612-7.
1999: Ian E James; Michael W Lark; DL Zembryki; EV Lee-Rykaczewski; Shing-Mei Hwang; Thaddeus Tomaszek; Pietro Belfiore; Maxine Gowen
Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1562-9.
1999: AM Badger; Michael N Cook; Barbara A Swift; TM Newman-Tarr; Maxine Gowen; Michael W Lark
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine.
The Journal of pharmacology and experimental therapeutics 1999;290(2):587-93.
1999: William H Miller; WE Bondinell; Russell D Cousins; Karl F Erhard; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Kenneth A Newlander; Stephen T Ross; R Curtis Haltiwanger; JN Bradbeer; FH Drake; Maxine Gowen; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; Michael W Lark; BA Lechowska; David J Rieman; George B Stroup; Janice Vasko-Moser; DL Zembryki; Leonard M Azzarano; P C Adams; William F Huffman
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Bioorganic & medicinal chemistry letters 1999;9(13):1807-12.
1998: RD Kapadia; George B Stroup; AM Badger; B Koller; J M Levin; Robert W Coatney; RA Dodds; X Liang; Michael W Lark; Maxine Gowen
Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis.
Technology and health care : official journal of the European Society for Engineering and Medicine 1998;6(5-6):361-72.
1998: A Minerva Garcia; Michael W Lark; Stephen B Trippel; Alan J Grodzinsky
Transport of tissue inhibitor of metalloproteinases-1 through cartilage: contributions of fluid flow and electrical migration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(6):734-42.
1998: L Stefan Lohmander; L Dahlberg; David R Eyre; Michael W Lark; Eugene Thonar; Leif Ryd
Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(5):351-61.
1998: AM Badger; Michael N Cook; Michael W Lark; TM Newman-Tarr; Barbara A Swift; Allen H Nelson; Frank C Barone; Sanjay Kumar
SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):467-73.
1997: Irwin I Singer; S Scott; Douglas W Kawka; Ellen K Bayne; JR Weidner; HR Williams; RA Mumford; Michael W Lark; J McDonnell; A J Christen; VL Moore; John S Mudgett; Denise visco
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(6):407-18.
1997: Lawrence J Bonassar; John D Sandy; Michael W Lark; Anna Plaas; Eliot H Frank; Alan J Grodzinsky
Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.
Archives of biochemistry and biophysics 1997;344(2):404-12.
1997: Michael W Lark; Ellen K Bayne; J Flanagan; C F Harper; L A Hoerrner; N I Hutchinson; Irwin I Singer; S A Donatelli; JR Weidner; HR Williams; RA Mumford; L Stefan Lohmander
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
The Journal of clinical investigation 1997;100(1):93-106.
1996: L J Bonassar; J L Stinn; C G Paguio; E H Frank; V L Moore; Michael W Lark; John D Sandy; A P Hollander; A R Poole; Alan J Grodzinsky
Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties.
Archives of biochemistry and biophysics 1996;333(2):359-67.
1996: L Stefan Lohmander; Michael W Lark; John D Sandy
[Mechanisms of degradation of argecanes in osteoarthritic cartilage].
La Revue du praticien 1996;46(6 Spec No):S11-S14.
1995: L J Bonassar; K A Jeffries; E H Frank; V L Moore; Michael W Lark; Ellen K Bayne; J McDonnell; J Olszewski; William K Hagmann; K Chapman
In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor.
Arthritis and rheumatism 1995;38(11):1678-86.
1995: Michael W Lark; Ellen K Bayne; L Stefan Lohmander
Aggrecan degradation in osteoarthritis and rheumatoid arthritis.
Acta orthopaedica Scandinavica. Supplementum 1995;266():92-7.
1995: L Stefan Lohmander; HP Roos; L Dahlberg; Michael W Lark
The role of molecular markers to monitor disease, intervention and cartilage breakdown in osteoarthritis.
Acta orthopaedica Scandinavica. Supplementum 1995;266():84-7.
1995: Irwin I Singer; Douglas W Kawka; Ellen K Bayne; S A Donatelli; J R Weidner; H R Williams; Julia Ayala; R A Mumford; Michael W Lark; T T Glant
VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
The Journal of clinical investigation 1995;95(5):2178-86.
1995: Michael W Lark; H Williams; L A Hoernner; J Weidner; Julia Ayala; C F Harper; A Christen; J Olszewski; Z Konteatis; R Webber
Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
The Biochemical journal 1995;307 ( Pt 1)():245-52.
1995: HP Roos; L Dahlberg; L A Hoerrner; Michael W Lark; Eugene Thonar; M Shinmei; U Lindqvist; L Stefan Lohmander
Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1995;3(1):7-14.
1995: Michael W Lark; J T Gordy; J R Weidner; J Ayala; J H Kimura; H R Williams; R A Mumford; C R Flannery; S S Carlson; M Iwata
Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
The Journal of biological chemistry 1995;270(6):2550-6.
1995: L J Bonassar; E H Frank; J C Murray; C G Paguio; V L Moore; Michael W Lark; John D Sandy; J J Wu; D R Eyre; Alan J Grodzinsky
Changes in cartilage composition and physical properties due to stromelysin degradation.
Arthritis and rheumatism 1995;38(2):173-83.
1994: L Dahlberg; Thomas Fridén; HP Roos; Michael W Lark; L Stefan Lohmander
A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture--synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1.
British journal of rheumatology 1994;33(12):1107-11.
1994: L Dahlberg; HP Roos; Tore Saxne; D Heinegård; Michael W Lark; L A Hoerrner; L Stefan Lohmander
Cartilage metabolism in the injured and uninjured knee of the same patient.
Annals of the rheumatic diseases 1994;53(12):823-7.
1994: L J Bonassar; C G Paguio; E H Frank; K A Jeffries; V L Moore; Michael W Lark; C G Caldwell; William K Hagmann; Alan J Grodzinsky
Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
Annals of the New York Academy of Sciences 1994;732():439-43.
1994: Michael W Lark; K A MacNaul; S Donatelli; J McDonnell; L A Hoerrner; K A Stevens; C A Saphos; Ellen K Bayne; N I Hutchinson; V L Moore
Induction of increased levels of proteoglycan fragments in synovial fluid (SF) and increased levels of stromelysin in cartilage, synovium and SF by intraarticular injection of canine monocyte conditioned medium into dogs.
The Journal of rheumatology 1994;21(9):1716-24.
1994: L Stefan Lohmander; HP Roos; L Dahlberg; L A Hoerrner; Michael W Lark
Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(1):21-8.
1993: G C Wolfe; K L MacNaul; F F Buechel; J McDonnell; L A Hoerrner; Michael W Lark; V L Moore; N I Hutchinson
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Arthritis and rheumatism 1993;36(11):1540-7.
1993: L Stefan Lohmander; L A Hoerrner; L Dahlberg; HP Roos; S Björnsson; Michael W Lark
Stromelysin, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury.
The Journal of rheumatology 1993;20(8):1362-8.
1993: L Stefan Lohmander; L A Hoerrner; Michael W Lark
Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
Arthritis and rheumatism 1993;36(2):181-9.
1993: J McDonnell; J M Lobner; W B Knight; Michael W Lark; B Green; M Poe; V L Moore
Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo.
Connective tissue research 1993;30(1):1-9.
1993: C A Saphos; P Dey; Michael W Lark; V L Moore
Sensitivity of monoclonal antibody, 5-D-4, for the detection of aggrecan, aggrecan fragments, and keratan sulfate.
Agents and actions 1993;39 Spec No():C154-6.
1992: N I Hutchinson; Michael W Lark; K L MacNaul; C Harper; L A Hoerrner; J McDonnell; S Donatelli; V Moore; Ellen K Bayne
In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta.
Arthritis and rheumatism 1992;35(10):1227-33.
1992: J McDonnell; L A Hoerrner; Michael W Lark; C Harper; T Dey; J Lobner; G Eiermann; D Kazazis; Irwin I Singer; V L Moore
Recombinant human interleukin-1 beta-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid.
Arthritis and rheumatism 1992;35(7):799-805.
1992: L Stefan Lohmander; Michael W Lark; L Dahlberg; L A Walakovits; HP Roos
Cartilage matrix metabolism in osteoarthritis: markers in synovial fluid, serum, and urine.
Clinical biochemistry 1992;25(3):167-74.
1992: Ellen K Bayne; N I Hutchinson; L A Walakovits; S Donatelli; K L MacNaul; C F Harper; P Cameron; V L Moore; Michael W Lark
Production, purification and characterization of canine prostromelysin.
Matrix (Stuttgart, Germany) 1992;12(3):173-84.
1992: C R Flannery; Michael W Lark; John D Sandy
Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.
The Journal of biological chemistry 1992;267(2):1008-14.
1992: K L MacNaul; N Chartrain; Michael W Lark; M J Tocci; N I Hutchinson
Differential effects of IL-1 and TNF alpha on the expression of stromelysin, collagenase and their natural inhibitor, TIMP, in rheumatoid human synovial fibroblasts.
Matrix (Stuttgart, Germany). Supplement 1992;1():198-9.
1992: L A Walakovits; V L Moore; N Bhardwaj; G S Gallick; Michael W Lark
Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury.
Arthritis and rheumatism 1992;35(1):35-42.
1991: Barbara G Green; H Weston; B M Ashe; J Doherty; P Finke; William K Hagmann; Michael W Lark; J Mao; A Maycock; V Moore
PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.
Archives of biochemistry and biophysics 1991;286(1):284-92.
1990: K L MacNaul; N Chartrain; Michael W Lark; M J Tocci; N I Hutchinson
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
The Journal of biological chemistry 1990;265(28):17238-45.
1990: Michael W Lark; C A Saphos; L A Walakovits; V L Moore
In vivo activity of human recombinant tissue inhibitor of metalloproteinases (TIMP). Activity against human stromelysin in vitro and in the rat pleural cavity.
Biochemical pharmacology 1990;39(12):2041-9.
1990: Michael W Lark; L A Walakovits; T K Shah; J Vanmiddlesworth; P M Cameron; T Y Lin
Production and purification of prostromelysin and procollagenase from IL-1 beta-stimulated human gingival fibroblasts.
Connective tissue research 1990;25(1):49-65.