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WJ LaRochelle

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Hisashi Takayama; Hitoshi Takagi; WJ LaRochelle; R P Kapur; Glenn Merlino
Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor.
Stefanie A Nelson; Kenneth Santora; WJ LaRochelle
Isolation and characterization of a novel PDGF-induced human gene.
Kenneth Santora; Stefanie A Nelson; K A Lewis; WJ LaRochelle
Avidin- or streptavidin-biotin as a highly sensitive method to stain total protein on membranes.

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All Publications

2001: Hisashi Takayama; Hitoshi Takagi; WJ LaRochelle; R P Kapur; Glenn Merlino
Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):297-305.
2000: Stefanie A Nelson; Kenneth Santora; WJ LaRochelle
Isolation and characterization of a novel PDGF-induced human gene.
Gene 2000;253(1):87-93.
2000: Kenneth Santora; Stefanie A Nelson; K A Lewis; WJ LaRochelle
Avidin- or streptavidin-biotin as a highly sensitive method to stain total protein on membranes.
Molecular biotechnology 2000;15(2):161-5.
2000: Stefanie A Nelson; J P Aris; Bharvin K R Patel; WJ LaRochelle
Multiple growth factor induction of a murine early response gene that complements a lethal defect in yeast ribosome biogenesis.
The Journal of biological chemistry 2000;275(18):13835-41.
2000: Toshiyuki Otsuka; John L Jakubczak; Wilfred D Vieira; Donald Bottaro; Diane Breckenridge; WJ LaRochelle; Glenn Merlino
Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis.
Molecular and cellular biology 2000;20(6):2055-65.
1999: Paul W Kriebel; Bharvin K R Patel; Stefanie A Nelson; M J Grusby; WJ LaRochelle
Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts.
Oncogene 1999;18(51):7294-302.
1999: WJ LaRochelle; Kazuyasu Sakaguchi; N Atabey; H G Cheon; Y Takagi; T Kinaia; Regina M Day; Toru Miki; Walter Burgess; Donald Bottaro
Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor.
Biochemistry 1999;38(6):1765-71.
1998: Toshiyuki Otsuka; Hisashi Takayama; Richard Sharp; G Celli; WJ LaRochelle; Donald Bottaro; N Ellmore; Wilfred D Vieira; J W Owens; Miriam R Anver; Glenn Merlino
c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype.
Cancer research 1998;58(22):5157-67.
1998: Bharvin K R Patel; CL Keck; R S O'Leary; Nicholas C Popescu; WJ LaRochelle
Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors.
Genomics 1998;52(2):192-200.
1998: G Celli; WJ LaRochelle; Susan Mackem; Richard Sharp; Glenn Merlino
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
The EMBO journal 1998;17(6):1642-55.
1998: John L Jakubczak; WJ LaRochelle; Glenn Merlino
NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo.
Molecular and cellular biology 1998;18(3):1275-83.
1998: Bharvin K R Patel; JH Pierce; WJ LaRochelle
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):172-7.
1997: Hisashi Takayama; WJ LaRochelle; S G Sabnis; Toshiyuki Otsuka; Glenn Merlino
Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor.
Laboratory investigation; a journal of technical methods and pathology 1997;77(2):131-8.
1997: J F Beeler; Bharvin K R Patel; Marcio Chedid; WJ LaRochelle
Cloning and characterization of the mouse homolog of the human A6 gene.
Gene 1997;193(1):31-7.
1997: X H Chen; Bharvin K R Patel; Ling Mei Wang; M Frankel; N Ellmore; R A Flavell; WJ LaRochelle; JH Pierce
Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
The Journal of biological chemistry 1997;272(10):6556-60.
1997: S G Diez de Medina; Dominique Chopin; Ahmed El Marjou; Annie Delouvée; WJ LaRochelle; A Hoznek; Claude C Abbou; Stuart A Aaronson; Jean Paul Thiery; François Radvanyi
Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas.
Oncogene 1997;14(3):323-30.
1997: Hisashi Takayama; WJ LaRochelle; Richard Sharp; Toshiyuki Otsuka; Paul W Kriebel; Miriam R Anver; Stuart A Aaronson; Glenn Merlino
Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):701-6.
1996: H Sakata; Hisashi Takayama; Richard Sharp; Jeffrey S Rubin; Glenn Merlino; WJ LaRochelle
Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(11):1513-23.
1996: Bharvin K R Patel; Ling Mei Wang; C C Lee; WG Taylor; JH Pierce; WJ LaRochelle
Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblasts.
The Journal of biological chemistry 1996;271(36):22175-82.
1995: D Mahadevan; J C Yu; J W Saldanha; N Thanki; Peter McPhie; Aykut Uren; WJ LaRochelle; MA Heidaran
Structural role of extracellular domain 1 of alpha-platelet-derived growth factor (PDGF) receptor for PDGF-AA and PDGF-BB binding.
The Journal of biological chemistry 1995;270(46):27595-600.
1995: Cinzia Marchese; M Chedid; O R Dirsch; Karl G Csaky; F Santanelli; C Latini; WJ LaRochelle; Maria Rosaria Torrisi; Stuart A Aaronson
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.
The Journal of experimental medicine 1995;182(5):1369-76.
1995: U Lichti; A B Scandurro; T Kartasova; Jeffrey S Rubin; WJ LaRochelle; Stuart H Yuspa
Hair follicle development and hair growth from defined cell populations grafted onto nude mice.
The Journal of investigative dermatology 1995;104(5 Suppl):43S-44S.
1995: WJ LaRochelle; O R Dirsch; P W Finch; H G Cheon; M May; Cinzia Marchese; JH Pierce; Stuart A Aaronson
Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera.
The Journal of cell biology 1995;129(2):357-66.
1995: MA Heidaran; D Mahadevan; WJ LaRochelle
Beta PDGFR-IgG chimera demonstrates that human beta PDGFR Ig-like domains 1 to 3 are sufficient for high affinity PDGF BB binding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):140-5.
1994: J C Yu; D Mahadevan; WJ LaRochelle; JH Pierce; MA Heidaran
Structural coincidence of alpha PDGFR epitopes binding to platelet-derived growth factor-AA and a potent neutralizing monoclonal antibody.
The Journal of biological chemistry 1994;269(14):10668-74.
1994: H G Cheon; WJ LaRochelle; Donald Bottaro; W H Burgess; Stuart A Aaronson
High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):989-93.
1994: J F Beeler; WJ LaRochelle; M Chedid; S R Tronick; Stuart A Aaronson
Prokaryotic expression cloning of a novel human tyrosine kinase.
Molecular and cellular biology 1994;14(2):982-8.
1993: M May; Stuart A Aaronson; WJ LaRochelle
Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.
Biochemistry 1993;32(43):11734-40.
1993: WJ LaRochelle; R A Jensen; MA Heidaran; M May-Siroff; Ling Mei Wang; Stuart A Aaronson; JH Pierce
Inhibition of platelet-derived growth factor autocrine growth stimulation by a monoclonal antibody to the human alpha platelet-derived growth factor receptor.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(7):547-53.
1993: MA Heidaran; J F Beeler; J C Yu; T Ishibashi; WJ LaRochelle; JH Pierce; Stuart A Aaronson
Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.
The Journal of biological chemistry 1993;268(13):9287-95.
1992: R A Jensen; J F Beeler; MA Heidaran; WJ LaRochelle
Characterization of baculovirus-expressed human alpha and beta platelet-derived growth factor receptors.
Biochemistry 1992;31(44):10887-92.
1992: WJ LaRochelle; JH Pierce; M May-Siroff; N Giese; Stuart A Aaronson
Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
The Journal of biological chemistry 1992;267(24):17074-7.
1991: WJ LaRochelle; M May-Siroff; K C Robbins; Stuart A Aaronson
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.
Genes & development 1991;5(7):1191-9.
1990: N Giese; WJ LaRochelle; M May-Siroff; K C Robbins; Stuart A Aaronson
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
Molecular and cellular biology 1990;10(10):5496-501.
1990: WJ LaRochelle; N Giese; M May-Siroff; K C Robbins; Stuart A Aaronson
Molecular localization of the transforming and secretory properties of PDGF A and PDGF B.
Science (New York, N.Y.) 1990;248(4962):1541-4.
1990: WJ LaRochelle; N Giese; M May-Siroff; K C Robbins; Stuart A Aaronson
Chimeric molecules map and dissociate the potent transforming and secretory properties of PDGF A and PDGF B.
Journal of cell science. Supplement 1990;13():31-42.
1989: T Matsui; JH Pierce; T P Fleming; J S Greenberger; WJ LaRochelle; M Ruggiero; Stuart A Aaronson
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8314-8.
1989: WJ LaRochelle; K C Robbins; Stuart A Aaronson
Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activity.
Molecular and cellular biology 1989;9(8):3538-42.
1989: N Giese; M May-Siroff; WJ LaRochelle; K van Wyke Coelingh; Stuart A Aaronson
Expression and purification of biologically active v-sis/platelet-derived growth factor B protein by using a baculovirus vector system.
Journal of virology 1989;63(7):3080-6.