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Christian Larsen

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D J Lo; A K Mehta; Mingqing Song; Elizabeth Strobert; N A Turgeon; T A Weaver; D J Anderson; A B Farris; J Jenkins; Christian P Larsen; F Leopardi; Allan D Kirk
Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.
M C Lowe; Elizabeth Strobert; P W Thompson; A P Turner; I R Badell; Christian P Larsen; F V Leopardi; Allan D Kirk
Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
M Lowe; B Martin; A A Price; H S Abdulkerim; Andrew B Adams; I R Badell; Neal N Iwakoshi; Allan D Kirk; Christian P Larsen; F Leopardi; Elizabeth Strobert; P Thompson; R Wang; K A Reimann
A novel monoclonal antibody to CD40 prolongs islet allograft survival.

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2013: D J Lo; A K Mehta; Mingqing Song; Elizabeth Strobert; N A Turgeon; T A Weaver; D J Anderson; A B Farris; J Jenkins; Christian P Larsen; F Leopardi; Allan D Kirk
Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;13(2):320-8.
2013: M C Lowe; Elizabeth Strobert; P W Thompson; A P Turner; I R Badell; Christian P Larsen; F V Leopardi; Allan D Kirk
Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;13(2):312-9.
2012: M Lowe; B Martin; A A Price; H S Abdulkerim; Andrew B Adams; I R Badell; Neal N Iwakoshi; Allan D Kirk; Christian P Larsen; F Leopardi; Elizabeth Strobert; P Thompson; R Wang; K A Reimann
A novel monoclonal antibody to CD40 prolongs islet allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(8):2079-87.
2012: S K Ramakrishnan; S Sen; Karnail Singh; Mingqing Song; L Stempora; Elizabeth Strobert; T Deane; A B Farris; Kelly Hamby; Allan D Kirk; Christian P Larsen; F Leopardi; A Page; A Polnett; Leslie S Kean
Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1755-64.
2012: P Thompson; A Turner; Richard N Pierson III; J Avila; Agnes M Azimzadeh; I R Badell; J Cano; X Cheng; B Johnson; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; J Robertson; Mingqing Song; Elizabeth Strobert; Allan D Kirk
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1765-75.
2012: I R Badell; J A Cano; Kenneth Cardona; Mandy L Ford; Allan D Kirk; F V Leopardi; Thomas C Pearson; M C Russell; V O Shaffer; Mingqing Song; Elizabeth Strobert; A P Turner; J G Avila; Christian P Larsen
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1918-23.
2012: K Singh; L Stempora; Bruce R Blazar; Allan D Kirk; N Kozyr; Christian P Larsen; Leslie S Kean
Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(6):1441-57.
2012: Nicole A Turgeon; Sudha Tata; S Scott Davis; Allan D Kirk; Christian P Larsen; Edward Lin; Max Mondestin; Thomas C Pearson; Sebastian Perez; John F Sweeney
The impact of renal function on outcomes of bariatric surgery.
Journal of the American Society of Nephrology : JASN 2012;23(5):885-94.
2012: Leslie S Kean; Bruce R Blazar; K Singh; Christian P Larsen
Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(4):812-9.
2012: Z P Johnson; S Agravat; S F Ahmad; R D Eady; James ELSE; S M Lank; Christian P Larsen; T Morris; D H O'Connor; M C T Penedo; R W Wiseman; Leslie S Kean
Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.
Immunogenetics 2012;64(4):329-36.
2012: D C Neujahr; S D Perez; A Pickens; M Song; O Ulukpo; F Fernandez; Seth D Force; Christian P Larsen; E Clinton Lawrence; A Mohammed; Allan D Kirk
Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(2):438-46.
2012: Flavio Vincenti; J Xing; M Agarwal; J Alberu; B Bresnahan; V D Garcia; M B Harler; J Kothari; P Lang; Christian P Larsen; P Massari; G Mondragon-Ramirez; R Reyes-Acevedo; K Rice; Lionel Rostaing; S Steinberg; E Mancilla Urrea; B Charpentier
Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):210-7.
2012: W H Kitchens; Christian P Larsen; M Song; Maylene E Wagener; D Haridas; Allan D Kirk; Mandy L Ford
Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):69-80.
2012: A Page; A A Price; K A Reimann; M Russell; S Sen; K Singh; S Srinivasan; L Stempora; Elizabeth Strobert; T Deane; Kelly Hamby; Allan D Kirk; Christian P Larsen; F Leopardi; Leslie S Kean
CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):115-25.
2012: I R Badell; J A Cano; Mandy L Ford; N N Iwakoshi; Allan D Kirk; F V Leopardi; K A Reimann; J M Robertson; M C Russell; Elizabeth Strobert; P W Thompson; A P Turner; J G Avila; Christian P Larsen
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):126-35.
2011: Ivana R Ferrer; Christian P Larsen; Maylene E Wagener; Allan D Kirk; Minqing Song; Mandy L Ford
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(51):20701-6.
2011: A Mohammed; S D Force; F Fernandez; Allan D Kirk; K C Easley; O Ulukpo; A Pickens; Christian P Larsen; A A Gal; E C Lawrence; D C Neujahr
Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.
Transplantation proceedings 2011;43(10):3892-8.
2011: P Thompson; J Avila; I R Badell; J Cano; N Iwakoshi; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; R Ruhil; M Song; E Strobert; Allan D Kirk
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(12):2593-602.
2011: Natalie M Reisman; Maylene E Wagener; Tamara L Floyd; Allan D Kirk; Christian P Larsen; Mandy L Ford
LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
Blood 2011;118(22):5851-61.
2011: Simon Mwangi; Nikrad Shahnavaz; Shanthi V Sitaraman; Jose Avila; Jose Cano; Veerappa K Chetty; Irene Joseph; Christian P Larsen; Yousef Usta; Shanthi Srinivasan
Glial cell line-derived neurotrophic factor enhances human islet posttransplantation survival.
Transplantation 2011;92(7):745-51.
2011: Mandy L Ford; Christian P Larsen
Transplantation tolerance: memories that haunt us.
Science translational medicine 2011;3(86):86ps22.
2011: Allan D Kirk; Stuart J Knechtle; Christian P Larsen; Kenneth A Newell; Thomas C Pearson
Miles to go….
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(6):1119-20.
2011: Yves Vanrenterghem; Alan Block; Barbara Bresnahan; Josep Campistol; Tao Duan; Antoine Durrbach; Alan Glicklich; Josep Grinyó; Sheila Gujrathi; Philippe Lang; Christian P Larsen; Eduardo Mancilla-Urrea; Hans-Hellmut Neumayer; José Medina Pestana; Flavio Vincenti
Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies).
Transplantation 2011;91(9):976-83.
2011: P Thompson; K Cardona; M Russell; I R Badell; V Shaffer; Gregory S Korbutt; Gina R Rayat; J Cano; M Song; W Jiang; E Strobert; Ray V Rajotte; Thomas C Pearson; Allan D Kirk; Christian P Larsen
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(5):947-57.
2011: David C Neujahr; Christian P Larsen
Regulatory T cells in lung transplantation--an emerging concept.
Seminars in immunopathology 2011;33(2):117-27.
2011: William H Kitchens; Christian P Larsen; Mandy L Ford
Integrin antagonists for transplant immunosuppression: panacea or peril?
Immunotherapy 2011;3(3):305-7.
2011: A P Turner; V O Shaffer; Koichi Araki; C Martens; P L Turner; Shivaprakash Gangappa; Mandy L Ford; Rafi Ahmed; Allan D Kirk; Christian P Larsen
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(3):613-8.
2011: Christian P Larsen; Eric T. Elwood; Diane Z Alexander; Shannon C Ritchie; Rose Hendrix; Carol Tucker-Burden; Hong Rae Cho; Alejandro Aruffo; Diane Hollenbaugh; Peter S Linsley; Kevin J Winn; Thomas C Pearson
Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2693-7.
2011: Tamara L Floyd; Brent Howard Koehn; William H Kitchens; Jennifer M Robertson; Jennifer A Cheeseman; Linda Stempora; Christian P Larsen; Mandy L Ford
Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2033-41.
2011: Mandy L Ford; Linda L Stempora; Christian P Larsen
CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha.
Transplant immunology 2011;24(2):94-9.
2011: D J Lo; T A Weaver; L Stempora; A K Mehta; Mandy L Ford; Christian P Larsen; Allan D Kirk
Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(1):22-33.
2010: Josep Grinyó; Bernard Charpentier; José Medina Pestana; Yves Vanrenterghem; Flavio Vincenti; Rafael Reyes-Acevedo; Anne Marie Apanovitch; Sheila Gujrathi; Mamta Agarwal; Dolca Thomas; Christian P Larsen
An integrated safety profile analysis of belatacept in kidney transplant recipients.
Transplantation 2010;90(12):1521-7.
2010: Christian P Larsen; Josep Grinyó; José Medina-Pestana; Yves Vanrenterghem; Flavio Vincenti; Barbara Breshahan; Josep M Campistol; Sander Florman; Maria del Carmen Rial; Nassim Kamar; Alan Block; Gregory Di Russo; Chen-Sheng Lin; Pushkal Garg; Bernard Charpentier
Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies.
Transplantation 2010;90(12):1528-35.
2010: Weston P Miller; Swetha Srinivasan; Angela Panoskaltsis-Mortari; Karnail Singh; Sharon Sen; Kelly Hamby; Taylor Deane; Linda Stempora; Jonathan Beus; Alexa Turner; Caleb Wheeler; Daniel C Anderson; Prachi Sharma; Anapatricia Garcia; Elizabeth Strobert; Eric Elder; Ian Crocker; Timothy Crenshaw; M Cecilia T Penedo; Thea Ward; Mingqing Song; John Horan; Christian P Larsen; Bruce R Blazar; Leslie S Kean
GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression.
Blood 2010;116(24):5403-18.
2010: Idelberto R Badell; Maria C Russell; Peter W Thompson; Alexandra P Turner; Tim A Weaver; Jennifer M Robertson; Jose G Avila; Jose A Cano; Brandi E Johnson; Mingqing Song; Frank V Leopardi; Sarah Swygert; Elizabeth A Strobert; Mandy L Ford; Allan D Kirk; Christian P Larsen
LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
The Journal of clinical investigation 2010;120(12):4520-31.
2010: Christian P Larsen; A Page; K H Linzie; M Russell; T Deane; L Stempora; Elizabeth Strobert; M C T Penedo; T Ward; R Wiseman; D O'Connor; W Miller; S Sen; K Singh; Leslie S Kean
An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(11):2396-409.
2010: Koichi Araki; Shivaprakash Gangappa; Dirck L Dillehay; Barry T Rouse; Christian P Larsen; Rafi Ahmed
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.
The Journal of experimental medicine 2010;207(11):2355-67.
2010: David C Neujahr; Aminu Mohammed; Onome Ulukpo; Seth D Force; Allan M Ramirez; Andres Pelaez; E Clinton Lawrence; Christian P Larsen; Allan D Kirk
Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series.
Chest 2010;138(4):937-43.
2010: N A Turgeon; J G Avila; J A Cano; J J Hutchinson; I R Badell; A J Page; Andrew B Adams; M H Sears; P H Bowen; Allan D Kirk; Thomas C Pearson; Christian P Larsen
Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(9):2082-91.
2010: Flavio Vincenti; Gilles Blancho; Antoine Durrbach; Peter Friend; Josep M Grinyo; Philip F Halloran; Jurgen Klempnauer; Philippe Lang; Christian P Larsen; Ferdinand Mühlbacher; Björn Nashan; Jean-Paul Soulillou; Yves Vanrenterghem; Thomas Wekerle; Mamta Agarwal; Sheila Gujrathi; Jinshan Shen; Rebecca Shi; Robert Townsend; Bernard Charpentier
Five-year safety and efficacy of belatacept in renal transplantation.
Journal of the American Society of Nephrology : JASN 2010;21(9):1587-96.
2010: Ivana R Ferrer; Maylene E Wagener; Jennifer M Robertson; Alexa P Turner; Koichi Araki; Rafi Ahmed; Allan D Kirk; Christian P Larsen; Mandy L Ford
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2004-8.
2010: Mandy L Ford; Christian P Larsen
Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations.
Current opinion in organ transplantation 2010;15(4):405-10.
2010: Dexuan Ma; Minmin Zhang; Yoshimi Mori; Chengjun Yao; Christian P Larsen; Tetsumori Yamashima; Liangfu Zhou
Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia.
Hippocampus 2010;20(7):811-9.
2010: Tamara L Floyd; Steven B Orr; Shana M Coley; Samantha S Hanna; Maylene E Wagener; Allan D Kirk; Christian P Larsen; Mandy L Ford
High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
Transplantation 2010;89(10):1208-17.
2010: Dexuan Ma; Minmin Zhang; Christian P Larsen; Feng Xu; Wei Hua; Tetsumori Yamashima; Ying Mao; Liangfu Zhou
DHA promotes the neuronal differentiation of rat neural stem cells transfected with GPR40 gene.
Brain research 2010;1330():1-8.
2010: Flavio Vincenti; B Charpentier; Y Vanrenterghem; Lionel Rostaing; B Bresnahan; P Darji; P Massari; G A Mondragon-Ramirez; M Agarwal; G Di Russo; C-S Lin; P Garg; Christian P Larsen
A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(3):535-46.
2010: Henry Radziewicz; Chris C Ibegbu; Huiming Hon; Nathalie Bédard; Julie Bruneau; Kimberly A Workowski; Stuart J Knechtle; Allan D Kirk; Christian P Larsen; Naglaa H Shoukry; Arash Grakoui
Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2410-22.
2010: Diego R Martin; Saravanan K Krishnamoorthy; Bobby Kalb; Khalil Salman; Puneet Sharma; John D Carew; Phillip A Martin; Arlene B Chapman; Gaye L Ray; Christian P Larsen; Thomas C Pearson
Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols.
Journal of magnetic resonance imaging : JMRI 2010;31(2):440-6.
2009: Thomas G Heffron; John Rodriguez; Carlos G Fasola; Katherine Casper; Todd Pillen; Gregory A Smallwood; Barry L Warshaw; Rene Romero; Christian P Larsen
Successful outcome after early combined liver and en bloc-kidney transplant in an infant with primary hyperoxaluria type 1: a case report.
Pediatric transplantation 2009;13(7):940-2.
2009: David C Neujahr; Adriana C Cardona; Onome Ulukpo; Mark Rigby; Andres Pelaez; Allan Ramirez; Anthony A Gal; Seth D Force; E Clinton Lawrence; Allan D Kirk; Christian P Larsen
Dynamics of human regulatory T cells in lung lavages of lung transplant recipients.
Transplantation 2009;88(4):521-7.
2009: Christopher R Gilson; Zvonimir Milas; Shivaprakash Gangappa; Diane L Hollenbaugh; Thomas C Pearson; Mandy L Ford; Christian P Larsen
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1625-35.
2009: Koichi Araki; Alexandra P Turner; Virginia Oliva Shaffer; Shivaprakash Gangappa; Susanne A Keller; Martin F Bachmann; Christian P Larsen; Rafi Ahmed
mTOR regulates memory CD8 T-cell differentiation.
Nature 2009;460(7251):108-12.
2009: Tim A Weaver; Ali H Charafeddine; Avinash Agarwal; Alexandra P Turner; Maria Russell; Frank V Leopardi; Robert L Kampen; Linda Stempora; Mingqing Song; Christian P Larsen; Allan D Kirk
Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.
Nature medicine 2009;15(7):746-9.
2009: Mandy L Ford; Allan D Kirk; Christian P Larsen
Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.
Transplantation 2009;87(9 Suppl):S69-74.
2009: Mandy L Ford; Christian P Larsen
Translating costimulation blockade to the clinic: lessons learned from three pathways.
Immunological reviews 2009;229(1):294-306.
2009: Shana M Coley; Mandy L Ford; Samantha C Hanna; Maylene E Wagener; Allan D Kirk; Christian P Larsen
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):225-33.
2008: A Anderson; C L Martens; Rose Hendrix; L L Stempora; W P Miller; Kelly Hamby; M Russell; Elizabeth Strobert; Bruce R Blazar; Thomas C Pearson; Christian P Larsen; Leslie S Kean
Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(11):2252-64.
2008: Brent Howard Koehn; Mandy L Ford; Ivana R Ferrer; Keshawna Borom; Shivaprakash Gangappa; Allan D Kirk; Christian P Larsen
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5313-22.
2008: Bobby Kalb; Diego R Martin; Khalil Salman; Puneet Sharma; John Votaw; Christian P Larsen
Kidney transplantation: structural and functional evaluation using MR Nephro-Urography.
Journal of magnetic resonance imaging : JMRI 2008;28(4):805-22.
2008: Mark R Rigby; Alison M Trexler; Thomas C Pearson; Christian P Larsen
CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.
Diabetes 2008;57(10):2672-83.
2008: Fabienne Dobbels; Philip Moons; Ivo Abraham; Christian P Larsen; Lieven Dupont; Sabina De Geest
Measuring symptom experience of side-effects of immunosuppressive drugs: the Modified Transplant Symptom Occurrence and Distress Scale.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(8):764-73.
2008: Mandy L Ford; Maylene E Wagener; Samantha S Hanna; Thomas C Pearson; Allan D Kirk; Christian P Larsen
A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7203-11.
2008: Jens Wrammert; Kenneth Smith; Joe Miller; William A Langley; Kenneth E Kokko; Christian P Larsen; Nai-Ying Zheng; Israel Mays; Lori Garman; Christina Helms; Judith James; Gillian M Air; J Donald Capra; Rafi Ahmed; Patrick C Wilson
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.
Nature 2008;453(7195):667-71.
2008: Shivaprakash Gangappa; Kenneth E Kokko; Lisa M Carlson; Tania Gourley; Kenneth A Newell; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Immune responsiveness and protective immunity after transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(4):293-303.
2008: Shivaprakash Gangappa; Christian P Larsen
Immunosuppressive protocols for pig-to-human islet transplantation: lessons from pre-clinical non-human primate models.
Xenotransplantation 2008;15(2):107-11.
2008: Christian P Larsen; Roger moreira; Randolph A Hennigar; Vanesa Bijol
Kidney biopsy findings in a patient with fever, bilateral pulmonary infiltrates, and acute renal failure.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2008;51(3):524-9.
2008: Dale Stapler; Eun D Han Lee; Saranya A Selvaraj; Andrew G Evans; Leslie S Kean; Samuel H Speck; Christian P Larsen; Shivaprakash Gangappa
Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3190-200.
2008: Simon Mwangi; Mallappa Anitha; Chaithanya Mallikarjun; Xiaokun Ding; Manami Hara; Alexander Parsadanian; Christian P Larsen; Peter Thule; Shanthi V Sitaraman; Frank A Anania; Shanthi Srinivasan
Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.
Gastroenterology 2008;134(3):727-37.
2008: Juliet A Emamaullee; Shaheed Merani; Christian P Larsen; A M James Shapiro
Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity.
Transplantation 2008;85(1):118-24.
2008: Rebecca M LeLeiko; David J Bower; Christian P Larsen
MRSA-associated bacterial myocarditis causing ruptured ventricle and tamponade.
Cardiology 2008;111(3):188-90.
2007: Kenneth Cardona; Zvonimir Milas; Elizabeth Strobert; J Cano; Wanhong Jiang; Susan A Safley; Shivaprakash Gangappa; B J Hering; Collin J Weber; Thomas C Pearson; Christian P Larsen
Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(10):2260-8.
2007: Scott N Mueller; Mehrdad Matloubian; Daniel M Clemens; Arlene H Sharpe; Gordon J Freeman; Shivaprakash Gangappa; Christian P Larsen; Rafi Ahmed
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15430-5.
2007: Brent Howard Koehn; Matthew A Williams; Keshawna Borom; Shivaprakash Gangappa; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2616-26.
2007: Nagendra Singh; Phillip R Chandler; Yoichi Seki; Babak Baban; Mayuko Takezaki; David J Kahler; David H Munn; Christian P Larsen; Andrew L Mellor; Makio Iwashima
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Blood 2007;110(4):1199-206.
2007: Kelly Hamby; A Trexler; Thomas C Pearson; Christian P Larsen; Mark R Rigby; Leslie S Kean
NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(8):1884-96.
2007: Alan F Zahorchak; Leslie S Kean; Daisuke Tokita; Heth R Turnquist; Masanori Abe; Jennifer Finke; Kelly Hamby; Mark R Rigby; Christian P Larsen; Angus W Thomson
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Transplantation 2007;84(2):196-206.
2007: Kenneth A Newell; Christian P Larsen
Transplantation tolerance.
Seminars in nephrology 2007;27(4):487-97.
2007: Mandy L Ford; Maylene E Wagener; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(6):1471-81.
2007: Mandy L Ford; Brent Howard Koehn; Maylene E Wagener; Wanhong Jiang; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
The Journal of experimental medicine 2007;204(2):299-309.
2007: Leslie S Kean; Andrew B Adams; Elizabeth Strobert; Rose Hendrix; Shivaprakash Gangappa; Thomas R Jones; Nozomu Shirasugi; Mark R Rigby; Kelly Hamby; J Jiang; H Bello; Dan Anderson; Kenneth Cardona; Megan M Durham; Thomas C Pearson; Christian P Larsen
Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(2):320-35.
2007: S Gangappa; Christian P Larsen; Thomas C Pearson
Alloimmunity: no toll exemption.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(1):3-4.
2006: Jian-Ming Li; John Gorechlad; Christian P Larsen; Edmond WALLER
Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(12):1239-49.
2006: Vaiva Vezys; David Masopust; Christopher C Kemball; Daniel L Barber; Leigh A O'Mara; Christian P Larsen; Thomas C Pearson; Rafi Ahmed; Aron E Lukacher
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
The Journal of experimental medicine 2006;203(10):2263-9.
2006: Robert A. Bray; J D L Nolen; Christian P Larsen; Thomas C Pearson; Kenneth A Newell; Kenneth E Kokko; Antonio Guasch; P Tso; J B Mendel; Howard M. Gebel
Transplanting the highly sensitized patient: The emory algorithm.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(10):2307-15.
2006: K A Newell; Christian P Larsen
Toward transplantation tolerance: a large step on a long road.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):1989-90.
2006: Kenneth A Newell; Christian P Larsen
Tolerance assays: measuring the unknown.
Transplantation 2006;81(11):1503-9.
2006: E D Han Lee; Christopher C Kemball; Jun Wang; Ying Dong; D C Stapler; Kelly Hamby; Shivaprakash Gangappa; Kenneth A Newell; Thomas C Pearson; Aron E Lukacher; Christian P Larsen
A mouse model for polyomavirus-associated nephropathy of kidney transplants.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):913-22.
2006: Leslie S Kean; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Transplant tolerance in non-human primates: progress, current challenges and unmet needs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):884-93.
2006: Christian P Larsen; Stuart J Knechtle; A Adams; Thomas C Pearson; Allan D Kirk
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):876-83.
2006: Kenneth Cardona; Gregory S Korbutt; Zvonimir Milas; James Lyon; Jose Cano; Wanhong Jiang; Hameeda Bello-Laborn; Brad Hacquoil; Elizabeth Strobert; Shivaprakash Gangappa; Collin J Weber; Thomas C Pearson; Ray V Rajotte; Christian P Larsen
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
Nature medicine 2006;12(3):304-6.
2006: Brent Howard Koehn; Shivaprakash Gangappa; Joeseph D Miller; Rafi Ahmed; Christian P Larsen
Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2691-6.
2006: Nikos Emmanouilidis; Zhong Guo; Ying Dong; Marvin Newton-West; Andrew B Adams; Eun D Han Lee; Jun Wang; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells.
Transplantation 2006;81(3):455-62.
2006: Leslie S Kean; Kelly Hamby; Brent Howard Koehn; E Lee; S Coley; L Stempora; Andrew B Adams; E Heiss; Thomas C Pearson; Christian P Larsen
NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(2):292-304.
2006: Christopher C Kemball; Eun D Han Lee; Eva Szomolanyi-Tsuda; Thomas C Pearson; Christian P Larsen; Aron E Lukacher
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1814-24.
2006: Kenneth A Newell; Christian P Larsen; Allan D Kirk
Transplant tolerance: converging on a moving target.
Transplantation 2006;81(1):1-6.
2005: Flavio Vincenti; Christian P Larsen; Antoine Durrbach; Thomas Wekerle; Björn Nashan; Gilles Blancho; Philippe Lang; Josep M Grinyo; Philip F Halloran; Kim Solez; David Hagerty; Elliott Levy; Wenjiong Zhou; Kannan Natarajan; Bernard Charpentier
Costimulation blockade with belatacept in renal transplantation.
The New England journal of medicine 2005;353(8):770-81.
2005: Christopher C Kemball; Eun D Han Lee; Vaiva Vezys; Thomas C Pearson; Christian P Larsen; Aron E Lukacher
Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7950-60.
2005: Christian P Larsen; Thomas C Pearson; Andrew B Adams; Paul Tso; Nozomu Shirasugi; Elizabeth Strobert; Dan Anderson; Shannon Cowan; Karen Price; Joseph Naemura; John Emswiler; JoAnne Greene; Lori Ann Turk; Jurgen Bajorath; Robert Townsend; David Hagerty; Peter Linsley; Robert Peach
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(3):443-53.
2005: Christian P Larsen; F Ezligini; N O Hermansen; Jens Kjeldsen-Kragh
Six years' experience of using the BacT/ALERT system to screen all platelet concentrates, and additional testing of outdated platelet concentrates to estimate the frequency of false-negative results.
Vox sanguinis 2005;88(2):93-7.
2005: Zhenhua Dai; Isam W Nasr; Michael Reel; Songyan Deng; Lonnette Diggs; Christian P Larsen; David M Rothstein; Fadi G Lakkis
Impaired recall of CD8 memory T cells in immunologically privileged tissue.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1165-70.
2005: Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Megan M Durham; Elizabeth Strobert; Shannon Cowan; Phyllis Rees; Rose Hendrix; Karen Price; Norma S Kenyon; David Hagerty; Robert Townsend; Diane L Hollenbaugh; Thomas C Pearson; Christian P Larsen
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):542-50.
2005: Nikos Emmanouilidis; Christian P Larsen
Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice.
Methods in molecular medicine 2005;109():459-68.
2004: Nozomu Shirasugi; Nikos Emmanouilidis; Thomas C Pearson; Christian P Larsen
Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.
Transplantation proceedings 2004;36(8):2423-4.
2004: Sulaiman A Nanji; Wayne W Hancock; Colin C Anderson; Andrew B Adams; Bin Luo; Colleen D Schur; Rena L Pawlick; Liqing Wang; Anthony J Coyle; Christian P Larsen; A M James Shapiro
Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(4):526-36.
2004: David A Garber; Guido Silvestri; Ashley P Barry; Andrew Fedanov; Natalia Kozyr; Harold M McClure; David C Montefiori; Christian P Larsen; John D Altman; Silvija I Staprans; Mark B Feinberg
Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication.
The Journal of clinical investigation 2004;113(6):836-45.
2003: Leslie S Kean; Elizabeth A Manci; Jennifer Perry; Can Balkan; Shana Coley; David Holtzclaw; Andrew B Adams; Christian P Larsen; Lewis Hsu; David R Archer
Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.
Blood 2003;102(13):4582-93.
2003: Thomas R Jones; Nozomu Shirasugi; Andrew B Adams; Thomas C Pearson; Christian P Larsen
Intravital microscopy identifies selectins that regulate T cell traffic into allografts.
The Journal of clinical investigation 2003;112(11):1714-23.
2003: Thomas R Jones; Andrew B Adams; Nozomu Shirasugi; Adam W Bingaman; Megan M Durham; Thomas C Pearson; Christian P Larsen
Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(12):1520-30.
2003: Andrew B Adams; Thomas C Pearson; Christian P Larsen
Heterologous immunity: an overlooked barrier to tolerance.
Immunological reviews 2003;196():147-60.
2003: Paul L Tso; Michael P Cash; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Simultaneous pancreas-kidney transplantation utilizing a common arterial conduit: early experience and potential applications.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(11):1440-3.
2003: Zhong Guo; Jun Wang; Ying Dong; Andrew B Adams; Nozomu Shirasugi; Oliver Kim; John Hart; Marvin Newton-West; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1091-8.
2003: Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Matthew A Williams; Megan M Durham; Jongwon Ha; Ying Dong; Zhong Guo; Kenneth A Newell; Thomas C Pearson; Christian P Larsen
Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):895-901.
2003: Andrew B Adams; Matthew A Williams; Thomas R Jones; Nozomu Shirasugi; Megan M Durham; Susan M Kaech; E John Wherry; Thandi M Onami; J Gibson Lanier; Kenneth E Kokko; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Heterologous immunity provides a potent barrier to transplantation tolerance.
The Journal of clinical investigation 2003;111(12):1887-95.
2003: Lena C Larsson; Matthias Corbascio; Thomas C Pearson; Christian P Larsen; Henrik Ekberg; Håkan Widner
Induction of operational tolerance to discordant dopaminergic porcine xenografts.
Transplantation 2003;75(9):1448-54.
2003: Jun Wang; Zhong Guo; Ying Dong; Oliver Kim; John Hart; Andrew Adams; Christian P Larsen; Robert S Mittler; Kenneth A Newell
Role of 4-1BB in allograft rejection mediated by CD8+ T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(5):543-51.
2003: Lennart Lögdberg; Stephen L Sgan; Christian P Larsen; Christopher D Hillyer
Islet transplantation, stem cells, and transfusion medicine.
Transfusion medicine reviews 2003;17(2):95-109.
2003: Matthew A Williams; Andrew B Adams; Melody B Walsh; Nozomu Shirasugi; Thandi M Onami; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Primary and secondary immunocompetence in mixed allogeneic chimeras.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2382-9.
2002: Matthew A Williams; Thandi M Onami; Andrew B Adams; Megan M Durham; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5387-91.
2002: Thomas C Pearson; Joel Trambley; Kris Odom; Daniel Anderson; Shannon Cowan; Robert A. Bray; Angello Lin; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; Elizabeth Strobert; Randolph A Hennigar; Christian P Larsen
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation 2002;74(7):933-40.
2002: Jack L Arbiser; Adam W Bingaman; Megan M Durham; Shannon Cowan; Cynthia Cohen; Elham Zarnegar; Vijay Varma; Christian P Larsen
SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways.
Molecular medicine (Cambridge, Mass.) 2002;8(9):551-8.
2002: Nozomu Shirasugi; Andrew B Adams; Megan M Durham; Aron E Lukacher; Huaying Xu; Phyllis Rees; Shannon Cowan; Matthew A Williams; Thomas C Pearson; Christian P Larsen
Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2677-84.
2002: Matthias Corbascio; Harish D Mahanty; Cecilia Osterholm; Zhongquan Qi; Thomas C Pearson; Christian P Larsen; Chris E Freise; Henrik Ekberg
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.
Transplantation 2002;74(1):35-41.
2002: Thandi M Onami; Laurie E Harrington; Matthew A Williams; Marisa Galvan; Christian P Larsen; Thomas C Pearson; N Manjunath; Linda G Baum; Brad D Pearce; Rafi Ahmed
Dynamic regulation of T cell immunity by CD43.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6022-31.
2002: Matthias Corbascio; Helene Ekstrand; Cecilia Osterholm; Zhongquan Qi; Mecislovas Simanaitis; Christian P Larsen; Thomas C Pearson; Kristian Riesbeck; Henrik Ekberg
CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely.
Transplant immunology 2002;10(1):55-61.
2002: Leslie S Kean; Megan M Durham; Andrew B Adams; Lewis Hsu; Jennifer R Perry; Dirck L Dillehay; Thomas C Pearson; Edmond WALLER; Christian P Larsen; David R Archer
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.
Blood 2002;99(5):1840-9.
2002: Andrew B Adams; Nozomu Shirasugi; Megan M Durham; Elizabeth Strobert; Dan Anderson; Phyllis Rees; Shannon Cowan; Huaying Xu; Yelena Blinder; Michael Cheung; Diane L Hollenbaugh; Norma S Kenyon; Thomas C Pearson; Christian P Larsen
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.
Diabetes 2002;51(2):265-70.
2002: Thomas R Jones; Jongwon Ha; Matthew A Williams; Andrew B Adams; Megan M Durham; Phyllis Rees; Shannon Cowan; Thomas C Pearson; Christian P Larsen
The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1123-30.
2002: Helene Malm; Matthias Corbascio; Cecilia Osterholm; Shannon Cowan; Christian P Larsen; Thomas C Pearson; Henrik Ekberg
CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice.
Transplantation 2002;73(2):293-7.
2002: Andrew B Adams; Christian P Larsen; Thomas C Pearson; Kenneth A Newell
The role of TNF receptor and TNF superfamily molecules in organ transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(1):12-8.
2002: Lena C Larsson; Matthias Corbascio; Håkan Widner; Thomas C Pearson; Christian P Larsen; Henrik Ekberg
Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L.
Xenotransplantation 2002;9(1):68-76.
2001: M Suresh; Jason K Whitmire; Laurie E Harrington; Christian P Larsen; Thomas C Pearson; John D Altman; Rafi Ahmed
Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5565-73.
2001: Matthew A Williams; Joyce T Tan; Andrew B Adams; Megan M Durham; Nozomu Shirasugi; Jason K Whitmire; Laurie E Harrington; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4987-95.
2001: Adam W Bingaman; Jongwon Ha; Megan M Durham; SY Waitze; Carol Tucker-Burden; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4+ T cells in vivo.
Transplantation 2001;72(7):1286-92.
2001: Jongwon Ha; Adam W Bingaman; Megan M Durham; Thomas C Pearson; Christian P Larsen
Aggressive skin allograft rejection in CD28-/- mice independent of the CD40/CD40L costimulatory pathway.
Transplant immunology 2001;9(1):13-7.
2001: Enver Akalin; Rose Hendrix; Rohini Polavarapu; Thomas C Pearson; John F Neylan; Christian P Larsen; Fadi G Lakkis
Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology.
Transplantation 2001;72(5):948-53.
2001: Andrew B Adams; Megan M Durham; Leslie S Kean; Nozomu Shirasugi; Jongwon Ha; Matthew A Williams; Phyllis Rees; M C Cheung; Stephen Mittelstaedt; Adam W Bingaman; David R Archer; Thomas C Pearson; Edmond WALLER; Christian P Larsen
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1103-11.
2001: Andrew B Adams; Thomas C Pearson; Christian P Larsen
Conventional immunosuppression and co-stimulation blockade.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):703-5.
2001: Zhong Guo; L Meng; Oliver Kim; Jun Wang; John Hart; Gang He; Maria-Luisa Alegre; J Richard Thistlethwaite; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Transplantation 2001;71(9):1351-4.
2001: William M Baldwin; Christian P Larsen; R L Fairchild
Innate immune responses to transplants: a significant variable with cadaver donors.
Immunity 2001;14(4):369-76.
2001: S Akbulut; C A Byersdorfer; Christian P Larsen; S L Zimmer; T D Humphreys; Benjamin L Clarke
Expression of the melanocortin 5 receptor on rat lymphocytes.
Biochemical and biophysical research communications 2001;281(5):1086-92.
2001: Joel Trambley; Angello Lin; Eric T. Elwood; Adam W Bingaman; Fadi G Lakkis; Matthias Corbascio; Thomas C Pearson; Christian P Larsen
FasL is important in costimulation blockade-resistant skin graft rejection.
Transplantation 2001;71(4):537-43.
2001: L Meng; Zhong Guo; Oliver Kim; Gang He; John Hart; Gregory L Szot; Jun Wang; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection.
Transplantation proceedings 2001;33(1-2):418-20.
2000: Matthew A Williams; Joel Trambley; Jongwon Ha; Andrew B Adams; Megan M Durham; Phyllis Rees; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6849-57.
2000: Adam W Bingaman; Thomas C Pearson; Christian P Larsen
The role of CD40L in T cell-dependent nitric oxide production by murine macrophages.
Transplant immunology 2000;8(3):195-202.
2000: H L Triemer; Thomas C Pearson; K L Odom; Christian P Larsen
Analysis of a single-center experience with mycophenolate mofetil based immunosuppression in renal transplantation.
Clinical transplantation 2000;14(4 Pt 2):413-20.
2000: Joyce T Tan; Jongwon Ha; Hong Rae Cho; Carol Tucker-Burden; Rose Hendrix; Robert S Mittler; Thomas C Pearson; Christian P Larsen
Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.
Transplantation 2000;70(1):175-83.
2000: Megan M Durham; Adam W Bingaman; Andrew B Adams; Jongwon Ha; SY Waitze; Thomas C Pearson; Christian P Larsen
Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):1-4.
2000: Adam W Bingaman; SY Waitze; DZ Alexander; Hong Rae Cho; Angello Lin; Carol Tucker-Burden; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism without cytoreductive conditioning.
Transplantation 2000;69(12):2491-6.
2000: Adam W Bingaman; Jongwon Ha; SY Waitze; Megan M Durham; Hong Rae Cho; Carol Tucker-Burden; Rose Hendrix; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Vigorous allograft rejection in the absence of danger.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3065-71.
2000: Joyce T Tan; Jason K Whitmire; Kaja Murali-Krishna; Rafi Ahmed; John D Altman; Robert S Mittler; Alessandro Sette; Thomas C Pearson; Christian P Larsen
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2320-5.
1999: Joel Trambley; Adam W Bingaman; Angello Lin; Eric T. Elwood; SY Waitze; Jongwon Ha; Megan M Durham; Matthias Corbascio; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.
The Journal of clinical investigation 1999;104(12):1715-22.
1999: Joyce T Tan; Jason K Whitmire; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4859-68.
1999: Jason K Whitmire; Richard A Flavell; Iqbal Grewal; Christian P Larsen; Thomas C Pearson; Rafi Ahmed
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3194-201.
1998: M Niimi; Thomas C Pearson; Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Alejandro Aruffo; Peter Linsley; E Thomas; K Campbell; W C Fanslow; R S Geha; Peter J Morris; Kathryn J Wood
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: Eric T. Elwood; Christian P Larsen; Hong Rae Cho; Matthias Corbascio; S C Ritchie; DZ Alexander; Carol Tucker-Burden; Peter Linsley; Alejandro Aruffo; Diane L Hollenbaugh; K J Winn; Thomas C Pearson
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: Bogumila T Konieczny; Zhenhua Dai; Eric T. Elwood; S Saleem; Peter Linsley; Fady K Baddoura; Christian P Larsen; Thomas C Pearson; Fadi G Lakkis
IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2059-64.
1997: Christian P Larsen; Thomas C Pearson
The CD40 pathway in allograft rejection, acceptance, and tolerance.
Current opinion in immunology 1997;9(5):641-7.
1997: WW Shuford; K Klussman; D D Tritchler; DT Loo; J Chalupny; Anthony W Siadak; T J Brown; John Emswiler; H Raecho; Christian P Larsen; Thomas C Pearson; Jeffrey A Ledbetter; Alejandro Aruffo; Robert S Mittler
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
1997: Thomas C Pearson; P J Santamaria; K L Routenberg; D P O'Brien; John Whelchel; John F Neylan; Christian P Larsen
Drainage of the exocrine pancreas in clinical transplantation: comparison of bladder versus enteric drainage in a consecutive series.
Clinical transplantation 1997;11(3):201-5.
1997: Thomas C Pearson; DZ Alexander; Matthias Corbascio; Rose Hendrix; S C Ritchie; Peter Linsley; D Faherty; Christian P Larsen
Analysis of the B7 costimulatory pathway in allograft rejection.
Transplantation 1997;63(10):1463-9.
1997: Eric T. Elwood; Christian P Larsen; D H Maurer; K L Routenberg; John F Neylan; John Whelchel; D P O'Brien; Thomas C Pearson
Microchimerism and rejection in clinical transplantation.
Lancet 1997;349(9062):1358-60.
1997: Fadi G Lakkis; Bogumila T Konieczny; S Saleem; Fady K Baddoura; Peter Linsley; DZ Alexander; R P Lowry; Thomas C Pearson; Christian P Larsen
Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2443-8.
1996: Christian P Larsen; Eric T. Elwood; DZ Alexander; S C Ritchie; R Hendrix; Carol Tucker-Burden; H R Cho; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; K J Winn; Thomas C Pearson
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Thomas C Pearson; DZ Alexander; R Hendrix; Eric T. Elwood; Peter Linsley; K J Winn; Christian P Larsen
CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism.
Transplantation 1996;61(7):997-1004.
1996: Collin J Weber; M K Hagler; J T Chryssochoos; Christian P Larsen; Thomas C Pearson; P Jensen; Judith A Kapp; Peter Linsley
CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice.
Transplantation proceedings 1996;28(2):821-3.
1996: DZ Alexander; Thomas C Pearson; R Hendrix; S C Ritchie; Christian P Larsen
Analysis of effector mechanisms in murine cardiac allograft rejection.
Transplant immunology 1996;4(1):46-8.
1996: Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Eric T. Elwood; S C Ritchie; Alejandro Aruffo; R Hendrix; Thomas C Pearson
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation 1996;61(1):4-9.
1996: John Whelchel; L C Hymes; E L Hochgelerent; Christian P Larsen; D C Lowance; D P O'Brien; John F Neylan; Thomas C Pearson; Barry L Warshaw
Evolving strategies in immunosuppressive therapy: the Emory experience.
Clinical transplants 1996;():249-55.
1995: Angus W Thomson; Lina Lu; Y Wan; Shiguang Qian; Christian P Larsen; Thomas E Starzl
Identification of donor-derived dendritic cell progenitors in bone marrow of spontaneously tolerant liver allograft recipients.
Transplantation 1995;60(12):1555-9.
1995: Thomas C Pearson; A A Futral; K L Routenberg; D P O'Brien; John Whelchel; John F Neylan; Christian P Larsen
Delayed urinary bladder leak after combined kidney-pancreas transplantation. Association with penile prosthesis implantation.
Transplantation 1995;60(6):624-6.
1995: Christian P Larsen; DZ Alexander; R Hendrix; S C Ritchie; Thomas C Pearson
Fas-mediated cytotoxicity. An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses?
Transplantation 1995;60(3):221-4.
1995: JA Roake; A S Rao; Peter J Morris; Christian P Larsen; D F Hankins; Jonathan M Austyn
Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.
The Journal of experimental medicine 1995;181(6):2237-47.
1995: JA Roake; A S Rao; Peter J Morris; Christian P Larsen; D F Hankins; Jonathan M Austyn
Systemic lipopolysaccharide recruits dendritic cell progenitors to nonlymphoid tissues.
Transplantation 1995;59(9):1319-24.
1995: R P Lowry; Bogumila T Konieczny; D Alexander; Christian P Larsen; Thomas C Pearson; S Smith; S Narula
Interleukin-10 eliminates anti-CD3 monoclonal antibody-induced mortality and prolongs heart allograft survival in inbred mice.
Transplantation proceedings 1995;27(1):392-4.
1995: David A Gerber; Carl W Oettinger; Martin J D'Souza; GV Milton; Christian P Larsen; Thomas C Pearson
Prolongation of murine cardiac allograft survival by microspheres containing TNF alpha and IL1-beta neutralizing antibodies.
Journal of drug targeting 1995;3(4):311-5.
1994: Thomas C Pearson; DZ Alexander; K J Winn; Peter Linsley; R P Lowry; Christian P Larsen
Transplantation tolerance induced by CTLA4-Ig.
Transplantation 1994;57(12):1701-6.
1994: Christian P Larsen; S C Ritchie; R Hendrix; Peter Linsley; K S Hathcock; Richard J Hodes; R P Lowry; Thomas C Pearson
Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5208-19.
1994: Jonathan M Austyn; D F Hankins; Christian P Larsen; Peter J Morris; A S Rao; JA Roake
Isolation and characterization of dendritic cells from mouse heart and kidney.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2401-10.
1993: A S Rao; JA Roake; Christian P Larsen; D F Hankins; Peter J Morris; Jonathan M Austyn
Isolation of dendritic leukocytes from non-lymphoid organs.
Advances in experimental medicine and biology 1993;329():507-12.
1993: JA Roake; A S Rao; Christian P Larsen; D F Hankins; Peter J Morris; Jonathan M Austyn
Cytokine mediators of non-lymphoid dendritic cell migration.
Advances in experimental medicine and biology 1993;329():501-6.
1993: John Whelchel; John F Neylan; E D Frederickson; E L Hochgelerent; L C Hymes; Christian P Larsen; D C Lowance; R P Lowry; D P O'Brien; Barry L Warshaw
Racial issues in renal transplantation: the Emory University experience.
Clinical transplants 1993;():253-8.
1992: Christian P Larsen; S C Ritchie; Thomas C Pearson; Peter Linsley; R P Lowry
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
The Journal of experimental medicine 1992;176(4):1215-20.
1992: Thomas C Pearson; J C Madsen; Christian P Larsen; Peter J Morris; Kathryn J Wood
Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody.
Transplantation 1992;54(3):475-83.
1991: Margaret J Dallman; Christian P Larsen; Peter J Morris
Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.
The Journal of experimental medicine 1991;174(2):493-6.
1991: P F Brown; Christian P Larsen; Panagiotis N Symbas
Management of the asymptomatic patient with a stab wound to the chest.
Southern medical journal 1991;84(5):591-3.
1991: Margaret J Dallman; Robert A Montgomery; Christian P Larsen; A Wanders; A F Wells
Cytokine gene expression: analysis using northern blotting, polymerase chain reaction and in situ hybridization.
Immunological reviews 1991;119():163-79.
1991: Christian P Larsen; Jonathan M Austyn
Langerhans cells migrate out of skin grafts and cultured skin: a model in which to study the mediators of dendritic leukocyte migration.
Transplantation proceedings 1991;23(1 Pt 1):117-9.
1990: Christian P Larsen; R M Steinman; M Witmer-Pack; D F Hankins; Peter J Morris; Jonathan M Austyn
Migration and maturation of Langerhans cells in skin transplants and explants.
The Journal of experimental medicine 1990;172(5):1483-93.
1990: Christian P Larsen; Jonathan M Austyn; Peter J Morris
The role of graft-derived dendritic leukocytes in the rejection of vascularized organ allografts. Recent findings on the migration and function of dendritic leukocytes after transplantation.
Annals of surgery 1990;212(3):308-15; discussion 316-7.
1990: Christian P Larsen; Peter J Morris; Jonathan M Austyn
Donor dendritic leukocytes migrate from cardiac allografts into recipients' spleens.
Transplantation proceedings 1990;22(4):1943-4.
1990: Christian P Larsen; H Barker; Peter J Morris; Jonathan M Austyn
Failure of mature dendritic cells of the host to migrate from the blood into cardiac or skin allografts.
Transplantation 1990;50(2):294-301.
1990: Jonathan M Austyn; Christian P Larsen
Migration patterns of dendritic leukocytes. Implications for transplantation.
Transplantation 1990;49(1):1-7.
1990: Christian P Larsen; Peter J Morris; Jonathan M Austyn
Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
The Journal of experimental medicine 1990;171(1):307-14.
1989: Margaret J Dallman; Andrew C G Porter; Christian P Larsen; Peter J Morris
Lymphokine production in allografts--analysis of RNA by northern blotting.
Transplantation proceedings 1989;21(1 Pt 1):296-8.
1986: R J Bloom; Christian P Larsen; R Watt; H A Oberhelman
A reappraisal of the Kock continent ileostomy in patients with Crohn's disease.
Surgery, gynecology & obstetrics 1986;162(2):105-8.