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Reed Larsen

Research Profile

Chemicals & Drugs

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Rats
Mouse

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Hypothyroidism

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Alessandro Marsili; Edith Sanchez; Praful Singru; Ann Marie Zavacki; John W Harney; Ronald M Lechan; P Reed Larsen
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
Simone Magagnin Wajner; Iuri Martin Goemann; Ana Laura Bueno; P Reed Larsen; Ana Luiza Maia
IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells.
A Marsili; Ann Marie Zavacki; John W Harney; P Reed Larsen
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.

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2011: Alessandro Marsili; Edith Sanchez; Praful Singru; Ann Marie Zavacki; John W Harney; Ronald M Lechan; P Reed Larsen
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
The Journal of endocrinology 2011;211(1):73-8.
2011: Simone Magagnin Wajner; Iuri Martin Goemann; Ana Laura Bueno; P Reed Larsen; Ana Luiza Maia
IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells.
The Journal of clinical investigation 2011;121(5):1834-45.
2011: A Marsili; Ann Marie Zavacki; John W Harney; P Reed Larsen
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
Journal of endocrinological investigation 2011;34(5):395-407.
2011: Michael H Roh; Vickie Y Jo; Edward B Stelow; William C Faquin; Kelly H Zou; Erik K Alexander; P Reed Larsen; Ellen Marqusee; Carol B Benson; Mary C Frates; Atul Gawande; Francis D Moore; Edmund S Cibas
The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis.
American journal of clinical pathology 2011;135(1):139-45.
2010: Alessandro Marsili; Waile Ramadan; John W Harney; Michelle Mulcahey; Luciana Audi Castroneves; Iuri Martin Goemann; Simone Magagnin Wajner; Stephen A Huang; Ann Marie Zavacki; Ana Luiza Maia; Monica Dentice; Domenico Salvatore; J Enrique Silva; P Reed Larsen
Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.
Endocrinology 2010;151(12):5952-60.
2010: Monica Dentice; Alessandro Marsili; Raffaele Ambrosio; Ombretta Guardiola; Annarita Sibilio; Ji-Hye Paik; Gabriella Minchiotti; Ronald A DePinho; Gianfranco Fenzi; P Reed Larsen; Domenico Salvatore
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.
The Journal of clinical investigation 2010;120(11):4021-30.
2010: Andrea Kádár; Edith Sánchez; Gábor Wittmann; Praful Singru; Tamás Füzesi; Alessandro Marsili; P Reed Larsen; Zsolt Liposits; Ronald M Lechan; Csaba Fekete
Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse.
The Journal of comparative neurology 2010;518(19):3948-61.
2010: Iuri Martin Goemann; Balázs Gereben; John W Harney; Bo Zhu; Ana Luiza Maia; P Reed Larsen
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells.
Endocrinology 2010;151(2):821-9.
2009: Mary-Elizabeth Patti; Sander M Houten; Antonio Bianco; Raquel Bernier; P Reed Larsen; Jens J Holst; Michael K Badman; Eleftheria Maratos-Flier; Edward C Mun; Jussi Pihlajamaki; Johan Auwerx; Allison B Goldfine
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Obesity (Silver Spring, Md.) 2009;17(9):1671-7.
2009: Nagaoki Toyoda; Saori Yasuzawa-Amano; Emiko Nomura; Azusa Yamauchi; Kumiko Nishimura; Chizuko Ukita; Satoshi Morimoto; Atsushi Kosaki; Toshiji Iwasaka; John W Harney; P Reed Larsen; Mitsushige Nishikawa
Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid.
Thyroid : official journal of the American Thyroid Association 2009;19(7):755-63.
2009: P Reed Larsen
Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation.
The Journal of clinical endocrinology and metabolism 2009;94(6):1893-5.
2008: P Reed Larsen
Endocrinology and oncology: closer ties will be mutually beneficial.
Nature clinical practice. Endocrinology & metabolism 2008;4(11):585.
2008: Jan Wolff; P Reed Larsen
Dr Joseph Edward Rall.
Nature clinical practice. Endocrinology & metabolism 2008;4(7):359.
2008: G D Vivek Sagar; Balázs Gereben; Isabelle Callebaut; Jean-Paul Mornon; Anikó Zeöld; Cyntia Curcio-Morelli; John W Harney; Cristina Luongo; Michelle A Mulcahey; P Reed Larsen; Stephen A Huang; Antonio Bianco
The thyroid hormone-inactivating deiodinase functions as a homodimer.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1382-93.
2008: P Reed Larsen
Insights from the 78(th) Annual Meeting of the American Thyroid Association.
Nature clinical practice. Endocrinology & metabolism 2008;4(4):179.
2008: Ana Luiza Maia; Shih-Jen Hwang; Daniel Levy; Martin G Larson; P Reed Larsen; Caroline S Fox
Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study.
Hypertension 2008;51(4):e22-3.
2008: Warner S Simonides; Michelle A Mulcahey; Everaldo M Redout; Alice Muller; Marian J Zuidwijk; Theo J Visser; Frank W J S Wassen; Alessandra Crescenzi; Wagner S da-Silva; John Harney; Felix B Engel; Maria Jesus Obregón; P Reed Larsen; Antonio Bianco; Stephen A Huang
Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
The Journal of clinical investigation 2008;118(3):975-83.
2008: P Reed Larsen; John D Baxter
Cardiovascular and metabolic issues in patients with thyroid dysfunction will be highlighted at the Fifth Anniversary of ATA Spring Meetings in March 2008.
Thyroid : official journal of the American Thyroid Association 2008;18(2):101.
2008: Gianluca Canettieri; Antonella Franchi; Michele Della Guardia; Ianessa Morantte; Maria Giulia Santaguida; John W Harney; P Reed Larsen; Marco Centanni
Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells.
Endocrinology 2008;149(2):695-702.
2007: Leila Yassa; Edmund S Cibas; Carol B Benson; Mary C Frates; Peter M Doubilet; Atul A Gawande; Francis D Moore; Brian W. Kim; Vânia Nosé; Ellen Marqusee; P Reed Larsen; Erik K Alexander
Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation.
Cancer 2007;111(6):508-16.
2007: Monica Dentice; Cristina Luongo; Stephen Huang; Raffaele Ambrosio; Andrea Elefante; Delphine Mirebeau-Prunier; Ann Marie Zavacki; Gianfranco Fenzi; Marina Grachtchouk; Mark E Hutchin; Andrzej Dlugosz; Antonio Bianco; Caterina Missero; P Reed Larsen; Domenico Salvatore
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14466-71.
2007: P Reed Larsen
Thyroid physiology becomes more complicated.
Nature clinical practice. Endocrinology & metabolism 2007;3(7):495.
2007: Ana Luiza Maia; Josée Dupuis; Alisa Manning; Chunyu Liu; James B Meigs; L Adrienne Cupples; P Reed Larsen; Caroline S Fox
The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.
Thyroid : official journal of the American Thyroid Association 2007;17(3):199-202.
2007: P Reed Larsen
Insights from the 77th annual meeting of the American Thyroid Association.
Nature clinical practice. Endocrinology & metabolism 2007;3(3):197.
2007: Marcelo A Christoffolete; Rafael Arrojo e Drigo; Fernanda Gazoni; Susana M Tente; Vanessa Goncalves; Beatriz S Amorim; P Reed Larsen; Antonio Bianco; Ann Marie Zavacki
Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.
Endocrinology 2007;148(3):954-60.
2006: Mary C Frates; Carol B Benson; J William Charboneau; Edmund S Cibas; Orlo H Clark; Beverly G Coleman; John J Cronan; Peter M Doubilet; Douglas B Evans; John R Goellner; Ian D Hay; Barbara S Hertzberg; Charles M Intenzo; R Brooke Jeffrey; Jill E Langer; P Reed Larsen; Susan J Mandel; William D Middleton; Carl C Reading; Steven I Sherman; Franklin N Tessler
Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement.
Ultrasound quarterly 2006;22(4):231-8; discussion 239-40.
2006: Jayesh Desai; Leila Yassa; Ellen Marqusee; Suzanne George; Mary C Frates; Ming Hui Chen; Jeffrey A Morgan; Samuel Dychter; P Reed Larsen; George D Demetri; Erik K Alexander
Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.
Annals of internal medicine 2006;145(9):660-4.
2006: P Reed Larsen; Ian Newman
Good news from MEDLINE--and how you can help us stay one step ahead.
Nature clinical practice. Endocrinology & metabolism 2006;2(9):471.
2006: Mary C Frates; Carol B Benson; Peter M Doubilet; Elizabeth Kunreuther; Maricela Contreras; Edmund S Cibas; Joseph Orcutt; Francis D Moore; P Reed Larsen; Ellen Marqusee; Erik K Alexander
Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography.
The Journal of clinical endocrinology and metabolism 2006;91(9):3411-7.
2006: P Reed Larsen
New guidelines for patients with thyroid nodules and differentiated thyroid cancer.
Nature clinical practice. Endocrinology & metabolism 2006;2(6):297.
2006: Marcelo A Christoffolete; Rogério Ribeiro; Praful Singru; Csaba Fekete; Wagner S da-Silva; David F Gordon; Stephen A Huang; Alessandra Crescenzi; John W Harney; E Chester Ridgway; P Reed Larsen; Ronald M Lechan; Antonio Bianco
Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
Endocrinology 2006;147(4):1735-43.
2006: P Reed Larsen
Detecting and treating hypothyroidism during pregnancy.
Nature clinical practice. Endocrinology & metabolism 2006;2(2):59.
2005: P Reed Larsen
Insights from the ENDO 2005 meeting.
Nature clinical practice. Endocrinology & metabolism 2005;1(2):59.
2005: Mary C Frates; Carol B Benson; J William Charboneau; Edmund S Cibas; Orlo H Clark; Beverly G Coleman; John J Cronan; Peter M Doubilet; Douglas B Evans; John R Goellner; Ian D Hay; Barbara S Hertzberg; Charles M Intenzo; R Brooke Jeffrey; Jill E Langer; P Reed Larsen; Susan J Mandel; William D Middleton; Carl C Reading; Steven I Sherman; Franklin N Tessler
Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement.
Radiology 2005;237(3):794-800.
2005: Stephen A Huang; Michelle A Mulcahey; Alessandra Crescenzi; Mirra Chung; Brian W. Kim; Carmen M. Barnes; Wichert Kuijt; Helen Turano; John W Harney; P Reed Larsen
Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3126-36.
2005: Ana Luiza Maia; Brian W. Kim; Stephen A Huang; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.
The Journal of clinical investigation 2005;115(9):2524-33.
2005: Antonio Bianco; P Reed Larsen
Cellular and structural biology of the deiodinases.
Thyroid : official journal of the American Thyroid Association 2005;15(8):777-86.
2005: Luís Henrique Canani; Clarissa Capp; José Miguel Dora; Erika L Souza Meyer; Márcia S Wagner; John W Harney; P Reed Larsen; Jorge L Gross; Antonio Bianco; Ana Luiza Maia
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2005;90(6):3472-8.
2005: Ann Marie Zavacki; P Reed Larsen
CARs and drugs: a risky combination.
Endocrinology 2005;146(3):992-4.
2005: Ann Marie Zavacki; Hao Ying; Marcelo A Christoffolete; Goele Aerts; Edward C So; John W Harney; Sheue-Yann Cheng; P Reed Larsen; Antonio Bianco
Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
Endocrinology 2005;146(3):1568-75.
2004: Sung-Woo Kim; Seong-June Hong; Kyung Min Kim; Sung-Chul Ho; Edward C So; John W Harney; P Reed Larsen
A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene.
Molecular endocrinology (Baltimore, Md.) 2004;18(12):2924-36.
2004: Erik K Alexander; Ellen Marqusee; Jennifer Lawrence; Petr Jarolim; George A Fischer; P Reed Larsen
Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism.
The New England journal of medicine 2004;351(3):241-9.
2004: Suzy Bianco; Brian W. Kim; Julie X Zhang; John W Harney; Rogério S Ribeiro; Balázs Gereben; Antonio Bianco; Ulrike Mende; P Reed Larsen
Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1840-9.
2004: Csaba Fekete; Balázs Gereben; Marton Doleschall; John W Harney; José Miguel Dora; Antonio Bianco; Sumit Sarkar; Zsolt Liposits; William Rand; Charles Emerson; Imre Kacskovics; P Reed Larsen; Ronald M Lechan
Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
Endocrinology 2004;145(4):1649-55.
2004: Brian W. Kim; Suzy Bianco; P Reed Larsen
Thyroid hormone and adrenergic signaling in the heart.
Arquivos brasileiros de endocrinologia e metabologia 2004;48(1):171-5.
2003: Brian W. Kim; Ann Marie Zavacki; Cyntia Curcio-Morelli; Monica Dentice; John W Harney; P Reed Larsen; Antonio Bianco
Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2603-12.
2003: Isabelle Callebaut; Cyntia Curcio-Morelli; Jean-Paul Mornon; Balázs Gereben; Christoph Buettner; Stephen Huang; Bertrand Castro; Tatiana L Fonseca; John W Harney; P Reed Larsen; Antonio Bianco
The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
The Journal of biological chemistry 2003;278(38):36887-96.
2003: Christopher A French; Erik K Alexander; Edmund S Cibas; Vania Nose; Julia Laguette; William C Faquin; Jeff Garber; Francis Moore; Jonathan A Fletcher; P Reed Larsen; Todd G Kroll
Genetic and biological subgroups of low-stage follicular thyroid cancer.
The American journal of pathology 2003;162(4):1053-60.
2003: Stephen A Huang; David M Dorfman; David R Genest; Domenico Salvatore; P Reed Larsen
Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.
The Journal of clinical endocrinology and metabolism 2003;88(3):1384-8.
2003: Cyntia Curcio-Morelli; Balázs Gereben; Ann Marie Zavacki; Brian W. Kim; Stephen Huang; John W Harney; P Reed Larsen; Antonio Bianco
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.
Endocrinology 2003;144(3):937-46.
2003: Erik K Alexander; Shelley Hurwitz; Jenny P Heering; Carol B Benson; Mary C Frates; Peter M Doubilet; Edmund S Cibas; P Reed Larsen; Ellen Marqusee
Natural history of benign solid and cystic thyroid nodules.
Annals of internal medicine 2003;138(4):315-8.
2003: Brian W. Kim; G H Daniels; B J Harrison; A Price; John W Harney; P Reed Larsen; A P Weetman
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels.
The Journal of clinical endocrinology and metabolism 2003;88(2):594-8.
2003: Munira Baqui; Diego Botero; Balázs Gereben; Cyntia Curcio; John W Harney; Domenico Salvatore; Kenji Sorimachi; P Reed Larsen; Antonio Bianco
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
The Journal of biological chemistry 2003;278(2):1206-11.
2002: Stephen A Huang; Stephanie A Fish; David M Dorfman; Domenico Salvatore; Harry P W Kozakewich; Susan J Mandel; P Reed Larsen
A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase.
The Journal of clinical endocrinology and metabolism 2002;87(10):4457-61.
2002: Balázs Gereben; Anna Kollár; John W Harney; P Reed Larsen
The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1667-79.
2002: Erik K Alexander; P Reed Larsen
High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease.
The Journal of clinical endocrinology and metabolism 2002;87(3):1073-7.
2002: Antonio Bianco; Domenico Salvatore; Balázs Gereben; Marla J Berry; P Reed Larsen
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
Endocrine reviews 2002;23(1):38-89.
2001: Lucia A De Jesus; Suzy Bianco; Miriam O Ribeiro; M Schneider; S W Kim; John W Harney; P Reed Larsen; Antonio Bianco
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
The Journal of clinical investigation 2001;108(9):1379-85.
2001: Serge Van Der Geyten; Ilse B Segers; Balázs Gereben; T Bartha; Péter Rudas; P Reed Larsen; Eduard R Kühn; Veerle M Darras
Transcriptional regulation of iodothyronine deiodinases during embryonic development.
Molecular and cellular endocrinology 2001;183(1-2):1-9.
2001: C Curcio; Munira Baqui; Domenico Salvatore; bertrand rihn; Steve Mohr; John W Harney; P Reed Larsen; Antonio Bianco
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
The Journal of biological chemistry 2001;276(32):30183-7.
2001: R Peeters; C Fekete; Carla Goncalves; Gabor Legradi; HM Tu; John W Harney; Antonio Bianco; Ronald M Lechan; P Reed Larsen
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
American journal of physiology. Endocrinology and metabolism 2001;281(1):E54-61.
2001: Balázs Gereben; Domenico Salvatore; John W Harney; HM Tu; P Reed Larsen
The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1).
Molecular endocrinology (Baltimore, Md.) 2001;15(1):112-24.
2001: J Pachucki; J Hopkins; R Peeters; H Tu; Suzy Bianco; Helen C Kaulbach; E Dale Abel; Fredric E Wondisford; Joanne S Ingwall; P Reed Larsen
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
Endocrinology 2001;142(1):13-20.
2000: Christoph Buettner; John W Harney; P Reed Larsen
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase.
Endocrinology 2000;141(12):4606-12.
2000: Ellen Marqusee; Carol B Benson; Mary C Frates; Peter M Doubilet; P Reed Larsen; Edmund S Cibas; Susan J Mandel
Usefulness of ultrasonography in the management of nodular thyroid disease.
Annals of internal medicine 2000;133(9):696-700.
2000: Munira Baqui; Balázs Gereben; John W Harney; P Reed Larsen; Antonio Bianco
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.
Endocrinology 2000;141(11):4309-12.
2000: Balázs Gereben; Carla Goncalves; John W Harney; P Reed Larsen; Antonio Bianco
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1697-708.
2000: Stephen A Huang; HM Tu; John W Harney; Maria Venihaki; Atul Butte; Harry P W Kozakewich; Steven J Fishman; P Reed Larsen
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.
The New England journal of medicine 2000;343(3):185-9.
2000: Csaba Fekete; Emese Mihály; S Herscovici; J Salas; H Tu; P Reed Larsen; Ronald M Lechan
DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity.
Brain research 2000;862(1-2):154-61.
2000: J Steinsapir; Antonio Bianco; Christoph Buettner; John W Harney; P Reed Larsen
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Endocrinology 2000;141(3):1127-35.
2000: T Bartha; S W Kim; Domenico Salvatore; Balázs Gereben; HM Tu; John W Harney; Péter Rudas; P Reed Larsen
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene.
Endocrinology 2000;141(1):229-37.
1999: J Pachucki; Lynn A Burmeister; P Reed Larsen
Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart.
Circulation research 1999;85(6):498-503.
1999: Balázs Gereben; T Bartha; HM Tu; John W Harney; Péter Rudas; P Reed Larsen
Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase.
The Journal of biological chemistry 1999;274(20):13768-76.
1999: Domenico Salvatore; John W Harney; P Reed Larsen
Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties.
Biochimie 1999;81(5):535-8.
1999: HM Tu; Gabor Legradi; T Bartha; Domenico Salvatore; Ronald M Lechan; P Reed Larsen
Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone.
Endocrinology 1999;140(2):784-90.
1998: Christoph Buettner; John W Harney; P Reed Larsen
The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element.
The Journal of biological chemistry 1998;273(50):33374-8.
1998: J Steinsapir; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes.
The Journal of clinical investigation 1998;102(11):1895-9.
1998: S W Kim; John W Harney; P Reed Larsen
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction.
Endocrinology 1998;139(12):4895-905.
1998: Domenico Salvatore; T Bartha; P Reed Larsen
The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure.
The Journal of biological chemistry 1998;273(47):31092-6.
1998: Chen-Yu zhang; S Kim; John W Harney; P Reed Larsen
Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene.
Endocrinology 1998;139(3):1156-63.
1997: B C Sun; John W Harney; Marla J Berry; P Reed Larsen
The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase.
Endocrinology 1997;138(12):5452-8.
1997: HM Tu; S W Kim; Domenico Salvatore; T Bartha; Gabor Legradi; P Reed Larsen; Ronald M Lechan
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone.
Endocrinology 1997;138(8):3359-68.
1997: P Reed Larsen
Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone.
Biochemical Society transactions 1997;25(2):588-92.
1997: P Reed Larsen
Van Meter Prize of the American Thyroid Association to Gregory Brent.
Thyroid : official journal of the American Thyroid Association 1997;7(1):153-4.
1997: N Toyoda; E Kaptein; Marla J Berry; John W Harney; P Reed Larsen; T J Visser
Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases.
Endocrinology 1997;138(1):213-9.
1996: Warner S Simonides; G A Brent; M H Thelen; C G van der Linden; P Reed Larsen; Cornelis Van Hardeveld
Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness.
The Journal of biological chemistry 1996;271(50):32048-56.
1996: Domenico Salvatore; HM Tu; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase is highly expressed in human thyroid.
The Journal of clinical investigation 1996;98(4):962-8.
1996: Ana Luiza Maia; John W Harney; P Reed Larsen
Is there a negative TRE in the luciferase reporter cDNA?
Thyroid : official journal of the American Thyroid Association 1996;6(4):325-8.
1996: S W Kim; I M Ahn; P Reed Larsen
In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines.
Molecular and cellular biology 1996;16(8):4465-77.
1996: Domenico Salvatore; T Bartha; John W Harney; P Reed Larsen
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase.
Endocrinology 1996;137(8):3308-15.
1996: A M Zavacki; John W Harney; G A Brent; P Reed Larsen
Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor.
Endocrinology 1996;137(7):2833-41.
1996: N Toyoda; N Kleinhaus; P Reed Larsen
The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency.
The Journal of clinical endocrinology and metabolism 1996;81(6):2121-4.
1996: A M Zavacki; Chen-Yu zhang; John W Harney; P Reed Larsen
Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element.
Endocrinology 1996;137(4):1438-46.
1995: Domenico Salvatore; S C Low; M Berry; Ana Luiza Maia; John W Harney; W Croteau; Donald L St Germain; P Reed Larsen
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.
The Journal of clinical investigation 1995;96(5):2421-30.
1995: Ana Luiza Maia; JD Kieffer; John W Harney; P Reed Larsen
Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice.
Endocrinology 1995;136(11):4842-9.
1995: N Toyoda; A M Zavacki; Ana Luiza Maia; John W Harney; P Reed Larsen
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene.
Molecular and cellular biology 1995;15(9):5100-12.
1995: Ana Luiza Maia; Marla J Berry; R Sabbag; John W Harney; P Reed Larsen
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
Molecular endocrinology (Baltimore, Md.) 1995;9(8):969-80.
1995: N Toyoda; Marla J Berry; John W Harney; P Reed Larsen
Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1).
The Journal of biological chemistry 1995;270(20):12310-8.
1995: S J Mandel; G A Brent; Michael E Weinblatt; P Reed Larsen
Prospective studies of thyroid function in patients receiving gold therapy.
Thyroid : official journal of the American Thyroid Association 1995;5(2):113-6.
1995: Ana Luiza Maia; John W Harney; P Reed Larsen
Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways.
Endocrinology 1995;136(4):1488-94.
1995: P Reed Larsen
The American Thyroid Association: d'où venons nous? Que sommes nous? Où allons nous? (Whence do we come? What are we? Where are we going?).
Thyroid : official journal of the American Thyroid Association 1995;5(1):1-5.
1995: P Reed Larsen; Marla J Berry
Nutritional and hormonal regulation of thyroid hormone deiodinases.
Annual review of nutrition 1995;15():323-52.
1994: N Toyoda; John W Harney; Marla J Berry; P Reed Larsen
Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes.
The Journal of biological chemistry 1994;269(32):20329-34.
1994: P Reed Larsen; Marla J Berry
Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction.
Thyroid : official journal of the American Thyroid Association 1994;4(3):357-62.
1994: S J Mandel; G A Brent; P Reed Larsen
Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis.
Thyroid : official journal of the American Thyroid Association 1994;4(1):129-33.
1993: Marla J Berry; P Reed Larsen
Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress.
Biochemical Society transactions 1993;21(4):827-32.
1993: A M Zavacki; John W Harney; G A Brent; P Reed Larsen
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1319-30.
1993: S J Mandel; G A Brent; P Reed Larsen
Levothyroxine therapy in patients with thyroid disease.
Annals of internal medicine 1993;119(6):492-502.
1993: Marla J Berry; D Grieco; B A Taylor; Ana Luiza Maia; JD Kieffer; W Beamer; E Glover; A Poland; P Reed Larsen
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
The Journal of clinical investigation 1993;92(3):1517-28.
1993: Marla J Berry; L Banu; John W Harney; P Reed Larsen
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons.
The EMBO journal 1993;12(8):3315-22.
1993: W S Lee; Marla J Berry; Matthias A Hediger; P Reed Larsen
The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule.
Endocrinology 1993;132(5):2136-40.
1993: Marla J Berry; P Reed Larsen
Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase.
The American journal of clinical nutrition 1993;57(2 Suppl):249S-255S.
1992: S J Mandel; Marla J Berry; JD Kieffer; John W Harney; R L Warne; P Reed Larsen
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase.
The Journal of clinical endocrinology and metabolism 1992;75(4):1133-9.
1992: Marla J Berry; Ana Luiza Maia; JD Kieffer; John W Harney; P Reed Larsen
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.
Endocrinology 1992;131(4):1848-52.
1992: G R Williams; John W Harney; David D Moore; P Reed Larsen; G A Brent
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1527-37.
1992: Marla J Berry; P Reed Larsen
The role of selenium in thyroid hormone action.
Endocrine reviews 1992;13(2):207-19.
1992: G A Brent; G R Williams; John W Harney; B M Forman; Herbert H Samuels; David D Moore; P Reed Larsen
Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.
Molecular endocrinology (Baltimore, Md.) 1992;6(4):502-14.
1992: P Reed Larsen
Monitoring thyroxine treatment during pregnancy.
Thyroid : official journal of the American Thyroid Association 1992;2(2):153-4.
1991: M Noronha; A Raasmaja; N Moolten; P Reed Larsen
Triiodothyronine causes rapid reversal of alpha 1/cyclic adenosine monophosphate synergism on brown adipocyte respiration and type II deiodinase activity.
Metabolism: clinical and experimental 1991;40(12):1327-32.
1991: Marla J Berry; L Banu; Y Y Chen; S J Mandel; JD Kieffer; John W Harney; P Reed Larsen
Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region.
Nature 1991;353(6341):273-6.
1991: Marla J Berry; JD Kieffer; John W Harney; P Reed Larsen
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase.
The Journal of biological chemistry 1991;266(22):14155-8.
1991: JD Kieffer; P Reed Larsen
Photoaffinity labeling of rat type I iodothyronine deiodinase.
Endocrinology 1991;129(2):1042-8.
1991: Marla J Berry; JD Kieffer; P Reed Larsen
Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase.
Endocrinology 1991;129(1):550-2.
1991: P Reed Larsen; R Warne
Antiestrogens stimulate expression of transiently transfected and endogenous genes in rat pituitary tumor cell lines.
Molecular and cellular endocrinology 1991;77(1-3):133-40.
1991: G A Brent; G R Williams; John W Harney; B M Forman; Herbert H Samuels; David D Moore; P Reed Larsen
Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine.
Molecular endocrinology (Baltimore, Md.) 1991;5(4):542-8.
1991: Marla J Berry; L Banu; P Reed Larsen
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme.
Nature 1991;349(6308):438-40.
1990: S J Mandel; P Reed Larsen; Ellen W Seely; G A Brent
Increased need for thyroxine during pregnancy in women with primary hypothyroidism.
The New England journal of medicine 1990;323(2):91-6.
1990: Marla J Berry; A L Kates; P Reed Larsen
Thyroid hormone regulates type I deiodinase messenger RNA in rat liver.
Molecular endocrinology (Baltimore, Md.) 1990;4(5):743-8.
1989: G A Brent; John W Harney; Y Chen; R L Warne; David D Moore; P Reed Larsen
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1996-2004.
1989: G A Brent; M K Dunn; John W Harney; T Gulick; P Reed Larsen; David D Moore
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor.
The New biologist 1989;1(3):329-36.
1989: A Raasmaja; P Reed Larsen
Alpha 1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes.
Endocrinology 1989;125(5):2502-9.
1989: Richard A Hodin; Mitchell Lazar; B I Wintman; Douglas Darling; Ronald J Koenig; P Reed Larsen; David D Moore; William W Chin
Identification of a thyroid hormone receptor that is pituitary-specific.
Science (New York, N.Y.) 1989;244(4900):76-9.
1989: Ronald J Koenig; Mitchell Lazar; Richard A Hodin; G A Brent; P Reed Larsen; William W Chin; David D Moore
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing.
Nature 1989;337(6208):659-61.
1989: G A Brent; P Reed Larsen; John W Harney; Ronald J Koenig; David D Moore
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor.
The Journal of biological chemistry 1989;264(1):178-82.
1989: I Mills; A Raasmaja; N Moolten; G Lemack; J Enrique Silva; P Reed Larsen
Effect of thyroid status on catecholamine stimulation of thyroxine 5'-deiodinase in brown adipocytes.
The American journal of physiology 1989;256(1 Pt 1):E74-9.
1988: G A Brent; John W Harney; David D Moore; P Reed Larsen
Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 1988;2(9):792-8.
1988: Ronald J Koenig; R L Warne; G A Brent; John W Harney; P Reed Larsen; David D Moore
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5031-5.
1988: R M Barge; I Mills; J Enrique Silva; P Reed Larsen
Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes.
The American journal of physiology 1988;254(3 Pt 1):E323-7.
1988: P Reed Larsen
Thyroid hormone metabolism in the central nervous system.
Acta medica Austriaca 1988;15 Suppl 1():5-10.
1987: Ronald J Koenig; G A Brent; R L Warne; P Reed Larsen; David D Moore
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5670-4.