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Nils-Göran Larsson

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Chemicals & Drugs

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DNA Mutational Analysis

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Marie Lagouge; Nils-Göran Larsson
The role of mitochondrial DNA mutations and free radicals in disease and ageing.
Dusanka Milenkovic; Chan Bae Park; Benedetta Ruzzenente; Stanka Matic; Maria Falkenberg; Christoph Freyer; Elisabeth Jemt; Inge Kühl; Nils-Göran Larsson
TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication.
Mügen Terzioglu; Rolf Wibom; Maria Falkenberg; Claes M Gustafsson; Bianca Habermann; Julia Harmel; Elisabeth Jemt; Christian Kukat; Marcela Dávila López; Caroline Meharg; Arnaud Mourier; Chan Bae Park; Benedetta Ruzzenente; James B Stewart; Nils-Göran Larsson
MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.

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All Publications

2013: Marie Lagouge; Nils-Göran Larsson
The role of mitochondrial DNA mutations and free radicals in disease and ageing.
Journal of internal medicine 2013;273(6):529-43.
2013: Dusanka Milenkovic; Chan Bae Park; Benedetta Ruzzenente; Stanka Matic; Maria Falkenberg; Christoph Freyer; Elisabeth Jemt; Inge Kühl; Nils-Göran Larsson
TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication.
Human molecular genetics 2013;22(10):1983-93.
2013: Mügen Terzioglu; Rolf Wibom; Maria Falkenberg; Claes M Gustafsson; Bianca Habermann; Julia Harmel; Elisabeth Jemt; Christian Kukat; Marcela Dávila López; Caroline Meharg; Arnaud Mourier; Chan Bae Park; Benedetta Ruzzenente; James B Stewart; Nils-Göran Larsson
MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.
Cell metabolism 2013;17(4):618-26.
2013: Ana Bratic; Nils-Göran Larsson
The role of mitochondria in aging.
The Journal of clinical investigation 2013;123(3):951-7.
2013: Anna Wredenberg; Francesca Baggio; Ana Bratic; Christoph Freyer; Sebastian Grönke; Bianca Habermann; Elisabeth Kremmer; Christian Kukat; Marie Lagouge; Metodi D Metodiev; Arnaud Mourier; Chan Bae Park; Linda Partridge; Paola Loguercio Polosa; Benedetta Ruzzenente; Henrik Spåhr; Luke Tain; Rolf Wibom; Nils-Göran Larsson
MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.
PLoS genetics 2013;9(1):e1003178.
2012: Cecile VERNOCHET; Cristina M Zingaretti; Nils-Göran Larsson; Kevin Y Lee; Yazmín Macotela; Arnaud Mourier; Christopher B Newgard; Matthew J Rardin; Graham Smyth; Ding An; Olivier Bezy; Jeremie Boucher; Saverio Cinti; Brice Emanuelli; Bradford W Gibson; Olga R Ilkayeva; C Ronald Kahn
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
Cell metabolism 2012;16(6):765-76.
2012: Sjoerd Wanrooij; Claes M Gustafsson; Nils-Göran Larsson; Javier Miralles Fusté; Tore Samuelsson; James B Stewart; Paulina Wanrooij; Maria Falkenberg
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
EMBO reports 2012;13(12):1130-7.
2012: Seungmin Lee; Arnaud Mourier; Lars Olson; Fredrik H Sterky; Mügen Terzioglu; Staffan Cullheim; Nils-Göran Larsson
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.
Human molecular genetics 2012;21(22):4827-35.
2012: Christoph Freyer; Erik Hagström; Camilla Koolmeister; Nils-Göran Larsson; Dusanka Milenkovic; Arnaud Mourier; David Samuels; James Bruce Stewart; Timothy Wai; Rudolf J Wiesner; Emmanouella E Chatzidaki; Lynsey M Cree; Vasileios I Floros; Patrick F Chinnery
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Nature genetics 2012;44(11):1282-5.
2012: Eva R Almajan; Esther Barth; Thorsten Decker; Peter Kloppenburg; Thomas Langer; Nils-Göran Larsson; Paola Martinelli; Lars Paeger; Ricarda Richter; Elena I Rugarli
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival.
The Journal of clinical investigation 2012;122(11):4048-58.
2012: Yonghong Shi; Paulina Wanrooij; Sjoerd Wanrooij; L Marcus Wilhelmsson; Anke Dierckx; Marten Falkenberg; Nils-Göran Larsson; Claes M Gustafsson
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16510-5.
2012: Henrik Spåhr; Nils-Göran Larsson; Claes M Gustafsson; Bianca Habermann; B Martin Hallberg
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15253-8.
2012: Fredrik H Sterky; Rolf Wibom; Betty Bao; Daniel Edgar; Alexander F Hoffman; Carl R Lupica; Dusanka Milenkovic; Lars Olson; Arianna Paganelli; Nils-Göran Larsson
Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons.
Human molecular genetics 2012;21(5):1078-89.
2012: Benedetta Ruzzenente; James B Stewart; Paul Tempst; Rolf Wibom; Anna Wredenberg; Volker Zickermann; Ulrich Brandt; Ana Bratic; Yolanda Cámara; Hediye Erdjument-Bromage; Claes M Gustafsson; Kjell Hultenby; Metodi D Metodiev; Dusanka Milenkovic; Chan Bae Park; Nils-Göran Larsson
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.
The EMBO journal 2012;31(2):443-56.
2012: Karin Naess; Antal Nemeth; Inger Nennesmo; Ulrika von Döbeln; Rolf Wibom; Michela Barbaro; Helene Bruhn; Nils-Göran Larsson; Nicole Lesko
Complete Deletion of a POLG1 Allele in a Patient with Alpers Syndrome.
JIMD reports 2012;4():67-73.
2011: B Martin Hallberg; Nils-Göran Larsson
TFAM forces mtDNA to make a U-turn.
Nature structural & molecular biology 2011;18(11):1179-81.
2011: Daniel C Andersson; Jérémy Fauconnier; Niklas Ivarsson; Nils-Göran Larsson; Chan Bae Park; Jérôme Thireau; Shi-Jin Zhang; Håkan Westerblad
Enhanced cardiomyocyte Ca(2+) cycling precedes terminal AV-block in mitochondrial cardiomyopathy Mterf3 KO mice.
Antioxidants & redox signaling 2011;15(9):2455-64.
2011: Ana Bratic; Sebastian Grönke; Bianca Habermann; Christian Kukat; Arnaud Mourier; Linda Partridge; Benedetta Ruzzenente; James Bruce Stewart; Rolf Wibom; Anna Wredenberg; Nils-Göran Larsson
The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.
PLoS genetics 2011;7(10):e1002324.
2011: Olivier R Baris; Jennifer E Kloepper; Anke Klose; Thomas Krieg; Thomas Langer; Nils-Göran Larsson; Carsten Merkwirth; Alexander Müller; Johannes F G Neuhaus; Ralf Paus; Matthias Schauen; Desmond J Tobin; Daniela Weiland; Anna Wille; Rudolf J Wiesner
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.
Stem cells (Dayton, Ohio) 2011;29(9):1459-68.
2011: Christian Kukat; Nils-Göran Larsson; Henrik Spåhr; Christian A Wurm; Maria Falkenberg; Stefan Jakobs
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13534-9.
2011: Fredrik H Sterky; Rolf Wibom; Seungmin Lee; Lars Olson; Nils-Göran Larsson
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):12937-42.
2011: Arnaud Mourier; Nils-Göran Larsson
Tracing the trail of protons through complex I of the mitochondrial respiratory chain.
PLoS biology 2011;9(8):e1001129.
2011: Chan Bae Park; Nils-Göran Larsson
Mitochondrial DNA mutations in disease and aging.
The Journal of cell biology 2011;193(5):809-18.
2011: Yolanda Cámara; Jorge Asin-Cayuela; Chan Bae Park; Metodi D Metodiev; Yonghong Shi; Benedetta Ruzzenente; Christian Kukat; Bianca Habermann; Rolf Wibom; Kjell Hultenby; Thomas Franz; Hediye Erdjument-Bromage; Paul Tempst; B Martin Hallberg; Claes M Gustafsson; Nils-Göran Larsson
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
Cell metabolism 2011;13(5):527-39.
2011: Michael P Murphy; Arne Holmgren; Nils-Göran Larsson; Barry Halliwell; Christopher J Chang; Balaraman Kalyanaraman; Sue Goo Rhee; Paul J Thornalley; Linda Partridge; David Gems; Thomas Nyström; Vsevolod Belousov; Paul T Schumacker; Christine C Winterbourn
Unraveling the biological roles of reactive oxygen species.
Cell metabolism 2011;13(4):361-6.
2011: Cameron H Good; Alexander F Hoffman; Barry J Hoffer; Vladimir I Chefer; Toni S Shippenberg; Cristina M Bäckman; Nils-Göran Larsson; Lars Olson; Sandra Gellhaar; Dagmar Galter; Carl R Lupica
Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1333-44.
2011: Neli Atanassova; Javier Miralles Fusté; Sjoerd Wanrooij; Bertil Macao; Steffi Goffart; Stefan Bäckström; Géraldine Farge; Ivan Khvorostov; Nils-Göran Larsson; Johannes N Spelbrink; Maria Falkenberg
Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia.
Human molecular genetics 2011;20(6):1212-23.
2011: Adam Ameur; James B Stewart; Christoph Freyer; Erik Hagström; Max Ingman; Nils-Göran Larsson; Ulf Gyllensten
Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.
PLoS genetics 2011;7(3):e1002028.
2011: Thomas Koeck; Anders H Olsson; Marloes Dekker Nitert; Vladimir V Sharoyko; Claes Ladenvall; Olga Kotova; Erwin Reiling; Tina Rönn; Hemang Parikh; Jalal Taneera; Johan G Eriksson; Metodi D Metodiev; Nils-Göran Larsson; Alexander Balhuizen; Holger Luthman; Alena Stančáková; Johanna Kuusisto; Markku Laakso; Pernille Poulsen; Allan Vaag; Leif Groop; Valeriya Lyssenko; Hindrik Mulder; Charlotte Ling
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Cell metabolism 2011;13(1):80-91.
2010: Jaime M Ross; Johanna Öberg; Stefan Brené; Giuseppe Coppotelli; Mügen Terzioglu; Karin Pernold; Michel Goiny; Rouslan Sitnikov; Julia Kehr; Aleksandra Trifunovic; Nils-Göran Larsson; Barry J Hoffer; Lars Olson
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20087-92.
2010: Christoph Freyer; Chan Bae Park; Mats I Ekstrand; Yonghong Shi; Julia Khvorostova; Rolf Wibom; Marten Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription.
Nucleic acids research 2010;38(19):6577-88.
2010: Fredrik H Sterky; Benedetta Ruzzenente; Claes M Gustafsson; Tore Samuelsson; Nils-Göran Larsson
LRPPRC is a mitochondrial matrix protein that is conserved in metazoans.
Biochemical and biophysical research communications 2010;398(4):759-64.
2010: Claes M Gustafsson; Nils-Göran Larsson
MTERF1 gives mtDNA an unusual twist.
Cell metabolism 2010;12(1):3-4.
2010: Nicole Lesko; Karin Naess; Rolf Wibom; Nicola Solaroli; Inger Nennesmo; Ulrika von Döbeln; Anna Karlsson; Nils-Göran Larsson
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion.
Neuromuscular disorders : NMD 2010;20(3):198-203.
2010: Nils-Göran Larsson
Somatic mitochondrial DNA mutations in mammalian aging.
Annual review of biochemistry 2010;79():683-706.
2010: Daniel Edgar; Nils-Göran Larsson; Aleksandra Trifunovic
Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse.
Cell metabolism 2010;11(1):1.
2009: Banafsheh Kadkhodaei; Takehito Ito; Eliza Joodmardi; Bengt Mattsson; Claude Rouillard; Manolo Carta; Shin-ichi Muramatsu; Chiho Sumi-Ichinose; Takahide Nomura; Daniel Metzger; Pierre Chambon; Eva Lindqvist; Nils-Göran Larsson; Lars Olson; Anders Björklund; Hiroshi Ichinose; Thomas Perlmann
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(50):15923-32.
2009: Maria Falkenberg; Nils-Göran Larsson
Structure casts light on mtDNA replication.
Cell 2009;139(2):231-3.
2009: Daniel Edgar; Irina Shabalina; Yolanda Camara; Anna Wredenberg; Maria Antonietta Calvaruso; Leo Nijtmans; Jan Nedergaard; Barbara Cannon; Nils-Göran Larsson; Aleksandra Trifunovic
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Cell metabolism 2009;10(2):131-8.
2009: Izabella Baranowska; Karin Hultin Jäderlund; Inger Nennesmo; Erik Holmqvist; Nadja Heidrich; Nils-Göran Larsson; Göran Andersson; E Gerhart H Wagner; Ake Hedhammar; Rolf Wibom; Leif Andersson
Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene.
PLoS genetics 2009;5(5):e1000499.
2009: Karin Naess; Christoph Freyer; Helene Bruhn; Rolf Wibom; Gunilla Malm; Inger Nennesmo; Ulrika von Döbeln; Nils-Göran Larsson
MtDNA mutations are a common cause of severe disease phenotypes in children with Leigh syndrome.
Biochimica et biophysica acta 2009;1787(5):484-90.
2009: Metodi D Metodiev; Nicole Lesko; Chan Bae Park; Yolanda Cámara; Yonghong Shi; Rolf Wibom; Kjell Hultenby; Claes M Gustafsson; Nils-Göran Larsson
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.
Cell metabolism 2009;9(4):386-97.
2009: Nils-Göran Larsson
Introduction: Euromit VII--summarizing 50 years of research on mitochondrial disease.
Journal of internal medicine 2009;265(2):170-3.
2008: James Bruce Stewart; Christoph Freyer; Joanna Elson; Nils-Göran Larsson
Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease.
Nature reviews. Genetics 2008;9(9):657-62.
2008: Eric Dufour; Mügen Terzioglu; Fredrik Hansson Sterky; Lene Sörensen; Dagmar Galter; Lars Olson; Johannes Wilbertz; Nils-Göran Larsson
Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration.
Human molecular genetics 2008;17(10):1418-26.
2008: Fredrik Hansson Sterky; Nils-Göran Larsson
Complex I: a complex gateway to the powerhouse.
Cell metabolism 2008;7(4):278-9.
2008: Aleksandra Trifunovic; Nils-Göran Larsson
Mitochondrial dysfunction as a cause of ageing.
Journal of internal medicine 2008;263(2):167-78.
2008: James Bruce Stewart; Christoph Freyer; Joanna Elson; Anna Wredenberg; Zekiye Cansu; Aleksandra Trifunovic; Nils-Göran Larsson
Strong purifying selection in transmission of mammalian mitochondrial DNA.
PLoS biology 2008;6(1):e10.
2008: Joseph D Bruton; Nicolas Place; Takashi Yamada; Jose P Silva; Francisco H Andrade; Anders J Dahlstedt; Shi-Jin Zhang; Abram Katz; Nils-Göran Larsson; Håkan Westerblad
Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice.
The Journal of physiology 2008;586(1):175-84.
2007: Christoph Freyer; Nils-Göran Larsson
Is energy deficiency good in moderation?
Cell 2007;131(3):448-50.
2007: Xianzhi Niu; Aleksandra Trifunovic; Nils-Göran Larsson; Barbara Canlon
Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Experimental cell research 2007;313(18):3924-34.
2007: Chan Bae Park; Jorge Asin-Cayuela; Yolanda Cámara; Yonghong Shi; Mina Pellegrini; Martina Gaspari; Rolf Wibom; Kjell Hultenby; Hediye Erdjument-Bromage; Paul Tempst; Maria Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Cell 2007;130(2):273-85.
2007: Mats I Ekstrand; Mügen Terzioglu; Dagmar Galter; Shunwei Zhu; Christoph Hofstetter; Eva Lindqvist; Sebastian Thams; Anita Bergstrand; Fredrik Sterky Hansson; Aleksandra Trifunovic; Barry Hoffer; Staffan Cullheim; Abdul H Mohammed; Lars Olson; Nils-Göran Larsson
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1325-30.
2007: Mügen Terzioglu; Nils-Göran Larsson
Mitochondrial dysfunction in mammalian ageing.
Novartis Foundation symposium 2007;287():197-208; discussion 208-13.
2007: Maria Falkenberg; Nils-Göran Larsson; Claes M Gustafsson
DNA replication and transcription in mammalian mitochondria.
Annual review of biochemistry 2007;76():679-99.
2006: Stéphane Duvezin-Caubet; Ravi Jagasia; Johannes Wagener; Sabine Hofmann-Thiel; Aleksandra Trifunovic; Anna Hansson; Anne Chomyn; Matthias F Bauer; Giuseppe Attardi; Nils-Göran Larsson; Walter Neupert; Andreas S Reichert
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
The Journal of biological chemistry 2006;281(49):37972-9.
2006: Anna Wredenberg; Christoph Freyer; Marie E Sandström; Abram Katz; Rolf Wibom; Håkan Westerblad; Nils-Göran Larsson
Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance.
Biochemical and biophysical research communications 2006;350(1):202-7.
2005: Aleksandra Trifunovic; Anna Hansson; Anna Wredenberg; Anja T Rovio; Eric Dufour; Ivan Khvorostov; Johannes N Spelbrink; Rolf Wibom; Howard T Jacobs; Nils-Göran Larsson
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):17993-8.
2005: Jose P Silva; Irina Shabalina; Eric Dufour; Natasa Petrovic; Emma C Backlund; Kjell Hultenby; Rolf Wibom; Jan Nedergaard; Barbara Cannon; Nils-Göran Larsson
SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity.
The EMBO journal 2005;24(23):4061-70.
2005: Tomas Linder; Chan Bae Park; Jordi Asin-Cayuela; Mina Pellegrini; Nils-Göran Larsson; Maria Falkenberg; Tore Samuelsson; Claes M Gustafsson
A family of putative transcription termination factors shared amongst metazoans and plants.
Current genetics 2005;48(4):265-9.
2005: Nayla Esteitie; Reetta Hinttala; Rolf Wibom; Helene Nilsson; Nicole Hance; Karin Naess; Kristina Teär-Fahnehjelm; Ulrika von Döbeln; Kari Majamaa; Nils-Göran Larsson
Secondary metabolic effects in complex I deficiency.
Annals of neurology 2005;58(4):544-52.
2005: Pasi Tavi; Anna Hansson; Shi-Jin Zhang; Nils-Göran Larsson; Håkan Westerblad
Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy.
Human molecular genetics 2005;14(8):1069-76.
2004: Martina Gaspari; Nils-Göran Larsson; Claes M Gustafsson
The transcription machinery in mammalian mitochondria.
Biochimica et biophysica acta 2004;1659(2-3):148-52.
2004: Martina Gaspari; Maria Falkenberg; Nils-Göran Larsson; Claes M Gustafsson
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.
The EMBO journal 2004;23(23):4606-14.
2004: Eric Dufour; Nils-Göran Larsson
Understanding aging: revealing order out of chaos.
Biochimica et biophysica acta 2004;1658(1-2):122-32.
2004: Aleksandra Trifunovic; Anna Wredenberg; Maria Falkenberg; Johannes N Spelbrink; Anja T Rovio; Carl Bruder; Mohammad Bohlooly-Y; Sebastian Gidlöf; Anders Oldfors; Rolf Wibom; Jan Törnell; Howard T Jacobs; Nils-Göran Larsson
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Nature 2004;429(6990):417-23.
2004: Mats I Ekstrand; Maria Falkenberg; Anja Rantanen; Chan Bae Park; Martina Gaspari; Kjell Hultenby; Pierre Rustin; Claes M Gustafsson; Nils-Göran Larsson
Mitochondrial transcription factor A regulates mtDNA copy number in mammals.
Human molecular genetics 2004;13(9):935-44.
2004: Anna Hansson; Nicole Hance; Eric Dufour; Anja Rantanen; Kjell Hultenby; David A Clayton; Rolf Wibom; Nils-Göran Larsson
A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3136-41.
2003: Anja Rantanen; Martina Gaspari; Maria Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(1):1-6.
2002: Anna Wredenberg; Rolf Wibom; Hans Wilhelmsson; Caroline Graff; Heidi H Wiener; Steven J Burden; Anders Oldfors; Håkan Westerblad; Nils-Göran Larsson
Increased mitochondrial mass in mitochondrial myopathy mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15066-71.
2002: Nils-Göran Larsson
Leber hereditary optic neuropathy: a nuclear solution of a mitochondrial problem.
Annals of neurology 2002;52(5):529-30.
2002: Caroline Graff; The-Hung Bui; Nils-Göran Larsson
Mitochondrial diseases.
Best practice & research. Clinical obstetrics & gynaecology 2002;16(5):715-28.
2002: Jose P Silva; Nils-Göran Larsson
Manipulation of mitochondrial DNA gene expression in the mouse.
Biochimica et biophysica acta 2002;1555(1-3):106-10.
2002: Maria Falkenberg; Martina Gaspari; Anja Rantanen; Aleksandra Trifunovic; Nils-Göran Larsson; Claes M Gustafsson
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Nature genetics 2002;31(3):289-94.
2002: Aleksandra Trifunovic; Nils-Göran Larsson
Tissue-specific knockout model for study of mitochondrial DNA mutation disorders.
Methods in enzymology 2002;353():409-21.
2002: Mats I Ekstrand; Nils-Göran Larsson
Breeding and genotyping of Tfam conditional knockout mice.
Methods in molecular biology (Clifton, N.J.) 2002;197():391-400.
2001: Nils-Göran Larsson; P Rustin
Animal models for respiratory chain disease.
Trends in molecular medicine 2001;7(12):578-81.
2001: L Sörensen; Mats I Ekstrand; Jose P Silva; Eva Lindqvist; B Xu; P Rustin; Lars Olson; Nils-Göran Larsson
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(20):8082-90.
2001: Anja Rantanen; M Jansson; Anders Oldfors; Nils-Göran Larsson
Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(10):787-92.
2001: J Wang; Jose P Silva; C M Gustafsson; P Rustin; Nils-Göran Larsson
Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4038-43.
2001: Nils-Göran Larsson; Anders Oldfors
Mitochondrial myopathies.
Acta physiologica Scandinavica 2001;171(3):385-93.
2000: Jose P Silva; M Köhler; Caroline Graff; Anders Oldfors; Mark Magnuson; Per-Olof Berggren; Nils-Göran Larsson
Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
Nature genetics 2000;26(3):336-40.
2000: Anja Rantanen; Nils-Göran Larsson
Regulation of mitochondrial DNA copy number during spermatogenesis.
Human reproduction (Oxford, England) 2000;15 Suppl 2():86-91.
2000: Caroline Graff; Anna Wredenberg; Jose P Silva; The-Hung Bui; K Borg; Nils-Göran Larsson
Complex genetic counselling and prenatal analysis in a woman with external ophthalmoplegia and deleted mtDNA.
Prenatal diagnosis 2000;20(5):426-31.
2000: H Li; J Wang; Hans Wilhelmsson; A Hansson; P Thoren; J Duffy; P Rustin; Nils-Göran Larsson
Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3467-72.
1999: Nils-Göran Larsson; R Luft
Revolution in mitochondrial medicine.
FEBS letters 1999;455(3):199-202.
1999: Caroline Graff; David A Clayton; Nils-Göran Larsson
Mitochondrial medicine--recent advances.
Journal of internal medicine 1999;246(1):11-23.
1999: J Wang; Hans Wilhelmsson; Caroline Graff; H Li; Anders Oldfors; P Rustin; J C Brüning; C R Kahn; David A Clayton; Gregory S Barsh; P Thorén; Nils-Göran Larsson
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.
Nature genetics 1999;21(1):133-7.
1998: Nils-Göran Larsson; J Wang; Hans Wilhelmsson; Anders Oldfors; P Rustin; M Lewandoski; Gregory S Barsh; David A Clayton
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.
Nature genetics 1998;18(3):231-6.
1997: Nils-Göran Larsson; A Oldfors; J D Garman; Gregory S Barsh; David A Clayton
Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans.
Human molecular genetics 1997;6(2):185-91.
1997: Nils-Göran Larsson; Gregory S Barsh; David A Clayton
Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam).
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(2):139-40.
1996: Nils-Göran Larsson; J D Garman; Anders Oldfors; Gregory S Barsh; David A Clayton
A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein.
Nature genetics 1996;13(3):296-302.
1996: Massoud Houshmand; Nils-Göran Larsson; Anders Oldfors; Már Tulinius; Elisabeth Holme
Fatal mitochondrial myopathy, lactic acidosis, and complex I deficiency associated with a heteroplasmic A --> G mutation at position 3251 in the mitochondrial tRNALeu(UUR) gne.
Human genetics 1996;97(3):269-73.
1995: Már Tulinius; Massoud Houshmand; Nils-Göran Larsson; Elisabeth Holme; Anders Oldfors; E Holmberg; Jan Wahlström
De novo mutation in the mitochondrial ATP synthase subunit 6 gene (T8993G) with rapid segregation resulting in Leigh syndrome in the offspring.
Human genetics 1995;96(3):290-4.
1995: Anders Oldfors; Ali-Reza Moslemi; Ing-Marie Fyhr; Elisabeth Holme; Nils-Göran Larsson; Christopher Lindberg
Mitochondrial DNA deletions in muscle fibers in inclusion body myositis.
Journal of neuropathology and experimental neurology 1995;54(4):581-7.
1995: Elisabeth Holme; Már Tulinius; Nils-Göran Larsson; Anders Oldfors
Inheritance and expression of mitochondrial DNA point mutations.
Biochimica et biophysica acta 1995;1271(1):249-52.
1995: Nils-Göran Larsson; E Holme; Már Tulinius; Anders Oldfors
Pathogenetic aspects of the A8344g mutation of mitochondrial DNA associated with MERRF syndrome and multiple symmetric lipomas.
Muscle & nerve. Supplement 1995;(3):S102-6.
1995: Nils-Göran Larsson; David A Clayton
Molecular genetic aspects of human mitochondrial disorders.
Annual review of genetics 1995;29():151-78.
1995: Anders Oldfors; E Holme; Már Tulinius; Nils-Göran Larsson
Tissue distribution and disease manifestations of the tRNA(Lys) A-->G(8344) mitochondrial DNA mutation in a case of myoclonus epilepsy and ragged red fibres.
Acta neuropathologica 1995;90(3):328-33.
1995: Már Tulinius; Anders Oldfors; Elisabeth Holme; Nils-Göran Larsson; Massoud Houshmand; P Fahleson; L Sigström; Bengt Kristiansson
Atypical presentation of multisystem disorders in two girls with mitochondrial DNA deletions.
European journal of pediatrics 1995;154(1):35-42.
1995: Nils-Göran Larsson; Már Tulinius; E Holme; Anders Oldfors
Pathogenetic aspects of the A8344G mutation of mitochondrial DNA associated with MERRF syndrome and multiple symmetric lipomas.
Muscle & nerve. Supplement 1995;3():S102-6.
1994: Nils-Göran Larsson; Anders Oldfors; Elisabeth Holme; D A Clayton
Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion.
Biochemical and biophysical research communications 1994;200(3):1374-81.
1994: Massoud Houshmand; Nils-Göran Larsson; Elisabeth Holme; Anders Oldfors; Már Tulinius; Oluf Andersen
Automatic sequencing of mitochondrial tRNA genes in patients with mitochondrial encephalomyopathy.
Biochimica et biophysica acta 1994;1226(1):49-55.
1993: Anders Oldfors; Nils-Göran Larsson; Christopher Lindberg; Elisabeth Holme
Mitochondrial DNA deletions in inclusion body myositis.
Brain : a journal of neurology 1993;116 ( Pt 2)():325-36.
1993: Elisabeth Holme; Nils-Göran Larsson; Anders Oldfors; Már Tulinius; Pelle Sahlin; Göran Stenman
Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome.
American journal of human genetics 1993;52(3):551-6.
1992: Nils-Göran Larsson; Már Tulinius; Elisabeth Holme; Anders Oldfors; Oluf Andersen; Jan Wahlström; Jan Aasly
Segregation and manifestations of the mtDNA tRNA(Lys) A-->G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome.
American journal of human genetics 1992;51(6):1201-12.
1992: Elisabeth Holme; J Greter; C E Jacobson; Nils-Göran Larsson; S Lindstedt; K O Nilsson; Anders Oldfors; Már Tulinius
Mitochondrial ATP-synthase deficiency in a child with 3-methylglutaconic aciduria.
Pediatric research 1992;32(6):731-5.
1992: Nils-Göran Larsson; Elisabeth Holme
Multiple short direct repeats associated with single mtDNA deletions.
Biochimica et biophysica acta 1992;1139(4):311-4.
1992: Anders Oldfors; Nils-Göran Larsson; E Holme; Már Tulinius; B Kadenbach; M Droste
Mitochondrial DNA deletions and cytochrome c oxidase deficiency in muscle fibres.
Journal of the neurological sciences 1992;110(1-2):169-77.
1992: Nils-Göran Larsson; Hans Geir Eiken; H Boman; Elisabeth Holme; Anders Oldfors; Már Tulinius
Lack of transmission of deleted mtDNA from a woman with Kearns-Sayre syndrome to her child.
American journal of human genetics 1992;50(2):360-3.
1991: Nils-Göran Larsson; Oluf Andersen; Elisabeth Holme; Anders Oldfors; Jan Wahlström
Leber's hereditary optic neuropathy and complex I deficiency in muscle.
Annals of neurology 1991;30(5):701-8.
1991: Már Tulinius; Elisabeth Holme; Bengt Kristiansson; Nils-Göran Larsson; Anders Oldfors
Mitochondrial encephalomyopathies in childhood. II. Clinical manifestations and syndromes.
The Journal of pediatrics 1991;119(2):251-9.
1991: Már Tulinius; Elisabeth Holme; Bengt Kristiansson; Nils-Göran Larsson; Anders Oldfors
Mitochondrial encephalomyopathies in childhood. I. Biochemical and morphologic investigations.
The Journal of pediatrics 1991;119(2):242-50.
1991: E Eriksson; Nils-Göran Larsson; Petre Nitescu; LK Appelgren; L E Linder; ID Curelaru
Penetration forces in cannulation of the dorsal veins of the hand: I. A comparison between polyurethane (Insyte) and polytetrafluoroethylene (Venflon) cannulae. Results of a study in volunteers compared with those from an in vitro study.
Acta anaesthesiologica Scandinavica 1991;35(4):306-14.
1990: Nils-Göran Larsson; Elisabeth Holme; Bengt Kristiansson; Anders Oldfors; Már Tulinius
Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome.
Pediatric research 1990;28(2):131-6.
1990: Petre Nitescu; Nils-Göran Larsson; E Eriksson; I Frid; R Volkmann; Hengo Haljamäe; L E Linder; ID Curelaru
Disturbances of blood-flow velocity in the dorsal veins of the hand after vein cannulation and cannula fixation in the anaesthetised patient.
Acta anaesthesiologica Scandinavica 1990;34(2):120-5.
1990: Anders Oldfors; Ing-Marie Fyhr; Elisabeth Holme; Nils-Göran Larsson; Már Tulinius
Neuropathology in Kearns-Sayre syndrome.
Acta neuropathologica 1990;80(5):541-6.
1989: Nils-Göran Larsson; E Holme; Már Tulinius
[DNA diagnosis of mitochondrial diseases is now possible].
Läkartidningen 1989;86(48):4235-6.
1989: Nils-Göran Larsson; K Stenberg; L E Linder; ID Curelaru
Cannula thrombophlebitis: a study in volunteers comparing polytetrafluoroethylene, polyurethane, and polyamide-ether-elastomer cannulae.
Acta anaesthesiologica Scandinavica 1989;33(3):223-31.